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Shi, Wenbao, Jucai Chang, Yan Li, Dong Li, and Ru Hu. "Study on the Bearing Mechanism and Stability of Surrounding Rock in Original Roadway Filling and Nonpillar Tunneling." Geofluids 2023 (March 13, 2023): 1–12. http://dx.doi.org/10.1155/2023/2545442.
This study is focused on the problem that with the increase of coal seam mining depth, it is difficult to continuously replace mining due to complex roadway layout and unreasonable stope layout. By taking the mining geological conditions of the 62210 fully mechanized mining face of Xinzhuangzi Coal Mine in Huainan mining area, China, as the background, it explores the stress characteristics of the original roadway filling body as well as the stress distribution and deformation characteristics of roadway surrounding rock in original roadway filling and nonpillar tunneling (ORFNPT) through theoretical analysis and numerical simulation. The following findings are obtained. The required strength for the filling body is primarily determined by two factors, i.e., the span of the hanging roof that lies over the filling body and the width of the filling body. The span of the hanging roof is positively correlated with the required strength of the filling body. However, when the width of the filling body reaches a certain value, its further increase fails to change the required strength of the filling body. Compared with gob-side entry driving with small coal pillars, when the ORFNPT technology is applied to the lower-section roadway, the peak stress position in the solid coal on the lower side of the roadway is closer to the roadway sides, and the filling body is of a much higher stress than the small coal pillars. Besides, the roadway surrounding rock undergoes milder deformation. According to the on-site application and measurement data, the roof-to-floor convergence and side-to-side displacement amounts of the roadway are about 89 mm and 58 mm during tunneling of the 62310 working face, and the two amounts are about 910 and 1,290 mm during recovery of the 62310 working face, respectively. This tunneling method achieves an excellent roadway control effect.
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Olavarría, Alberto Sosa, Marisol García, María Martínez, and Deyanira Pereira. "OGP 6210 Seckel's syndrome." Ultrasound in Medicine & Biology 23 (January 1997): S125. http://dx.doi.org/10.1016/s0301-5629(97)80771-5.
Kingsburgh, R. L., M. Komljenovic, J. A. López, and M. Peimbert. "Recombination line abundances in NGC 6210." Symposium - International Astronomical Union 180 (1997): 250. http://dx.doi.org/10.1017/s0074180900130694.
We present abundances derived from echelle spectroscopy of the planetary nebula NGC 6210 from the forbidden, collisionally excited lines, and from the permitted, recombination lines. We have obtained spectra from 3 positions in the nebula: at the central star, and 6 and 12 arcseconds south of the central star. We find a discrepancy of a factor of 2 between the O2+/H+ ratio derived by the recombination lines and by the forbidden lines in each spatial position. This discrepancy may result from the presence of temperature fluctuations in NGC 6210, where the collisionally excited lines are exponentially weighted to regions of higher temperature. A value for the root-mean-square temperature fluctuation parameter t2(OIIabun)= 0.038+0.007–0.009 is derived for the central star spectrum, 0.040+0.006–0.013 for the 6 arcsecond offset, and 0.051+0.014–0.015 for the 12 arcsecond offset spectrum. Thus no significant variation in t2 is seen as a function of spatial position within the nebula. We have also estimated t2 by comparing the derived Balmer Jump temperature at the 6 arcsecond offset, Te(BaJ)= 7900+2400–1600K, with the temperature derived from the [O III] 5007/4363å ratio Te[O III]= 9370±100K at this position. This comparison suggest t2(BaJ)= 0.041±0.020, in agreement with the values for t2 as estimated from the recombination lines.
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Pottasch, S. R., J. Bernard-Salas, and T. L. Roellig. "Abundances in the planetary nebula NGC 6210." Astronomy & Astrophysics 499, no. 1 (March 25, 2009): 249–56. http://dx.doi.org/10.1051/0004-6361/200911654.
Marcinkowska-Ochtyra, Adriana, Krzysztof Gryguc, Adrian Ochtyra, Dominik Kopeć, Anna Jarocińska, and Łukasz Sławik. "Multitemporal Hyperspectral Data Fusion with Topographic Indices—Improving Classification of Natura 2000 Grassland Habitats." Remote Sensing 11, no. 19 (September 28, 2019): 2264. http://dx.doi.org/10.3390/rs11192264.
Accurately identifying Natura 2000 habitat areas with the support of remote sensing techniques is becoming increasingly feasible. Various data types and methods are used for this purpose, and the fusion of data from various sensors and temporal periods (terms) within the phenological cycle allows natural habitats to be precisely identified. This research was aimed at selecting optimal datasets to classify three grassland Natura 2000 habitats (codes 6210, 6410 and 6510) in the Ostoja Nidziańska Natura 2000 site in Poland based on hyperspectral imagery and botanical on-ground reference data acquired in three terms during one vegetative period in 2017 (May, July and September), as well as a digital terrain model (DTM) obtained by airborne laser scanning (ALS). The classifications were carried out using a random forest (RF) algorithm on minimum noise fraction (MNF) transform output bands obtained for single terms, as well as data fusion combining the topographic indices (TOPO) calculated from the DTM, multitemporal hyperspectral data, or a combination of the two. The classification accuracy statistics were analysed in various combinations based on the datasets and their terms of acquisition. Topographic indices improved the classification accuracy of habitats 6210 and 6410, with the greatest impact noted in increased classification accuracy of xerothermic grasslands. The best terms for identifying specific habitats were autumn for 6510 and summer for 6210 and 6410, while the best results overall were obtained by combining data from all terms. The highest obtained values of the F1 coefficient were 84.5% for habitat 6210, 83.2% for habitat 6410, and 69.9% for habitat 6510. Comparing the data fusion results for habitats 6210 and 6410, greater accuracy was obtained by adding topographic indices to multitemporal hyperspectral data, while for habitat 6510, greater accuracy was obtained by fusing only multitemporal hyperspectral data.
