Relevant bibliographies by topics / 666.766 : 546

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Academic literature on the topic '666.766 : 546'

Author: Grafiati
Published: 30 May 2022
Last updated: 31 May 2022

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Journal articles on the topic "666.766 : 546"

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Theodosoglou, E., A. Koroneos, T. Soldatos, T. Zorba, and K. M. Paraskevopoulos. "COMPARATIVE FOURIER TRANSFORM INFRARED AND X-RAY POWDER DIFFRACTION ANALYSIS OF NATURALLY OCCURRED K-FELDSPARS." Bulletin of the Geological Society of Greece 43, no. 5 (July 31, 2017): 2752. http://dx.doi.org/10.12681/bgsg.11681.

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Natural K-feldspars from igneous rocks have been examined by means of X-ray powder diffraction(XRPD) and Fourier transform infrared (FTIR) spectroscopy in the spectral range 400-1400 cm-1,where the Si-Al-O bonds exhibit the dominant vibrations. From the XRPD analysis three specieshave been distinguished, i.e. microclines (3 samples), orthoclases (4 samples) and sanidines (3 samples);their unit cell parameters were calculated. The FTIR transmittance spectra of all sampleshave common bands at 426, 463, 584, 604, 726 and 772 cm-1 and some additional features. The spectraof sanidine and orthoclase exhibit fewer and broader bands than the microclines’, especially inthe area 1000-1200 cm-1. The differences in their spectra are located in four bands. The bands ataround 536-538 and 646-648 cm-1 in the spectrum of microcline, are shifted at around 542-544 and640-642 cm-1 in the spectrum of orthoclase and at around 546 and 636 cm-1 in the spectrum of sanidine.Four bands at 1010, 1050, 1090 and 1136 cm-1 in the spectra of microcline are substitutedwith two quite broad bands at about 1030 and 1125 cm-1 in the spectra of orthoclase and sanidine.These differences are attributed to different degree of Al-Si ordering in the structure of K-feldspars.
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Weaver, M. L., J. M. Tanzer, and P. A. Kramer. "Salivary Flow Induction by Buccal Permucosal Pilocarpine in Anesthetized Beagle Dogs." Journal of Dental Research 71, no. 11 (November 1992): 1762–67. http://dx.doi.org/10.1177/00220345920710110101.

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We tested whether permucosal delivery of pilocarpine nitrate could be used to elicit significant salivary secretion. Pilocarpine (pKa 6.6 at 37°C) was applied as solutions (pHs 5.6, 6.6, 7.6; 15 mg/mL) to the buccal mucosa (2.8 cm2) of 6 anesthetized dogs. Saliva was collected continuously from cannulated submandibular and parotid ducts and blood sampled during and after drug administration. Plasma pilocarpine levels were determined by reversed-phase HPLC. Absorption rates were determined by use of data from separate zero-order intravenous infusions to the same dogs. Pilocarpine was buccally absorbed at a constant rate of 72.9 ± 38.5 μg/kg/h following its application at pH 7.6. At this pH of the drug solution, the time to appearance of pilocarpine in blood plasma was 0.31 ± 0.08 h, and the time to appearance of salivary flow was 0.86 ± 0.32 h. A threshold dose of 32.9 ± 7.5 ug/kg was required to induce secretion with the pH 7.6 drug, the steady-state plasma concentration was 28.9 ± 19.3 ng/mL, and the steady-state submandibular flow rate was 0.14 ± 0.11 mL/ min/gland pair. Salivary flow induction was symmetrical and reached levels as high as 0.35 mL/min/submandibular gland pair without apparent tachyphylaxis. Results at pHs 5.6, 6.6, and 7.6 were consistent with the hypothesis that pilocarpine is primarily absorbed as un-ionized drug. The data indicate that transmucosal delivery of pilocarpine, avoiding "first pass" hepatic loss, may hold promise for the treatment of xerostomia.
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Maslennikova, N. A., E. Yu Sergeeva, E. P. Tikhonova, A. Yu Burakov, N. M. Titova, Yu A. Fefelova, and T. G. Ruksha. "Antioxidant system blood enzymes activity in patients with echinococcosis." Kazan medical journal 95, no. 4 (August 15, 2014): 531–33. http://dx.doi.org/10.17816/kmj1837.

