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Lee, M. R., M. Quartern, and S. Jaulmes. "New Crystal Data for Seven Molybdates MIIUMo4O16 (MII = Mg,Mn,Cd,Ca,Hg,Sr,Pb)." Powder Diffraction 3, no. 2 (June 1988): 106–9. http://dx.doi.org/10.1017/s0885715600013361.
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AbstractSeven isotopic molybdates MIIUMo4O16 have been synthesized by solid state reaction with MII = Mg, Mn, Cd, Ca, Hg, Sr, Pb. Single crystals of CaUMo4O16 were obtained. Previously reported as triclinic, this compound is monoclinic, space group P2/n. Unit-cell parameters for the seven compounds are:MgUMo4O16: a = 11.393(2), b = 6.505(1), c = 7.918(2) Å, β = 89.81(3)°, V = 586.8(5) Å3, Z = 2, Dx = 5.12 Mg m−3;MnUMo4O16: a = 11.413(2), b = 6.555(1), c = 8.023(1) Å, β = 89.86(2)°, V = 600.2(4)Å3, Z = 2, Dx = 5.18 Mg m−3;CdUMo4O16: a = 11.427(2), b = 6.607(1), c = 8.144(2) Å3, β = 90.40(2)°, V = 614.8(5)Å3, Z = 2, Dx = 5.37 Mg m−3;CaUMo4O16: a = 11.443(3), b = 6.653(2), c = 8.239(2)Å, β = 90.51(3)°, V = 627.2(6)Å3, Z = 2, Dm = 4.83(5), Dx = 4.88 Mg m−3;HgUMo4O16: a = 11.439(3), b = 6.643(1), c = 8.257(2)Å, β = 90.53(3)°, V = 627.4(6)Å3, Z = 2, Dx = 5.73 Mg m−3;SrUMo4O16: 11.465(3), b = 6.768(2), c = 8.492(2) Å, β = 90.86(3)°, V = 658.8(6)Å3, Z = 2, Dx = 4.88 Mg m−3;PbUMo4O16: a = 11.470(4), b = 6.813(2), c = 8.557(2)Å, β = 90.88(4)°, V = 668.7(8)Å3, Dx = 5.41 Mg m−3;Powder diffraction data for each phase are reported.
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McLoughlin, Shauna L., Richard A. D. Pattrick, J. Frederick W. Mosselmans, Joe Kelleher, and Bart E. van Dongen. "Selenium Uptake from Livestock Pasture Extremely Enriched in Selenium, Molybdenum and Uranium: A Field and X-ray Absorption Study." Soil Systems 7, no. 1 (March 10, 2023): 24. http://dx.doi.org/10.3390/soilsystems7010024.
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The agricultural soils of West Limerick, Ireland, contain very localised, extremely high natural Se concentrations that reach levels that are very toxic to grazing livestock. The Carboniferous shales that formed in anoxic deep-water marine environments are the source of the selenium, which, along with the other redox-sensitive elements of molybdenum, uranium, arsenic and vanadium, were mobilised and reprecipitated in post-glacial anoxic marshes. The result has been a history of selenosis and molybdenosis in livestock in this important dairy province. Soils collected at 10–20 cm from five different agricultural sites were analysed, and all yielded concentrations greatly in excess of the safe Se limits of 3–10 mg kg−1; the highest value recorded was 1265.8 mg kg−1 Se. The highest recorded value for Mo in these soils was 1627.5 mg kg−1, and for U, 658.8 mg kg−1. There was a positive correlation between Se, Mo U and organic matter in the soils. Analysis of non-accumulator pasture grasses (Lolium perenne (perennial ryegrass), Festuca arundinacea (tall fescue), Dactylis glomerata (cocksfoot) and Phleum pretense (timothy grass)) revealed the shoot/leaf to contain up to 78.05 mg kg−1 Se while Trifolium repens (white clover) leaves contained 296.15 mg kg−1 Se. An in situ growing experiment using the Se accumulator species Brassica oleracea revealed 971.2 mg kg−1 Se in the leaves of premier kale, which also contained 1000.4 mg kg−1 Mo. Translocation factors (TFs) were generally higher for Mo than Se across all plant species. Combined X-ray absorption near edge spectroscopy (XANES) with micro-X-ray fluorescence (μ-XRF) showed the Se was present in the soil predominantly as the reduced immobile phase, elemental Se (Se0), but also as bioavailable organoselenium species, mainly selenomethionine (SeMet). SeMet was also the main species identified within both the Se non-accumulator and Se accumulator plants. The Se soil–plant system in West Limerick is dominated by SeMet, and uptake into the cattle pasture results in selenosis in the grazing dairy herds. The hyperaccumulating Brassica oleracea species could be used to extract both the Se and Mo to reduce the toxicity of the blighted fields.
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Blake, Cody, Jason Street, James Wooten, Brian Mitchell, and Frank C. Owens. "Industrial-scale Pelletization of Southern Pine Energy Pellets with Various Additives." Applied Engineering in Agriculture 35, no. 6 (2019): 889–901. http://dx.doi.org/10.13031/aea.13382.
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Abstract. The energy pellet industry desires to improve processing techniques and the characteristics of fuel pellets by including additives with the feedstock. In this study, the industrial-scale pelletization of southern yellow pine (SYP) planer shavings was performed along with experiments involving the effect of production rate and moisture on the energy required for production (measured in kWh Mg-1). Multiple additives were investigated to determine their effects on southern yellow pine pelletization performance and pellet characteristics. These additives included southern-yellow-pine-derived biochar (BC), southern-yellow-pine-derived bio-oil (BO), corn starch (CS), vegetable oil (VO), sweet potatoes (SwP), microcrystalline cellulose (MCC), micronized rubber powder (MRP), and mixed hardwood planer shavings (HW). A control was compared to 20 different treatments at various additive concentrations, and the effect on pellet durability, bulk density, and higher heating value was determined. The production rate of the pellets with additives varied but were able to be compared with the baseline regression line (production rate vs. energy required for production per Mg) control trials so that the appropriate amount of energy required to produce one Mg of biomass could be compared to the control. The data for the additives, which outperformed the control using the economic study, are listed below. The control, HW10%, HW 25%, HW 50%, BC 0.5%, BC 1%, BC 2%, BC 4%, MRP 1%, and BO 0.5% had a mean pellet durability index (PDI) of 97.9%, 98.1%, 98.1%, 97.7%, 98.2%, 98.6%, 98.4%, 98.7%, 98.0%, and 98.0%, respectively. The control, HW10%, HW 25%, HW 50%, BC 0.5%, BC 1%, BC 2%, BC 4%, MRP 1%, and BO 0.5% had mean bulk density values of 703.0, 700.8, 704.8, 692.2, 693.9, 695.6, 695.6, 683.2, 658.8, and 684.6 kg m-3, respectively. The mean higher heating values (HHV) for the control, HW10%, HW 25%, HW 50%, BC 0.5%, BC 1%, BC 2%, BC 4%, MRP 1%, and BO 0.5% were 19.0, 18.9, 18.6, 18.2, 19.4, 19.5, 19.6, 19.6, 19.6, and 19.2, MJ kg-1, respectively. The normalized energy requirements for production for the control, HW10%, HW 25%, HW 50%, BC 0.5%, BC 1%, BC 2%, BC 4%, MRP 1%, and BO 0.5% were 112.0, 110.5, 112.1, 115.3, 110.7, 111.7, 112.1, 118.1, 108.5, and 111.1 kWh Mg-1, respectively. An economic feasibility analysis showed that the discounted net present value (NPV) at a rate of 12% could be improved when using certain pellet additives in the feedstock. The following additives could increase the profit of the mill over just using the control: hardwood planer shavings at 10%, 25%, and 50%, biochar at 0.5%, 1%, 2%, and 4%, MRP at 1% and bio-oil (with volatiles removed) at 0.5% (all on a dry basis). Keywords: Biochar, Biomass pellets, Bio-oil, Corn starch, Hardwood, Micronized rubber powder, Microcrystalline cellulose, Sweet potato, Vegetable oil.
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Buschmann, Rolf, and Hans-Uwe Schuster. "Notizen: Darstellung und Kristallstruktur der Verbindung LiCo6P4 / Synthesis and Crystal Structure of the Compound LiCo6P4." Zeitschrift für Naturforschung B 46, no. 5 (May 1, 1991): 699–702. http://dx.doi.org/10.1515/znb-1991-0525.
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A new compound LiCo6P4 could be synthesized, it crystallizes in the hexagonal space group P6̅m2 with the lattice constants a = 658.4(3) pm, c = 333.8(2) pm, c/a = 0.507. The structure shows close relations to the Fe2P- or Zr2Fe12P7-type structures.
