Journal articles on the topic '700/.1/03'
To see the other types of publications on this topic, follow the link: 700/.1/03.
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic '700/.1/03.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Islam, MS, MI Ali, MS Hossain, and SMA Chowdhury. "Determination of optimum row spacing for better seed yield and yield contributing characters of advanced mustard (Brassica napus L.) mutants in Bangladesh." Bangladesh Journal of Nuclear Agriculture 37, no. 1 (November 21, 2023): 41–50. http://dx.doi.org/10.3329/bjnag.v37i1.69922.
Full textAbstract:
A field experiment was conducted at BINA substations, Rangpur and Magura in 2018-19 to evaluate the different row spacing on the yield and yield contributing characteristics of advance mustard lines RM-03, RM-07, RM-10 along with one check variety BARI sarisha-15 during Rabi season. BARI sarisha-15 was irradiated with 700 Gy Cobalt 60 (60Co) Gamma source and advanced mutant lines M6 generation of mustard mutant (RM-03, RM-07, RM-10) were evaluated along with the check variety BARI sarisha-15 using four different row spacings viz. 20cm, 25cm, 30cm and 35cm. The experiment was laid out in split-split plot design with three replications. Among the advance lines, RM-03 produced the highest seed yield (1.60 t ha-1) followed by RM-10 (1.50 t ha-1). Among different line spacing, 20cm showed highest seed yield (1.66 t ha-1). The interaction of mutant/variety and location revealed that the yield of RM-10 was the highest (1.54 t ha-1) at Rangpur. The interaction effect of line spacing and location showed that 25cm line spacing produced the maximum seed yield (1.68 t ha-1) in Magura followed by 20 cm (1.64 t ha-1) in Rangpur. The interaction effect of mutant and line spacing showed that mutant line RM-03 at 20 cm produced maximum seed yield (1.68 t ha-1) in Rangpur. The interaction effect of mutant/variety, line spacing and location showed that RM-10 produced the highest seed yield (1.73 t ha-1) at 20cm line spacing in Rangpur followed by RM-07 (1.66 t ha-1) at same spacing. Bangladesh J. Nuclear Agric, 37(1): 41-50, 2023
2
Powell, Arlie A., and Ed Tunnell. "EFFECT OF HYDROGEN CYANAMIDE (DORMEX) SPRAYS ON PEACH TREES SUFFERING FROM LACK OF WINTER CHILLING." HortScience 25, no. 8 (August 1990): 853e—853. http://dx.doi.org/10.21273/hortsci.25.8.853e.
Full textAbstract:
Lack of winter chilling (480 hrs. at or below 7.2°C by 02/28/89) occurred along Alabama's Gulf Coast in the winter of 1988-89. Varieties requiring 650 hours of chilling or more were under stress. To evaluate hydrogen cyanamide (HC), a product used world wide to replace part of some fruit plants chilling req., a study was conducted along the Gulf Coast using Bicentennial (700 hr.), Sentinel (850 hr.) and Loring (900 hr.) peach varieties. Full tree sprays (applied to drip with handgun) using 0, .5 and 1% a.i. plus .25% × 77 were applied 03/01/89. Fruit buds were dormant to slight swell when sprayed. HC greatly enhanced rate and % of leaf bud break at the 1% conc., for all varieties. Rate and % of flowering were significantly increased at 1% conc. in Loring and Sentinel but nearly all fruit dropped. Flowering, yield and fruit size of Bicentennial-were significantly improved at .5 and 1% conc. HC was effective in replacing lack of chilling in this variety.
3
Yakovenko, R. E., V. B. Ilyin, A. P. Savostyanov, I. N. Zubkov, A. V. Dulnev, and O. A. Semyonov. "Conversion of Liquefied Hydrocarbon Gases on Commercial Nickel Catalysts." Kataliz v promyshlennosti 19, no. 6 (November 14, 2019): 455–64. http://dx.doi.org/10.18412/1816-0387-2019-6-455-464.
Full textAbstract:
The two-step conversion of industrial liquefied hydrocarbon gases (LHG) on NIAP-07-01 (NKM-1) and NIAP-03-01 catalysts for the production of hydrogen-containing gases was investigated. The experiments were carried out in flow reactors with a fixed catalyst bed at a pressure of 0.1 MPa under the following conditions: temperature 350–450 °C, gas hourly space velocity (GHSV) 1000–3000 h–1, steam-gas ratio 4 : 1–8 : 1 (pre-reforming); and temperature 700 °C, GHSV 2000 h–1, air-gas ratio 1.2 : 1 (steam-air reforming). Under the studied conditions, the concentrations of components of the converted gas correspond to the equilibrium values calculated within the Peng-Robinson model. The conversion of methane homologs in the pre-reforming step was found to be virtually 100 %; therewith, the methane concentration reached 32–54 %, and that of hydrogen, 24–47 %. To prevent the formation of elemental carbon (carbonization), pre-reforming of hydrocarbon gases with a high methane equivalent should be performed at H2O : C > 2. In the two-step reforming, the yield of hydrogen-containing gas reaches 15.6 m3 from 1 m3 of the initial LHG with the hydrogen content 41.81 %, and the total content of CO and H2 exceeds 52 %.
4
NEWITT, S., A. J. ELLIOT, R. MORBEY, H. DURNALL, M. E. PIETZSCH, J. M. MEDLOCK, S. LEACH, and G. E. SMITH. "The use of syndromic surveillance to monitor the incidence of arthropod bites requiring healthcare in England, 2000–2013: a retrospective ecological study." Epidemiology and Infection 144, no. 11 (April 12, 2016): 2251–59. http://dx.doi.org/10.1017/s0950268816000686.
Full textAbstract:
SUMMARYClimate change experts predict the number of nuisance-biting arthropods in England will increase but there is currently no known surveillance system in place to monitor or assess the public health impact of arthropod bites. This retrospective ecological study utilized arthropod bites requiring healthcare from five national real-time syndromic surveillance systems monitoring general practitioner (GP) consultations (in-hours and out-of-hours), emergency department (ED) attendances and telephone calls to remote advice services to determine baseline incidence in England between 2000 and 2013 and to assess the association between arthropod bites and temperature. During summer months (weeks 20–40) we estimated that arthropod bites contribute a weekly median of ~4000 GP consultations, 750 calls to remote advice services, 700 ED and 1300 GP out-of-hours attendances. In all systems, incidence was highest during summer months compared to the rest of the year. Arthropod bites were positively associated with temperature with incidence rate ratios (IRRs) that ranged between systems from 1·03 [95% confidence interval (CI) 1·01–1·06] to 1·14 (95% CI 1·11–1·16). Using syndromic surveillance systems we have established and described baseline incidence of arthropod bites and this can now be monitored routinely in real time to assess the impact of extreme weather events and climate change.
5
Biron, P., I. Ray-Coquard, A. Le Cesne, S. Dussart, C. Goilliot, T. Bachelot, A. Thyss, E. Gilles, S. Chabaud, and J. Blay. "ELYPSE 2: A prospective randomized trial comparing filgrastim (G-CSF) in primary and secondary prophylaxis in patients (pts) at high risk for febrile neutropenia (FN)." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 8614. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.8614.
Full textAbstract:
8614 Background: FN is a frequent life-threatening consequence of cytotoxic chemotherapy (CT). G-CSF reduces the risk of FN, but primary (1ry) prophylaxis using G-CSF may be cost efficient only if FN incidence is ≥20%. The identification of pts at high risk for FN with simple criterias would be useful in clinical practice. Here we report a randomized phase II trial comparing G-CSF in 1ry vs 2ry prophylaxis in a high risk group of pts (based on our risk model JCO 1996;14:737, Br J Cancer 2003;88:181). Methods: Pts ≥18 years with solid tumors or NHL at high risk for FN after CT were incluable: these were pts with day 1 or day 5 lymphocytes (Ly) count ≤700/μL AND “high risk CT” (HRCT) In pts with d1 and d5 Ly ≤700/μL, the observed incidence of FN was 40% and 66% respectively G-CSF (300 to 480μg/d from d6–12) was randomized either as in 1ry prophylaxis (Arm 1), or as 2ry prophylaxis after FN (Arm 2). Primary endpoint was the rate of grade 4 FN. Hypothesis was a reduction of 40% of the risk of FN with 1ry prophylaxis. Results: Between 03/97 and 12/04, 137 pts were included in 7 centers. The median age was 53 years (range 18–80) with 54% males. Most frequent tumors were sarcomas (36%), breast carcinomas (18%), lymphomas (15%), head and neck carcinomas (10%), and lung carcinomas (6%). 23% patients had PS>1 at the first line of chemotherapy. No difference was observed in terms of duration of hospitalization or antibiotherapy. Median number of days of G-CSF administration was 14 days (0–24) vs 0 (0–17) days (p<0.0000). After the 1st course, grade 4 FN was 38% in Arm 2 (2ry prophylaxis) and 25% in Arm 1 (1ry prophylaxis), showing a 34% reduction of FN in arm 1 (p=0.14): 1ry prophylaxis was associated with a significant reduction of FN using logistic regression (p=0.04). Incidence of FN after the 2 course in pts receiving 2ry prophylaxis was 22%. Among the subgroup of pts with PS>2 and Ly ≤700/μL, (a group with a reported 20% risk for early death, Br J Cancer 2001;85:816), 2 of 8 patients (25%) died after the 1st course, vs 0/13 in the G-CSF group (p=0.05). This difference was not significant in the whole group. Conclusions: This study confirms that lymphopenic pts receiving HRCT are a high risk group of pts for FN for whom 1ry prophylaxis with G-CSF reduces the incidence of FN. [Table: see text]
6
Rahman, Rizki, and Sutrisno Sutrisno. "ANALISA KEKUATAN KOLOM GEDUNG RUMAH SAKIT TYPE C MEDAN LABUHAN PADA WILAYAH ZONA GEMPA YANG BERBEDA (STUDI KASUS)." Jurnal Riset Rekayasa Sipil 5, no. 1 (September 30, 2021): 18. http://dx.doi.org/10.20961/jrrs.v5i1.55468.
Full textAbstract:
<p>Indonesia is a country that is a often hit by disasters, this is due to the meeting of 4 tectonic plates of the earth. The city of Padang is right at the meeting between the Indo-Australian plate and Eurasia so that it puts the city of Padang as one of the cities prone to earthquakes. This research analyzes the type C hospital building that was originally designed in the Medan city location to be designed in Padang city with the aim to determine the strength of the structure and the need for the width of the column reinforcement in the building. The first step is to determine the spectral response value of the Padang region earthquake, a short period of 0.2 seconds Ss = 1,289 g and a period of 1 second S1 = 0.549 g. Second is calculating dead load, live load and static earthquake load equivalent to SNI 03-1726-2012 and force output in using ETABS software, and third is calculating the column reinforcement area requirements. The results of the analysis show that the width of the column reinforcement there is a difference = 4750.00 mm against field data = 6801.24 mm in the dimensions of the column 500 mm x 500 mm with a value of = 2051.24 mm and an increase in the value of the calculation reinforcement area in the 700 mm column x 700 mm is = 9800.00 mm from the field data = 9068.32 mm with a selection = 731.68 mm.</p>
7
Bonilla-Gómez, José Luis, Maribel Badillo-Alemán, Alfredo Gallardo-Torres, and Xavier Chiappa-Carrara. "Temporal variation, growth and natural mortality of two species of mojarras (Perciformes: Gerreidae) from a tropical coastal lagoon: La Carbonera, Yucatan, Mexico." Revista Ciencias Marinas y Costeras 5 (December 10, 2013): 57. http://dx.doi.org/10.15359/revmar.10-5.4.
Full textAbstract:
This study reports seasonal variation, growth parameters and natural mortality for Eucinostomus gula and Eucinostomus argenteus inhabiting La Carbonera, a tropical coastal lagoon on the northwestern coast of theYucatan Peninsula, Mexico. Specimens were collected between April 2009 and March 2010. A total of 2700organisms of E. gula (> 80% in rainy season ) and 1577 organisms of E. argenteus (>50% in dry season)were collected during the study period. Length-weight relationship (LWR) obtained was W = 8.323E-03Lt2.92 in E. argenteus and W = 7.314E-03 Lt2.92 in E. gula. Growth parameters of von Bertalanffy growthfunction (VBGF) by length frequency analysis were in E. argenteus: L∞ = 13.65 cm, k = 0.54 year-1 and t0= - 0.37 years; and in E. gula: L∞ = 12.60 cm, k = 0.68 year-1 and t0 = - 0.28 years. Additionally, estimatednatural mortality in E. gula was 1.50 year-1 and in E. argenteus was 1.9 year-1. This study presents the firstestimation for both species of model parameters, growth performance index and mortality for the Yucatan Peninsula, which is relevant for the proper implementation of conservation measures for E. gula and E. argenteus in an important coastal zone of the Yucatan Peninsula.Se reportan la variación temporal, los parámetros de crecimiento y la mortalidad natural para Eucinostomus gula y Eucinostomus argenteus que habitan en la laguna costera tropical La Carbonera, al noroeste de la península de Yucatán, México. Los especímenes fueron recolectados entre abril de 2009 a marzo de 2010. Un total de 2 700 organismos de E. gula (> 80% en la estación lluviosa) y 1 577 organismos de E. argenteus (> 50% en la estación seca) fueron recolectados durante el período de estudio. Se determinó la relación peso-longitud (RPL) como: P = 8.323E-03 Lt 2.92 en E. argenteus y P = 7.314E-03 Lt2.92 en E. gula. Para E. argenteus, los parámetros de crecimiento de la ecuación de crecimiento de von Bertalanffy (ECVB) fueron: L∞ = 13.65 cm, k = 0.54 año-1 y t0 = - 0.37 años; mientras que para E. gula fueron: L∞ = 12.60 cm, k = 0.68 año-1 y t0 = - 0.28 años. La mortalidad natural en E. gula fue 1.50 año-1 y en E. argenteus fue 1.9 año-1. Este estudio presenta la primera estimación para ambas especies de los modelos de crecimiento, el índice del desempeño de crecimiento y la mortalidad natural para la península de Yucatán, lo que es relevante para la adecuada implementación de medidas de conservación de E. gula y E. argenteus en una valiosa zona costera de la península de Yucatán.
8
Bonilla-Gómez, José Luis, Maribel Badillo-Alemán, Alfredo Gallardo-Torres, and Xavier Chiappa-Carrara. "Temporal variation, growth and natural mortality of two species of mojarras (Perciformes: Gerreidae) from a tropical coastal lagoon: La Carbonera, Yucatan, Mexico." Revista Ciencias Marinas y Costeras 5 (December 10, 2013): 57. http://dx.doi.org/10.15359/revmar.5.4.
Full textAbstract:
This study reports seasonal variation, growth parameters and natural mortality for Eucinostomus gula and Eucinostomus argenteus inhabiting La Carbonera, a tropical coastal lagoon on the northwestern coast of theYucatan Peninsula, Mexico. Specimens were collected between April 2009 and March 2010. A total of 2700organisms of E. gula (> 80% in rainy season ) and 1577 organisms of E. argenteus (>50% in dry season)were collected during the study period. Length-weight relationship (LWR) obtained was W = 8.323E-03Lt2.92 in E. argenteus and W = 7.314E-03 Lt2.92 in E. gula. Growth parameters of von Bertalanffy growthfunction (VBGF) by length frequency analysis were in E. argenteus: L∞ = 13.65 cm, k = 0.54 year-1 and t0= - 0.37 years; and in E. gula: L∞ = 12.60 cm, k = 0.68 year-1 and t0 = - 0.28 years. Additionally, estimatednatural mortality in E. gula was 1.50 year-1 and in E. argenteus was 1.9 year-1. This study presents the firstestimation for both species of model parameters, growth performance index and mortality for the Yucatan Peninsula, which is relevant for the proper implementation of conservation measures for E. gula and E. argenteus in an important coastal zone of the Yucatan Peninsula.Se reportan la variación temporal, los parámetros de crecimiento y la mortalidad natural para Eucinostomus gula y Eucinostomus argenteus que habitan en la laguna costera tropical La Carbonera, al noroeste de la península de Yucatán, México. Los especímenes fueron recolectados entre abril de 2009 a marzo de 2010. Un total de 2 700 organismos de E. gula (> 80% en la estación lluviosa) y 1 577 organismos de E. argenteus (> 50% en la estación seca) fueron recolectados durante el período de estudio. Se determinó la relación peso-longitud (RPL) como: P = 8.323E-03 Lt 2.92 en E. argenteus y P = 7.314E-03 Lt2.92 en E. gula. Para E. argenteus, los parámetros de crecimiento de la ecuación de crecimiento de von Bertalanffy (ECVB) fueron: L∞ = 13.65 cm, k = 0.54 año-1 y t0 = - 0.37 años; mientras que para E. gula fueron: L∞ = 12.60 cm, k = 0.68 año-1 y t0 = - 0.28 años. La mortalidad natural en E. gula fue 1.50 año-1 y en E. argenteus fue 1.9 año-1. Este estudio presenta la primera estimación para ambas especies de los modelos de crecimiento, el índice del desempeño de crecimiento y la mortalidad natural para la península de Yucatán, lo que es relevante para la adecuada implementación de medidas de conservación de E. gula y E. argenteus en una valiosa zona costera de la península de Yucatán.