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Aim. To study the activity of antioxidant enzymes and concentration of malondialdehyde - lipid peroxidation product - in patients with echinococcosis. Methods. 22 patients aged 32 to 74 years [females - 9 (40%), males - 13 (60%), mean age 37.6 years] with established diagnosis of liver echinococcosis confirmed by ELISA, were examined. Mean disease duration was 10 years. 12 patients, in whom the diagnosis of liver echinococcosis was excluded, were included in the control group. Superoxide dismutase activity was determined based on adrenaline auto-oxidation inhibition, as well as catalase activity and malondialdehyde level were determined. Results. Statistically significant decrease in the malondialdehyde concentration from 5.9 [5.6÷6.6] to 3.7 [3.3÷4.1] mmol/g of hemoglobin (p 0.001), superoxide dismutase activity - from 764 [744÷796] to 666 [627÷695] i.u./min.×g of hemoglobin (p 0.001) was revealed in patients with echinococcosis. Catalase activity did not change significantly (maintained at the level of control group), which may indicate a temporary activation of the compensatory abilities of the body. Conclusion. Revealed data suggest that gradual development of oxidative stress and decrease in body adaptive abilities play a significant role in the pathogenesis of liver echinococcosis which should be considered while working out the new treatment options for the disease.
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Nichols, Anthony C., Michelle Chan-Seng-Yue, John Yoo, Wei Xu, Sandeep Dhaliwal, John Basmaji, Christopher C. T. Szeto, et al. "A Pilot Study Comparing HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas by Whole Exome Sequencing." ISRN Oncology 2012 (December 12, 2012): 1–9. http://dx.doi.org/10.5402/2012/809370.

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Background. Next-generation sequencing of cancers has identified important therapeutic targets and biomarkers. The goal of this pilot study was to compare the genetic changes in a human papillomavirus- (HPV-)positive and an HPV-negative head and neck tumor. Methods. DNA was extracted from the blood and primary tumor of a patient with an HPV-positive tonsillar cancer and those of a patient with an HPV-negative oral tongue tumor. Exome enrichment was performed using the Agilent SureSelect All Exon Kit, followed by sequencing on the ABI SOLiD platform. Results. Exome sequencing revealed slightly more mutations in the HPV-negative tumor (73) in contrast to the HPV-positive tumor (58). Multiple mutations were noted in zinc finger genes (ZNF3, 10, 229, 470, 543, 616, 664, 638, 716, and 799) and mucin genes (MUC4, 6, 12, and 16). Mutations were noted in MUC12 in both tumors. Conclusions. HPV-positive HNSCC is distinct from HPV-negative disease in terms of evidence of viral infection, p16 status, and frequency of mutations. Next-generation sequencing has the potential to identify novel therapeutic targets and biomarkers in HNSCC.
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Kutluk, M. Tezer, and Akif Yeşilipek. "Pediatric cancer registry in Turkey 2009-2020 (TPOG & TPHD)." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): e22519-e22519. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e22519.