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Zhong, Xuan, Xian Tao Tong, Mu Huo Yu, Hai Feng Li, Huan Li, Xin Da Li, Magdi E. Gibril, Yue Zhang, and Ke Qing Han. "Graft Polymerization of L-Lactide onto Cellulose in Ionic Liquid via Twin Screw Extruder." Advanced Materials Research 658 (January 2013): 8–12. http://dx.doi.org/10.4028/www.scientific.net/amr.658.8.
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A twin-screw extruder was used to carry out the ring opening graft polymerization of L-lactide onto cellulose through reactive extrusion process. Ionic liquid (1-butyl-3-methylimidazolium chloride) [Bmim]Cl and Sn(oct)2 were used as solvent and catalyst, respectively. FTIR, TGA and XRD were used to investigate the structure, thermal stability and crystalline behavior of the reaction products. The result showed a successful ring opening polymerization of L-lactide on cellulose. Furthermore, it showed a increased crystalline degree and thermal stability after being introduced the PLLA.
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Merzweiler, Kurt, and Hans-Jörg Kersten. "Notizen: Darstellung und Kristallstruktur von [{(CO)5WPhP}2S2] / Synthesis and Crystal Structure of [{(CO)5WPhP}2S2]." Zeitschrift für Naturforschung B 48, no. 4 (April 1, 1993): 541–44. http://dx.doi.org/10.1515/znb-1993-0422.
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The reaction of [{(CO)5W}PhPCl2] with S(SiMe3)2 leads to the formation of [{(CO)5WPhP}2S2] (1). 1 crystallizes in the space group P21/n. The lattice constants (at 298 K) are: a = 658.9(3), b = 2287.6(11), c = 1905.5(9) pm, β = 94.53(3)°. According to the crystal structure determination 1 contains a four-membered P2S2 ring which is coordinated to two {(CO)5W} units.
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Rohman, Fikri Habibur, Julio Sukamto, Robi Mohammad Arifin, and Muhammad Farhan Alfiansyah. "Pengembangan Masyarakat melalui Penetapan dan Penegasan Batas di Desa Ledokombo Kabupaten Jember." Jurnal Al-Tatwir 9, no. 2 (October 1, 2022): 101–12. http://dx.doi.org/10.35719/altatwir.v9i2.57.
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Ledokombo Village is a village which is located in Ledokombo District, Jember Regency. Ledokombo Village is a village that has 3 Krajan Hamlets, Sumber Nangka Hamlet, and Krajan Hamlet. Lodokombo Village itself has an area limit of 658.5 hectares. Lodokombo District has several villages and one of them is Ledokombo Village, and this Ledokombo Village there must be a re-emphasis on the boundary between Ledokombo Village and other villages. The emphasis here is not only oriented to village boundaries but also to Dusun boundaries, the emphasis here is also a manifestation of increasing awareness of village and hamlet boundaries for the people of Ledokombo Village. Our service is nothing but the aim of preventing conflicts between village boundaries and hamlets in Lodokombo Village. The determination and affirmation of village boundaries has an important and positive impact on the community as stated in Permendagri Number 27 of 2006. So the substance can be seen how important village boundaries are to clarify or reinforce village boundaries with one another
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Rivera, José María, Susana Rincón, Cherif Ben Youssef, and Alejandro Zepeda. "Highly Efficient Adsorption of Aqueous Pb(II) with Mesoporous Metal-Organic Framework-5: An Equilibrium and Kinetic Study." Journal of Nanomaterials 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/8095737.
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Mesoporous metal-organic framework-5 (MOF-5), with the composition Zn4O(BDC)3, showed a high capacity for the adsorptive removal of Pb(II) from 100% aqueous media. After the adsorption process, changes in both morphology and composition were detected using a scanning electron microscope (SEM) equipped with an energy dispersive X-ray (EDX) system, Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS) analysis. The experimental evidence showed that Zn(II) liberation from MOF-5 structure was provoked by the water effect demonstrating that Pb(II) removal is not due to ionic exchange with Zn. A kinetic study showed that Pb(II) removal was carried out in 30 min with a behavior of pseudo-second-order kinetic model. The experimental data on Pb(II) adsorption were adequately fit by both the Langmuir and BET isotherm models with maximum adsorption capacities of 658.5 and 412.7 mg/g, respectively, at pH 5 and 45°C. The results of this work demonstrate that the use of MOF-5 has great potential for applications in environmental protection, especially regarding the removal of the lead present in industrial wastewaters and tap waters.
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Vakhrushev, Y. M., and M. S. Busygina. "State of enteral parallel microbiota in chronic duodenal insuffi ciency." Experimental and Clinical Gastroenterology, no. 12 (January 14, 2022): 21–27. http://dx.doi.org/10.31146/1682-8658-ecg-196-12-21-27.
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Objective. To study the state of the enteral parietal microbiota and to assess the conjugacy of its changes with motor-evacuation disorder of the gastrointestinal tract (gastrointestinal tract) in chronic duodenal insufficiency.Materials and methods. The study included 40 patients with chronic duodenal insufficiency (CDN). Of these, 21 (52.5%) were women, 19 (47.5%) were men, the average age was 37.1± 13.8 years. CDN was diagnosed using anamnestic and physical data, X-ray and endoscopic examinations, intracavitary manometry. Enzyme immunoassay determined vitamin B12, 25-OH Vitamin D, transferrin. The study of the motor function of the gastrointestinal tract was carried out using the gastroenteromonitor “Gastroscan-GEM”. The method of gas chromatography with mass spectrometry was used to study the enteral wall microbiota.The results of the study. The blood showed a decrease in fat-soluble vitamins B12 and 25-OH vitamin D in relation to control. There was a decrease in the transferrin saturation coefficient (13.2%) compared to the control group (34.7%, p=0.04). Gastroenteromonitoring on the device “Gastroscan-GEM” showed a decrease in the coefficients of rhythmicity in the stomach and DPC in the fasting and postprandial periods. Chromass spectrometric analysis of resident microflora in patients with CDN revealed a significant decrease in Lactobacillus spp 1245.3± 0.21 cl/g x 10^3 and Bifidobacterium spp 1453.2± 0.18cl/g x 10^3 against the background of pronounced growth of bacteria of the genus Clostridium, Eggerthella lenta 412.3± 0.84cl/g x 10^3, Propionibacterium acnes 58.6± 0.32cl /g x 10^3, Propionibacterium freudenreichii 2388.7± 0.62 cl/g x 10^3, Propionibacterium jenseni 146.6±0.32 cl/g x 10^3, Staphylococcus spp 658.4± 0.28 cl/g x 10^3, Streptococcus mutans (anaerobic) 494.3±0.74 cl/g x 10^3, Streptomyces spp. 305.3±0.26 cl/g x 10^3. It was shown that the increased growth of pathogenic microflora was associated with a violation of the rhythm of duodenal motility.Conclusion. In patients with chronic duodenal insufficiency, a pronounced growth of parietal pathogenic microflora was detected, depending on the state of motor activity of the duodenum.
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Dinh, Văn Chien, Thanh Phu Nguyen, Thanh Hoa Doan, and Van Khoa Bui. "Optimizating Spray Parameters of High Velocity Oxy Fuel (HVOF) for Cr3C2 - NiCr Coating." Applied Mechanics and Materials 889 (March 2019): 168–76. http://dx.doi.org/10.4028/www.scientific.net/amm.889.168.
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Porosity, hardness, and adhesion mainly affect the performance of thermal spray coating and significantly depend on spray parameters. Therefore, determining value of the spray parameters and their effects on the coating properties are always taken into consideration. This paper studies optimization as well as evaluates influences of HVOF spray parameters which include powder feed rate (M), rotational speed of the details per minute (N) and step movement of the nozzle per revolution (S) to the adhesion, porosity, micro-hardness of Cr3C2 - 20(80Ni20Cr) coating on 40Cr steel shaft substrate. Taguchi experimental design L9 combined with analysis of variance (ANOVA) was used to determine optimum spray parameters and percentage of effect of each spray parameter on properties of the coating. From obtained results, the optimal spray parameters are m = 35 g.min-1, n = 130 rpm, S = 6 mm for the highest hardness coating of 658.2 HV; with m = 45g.min-1, n = 130rpm, S = 3 mm for the smallest porosity of 1.27%; with m = 35g.min-1, n = 130 rpm, S = 3 mm for the coating with a maximum adhesion of 44.07 MPa. The percent effects of the parameters m, n, S to adhesion, porosity and hardness were (2.8%, 33.6%, 63.6%), (0.1%, 1.3%, 98.6%), (32.7%, 43.3%, 24%), respectively. The percent effects of spray parameters on corresponding coating property allows adjustment of spray parameters to obtain the desired coating. Verified experiment results shows that the results are reliable. Taguchi method and ANOVA can find optimal parameters of the HVOF spray to acquire high-performance coating.