9
Lim, Yong Cheol, Eunyoung Lee, and Jihye Song. "Outcomes of Bypass Surgery in Adult Moyamoya Disease by Onset Type." JAMA Network Open 7, no. 6 (June 6, 2024): e2415102. http://dx.doi.org/10.1001/jamanetworkopen.2024.15102.
Full textAbstract:
ImportanceMoyamoya disease (MMD) is a rare chronic cerebrovascular disease, and the outcomes of bypass management in adult patients remain controversial.ObjectiveTo categorize adult MMD based on asymptomatic, ischemic, and hemorrhagic onset and compare the outcomes (death, hemorrhagic stroke [HS], and ischemic stroke [IS]) of bypass surgery (direct or indirect) with those of conservative management.Design, Setting, and ParticipantsThis retrospective, nationwide, population-based longitudinal cohort study used Korean National Health Insurance Research data to identify adults (aged ≥15 years) with MMD who were diagnosed between January 1, 2008, and December 31, 2020, and followed up until December 31, 2021 (median follow-up, 5.74 [IQR, 2.95-9.42] years). A total of 19 700 participants (3194 with hemorrhagic, 517 with ischemic, and 15 989 with asymptomatic MMD) were included. Data were analyzed from January 2 to April 1, 2023.ExposuresBypass surgery and conservative management.Main Outcomes and MeasuresDeath constituted the primary outcome; secondary outcomes consisted of HS or IS. Kaplan-Meier survival curve and Cox proportional hazards regression analysis were applied. The propensity score–matching and stratified analyses were performed to control covariate effects.ResultsA total of 19 700 patients (mean [SD] age, 45.43 [14.98] years; 12 766 [64.8%] female) were included. Compared with conservative management, bypass was associated with a reduced risk of death (adjusted hazard ratio [AHR], 0.50 [95% CI, 0.41-0.61]; P &lt; .001) and HS (AHR, 0.36 [0.30-0.40]; P &lt; .001) in hemorrhagic MMD; reduced risk of IS (AHR, 0.55 [95% CI, 0.37-0.81]; P = .002) in ischemic MMD; and reduced risk of death (AHR, 0.74 [95% CI, 0.66-0.84]; P &lt; .001) in asymptomatic MMD. However, bypass was associated with an increased risk of HS (AHR, 1.76 [95% CI, 1.56-2.00]; P &lt; .001) in asymptomatic MMD. Both direct and indirect bypass demonstrated similar effects in hemorrhagic and asymptomatic MMD, except only direct bypass was associated with a reduced risk of IS (AHR, 0.52 [95% CI, 0.33- 0.83]; P = .01) in ischemic MMD. After stratification, bypass was associated with a reduced risk of death in patients younger than 55 years with ischemic (AHR, 0.34 [95% CI, 0.13- 0.88]; P = .03) and asymptomatic (AHR, 0.69 [95% CI, 0.60-0.79]; P &lt; .001) MMD, but an increased risk of HS in patients 55 years or older with ischemic MMD (AHR, 2.13 [95% CI, 1.1-4.16]; P = .03).Conclusions and RelevanceThe findings of this cohort study of bypass outcomes for patients with MMD emphasize the importance of tailoring management strategies in adult patients based on onset types.
10
Nurhaiza, Nurhaiza, and Nova Purnama Lisa. "Optimalisasi Pencahayaan Alami pada Ruang." Jurnal Arsitekno 7, no. 7 (February 21, 2019): 32. http://dx.doi.org/10.29103/arj.v7i7.1234.
Full textAbstract:
Abstract Natural lighting is the lighting obtained from direct sunlight, where the light is obtained in the morninguntil late afternoon. According to SNI 03-2396-200, natural lighting during the day can be good in a span of solarorientation starting at 8:00 pm until 16: 00 pm with equitable distribution of incoming light in the room and didnot leave annoying glare effects in the use of lighting natural, regardless of the quality and distribution of lightthat enters the building through a window and orientation of openings. The wider the aperture, the more light thatenters the room. It is necessary to control the amount of light coming into the room. The research used isquantitative method by using mathematical models, with the measurement process, using a formula to obtainaccurate data. The object of research and observations in Architecture Program Faculty Building University ofMalikussaleh, Lhokseumawe Aceh. Observation is by direct observation to see the condition of natural lighting inclassrooms, measurements the extent of the classroom. Then collect some measurement data among other things,measure the light intensity at the lecture hall by using Luxmeter, calculate the intensity of light at the lecture hallby factors sky with measuring point main and the measuring point side and the comparative results of themeasurement of light intensity of the lighting level the average recommended. The results show, a lecture hall inthe building Prodi architecture has three floors, which have 4 lecture room on floors 1 and 2, 2 room studioregular on floors 1, 2 lab computer room on the floor and 2 studio design room on the 2nd floor. also of coursethe building also has other equipment such as administration room, warehouse and other supporting facilities.But for the third floor untapped dikarenaka still in the process of renovation. The results of observations obtainedintensity of natural light on the 1st floor and 2nd floor Architecture Program building University of Malikussalehbased on the measurement of light intensity using the luxmeter, the obtained data is that the rooms was not inaccordance with the standards of an average lighting is recommended by ISO 2000 for classrooms -03 250 luxand 700 lux.Key word: Natural Lighting, Light Intensity, Lux meters, ISO 2000, SNI 03-2396-200
11
Dadzie, Donald Kwabena, and A. K. Kaliluthin. "Implications of Palm Kernel Shell-Filled Plastic Bottles on the Structural Behavior of Concrete Slab." Civil Engineering Journal 9, no. 3 (March 1, 2023): 731–51. http://dx.doi.org/10.28991/cej-2023-09-03-016.
Full textAbstract:
The implications of palm kernel shell (PKS)-filled plastic bottles on the structural behaviour of concrete slabs were carried out by comparing the flexural performance of conventional solid concrete slabs to concrete slabs incorporated with plastic bottles filled with palm kernel shells and placed vertically, horizontally, and diagonally at the neutral axis of the slab as per Bubble Deck Slab technology. One-way slab specimens of size 700 × 300 × 150 mm thick were produced and subjected to a four-point flexural load test. Findings from the study indicated that: (1) The PKS-filled bottle slabs deflected more than the conventional solid slab, hence making them more flexible than the conventional slabs and, as such, giving the occupants enough time to evacuate. (2) The flexural strengths of the PKS-filled bottle slabs exceeded those of conventional slabs by 18.3% and 10.9%, respectively, for five and ten percentages of the volume of slab concrete occupied. (3) The condition of the PKS, either dry or saturated, coupled with the bottle arrangement (either vertical, horizontal, or diagonal), does not, however, cause any significant change to the performance of the PKS filled bottle slabs in terms of load carrying capacity, deflection, and strength. Doi: 10.28991/CEJ-2023-09-03-016 Full Text: PDF
12
Bogo, Amauri, Ricardo Trezi Casa, Luis Sangoi, and Paulo Tarcísio Domatos Borba. "The influence of low temperatures on the incidence of sugary disease on sorghum." Ciência Rural 36, no. 2 (April 2006): 397–403. http://dx.doi.org/10.1590/s0103-84782006000200007.
Full textAbstract:
The relationship between pre-flowering climatic conditions and sugary disease incidence was quantified in grain and forage sorghum genotypes at two sowing periods (mid November and mid December). The trials were carried out over the 2001/02 and 2002/03 growing seasons, in Lages, Santa Catarina State. Four commercial male-fertile sorghum hybrids (BR 600-forrage, BR 700-grain, BR 701-forage/silage and BR 800-forage) and one male-sterile inbred line (BR 001-A) were evaluated. When each genotype reached the flowering stage, 50 panicles were marked and sprayed with a suspension of Claviceps africana (1,000 spores mL-1). Air temperature, humidity and rainfall were recorded through out the growing cycle. Low temperatures three to four weeks prior to flowering, increased susceptibility. At both sowing periods, average night temperatures lower than 15°C during the critical period of pre-flowering turned the fertile hybrids as susceptible as the male-sterile inbred to ergot infection. The tested hybrids differed in their ability to tolerate pre-flowering cold stress. Seed set in uninoculated heads under pollination bags was also reduced, suggesting that increased susceptibility to sugary disease was the result of low temperature induced sterility.
13
Allen, S. L., J. E. Kolitz, A. S. Lundberg, R. L. Capizzi, and D. R. Budman. "Clinical and cytogenetic responses to amonafide in secondary acute myeloid leukemia (AML)." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 6584. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.6584.
Full textAbstract:
6584 Background: Patients (pts) with secondary AML (AML following an antecedent hematologic disorder or following known exposure to leukemogenic agents) are often elderly, with comorbid illness, and have a dismal prognosis. Secondary AML responds poorly to standard chemotherapy, with low response rates and short durations of remission. Amonafide (Am) is an ATP independent topoisomerase 2 inhibitor that in prior clinical studies had myelosuppression as the dose-limiting toxicity. Two phase 1 trials evaluated Am as either a single agent or in combination with ara-C in pts with relapsed/refractory or secondary AML. This retrospective review was performed to assess the activity of Am specifically in pts with secondary AML. Methods: In study AM-03, 5 pts with secondary AML were treated with a fixed dose (1000, 1100, or 1400 mg/m2/day) of Am IV over 2 hrs daily × 5. In study AM-04, 15 pts with secondary AML were treated with ara-C 200 mg/m2/day CIV days 1–7 and a fixed dose (600, 700 or 800 mg/m2/d) of Am IV over 2 hrs daily on days 1–5. All clinical trial data were reviewed for assessment of hematological and cytogenetic response. Results: Across the two studies, 10 of 20 (50%) pts responded to Am (9 CR, 1 CRi). In study AM-03 (Am monotherapy), 3 of 5 (60%) pts responded, with median duration of response 7.5 months (range 2.5 - 8). None of these 3 pts received additional post-remission therapy. In study AM-04 (Am + ara-C), 7 of 15 pts (47%) responded, with median duration of response 8 months (range 1 ¾ to >60 months). 4 of these 7 pts received additional post-remission therapy. Cytogenetic analysis prior to and following Am therapy was available for 9 of the 10 pts with secondary AML who responded to Am in the 2 studies. Cytogenetics were abnormal prior to Am therapy in 5 of these 9 pts, 3 (60%) of whom achieved cytogenetic CR. Conclusions: Am shows significant activity in secondary AML, both as monotherapy and in combination with ara-C. A phase 2 trial of Am + ara-C in pts with secondary AML is currently enrolling patients. [Table: see text]
14
Ikegawa, Kazutaka, Kengo Miyara, Yuya Tachikawa, Stephen Matthew Lyth, Junko Matsuda, and Kazunari Sasaki. "Performance and Durability of Solid Oxide Electrolysis Cell Air Electrodes Prepared By Various Conditions." ECS Meeting Abstracts MA2022-02, no. 47 (October 9, 2022): 1782. http://dx.doi.org/10.1149/ma2022-02471782mtgabs.
Full textAbstract:
Introduction Fuel electrode materials are important for achieving higher performance and durability of Solid Oxide Fuel Cell (SOFC), Solid Oxide Electrolysis Cell (SOEC), and Reversible Solid Oxide Cells (r-SOCs). On the other hand, the air electrode also faces performance and durability issues. For example, the diffusion of Sr ions from the air electrode materials has been reported.1, 2 In SOECs, if electrolysis can be performed at a thermoneutral potential balancing heat absorption by electrolysis and heat generation by the internal resistance of the electrolysis cell, hydrogen can be generated theoretically without heat supply. The purpose of this study is to evaluate the electrochemical performance and durability of the SOECs by conducting electrolysis performance tests of LSCF-based air electrodes with different preparation conditions, and electrolysis durability tests at the thermoneutral potential. Experimental Each test was conducted using a cell with a scandia-stabilized zirconia electrolyte (ScSZ, 200 µm thick) as a substrate. For the fuel electrode, Ni-GDC co-impregnated fuel electrode was used3. A mixture of Ni(NO3)2･6H2O, Gd(NO3)3･6H2O, and Ce(NO3)3･6H2O was impregnated into the porous LST-GDC framework, a mixture of LST powder (La0.1Sr0.9TiO3) and GDC powder (Gd0.9Ce0.1O₃). LSCF, (La0.6Sr0.4)(Co0.2Fe0.8)O3, was used for the air electrodes. GDC was inserted between the LSCF layer and the electrolyte plate as a buffer layer. In fabricating air electrodes, four types of air electrodes were applied, at shown in Table 1. For the electrochemical measurements of the air electrodes, Pt reference electrode was attached to the electrolyte on the fuel electrode side, and the voltage terminals of the electrochemical measurement system were connected between the reference electrode and the air electrode to measure air electrode voltage. In the performance tests, the voltage (potential) and impedance of the air electrode were measured at operating temperatures of 800°C, 750°C, and 700°C. In the durability tests, the air electrode was maintained at thermoneutral potentials at 800°C and 700°C (1.286 V and 1.283 V, respectively), and the voltage and impedance of the air electrodes were measured before and after the durability tests to evaluate the degradation of the air electrodes. Results and discussion Figure 1 shows the air electrode voltage obtained from the performance tests at each operating temperature for the four types of air electrodes shown in Table 1. First, regarding the dependence of the electrolysis performance on operating temperature, an increase in air electrode voltage (degradation of the air electrode) was found at 800°C.The increase in air electrode voltage with current density was almost linear, but at lower operating temperatures, the increase in air electrode voltage at lower current densities becomes larger. In other words, the I-V curve was rather ohmic at 800°C, but non-ohmic at 700°C. Figure 2 shows the results of an 80-hour durability test at different temperatures. The current density of the cell corresponding to the thermoneutral potential was -0.298 Acm-2 when operated at 800°C and -0.018 Acm-2 when operated at 700°C.The degradation rate was calculated from the difference in air electrode voltage before and after the performance and durability test at these current densities: 0.172% at 800°C and 0.792% at 700℃. The degradation rate increased as the operating temperature decreased in the SOEC mode, despite the low current density. Microstructural observation of the air electrode after the durability test showed that Sr diffused to the LSCF/GDC interface similar to SOFCs mode4, and that the diffusion of Sr was accelerated at 700°C. In addition, Co diffusion was also observed. Such diffusion may occur during LSCF firing process and/or during SOEC operation. More detailed investigation is in progress. Acknowledgements This research was supported in part by NEDO (New Energy and Industrial Technology Development Organization). We thank all parties involved. References (1) V. Subotić, S. Futamura, G. F. Harrington, J. Matsuda, K. Natsukoshi, and K. Sasaki, J. Power Sources, 492, 229600 (2021). (2) S. P. Simner, M. D. Anderson, M. H. Engelhard, and J. W. Stevenson, Electrochem. Solid-State Lett., 9 A478 (2006). (3) K. Natsukoshi, K. Miyara, Y. Tachikawa, J. Matsuda, S. Taniguchi, G. F. Harrington, and K. Sasaki, ECS Trans., 03, 203 (2021). (4) S. Kanae, Y. Toyofuku, T. Kawabata, Y. Inoue, T. Daio, J. Matsuda, J,-T. Chou, Y. Shiratori, S. Taniguchi, and K. Sasaki, ECS Trans., 68, 2463 (2015). Figure 1
15
Butali, A., P. A. Mossey, W. L. Adeyemo, P. A. Jezewski, C. K. Onwuamah, M. O. Ogunlewe, V. I. Ugboko, et al. "Genetic Studies in the Nigerian Population Implicate an MSX1 Mutation in Complex Oral Facial Clefting Disorders." Cleft Palate-Craniofacial Journal 48, no. 6 (November 2011): 646–53. http://dx.doi.org/10.1597/10-133.
