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1
Aranda Arribas, Victoria, and Rafael Bonilla Cerezo. "“En la república de los miopes”. Veintisiete notas a la Soledad primera de Góngora (II)." Nueva Revista de Filología Hispánica (NRFH) 71, no. 1 (January 1, 2023): 109–53. http://dx.doi.org/10.24201/nrfh.v71i1.3841.
Abstract:
El presente artículo procura arrojar luz sobre veintisiete loci critici de la Soledad primera (1613) de Góngora: vv. 117-120, 153-162, 167-168, 171-175, 182-189, 212-221, 263-266, 291-296, 321-328, 344-349, 374-375, 461-464, 500-502, 573-579, 580-584, 585-589, 598-601, 623-629, 667-668, 701-704, 705-708, 810-811, 812-817, 866-871, 872-878, 895-896, 943 y 1012-1013. A partir de la formidable edición de Robert Jammes (1994), releemos aquí un puñado de lugares de la silva de los campos acerca de los cuales el filólogo confesó que le asaltaban dudas. Acudimos para ello a los gongoristas antiguos (Almansa y Mendoza, Jáuregui, el Abad de Rute, Díaz de Rivas, el anónimo antequerano, Pellicer, Salcedo Coronel, Vázquez Siruela) y también a los modernos (Reyes, Spitzer, Alonso, Orozco, Pabst, Alatorre, Carreira, Sinicropi, Molho, Ly, Poggi, Cancelliere, Romanos, Sánchez Robayna, Lara Garrido, Yoshida, Blanco, Mazzocchi, Micó, Roses, Pérez Lasheras, Ponce Cárdenas, Collins, Tenorio, Matas Caballero, Chemris, Osuna Cabezas, Palomares, Castaldo, Román Gutiérrez, Tanabe, Rojas Castro, Conde, Sandoval...), sin orillar la tradición clásica, la emblemática y el diálogo con el resto del corpus poético de don Luis.
2
Pigny, Pascal, Catherine Bauters, Jean-Louis Wemeau, Martine Lecomte Houcke, Michel Crepin, Philippe Caron, Sophie Giraud, et al. "A Novel 9-Base Pair Duplication in RET Exon 8 in Familial Medullary Thyroid Carcinoma1." Journal of Clinical Endocrinology & Metabolism 84, no. 5 (May 1, 1999): 1700–1704. http://dx.doi.org/10.1210/jcem.84.5.5665.
Abstract:
Familial medullary thyroid carcinoma (FMTC) and multiple endocrine neoplasia type 2A syndromes are dominantly inherited diseases caused by activating germline mutations of the RET protooncogene. The majority of these patients carry a germline point mutation affecting one of five cysteine residues encoded by exon 10 (codon 609, 611, 618, or 620) or 11 (codon 634). In a few FMTC families, point mutations involving noncysteine codons in exon 13 (codons 768, 790, and 791), 14 (codon 804), or 15 (codon 891) have been reported. Hirschsprung’s disease is a nonneoplastic disorder associated with RET mutations leading to a loss of function effect. Mutations are identified in 50% of the familial cases and are scattered along the gene. We now report the study of a FMTC family with four affected members and a history of fatal neonatal intestinal obstruction in the sister of the proband. Genetic analysis demonstrated the absence of an usual FMTC mutation and the presence of a germline 9-bp duplication in RET exon 8 in the heterozygous state in all patients with MTC. This new mutation creates an additional cysteine residue in the extracellular cysteine-rich domain of RET. Further studies are warranted to confirm whether this new mutation is causing MTC only or could be associated with Hirschsprung’s disease.
3
Ferrari, Michelle K., Sameer M. Malhotra, John E. McNeal, and James D. Brooks. "842: Prognostic Significance of Vascular Invasion: A Long-Term Follow-Up of 621 Radical Prostatectomy Patients." Journal of Urology 171, no. 4S (April 2004): 222. http://dx.doi.org/10.1016/s0022-5347(18)38091-1.
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Bernhardt, Stephan, Marcus Hubbe, Michael Rink, Lothar Bergmann, Martin Boegemann, Michael Moran, Katrin Schlack, Arne Strauss, and Marianne Schmid. "Effect of comorbidities/comedications on treatment outcomes with sunitinib in patients (pts) with metastatic renal cell carcinoma (mRCC): Subgroup analyses from the STAR-TOR registry." Journal of Clinical Oncology 38, no. 6_suppl (February 20, 2020): 631. http://dx.doi.org/10.1200/jco.2020.38.6_suppl.631.