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Emmerling, Franziska, and Caroline Röhr. "Alkalimetall-Arsenide A3As7 Und Aas (A = K, Rb, Cs). Synthesen, Kristallstrukturen, Schwingungsspektren / Alkaline Metal Arsenides A3As7 and AAs (A = K, Rb, Cs). Preparation, Crystal Structure, Vibrational Spectroscopy." Zeitschrift für Naturforschung B 57, no. 9 (September 1, 2002): 963–75. http://dx.doi.org/10.1515/znb-2002-0901.
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The title compounds were synthesized from the elements and characterized via single crystal x-ray studies and Raman spectroscopy. In the Zintl phases A3As7 (A = K, Rb, Cs) the As atoms form nortricyclene-analogous anions As37 with As-As distances ranging from 230 to 254 pm. The three compounds crystallizewithdifferent newstructure types containing different packings of theAs7 anions:K3As7 (orthorhombic, Pbca; a=1291.9(8), b = 2544.1(9), c=1537.7(16) pm) shows a double hexagonal close packing (ABAC stacking of planes of hexagonal close packed anions), Rb3 As7 (monoclinic, P21/c, a = 757.3(5), b = 1310.2(8), c = 2692.7(18) pm , β= 91.972(12)°) hows a hexagonal close packing (AB) and the Cs compound (orthorhombic, Pbca, a = 1022.8(5), b = 1317.6(7), c = 2195.2(11) pm) a cubic close packing (ABC) (also present in theHT-forms of the three compounds) respectively. The alkaline metalmonoarsenides AAs (A = K, Rb) crystallize with the NaP structure type (A = K/Rb: orthorhombic, P212121; a = 661.7(5) / 658.1(8), b = 688.8(6) / 691.6(8), c = 1197.3(10) / 1204.7(10) pm, Z = 8) with approximate fourfold screw axes 41 of As$ chains, whereas the crystal structure of CsAs (hexagonal, P¯62m, a = 1219.7(3), c = 1046.3(2) pm, Z = 18) contains three crystallographically independent three membered rings As33 with As-As distances of 243.0 to 247.5 pm
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Ghimire, Binod, Shiva Chandra Dhakal, Santosh Marahatta, and Ram Chandra Bastakoti. "Yield and Cost Benefit Assessment of Lentil (Lens culunaris) Differentiated by Scale, Method and Purpose of Production in Nepal." International Journal of Social Sciences and Management 10, no. 3 (July 31, 2023): 60–65. http://dx.doi.org/10.3126/ijssm.v10i3.57135.
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Diverse production system and cultivation methods are followed for lentil crop in Nepal. This study was designed to analyze differentiated yield and cost benefit analysis of lentil by scale, method and purpose of production. Four major lentil producing districts in Nepal was purposively selected and followed multistage sampling. Face-to-face interview method was applied with randomly selected 473 respondents using pre-tested semi-structured interview schedule for primary data collection in 2022. Descriptive statistics, comparative yield analysis, benefit cost analysis methods were adopted and analyzed using MS-excel and STATA software. The average yield (kg/hac.) of lentil was 672.6 in the study area. Yield analysis resulted higher yield with the seed producer (739.1 kg/ha.) followed by improved seed user (706.3 kg/ha.), small scale farms (690.1 kg/ha.), commercial scale farms (658.0 kg./ha.), local seed user and grain producer (652.9 and 653.4 mt/ha.). Again, benefit cost ratio was higher among the seed producer (2.02) indicating lentil seed producing as a higher profitable enterprise followed by improved seed user (1.88), commercial farms (1.79), small scale farms (1.77) and grain producers (1.71). It can be concluded that lentil farming with a purpose of producing seed by the use of improved varietal seed in a commercial scale with good management practices is highly profitable. Int. J. Soc. Sc. Manage. Vol. 10, Issue-3: 60-65
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Tan, Nguyen Duy Ngoc, Nguyen Ho Lam, Tran Minh Duc, Nguyen Van Loi, Pham Thanh, Ngo Tung Duc, Dinh Tien Tai, and Nguyen Ngoc Thanh. "Influence of environmental factors on habitat of <em>Jasminum subtriplinerve</em> in Central Vietnam." Multidisciplinary Science Journal 6, no. 10 (May 3, 2024): 2024192. http://dx.doi.org/10.31893/multiscience.2024192.
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Jasminum subtriplinerve, a rare and valuable medicinal plant, is facing the problem of habitat loss. This study was conducted to determine the influences of environmental factors on the distribution and identify habitat suitability areas for this species in Central Vietnam. Based on the 19 bioclimatic, 10 soil properties, 3 topographic variables and 86 observed locations, we used Correlation Analysis processing, follow by the Maximum entropy (MaxEnt) algorithm was applied to predict the spatial potential distribution of J. subtriplinerve. Using the MaxEnt model for analyzing the J. subtriplinerve distribution showed a good performance (AUC testing = 0.821 and AUC training = 0.887). The most influential factors on J. subtriplinerve distribution were Altitude (49.2%), Mean diurnal range (10.6%), Isothermality (6.9%), Bulk density (5.2%), Normalized difference vegetation index (4.7%) and Proportion of sand particles (4.6%). In addition, the model showed that very high and high potential habitat areas of J. subtriplinerve occupied 3.17% (658.88 km2) and 8.95% (1,858.56 km2) of the studied site, distributed in the midland and low mountainous areas, the most suitable Altitude ranged from 8.1 to 138.7 m. Meanwhile, 15.17%, 18.10% and 54.60% of the studied site were nominated as moderate (3,148.93 km2) low (3,758.10 km2), and very low (11,334.17 km2) potential habitat areas, respectively. This study comprehensively evaluated factors affecting habitat suitability, therefore, these results provide an understanding of the bioecological distribution of J. subtriplinerve guiding the identification of optimal areas for cultivation and conservation.
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Sosa-Montes, E., U. Martínez-Martínez, A. Pro-Martínez, F. González-Cerón, J. Gallegos-Sánchez, and L. T. Rodríguez-Ortega. "Nutritive value of full-fat dehulled sunflower seeds in diets for broiler chickens." South African Journal of Animal Science 51, no. 4 (September 16, 2021): 542–49. http://dx.doi.org/10.4314/sajas.v51i4.15.
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The goal of this research was to evaluate the nutritive value of full-fat de-hulled sunflower seeds (DHSS) in feeding broiler chickens. Three experiments were conducted. Experiment 1 determined the proximal analysis of DHSS, the essential amino acid content, and apparent metabolizable energy (AME). In experiment 2, two diets were formulated, namely a control and a diet containing 10% DHSS. Apparent ileal digestibility (AID) of dry matter (DM), crude protein (CP), and ether extract (EE) were calculated. In experiment 3, the performances of broilers fed the two diets were evaluated in terms of the relative weights of digestive system organs, breast meat colour, growth and feed consumption. Full-fat de-hulled sunflower seeds were characterized as having 507.9 g/kg EE, 282.1 g/kg CP, 21.02 MJ/kg AME and 9.3 g/16 g N arginine. Apparent ileal digestibility of DM in the 10% DHSS diet was 658.0 g/kg, similar to that of the control diet (643.0 g/kg). Partial substitution of DHSS for soybean meal (SBM) did not affect the relative weight of digestive system organs, except for the liver. The relative weights of the liver were 17.90 g/kg bodyweight in birds fed the DHSS diet and 16.37 g/kg bodyweight (P <0.05) in the control. The colour of the breast meat was 3.5% darker and 13.8% less yellow for DHSS birds compared with the control. Growth and feed consumption were unaffected by the dietary treatments. Therefore, 10% DHSS can partially replace SBM in broiler finisher diets.
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De Gregorio, Miguel Ángel, Masao Yamamoto-Ramos, Arturo Fredes, Carolina Serrano-Casorran, Sergio Sierre, Juan José Ciampi-Dopazo, Santiago Méndez, et al. "A Comparative Study of a Small Series of Patients (50 Patients) with Pelvic Varicose Veins Treated with Plugs Alone or Plugs and Polidocanol." Journal of Clinical Medicine 12, no. 16 (August 20, 2023): 5408. http://dx.doi.org/10.3390/jcm12165408.