Full textAbstract:
Background Orofacial clefts are the most common malformations of the head and neck, with a worldwide prevalence of 1 in 700 births. They are commonly divided into CL(P) and CP based on anatomic, genetic, and embryologic findings. A Nigerian craniofacial anomalies study (NigeriaCRAN) was set up in 2006 to investigate the role of gene-environment interaction in the origin of orofacial clefts in Nigeria. Subjects and Methods DNA isolated from saliva from Nigerian probands was used for genotype association studies and direct sequencing of cleft candidate genes: MSX1, IRF6, FOXE1, FGFR1, FGFR2, BMP4, MAFB, ABCA4, PAX7, and VAX1, and the chromosome 8q region. Results A missense mutation A34G in MSX1 was observed in nine cases and four HapMap controls. No other apparent causative variations were identified. Deviation from Hardy Weinberg equilibrium (HWE) was observed in these cases ( p = .00002). A significant difference was noted between the affected side for unilateral CL ( p = .03) and bilateral clefts and between clefts on either side ( p = .02). A significant gender difference was also observed for CP ( p = .008). Conclusions Replication of a mutation previously implicated in other populations suggests a role for the MSX1 A34G variant in the development of CL(P).
16
LAZAREVICH, ALISON K., DOUGLAS A. OURSLER, and DONALD D. DUNCAN. "BACKGROUND CHARACTERIZATION WITH A SCANNED FOURIER TRANSFORM SPECTROMETER." International Journal of High Speed Electronics and Systems 18, no. 03 (September 2008): 613–25. http://dx.doi.org/10.1142/s0129156408005618.
Full textAbstract:
Background scene characterization in the long wave infrared (LWIR) region of the electromagnetic spectrum is of particular interest for simulating the operational environment of passive standoff chemical detection systems. In conjunction with collections of local metrological data and temperature and water vapor profiles, spectrally resolved LWIR imagery, acquired using a scanned Fourier Transform Spectrometer, and boresighted visible imagery were collected during Fall 2005. Resulting spectra in the 700 – 1450 cm−1 frequency range were analyzed to provide estimates of the foreground/background temperature differential that can then be used as a metric to assess the information content in the resulting IR imagery. Measurements were performed at two geographical sites and over 100 GBs of raw data were accumulated. Through spatio-temporal analysis of the resulting temperature differential maps, we have derived strategies for optimizing scan patterns. These optimized strategies attempt to minimize the amount of redundant data thus providing shorter inter-sample times for temporally varying portions of the scene. Considerations include the first and second order spatial and temporal statistics as well as information content as quantified by average pixel entropy. This research was financed by the U.S. Army Joint Project Manager for Nuclear, Biological, and Chemical Contamination Avoidance under contract number N00024-03-D-6606.
17
Shrestha, Sajan, Saraswati Shrestha, Sangeeta Maharjan, and Ram P. Regmi. "Boundary Layer Characteristics over the Central Area of the Kathmandu Valley as Revealed by Sodar Observation." Journal of Institute of Science and Technology 20, no. 1 (November 25, 2015): 28–35. http://dx.doi.org/10.3126/jist.v20i1.13907.
Full textAbstract:
The characteristic behavior of prevailing boundary layer over the central area of the Kathmandu valley was continuously monitored by deploying a monostatic flat array sodar during the period of 03 to 16 March 2013. Diurnal variation of wind and mixing layer height were chosen to describe the boundary layer activities over the area by considering the day of 12 March 2013 as the representative day for the period of observation. The study shows that central area of the valley remains calm or windless under stable stratification throughout the night and early morning frequently capped by northeasterly or easterly wind aloft. Strong surface level thermal inversion prevails during the period up to the height of 80m above the surface. This inversion tends to lift up as the morning progresses and reaches to the height of 875 m or so close to the noontime. Intrusion of regional winds as westerly/northwesterly and the southerly/southwesterly from the western and southwestern low-mountain passes and the river gorge in the afternoon tends to reduce the noontime mixing layer height to about 700 m. The diurnal variation of wind and mixing layer height suggest that Kathmandu valley possesses a poor air pollution dispersion power and hence the valley is predisposed to high air pollution potential.Journal of Institute of Science and Technology, 2015, 20(1): 28-35
18
Schott, Anne F., Sara Hurvitz, Cynthia Ma, Erika Hamilton, Rita Nanda, George Zahrah, Natasha Hunter, et al. "Abstract GS3-03: GS3-03 ARV-471, a PROTAC® estrogen receptor (ER) degrader in advanced ER-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer: phase 2 expansion (VERITAC) of a phase 1/2 study." Cancer Research 83, no. 5_Supplement (March 1, 2023): GS3–03—GS3–03. http://dx.doi.org/10.1158/1538-7445.sabcs22-gs3-03.
Full textAbstract:
Abstract Background: ARV-471 is a selective, orally administered PROteolysis TArgeting Chimera (PROTAC®) protein degrader that targets wild-type and mutant ER. ARV-471 is being evaluated in patients with ER+/HER2- locally advanced or metastatic breast cancer in a first-in-human phase 1/2 study (NCT04072952). In the phase 1 dose escalation, ARV-471 monotherapy (dose range: 30–700 mg total daily dose) showed a manageable safety profile in patients who had previously received endocrine therapy and a cyclin-dependent kinase (CDK) 4/6 inhibitor. The clinical benefit rate (CBR; rate of confirmed complete or partial response or stable disease ≥24 weeks) was 40% (95% CI: 26–56) in 47 evaluable patients. The phase 2 expansion portion of the study (VERITAC) evaluated 2 doses of ARV-471.Methods: In VERITAC, ARV-471 monotherapy was administered at doses of 200 mg once daily (QD) or 500 mg QD to patients with ER+/HER2- locally advanced/metastatic breast cancer who had received ≥1 prior endocrine therapy for ≥6 months, ≥1 CDK4/6 inhibitor, and ≤1 chemotherapy regimen. The primary endpoint of CBR was evaluated in patients enrolled ≥24 weeks prior to the data cutoff. Results: As of June 6, 2022, 71 patients received ARV-471 (200 mg QD [n=35]; 500 mg QD [n=36]) in VERITAC. Across all treated patients, 69 (97.2%) were female and median age was 60 y (range: 41–86). Patients had received a median of 4 prior regimens in all settings (range: 1–10); 100% had prior CDK4/6 inhibitors, 78.9% had prior fulvestrant, and 73.2% had prior chemotherapy. ARV-471 was well tolerated at both doses, with most treatment-related adverse events (TRAEs) grade 1/2; the most common TRAEs were fatigue and nausea (Table). In all, 3 patients (1 in the 200 mg QD cohort and 2 in the 500 mg QD cohort) discontinued ARV-471 due to treatment-emergent adverse events (TEAEs); 3 patients had ARV-471 dose reductions due to TEAEs (all from 500 mg QD to 400 mg QD). CBR was 37.1% (95% CI: 21–55) in 35 evaluable patients treated at 200 mg QD and 38.9% (95% CI: 23–57) in 36 evaluable patients treated at 500 mg QD. CBR in evaluable patients with mutant ESR1 in the 200 mg QD (n=19) and 500 mg QD (n=22) cohorts was 47.4% (95% CI: 24–71) and 54.5% (95% CI: 32–76), respectively. Conclusions: In the phase 2 VERITAC expansion cohorts of patients with ER+/HER2- locally advanced/metastatic breast cancer and prior CDK4/6 inhibitor treatment, ARV-471 monotherapy showed evidence of clinical activity based on CBR, which was further enhanced in the subgroup with ESR1 mutations. The manageable AE profile observed in the phase 1 portion of the study was maintained during cohort expansion at doses of 200 mg QD and 500 mg QD. Additional analyses are ongoing.Table. TRAEs reported in ≥10% of patients overall aNo grade 3/4 TRAE occurred in >1 patient. AST=aspartate aminotransferase Citation Format: Anne F. Schott, Sara Hurvitz, Cynthia Ma, Erika Hamilton, Rita Nanda, George Zahrah, Natasha Hunter, Antoinette R. Tan, Melinda Telli, Jesus Anampa Mesias, Rinath Jeselsohn, Pamela Munster, Haolan Lu, Richard Gedrich, Cecile Mather, Janaki Parameswaran, Hyo S. Han. GS3-03 ARV-471, a PROTAC® estrogen receptor (ER) degrader in advanced ER-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer: phase 2 expansion (VERITAC) of a phase 1/2 study [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr GS3-03.
19
Bujold, Alexis, Christine A. Massey, John J. Kim, James Brierley, Charles Cho, Rebecca K. S. Wong, Rob E. Dinniwell, et al. "Sequential Phase I and II Trials of Stereotactic Body Radiotherapy for Locally Advanced Hepatocellular Carcinoma." Journal of Clinical Oncology 31, no. 13 (May 1, 2013): 1631–39. http://dx.doi.org/10.1200/jco.2012.44.1659.
Full textAbstract:
Purpose To describe outcomes of prospective trials of stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC). Patients and Methods Two trials of SBRT for patients with active HCC unsuitable for standard locoregional therapies were conducted from 2004 to 2010. All patients had Child-Turcotte-Pugh class A disease, with at least 700 mL of non-HCC liver. The SBRT dose range was 24 to 54 Gy in six fractions. Primary end points were toxicity and local control at 1 year (LC1y), defined as no progressive disease (PD) of irradiated HCC by RECIST (Response Evaluation Criteria in Solid Tumors). Results A total of 102 patients were evaluable (Trial 1, 2004 to 2007: n = 50; Trial 2, 2007 to 2010: n = 52). Underlying liver disease was hepatitis B in 38% of patients, hepatitis C in 38%, alcohol related in 25%, other in 14%, and none in 7%. Fifty-two percent received prior therapies (no prior sorafenib). TNM stage was III in 66%, and 61% had multiple lesions. Median gross tumor volume was 117.0 mL (range, 1.3 to 1,913.4 mL). Tumor vascular thrombosis (TVT) was present in 55%, and extrahepatic disease was present in 12%. LC1y was 87% (95% CI, 78% to 93%). SBRT dose (hazard ratio [HR] = 0.96; P = .02) and being in Trial 2 (HR = 0.38; P = .03) were associated with LC1y on univariate analysis. Toxicity ≥ grade 3 was seen in 30% of patients. In seven patients (two with TVT PD), death was possibly related to treatment (1.1 to 7.7 months after SBRT). Median overall survival was 17.0 months (95% CI, 10.4 to 21.3 months), for which only TVT (HR = 2.47; P = .01) and being in Trial 2 (HR = 0.49; P = .01) were significant on multivariate analysis. Conclusion These results provide strong rationale for studying SBRT for HCC in a randomized trial.
20
Oliveira, Ademar P., Daniel S. Ferreira, Caciana C. Costa, Analice F. Silva, and Edna Ursulino Alves. "Uso de esterco bovino e húmus de minhoca na produção de repolho híbrido." Horticultura Brasileira 19, no. 1 (March 2001): 70–73. http://dx.doi.org/10.1590/s0102-05362001000100014.
Full textAbstract:
Comparou-se a eficácia do esterco bovino e húmus de minhoca na produção de repolho, híbrido Matsukaze, em experimento realizado no Centro de Ciências Agrárias da UFPB, Areia, de 10/12/97 a 05/03/98. Os tratamentos utilizados foram 20; 30; 40; 50 e 60 t/ha de esterco bovino e 10; 15; 20; 25 e 30 t/ha de húmus de minhoca e tratamento testemunha (sem matéria orgânica). O delineamento experimental utilizado foi o de blocos casualizados com onze tratamentos distribuídos em esquema fatorial (5 x 2) + 1, em quatro repetições. Foram avaliados o diâmetro longitudinal, transversal, índice de formato e compacidade da cabeça, peso médio e produção total de cabeças. A dose de 46,0 t/ha de esterco bovino e 29,0 t/ha de húmus de minhoca resultaram em maiores diâmetros longitudinais na cabeça de repolho (13 e 12 cm, respectivamente). A dose de 47,0 t/ha de esterco bovino e 20,0 t/ha de humus de minhoca proporcionaram a formação de cabeças com maiores diâmetros transversais (13 e 11 cm, respectivamente). Todas as doses de esterco bovino induziram a formação de cabeças mais uniformes e compactas, enquanto a dose de 20 t/ha de húmus de minhoca propiciou a formação de cabeças desuniformes de baixa aceitação comercial. A dose de 41,0 t/ha de esterco bovino promoveu máximo peso médio (900 g) e máxima produtividade (47,0 t/ha) de cabeças, enquanto as doses de 27,0 e 29,0 t/ha de húmus foram responsáveis pelo peso médio máximo (700 g) e máxima produtividade (38,0 t/ha), respectivamente.
21
Rustam, Jayadi, Andi Hamdillah, and Nursyahran. "Genetic Diversity of Panulirus Versicolor in the Waters of Barrang Caddi Island, Makassar Strait, South Sulawesi, Indonesia." International Journal on Advanced Science, Engineering and Information Technology 14, no. 3 (June 18, 2024): 986–92. http://dx.doi.org/10.18517/ijaseit.14.3.19938.
Full textAbstract:
Barong shrimp or lobster (Panulirus versicolor) is a fishery commodity with high economic value and great demand. This study aims to determine the genetic characteristics of Panulirus versicolor at the fishing location in the waters of Barrang Caddi Island, Makassar Strait, using primers LCO-1490F and HCO-2198R. Genomic DNA extraction was performed using a Quick-DNA Tissue Miniprep Kit for total isolation. For DNA purity, the elution buffer utilized in this research was specifically selected for its suitability for PCR amplification with KOD FX Neo, providing optimal conditions for efficient genetic analysis. The primary genes used were LCO-1490F with primers GGT CAA CAA ATC ATA AAG ATA TTG G, and HCO-2198R with TAA ACT TCA GGG TGA CCA AAA AAT CA. The study utilized a 1% agarose gel in a 1X TBE buffer at 50 voltage for 45 minutes to move the total DNA and PCR products. The analysis results at sampling stations 0.2-03 showed increasingly smaller genetic distances. Based on the results of BLASTn analysis, each station had the same type of Panulirus versicolor with a similarity of 99-100%. The morphological characteristics included a carapace with a black spot and black and white lines on each abdominal segment. The analysis of genetic variation in the lobster population on Barrang Caddi Island using primers LCO-1490F and HCO-2198R obtained a DNA fragment of 700 bp. The population of Panulirus versicolor lobster on Barrang Caddi Island showed a high level of similarity or low diversity.
22
Bardia, Aditya, Kevin Kalinsky, Junji Tsurutani, Erika Hamilton, Joo Hyuk Sohn, Kyong Hwa Park, Yeon Hee Park, et al. "Abstract OT1-03-04: Datopotamab deruxtecan (Dato-DXd), a TROP2 antibody-drug conjugate, vs investigators’ choice of chemotherapy in previously-treated, inoperable or metastatic HR+/HER2– breast cancer: TROPION-Breast01." Cancer Research 83, no. 5_Supplement (March 1, 2023): OT1–03–04—OT1–03–04. http://dx.doi.org/10.1158/1538-7445.sabcs22-ot1-03-04.