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e22519 Background: Global actions on pediatric cancer control is targeting to improve the survival rates in low and middle income countries which already exceeded 80% in high income countries. Almost 300.000 pediatric cancer cases annually are expected in children and adolescents aged 0-14 globally. Pediatric cancer registry must be a priority within the pediatric cancer control programs. Here, we present the most updated results of the pediatric cancer registry in Turkey. Methods: Pediatric cancer registry has been established by the Turkish Pediatric Oncology Group and Turkish Pediatric Hematology Association in 2002. The childhood cancer cases registered between 2009-2020 was included in this analysis. International Childhood Cancer Classification System was used for the classification. Essential demographic findings, ICD-O-3 morphology and topography codes were recorded for each case. Results: During the 12 years from 2009 to 2020, 21792 cases were registered. For all cases, median age was 6.7 year (0-19; M/F 12198/9584, 4 hermaphrodite, 6 unknown). Age distribution was 0-4 yrs, 40.9%; 5-9 yrs, 23.7%; 10-14 yrs, 23.4%; 15-19 yrs, 12.0%) The distribution of the tumor types were [number of cases, percentage of total, median age yrs, M/F]: Leukemia (5208, 23.9%, 5.5, 3004/2204); Lymphoma & other RES tumors (4103, 18.8%, 9.8, 2733/1367, 1 hermaphrodite & 2 unknown); CNS [brain & spinal] (3269, 15.0%, 6.8, 1794/1474, 1 unkown); Symphatetic system (1794, 8.2%, 2.4, 933/861); Retinoblastoma (610, 2.8%, 1.4, 339/271); Renal (1079, 5.0%, 3.1, 524/553, 1 hermaphrodite & 1 unknown); Liver (376, 1.7%, 2.2, 216/160); Malignant bone (1448, 6.6%, 12.5, 787/661); Soft tissue sarcomas (1554, 7.1%, 7.6, 888/666); Germ cell (1461, 6.7%, 9.3, 547/910, 2 hermaphrodite, 2 unknown); Carcinoma & other malignant epithelial (745, 3.4%, 13.5, 362/383); Other/non-specific malignant (145, 0.7%, 7.9, 71/74). Five year survival rate was found as 72%. Conclusions: This registry shows the imrovement of survival rates to 72% in Turkey which is comparable with middle income countries. The pediatric cancer control community is investing on the control of childhood cancer for further improvement and this registry became a valuable source for pediatric oncology community at national and international level.
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Nelson, William B., Chad M. House, Patricia K. Turnquist, Jenny M. Spence, Mary A. Anstadt, Glenn A. Nickele, Katie A. Moriarty, and Charles K. Stone. "Ultra low-dose single photon emission computed tomography myocardial perfusion imaging." International Journal of Diagnostic Imaging 1, no. 2 (April 22, 2014): 54. http://dx.doi.org/10.5430/ijdi.v1n2p54.

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Background: Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) provides excellent diagnostic and prognostic information. A primary limitation of SPECT is radiation exposure. New cadmium zinc telluride (CZT) technology has allowed for reduced radiation exposure. Methods: A cohort of 414 consecutive patients undergoing very low-dose SPECT MPI utilizing CZT technology was analyzed. Patients received rest/stress dosing strategies of 111/333, 148/444, 222/666, 296/888, 370/1110 Megabecquerels (MBq) (3/9, 4/12, 6/18, 8/24, 10/30 millicuries) depending on their weight and body mass index. Image quality was visually assessed by the reading cardiologist (scale: 1 = poor; 2 = fair; 3 = good; 4 = excellent). Results: 58% of patients received 111/333MBq, 22% received 148/444MBq, 13% received 222/666MBq, 6% received 296/888MBq, and 1% received 370/1110MBq. The estimated radiation dose was 3.6, 4.8, 7.2, 9.6, and 12 millisieverts respectively. The average image quality for the cohort was 3.3 ± 0.7. The rest/stress counts (103) for 111/333 and 148/444 groups were 532 ± 212/1718 ± 525 and 545 ± 177/1748 ± 399, while the rest/stress counts (103) for the 222/666 and 296/888 groups were 673 ± 178/2235 ± 923 and 764 ± 249/2588 ± 788 respectively. The 111/333 and 148/444 groups had significantly lower counts than the 222/666 and 296/888 groups, but only the 296/888 group had a significant difference in image quality when compared to the 111/333 group, with the 111/333 group having better image quality. Conclusion: CZT technology permits rapid, very low-dose MPI studies to be performed, thus, reducing the radiation exposure for patients, while still providing high quality, diagnostic perfusion results. The majority of our patients were imaged at less than 4mSv.
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Lee, Yu-Chien, Elisabetta Patorno, Chandrasekar Gopalakrishnan, and Dae Kim. "Trends of ARNI and Other Heart Failure Medication Use in Older Adults." Innovation in Aging 5, Supplement_1 (December 1, 2021): 208–9. http://dx.doi.org/10.1093/geroni/igab046.805.