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Level of Evidence: Level 2. Purpose: To compare the safety and efficacy of vascular plug (VP) and vascular plug and polidocanol foam (VPPF) treatments for embolization in pelvic congestion syndrome (PCS). Materials and methods: A comparative, prospective, two-center study enrolled 50 women with PCS from January 2019 to January 2020. The patients were divided into two groups, and embolization was performed with VP (n = 25) and VPPF (n = 25) treatments. The mean age of the patients was 45.6 years ± 6.9. Three clinical parameters were assessed: abdominal pain, dyspareunia, and lower limb pain. The primary outcome (clinical success at 1 yr using a VAS), number of devices, procedure and fluoroscopy times, radiation doses, costs, and complications were compared. The participants were followed-up at 1, 3, 6, and 12 months. Results: At the 1-year follow-up, clinical success did not significantly differ between the two groups (VP vs. VPPF) regarding the improvement of the symptoms analyzed (pelvic pain, dyspareunia, lower extremity pain, and other symptoms (p < 0.05)). The mean number of devices per case was 4 ± 1.1 for the VP group and 2 ± 0.31 for the VPPF group (p < 0.001). No major complications were recorded in either group. The VPPF group had a significantly longer fluoroscopy time (42.8 min ± 14.2 vs. 25.4 min ± 7) and longer radiation dose (VPPF air kerma 839.4 ± 513 vs. VP air kerma 658.4 mGy ± 355 (all p < 0.001)). Conclusions: Embolization for PCS resulted in pain relief in 90% of patients; the use of polidocanol did not demonstrate changes in the clinical outcome. The use of a VP alone was associated with decreased fluoroscopy time and radiation dose.
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Sivaganesh, Vignesh, and Bela Peethambaran. "Receptor tyrosine kinase-like orphan receptor 1 inhibitor strictinin exhibits anti-cancer properties against highly aggressive androgen-independent prostate cancer." Exploration of Targeted Anti-tumor Therapy 4, no. 6 (December 20, 2023): 1188–209. http://dx.doi.org/10.37349/etat.2023.00192.
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Aim: It is important to identify anti-cancer compounds that can inhibit specific molecular targets to eradicate androgen-receptor negative (ARneg), androgen-independent (AI) prostate cancer, which is an aggressive form of prostate cancer with limited treatment options. The goal of this study was to selectively target prostate cancer cells that have high levels of oncogenic protein Receptor tyrosine kinase-like orphan receptor 1 (ROR1) by using strictinin, a small molecule ROR1 inhibitor. Methods: The methods performed in this study include western blots, methyl thiazolyl tetrazolium (MTT) proliferation assays, phosphatidylserine apoptosis assays, apoptosis flow cytometry (Annexin V, caspase 3/7), migration scratch assays, Boyden chamber invasion assays, and cell cycle flow cytometry. Results: Strictinin was most lethal against PC3 [half-maximal drug inhibitory concentration (IC50) of 277.2 µmol/L], an ARneg-AI cell type that expresses the highest levels of ROR1. Strictinin inhibited ROR1 expression, downstream phosphatidylinositol 3-kinase (PI3K)-protein kinase B (AKT)-glycogen synthase kinase 3beta (GSK3β) pro-survival signaling, and epithelial-to-mesenchymal transition markers in PC3 cells. Additionally, strictinin decreased PC3 cell migration and invasion, while increasing S-phase cell cycle arrest. In ARneg-AI DU145 cells, strictinin inhibited ROR1 expression and modulated downstream AKT-GSK3β signaling. Furthermore, strictinin exhibited anti-migratory, anti-invasive, but minimal pro-apoptotic effects in DU145 cells likely due to DU145 having less ROR1 expression in comparison to PC3 cells. Throughout the study, strictinin minimally impacted the phenotype of normal prostatic epithelial cells RWPE-1 (IC50 of 658.5 µmol/L). Strictinin was further identified as synergistic with docetaxel [combination index (CI) = 0.311] and the combination therapy was found to reduce the IC50 of strictinin to 38.71 µmol/L in PC3 cells. Conclusions: ROR1 is an emerging molecular target that can be utilized for treating prostate cancer. The data from this study establishes strictinin as a potential therapeutic agent that targets ARneg-AI prostate cancer with elevated ROR1 expression to reduce the migration, invasion, cell cycle progression, and survival of prostate cancer.
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Casper, David P., and Ishwary P. Acharya. "220 Evaluating LactoPlan for milk replacer inclusion as a direct fed microbial for neonatal calves." Journal of Animal Science 98, Supplement_4 (November 3, 2020): 147–48. http://dx.doi.org/10.1093/jas/skaa278.269.
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Abstract LactoPlan™ is a direct fed microbial (DFM) produced by a proprietary solid-state fermentation process using an unique strain of lactobacillus plantarum which is shelf and heat-stable. The hypothesis was feeding LP will ease transitioning from milk replacer (MR) to calf starter (CS) by improving gut health, appetite, and minimize health challenges due to pathogens and stress. The objective was to evaluate LP in a MR feeding program. Sixty 2-to-5-d-old Holstein calves were randomly assigned to one of three treatments using a randomized complete block design. Treatments were: 1) Control: No LP fed; 2) LP1: LP fed at 4 g/calf/d; and 3) LP2: LP fed at 8 g/calf/d. Calves were fed at 0630 and 1800 h along with free choice water and 22% CP calf starter (CS). The MR feeding phase was 42 d of the 56 d experiment. Calves fed LP2 gained more (P < 0.05) BW (33.0, 36.9 and 37.7 for Control, LP1, and LP2, respectively) than calves fed Control, with calves fed LP1 being intermediate and similar (P > 0.05). The 0 to 42 d (MR feeding phase) ADG (562.9, 595.9, and 655.7 g/d) and 0 to 56 d ADG (588.6, 658.4, and673.0 g/d were greater (P < 0.05) for calves fed LP2 than calves fed Control, with calves fed LP1 being intermediate and similar (P > 0.05). The 56 d CS intake was similar (P > 0.05) among calves fed all treatments (66.3, 69.0, and 72.5 kg/ 56 d), which resulted in greater feed efficiency (0.50, 0.53, 0.52 kg gain/kg DMI) for calves fed LP1 compared with calves fed Control, with calves fed LP2 being intermediate and similar (P > 0.05). This study demonstrates that feeding neonatal calves LP can increase growth performance and feed efficiency when fed at the appropriate inclusion rates.
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Ravandi, Farhad, Jorgensen L. Jeffrey, Deborah A. Thomas, Susan O'Brien, Elias Jabbour, Gautam Borthakur, Rebecca Garris, et al. "Minimal Residual Disease (MRD) Assessed By Multi-Parameter Flow Cytometry (MFC) Is Highly Predictive of Outcome in Adult Patients with Acute Lymphoblastic Leukemia (ALL)." Blood 124, no. 21 (December 6, 2014): 1079. http://dx.doi.org/10.1182/blood.v124.21.1079.1079.
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Abstract Purpose - Predicting outcome in patients with ALL has been traditionally based on pre-treatment characteristics such as age, white blood cell count (WBC) and cytogenetics. Minimal residual disease is a surrogate to the complex interaction of disease biology and therapy and its role in assigning risk is well-established. Many prior studies in patients with ALL have used molecular markers of MRD with few studies evaluating the role of multi-parameter flow cytometry (MFC) in the adult population. We investigated the predictive value of MRD assessed by MFC among 340 patients with ALL treated between March 2004 and March 2014 using regimens including the hyperCVAD backbone. Methods - Among 340 patients with B-ALL treated in this period 323 (95%) achieved complete remission (CR) or CR without platelet recovery (CRp) and were included in this study. Median age was 52 (Range, 15-84). Median WBC was 9.35 x109/L (Range, 0.4-658.1 x109/L). Cytogenetics were normal in 62 (18%), Philadelphia+ in 146 (43%), 11q23/rearranged MLL in 14 (4%), aneuploid in 45 (13%), hyperdiploid in 29 (9%), hypodiploid in 13 (4%), insufficient metaphases/ not done in 31 (9%). MRD by MFC was assessed with a sensitivity of 0.01%, using a 15-marker, 4-color panel in the first half of the study and subsequently a 6-color panel. Bone marrow specimens for MRD assessment were obtained at the time of achievement of CR and at approximately 3 month intervals thereafter. Results - 260 patients had available samples at CR and 166 (64%) became MRD negative. Achieving MRD negative status at CR was associated with a statistically significant improvement in disease-free survival (P =0.004) and overall survival (P=0.03). 215 patients were evaluated for MRD at approximately 3 months and 201 (93%) became negative. Achieving MRD negative status at approximately 3 months was also associated with a statistically significant improvement in DFS (P=0.002) and OS (P=0.003). 166 patients were evaluated for MRD at approximately 6 months and 160 (96%) became negative. Achieving MRD negative status at approximately 6 months was also associated with a statistically significant improvement in DFS (P<0.0001) and OS (P<0.0001). Figure below demonstrates the DFS and OS by MRD status at CR (Figure 1a and 1b), at 3 months (Figure 2a and 2b), and at 6 months (Figure 3a and 3b) with patients censored at the time of undergoing an allogeneic stem cell transplant or last follow-up. On multivariate analysis including age, WBC at presentation, cytogenetics (standard vs. high risk), and MRD status at CR, 3 months and 6 months, achieving an MRD negative status at CR was an independent predictor of DFS (P<0.05). Conclusion – Achievement of an MRD negative state assessed by MFC is an important predictor of DFS and OS in patients with ALL Figure 1 Figure 1. Figure 2 Figure 2. Figure 3 Figure 3. Disclosures No relevant conflicts of interest to declare.