Full textAbstract:
Abstract Background: Chemotherapy is the main treatment in patients with pre-treated endocrine-resistant HR+/HER2– metastatic breast cancer, but has limited efficacy and substantial toxicities. The antibody-drug conjugate Dato-DXd consists of a humanized IgG1 mAb targeting TROP2 attached via a stable cleavable linker to a topoisomerase I (TopI) inhibitor payload. Heavily pre-treated patients with metastatic triple-negative breast cancer in the TROPION-PanTumor01 (NCT03401385) study of Dato-DXd showed a manageable safety profile and highly encouraging objective response rates (ORR by blinded independent central review [BICR]: 34% in all patients; 52% in patients treatment-naïve to TopI inhibitor-based therapies). The metastatic HR+/HER2– breast cancer cohort of TROPION-PanTumor01 has completed enrollment (n=41); data are currently maturing. Trial design: TROPION-Breast01 (NCT05104866) is an ongoing, global, phase 3, open-label, randomized trial evaluating efficacy and safety of Dato-DXd vs investigators’ choice of chemotherapy (ICC) in patients with inoperable or metastatic HR+/HER2– breast cancer. Patients (n≈700) are randomized 1:1 to Dato-DXd 6 mg/kg IV Q3W or ICC (eribulin, capecitabine, vinorelbine, or gemcitabine) until progression. Adults with an ECOG performance status of 0–1, who experienced progression on or are unsuitable for endocrine therapy, and received 1–2 prior lines of standard-of-care chemotherapy in the inoperable or metastatic setting are eligible. Monotherapy treatment with inhibitors of mTOR, PD-[L]1, CDK4/6 and PARP do not count as prior chemotherapy lines. Patients must have ≥1 measurable lesion per RECIST 1.1 and an archival or fresh formalin-fixed and paraffin-embedded tumor sample. Clinically inactive brain metastases are permitted. Dual primary endpoints are progression-free survival (PFS) by BICR, and overall survival. Secondary endpoints include PFS per investigator, ORR, disease control rate, patient-reported outcomes, and Dato-DXd pharmacokinetics and immunogenicity. Exploratory endpoints include TROP2 expression and exposure–efficacy relationship. Patients are stratified by number of prior chemotherapy lines, prior CDK4/6 inhibitor use, and region. At the time of writing 236 patients have been enrolled across 19 countries. Citation Format: Aditya Bardia, Kevin Kalinsky, Junji Tsurutani, Erika Hamilton, Joo Hyuk Sohn, Kyong Hwa Park, Yeon Hee Park, Seock-Ah Im, Keun Seok Lee, Daisy Dastur, Vincent Haddad, Sabrina Khan, Binghe Xu, Barbara Pistilli, Hope Rugo. Datopotamab deruxtecan (Dato-DXd), a TROP2 antibody-drug conjugate, vs investigators’ choice of chemotherapy in previously-treated, inoperable or metastatic HR+/HER2– breast cancer: TROPION-Breast01 [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr OT1-03-04.
23
Blasdel, Carolyn, Yanfeng Wang, Theodore Lagattuta, Brian Druker, Laurie Letvak, and Merrill Egorin. "Therapeutic Drug Monitoring of Imatinib and Impact on Clinical Decision Making." Blood 108, no. 11 (November 16, 2006): 4820. http://dx.doi.org/10.1182/blood.v108.11.4820.4820.
Full textAbstract:
Abstract OBJECTIVES: Imatinib (IM) has demonstrated durable clinical efficacy in the majority of chronic myeloid leukemia (CML) patients. Optimal response may be influenced by multiple innate and external factors, some of which may be controlled by monitoring plasma concentrations of the drug. This abstract reports 6 cases where analyzing plasma IM trough concentrations (Cmin) in patients treated with three commonly used IM doses (400, 600, and 800 mg daily) influenced clinical decision making. METHODS: IM trough blood samples were collected at a time before that day’s IM dosing. Plasma concentrations of IM were determined by a validated LC/MS/MS method. RESULTS: In large population studies of CML patients enrolled in Phase I, II, and III clinical trials, the mean Cmin levels of IM at 400 mg qd, 600 mg qd, and 400 mg bid doses were: 981 (±543, 55%, n=394), 1572 (±1032, 66%, n=14), and 3479 (±1264, 36%, n=14) ng/mL, respectively. Large inter-patient variability was shown at all three doses. Of the 6 cases detailed in the table below, 4 (ID 1, 3, 4, and 5) had dose reduction due to tolerability concerns with subsequent improvement of symptoms following dose adjustment. One patient (ID 2) had a dose increase because of a poor qRT-PCR response. Another (ID 6) had a dose increase due to low plasma IM exposure resulting from drug-drug interaction with phenytoin, a known inducer of CYP3A4 (the major metabolizing isozyme for IM). After dose adjustment, all six patients showed good clinical response to IM treatment. The new mean Cmin value in these patients was 2000 (±471) ng/mL, representing a 24% coefficient of variability. CONCLUSIONS: Although the data is limited, IM drug monitoring proved useful in managing tolerability, lack of efficacy, adherence or potential drug interactions that modulate imatinib drug concentrations. More prospective studies are needed to demonstrate the value of IM drug monitoring in routine clinical practice. Patient ID Age, Sex CML Stage IM Daily Dose 1st Cmin (ng/mL) Reason for Dose Change New Dosing Regimen New Cmin (ng/mL) CP, chronic phase1 1 54, f CP 200 mg bid, Jan 03 3048, Sep 05 transfusion-dependent, anemia, Sep 05 300 mg, Oct 05 2130, Jan 06 2 9, f CP 300 mg, Jan 05 not done qRT-PCR 0.016, Jan 06 400 mg, Jan 06 2341, Jul 06 3 13, f CP 300 mg bid, May 05; 700 mg, Aug 05; 600 mg, Sep 05 1966, Feb 06 nausea, fatigue, arthralgias, myalgia, ongoing 400 mg, Mar 06 1222, May 06 4 67, f CP 400 mg, Feb 05 not done myelosuppression, Mar 05 200 mg, Mar 05 1928, May 06 5 53, f CP 400 mg, Apr 03; 600 mg, May 03; 800 mg, Jul 04 not done inflammatory pulmonary reaction with shortness of breath; dose held, Mar 05 400 mg, Oct 05 2378, May 06 6 73, m CP 350 mg, on phenytoin, Apr 99 35, Jun 99 stopped phenytoin, Jul 99 500 mg, Jul 99 not done; qRT-PCR negative, Jul 06
24
Advani, Sonali D., Sonali D. Advani, Emily Sickbert-Bennett, Elizabeth Dodds Ashley, Andrea Cromer, Yuliya Lokhnygina, Alicia Nelson, et al. "172. Impact of COVID-19 Pandemic on Healthcare-associated Infections (HAIs) in a Large Network of Hospitals." Open Forum Infectious Diseases 8, Supplement_1 (November 1, 2021): S103—S104. http://dx.doi.org/10.1093/ofid/ofab466.172.
Full textAbstract:
Abstract Background The COVID-19 pandemic had a considerable impact on US healthcare systems, straining hospital resources, staff, and operations. Our objective was to evaluate the impact of COVID-19 pandemic on incidence and trends of healthcare-associated infections (HAIs) in a network of hospitals. Methods This was a retrospective review of central-line-associated bloodstream infections (CLABSIs), catheter-associated urinary tract infections (CAUTIs), C. difficile infections (CDI), and ventilator-associated events (VAE) in 51 hospitals from 2018 to 2021. Descriptive statistics were reported as mean hospital-level monthly incidence rates (IR) and compared using Poisson regression GEE models with period as the only covariate. Segmented regression (SR) analysis was performed to estimate changes in monthly IR of CAUTIs, CLABSIs and CDI in the baseline period (01/2018 – 02/2020) and the Pandemic period (03/2020 – 03/2021). SR model was not appropriate for VAE based on the plot. All models were constructed using SAS v.9.4 (SAS Institute, Cary NC). Results Compared to the baseline period, CLABSIs increased significantly by 50% from 0.6 to 0.9/ 1000 catheter days (P< 0. 001). In contrast, no significant changes were identified for CAUTI (P=0.87). Similar trends were seen in SR models for CLABSI and CAUTI (Figures 1, 2 and Table 1). While overall CDIs decreased significantly from 3.5 to 2.5/10,000 patient days in the pandemic period (P< 0.001), SR model showed increasing pandemic trend change (Figure 3). VAEs increased > 700% from 6.9 to 59.7/1000 ventilator days (P=0.15), but displayed considerable variation during the pandemic period (Figure 4). Compared to baseline period, there was a significant increase in central line days (647 vs 677, P=0.02), ventilator days (156 vs 215, P< 0.001), but no change in urinary catheter days (675 vs 686, P=0.32) during the pandemic period. Figure 1: Segmented Regression model showing baseline and pandemic period trends of CLABSI Figure 2: Segmented Regression model showing baseline and pandemic period trends of CAUTI Figure 3: Segmented Regression model showing baseline and pandemic period trends of C. difficile (HO-CDI) infections Conclusion The COVID-19 pandemic was associated with substantial increases in CLABSIs and VAEs, no change in CAUTIs, and an increasing trend in CDI incidence. These variations in trends of different HAIs are likely due, in part, to unique characteristics of the underlying infection, resource shortages, staffing concerns, increased device use, changes in testing practices, and the limitations of surveillance definitions. Figure 4: Trend of Ventilator-Associated Events (VAE) in the baseline and pandemic period (Segmented Regression model not appropriate) Disclosures Sonali D. Advani, MBBS, MPH, Nothing to disclose David J. Weber, MD, MPH, Merck (Individual(s) Involved: Self): Consultant; PDI (Individual(s) Involved: Self): Consultant; Pfizer (Individual(s) Involved: Self): Consultant; Sanofi (Individual(s) Involved: Self): Consultant; UVinnovators (Individual(s) Involved: Self): Consultant
25
Pérez, J. F., J. Balcells, J. A. Guada, and C. Castrillo. "Rumen microbial production estimated either from urinary purine derivative excretion or from direct measurements of 15N and purine bases as microbial markers: effect of protein source and rumen bacteria isolates." Animal Science 65, no. 2 (October 1997): 225–36. http://dx.doi.org/10.1017/s1357729800016532.
Full textAbstract:
AbstractFour ewes fitted with ruminal and duodenal T-piece cannulae were each given six diets in a 6 × 4 factorial design. Diets or experimental treatments consisted of two ratios of forage: concentrate (700:150 (LC) and 400: 600 (HO). Forage was ammonia-treated straw and the concentrate was formulated with barley supplemented with one of three protein sources: sunflower meal, soya-bean meal or fish meal. Duodenal flows ofdigesta were estimated by the dual-phase technique using Co-EDTA and Yb acetate as liquid and solid markers. Microbial nitrogen (N) was estimated from the digesta flow of purine bases and 15N enrichment using as reference samples, bacterial isolates from the liquid (LAB) or solid (SAB) phase of rumen digesta.Duodenal flow of purine bases (mmol/day) was lower on LC (12·9) than HC (17·7) diets but in both treatments it was depressed by fish meal (12·3) compared with either soya-bean (17·3) or sunflower meal (16·3) as supplements (s.e. 1·13). Urinary excretion of purine derivatives showed a similar trend, 8·6 v. III mmol/day in LC and HC respectively and 8·8 v. 10·4 and 10·5 mmol/day in fish meal, soya-bean and sunflower meal diets (s.e. 0·56), respectively. Variation in excretion of urinary purine derivatives was mainly associated with digestible organic matter intake with an average ratio of 1·7 (s.e. 0·11) mmol per 100 g digestible organic matter intake. Irrespective of the microbial marker used, microbial yield was higher in animals offered HC than in those offered LC and with soya-bean or sunflower meal compared with fish meal supplemented diets. The microbial purine bases/N (mmol/g) ratio varied between LAB (1·99, s.e. 0·092) and SAB (1·69, s.e. 0·071) isolates leading to different estimates of microbial-N yield (g) from duodenal purine bases (7·76 (s.e. 2·84) v. 9·13 (s.e. 3·24)), urinary excretion of allantoin (5·57 (s.e. 2·0) v. 6·57 (s.e. 2·03)) or total purine derivatives (6·43 (s.e. 2·39) v. 7·56 (s.e. 2·77)). Urinary excretion of allantoin or total purine derivatives provided consistently lower estimates of duodenal microbial-N than duodenal purine bases or 15N, although it closely reflected the pattern observed in direct measurements.
26
Kolusu, S. R., J. H. Marsham, J. Mulcahy, B. Johnson, C. Dunning, M. Bush, and D. V. Spracklen. "Impacts of Amazonia biomass burning aerosols assessed from short-range weather forecasts." Atmospheric Chemistry and Physics Discussions 15, no. 13 (July 10, 2015): 18883–919. http://dx.doi.org/10.5194/acpd-15-18883-2015.
Full textAbstract:
Abstract. The direct radiative impacts of Biomass Burning Aerosols (BBA) on meteorology are investigated using short-range forecasts from the Met Office Unified Model (MetUM) over South America during the South American Biomass Burning Analysis (SAMBBA). The impacts are evaluated using a set of three simulations: (i) no aerosols, (ii) with monthly mean aerosol climatologies and (iii) with prognostic aerosols modelled using the Coupled Large-scale Aerosol Simulator for Studies in Climate (CLASSIC) scheme. Comparison with observations show that the prognostic CLASSIC scheme provides the best representation of BBA. The impacts of BBA are quantified over central and southern Amazonia from the first and second day of two day forecasts during 14 September–03 October 2012. On average, during the first day of the forecast, including prognostic BBA reduces the clear-sky net radiation at the surface by 15 ± 1 W m−2, and reduces net TOA radiation by 8 ± 1 W m−2, with a direct atmospheric warming of 7 ± 1 W m−2. BBA-induced reductions in all-sky radiation are smaller in magnitude: 9.0 ± 1 W m−2 at the surface and 4.0 ± 1 W m−2 at TOA. In this modelling study the BBA therefore exert an overall cooling influence on the Earth–atmosphere system, although some levels of the atmosphere are directly warmed by the absorption of solar radiation. Due to the reduction of net radiative flux at the surface the mean 2 m air temperature is reduced by around 0.1 ± 0.02 °C. The BBA also cools the boundary layer (BL) but warms air above by around 0.2 °C due to the absorption of shortwave radiation. The overall impact is to reduce the BL depth by around 19 ± 8 m. These differences in heating lead to a more anticyclonic circulation at 700 hPa, with winds changing by around 0.6 m s−1. Inclusion of BBA in the MetUM significantly improves forecasts of temperature and relative humidity, but effects were small compared with model error and differences between effects from climatological and prognostic BBA were not significant. Locally, on a 150 km scale, changes in precipitation reach around 4 mm day−1 due to changes in the location of convection. Over Amazonia, including BBA in the simulation led to fewer rain events that were more intense. This change may be linked to the BBA changing the vertical profile of stability in the lower atmosphere. The localised changes in rainfall tend to average out to give a 5 % (0.06 mm day−1) decrease in total precipitation over the Amazonian region (except on day 2 with prognostic BBA). The change in water budget from BBA is, however, dominated by decreased evapotranspiration from the reduced net surface fluxes (0.2 to 0.3 mm day−1), since this term is larger than the corresponding changes in precipitation and water vapour convergence.
27
Modak, Sanat Vibhas, Joseph Valle, David G. Kwabi, and Jeff Sakamoto. "(Digital Presentation) Evaluating Stability and Performance of Nasicon Membranes for Crossover Mitigation in Aqueous Redox-Flow Batteries." ECS Meeting Abstracts MA2022-01, no. 48 (July 7, 2022): 1997. http://dx.doi.org/10.1149/ma2022-01481997mtgabs.
Full textAbstract:
Most polymer-based membranes that are used in prototypical aqueous redox-flow batteries (RFBs) do not adequately prevent crossover of small-molecule reactants, causing high rates of capacity fade. Ceramic superionic conductor membranes are an attractive alternative due to their superior abilities to mitigate crossover;1 they can thus enable the deployment of electrolytes containing earth-abundant, small-molecule reactants.2 3 We test the performance and stability of a von Alpen sodium superionic conductor Na3.1Zr1.55Si2.3P0.7O11 (NaSICON) as an RFB membrane by examining its resistance, permeability and interfacial morphology as a function of electrolyte composition and temperature. The resistance of NaSICON is stable for several weeks while immersed in neutral to strongly alkaline ([OH-] = 3 M) aqueous electrolytes, and its permeability to polysulfide-based and permanganate-based small-molecule RFB reactants is negligible compared to that of Nafion. The glassy phase of the NaSICON microstructure at the membrane-electrolyte interface undergoes small amounts of etching while in contact with aqueous electrolytes containing sodium ions, which becomes more extensive when potassium ions are present in the electrolyte, leading in certain instances to complete disintegration of the membrane. We report a ferrocyanide-permanganate flow cell at a pH of 14.5 with a ~ 700 μm-thin NaSICON membrane supporting weeks of cycling with apparently negligible reactant crossover and very low capacity fade (< 0.04 %/day). Area-specific resistance of NaSICON falls dramatically with increasing temperature and decreasing membrane thickness, and a membrane that is 100 µm thick or thinner can enable power densities at above-ambient temperatures that are comparable to power densities of polymer membrane-containing flow cells. (1) Yu, X.; Gross, M. M.; Wang, S.; Manthiram, A. Aqueous Electrochemical Energy Storage with a Mediator-Ion Solid Electrolyte. Advanced Energy Materials 2017, 7 (11), 1602454, https://doi.org/10.1002/aenm.201602454. DOI: https://doi.org/10.1002/aenm.201602454 (acccessed 2021/03/12). (2) Wei, X.; Xia, G.-G.; Kirby, B.; Thomsen, E.; Li, B.; Nie, Z.; Graff, G. G.; Liu, J.; Sprenkle, V.; Wang, W. An aqueous redox flow battery based on neutral alkali metal ferri/ferrocyanide and polysulfide electrolytes. J. Electrochem. Soc. 2016, 163 (1), A5150-A5153. DOI: 10.1149/2.0221601jes]. (3) Colli, A. N.; Peljo, P.; Girault, H. H. High energy density MnO4-/MnO42- redox couple for alkaline redox flow batteries. Chem Commun (Camb) 2016. DOI: 10.1039/c6cc08070g.