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Abstract In 2015-2017, we identified 276,679 to 315,788 Medicare beneficiaries with HFrEF (mean age 76.6-76.7 years, 75.0-76.2% male, 82.0-83.4% Whites, and 44.8-50.9% frail). Since its approval in July 2015, ARNI use increased from 0.3% to 5.7%. ARNI uptake was lower in patients with older age (6.6% for 65-74 years vs 3.4% for ≥85 years), non-Hispanic race (7.3% for Hispanic vs 5.6-6.6% for other race), no dual eligibility (6.4% for dual eligibility vs 5.5% for no dual eligibility), frailty (5.1% for frailty vs 6.1% for non-frailty) and dementia (3.8% for dementia vs 6.1% for no dementia). Frail patients were less likely than non-frail patients to receive disease-modifying treatments, such as angiotensin-converting enzyme inhibitors (32.4% vs 38.9%), angiotensin receptor blockers (14.5% vs 17.5%), aldosterone antagonists (20.8% vs 23.4%), and beta-blockers (65.1% vs 68.3%), but more likely to receive symptomatic treatment with loop diuretics (56.4% vs 48.0%).
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Beers, E. H., and E. A. Eisner. "Western Tentiform Leafminer Vydate Rate Test, 1987." Insecticide and Acaricide Tests 14, no. 1 (January 1, 1989): 1. http://dx.doi.org/10.1093/iat/14.1.1a.

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Abstract The test was conducted in a mature commercial orchard near East Wenatchee, Wash. The experimental design consisted of unreplicated 1-acre blocks. Treatments were applied on 27 Jul with an airblast sprayer delivering 400 gal/acre. The number of WTLM was sampled by counting tissue-feeding mines from the upper surfaces of 100 leaves. The pretreatment count (17 Jul) coincided with the maximum number of mines of the second generation, and the posttreatment count (19 Aug) coincided with the maximum number of mines of the third generation. WTLM age structure at time of application was 36.0% sap-feeding larvae, 6.6% tissue-feeding larvae, 5.6% pupae, and 44.2% emerged, 7.6% dead, and 0% parasitized.
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LURATI, ALFREDOMARIA, ALESSANDRA SALMASO, VALERIA GERLONI, MAURIZIO GATTINARA, and FLAVIO FANTINI. "Accuracy of Wallace Criteria for Clinical Remission in Juvenile Idiopathic Arthritis: a Cohort Study of 761 Consecutive Cases." Journal of Rheumatology 36, no. 7 (June 1, 2009): 1532–35. http://dx.doi.org/10.3899/jrheum.080434.

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Objective.To evaluate disease course and clinical usefulness in some categories of juvenile idiopathic arthritis (JIA) by applying newly developed Wallace definitions of remission off drugs.Methods.In a retrospective study, charts of patients with chronic form of primary (idiopathic) arthritis followed from our center since 1970 were reviewed and clinical/laboratory variables were collected for further analysis.Results.The cohort included 761 eligible patients [516 (67.8%) female, 245 (32.2%) male] with JIA. Mean disease onset age (± standard deviation) was 6.25 ± 4.4 years (range 0.5–15.9). Disease mean duration to last visit was 10.02 ± 4.31 years. Followup mean period was 7.6 ± 6.4 years (range 1.5–35 yrs). A total of 247 (32.46%) patients achieved remission according to criteria [persistent oligoarthritis 153 (42.9%); extended oligoarthritis 15 (13.1%); seronegative polyarthritis 21 (22.4%); systemic arthritis 33 (33.7%); enthesitis related arthritis (ERA) plus juvenile psoriatic arthritis (JPsA) 25 (33.4%)]. No patients with seropositive polyarthritis achieved remission status (p < 0.001). In remitted patients the mean survival function (± standard error of the mean) before relapse calculated by Kaplan-Meier was of 20.9 (± 1.3) months overall: 21.7 (± 0.46) in persistent oligoarthritis, 25.0 (± 6.6) in extended oligoarthritis, 26.7 (± 13.2) in seronegative polyarthritis, and 17.6 (± 2.44) in ERA+JPsA (p > 0.1).Conclusion.In our cohort about one-third of cases obtained a remission episode in 4 decades of observation, with a significant difference between oligoarthritis and other categories (p < 0.001) using the Kaplan-Meier method; the remission status duration before a relapse has been about 20 months, without a significant difference between JIA categories.
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KORNACKI, JEFFREY L., and ELMER H. MARTH. "Heat-Inactivation of Streptococcus faecium var. casseliflavus in Skim Milk Cultures with Pseudomonas fluorescens." Journal of Food Protection 49, no. 7 (July 1, 1986): 541–43. http://dx.doi.org/10.4315/0362-028x-49.7.541.