Yao, Shengrui, Ian A. Merwin, and Michael G. Brown. "Root Dynamics of Apple Rootstocks in a Replanted Orchard." HortScience 41, no. 5 (August 2006): 1149–55. http://dx.doi.org/10.21273/hortsci.41.5.1149.
Root observations in situ with a rhizotron camera enabled us to compare the performance of apple (Malus ×domestica Borkh.) trees on 3 rootstock clones planted in a New York orchard with a history of apple replant disease. Visual observations were conducted in situ at monthly intervals during 2 growing seasons through minirhizotron tubes for trees grafted onto 3 rootstocks: M.7 (M.7), Geneva 30 (G.30), and Cornell-Geneva 6210 (CG.6210). There were 3 preplant soil treatments (fumigation, compost amendment, and untreated checks) and 2 tree planting positions (within the old tree rows or in the old grass lanes of the previous orchard at this site). Preplant soil treatments and old-row versus grass-lane tree planting positions had no apparent influence on root systems, whereas rootstock clones substantially influenced root growth and demography. New root emergence was suppressed during the first fruit-bearing year (2004) on all 3 rootstock clones compared with the previous nonbearing year (2003). A root-growth peak in early July accounted for more than 50% of all new roots in 2003, but there was no midsummer root-growth peak in 2004. The median lifespan for roots of CG.6210 was twice that of G.30 and M.7 in 2004. Also, CG.6210 had more roots below 30 cm depth, whereas M.7 had more roots from 11 to 20 cm depth. Trees on CG.6210 were bigger, yielded more fruit, and had the highest yield efficiency in the third year after planting compared with trees on G.30 and M.7 rootstocks. Crop load appeared to inhibit new root development and changed root-growth dynamics during the first bearing year, with a resurgence in new root growth after fruit was harvested in October 2004. Rootstock genotype was the dominant influence on root lifespan and distribution in this study, whereas preplant soil fumigation, compost amendments, and replanting positions had little apparent impact on root characteristics despite their influence on above-ground tree growth and yield.
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Mukhopadhyay, N., and S. Chattopadhyay. "Simultaneous Estimation of Proportions in a Finite Population." Calcutta Statistical Association Bulletin 43, no. 1-2 (March 1993): 65–74. http://dx.doi.org/10.1177/0008068319930106.
Sequential and multistage sampling strategies via simple random sampling without replacement, are proposed for simultaneously estimating several proportions in a finite population. Various asymptotic first-order properties are addressed, while some limited moderate sample performance have also been included. AMS (1980) Subject Classification: Primary 62L99; Secondary 62L12
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Bhattacharya, Rahul, S. Maiti Sudhansu, Mouli Choudhury Mriganka, and Dipangsu Mukherjee. "Minimum Variance Unbiased Estimation of Reliability Function for a Class of Generalizations of Lindley Distribution." Calcutta Statistical Association Bulletin 72, no. 1 (May 2020): 43–57. http://dx.doi.org/10.1177/0008068320923428.
Uniformly minimum variance unbiased (UMVU) estimators of reliability function (both stress–strength and mission time) and the associated variance are derived for a class of generalization of Lindley distribution. The application of the results is further validated by a real data study. AMS 2020 subject classification: 62N05 62F10
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Smitha, S., K. R. Muraleedharan Nair, and P. G. Sankaran. "On Measures of Affinity for Truncated Distributions." Calcutta Statistical Association Bulletin 59, no. 3-4 (September 2007): 151–62. http://dx.doi.org/10.1177/0008068320070303.