28
Patel, K. V., J. Segal, S. Sebastian, S. Subramanian, T. Conley, H. Gonzalez, A. Kent, et al. "DOP35 Ambulatory care management of 70 patients with Acute Severe Ulcerative Colitis in comparison to 700 inpatients: Insights from a multicentre UK cohort study." Journal of Crohn's and Colitis 15, Supplement_1 (May 1, 2021): S073—S074. http://dx.doi.org/10.1093/ecco-jcc/jjab073.074.
Full textAbstract:
Abstract Background Acute severe ulcerative colitis (ASUC) traditionally requires inpatient hospital management for intravenous therapies and/or colectomy. Patients with ASUC can deteriorate rapidly and hence require close monitoring of vital signs correlated with clinical, biochemical and radiological investigations. Traditionally, patients are admitted to hospital to facilitate endoscopic assessment, exclude concomitant infective complications, monitor response to first-line corticosteroid treatment and determine the need for and timing of rescue therapy and/or colectomy. Ambulatory care pathways, which utilise outpatient monitoring and drug delivery, have been shown to deliver safe and effective treatment for conditions which have historically mandated hospitalisation e.g. pulmonary embolus. To date there are a paucity of data regarding the use of ambulatory pathways in ASUC cohorts. We used data from PROTECT, a UK multicentre observational COVID-19 i (IBD) study, to report the extent, safety and effectiveness of ASUC ambulatory pathways. Methods Adults (≥ 18 years old) meeting Truelove and Witts criteria between 01/01/2019- 01/06/2019 and 01/03/2020–30/06/2020 were recruited to PROTECT (Figure 1). We utilised demographic, disease phenotype, treatment outcomes and 3-month follow-up data. Primary outcome was rate of rescue therapy and/or colectomy. Secondary outcomes included corticosteroid response, response to rescue therapy, colectomy, mortality and hospital readmission within 3-months. We compared outcomes in 3 cohorts: i) patients treated entirely in inpatient setting; ambulatory patients subdivided into ii) patients hospitalised and subsequently discharged to ambulatory care; iii) patients managed as ambulatory from diagnosis . Results 38%(23/60) participating hospitals used ambulatory pathways. Of 770 eligible patients, 700(91%) patients received entirely inpatient care, 55(7%) patients were discharged to ambulatory pathways and 15(2%) patients were managed as ambulatory from diagnosis. The rate of rescue therapy and/or colectomy (49%[339/696] vs 41%[22/54] vs 67%[10/15], respectively, p=0.18) (figure 2) and secondary outcomes were similar among all three cohorts. After 3-months follow up from the index ASUC diagnosis there was no significant difference in either rate of UC flare, readmission to hospital with UC flare or colectomy between the cohorts. Conclusion In the largest description of ambulatory ASUC care to date, we report an emerging practice which challenges treatment paradigms. Our data suggest ambulatory ASUC treatment may be safe and effective in selected patients but further studies exploring clinical and cost effectiveness as well as patient and physician acceptability are needed.
29
Allen, Matthew B., Ariela R. Orkaby, Samuel Justice, Daniel E. Hall, Frances Y. Hu, Zara Cooper, Rachelle E. Bernacki, and Angela M. Bader. "Frailty and Outcomes Following Cardiopulmonary Resuscitation for Perioperative Cardiac Arrest." JAMA Network Open 6, no. 7 (July 3, 2023): e2321465. http://dx.doi.org/10.1001/jamanetworkopen.2023.21465.
Full textAbstract:
ImportanceFrailty is associated with mortality following surgery and cardiopulmonary resuscitation (CPR) for in-hospital cardiac arrest. Despite the growing focus on frailty as a basis for preoperative risk stratification and concern that CPR in patients with frailty may border on futility, the association between frailty and outcomes following perioperative CPR is unknown.ObjectiveTo determine the association between frailty and outcomes following perioperative CPR.Design, Setting, and ParticipantsThis longitudinal cohort study of patients used the American College of Surgeons National Surgical Quality Improvement Program, including more than 700 participating hospitals in the US, from January 1, 2015, through December 31, 2020. Follow-up duration was 30 days. Patients 50 years or older undergoing noncardiac surgery who received CPR on postoperative day 0 were included; patients were excluded if data required to determine frailty, establish outcome, or perform multivariable analyses were missing. Data were analyzed from September 1, 2022, through January 30, 2023.ExposuresFrailty defined as Risk Analysis Index (RAI) of 40 or greater vs less than 40.Outcomes and MeasuresThirty-day mortality and nonhome discharge.ResultsAmong the 3149 patients included in the analysis, the median age was 71 (IQR, 63-79) years, 1709 (55.9%) were men, and 2117 (69.2%) were White. Mean (SD) RAI was 37.73 (6.18), and 792 patients (25.9%) had an RAI of 40 or greater, of whom 534 (67.4%) died within 30 days of surgery. Multivariable logistic regression adjusting for race, American Society of Anesthesiologists physical status, sepsis, and emergency surgery demonstrated a positive association between frailty and mortality (adjusted odds ratio [AOR], 1.35 [95% CI, 1.11-1.65]; P = .003). Spline regression analysis demonstrated steadily increasing probability of mortality and nonhome discharge with increasing RAI above 37 and 36, respectively. Association between frailty and mortality following CPR varied by procedure urgency (AOR for nonemergent procedures, 1.55 [95% CI, 1.23-1.97]; AOR for emergent procedures, 0.97 [95% CI, 0.68-1.37]; P = .03 for interaction). An RAI of 40 or greater was associated with increased odds of nonhome discharge compared with an RAI of less than 40 (AOR, 1.85 [95% CI, 1.31-2.62]; P &lt; .001).Conclusions and RelevanceThe findings of this cohort study suggest that although roughly 1 in 3 patients with an RAI of 40 or greater survived at least 30 days following perioperative CPR, higher frailty burden was associated with increased mortality and greater risk of nonhome discharge among survivors. Identifying patients who are undergoing surgery and have frailty may inform primary prevention strategies, guide shared decision-making regarding perioperative CPR, and promote goal-concordant surgical care.
30
Koltai, Gábor, Zsolt Giczi, Viliam Nagy, Gábor Illés, and Kálmán Rajkai. "The effect of the Danube diversion on the soil moisture conditions in Csallóköz and Szigetköz." Scientia et Securitas 2, no. 4 (March 26, 2022): 468–75. http://dx.doi.org/10.1556/112.2021.00063.
Full textAbstract:
Summary. Following the commissioning of the Gabčíkovo (Bős) hydroelectric power plant in 1992, a monitoring program was launched to assess the agricultural and forestry consequences of the diversion of the Danube into a newly built derivation channel in the Žitný ostrov (Csallóköz) and Szigetköz areas. Prior to the Danube diversion, groundwater played a significant role in the water supply of plants, therefore it is of primary importance to monitor the changes in groundwater levels and soil moisture. Correlation between the groundwater depth and soil moisture time series taken at four measurement points of Szigetköz (T-03, T-04, T-09, T-16) between 1995 and 2012 was analysed. Average and extreme water levels (quartiles 1 and 4) were examined for the 18-year time series, in which 2nd and 3rd quartiles of the groundwater levels were treated together as characteristic water level. It was found that groundwater significantly correlated with soil moisture storage below the rooting zone of field crops. Összefoglalás. A Gabčíkovo (Bős) vízerőművet 1992-ben helyezték üzembe. A dunacsúnyi duzzasztó vize a bősi erőművön átfolyva a Szlovákiában épített vízlevezető csatornából 40 km után tért vissza a korábbi Duna főmederbe. A régi Duna főmederbe emiatt az elterelt szakaszon a korábbi vízmennyiség ötöde került. Minthogy mind a szlovákiai, mind a magyarországi mezőgazdasági és erdőterületek vízellátásában a talajvíz és a dunai árhullámok jelentős szerepet játszottak, 1995-től a Duna-elterelés hatásának felmérésére talajvízszint és talajnedvesség monitoring program indult a Csallóközben és a Szigetközben. A szlovák megfigyelések publikált anyagainak megállapításait és a Szigetközből két szántóföld, egy kaszálórét és egy nyárfaültetvény 1995 és 2012 közötti mérési adatait dolgoztuk fel. A talajvízmélység és a 10 cm-es talajrétegek mért térfogatszázalékos (v.%) nedvességtartalmából számított talajvízkészletek közötti korrelációt számítottuk. A 18 éves idősoron külön vizsgáltuk a jellemző, illetve a szélsőséges vízszintek (1. és 4. kvartilisek) hatását. A jellemző vízszintek hatásának vizsgálatához a talajvízszint értékek 2. és 3. kvartilisét egyben kezeltük. Megállapítottuk, hogy szignifikáns, ill. közel szignifikáns összefüggés csupán az átlagosnál a talajfelszínhez közelebbi (Q1) talajvízmélység esetén volt kimutatható mind a mély (T-03), mind a sekély talajrétegű (T-09) szántóföld 210–300 cm-es, illetve 120–140 cm-es talajszintjében. Vagyis a szántóföldi kultúrák számára az átlagos talajvízmélység nem jelentett vízpótlást. A régi Duna főmederhez közeli kaszálóréten (T-04) a talajvízmélység helyett a dunaremetei medervízszint adatok és a talajnedvességkészlet között még a 140 cm-es mélységben található kavicsos alapkőzet fölötti 20 cm-es talajrétegben sem volt jelentős kapcsolat. A mély talajrétegű (300 cm) erdészeti mérőhely (T-16) talajvízmélység és talajnedvességkészlet korrelációja csupán a 210–300 cm-es talajréteg esetében volt közel szignifikáns. A nyárültetvények fejlődéséhez szükséges éves 700–900 mm vízigény biztosítására emiatt a régi Duna főmederbe engedett többletvízre lenne szükség. A szántóföldi kultúrák terméshozama is elsősorban az adott év csapadékmennyisége és eloszlása szerint alakul. Amennyiben az időjárási feltételek kedvezőtlenek, megoldásként öntözni szükséges. Beszámoltunk továbbá arról, hogy két éve négy mérőhely üzemel, ami a naponta óránként mért 6 órás átlag talajnedvesség-adatokat gyűjti. A folyamatos talajnedvesség-adatgyűjtés célja az időjárás, a növényi vízfelhasználás és a talajvízből történő nedvesítés nyomon követése és a talajvízforgalom-modell leírásának a kontrollja. A közeljövő feladata az évente 12-14 alkalommal az ezeken a mérőhelyeken is gyűjtött kapacitívszondás és a folyamatos nedvességmérési eredmények megfeleltetése, minthogy a bemutatott közel azonos példa mellett több helyen és mélységben időben párhuzamos módon változik ugyan a kétféle érték, azonban akár több, mint 5 v.% különbséggel.
31
Klickstein, Lloyd, Amy Flynt, Dawn Edgerton, Kiran Dole, and Kevin Nguyen. "RF28 | PSUN198 The Dramatic Fat Mass Loss Caused by Bimagrumab is Similar in Diabetic and Non-diabetic Patients." Journal of the Endocrine Society 6, Supplement_1 (November 1, 2022): A37—A38. http://dx.doi.org/10.1210/jendso/bvac150.077.
Full textAbstract:
Abstract Bimagrumab is a fully human, ligand-blocking antibody to activin receptors type IIA and type IIB that in obese diabetic patients has been shown to improve body composition dramatically. After 48 weeks of treatment (N=75, allocated 1: 1, bimagrumab intravenously (iv) 10 mg/kg/month: placebo), in the bimagrumab group total body fat mass decreased by 20.5% while at the same time, lean mass increased by 3.6%, both assessed by dual X-ray absorptiometry (DXA). At 24 weeks, fat mass loss was 16.5% in those treated with bimagrumab, while there was little effect on fat or lean mass in the placebo group at either timepoint. In a subset of patients who underwent magnetic resonance imaging, the fat loss effect was greatest for hepatic fat, with a 52% reduction from baseline to week 48, and for abdominal visceral fat, where a 34% decrease was observed over the same interval (Heymsfield SB et al. JAMA Open 2021;4: e2033457). Most drugs for obesity are less effective in diabetics, so to evaluate the efficacy of bimagrumab on fat mass in non-diabetics, we undertook a pooled analysis of patient-level data from 6 clinical studies of bimagrumab previously conducted to assess muscle anabolic activity and/or clinical safety. Criteria for study selection included at least 24 weeks of therapeutic drug exposure, DXA performed at baseline and at least 2 additional time points. Studies that recruited patients with known, underlying primary diseases of adipose tissue or muscle were excluded. Of the 568 subjects in these 6 studies, 7 were identified as diabetic and excluded, leaving 561 subjects in 4 dose groups including placebo (N=204), 70 mg iv monthly (N=43), 210 mg iv monthly (N=75), or a top dose group comprising 700 mg iv once monthly or 10 mg/kg iv once monthly or 30 mg/kg iv q8w x 2 (total N=239). A dose- and time-dependent effect of bimagrumab on fat loss was observed and at the 24 week time point, the top dose group lost 14.6% (LS mean (95% CI) 13.2% - 16.0%) of total body fat mass, while the placebo group increased their fat mass by 2.4% (0.9% - 3.8%). Approximately 41% of the subjects in this pooled analysis were overweight or obese, which is a potential limitation of this study since all subjects in the diabetes study were overweight or obese, however this likely does not affect the conclusion since no effect of baseline BMI on % initial body fat lost at week 24 was seen. Thus, unlike most other drugs for obesity, the efficacy of bimagrumab is very similar in both diabetic patients and in non-diabetic patients. Presentation: Sunday, June 12, 2022 12:30 p.m. - 2:30 p.m., Monday, June 13, 2022 12:58 p.m. - 1:03 p.m.
32
Mufarrih, AM, Moh Nasir Hariyanto, and Nanang Qosim. "Analisa Kekasaran Permukaan Titanium Grade 2 pada Proses Frais." Jurnal Pendidikan Teknik Mesin Undiksha 8, no. 2 (August 1, 2020): 53. http://dx.doi.org/10.23887/jptm.v8i2.27766.