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Thermal destruction of Streptococcus faecium var. casseliflavus (SFC) at 57°C in autoclaved skim milk was determined at several pH values, and when skim milk was inoculated with Pseudomonas fluorescens and incubated 3 d at 10°C plus 4 d at room temperature before SFC was added. The pH values between 6.4 and 6.6 had little effect on heat resistance of SFC. At pH 5.6, however, accelerated thermal destruction occurred in sterile skim milk as compared to skim milk at pH 6.5. (D-values were 4.8 min and 10.2 min, respectively). Presence of large populations (log10 bacterial count = 9.8 to 9.9/ml) of P. fluorescens had a protective effect on SFC (D = 7.6 ± .7 min in skim milk preincubated with P. fluorescens and 6.2 min in skim milk without P. fluorescens).
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Dissertations / Theses on the topic "666.766 : 546"

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Beuntner, Nancy [Verfasser], Karl-Christian [Akademischer Betreuer] Thienel, Karl-Christian Gutachter] Thienel, Detlef [Gutachter] [Heinz, and Johann [Gutachter] Plank. "Zur Eignung und Wirkungsweise calcinierter Tone als reaktive Bindemittelkomponente im Zement / Nancy Beuntner ; Gutachter: Karl-Christian Thienel, Detlef Heinz, Johann Plank ; Akademischer Betreuer: Karl-Christian Thienel ; Universität der Bundeswehr München, Fakultät für Bauingenieurwesen und Umweltwissenschaften." Neubiberg : Universitätsbibliothek der Universität der Bundeswehr München, 2017. http://nbn-resolving.de/urn:nbn:de:bvb:706-5546.

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Sowade, Enrico, Thomas Blaudeck, and Reinhard R. Baumann. "Inkjet Printing of Colloidal Nanospheres." Universitätsbibliothek Chemnitz, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-188147.

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We report on inkjet printing of aqueous colloidal suspensions containing monodisperse silica and/or polystyrene nanosphere particles and a systematic study of the morphology of the deposits as a function of different parameters during inkjet printing and solvent evaporation. The colloidal suspensions act as a model ink for an understanding of layer formation processes and resulting morphologies in inkjet printing in general. We investigated the influence of the surface energy and the temperature of the substrate, the formulation of the suspensions, and the multi-pass printing aiming for layer stacks on the morphology of the deposits. We explain our findings with models of evaporation-driven self-assembly of the nanosphere particles in a liquid droplet and derive methods to direct the self-assembly processes into distinct one- and two-dimensional deposit morphologies.
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Books on the topic "666.766 : 546"

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Current public lands and forests bills: Hearing before the Subcommittee on Public Lands and Forests of the Committee on Energy and Natural Resources, United States Senate, One Hundred Twelfth Congress, first session, on S. 220, S. 270, S. 271, S. 278, S. 292, S. 322, S. 382, S. 427, S. 526, S. 566, S. 590, S. 607, S. 617, S. 667, S. 683, S. 684, S. 729, S. 766, S. 896, S. 897, May 18, 2011. Washington: U.S. G.P.O., 2011.