Abstract: In the present paper we define affinity for truncated distributions and examine its properties. The relationship of this measure with other discrimination measures is examined. We also provide a characterization result for the proportional hazard model using the functional form of the truncated affinity. AMS (2000) Subject Classification: 62E10, 90B25
Dans cette thèse, nous étudions d'abord le problème de l'optimisation d'ordre zéro dans le cadre actif pour des fonctions lisses et trois classes différentes de fonctions : i) les fonctions qui satisfont la condition de Polyak-Łojasiewicz, ii) les fonctions fortement convexes, et iii) la classe plus large des fonctions non convexes fortement lisses.De plus, nous proposons un nouvel algorithme basé sur la randomisation de type l1, et nous étudions ses propriétés pour les fonctions convexes Lipschitz dans un cadre d'optimisation en ligne. Notre analyse est due à la dérivation d'une nouvelle inégalité de type Poincar'e pour la mesure uniforme sur la sphère l1 avec des constantes explicites.Ensuite, nous étudions le problème d'optimisation d'ordre zéro dans les schémas passifs. Nous proposons une nouvelle méthode pour estimer le minimiseur et la valeur minimale d'une fonction de régression lisse et fortement convexe f. Nous dérivons des limites supérieures pour cet algorithme et prouvons des limites inférieures minimax pour un tel cadre.Enfin, nous étudions le problème du bandit contextuel linéaire sous contraintes d'équité où un agent doit sélectionner un candidat dans un pool, et où chaque candidat appartient à un groupe sensible. Nous proposons une nouvelle notion d'équité qui est pratique dans l'exemple susmentionné. Nous concevons une politique avide qui calcule une estimation du rang relatif de chaque candidat en utilisant la fonction de distribution cumulative empirique, et nous prouvons sa propriété optimale In this thesis, we first study the problem of zero-order optimization in the active setting for smooth and three different classes of functions: i) the functions that satisfy the Polyak-Łojasiewicz condition, ii) strongly convex functions, and iii) the larger class of highly smooth non-convex functions.Furthermore, we propose a novel algorithm that is based on l1-type randomization, and we study its properties for Lipschitz convex functions in an online optimization setting. Our analysis is due to deriving a new Poincar'e type inequality for the uniform measure on the l1-sphere with explicit constants.Then, we study the zero-order optimization problem in the passive schemes. We propose a new method for estimating the minimizer and the minimum value of a smooth and strongly convex regression function f. We derive upper bounds for this algorithm and prove minimax lower bounds for such a setting.In the end, we study the linear contextual bandit problem under fairness constraints where an agent has to select one candidate from a pool, and each candidate belongs to a sensitive group. We propose a novel notion of fairness which is practical in the aforementioned example. We design a greedy policy that computes an estimate of the relative rank of each candidate using the empirical cumulative distribution function, and we proved its optimal property
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Nicholls, Angela. "Early modern English almshouses in the mixed economy of welfare c. 1550-1725." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/62710/.
Almshouses providing accommodation for poor people are a common feature of the towns and villages of England, but in the historical literature are rarely considered to have made a genuine contribution to the poor and needy. This study examines the extent and nature of almshouse provision in early modern England, and places this within the context of overall approaches to the poor in the period. The archival research focuses on the contrasting counties of Durham, Warwickshire and Kent between about 1550 and 1725. Information on all the almshouse foundations in those areas is collated and summarised in an appendix, enabling both quantitative and qualitative evaluations to be made. A detailed analysis of the policy background to housing the poor provides the context for the study, and reveals that almshouses were initially seen as part of a national as well as local solution to the problem of poverty. Many of the diverse people involved in founding and running almshouses responded to this agenda, motivated by political responsibility and particular group identities, rather than just the desire for personal memorialisation. A case study of a single almshouse exemplifies the way this parish used the almshouse alongside other resources to meet the needs of the poor. Overall, there was a surprising variation in the socio-economic status of almshouse occupants and their experience of almshouse life. In many almshouses, occupants’ standard of living was similar to that of other poor people, including parish paupers. The guaranteed nature of the benefits and security of the accommodation were, however, distinct advantages, and most almspeople were able to enjoy considerable independence and autonomy, with women possibly benefiting most. Over the period, however, statutory poor relief and the introduction of workhouses enabled almshouses to develop as more exclusive institutions, which were less embedded in local welfare systems.
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Bateman, James. "Virtual patient design in undergraduate education." Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/62110/.
Background Virtual patients (VPs) are computerised online representations of realistic clinical cases. Recent technology and software advances position VPs as a standardised, accessible, collaborative teaching tool. We do not know how they should be designed. My research question is: how do different VP design principles influence student experiences when completing VPs? The aim of this study is to provide qualitative and quantitative research evidence to support VP design and development. Methods This research project uses qualitative and quantitative methods to evaluate how VP design influences medical student learning, based on groups of students from three UK medical schools (Warwick, Birmingham, Keele). The initial qualitative research component is a grounded theory (GT) focus group study evaluating VP design properties. The literature review and qualitative research identified the two most important VP properties to research were: (1) branching within the cases; and (2) structured clinical reasoning instruction (SR) intended to promote good clinical decision making in the VPs. The quantitative research component is a multi-centre randomised experimental 2x2 factorial study of undergraduate students at three UK medical schools, conducted to a published protocol. I investigate two most important independent VP design variables: (1) branching, present or absent; (2) SR, present or absent. Outcomes including: (a) VP scores; (b) VP student evaluations; (c) metrics collected from the VP environment; (d) student self-reported case preferences and (e) summative assessment results. The study has institution ethics approval. Results In the qualitative study of six focus groups (n=46), I produced a model describing how VP design influences learning. In the quantitative research, 572 students completed 1773 VPs, and 1223 evaluations, with 296 (50.1%) students completing all four VPs (1184). Key findings were: student expressed preferred SR when present (70.5% of student, P<0.001); there were no significant differences in adjusted global VP scores or evaluation scores (all p>0.3 for the independent variables); institution factors played an important role with higher scores at one centre (p<0.001); and there were significant improvements in Bayesian reasoning with SR present (7% improvement, p<0.001). Discussion This original research is the first GT study into VPs. The quantitative component is the largest study to date in the literature exploring VP design variables. It provides practical lessons for authors and institutions for design and delivery of VPs. All VPs used are available as open education resources.