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Martsevich, S. Yu, Yu V. Lukina, and N. P. Kutishenko. "Pharmacoeconomic Analysis of Therapy with Generic Statin Drugs in Patients with High and Very High Cardiovascular Risk (According to the Study PRIORITY)." Rational Pharmacotherapy in Cardiology 16, no. 5 (November 4, 2020): 693–98. http://dx.doi.org/10.20996/1819-6446-2020-10-16.
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Aim. To perform a pharmacoeconomical assessment of the use of generic statin drugs in patients with high and very high cardiovascular risk (CVR) in real clinical practice based on the data of the study PRIORITY.Material and methods. The PRIORITY study included 298 patients with high (29; 9.7%) and very high (269, 90.3%) CVR. All patients were recommended to take the reproduced drugs of atorvastatin and rosuvastatin in an individually prescribed dose. After 1 month (B1), if the target level of lowdensity lipoprotein cholesterol (LDL-C) was not reached, the statin dose was titrated. After 3 months of follow-up (B3), the hypolipidemic effect of statin therapy was evaluated. 295 people completed the study, 285 patients had the results of the lipid profile. To perform a pharmacoeconomic analysis and evaluate the “cost/effectiveness” ratio, we used the prices of generic statins in one of the online pharmacies. The effectiveness of statins was determined by the LDL-C reduction, as well as by the percentage of achieving the target LDL-C level.Results. At the first stage of the pharmacoeconomic analysis, the criterion for the effectiveness of 3-month lipid-lowering therapy was a decrease in LDL-C level by 1 mmol/l. The median and interquartile range of the ratio “cost/effectiveness” indicator for atorvastatin was 658.2 (431.5; 1257.1) RUB/mmol/l, and for rosuvastatin – 621.0 (390.7; 940.6) RUB/mmol/l (p=0.45). The results of a comparative assessment of the “cost/effectiveness” ratio (with the abovementioned effectiveness indicator) in subgroups of patients with high and very high CVR, with the achievement and nonachievement of the target level of LDL-C, adherent and non-adherent to statins, revealed the economic advantage of statins in groups of adherent patients (p=0.35), high-risk patients (p<0.0001) and individuals who reached the target level of LDL-C (p=0.002) when compared with the corresponding comparison groups. Despite the revealed high effectiveness of rosuvastatin at doses of 20-40 mg/day (assessed by the cost/effectiveness of achieving the target values of LDL-C for specific doses of statins), calculation of the “cost/effectiveness” ratio for each reproduced statin, in general, showed a higher economic effectiveness of atorvastatin.Conclusion. Pharmacoeconomic analysis of therapy with generic statin drugs, performed according to the data of the non-randomized uncontrolled study, allows to justify the economic efficiency and advantages of these drugs in various subgroups of patients who need statin therapy.
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Mikhailova, Elena A., Lili Lin, Zhenbang Hao, Hamdi A. Zurqani, Christopher J. Post, Mark A. Schlautman, and Gregory C. Post. "Land Cover Change and Soil Carbon Regulating Ecosystem Services in the State of South Carolina, USA." Earth 2, no. 4 (September 26, 2021): 674–95. http://dx.doi.org/10.3390/earth2040040.
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Integration of land cover change with soil information is important for valuation of soil carbon (C) regulating ecosystem services (ES) and disservices (ED) and for site-specific land management. The objective of this study was to assess the change in value of regulating ES from soil organic carbon (SOC), soil inorganic carbon (SIC), and total soil carbon (TSC) stocks, based on the concept of the avoided social cost of carbon dioxide (CO2) emissions for the state of South Carolina (SC) in the United States of America (U.S.A.) by soil order (Soil Taxonomy), land cover, and land cover change (National Land Cover Database, NLCD) using information from the State Soil Geographic (STATSGO) and Soil Survey Geographic Database (SSURGO) databases. Classified land cover data for 2001 and 2016 were downloaded from the Multi-Resolution Land Characteristics Consortium (MRLC) website. The total estimated monetary mid-point value for TSC in the state of South Carolina was $124.42B (i.e., $124.42 billion U.S. dollars, where B = billion = 109) with the following monetary distribution in 2016 and percent change in value between 2001 and 2016: barren land ($259.7M, −9%) (i.e., $259.7 million U.S. dollars, where M = million = 106), woody wetlands ($33.8B, −1%), shrub/scrub ($3.9B, +9%), mixed forest ($6.9B, +5%), deciduous forest ($10.6B, −7%), herbaceous ($4.8B, −5%), evergreen forest ($28.6B, +1%), emergent herbaceous wetlands ($6.9B, −3%), hay/pasture ($7.3B, −10%), cultivated crops ($9.9B, 0%), developed, open space ($7.0B, +5%), developed, medium intensity ($978M, +46%), developed, low intensity ($2.9B, +15%), and developed, high intensity ($318M, +39%). The percent change in monetary values was different from percent change in areas because different soil orders have different TSC contents. The percent changes (between 2001 and 2016) both in areas and monetary values varied by soil order and land cover with $1.1B in likely “realized” social cost of C mostly associated with Ultisols ($658.8M). The Midlands region of the state experienced the highest gains in the “high disturbance” classes and corresponding SC-CO2 with over $421M for TSC, $354.6M for SOC, and $66.4M for SIC. Among counties, Horry County ranked first with over $142.2M in SC-CO2 for TSC, followed by Lexington ($103.7M), Richland ($95.3M), Greenville ($81.4M), York ($77.5M), Charleston ($70.7M), Beaufort ($64.1M), Berkeley ($50.9M), Spartanburg ($50.0M), and Aiken ($43.0M) counties. Spatial and temporal analyses of land cover can identify critical locations of soil carbon regulating ecosystem services at risk.
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Cappelli, L., J. Perin, C. Bingham, and A. Shah. "AB1499 TWO DISTINCT SUBSETS OF IMMUNE CHECKPOINT INHIBITOR-INDUCED INFLAMMATORY ARTHRITIS DEFINED BY LATENT CLASS ANALYSIS." Annals of the Rheumatic Diseases 82, Suppl 1 (May 30, 2023): 1979.1–1980. http://dx.doi.org/10.1136/annrheumdis-2023-eular.152.
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BackgroundImmune checkpoint inhibitors (ICI) can lead to immune related adverse events, including inflammatory arthritis (IA). ICI-IA is heterogeneous and can be severe, even persisting after ICI cessation. Understanding the clinical heterogeneity of ICI-IA can guide future studies of pathogenesis and identify relevant groups for clinical trials.ObjectivesTo define clinically relevant subgroups within ICI-IA using a data driven approach and to examine differences between subgroups.MethodsParticipants were >=18 years old, treated with anti-PD-1, anti-PD-L1, and/or anti-CTLA-4 agents alone or in combination, and had ICI-IA diagnosed by a rheumatologist. We used information from the baseline rheumatology visit (patient reported symptoms, physical exam features, physician global arthritis rating, and laboratory studies) to cluster patients with latent class analysis. The Bayesian Information Criteria (BIC) was used to select the number of phenotypes with the lowest BIC. We then compared demographics, cancer type and treatments, and IA treatments and outcomes between the estimated phenotypes. Next, we estimated the association between these features of interest and the likelihood of being in the group with the most severe IA symptoms using logistic regression.ResultsOf the 126 patients with ICI-IA, the majority of participants were female (56%) and white (92%). Most patients had a moderate or high level of disease activity by CDAI; the mean CDAI was 16.98 (SD 10.2). Eighteen variables were used to estimate latent classes. Two distinct phenotypes were indicated by the BIC; 61 patients are estimated to be the first phenotype and 65 the second phenotype. Participants in the second phenotype were more likely to have high baseline levels of patient reported pain, stiffness, and disease activity (Figure 1). There were no significant differences in age, gender, race, ethnicity or marital status between the two phenotype groups. Patients in phenotype 2 were more likely to require steroids as compared to patients in phenotype 1 and were more likely to have persistent IA (table 1). Type of ICI therapy, type of cancer, prior chemotherapy or radiation did not differ between the groups. When adjusted for age, gender, baseline steroid use, these variables remained significantly associated with the second phenotype.ConclusionTwo separate phenotypes of ICI-IA were determined with latent class analysis. Those in the group with more severe features at baseline were more likely to need corticosteroids and to have persistent IA, but there was no association with cancer history or treatment. Future research can interrogate underlying genetic and immunologic differences between groups.Figure 1.Predicted probabilities of features for two estimated phenotypesTable 1.Comparison of cancer features, arthritis treatment, and outcomes between estimated phenotypesPhenotype 1Phenotype 2FeatureNMean (SD) or N(%)NMean (SD) or N(%)pCancer relatedCancer type61650.263Melanoma20 (33%)21 (32%)Lung cancer14 (23%)16 (25%)GU cancer3 (5%)4 (6%)GI cancer5 (8%)12 (18%)Breast3 (5%)3 (5%)SCC7 (11%)1 (2%)Other9 (15%)8 (12%)Cancer Stage59640.64322 (3%)3 (5%)310 (17%)15 (23%)447 (80%)46 (72%)Prior radiation61650.850Yes20 (33%)20 (31%)Prior chemo57631.000Yes30 (53%)34 (54%)ICI class61650.757Ipi2 (3%)2 (3%)Anti-PD138 (62%)40 (62%)Anti-PD-L17 (11%)4 (6%)Combo ipi nivo13 (21%)15 (23%)Other0 (0%)2 (3%)Nivo/relatlimab1 (2%)2 (3%)ICI duration at baseline (months)619.4 (8.7)659.9 (10.0)0.767Inflammatory arthritis relatedSymptom duration at baseline (months)616.3 (7.7)658.0 (10.4)0.304Patient on steroids at baseline61650.544Yes14 (23%)19 (29%)Steroid (any)61650.010Yes47 (77%)61 (94%)Steroid injections in the joint since starting ICI ICIIICIimmunotherapy33360.585Yes7 (21%)10 (28%)Any csDMARd61650.135Yes17 (28%)27 (42%)other2 (12%)0 (0%)Any biologic61640.075Yes8 (13%)17 (27%)Erosions on imaging19270.635Yes3 (16%)2 (7%)Persistent >6 months after ICI stop54600.024Yes37 (69%)52 (87%)REFERENCES:NIL.Acknowledgements:NIL.Disclosure of InterestsLaura Cappelli Grant/research support from: Bristol-Myers Squibb, Jamie Perin: None declared, Clifton Bingham Grant/research support from: Bristol-Myers Squibb, Ami Shah Grant/research support from: Kadmon Corporation, Eicos Sciences, Medpace LLC, Arena Pharmaceuticals.