Abstract:
631 Background: Sunitinib remains an important treatment option for mRCC, but the effect of comorbidities/comedications on sunitinib treatment outcomes have not been fully explored. Methods: Data were collated from STAR-TOR, an ongoing real-world registry. Cutoff date for analysis was 19 June 2019. This subgroup analysis assessed the presence or absence of hypertension (HTN), and the use or non-use of statins and proton pump inhibitors (PPIs), determined at the time of entry to the registry. Treatment endpoints were overall survival (OS), progression-free survival (PFS) and objective response rate (ORR). OS and PFS were analyzed by Kaplan-Meier methods. Differences within subgroups were tested using Log-rank test for OS and PFS, and Fisher’s exact test for ORR. Results: 557 sunitinib-treated pts were analyzed; 366 had HTN and 191 did not, 130 used statins and 427 did not, and 165 used PPIs and 392 did not. Median (m) OS (95% confidence intervals) was similar in pts with and without HTN (25.4 [21.1, 31.5] vs 21.5 [15.2, 28.0] months; p = 0.215). mPFS (8.0 [6.5, 9.9] vs 6.3 [5.4, 8.2] months; p = 0.140) and ORR (31.2% vs 30.9%; p = 1.000) were also similar in pts with and without HTN. mOS was similar in pts who used statins vs those who did not (27.8 [20.2, 35.4] vs 24.0 [19.4, 27.3] months; p = 0.884), while mPFS was significantly longer in pts who used statins (9.4 [6.5, 13.6] vs 6.9 [5.7, 8.2] months; p = 0.044). ORR was 37.8% vs 29.0% in pts who did and did not use statins (p = 0.072). mOS was significantly shorter in pts who used PPIs vs those who did not (20.2 [14.9, 28.3] vs 25.7 [22.7, 33.0] months; p = 0.021). mPFS (5.8 [4.6, 8.2] vs 8.0 [6.5, 9.8] months; p = 0.091) and ORR (26.6% vs 33.0%; p = 0.177) were similar in pts who did and did not use PPIs. Conclusions: In sunitinib-treated pts with mRCC in a real-world registry, mPFS was significantly longer and there was a trend toward better ORR in pts who used statins, whereas mOS was significantly shorter and there was a trend toward shorter mPFS in pts who used PPIs. Common comedications may affect sunitinib treatment outcomes in pts with mRCC.
5
Zhang, Naidan, Chaixia Ji, Xiao Bao, Xinyin Peng, Maoju Tang, and Chengliang Yuan. "Uncovering potential new biomarkers and immune infiltration characteristics in primary Sjögren’s syndrome by integrated bioinformatics analysis." Medicine 102, no. 41 (October 13, 2023): e35534. http://dx.doi.org/10.1097/md.0000000000035534.
Abstract:
Primary Sjögren’s syndrome (pSS) is known as autoimmune disease characterized by damage to endocrine glands, such as the salivary and lacrimal glands. This study aimed to identify potential biomarkers for pSS using integrated bioinformatics analysis and explore the relationship between differentially expressed genes (DEGs) and immune infiltration. Three pSS datasets (GSE7451, GSE23117, and GSE40611) from the gene expression omnibus database were integrated. All the datasets were processed in R (version 4.0.3). A total of 16 immune cells and 13 immune functions were obtained. The top immune cell and immune function were “activated” dendritic cells and major histocompatibility complex class I. Correlation analysis showed the top correlation among 16 immune cells were B cells and tumor infiltrating lymphocytes, check-point and T cell co-stimulation, respectively. In comparisons of immune score, “activated” dendritic cells (.657 vs 594, P < .001), B cells (.492 vs 434, P = .004), macrophages (.631 vs 601, P = .010), inflammation-promoting (.545 vs 478, P < .001), Type I interferon Reponse (.728 vs 625, P < .001) and so on were higher in pSS than control group. In correlation analysis, the up-regulation of interferon induced protein with tetratricopeptide repeats 1 gene was strongly correlated with Type I interferon response with a correlation coefficient of .87. The receiver operating characteristic curve of 5 genes showed that the area under curve was.891. In the verification model, the area under curve was.881. In addition, disease ontology analysis supported the association between DEGs and pSS. In summary, pSS has a variety of DEGs in immune infiltration, which is worthy of the attention from clinicians.
6
Frank-Raue, K., H. Buhr, H. Dralle, E. Klar, N. Senninger, T. Weber, S. Rondot, W. Höppner, and F. Raue. "Long-term outcome in 46 gene carriers of hereditary medullary thyroid carcinoma after prophylactic thyroidectomy: impact of individual RET genotype." European Journal of Endocrinology 155, no. 2 (August 2006): 229–36. http://dx.doi.org/10.1530/eje.1.02216.