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Hall, Benjamin. "Plant pathogen effector proteins and their host targets : functional studies and manipulation to generate enhanced resistance." Thesis, University of East Anglia, 2016. https://ueaeprints.uea.ac.uk/62310/.
As global population expands, so does its demand for food. This will require vast amounts of plant-derived calories. This increased pressure means it is vital that we do more with less; less land, less water, less chemical input and less labour. One major threat to crop production is posed by plant pests and pathogens. In particular, filamentous plant pathogens – oomycetes and fungi – are among the most devastating organisms known to agriculture. With their rapidly evolving genomes which specialise in breaking plant immune systems and chemical control methods, control of these pathogens is becoming extremely problematic. Especially as they often encounter crops in monoculture. An often overlooked potential strategy for developing pathogen resistance is manipulation of the host targets of plant pathogen effector proteins. In order to manipulate such targets to condition enhanced resistance, one must first develop a sound understanding of the interaction between effector and target, the target’s function in planta and which processes are being perturbed by the interaction. A previously discovered interaction between a P. infestans RXLR effector and a host MAPK known to be a positive regulator of immunity, where the effector acts to perturb positive regulation of immunity, is used here to investigate the possibility of manipulating a host target for enhanced immunity. Effector-insensitive variants were produced and characterised, prior to expression in CRISPR-edited tomato plants. We tentatively suggest that at least one variant may condition enhanced resistance. Another interactor of the same effector protein was investigated for its role in immunity and evidence suggesting it may function as a helper of the effector is presented. Additionally, the expression, purification and crystallisation of native and heavy atom derivatives of a candidate effector protein from B. graminis f.sp. hordeii is demonstrated.
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Rybaczuk, Krysia. "Error processes in the integration of digital cartographic data in geographic information systems." Thesis, Durham University, 1992. http://etheses.dur.ac.uk/6210/.
Errors within a Geographic Information System (GIS) arise from several factors. In the first instance receiving data from a variety of different sources results in a degree of incompatibility between such information. Secondly, the very processes used to acquire the information into the GIS may in fact degrade the quality of the data. If geometric overlay (the very raison d'etre of many GISs) is to be performed, such inconsistencies need to be carefully examined and dealt with. A variety of techniques exist for the user to eliminate such problems, but all of these tend to rely on the geometry of the information, rather than on its meaning or nature. This thesis explores the introduction of error into GISs and the consequences this has for any subsequent data analysis. Techniques for error removal at the overlay stage are also examined and improved solutions are offered. Furthermore, the thesis also looks at the role of the data model and the potential detrimental effects this can have, in forcing the data to be organised into a pre-defined structure.
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Chowdhury, Soumyadeb. "Exploring the memorability of multiple recognition-based graphical passwords and their resistance to guessability attacks." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6210/.
Most users find it difficult to remember traditional text-based passwords. In order to cope with multiple passwords, users tend to adopt unsafe mechanisms like writing down the passwords or sharing them with others. Recognition-based graphical authentication systems (RBGSs) have been proposed as one potential solution to minimize the above problems. But, most prior works in the field of RBGSs make the unrealistic assumption of studying a single password. It is also an untested assumption that RBGS passwords are resistant to being written down or verbally communicated. The main aim of the research reported in this thesis is to examine the memorability of multiple image passwords and their guessability using written descriptions (provided by the respective account holders). In this context, the thesis presents four user studies. The first user study (US1) examined the usability of multiple RBGS passwords with four different image types: Mikon, doodle, art and everyday objects (e.g. images of food, buildings, sports etc.). The results obtained in US1 demonstrated that subjects found it difficult to remember four RBGS passwords (of the same image type) and the memorability of the passwords deteriorated over time. The results of another usability study (US2) conducted using the same four image types (as in US1) demonstrated that the memorability of the multiple RBGS passwords created by employing a mnemonic strategy do not improve even when compared to the existing multiple password studies and US1. In the context of the guessability, a user study (GS1) examined the guessability of RBGS passwords (created in US1), using the textual descriptions given by the respective account holders. Another study (GS2) examined the guessability of RBGS passwords (created in US2), using descriptions given by the respective account holders. The results obtained from both the studies showed that RBGS passwords can be guessed using the password descriptions in the experimental set-up used. Additionally, this thesis presents a novel Passhint authentication system (PHAS).The results of a usability study (US3) demonstrated that the memorability of multiple PHAS passwords is better than in existing Graphical authentication systems (GASs). Although the registration time is high, authentication time for the successful attempts is either equivalent to or less than the time reported for previous GASs. The guessability study (GS3) showed that the art passwords are the least guessable, followed by Mikon, doodle and objects in that order. This thesis offers these initial studies as a proof of principle to conduct large scale field studies in the future with PHAS. Based on the review of the existing literature, this thesis identifies the need for a general set of principles to design usability experiments that would allow systematic evaluation and comparison of different authentication systems. From the empirical studies (US1, US2 and US3) reported in this thesis, we found that multiple RBGS passwords are difficult to remember, and the memorability of such passwords can be increased using the novel PHAS. We also recommend using the art images as the passwords in PHAS, because they are found to be the least guessable using the written descriptions in the empirical studies (GS1, GS2 and GS3) reported in this thesis.