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Ravandi, Farhad, Susan O'Brien, Rebecca Garris, Stefan H. Faderl, Deborah A. Thomas, Jan A. Burger, Alessandra Ferrajoli, Elias Jabbour, Jorge E. Cortes, and Hagop M. Kantarjian. "Final Report Of Single-Center Study Of Chemotherapy Plus Dasatinib For The Initial Treatment Of Patients With Philadelphia-Chromosome Positive Acute Lymphoblastic Leukemia." Blood 122, no. 21 (November 15, 2013): 3914. http://dx.doi.org/10.1182/blood.v122.21.3914.3914.
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Abstract Background The dual Src and Abl inhibitor dasatinib has significant in vitro kinase inhibition against wild-type and mutant BCR-ABL, and significant clinical activity in patients with imatinib-resistant lymphoid blast phase CML (CML-LB) and Philadelphia-chromosome positive (Ph+) acute lymphoblastic leukemia (ALL). Aim To determine the long-term efficacy of the combination of the hyperCVAD regimen with dasatinib for treating patients with Ph+ ALL. Methods In this phase II trial, patients with newly diagnosed Ph+ ALL received dasatinib 50 mg po bid (or 100 mg daily) for the first 14 days of each of 8 cycles of alternating hyperCVAD and high dose cytarabine and methotrexate (induction/consolidation cycles). After 42 patients, the protocol was amended to give dasatinib 100 mg daily in the first 14 days of the first cycle and then 70 mg daily continuously from the second cycle. Patients in complete remission (CR) continued to receive maintenance dasatinib 50 mg po bid (or 100 mg daily) and vincristine and prednisone monthly for 2 years followed by dasatinib indefinitely. Patients eligible for allogeneic stem cell transplant proceeded to it in first CR. Results 63 patients with untreated Ph+ ALL and 9 patients with 1 or 2 prior cycles of chemotherapy (before Ph+/BCR-ABL+ status was known) have been enrolled in the study from September 2006 to March 2012. Patients have received a median of 6 cycles (range 1-8) of induction/consolidation. Median age is 55 years (range 21 – 80); 46 patients were older than 50 years, Median WBC at diagnosis was 12 x 109/L (range, 0.4 - 658.1 x 109/L). Ten patients had CNS involvement at presentation. All patients are evaluable for assessment of response to induction; 69 (96%) achieved CR after first cycle or were CR at start. 3 patients died before response assessment from infections. 57 of 69 (83%) evaluable patients achieved cytogenetic (CG) CR after 1 cycle; 5 had a major CG response (4 had 5% and one had 15% Ph+), 2 had insufficient metaphases, and 5 are unknown (no CG exam on day 21 marrow). To date, 45 patients (65%) have achieved complete molecular remission (CMR) and another 19 (28%) have achieved a major (but not complete) molecular response (MMR) at a median of 4 weeks from initiation of treatment (range, 2 – 38 weeks). Minimal residual disease assessment by flow cytometry is negative in 65 (94 %) patients at a median of 3 weeks (range, 2-37 weeks). The median time to neutrophil and platelet recovery for cycle 1 is 18 and 22 days and for subsequent cycles is 15 and 20 days. Grade 3 and 4 adverse events have included bleeding (GI, GU, soft tissue and subdural hematomas), pleural effusions, pericardial effusions, reversible rise in creatinine, deep vein thromboses, pulmonary emboli, as well as diarrhea, infections, hypophosphatemia, hypokalemia, hypocalcemia, hyperglycemia, and elevated transaminases. With a median follow up of 48 months in the surviving patients (range 16.5 - 81.5), 36 patients (50%) are alive and 31 (43%) are in CR. Twelve patients have undergone an allogeneic stem cell transplant. Thirty six patients have died [3 at induction, 16 after relapse, 7 post stem cell transplant performed in CR1, and 10 in CR (6 from infections, 1 from unrelated cardiac event, 1 from unrelated cancer, and 2 from an unknown cause)]. The median disease free survival is 31 months (range, 0.3 to 81) and the median overall survival is 44 months (range, 0.2 to 82). Twenty-one patients have relapsed with a median response duration of 16 months (range, 5 - 62) and 16 of them have died. In 6 patients morphological relapse was preceded by flow and molecular relapse. Six relapsed patients had ABL mutations (4 T315I, 1 F359V, and 1 V299L). Conclusion Combination of chemotherapy with dasatinib is effective in achieving long term remissions in patients with newly diagnosed Ph+ ALL. Disclosures: Ravandi: Bristol Myers Squibb: Honoraria, Research Funding. Off Label Use: Use of dasatinib for the frontline therapy of Ph+ ALL. O'Brien:Pharmacyclics: Research Funding. Jabbour:Bristol Myers Squibb: Consultancy, Honoraria. Cortes:Bristol Myers Squibb: Research Funding. Kantarjian:Bristol Myers Squibb: Research Funding.
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Mikhailova, Z. D., D. V. Pivovarov, and A. R. Pivovarova. "Features of Acute Coronary Syndrome in Combination with Oncological Diseases in Elderly and Senile Patients." Russian Archives of Internal Medicine 11, no. 2 (March 30, 2021): 122–31. http://dx.doi.org/10.20514/2226-6704-2021-11-2-122-131.