Full textAbstract:
Titanium Grade 2 termasuk jenis bahan yang sering dipergunakan di industri, utamanya pada bahan untuk implan biomedis. Titanium Grade 2 mempunyai sifat perbandingan kekakuan terhadap berat yang baik, tahan terhadap korosi dan memiliki sifat biokompatibel yang baik di dalam tubuh. Namun memiliki konduktifitas panas yang rendah, sehingga perlu memilih perameter pemesinan yang tepat untuk menghasilkan nilai kekasaran permukaan yang baik. Penelitian ini bertujuan untuk mengetahui karakteristik Titanium Grade 2 yaitu kekasaran permukaan hasil pemesinan frais. Desain penelitian menggunakan metode Taguchi L9, dengan 2 faktor dan 3 level. Parameter pemesinan yang digunakan ialah putaran spindel 500; 700; 900 rpm dan kecepatan pemakanan 25; 50; 75 mm/menit. Variabel respon yang diteliti ialah kekasaran permukaan. Proses frais dilakukan menggunakan Mesin CNC Dahlih. Kekasaran permukaan diukur menggunakan Mitutoyo surface roughess tester. Analisis data menggunakan analisis ANOVA. Hasil penelitian menunjukan bahwa ada pengaruh variasi parameter pemesinan terhadap respon kekasaran permukaan. Variabel putaran spindel mempunyai p-value sebesar 0,039 dan variabel gerak makan memiliki p-value sebesar 0,025. Hal ini menunjukkan bahwa kedua variabel bebas tersebut memiliki pengaruh yang signifikan terhadap respon kekasaran permukaan. Kekasaran permukaan terendah dapat dicapai dengan pengaturan putaran spindel sebesar 700 rpm dan kecepatan pemakanan sebesar 25 mm/menit. Kata kunci: titanium grade 2, kekasaran permukaan, frais, anova Daftar RujukanBagno, A., & Di Bello, C. (2004). Surface treatments and roughness properties of Ti-based biomaterials. Journal of Materials Science: Materials in Medicine. https://doi.org/10.1023/B:JMSM.0000042679.28493.7fBruce, 2011. (2013). Analisis Kekasaran Permukaan Dan Getaran Pada Pemesinan Bubut Menggunakan Pahat Putar Modular (Modular Rotary Tools) Untuk Material Titanium 6Al-4V Eli. Journal of Chemical Information and Modeling. https://doi.org/10.1017/CBO9781107415324.004Davim, J. P. (2011). Machining of hard materials. Machining of Hard Materials. https://doi.org/10.1007/978-1-84996-450-0Ganguli, S., & Kapoor, S. G. (2016). Improving the performance of milling of titanium alloys using the atomization-based cutting fluid application system. Journal of Manufacturing Processes. https://doi.org/10.1016/j.jmapro.2016.05.011Karkalos, N. E., Galanis, N. I., & Markopoulos, A. P. (2016). Surface roughness prediction for the milling of Ti-6Al-4V ELI alloy with the use of statistical and soft computing techniques. Measurement: Journal of the International Measurement Confederation. https://doi.org/10.1016/j.measurement.2016.04.039Kiswanto, G., Mandala, A., Azmi, M., & Ko, T. J. (2020). The effects of cutting parameters to the surface roughness in high speed cutting of micro-milling titanium alloy ti-6al-4v. Key Engineering Materials, 846 KEM, 133–138. https://doi.org/10.4028/www.scientific.net/KEM.846.133Mufarrih, A., Istiqlaliyah, H., & Ilha, M. M. (2019). Optimization of Roundness, MRR and Surface Roughness on Turning Process using Taguchi-GRA. In Journal of Physics: Conference Series. https://doi.org/10.1088/1742-6596/1179/1/012099Nithyanandam, J., Das, S. L., & Palanikumar, K. (2015). Inluence of Cutting Parameters in Machining of Titanium Alloy. Indian Journal of Science and Technology, 8(8), 556–562. https://doi.org/10.17485/ijst/2015/v8i/71291Oshida, Y. (2012). Bioscience and Bioengineering of Titanium Materials: Second Edition. Bioscience and Bioengineering of Titanium Materials: Second Edition. https://doi.org/10.1016/C2011-0-07805-5Setyowidodo, I., Sutanto, S., Mufarrih, A., & Sholehah, I. M. (2020). Exhaust temperature and peltier element optimization of thermoelectric generator output. In IOP Conference Series: Materials Science and Engineering. https://doi.org/10.1088/1757-899X/850/1/012007Shucai, Y., Chunsheng, H., & Minli, Z. (2019). A prediction model for titanium alloy surface roughness when milling with micro-textured ball-end cutters at different workpiece inclination angles. International Journal of Advanced Manufacturing Technology. https://doi.org/10.1007/s00170-018-2852-6Soepangkat, B. O. P., Pramujati, B., Effendi, M. K., Norcahyo, R., & Mufarrih, A. M. (2019). Multi-objective Optimization in Drilling Kevlar Fiber Reinforced Polymer Using Grey Fuzzy Analysis and Backpropagation Neural Network–Genetic Algorithm (BPNN–GA) Approaches. International Journal of Precision Engineering and Manufacturing. https://doi.org/10.1007/s12541-019-00017-zTapiero, H., Townsend, D. M., & Tew, K. D. (2003). Trace elements in human physiology and pathology. Copper. Biomedicine and Pharmacotherapy. https://doi.org/10.1016/S0753-3322(03)00012-XThepsonthi, T., & Özel, T. (2012). Multi-objective process optimization for micro-end milling of Ti-6Al-4V titanium alloy. International Journal of Advanced Manufacturing Technology. https://doi.org/10.1007/s00170-012-3980-zWennerberg, A., & Albrektsson, T. (2009). Effects of titanium surface topography on bone integration: A systematic review. Clinical Oral Implants Research. https://doi.org/10.1111/j.1600-0501.2009.01775.x
33
Fernández-Rivera, S., A. Midou, and H. Marichatou. "Effect of food allowance on diet selectivity and intake of pearl millet (Pennisetum glaucum) stover leaves by sheep." Animal Production 58, no. 2 (April 1994): 249–56. http://dx.doi.org/10.1017/s1357729800042569.
Full textAbstract:
AbstractThe influence of food allowance or level of food excess on diet selectivity and intake by sheep given pearl millet stover leaves, and the potential feeding value of the food leftovers (not eaten) (L) were studied. Animals were given food at four levels of L (100, 300, 500 and 700 g dry matter (DM) per day). All sheep received different food allowances (A, g DM per day) and had different L/A and A/M (g DM per kg M) ratios. An additional treatment consisted of feeding the leftovers from the two highest levels of food excess to six rams to have 300 g DM of L per day. A diet supplement was given to provide sufficient rumen degradable protein and sulphur to sustain microbial activity. Variances of organic matter (OM) digestibility (OMD, g/kg) and intake (g/kg M0·75) of both DM (DMI) and digestible OM (DOMI) of the original millet leaves were analysed using L, L/A, A/M and A/M0·75as independent variables. Variation accounted for was highest when OMD was analysed as a function of L/A (R2= 0·34) and when DMI was analysed as a function of A/M (R2= 0·79) or A/M0·75(R2= 0·80). The response in OMD to varying L/A was best described by the equation OMD = 457 (s.e. 16) + 157 (s.e. 48) L/A. As L/A or A/M increased, L had a lower concentration of acid-detergent fibre and a higher in sacco OM disappearance. As A/M increased, DOMI and L/A increased following a diminishing return pattern. However, when A/M fell below 31·1 (s.e. 0·9) g DM per kg M, DOMI decreased linearly. No differences (P> 0·33) were observed for OMD between the original food (505 (s.e. 8) g/kg) and the re-fed leftovers (489 (s.e. 15) g/kg), but DOMI was lower with the latter (22•4 (s.e. 0·4) v. 20·3 (s.e. 0·8) g/kg M0˙75,P< 0·03). Results suggest that DOMI of millet stover should be determined at L/A much higher than the traditionally recommended (0·15), and support the hypothesis that farmers could benefit from feeding millet stover at high allowances to animals of high economic value and give the leftovers to less valuable or less selective stock.
34
Liu, L. W., M. Syrzycka, P. Janiszewski, L. Kemps, and B. Degeronimo. "A179 CANADIAN INVOLVEMENT IN THE EVALUATION OF NOVEL THERAPY FOR DIABETIC GASTROPARESIS: OVERVIEW OF PLEDGE TRIALS." Journal of the Canadian Association of Gastroenterology 3, Supplement_1 (February 2020): 45–47. http://dx.doi.org/10.1093/jcag/gwz047.178.
Full textAbstract:
Abstract Background Diabetic gastroparesis(DG) is a serious, chronic complication of type 1 or 2 diabetes mellitus(DM) presenting with a delay in gastric emptying(GE). An estimated 3 million Canadians have been diagnosed with DM; up to 5% of these patients may develop DG. DG can result in poor glycemic control, recurrent nausea and vomiting, often resulting in hospitalization. To date, no effective treatments are available. A phase 2 study showed that relamorelin (RLM), a synthetic ghrelin agonist, was safe and effective in treating DG. Investigators across Canada are participating in a set of phase 3 international trials of RLM in the treatment of DG. Aims To report the Canadian involvement in the international effort to evaluate the safety and efficacy of RLM in the treatment of DG. PLEDGE is a set of 5 trials: two identical 12-week studies, a 46-week extension study, a 52-week exposure study, and an open-label extension study. Collectively, the data from these studies will help to evaluate the safety and efficacy of RLM, a novel treatment for Canadian patients living with DG. Methods Four global, multicenter, randomized, double-blind, placebo-controlled, parallel-group studies compare the efficacy of RLM with placebo in participants with DG using composite endpoints of nausea, abdominal pain, postprandial fullness, bloating. Participants are randomized to RLM 10μg or placebo subcutaneously (SC) twice daily groups. The open-label continuation of treatment will follow participants until RLM becomes commercially available to provide long-term safety information to support the safe use of RLM as a chronic treatment of DG. As seen in Figure 1, participants from the two 12-week studies will rollover into the third study that will continue for 46 weeks. The fourth study will enroll participants that were not randomized in the first two studies because their symptoms were less severe and will also accept new participants. Participants will be randomized 2:1 to RLM 10μg or placebo SC twice daily groups. Participants from the third and fourth studies have the option to enroll in the open-label study. Results Target enrollment is approx. 1800 participants for the 4 global, multicenter, randomized, double-blind, placebo-controlled, parallel-group studies and 1000 participants for the open label study. 700 sites are expected to participate globally; 15 Canadian sites in 6 provinces are participating. Conclusions Canadian centers are actively involved in the PLEDGE trials to help determine the efficacy and safety of RLM, a potential new treatment for DG. This publication increases awareness of the Canadian gastroenterology community, providing an option to refer interested patients to PLEDGE study centers. PLEDGE Studies (NCT03285308, NCT03426345, NCT03420781, NCT03383146, NCT03786380): Placebo-controlled, randomized RLM-MD-01/02/03/04 and open-label study 3071-305-020 to study the safety and efficacy of relamorelin for the treatment of diabetic gastroparesis Funding Agencies None
35
Minser, Ozar P., Maksim M. Potiazhenko, and Ganna V. Nevoit. "EVALUATION OF THE HUMAN BIOELECTROMAGNETIC FIELD IN MEDICINE: THE DEVELOPMENT OF METHODOLOGY AND PROSPECTS ARE AT THE PRESENT SCIENTIFIC STAGE." Wiadomości Lekarskie 72, no. 5 (2019): 1117–21. http://dx.doi.org/10.36740/wlek201905231.
Full textAbstract:
Introduction: The authors focus on the unresolved problem of NCDs and on the relevance of further scientific research in accordance with the current physics-biological level of knowledge about the structure and functioning of the human body. In the course, emphasis is placed on the need for further study of methods for assessing the bioelectromagnetic field of the human body as a potential “tool” for a possible solution of the NCD problem in the framework of system medicine. The aim is to assess the level of development of the methodology and substantiate the scientific feasibility of further exploring the possibilities of the clinical application of these methods for assessing the bioelectromagnetic field of the human body in the algorithms for examining and managing patients with NCDs to study valeological status and objective monitoring of physical phenomena in the clinic of internal diseases. Materials and methods: The analysis of the literature data was carried out in the course of a search study of methods for the rapid assessment of valeological status as a fragment of the initiative research project “Development of algorithms and technology for introducing a healthy lifestyle in patients with non-communicable diseases based on the study of psycho-emotional status” (State registration No. 0116U007798, UDC 613:616-052:159.942:616-03). Review: The gnoseological aspect of the development of the methodology for assessing the bioelectric and biomagnetic fields of the human body is described in the article. The conditional time stages of the methodology are highlighted and characterized in it. It was proposed to distinguish between periods: 1) cumulative (XIII-XVIII centuries), 2) cumulative-dynamic (XII-XX centuries), 3) modern (XXI century) 4) modern (prospective). Questions of the feasibility of further research assessing the bioelectromagnetic field of the human body are discussed. Conclusions: 1. The above gnoseological aspect of the 700-year-old methodology for studying the bioelectromagnetic field of a human body demonstrates a staged evolution of its development, the presence of a significant amount of cumulated scientific information, which requires rethinking as part of system medicine. This convinces us of the existence of a tendency of inevitable approaching the final stage of knowledge of the human bioelectromagnetic field with the widespread introduction of these techniques into the practical public health of the world. 2. The accumulated layer of scientific knowledge about the bioelectromagnetic component of the human body requires integration into fundamental medicine, transformation of the modern paradigm by creating a bioelectromagnetic-chemical concept of the exchange of matter and energy in the human body. 3. Further research on the assessment of the bioelectromagnetic field is relevant and can contribute to solving the NCD problem both at a fundamental level within the framework of system medicine and by optimizing the diagnostic assessment in patient management algorithms during diagnosis, treatment, primary and secondary prevention.
36
Stein, Anthony Selwyn, M. O’Donnell, P. Parker, R. Spielberger, A. Nademanee, R. Bhatia, D. S. Snyder, et al. "Analysis of Long Term Outcome in Autologous Stem Cell Transplant (ASCT) for Acute Myelogenous Leukemia (AML) in First Remission (CR1) - a 15 Year Experience." Blood 104, no. 11 (November 16, 2004): 1870. http://dx.doi.org/10.1182/blood.v104.11.1870.1870.
Full textAbstract:
Abstract Despite improvement in the proportion of patients achieving durable remission with dose intensive consolidation strategies, leukemic relapse still occurs in 40–70% of patients who achieve an initial remission. Studies utilizing ASCT for AML in CR1 have reported relapse free survival between 34–80% based on cytogenetic risk stratification. We report a 15 year experience of ASCT following high dose cytarabine (Ara-C) ± idarubicin (IDA) consolidation in 168 patients (intent to transplant, ITT) in CR1 treated between 3/89 and 6/03. The treatment consisted of a): consolidation with high dose Ara-C ± IDA followed by marrow (M) harvest (n=64) or collection of G-CSF primed stem cells (PSCs) (n=73), b) ASCT using FTBI 12Gy, Etoposide 60mg/kg, Cytoxan 75mg/kg (n=97) or Busulfan targeted to 1st dose AUC 700–900, FTBI 1200Gy and Etoposide 30mg/kg (n=40), and c) IL-2 9x106 IU/m2/24 hrs days 1–4 and IL-2 1.6 x 106 IU/m2/24 hrs days 9–18 beginning at hematologic recovery post ASCT (from 1995-present). Patient characteristics at ITT were median age 40.8 yr. (16.3–60.9); cytogenetics (SWOG criteria) favorable = 42(25%) (including 11 M3 pre 1993), intermediate=70(42%), unfavorable=16(10%), indeterminate and unknown=40(23%); WBC <50,000=125(74%), ≥50,000=41(25%), unknown=2(1%); 147 (88%) received one induction cycle and 12% received two cycles; Ara-C induction dose was 100–200mg/m2 in 49% and 51% received high dose Ara-C induction. Median time from CR1 to consolidation was 27.6 days. Of the 168 patients consolidated, 137 had ASCT. The 100-day non-relapse mortality (NRM) for consolidation+ASCT was 2%. With a median follow up of 9.5 yrs, the 5 yr OS, DFS relapse rate (RR) for 168 ITT patients is 57%, 51%, and 41% respectively. The 5 yr OS, DFS and RR for each cytogenetic category are: favorable 64%, 63%, 29%; intermediate 58%, 50%, 41%; unfavorable 45%, 31%, 67%; and unknown cytogenetics 49%, 48%, 44% respectively. The 5 yr OS, DFS and RR for the 137 transplanted patients were 62%, 59%, and 36%. The 5 year OS and RR for favorable cytogenetics are 69%, 24%; intermediate 62%, 36%; unfavorable 55%, 58%; and unknown 55%, 42% respectively. Prognostic variables analyzed for each outcome in the ITT group were: age, WBC, cytogenetics, Ara-C induction dose, one vs. two inductions and IDA in consolidation. By multivariate analyses the number of inductions was predictive for OS with hazard ratio=2.2 (95%CI:1.2–4.3) p=0.02. No variables were found to be predictive of DFS or relapse. The same variables with the addition of conditioning regimen, IL-2 and M vs. PSCs were analyzed for the 137 transplant patients. By multivariate analysis IL-2 was predictive for OS and DFS and cytogenetics was predictive of relapse. These results demonstrate that the strategy of high dose Ara-C consolidation followed by ASCT can be performed with low NRM. This approach appears to improve the outcome of patients with all cytogenetic risk groups when compared with multiple cycles of high dose Ara-C. The role of post-transplant IL-2 appears to be beneficial and merits further investigation.