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Páez, Sergio, Celeste Valdés, and Daniel Velázquez. "La educación." Bachelor's thesis, Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Escuela de Enfermería, 2013. http://bdigital.uncu.edu.ar/6210.
La Diabetes mellitus es una enfermedad que afecta a todos los Individuos sin distinción alguna de edad, sexo ni nivel económico. Constituye la tercera causa de mortalidad a nivel mundial. En los últimos tiempos, producto del ritmo de la vida y diversos problemas se ha notado una reincidencia en la patología Diabetes en el servicio de clínica médica del Hospital Enfermeros Argentinos de General Alvear. Se toma para esta investigación una población de 40 personas diabéticas internadas en el servicio de clínica médica con una muestra de 20 pacientes reincidentes, desde el mes de Enero de 2013 hasta el mes de abril 2013.
Los objetivos de este trabajo son: conocer las causas o factores por los que reinciden los pacientes con patologías diabéticas, definir si la educación es una buena estrategia para disminuir o anular la reincidencia y conocer el grado de escolaridad y los conocimientos previos del paciente sobre la enfermedad para utilizar vocabulario específico y adecuado. Fil: Páez, Sergio. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Escuela de Enfermería.. Fil: Valdés, Celeste. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Escuela de Enfermería.. Fil: Velázquez, Daniel. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Escuela de Enfermería..
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Alberti, Paolo. "Analisi per via simulativa del protocollo tcp a ritrasmissione asimmetrica anticipata su wifi." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amslaurea.unibo.it/6210/.
Cocchi, Stefania <1970>. "Caratterizzazione biomolecolare delle neoplasie lipomatose." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6210/.
Tra i liposarcomi, il tumore lipomatoso atipico/liposarcoma ben differenziato e il liposarcoma dedifferenziato rappresentano i sottotipi più frequenti.
Spesso è difficile distinguere questi tumori da altri con caratteristiche morfologiche simili. Da un punto di vista citogenetico sono caratterizzati dalla presenza di cromosomi soprannumerari giganti e cromosomi ad anello costituiti principalmente da sequenze amplificate della regione 12q13-15.
In questa regione mappano numerosi geni tra cui il gene MDM2 (murine double minute-2).
La caratterizzazione molecolare di tali sottotipi diventa estremamente importante sia a fini diagnostici sia per un corretto indirizzo terapeutico, soprattutto oggi, dopo l’introduzione nella pratica clinica di terapie biologiche mirate (targeted therapies).
Nel presente studio viene analizzato il ruolo dell’analisi FISH per la valutazione dello status di MDM2 nelle neoplasie lipomatose e per stabilire se questo marcatore possa essere utilizzato nella diagnosi differenziale di questi tumori. Sebbene questo studio confermi l’utilità diagnostica dell’amplificazione di MDM2 nella diagnosi del tumore lipomatoso atipico/liposarcoma ben differenziato ed il liposarcoma dedifferenziato, questo marcatore potrebbe avere in futuro anche una più ampia applicazione.
Data la recente introduzione degli inibitori selettivi di MDM2 tale ricerca risulta importante non solo a fini diagnostici ma anche per la selezione dei pazienti che potranno in futuro beneficiare del trattamento con tali inibitori.
Questo studio è stato effettuato anche per analizzare la rilevanza biologica del percorso che vede coinvolto il gene AKT nel liposarcoma ben differenziato e dedifferenziato e per stabilire se questo percorso possa rappresentare un utile bersaglio terapeutico in questi tumori. I dati ottenuti dimostrano che AKT è espresso ed attivato in tutti i casi di tumore lipomatoso atipico/liposarcoma ben differenziato e liposarcoma dedifferenziato. Among the liposarcomas, the atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma subtypes are more frequent.
It is often difficult to distinguish these from other tumors with similar morphological characteristics. The cytogenetic hallmark of these tumors is he presence of supernumerary chromosomes and giant ring chromosomes which consist mainly of amplified sequences of the region 12q13-15.
In this region mapped several genes including the gene MDM2 ( murine double
Minute-2).
The molecular characterization of these subtypes becomes extremely important both for diagnostic purposes and for a correct therapeutic approach , especially today, after the introduction into clinical practice of targeted biological therapies (targeted therapies).
In the present study is analyzed the role of FISH analysis for the evaluation of the MDM2 status in lipomatous neoplasms and to determine whether this marker could be used in the differential diagnosis of these tumors. Although this study confirms the diagnostic utility of MDM2 amplification in the diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma, this marker could have in the future a wider application .
Given the recent introduction of selective inhibitors of MDM2 such research is important not only for diagnostic purposes but also for the selection of patients who may in the future benefit from treatment with these inhibitors.
This study was also performed to analyze the biological relevance of the pathway that involves the AKT gene in well-differentiated and dedifferentiated liposarcoma and to determine whether this pathway may represent a useful therapeutic target in these tumors . The data obtained demonstrate that AKT is expressed and activated in all cases of atypical lipomatous tumor/well differentiated liposarcoma and dedifferentiated liposarcoma .
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Lachos, Victor H., and Filidor V. Labra. "Multivariate skew-normal/independent distributions: properties and inference." Pontificia Universidad Católica del Perú, 2014. http://repositorio.pucp.edu.pe/index/handle/123456789/97108.