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Book chapters on the topic "666.766 : 546"

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Carraro, Wendy Beatriz Witt Haddad, and Monise Pasetto Soster. "Changes in Personal Financial Behavior Amid the COVID-19 Pandemic in Brazil." In Modern Regulations and Practices for Social and Environmental Accounting, 191–205. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-7998-9410-0.ch010.

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The study aims to identify changes in personal financial behavior in the midst of the COVID-19 pandemic. Data from 796 participants of the Extension Project 'Financial Education in Times of COVID-19', between April/2020 and February/2021, were analyzed. It is characterized as qualitative, quantitative, and descriptive research with a survey. The results indicate that 66% of respondents are women, 47% are married, 54% are between 25 and 44 years old, and 32% are financiers. Regarding financial behavior during the pandemic, 52% of the participants make a shopping list to go to the supermarket and search for cheaper brands, and 56% noticed an increase in expenses. Respondents changed their behavior and expanded their control over finances, starting to reflect more when buying. The research contributes, highlighting the importance of education and the use of money in facing financial crises. It enriches the literature regarding education and financial behavior in times of pandemic.
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--. "II. DARSTELLUNGEN 1.Literaturkritische Essays, Werkanalysen, Interpretationen und Abhandlungen zu Einzelaspekten Nr. 296-349 2. Dissertationen und Diplomarbeiten Nr. 350-356 3. Artikel und Hinweise in Literaturlexika und literaturgeschichtlichen Handbüchern Nr. 357-373 4. Rezensionen in Tages- und Wochenzeitungen, Zeitschriften und Rundfunksendungen die autobiographie des albert einstein Nr. 374-382 Der Ausbruch des Ersten Weltkriegs und andere Romane Nr. 383-388 Der Wille zur Krankheit Nr. 389-395 Lichtenberg Nr. 396-406 Herr Mantel und Herr Hemd Nr. 407-412 Der große Horizont Nr. 413-435 Ein neuer Morgen Nr. 436-455 Sehnsucht (Graz) Nr. 456-478 Sehnsucht (Basel) Nr. 479-490 Sehnsucht (Wien) Nr. 491-492 Sehnsucht (Berlin) Nr. 493-500 Sehnsucht (Saarbrücken) Nr. 501 Winterreise Nr. 502-535 Dämmerung Nr. 536-547 Menschen, Bilder, Marionetten - Prosa, Kurzromane, Stücke Nr. 548-556 Der stille Ozean Nr. 557-589 Bruno Kreisky Nr. 590-596 Circus Saluti Nr. 597-610 On the Boarderline/Grenzland Nr. 611-615 Die schönen Bilder beim Trabrennen Nr. 616 Das Töten des Bussards Nr. 617-619 Landläufiger Tod u. Dorfchronik zum "Landläufigen Tod" Nr. 620-647 Erinnerungen an die Menschheit Nr. 648-688 Am Abgrund Nr. 689-708 Gsellmanns Weltmaschine Nr. 709-711 Franz Lindner und er selber Nr. 712-715 Der Untersuchungsrichter. Die Gechichte eines Entwurfs Nr. 716-731 Über Bienen Nr. 732-737 Im tiefen Österreich Nr. 738-747 Über Bilder. Österreichische Malerei nach 1945 Nr. 748-752 Eine Reise in das Innere von Wien Nr. 753-770 Die Gechichte der Dunkelheit Nr. 771-794 Die Archive des Schweigens Nr. 795-805." In Gerhard Roth: Eine Bibliographie. Werke und Rezeption 1966-1994. Dept. of German, University of Otago, 1995. http://dx.doi.org/10.11157/ogs-vol8id260.

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Conference papers on the topic "666.766 : 546"

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Chelucci, C., H. J. Hassan, R. Guerriero, A. Leonardi, G. Mattia, and C. Peschle. "POLYMORPHIC SITES IN FACTOR X GENE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643836.