37
Bos, R., T. Jansen, S. De Jong, A. Castiglia, and M. Vis. "POS1053 COMPARISON OF BASELINE CHARACTERISTICS BETWEEN PATIENTS CONTINUING OR DISCONTINUING APREMILAST AT TWELVE MONTHS IN THE REWARD STUDY (THE NETHERLANDS)." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 805.1–805. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2081.
Full textAbstract:
Background:Previous analysis of the REWARD study reported that patients with limited joint involvement have a considerable burden of disease1. Recent data suggest that patients with moderately active psoriatic arthritis (PsA) and a limited joint involvement have a high likelihood of achieving treatment goals when treated with apremilast2. According to EULAR recommendations a PDE4 inhibitor may be considered in patients with mild disease and an inadequate response to at least one csDMARD, in whom neither a bDMARD nor a JAK inhibitor is appropriate and the value of apremilast may be found in treating patients with relatively mild disease (oligoarticular)3.Objectives:The objective of this prospective, multicentre, non-interventional study is to describe patient reported outcomes, effectiveness and real-life use of apremilast in patients with PsA. Patients will be followed up for a maximum of 12 months. This interim analysis compared the baseline characteristics and experience on apremilast for two subgroups of patients, those remaining on apremilast versus the ones that discontinued.Methods:In this interim analysis we included patients with data available at cut-off date of 03 November 2020. Patient enrollment and follow up of current subjects is ongoing. Descriptive statistics (n’s and percents for categorical data, means for continuous data) were used to summarize the baseline data by subgroup. Kaplan Meier plots are presented to show patients’ experience on apremilast by subgroup.Results:85 patients were included in the analysis. 30 patients have completed the study, 39 patients have discontinued and 16 are ongoing. At baseline 22 (26%) patients were biologic experienced and 62 (74%) were biologic naïve. Both groups had a comparable disease activity measured with clinical disease activity in psoriatic arthritis (cDAPSA) scores. Biologic experienced patients had a longer disease duration compared to biologic naïve patients (mean 9.7 vs 6.2 years). Inefficacy of previous medication was the main reason for starting apremilast in both subgroups. Overall, 86% (n=69) of patients were still receiving apremilast at month 3, 60% (n=46) at month 6, and 41% (n=26) at month 12 (Figure 1). Drug survival (length of time until discontinuation of apremilast) for biologic naïve patients was 93% at month 3, 73% at month 6 and 58% at month 12. Drug survival of biologic experienced patients was 67%, 20%, and 0% at months 3, 6, and 12, respectively. At baseline mean values of body mass index (BMI), swollen joint count (SJC), tender joint count (TJC), psoriatic arthritis impact of disease (PsAID) were comparable between both groups (Table 1). Reasons for discontinuation were mainly lack of efficacy (49%) and adverse events (44%). In this analysis the nature and frequency of adverse events is in line with the known profile of apremilast.Conclusion:In this interim analysis, patients who were biologic naïve had a better probability to remain on treatment than those who were biologic experienced. Baseline characteristics were similar between the two groups, apart from disease duration that was longer in the biologic experienced group. Best drug survival is achieved when apremilast is prescribed earlier in the PsA treatment course, before biologics and after csDMARDs, as per apremilast EU label.References:[1]Jansen TL, et al. Ann Rheum Dis. 2019;78:913 [abstract FRI0442][2]Mease PJ, et al. Arthritis Care Res 2020 72 6 814–821[3]Gossec L, et al. Ann Rheum Dis 2020;79:700–712Disclosure of Interests:Reinhard Bos Consultant of: AbbVie BV, Genzyme Europe, Janssen-Cilag, Novartis, Pfizer, Grant/research support from: Galapagos, Tim Jansen Consultant of: AbbVie, Celgene Corporation – consultant, Speakers bureau: Grunenthal, Sobi – speakers bureau, Grant/research support from: ReumaNederland, Olatec, Grunenthal – grant/research support, Sylvia de Jong Shareholder of: Employee of Amgen Inc, Employee of: Employee of Amgen Inc, Antonio Castiglia Shareholder of: Employee of Amgen Inc, Employee of: Employee of Amgen Inc, Marijn Vis Consultant of: AbbVie, Celgene Corporation, Eli Lilly, Novartis, Pfizer, Grant/research support from: Novartis, Pfizer, AbbVie, Celgene Corporation, Eli Lilly, Novartis, Pfizer.
38
Harousseau, Jean-Luc, Michel Attal, Philippe Moreau, Frédéric Garban, Thierry Facon, and Hervé Avet-Loiseau. "The Prognostic Impact of Complete Remission (CR) Plus Very Good Partial Remission (VGPR) in a Double-Transplantation Program for Newly Diagnosed Multiple Myeloma (MM). Combined Results of the IFM 99 Trials." Blood 108, no. 11 (November 16, 2006): 3077. http://dx.doi.org/10.1182/blood.v108.11.3077.3077.
Full textAbstract:
Abstract Introduction. In MM, the impact of CR achievement is still a matter of debate. In the IFM 90 and IFM 94 trials the achievement of CR (negative electrophoresis with or without negative immunofixation) plus very good partial remission (90% reduction of the M-component) was significantly associated with longer overall survival (OS) (M. Attal et al: NEJM1996;348:1875–83 and M. Attal et al; NEJM2003; 349: 2495–502). We wanted to check the impact of this simple way of response assessment in a program of double transplantation designed with the objective of increasing the CR rate. Methods. In the risk-adapted IFM 99 trials, therapeutic strategy was based on the assessement of two adverse prognostic factors (β2 microglobulin > 3 mg/L; del (13) by FISH analysis). All patients up to 65 years of age were to receive a double transplantation after an induction treatment with 3–4 courses of VAD. In standard risk MM (0 or 1 adverse prognostic factors), patients received a double autologous stem-cell transplantation (ASCT) (Melphalan 140 mg/m2/Melphalan 200 mg/m2) and were there randomized between no further treatment, pamidronate, or Thalidomide plus pamidronate (IFM 99/02). In high risk MM (2 adverse prognostic factors), patients received a first ASCT (after Melphalan 200 mg/m2) followed by either a reduced-intensity allogeneic SCT if an HLA-identical sibling was available (IFM 99/03) or a second ASCT (after Melphalan 220 mg/m2 ± anti IL-6 antibody) (IFM 99/04). Results. With a median follow-up time of 47 months, the median event-free survival (EFS) was 39 months and the probability of 5-year OS was 62%. Best response to treatment was assessed in 849 patients: CR was achieved in 274 patients (32%) and VGPR in 191 patients (22.5%), while 311 patients (37%) had only a partial remission (PR) and 73 pts (8.5%) had a stable or progressive disease. Median EFS and 5-year OS were respectively 42 months and 77% for patients who achieved CR, 38 months and 63% for patients with VGPR, 30 months and 55% for patients with PR. The outcome was significantly better for the 465 patients with at least 90% reduction of their M-component (CR+VGPR) than for the 384 patients with < PR (median EFS 40 months versus 28 months, p=7.10–6) and 5-year OS 72% versus 52%, p=6.10–6). Response to the induction treatment with VAD was assessed in 700 patients: 112 (16%) had at least a VGPR. As compared to the 588 with less than VGPR there was no difference in EFS or in OS (p=0.23 and p=0.67 respectively, logrank test). Conclusion. In the context of a double transplantation program, CR + VGPR is obtained in 54.5 % of patients. We confirm that the quality of response is significantly correlated to the outcome and that achievement of CR + VGPR which can be assessed by very simple means, has a strong prognostic impact. We were not able to show a benefit of achieving CR+ VGPR after the induction treatment with VAD but 353/465 (76%) achieved this status only after the double transplant program.
39
D, Thirusenduraselvi, and Jerlin R. "Enhancing the storability of bitter gourd cv. CO 1 by pelleting treatments." Madras Agricultural Journal 94, July (2007): 192–204. http://dx.doi.org/10.29321/maj.10.100664.
Full textAbstract:
A storage study was carried out in the Department of Seed Science and Technology, TNAU, Coimbatore during 2001-03 to assess the storage potential of pelleted seeds with different botanicals viz., arappu (Albizia amara), pungam (Pongamia pinnata), neem (Azadirachta indica), notchi (Vitex negundo) and vasambu (Achorus calamus). The treated seeds were kept in moisture vapour pervious (cloth bag) and moisture vapour proof (700 gauge polythene bag) containers under ambient conditions for six months. With regard to seed quality attributes, significant differences were observed among seed treatments, storage containers and periods of storage. The seed quality evaluations at monthly intervals revealed that increasing trend in germination per cent, speed of germination, drymatter production, vigour index, electrical conductivity, moisture content and free fatty acid content were observed with the increase in storage period. Among the seed pelleting treatments, seeds pelleted with arappu leaf powder showed superiority over other treatments and control. Arappu pelleting treatment proved to be the best in maintaining vigour and viability of seed throughout the storage period of six months. Reduction of oil content in arappu treatment was less compared to other treatments and control. Pelleting with neem leaf powder showed poor performance. With regard to containers, 700 gauge polyethylene bag proved to be superior to cloth bag in maintaining germination, vigour and drymatter production. With the advance in the storage period, an increase in electrical conductivity, moisture and free fatty acid content of seed were observed.
40
Itzykson, Raphael, Alex Smith, Theo M. de Witte, Jackie Droste, Reinhard Stauder, Argyris Symeonidis, Eva Hellstrom-Lindberg, et al. "Prognostic Relevance of the Kinetics of Worsening of Cytopenias in Lower-Risk MDS: A Substudy From the European Leukemianet Low Risk MDS (EUMDS) Registry." Blood 120, no. 21 (November 16, 2012): 700. http://dx.doi.org/10.1182/blood.v120.21.700.700.
Full textAbstract:
Abstract Abstract 700 Purpose: Prognosis of lower (IPSS low/int-1) risk MDS is heterogeneous. Current prognostic systems rely on single time point cytopenia values (Hb level, ANC, PLT counts) at diagnosis (classical or revised IPSS [IPSS-R] Greenberg, Blood 2012) or during evolution (time-dependent IPSS/WPSS). Capturing the dynamics of continuous parameters can yield independent prognostic information as exemplified by lymphocyte time doubling in CLL. We analyzed the prognostic relevance of the kinetics of Hb, ANC and PLT in lower-risk MDS patients (pts) included in the prospective EUMDS registry. Methods: Among the first 1000 pts included in the EUMDS registry, those fulfilling the following criteria were analyzed here: a) IPSS low/int-1; b) ≥3 visits (planned every 6 months) with ≥12 months follow-up; c) not treated with hypomethylating agents, G-CSF, hydroxyurea or lenalidomide. Dynamics of Hb, ANC, and PLT were studied by deriving linear models of each variable for each pt. Only pts with ≥3 measures of Hb, ANC and PLT and with stable or worsening corresponding cytopenia (model slope ≤0) were considered in each analysis, regardless of the goodness of fit (R2) of models. Time (T) to lose 1 g/dL of Hb (THb), 1.0 x109/L of ANC (TANC) and 50 x109/L of PLT (TPLT) were derived with the formula: T ∼ 1/slope. All survival analyses were made from the date of registry entry to last follow-up, death, or progression to AML. Unless specified, survival analyses were Cox models using continuous variables accounting for interactions. Results: 530 pts met study inclusion criteria (M/F: 314/216, median age: 73y). WHO diagnosis was 5q- syndrome, RA, RARS, RCMD, RCMD-RS, RAEB-1 and MDS-U in 5, 21, 20, 38, 7, 8 and 2% respectively (resp). IPSS risk was low, int-1 and low/int-1 (cytogenetics not available) in 55%, 38% and 7% resp. At registry entry, median Hb, ANC and PLT were 10.4 g/dL, 2.4 x109/L and 187 x109/L resp. and 23% were RBC transfusion-dependent; 293 received an ESA. The median number of available blood counts was 4 (range 3–9). THb, TANC and TPLT could be determined because of a stable or worsening cytopenia (slope ≤0) in 250/508, 258/495 and 301/509 pts with ≥3 values. There was no significant correlation between the number of values available and the goodness-of-fit (R2) of linear models (all P>0.3). Median THb TANC and TPLT were 23.5 (interquartile range [IQR]: 42.2), 28.7 (IQR: 52.1) and 26.9 (IQR: 49.2) months respectively. Because these figures are derived from linear models, they can be simply rescaled by a proportional extrapolation for daily practice (eg. −1 x109/L ANC at 28.7 months = −0.41 x109/L [12/28.7] at 12 months). THb, TANC and TPLT were not correlated to age, cytogenetic risk, IPSS, IPSS-R or baseline simplified WPSS (Malcovati. Haematologica 2011; all P>0.2). TANC and TPLT (but not THb) were shorter in pts with baseline RBC transfusion dependence (P=.02 and .003, resp.). With a median follow-up of 20.9 months in the 530 pts, 19 patients have progressed (AML: 14, RAEB: 5) and 71 patients have died; 3-year estimates of overall (OS) and progression-free (PFS) survivals were 74.4% and 73.6%. All further analyses are shown for OS and give similar results for PFS. In univariate analysis, longer TANC (hazard ratio [HR] for 6-months increments: 0.88 [95% CI: 0.80–0.97], P=.008) and TPLT (HR: 0.01 [95% CI: 0.001–0.30], P=.007) but not THb (P=.07) were associated with prolonged OS. Pts with a ≥1 x109/L decrease in ANC in less than the median time of 28.7 months (N=129) had a 3-year OS of 66.3% [95% CI: 55.0–79.9%] vs 89.3% [79.7–100%]. Pts with a ≥50 x109/L decrease in PLT in less than the median of 26.9 months (N=151) had a 3-year OS of 59.4% [46.8–75.4%] vs 85.6% [77.5–94.6%] (Figure, both P<10−4). There was no significant difference in the cause of death between those subgroups. In multivariate analysis, the prognostic impact of TANC and TPLT remained independent of baseline IPSS (P=.006 and P=.01 resp.) or IPSS-R (both P=.01), and of simplified time-dependent WPSS (P=.004 and P=.03). A landmark analysis at 2 years, using only retrospective data to derive TANC and TPLT is planned. Conclusion: In lower-risk MDS with stable or worsening cytopenias, kinetics of decline can be approximated to be linear to allow easy prognostic use in clinical practice. Faster decline of ANC and to a lesser extent of PLT counts, but not of Hb level (possibly because of transfusions and use of ESA), is associated with shorter OS and PFS, independently of IPSS, IPSS-R and WPSS. Disclosures: Germing: Celgene: Honoraria, Membership on an entity's Board of Directors or advisory committees.
41
Giona, Fiorina, Angela Amendola, Luciana Teofili, Giovanna Palumbo, Francesca Mancini, Vittorio Nunes, Massimiliano Rea, Maurizio Martini, and Robert Foa. "Hereditary Thrombocythemia: Clinical Characteristics, Biological Markers and Long-Term Follow-up in 4 Families Observed in a Single Hematologic Pediatric Center." Blood 112, no. 11 (November 16, 2008): 5226. http://dx.doi.org/10.1182/blood.v112.11.5226.5226.