Liu (1996) discussed a class of robust normal/independent distributions which contains a group of thick-tailed cases. In this article, we develop a skewed version of these distributions in the multivariate setting, and we call them multivariate skew normal/independent distributions. We derive several useful properties for them. The main virtue of the members of this family is that they are easy to simulate and lend themselves to an EM-type algorithm for maximum likelihood estimation. For two multivariate models of practical interest, the EM-type algorithm has been discussed with emphasis on the skew-t, the skew-slash, and the contaminated skew-normal distributions. Results obtained from simulated and two real data sets are also reported. Liu (1996) discute una clase de distribuciones robustas a las que apela como normal/independiente, y que contiene un grupo de distribuciones de colas pesadas. En este artículo desarrollamos una versión asimétrica de tales distribuciones en un escenario multivariado, a las que llamaremos distruciones normales asimétricas independientes multivariadas. Para tales distribuciones derivamos algunas propiedades. La principal virtud de los miembros de esta familia es que son fáciles de simular y se prestan a un algoritmo de tipo EM para realizar estimaciones de máxima verosimilitud de sus parámetros. Para dos modelos multivariados de interés práctico se discute el algoritmo EM con énfasis en las distribuciones t-asimétrica, slash asimétrica y normal asimétrica contaminada. Los resultados obtenidos a partir de simulaciones y de dos conjuntos de datos reales son reportados.
U.S. Nuclear Regulatory Commission., ed. Computer Codes For Evaluation Of Control Room Habitability (Habit V1.1)... NUREG/CR-6210, Supp. 1... U.S. Nuclear Regualtory Commission. [S.l: s.n., 1999.
Löfqvist, Hilde. Hormontherapie in den Wechseljahren. Berlin, Heidelberg: Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-62710-5.
Federer, Herbert. Geometric Measure Theory. Edited by B. Eckmann and B. L. van der Waerden. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-62010-2.
Kingsburgh, R. L., M. Komljenovic, J. A. López, and M. Peimbert. "Recombination Line Abundances in NGC 6210." In Planetary Nebulae, 250. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5244-0_105.
Bay-Larsen, Ingrid, Berit Skorstad, and Brigt Dale. "Mining and Arctic Communities." In The Will to Drill - Mining in Arctic Communites, 1–11. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-62610-9_1.
Gjertsen, Arild, and Camilla Risvoll. "Coexistence in Mountain Landscapes: A Local Narrative of Hope and Uncertainty." In The Will to Drill - Mining in Arctic Communites, 197–211. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-62610-9_10.
Dale, Brigt, Ingrid Bay-Larsen, and Berit Skorstad. "The Will to Drill. Revisiting Arctic Communities." In The Will to Drill - Mining in Arctic Communites, 213–28. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-62610-9_11.
Skorstad, Berit, Brigt Dale, and Ingrid Bay-Larsen. "Governing Complexity. Theories, Perspectives and Methodology for the Study of Sustainable Development and Mining in the Arctic." In The Will to Drill - Mining in Arctic Communites, 13–32. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-62610-9_2.
Gjertsen, Arild, Vladimir Didyk, Rasmus Ole Rasmussen, Galina Kharitonova, and Ludmila Ivanova. "Institutional Conditions in Arctic Frontiers: The Case of Mining in Greenland, Russia and Norway." In The Will to Drill - Mining in Arctic Communites, 33–59. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-62610-9_3.
Goes, Sander, and Berit Skorstad. "Legitimizing Business?: Environmental Awareness in the Norwegian Mining Industry." In The Will to Drill - Mining in Arctic Communites, 61–80. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-62610-9_4.
Bjørgo, Frode. "Metagoverning the Interdependence of Municipalities and Mining Companies in the Scandinavian Arctic." In The Will to Drill - Mining in Arctic Communites, 81–101. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-62610-9_5.
Didyk, Vladimir, Ingrid Bay-Larsen, Håkan Sandersen, Ludmila Ivanova, Ludmila Isaeva, and Galina Kharitonova. "Sustainability and Mining: The Case of the Kola Peninsula." In The Will to Drill - Mining in Arctic Communites, 103–25. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-62610-9_6.
Rasmussen, Rasmus Ole, and Arild Gjertsen. "Sacrifice Zones for a Sustainable State? Greenlandic Mining Politics in an Era of Transition." In The Will to Drill - Mining in Arctic Communites, 127–49. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-62610-9_7.
"Effect of High Dosage of a Set Retarder on the Properties of Fresh and Hardened Concrete." In SP-173: Fifth CANMET/ACI International Conference on Superplasticizers and Other Chemical Admixtures in Concrete. American Concrete Institute, 1997. http://dx.doi.org/10.14359/6210.
Hansen, Michael R., Torben Ole Andersen, and Morten Kjeld Ebbesen. "Multi Criteria Design Improvement of Commercial Loader Crane." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-62410.
An approach to systematically deriving the optimal use of operator-in-the-loop machinery is presented. The operation is considered as a set of design variables that similarly to classical design variables such as geometry and materials may be manipulated with a view to reach certain performances. The emphasis of the paper is on mobile loader cranes and an example on the development of the lifting capacity diagram of such a crane is used to illustrate the potential benefits of employing the presented approach. In general, physical data is not given for the loader crane due to limited space, however, the authors will be happy to provide more details for anyone interested.