Abstract:
Objective: In children with RET proto-oncogene mutation, curative treatment of medullary thyroid carcinoma (MTC) is possible by prophylactic thyroidectomy. Recommendations on the timing and extent of thyroidectomy are based upon a model that utilises genotype–phenotype correlations to stratify mutations into three risk groups. Design: We evaluated the long-term outcome (mean follow-up 6.4 years, 15 patients more than 10 years, 26 patients more than 5 years) of operated gene carriers stratified into two risk groups (levels 1 and 2) based on the biological aggressiveness of MTC. Results: In 46 RET gene carriers, prophylactic thyroidectomy was carried out between the ages of 4 and 21 years. Level 1 mutations were harboured by 11 patients (codons 790, 791, 804 and 891). Histology was completely normal in two patients; in seven patients C-cell hyperplasia (CCH) and in two patients T1 tumours were diagnosed. All patients with level 1 mutations were cured. Level 2 mutations were harboured by 35 patients (codons 618, 620, 630 and 634). Histology of these patients showed CCH in 11 patients, T1 tumours in 21, T2 tumour in 1, T3 tumour in 1 and Tx in 1 patient. Histology showed no lymph node involvement. Five patients with level 2 mutations failed to be cured; in two patients, persistence of MTC was diagnosed directly after thyroidectomy and in three during follow-up. In two patients carrying a 634 mutation, other endocrinopathies (hyperparathyroidism and bilateral pheochromocytoma) manifested during follow-up. Conclusions: If prophylactic thyroidectomy is done at early ages, cure rate is high. Timing and extent of prophylactic thyroidectomy can be modified by individual RET mutation.
7
Bin Jalil, Mohd Ezwan, Mohamad Kamal A. Rahim, Noor Asmawati Samsuri, and Sunti Tuntrakool. "Multiple element of miniaturized printed log-periodic second series koch dipole array antenna for wideband chipless RFID tag reader." Indonesian Journal of Electrical Engineering and Computer Science 20, no. 2 (November 1, 2020): 887. http://dx.doi.org/10.11591/ijeecs.v20.i2.pp887-893.
Abstract:
This paper aims to produce a low profile, wideband, and high gain antenna for chipless RFID tag readers. A miniaturized and wideband printed Log-Periodic Second Series Koch Dipole Array (LPSSKDA) with eleven elements operating over 0.8 GHz-3.2 GHz is designed using the FR4 board. The single LPSSKDA antenna, which acts as the chipless RFID reader antenna having gain between 5.2 and 6.1 dBi and frequency range from 1-3 GHz. A double element of the LPSSKDA antenna is proposed for improving the antenna gain to 6.9-7.9 dBi over the frequency range. The antenna is fabricated to validate the simulation and measurement results in terms of reflection coefficient, radiation pattern, and surface current distribution.
8
Korchagina, A. A., E. K. Gladysheva, V. V. Budaeva, and E. A. Skiba. "Chemical composition of fiber and shive in bast-fiber crops and the products of their alkaline delignification." Proceedings of Universities. Applied Chemistry and Biotechnology 13, no. 4 (December 28, 2023): 621–30. http://dx.doi.org/10.21285/2227-2925-2023-13-4-621-630.
Abstract:
The present article examines the chemical composition of fiber and shive from fiber flax and hemp obtained in Russia under industrial conditions, as well as that of the products of their alkaline delignification. Alkaline delignification was carried out at atmospheric pressure with a 4% sodium hydroxide solution; the chemical composition was determined via wet analysis. The chemical composition of hemp shive from Russian producers was studied for the first time. In the studied objects, the mass fraction of cellulose was found to range from 42.3 to 66.1%, and after alkaline delignification, the yield of products reached 47.0–50.0%. The behavior of fiber flax and hemp fiber is similar during alkaline delignification: cellulose content increases by 1.2–1.3 times, pentosan content decreases by 4.3–6.3 times, and lignin content is virtually the same. The behavior of fiber flax and hemp shive is dramatically different during alkaline delignification. The shive of fiber flax is resistant to alkaline delignification: cellulose content increases by 1.4 times, pentosan content decreases by 4.2 times, and lignin content increases by 1.4 times, which is due to the nature of lignin. Hemp shive is easily alkaline delignified: cellulose content increases by 1.8 times; the content of pentosans decreases by 5.8 times, and lignin content decreases by 2.2 times; the product of alkaline delignification contains cellulose (87.3%), pentosans (5.4%), and lignin (8.2%). The use of hemp shive for chemical and biotechnological transformation is expected to have high prospects.