Full textAbstract:
Abstract Hereditary thrombocytosis (HT) is an autosomal dominant disorder resulting from mutations involving the thrombopoietin (TPO) gene or its receptor gene, MPL. To date, 4 different mutations in the TPO gene and 2 in the MPL gene have been described. Although the clinical features of HT can resemble those of sporadic essential thrombocytemia (ET), different biological markers characterize the two conditions with different clinical and biological characteristics. The presence of JAK2 V617F and MPLW515L mutations identify familial ET (variable penetrance, clinical features and outcome similar to those of sporadic ET). The absence of JAK2 V617F mutations and the presence of MPLS505A or TPO gene mutations characterize HT (complete predominance, thrombocytosis, no organomegaly and benign clinical course). In our study, we analyzed the clinical and biological features of 17 members of 4 families (fam), diagnosed and followed at the study Institution between 1979 and 2007. The median follow-up is 79 months. Of 49 patients (pts) aged ≤20 years with a diagnosis of ET according to the PVSG or WHO criteria, we have identified 17 pts (M: 8; F: 9; median age 14 years) with HT (34.7%) through a detailed history. Peripheral blood samples were collected after informed consent from 11/17 pts: molecular analysis for the JAK2V617F, TPO (5′ untranslated region) and MPL (exon 10) gene mutations was performed. In addition, all pts were also evaluated for PRV-1 RNA overespression by qualitative RT-PCR, for endogenous erythroid colony (EECs) growth and all female patients were tested for clonality of hematopoiesis using the HUMARA polymorphism assay and the HUMARA methylation-specific PCR. The table summarizes the features, treatment and follow-up of the pts. Sex/Age at diagnosis (yrs) Plts at diagnosis (× 109/l) JAK2 V617F PRV-1 EECs Clonality MPL mutation Treatment Follow-up (FU) Plts (× 109/l) FU Duration (mo) *N.T.=Not tested Fam 1 M/18 900 neg neg neg - MPLS505A NO PLT≤1,000 >330 M/88/12 1,459 neg neg neg - MPLS505A AT PLT≤500 >79 F/20 934 N.T.* N.T. N.T. N.T. N.T. AT; Anagrelide-> Vercite ->HU->IFN PLT≤500 Lost to FU 184 Fam 2 M/18 700 neg pos neg - MPLS505A AT HUà stop C hepatitis PLT≤1,000 >228 M/114/12 783 neg neg neg - MPLS505A NO PLT<1,000 >39 F/165/12 963 neg pos pos Poly MPLS505A NO PLT≤1,500 >129 F/173/12 695 neg pos neg Poly MPLS505A NO PLT≤1,000 >39 F/92/12 1,230 N.T. N.T. N.T. N.T. N.T. NO PLT≤1,000 Lost to FU 47 F/14 932 N.T. N.T. N.T. N.T. N.T. NO PLT≤1,000 Lost to FU 42 Fam 3 F/149/12 1,060 neg pos pos Poly MPLS505A AT 1 pregnancy PLT≤1,000 >229 M/03/12 1,528 neg pos pos - MPLS505A NO PLT ≤1,500 >44 F/1010/12 611 neg pos neg Poly MPLS505A NO PLT<1,000 >131 M/103/12 759 N.T. N.T. N.T. N.T. N.T. NO PLT<1,000 Lost to FU 49 M/14 2,950 N.T. N.T. N.T. N.T. N.T. Verciteà HU PLT<1,000 Lost to FU 72 F/38/12 1,430 N.T. N.T. N.T. N.T. N.T. NO PLT<1,000 Lost to FU 36 Fam 4 M/1911/12 690 neg pos pos - No mutation AT HUàAnagrelide Previous splenectomy PLT<1,000 >86 F/178/12 1,118 neg neg neg Poly No mutation AT, HU->Anagrelide->IFN PLT<1,000 >144 Mild splenomegaly was present in 2 pts (family 4). All pts were negative for JAK2V617F and TPO gene mutations. All females were polyclonal. In 9 pts of families 1, 2 and 3 studied for MPL mutations, the MPLS505A mutation was found. No mutations within the TPO or MPL genes were found in the affected members of family 4. Overall, 6 pts received antiaggregant therapy (AT) and 5 pts were treated with hydroxyurea (HU), interferon (IFN), pipobroman (vercite) or anagrelide. No thromboembolic events occurred. To date, 2/11 evaluable pts (family 4) have required treatment because of a persistent high platelet count. Our data suggest that ET in young pts is most frequently a familial form. A detailed history and accurate biological marker studies are needed to identify, characterize and better manage HT.
42
Chang, Jiyul, Sharon A. Clay, David E. Clay, and Kevin Dalsted. "Detecting weed-free and weed-infested areas of a soybean field using near-infrared spectral data." Weed Science 52, no. 4 (August 2004): 642–48. http://dx.doi.org/10.1614/ws-03-074r1.
Full textAbstract:
Weed distribution maps can be developed from remotely sensed reflectance data if collected at appropriate times during the growing season. The research objectives were to determine if and when reflectance could be used to distinguish between weed-free and weed-infested (mixed species) areas in soybean and to determine the most useful wavebands to separate crop, weed, and soil reflectance differences. Treatments included no vegetation (bare soil), weed-free soybean, and weed-infested soybean and, in 1 yr, 80% corn residue cover. Reflectance was measured at several sampling times from May through September in 2001 and 2002 using a handheld multispectral radiometer equipped with band-limited optical interference filters (460 to 1,650 nm). The spatial resolution was 0.8 m2. The reflectance in the visible spectral range (460 to 700 nm) generally was similar among treatments. In the near-infrared (NIR) range (> 700 to 1,650 nm), differences among treatments were observed from soybean growth stage V-3 (about 4 wk after planting) until mid-July to early August depending on crop vigor and canopy closure (76-cm row spacing in 2001 and 19-cm row spacing in 2002). Reflectance rankings in the NIR range when treatments could be differentiated were consistent between years and, from lowest to highest reflectance, were soil < weed-free < weed-infested areas. Increased reflectance from weed-infested areas was most likely due to increased biomass and canopy cover. Residue masked differences between weed-free and weed-infested areas during the early stages of growth due to high reflectance from the residue and reduced weed numbers in these areas. These results suggest that NIR spectral reflectance collected before canopy closure can be used to distinguish weed-infested from weed-free areas.
43
Kurtina, Daria A., Alexey V. Garshev, Larisa D. Kozina, and Roman B. Vasiliev. "Atomically-Thin CdSe and CdTe Colloidal Nanosheets: Growth, Crystal Structure, and Optical Properties." Vestnik RFFI, no. 3 (July 31, 2019): 26–34. http://dx.doi.org/10.22204/2410-4639-2019-103-03-26-34.
Full textAbstract:
The article describes the main features of a new class of colloidal nanoparticles with the electronic structure of semiconductor quantum wells – atomically-thin cadmium selinide CdSe and cadmium telluride CdTe nanosheets with a thickness of 1-2 nm and extended lateral sizes in the range of 100–700 nm. Approaches to the synthesis of such nanostructures by wet chemical methods are considered. A new effect of spontaneous folding induced by ligand exchange has been described.
44
LOUIS, A., A. BALK, U. JANSSENS, and J. CLELAND. "700 Telemonitoring for patients with heart failure at high risk for readmission and death. The Trans-European Network Home Monitoring Study (TEN-HMS)." European Journal of Heart Failure Supplements 2, no. 1 (June 2003): 145. http://dx.doi.org/10.1016/s1567-4215(03)90440-1.
Full text
45
Kursumovic, A., R. Hühne, R. Tomov, B. Holzapfel, B. A. Glowacki, and J. E. Evetts. "Investigation of the growth and stability of (1 0 0)[0 0 1] NiO films grown by thermal oxidation of textured (1 0 0)[0 0 1] Ni tapes for coated conductor applications during oxygen exposure from 700 to 1400 °C." Acta Materialia 51, no. 13 (August 2003): 3759–68. http://dx.doi.org/10.1016/s1359-6454(03)00190-3.
Full text
46
Khorana, Alok, Saroj Vadhan-Raj, Nicole Kuderer, Ted Wun, Howard Liebman, Gerald Soff, Chandra Belani, et al. "Rivaroxaban for Preventing Venous Thromboembolism in High-Risk Ambulatory Patients with Cancer: Rationale and Design of the CASSINI Trial." Thrombosis and Haemostasis 117, no. 11 (November 2017): 2135–45. http://dx.doi.org/10.1160/th17-03-0171.
Full textAbstract:
AbstractVenous thromboembolism (VTE) is a frequent complication of cancer associated with morbidity, mortality, increased hospitalizations and higher health care costs. Cancer patients at increased risk for VTE can be identified using a validated risk assessment score, and the incidence of VTE can be reduced in high-risk settings using anticoagulation. Rivaroxaban is a potent, oral, direct, factor Xa inhibitor approved for the prevention and treatment of thromboembolic events, including VTE. CASSINI is a double-blind, randomized, parallel-group, multicentre study comparing rivaroxaban with placebo in adult ambulatory patients with various cancers who are initiating systemic cancer therapy and are at high risk of VTE (Khorana score ≥ 2). Patients with primary brain tumours or those at risk for bleeding are excluded. Approximately 700 patients will be randomized 1:1 to rivaroxaban 10 mg daily or placebo for up to 6 months if there is no evidence of VTE from compression ultrasonography (CU) during screening or from routine care imaging within 30 days prior to randomization. Mandatory CU will also be performed at weeks 8 and 16 (±7 days), and at study end (±3 days). The primary efficacy hypothesis is that anticoagulation with rivaroxaban reduces the composite of objectively confirmed symptomatic or asymptomatic, lower-extremity, proximal deep-vein thrombosis (DVT); symptomatic, upper-extremity DVT; symptomatic or incidental pulmonary embolism; and VTE-related death compared with placebo. The primary safety objective is to assess major bleeding events (Clinical trial information: NCT02555878).
47
Koegel, Sally, Olivier Braissant, Tuomas Waltimo, Michael M. Bornstein, and Monika Astasov-Frauenhoffer. "Evaluation of antibacterial properties of fluoride-containing mouth rinses differing in their acidic compound using a Streptococcus mutans biofilm." SWISS DENTAL JOURNAL SSO – Science and Clinical Topics 133, no. 3 (March 6, 2023): 156–63. http://dx.doi.org/10.61872/sdj-2023-03-01.
Full textAbstract:
This in vitro study assessed the antibacterial effect on Streptococcus mutans biofilms of mouth rinses with 700 ppm F- (derived from NaF) that differed only in their acid compounds (malic, citric, tartaric, fumaric, hydrochloric, phosphoric, and lactic acid) used to adjust pH.
S. mutans (ATCC™ 25175) was grown for 22 h at 37°C, harvested, resuspended in simulated body fluid and biofilm formation followed for 24 h at 37°C. Thereafter, biofilms were treated with experimental rinses for 30 s and placed in TAM48 isothermal microcalorimeter at 37°C for 72 h. Applying Gompertz growth model the parameters lag time and growth rate were determined from heat flow curves; additionally, reduction of active biofilms was calculated. Moreover, samples were live/dead-stained and analysed by confocal scanning microscopy.
All mouth rinses were showing statistically significant lag time and reduction of active biofilm (p < 0.05, A 19.1 ± 2.3 h and 58.5 ± 7.7%, B 15.5 ± 1.1 h and 41.9 ± 5.3%, C 17.6 ± 1.9 h and 53.1 ± 7.5%, D 18.4 ± 2.4 h and 55.8 ± 8.8%, E 20.2 ± 3.3 h and 61.5 ± 10.0%, F 20.2 ± 3.0 h and 61.6 ± 9.3%, and G 18.3 ± 2.5 h and 55.3 ± 8.9%). Interestingly, there were no differences found between the treated groups (p > 0.05, A 0.064 ± 0.004 1/h, B 0.063 ± 0.005 1/h, C 0.065 ± 0.004 1/h, D 0.067 ± 0.004 1/h, E 0.066 ± 0.006 1/h, F 0.067 ± 0.004 1/h, G 0.066 ± 0.006 1/h) for the maximum growth rate. Vitality staining supported these findings.
The present investigation demonstrates that the type of acid compounds used to produce the rinses did not show any negative effect on the antimicrobial properties of the tested products as all of them exhibited a similar efficacy against S. mutans biofilms.
48
Luc, Nhu-Quynh, Duc-Huy Quach, Chi-Hung Vu, Hong-Truong Nguyen, and Thanh-Long Vo-Khac. "Integration of an RSA-2048-bit public key cryptography solution in the development of secure voice recognition processing applications." Ministry of Science and Technology, Vietnam 65, no. 3 (September 15, 2023): 3–7. http://dx.doi.org/10.31276/vjste.65(3).03-07.
Full textAbstract:
The authors initially employs the fast Fourier transform (FFT) approach to transforming voice inputs into digital signals before integrating a speech recognition solution (which includes two models: the hidden Markov model (HMM) and the artificial neural network (ANN)). To achieve standard-tone identification of voice signals and digitally store speech, the authors then incorporated a 2048-bit Rivest-Shamir-Adleman (RSA) encryption method to encrypt and decrypt digital speech. The authors’ building team constructed the program using a 256-bit advanced encryption standard - Galois counter mode (AES-GCM) encryption method to assure the application’s effectiveness. The authors successfully created a voice recognition application according to the HMM of ANN. The collected findings suggest that the authors’ secure speech recognition program (named soft voice - RSA) has improved in terms of safety, keeping speech material secret, and speed. It takes roughly 0.2 s to generate a 2048-bit RSA key pair that exceeds the National Institute of Standards and Technology (NIST) standard, 700-1070 ms to process speech, 1-4 ms to encrypt 2048-bit RSA, 6-8 ms to decrypt 2048-bit RSA.
49
Dumas, J., and P. Prouzet. "Variability of demographic parameters and population dynamics of Atlantic salmon Salmo salar L. in a south-west French river." ICES Journal of Marine Science 60, no. 2 (January 1, 2003): 356–70. http://dx.doi.org/10.1016/s1054-3139(03)00003-1.
Full textAbstract:
Abstract The abundance of the salmon population in the Nivelle River was assessed for 11 cohorts during all the stages of their life cycle, from eggs to spawners. A stochastic life history model was used to simulate the changes in numbers at each stage over several years and to evaluate the parameters of a Ricker-type Stock and Recruitment (S–R) relationship. Parameters necessary for managing the exploitation of the species were also estimated. The results indicated that an average deposition of 611 700 eggs (values varying in a proportion of 1 to 3, depending on the year) produced 4870 0+ parr in autumn (variation from 1 to 5.6); 71.8% of which belonged to the group of future 1-year old smolts. The age 1+ parr were eight times less numerous. Survival from egg to 0+ parr was on average 0.97%, but highly variable (varying from 1 to 15). It was density-dependent and followed Ricker S–R model with an optimum of 7800 parr for a survival rate of 3%. During their second year, the survival of 1+ parr reached 53.4% and varied little. The adult runs of complete cohorts amounted to 196 maiden salmon (range, 88 to 382) and previous spawners comprised only 0.9% of adults. Grilse (1 year in the sea) constituted the majority (88.7%). The overall survival rates from 0+ parr to adult returns (6.2% on average) varied three-fold. The majority was females among the grilse (56.2%) and 2-sea-year salmon (88.6%); all 3-sea-year adults were female. Eggs deposited per female averaged 4200, 8500 and 12 750 eggs in each age group, respectively. Simulations of population abundances at various life stages were in good agreement with the observed data. The S–R relationship revealed the low productivity and the vulnerability of this stock, mainly due to the low survival rate of the young during their first year of life. The maximum yield of 12.2% of recruits could be obtained from a deposition of 1 424 000 eggs, which is twice the present average level.
50
Ivanov, A., and A. Betin. "The effectiveness of the use of feed additive Agolin Ruminant in the rations of lactating cows." Glavnyj zootehnik (Head of Animal Breeding), no. 4 (April 1, 2020): 29–35. http://dx.doi.org/10.33920/sel-03-2004-04.
Full textAbstract:
An important task for livestock farms is the use of plant feed extracts to improve the effectiveness of dairy production. The development of new alternative drugs based on natural plants allows for the biological protection of animals. Agolin Ruminant is multi-functional feed additive is a mixture of high-quality active ingredients of plant origin, which is designed to optimize consumption and improve feed conversion in the dairy industry. The purpose of the work was to find the increase in the productivity of high-yield cows by using feed additives based on plant extracts on a large number of animals. Production tests have been carried out in the dairy complex of LLC “Tambov-milk” in the Tambov region on Holstein cows with actual productivity at the level of 8500–9000 kg of milk per year. Analysis of cow productivity indicates a positive effect of the introduction of the feed additive Agolin Ruminant in the ration of animals. For example, in the control group of cows for 30 days of lactation the average daily milk yield from 1 cow was 27,44 kg, in the experimental group 28,14 kg, which was more than 700 g or 2,55 %. The introduction of the Agolin Ruminant feed additive into the ration of animals in the experimental group had a positive effect on the fat content in milk, which at the end of the research period was 3,69 % in the control group, and 3,71 % in the experimental group or 0,02 abs.% higher. The protein content in milk in the control group of cows was 3,16 %, and in the experimental group 3,18 % the excess was also equal to 0,02 abs.%. Economic calculations indicate the effectiveness and expediency of using the Agolin Ruminant feed additive in feeding highly productive cows. At the sale price of 1 kg of milk for 29,0 rubles the productivity of cows have been increased by 0,7 kg, and the income from 1 head per day has increased by 17,3 rubles minus the cost of feed additive.