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Han, Lu, and Liming Dai. "Spherical Wave Propagations of Multiple Energy Sources in Fluid-Saturated Elastic Porous Media." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-62110.
This research focuses on quantitative analysis of elastic space waves propagating porous media saturated with fluid. Compressive wave propagations are described in three dimensional (3-D) spherical coordinates in terms of displacements of the fluid and solid of the porous media. The wave superposition properties under multiple energy resources are investigated. Relative displacements between the fluid and solid of a porous medium in 3-D domain are quantified with consideration of the wave propagations excited by multiple point energy sources. Numerical analyses are performed and practically sound results are obtained.
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Abdelkader, Filali, Lyes Khezzar, Dennis A. Siginer, and Zoubir Nemouchi. "Graetz Problem in Ducts of Circular and Some Non-Circular Cross-Sections With Viscoelastic Fluids." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-62210.
An investigation of heat transfer with viscoelastic fluids in straight pipes of circular and some non-circular cross-sections is carried out. The influence of the rheological parameters on heat transfer enhancement with viscoelastic fluids in the entrance region of tube flow is investigated with negligible axial heat conduction and viscous dissipation. Numerical simulations are conducted with constant wall heat flux for the Graetz problem using the finite element based software Polyflow for viscoelastic fluids of the simplified Phan-Thien Tanner (SPPT) type. It is found that increasing the fluid elasticity, for all cross-sections, raises the normalized heat transfer coefficient for relatively low elasticity values but for high level of fluid elasticity the normalized heat transfer coefficient decreases.
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Pandey, K. M., and Sivasakthivel Thangavel. "CFD Analysis of Scramjet Combustor Using Strut With Circular and Planer Injector." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-62310.
The simulation of a supersonic reactive flow is an important tool for the investigation and development of Scramjet engines. Numerical investigations have become less expensive than experiments. In this research work mixing and combustion for different type of strut injector is studied especially for strut with circular injector and strut with planer injector, in this work DLR scramjet combustor model is used, it having length of 340mm, width of 40mm, inlet entry height of 50mm and exit height of the combustor is 62mm. In this combustor strut is placed at the distance of 77mm from the inlet. Total length of the strut is 32mm. Air entry Mach number is 2, temperature and pressure of the air is 340k and 1 bar, at the base of the strut hydrogen will be injected at a Mach number of 1, temperature and pressure of the Hydrogen is 250k and 1 bar. Combustion will be initiated using pre burning of small amount of hydrogen and oxygen. In this CFD analysis two-dimensional coupled implicit NS equation, the standard k-ε turbulence model and the finite-rate/eddy-dissipation reaction model have been applied to numerically simulate the flow field of the hydrogen fuelled scramjet combustor. From analysis it is found that strut with planer injector giving good mixing efficiency, combustion efficiency and total pressure loss is less as compared to strut with circular injector. In both cases subsonic regions at the channel symmetry axis are responsible for flame holding. If the combustor geometry is chosen in a favourable way these subsonic zones may be kept small. Moreover, the flames are away from solid walls thus minimizing the wall heat load.
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Lamont, Justin A., Srinath V. Ekkad, and Mary Anne Alvin. "Heat Transfer Distribution of Various Rib Geometries for Developing Flow at High Rotation Numbers." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-62610.
The Coriolis force and centrifugal buoyancy have a significant effect on the cooling performance for rotating internal serpentine coolant channels in gas turbine blades. As coolant flow in rotation is highly complex, detailed knowledge of the heat transfer over a surface will greatly enhance the blade designer’s ability to predict hot spots so coolant may be distributed effectively. The present study uses a novel transient liquid crystal technique to measure heat transfer on a rotating, radially outward coolant channel, which is a simplified model of the actual coolant channels. Various rib types such as 90°, W, and M-shaped ribs of varying types are used to roughen the walls. The present study measures the effects of high rotation numbers (Ro) on the performance and heat transfer distribution of different rib types in developing flow. The present study measures how effective the ribs are up to Ro = 0.5. The Reynolds number (Re) is held constant at 12,000. Results show that in the developing region, the W and M-shaped “high-performance” ribs are just as effective as the simple 90° ribs for increasing heat transfer. The entrance effect in the developing region causes significantly high baseline heat transfer enhancement which may explain why ribs are not as effective as they are in the fully developed region. As the rotation number is increased, results show that the heat transfer on the trailing side increases, while the leading side decreases to a limit and remains constant. For all rotational cases, the W and M-shaped ribs show large changes to the heat transfer distributions on the leading and trailing sides.
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Alkhoury, Philip, Mourad Aït-Ahmed, Abdul-Hamid Soubra, and Valentine Rey. "Vibration Control of an Offshore Wind Turbine." In ASME 2021 40th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/omae2021-62210.