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Relevance. The presence of oncological diseases, high polymorbidity in elderly and senile patients can lead to a complicated course of acute coronary syndrome, including the development of acute kidney injury and/or chronic kidney disease, which contributes to a deterioration of the immediate and long-term prognosis and an increase in mortality.The research purposes. To study the course of acute coronary syndrome depending on the presence or absence of oncological diseases in elderly and senile people and to identify clinical and laboratory-instrumental features.Materials and methods. The study included 200 patients (men — n=122 (61 %), women — n=78 (39 %), Me age — 69 (65;77) years). The patients were divided into two groups: 1) the main group — acute coronary syndrome in combination with oncological diseases (n=100) (men — n=61 (61 %), women — n=39 (39 %), Me age — 69 (65;77) years); 2) the comparison group — acute coronary syndrome without oncological diseases (n=100). The groups were formed by the copy-pair method in a ratio of 1:1 by gender and age. All patients were evaluated for anamnesis parameters, the total number of diseases, the Charlson comorbidity index, the main clinical and laboratory-instrumental parameters and the development of complications. We collected an average portion of morning urine on the first day of hospitalization to determine the content of KIM-1 (pg/ml) in 40 patients of the main group and 47 from the comparison group. We collected daily urine on the 2nd day of hospital treatment to determine the level of K+, Na+, Cl-, uric acid and albumin.The results. Patients of the main group, according to the anamnesis, were more often diagnosed with stable angina (p = 0.042), diabetic kidney disease (p = 0.017), chronic kidney disease (p = 0.013) and anemia (p = 0.008). In addition, these patients had a higher Charleson comorbidity index [8 (6; 9) and 5 (4; 6) points; p <0.001] and a total number of diseases [6 (5; 7) and 4 (3; 5); p <0.001]. Patients with oncological diseases with the development of acute coronary syndrome more often complained of shortness of breath (p=0.008) and heart rhythm disturbance (p=0.004). In patients of the main group a lower left ventricular ejection fraction was diagnosed [51.0 (44; 55) and 54 (48; 57), p=0.013]. Acute kidney injury was more frequently diagnosed in the study group than in the comparison group (p <0.001), including acute kidney injury by “basal” creatinine (p=0.005), acute kidney injury by creatinine dynamics (p=0.047), and acute kidney injury by chronic kidney disease (p=0.003). The KIM-1 leel in patients of the main group was higher [921.0 (425.1; 1314.8) and 658.0 (345.6; 921.4) pg/ml; p=0.011]. In patients with acute kidney injury, in contrast to patients without acute kidney injury, a higher level of KIM-1 was detected [999.2 (480.8;1314.1) and 663.1 (360.5;905.2) pg/ml; p=0.008]. Patients with acute coronary syndrome and oncological diseases in the hospital were more likely to develop urgent complications (p=0.005), including death (p=0.024) and acute heart failure (p <0.001). They also had a higher incidence of early post-infarction angina (p=0.018) and anemia (p=0.005).Conclusions. Our study found that patients in the main group had a higher Charlson comorbidity index, a greater number of diseases, including stable angina, diabetic kidney disease, chronic kidney disease, and anemia. These patients with the development of acute coronary syndrome more often complained of shortness of breath and heart rhythm disturbance. Patients with oncological diseases were more often diagnosed with acute kidney damage, including “basal” creatinine, creatinine dynamics, and chronic kidney disease. The level of KIM-1 in the urine was higher in this group of patients. Patients of the main group in the hospital were more likely to develop urgent complications, including acute heart failure and death. There was also a high incidence of early post-infarction angina and anemia.
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Lee, Joo Myung, WonSeok Choe, Won-Woo Seo, Woo-Hyun Lim, Chan-Koo Kang, San Kyeong, Hyun-Ju Cho, et al. "Abstract 9971: Comparison of Stents Coated with Antibody against CD34 versus Vascular Endothelial-Cadherin: Anti-VE-Cadherin-Antibody-Coated Stents are Better In Rapid Endothelialization and Reduction of Neointimal Formation." Circulation 126, suppl_21 (November 20, 2012). http://dx.doi.org/10.1161/circ.126.suppl_21.a9971.
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Background Vascular endothelial-cadherin is exclusively expressed on the late endothelial progenitor cells. We evaluated whether anti-VE-cadherin antibody-coated stents might accelerate endothelial recovery and reduce neointimal formation more than anti-CD34 antibody-coated stents through the superior ability to capture the late EPC. Methods The BMS were coated with anti-VE-cadherin antibodies or anti-CD34 antibodies under the same condition. In vitro, the ability to capture EPC and specific cell capturing ability was evaluated. In vivo, re-endothelialization of stent in the rabbit iliac arteries was assessed by serial scanning electron microscopy. At 42 days, the area and proliferating activity of the neointima was compared between two stents. Results VE-cad stents showed higher number of adhering EPC (823.6 ± 182.2 versus 379.2 ± 137.2 cells/HPF, p<0.001). VE-cad stents also demonstrated better specific capturing of cells with endothelial lineage markers than CD34 stents did in flow cytometric analysis. VE-cad stents showed more effective re-endothelialization after 3 days in vivo. At 42 days, VE-cad stents demonstrated significantly smaller neointima area (0.92 ± 0.38 versus 1.24 ± 0.41 mm 2 , p=0.002) and significantly lower PCNA positive cells in neointima (1684.8 ± 658.8/mm 2 versus 2681.7 ± 375.1/mm 2 , p=0.008), compared with CD34 stents. Conclusions VE-cad stents captured EPC and endothelial cells more selectively in vitro, accelerated re-endothelialization over stents, and reduced neointimal formation in vivo, compared with CD34 stents. Targeting the VE-cadherin could be more reasonable strategy in developing the next generation pro-healing stents.
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Husak, Alexander B., Sydney A. Busch, Jordyn Robarge, and Jennifer L. Bankers‐Fulbright. "Gelsolin, but not mucin, inhibits P. aeruginosa swimming motility in vitro." FASEB Journal 31, S1 (April 2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.658.8.
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Pseudomonas aeruginosa is a ubiquitous, opportunistic pathogen responsible for substantial morbidity and mortality in patients with cystic fibrosis (CF). Following initial colonization of the CF lung, P. aeruginosa changes phenotype and becomes virtually impossible to inhibit, kill, or remove. Thus, understanding and preventing initial P. aeruginosa colonization is of great interest. Our lab has previously demonstrated that apical secretions from a human airway cell line, Calu‐3, inhibit P. aeruginosa swimming motility and biofilm formation in vitro, and that this inhibition is lost if proteins > 50 kDa are removed. However, secretions from Calu‐3 cells lacking the CFTR (CF‐like cells) do not inhibit P. aeruginosa. The goal of this project is to identify the inhibitory protein(s) present in non‐CF apical airway secretions. Using reducing SDS‐PAGE, we identified a band at approximately 90 – 100 kDa that was present in normal apical airway secretions but not CF‐like secretions, suggesting that a protein this size may be our target. We have begun testing readily available candidate proteins – mucin and gelsolin ‐‐ to see if they can replicate the inhibitory activity of non‐CF airway secretions. Mucin had no effect on P. aeruginosa swimming motility or biofilm formation, but gelsolin significantly inhibited swimming motility in a dose‐dependent manner. Interestingly, P. aeruginosa biofilm formation was not inhibited by gelsolin. Thus, gelsolin may be responsible for at least a part of the P. aeruginosa inhibition induced by apical airway secretions.Support or Funding InformationFunding provided by Augsburg College Undergraduate Research and Graduate Opportunities Office and the Augsburg College Biology Department
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Kaur, Prabhjot, Kitson Morden, Jayasankar Subramanian, and Ashutosh Singh. "Comparative analysis of physicochemical characteristics, bioactive components, and volatile profile of sour cherry (Prunus cerasus)." Canadian Journal of Plant Science, June 22, 2023. http://dx.doi.org/10.1139/cjps-2022-0263.
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This study provides a detailed report on the physicochemical, bioactive components, and volatile profile of diverse sour cherry (Prunus cerasus) cultivars to identify the cultivar(s) containing high health-promoting components. Physiological characteristics (fruit weight, size dimensions, moisture, color attributes, total soluble solids (TSS), pH, titratable acidity (TA), MI (Maturity Index), nutritional bioactive components (total phenolic, total anthocyanin content, total flavonoids), antioxidant activity, and volatile profile of 10 sour cherry cultivars, consisting of dark red Morello type and clear fruit flesh- Amarelle type were studied. The total phenolic content (TPC) was in the range of 123.24-289.91 mg GAE/ 100g FW (Fresh Weight), total flavonoids (1340.23- 2831.91 mg Quercetin Equivalent (QE/100g FW), and total anthocyanins (225.43-485.66 mg CGE/100g FW) in different sour cherry cultivars, showing significant diversity in such health-promoting compounds. In-vitro antioxidant activity assessed by FRAP was observed in the range of 658.18-1483.37 mg Trolox Equivalent (TE)/100g FW and by ABTS 384.36 and 931.85 mg TE/100g FW. A total of 10 phenolic components including 5 hydroxycinnamic acids, 3 flavonoids (flavanols and flavanol), and one anthocyanin have been identified and quantified by HPLC. Hydroxycinnamic acids represented the 40-60% composition of total phenolic components, while flavonoids and anthocyanins amounted to 20% each in total phenolic composition. The volatile profile of sour cherry cultivars revealed that aldehydes, alcohols, ketones, esters, monoterpenes, acids, sugars, and hydrocarbons were the predominant volatiles present in sour cherry.
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Zhao, Xin, Jian-feng Liu, Xin Su, De-yong Long, Cai-hua Sang, Ri-bo Tang, Rong-Hui Yu, et al. "Direct autotransfusion in the management of acute pericardial tamponade during catheter ablation for atrial fibrillation: An imperfect but practical method." Frontiers in Cardiovascular Medicine 9 (September 23, 2022). http://dx.doi.org/10.3389/fcvm.2022.984251.