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The structure of factor X gene has been analyzed by Southern blot in 5 subjects with factor X deficiency.Genomic DNA was digested with 8 different endonucleases and hybridized with a cDNA probe. The congenital deficiency observed in these patients is not apparently due to a major deletion or rearrangement. Since the gene locus is grossly intact, the disease presumably results from point mutation(s) not identified by the utilized endonucleases.Our study was also focused on the presence of polymorphic site(s) in the factor X gene locus. Analysis of 50 normal subjects allowed to identify several polymorphic restriction sites after digestion with EcoRI, Hind III and Pvu II.The restriction pattern obtained after Hind III digestion showed two bands of 7.3 and 6.0 Kb, while in two families an additional 7.6 Kb band was observed. Genomic DNA digested with EcoRI showed a 7.1 and 5.1 Kb fragments, and also a 6.6 Kb band with a 10% f requency.After DNA digestion with Pvu II 5.6, 2.7 and ∼1.0 Kb bands were observed. In three unrelated subjects we observed an additional 3.0 Kb fragment, in two other subjects a 3.5 kb band. Interestingly hybridization with a 178 bp cDNA subclone allowed to map the polymorphic sites in a the 3’ region of the gene locus.
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Dobyns, Alan L. "Application of Composites in Helicopter Design at Sikorsky Aircraft." In ASME 1998 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1998. http://dx.doi.org/10.1115/imece1998-0389.

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Abstract The history of advanced composites usage at Sikorsky will be discussed, starting with small components in the 1970s up to the present where the structure of the RAH-66 Comanche helicopter is constructed almost entirely of composites. One of the initial composite components developed in the 1970’s was a reinforcing Boron strap for the tail of the UH-54 Skycrane. In the 1980’s the UH-60 Blackhawk and the S-76 production aircraft employed a graphite/epoxy tail rotor flexbeam. In addition a composite rear fuselage was developed for the UH-60 Blackhawk, and an all composite research helicopter was built under Army contract to develop composites technology (the S-75 ACAP). Also, graphite/epoxy composite fuel sponsons were put into production for the MH-53E Super Stallion. In the 1990’s the RAH-66 Comanche attack helicopter was developed, utilizing a graphite/epoxy-honeycomb primary structure. The S-92 Helibus commercial helicopter uses graphite/epoxy fuel sponsons, tail rotor flexbeams, and numerous fairings.
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Giannessi, D., R. De Caterina, G. Lazzerini, R. Sicari, and P. Gazzetti. "RELATIVE SENSITIVITY OF CARDIAC PROSTACYCLIN AND THROMBOXANE TO INHIBITION BY NON-STEROIDAL ANTIINFLAMMATORY DRUGS IN THE RAT HEART." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643390.

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We have previously shown that the isolated perfused rat Langendorff heart is able to synthesize detectable amounts of thromboxane (TX) A2, as well as prostacyclin (PGI2). Eicosanoid production in this system is increased during post-ischemic reperfusion, reflecting greater availability of substrate and net increase of synthesis. We assessed relative sensitivity of cyclooxygenases synthesizing TX and prostacyclin (probably located in different cell types) to aspirin (0.1, 0.5, 1 g/1), ibuprofen (1, 10, 80, 160, 320 mg/1) and diclofenac (0.01, 0.1, 0.5, 2.5, 5, 10, 25 mg/1), by radioimmunoassays of TXB2 and 6-keto-PGFα in the perfusate. Sixty Wistar male rat hearts were perfused with buffer containing control vehicle or drugs for 30 min, followed by 5 min clamping of the perfusion line and subsequent post-ischemic reperfusion. Baseline production was (mean±SD, pg/min/g wet weight) 754±261 and 143±66 for PGI2 and TXA2, respectively. Peak post-ischemic production was 7628±2673 and 1036±135, respectively. At doses of aspirin, ibuprofen and diclofenac (100, 10 and 2.5 mg/1, respectively) which were equally effective on prostacyclin production (mean % inhibition: 68, 67 and 72 for basal production and 90, 86 and 85 for peak post-ischemic production, respectively), % inhibition of TX production was consistently less, but also similar for the three drugs: 55, 58 and 56 for basal production and 78, 81 and 76 for peak post-ischemic production, for aspirin, ibuprofen and diclofenac, respectively; difference between inhibition of prostacyclin and TX: P < .01, difference for subsets among different drugs: N.S.). TX production was, on the contrary, selectively inhibited by the TX-synthase inhibitor 0KY 046 (by 79 and 92% at 0.1 mg/1, versus a complete sparing of prostacyclin production). The lesser sensitivity of cardiac (vascular?) TX versus prostacyclin to non-steroidal antiinflammatory drugs (NSAIDs) inhibition and the similar degree of inhibition by various NSAIDs, differing in structure and diffusing capacity, suggest heterogeneity among cyclooxygenases present in the system and different intrinsic sensitivity of TX- from prostacyclin-producing cyclooxygenases.
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4