Abstract In order to reduce their cost, offshore wind turbines (OWTs) must have a powerful generator and a minimum overall weight. This has the consequence of making the OWT structure sensitive to dynamic excitations even at low frequencies. Indeed, modern multi-megawatt OWTs are composed of slender flexible and lightly damped components. The excessive vibrations of the OWT structure can impact the wind energy conversion to electricity, decrease the fatigue lifetime and even result in a total collapse of the structure when exposed to harsh environmental conditions. It is therefore important to reduce the unwanted vibrations of an OWT by implementing an appropriate control device that enhances its structural safety. Motivated by the potential of the structural control methods in suppressing OWTs vibration, this paper proposes the design of a controlled active tuned mass damper (ATMD) system to reduce the nacelle/tower out-of-plane vibration of a monopile-supported 10 MW DTU OWT subjected to combined wave and wind loads. Compared to previous works, the main originality of this paper is the inclusion of a state estimator, Linear Quadratic (LQ) observer, within an optimal control schema. The state observer aims to drastically reduce the number of required system states. Indeed, as some measurements are practically impossible, all system states cannot be obtained. In this study, a fully coupled multi-degree of freedom (MDOF) analytical model of a monopile-supported OWT developed in [4] is used for this purpose. The optimal control schema makes use of the robust LQR feedback controller to establish the ATMD actuator control force. The developed active control schema proved to efficiently reduce the nacelle/tower vibration.
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Qiang, Bin, and Xin Wang. "Determination of the Welding Residual Stresses in Welded Joints and Their Effects on SIFs for Surface Cracks: A Review of Recent Progress." In ASME 2021 40th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/omae2021-62310.
Abstract In this paper, the recent progress on the determination of welding residual stresses in Q345qD steel welded structural components and their effects on stress intensity factors for semi-elliptical surface cracks has been reviewed. Two different welded structural components: butt-welded steel plate and orthotropic steel deck (OSD) are considered. First, we summarize the results from recent studies on the experimental measurements and numerical simulations of the surface and through-thickness residual stress in the welded plate and OSD; the complete longitudinal and transverse residual stress distributions are discussed. Then, the effects of the obtained welding residual stresses on the SIFs for surface cracks in the weldments are quantified. The loading conditions considered are the combinations of service loading and residual stresses on the butt-welded plate and OSD. Semi-elliptical surface cracks with a wide range of aspect ratios and relative depths are investigated. In particular, both 3D FEA and weight function method are used for the determination of SIFs for surface cracks. The effects of welding residual stresses on SIFs are illustrated thoroughly. The current results are very important for the appropriate fatigue life assessment for welded structural components.
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Blouin, Arnaud, Stéphane Marie, Tomas Nicak, Antti Timperi, and Peter Gill. "Advanced Structural Integrity Assessment Tools for Safe Long Term Operation - ATLAS+ Project: Status of the Activities of the WP3 on Modelling in 2021." In ASME 2021 Pressure Vessels & Piping Conference. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/pvp2021-62010.
Abstract The main objective and mission of the ATLAS+ project is to develop advanced structural assessment tools to address the remaining technology gaps for the safe and long term operation of nuclear reactor pressure coolant boundary systems. ATLAS+ WP3 focuses mainly on ductile tearing prediction for large defects in piping and associated components: Several approaches have been developed to accurately model the ductile tearing process and to take into account phenomena such as triaxiality effects, or the ability to predict large tearing in industrial components. These advanced models include local approach coupled models or advanced energetic approaches. Unfortunately, the application of these tools is currently rather limited to R&D expertise. However, because of the continuous progress in the performance of calculation tools and accumulated knowledge, in particular by members of the ATLAS+ consortium, these models can now be considered as relevant for application in the context of engineering assessments. WP3 has been planned to: • Illustrate the implementation of these models for industrial applications through the interpretation of large scale mock-ups (with cracks in weld joints for some of them), • Make recommendations for the implementation of the advanced models in engineering assessments, • Correct data from the conventional engineering approach by developing a methodology to produce J-Δa curve suitable case by case, based on local approach models, • Improve the tools, guidance and procedures for undertaking leak-before-break (LBB) assessments of piping components, particularly in relation to representing structural representative fracture toughness J-Resistance curves and the influence of weld residual stresses. To achieve these goals, WP3 is divided into 4 sub-WPs. This paper presents the progress of the work performed in each sub-WP after 48 months of activities.
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Liu, Shuai, Xuan Huang, Zhipeng Feng, Xiaozhou Jiang, Bihao Wang, and Wanjun Wu. "Research on Numerical Calculation Model of Impact Load on Reef in Deep Sea." In ASME 2021 Pressure Vessels & Piping Conference. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/pvp2021-62110.
Abstract In the deep sea, one of the main threats to the structural safety of ships is the impact load caused by reef. This paper established a numerical calculation model which is suitable for simulating the impact load on reef in the deep sea. The model considers the coupling effects of large deformation, fluid-structure interaction, and material plastic deformation. The mesh size, material constitutive model and fluid structure coupling method are studied. The explicit dynamic analysis method is verified by the AISI experiment which there is little difference between the numerical simulation results and the experimental results. Based on the method, the model considering the effect of fluid-structure interaction (FSI) is established and the effectiveness of the FSI is verified by the theoretical results of the national military standard. Then, fluid structure interaction algorithm is studied. Finally, the model which is suitable for simulating the collision between ship and reef in deep sea is established. The effect of reef size and shape on the impact load was studied. It can be seen that the shape and size of the reef mainly affect the contact area and contact stiffness and have a great impact on the impact load. It can provide load input for the structural design of ship and ship equipments. In addition, the model has strong applicability and can be used to calculate the impact load in deep sea. However, the impact load caused by reef also depends on the material property of the ship and reefs condition of the navigation area.