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BackgroundAcute pericardial tamponade (APT) is one of the most serious complications of catheter ablation for atrial fibrillation (AF-CA). Direct autotransfusion (DAT) is a method of reinjecting pericardial blood directly into patients through vein access without a cell-salvage system. Data regarding DAT for APT are rare and provide limited information. Our present study aims to further investigate the safety and feasibility of DAT in the management of APT during the AF-CA procedure.Methods and resultsWe retrospectively reviewed 73 cases of APT in the perioperative period of AF-CA from January 2014 to October 2021 at our institution, among whom 46 were treated with DAT. All included patients successfully received emergency pericardiocentesis through subxiphoid access guided by X-ray. Larger volumes of aspirated pericardial blood (658.4 ± 545.2 vs. 521.2 ± 464.9 ml), higher rates of bridging anticoagulation (67.4 vs. 37.0%), and surgical repair (6 vs. 0) were observed in patients with DAT than without. Moreover, patients with DAT were less likely to complete AF-CA procedures (32/46 vs. 25/27) and had a lower incidence of APT first presented in the ward (delayed presentation) (8/46 vs. 9/27). There was no difference in major adverse events (death/disseminated intravascular coagulation/multiple organ dysfunction syndrome and clinical thrombosis) (0/0/1/0 vs. 1/0/0/0), other potential DAT-related complications (fever/infection and deep venous thrombosis) (8/5/2 vs. 5/3/1), and length of hospital stay (11.4 ± 11.6 vs. 8.3 ± 4.7 d) between two groups.ConclusionDAT could be a feasible and safe method to deal with APT during AF-CA procedure.
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Migita, S., S. Simodai-Yamada, K. Asakura, T. Mukaiyama, Y. Okumura, and H. Hao. "P2805Initial pathological responses of third-generation everolimus-eluting stents implantation: comparison with second-generation everolimus-eluting stents." European Heart Journal 40, Supplement_1 (October 1, 2019). http://dx.doi.org/10.1093/eurheartj/ehz748.1117.
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Abstract Background Third-generation drug-eluting stent (3rd DES) is commonly used now in percutaneous coronary intervention, and it has not only thinner struts, easier delivery than second-generation drug-eluting stent (2nd DES), but also abluminal biodegradable polymer. Clinical superiority of 3rd DES has been demonstrated compared to 1st and 2nd DESs. However, pathological response after 3rd DES implantation remains unclear. Purpose Pathological study of coronary artery after 3rd DES implantation have not been reported as far as we have referred to the previous studies. This study aimed to examine the initial tissue response after 3rd DES and 2nd DES implantation within one year. Methods Using specimens obtained by autopsy, we compared the histology between 3rd DES (n=3, 8 histological sections) and 2nd DES (n=6, 41 histological sections) lesions within 1 year after stent implantation to evaluate early tissue reaction. Stent segments were fixed with 10% buffered formalin and embedded in plastic, followed by hematoxylin–eosin, Masson's trichrome and elastica van Gieson. Ratio of covered stent struts by neointima was calculated. The thickness of neointima and the area of fibrin deposition were morphometrically evaluated. The degree of inflammation around struts was examined semi-quantitatively (score 0–3). Results The ratio of covered struts and thickness of neointima of 3rd DES were 0.84±0.04 and 68.2±10.3μm, while those of 2nd DES were 0.69±0.05 and 30.4±4.8μm respectively. The inflammation score was similar between two groups (1.00±0.14 vs. 1.02±0.16). The area of fibrin deposition around the struts was larger in 3rd DES compared with 2nd DES (1276.6±490.3μm2 vs. 658.0±173.4μm2). These results suggest that the 3rd DES may obtain prompt as well as rich covering of struts in the initial term after DES implantation. Although the biological feature of the polymers in 3rd and 2nd DESs is different, the inflammatory responses after both 3rd and 2nd DESs implantation were similar, at least within one year after deployment. The degree of inflammation was mild, less than approximately 50 inflammatory cells (score 1) around the struts. Conclusions Our pathological analysis showed advanced healing process in 3rd DES compared with 2nd DES lesions in the viewpoint of strut coverage by neointima. Observation of long-term pathological response may be required to evaluate the superiority of bioabsorbable polymer in 3rd DES.
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Li, Yu, Jin Li, Yaojun Hu, Ke Wang, Hongxia Yuan, Bingjian Sun, Hong-Lian Li, and Bin Lei. "Occurrence of Root-Lesion Nematode Pratylenchus coffeae on Corn in Xinjiang Uygur Autonomous Region, China." Plant Disease, April 22, 2022. http://dx.doi.org/10.1094/pdis-09-21-1988-pdn.
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Pratylenchus coffeae Filipjev & Schuurmans Stekhoven, 1941, is one of the most important root-lesion nematodes (RLN) parasitizing many agronomic and industrial crops (Wang et al. 2021). Corn (Zea mays L.) is one economically important crop in China, with 35 million hectares cultivated annually (Li et al. 2019). In July 2019, a survey of RLN was carried out in corn field planting with cultivar Heyu 187 in Chuanba village in Qitai County, Xinjiang Uygur Autonomous Region, China. Five root/soil samples were collected from poor growing plants with distinct brown lesions. Nematodes were extracted from the collected root/soil samples with the modified Baermann funnel method (Hooper et al. 2005). The average of 157 RLN per 100 cm3 of soil and 43 RLN per gram of fresh root were extracted. The obtained RLN were sterilized with 0.3% streptomycin sulfate and cultured on carrot disks at 25°C. Twenty petri dishes with carrot disks, each inoculated with one female. The morphological and molecular characteristics of RLN cultured on carrot disks were examined for species identification. Morphological measurements of adult females (n=15) included body length (range = 529.0 to 658.0 μm, mean = 571.0 μm), head with two lip annuli, stylet (15.5 to 17.0 μm, 16.0 μm), tail length (27.5 to 32.5 μm, 30.5 μm), a (23.8 to 32.9, 28.5), b (5.8 to 7.1, 6.5), c (16.5 to 23.4, 18.9), and V (76.6 to 83.1%, 80.8%). Morphological measurements of adult males (n=15) were body length (range = 479.5 to 568.0 μm, mean = 516.0 μm), head with two lip annuli, stylet (14.5 to 15.5 μm, 15.0 μm), tail length (24.0 to 29.0 μm, 26.0 μm), spicule length (16.4 to 19.0 μm, 17.5 μm), gubernaculum length (4.4 to 5.3 μm, 4.9 μm), a (29.2 to 32.5, 31.0), b (5.7 to 6.9, 6.2), and c (18.2 to 22.6, 19.8). The morphological characters of this population are consistent with the description of P. coffeae (Castillo and Vovlas, 2007). Nematode DNA was extracted from an individual female. The primers of D2A/D3B (5′-ACAAGTACCGTGAGGGAAAGTTG-3′/5′-TCGGAAGGAACCAGCTACTA-3′) (Subbotin et al. 2006) and 18S/26S (5'-TTGATTACGTCCCTGCCCTTT-3' / 5'-TTTCACTCGCCGTTACTAAGG-3') (Vrain et al. 1992) were used to amplify the D2/D3 expansion region of the 28S rRNA gene and the rDNA internal transcribed spacer (ITS) region, respectively. The PCR products were purified and transformed to E. coli strain DH5α, and then sequenced by Sangon Biotech Co. Ltd. (Shanghai, China). The obtained sequences of the D2/D3 region (793 bp) and the ITS region (1,242 bp) were submitted to GenBank, and the accession numbers for D2/D3 region were OK103614 and OK103619 which had 98.6% and 100% identity with the reported P. coffeae sequences (KC490925); the two obtained ITS sequences accession numbers OK103603 and OK103613) had more than 99% identity with published P. coffeae sequences from GenBank (e.g., LC030410, LC030395, MH134508 and LC030380). Hence, both morphological and molecular data demonstrated the presence of P. coffeae. To further confirm reproduction on corn, the obtained RLN population was used to inoculate corn plants in 2-liter pots containing 1.8-liter sterilized and mixed soil with 2 pastoral soil: 1 substrate in greenhouse at 27°C. About 15 days after sowing, each pot with one corn plant (cv. Heyu 187) with the same growth status was selected to inoculate P. coffeae. Five small holes near the roots were made using a glass rod. Approximately 1,000 mixed stage nematodes of P. coffeae were then pipetted into the holes of each plant. Eight replications were performed. Eight additional pots of uninoculated corn plants were used as control. After 2 months, corn roots were washed and brown lesions were observed on roots. The average number of RLN/pot was approximately 5,030 in soil and 2,870 in roots, and each pot had an average of 7.9 reproduction factors (final population/initial population), indicating that this nematode population infects and reproduces well on this corn cultivar. No nematodes and symptoms was detected in the control pot. The nematode of P. coffeae has only been reported on corn in Guangdong, Liaoning, Shangdong and Henan Provinces in China (Liu et al. 1996; Liu et al. 2001; Xia et al. 2021). To our knowledge, this is the first report of P. coffeae infecting corn in Xinjiang Uygur Autonomous Region of China. Since RLN can cause considerable damage to corn, one of the most important food crops produced in China, strategic measures should be taken to prevent the spread of P. coffeae to other regions.