Woods, A. I., and M. A. Lazzari. "ASPIRIN FAILURE TO INHIBIT THE RELEASE OF PLASMINOGEN ACTIVATORS-INHIBITORS BY HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643126.

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Abstract:
Platelet-PA-Inhibitors can be released by thrombin, Col laaen( Col) and others.If they are physiologically important,inhibition of their release might facilitate thrombolysis.Intrinsic PA were tested in euclobulins (eug)of PPP and PPP+Washed platelets(WP) ,with and without aspirinf ASA) .treated with UK,SK and Col(20 atfd l2uo/ml) Results(mm2)were:euaPPP:232+78;+3×106WP/ul:217+71;+10%7ul:188+/5 +2×106MP/ul: 157+69:With UK:eugPPP:283+76;+3×l0517P/ul :234+69;+106 WP/ul :172+55;+2×l(PWP/ul :154+48; With SK:euoPPP:303+99;+3×l05WP/ul 252+65;+1067P/ul:203+68;+2×106UP/ul: 174+85;Wi th Col (20ug/ml) :eur PPP:234+97;+3×105WP/ul:160+63;+106WP/ul:141+73;+2×l06WP/ul:129+81; +2×106WP/ul+ASA: 105+31;Wi th Col uc/ml) :euaPPP:230+56;+3×l05NP/ul: 160+52;+106WP/ul:139+44;+2×106wp/ul:126+21;+2×106WP/ul+ASA:118+28. EugPPP+l/P showed lower lysis area.Col induced more decrease of lysis area in euc with WP.ASA did not modify this effect.UK and SK produced higher lysis area only in euoPPP.No difference was observed between high and low doses of Col-effect upon WP.Combined treatment of eucPPP+WP+Col, with UK and SK showed:(mm2):UK-treated eugPPP+2×106WP/ul+Col(29ug/ml):134+25;+ASA and Col(20ug/ml):115+65;+Col(2uc/ml):157+50;+ASA and Col(2uo/ml):133+49; SK-treated eupPPP+2×106WP/ul:+Col(20uo/ml):144+49;+ASA and Col(20ug/ml):128+ 60;+Co1(2ug/ml):173+66;+ASA and Col(2ug/ml):142+36.Col (20ug/ml) produced slight lower lysis area of UK and SK-treated eugPPP+WP. (p:ns). ASA did not modify this effect.Col (2uc/ml) did not produce changes in lysis area of UK and SK-treated eupPPP +WP. ASA produced slight lower lysis area(p:ns).Conclusion: high dosis of Col could release anti UK,anti SK and intrinsic PA-inhibitors from platelets;low dosis of Col could only release fntrinsic PA-inhibi tors. It suggests that anti UK and anti SK release might be triggered by stronger stimuli than intrinsic PA inhibitors.ASA could not inhibit any inhibitors release.We must consider that PA-inhibi tors could be released by different metabolic pathways other than cyclooxygenase pathway.
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