9
Al Ta'ani, Omar, Osama Abu-Shawer, Saja Jamil Abdelhadi, Murad Alkderat, Hala Sultan, Hebah Alshahwan, Diya' Maher Y. Safi, Ibrahim Abuelbeh, Mohannad Maher Y. Safi, and Maysa Al-Hussaini. "The predictive value of hematological markers in renal cell carcinoma." Journal of Clinical Oncology 41, no. 6_suppl (February 20, 2023): 621. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.621.
Abstract:
621 Background: Renal cell carcinoma (RCC), which accounts for about 3% of adult malignancies, is regarded as a major cause of morbidity and mortality. The neutrophil-lymphocyte ratio (NLR) is a simple, reliable, and cost-effective biomarker of systemic inflammation that has been linked to oncologic outcomes in a variety of malignancies. The objective of this study is to determine whether NLR, along with other hematological parameters such as absolute neutrophil count (ANC), absolute lymphocyte count (ALC), absolute eosinophil count (AEC), absolute monocyte count (AMC), monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), and the Systemic Immune-Inflammation Index (SII; defined as neutrophils counts X platelets counts divided by lymphocyte count), are related to baseline distant metastases and overall survival (OS) in RCC patients. Methods: Clinical data from 203 RCC patients treated at King Hussein Cancer Center (Amman, Jordan) were retrospectively reviewed. We examined the relationship between age, sex, ANC, AMC, ALC, AEC, NLR, MLR, PLR, and SII with baseline distant metastasis and patients’ OS. Results: Of the 203 patients, 97 patients (48.5%) were stage 4 at the time of diagnosis. Univariate analysis showed that patients with high baseline ANC (>5400), AMC (>600), AEC (>120), NLR (>4.36), MLR (>0.33), PLR (>140.44), WBC count (>8.2), SII (>757.7) and low baseline ALC (≤1900) had more baseline metastasis. (p-value: <0.001, 0.007, 0.020, <0.001, <0.001, <0.001, 0.006, <0.001, and 0.004, respectively). On multivariate analysis, patients who had elevated NLR (>4.36) were more likely to have distant metastasis at the time of diagnosis (p-value = 0.0076, odds ratio (OR): 4.45, CI: 1.49–13.33). Moreover, univariate and multivariate analysis showed that patients with elevated NLR (>4.36) were associated with poorer OS (p-value: <0.0001 and 0.0065, respectively). In addition, patients with elevated baseline ANC, AMC, MLR, PLR, SII, WBC count, and low ALC values were associated with poorer OS (p-value: <0.0001, 0.0234, <0.0001, <0.0001, <0.0001, 0.0290, and <0.0001, respectively). Conclusions: The results of this study indicate a substantial correlation between several hematological parameters, including NLR, with the presence of distant metastases at the time of diagnosis and OS. Further research is required to uncover whether these hematological markers may be used to identify patients who are more likely to develop metastases and predict treatment response.
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Herzog, Brett, Saiama Waqar, Siddhartha Devarakonda, Jeffrey Ward, Ramaswamy Govindan, and Daniel Morgensztern. "802 Ramucirumab plus atezolizumab in patients with stage IV non-small cell lung cancer previously treated with immune checkpoint blockade." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (November 2020): A851. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0802.
Abstract:
BackgroundT-cell trafficking to the tumor is inhibited via vascular endothelial growth factor (VEGF)-mediated down-regulation of important adhesion molecules on tumor-associated blood vessels and progression of disease on immune checkpoint blockers (ICBs) has been associated with decreased tumor-infiltrating immune cells.1 2 We hypothesized that inhibiting VEGF signaling through its receptor, VEGFR2, would increase intratumoral T cells. Therefore we sought to evaluate the combination of ramucirumab, an anti-VEGF receptor 2 monoclonal antibody, and atezolizumab in patients with advanced-stage, non-small cell lung cancer (NSCLC) patients who have previously progressed on at least one line of ICB. Here, we report on the first twelve patients enrolled on trial.MethodsAdvanced stage NSCLC patients with an ECOG performance status of ≤1 who had previously been treated with ICBs were eligible with no limitation on prior lines of ICB therapy. Patients with untreated brain metastasis, recent hemoptysis, gastrointestinal bleeding or perforation or fistula were excluded. The study was conducted with a two-stage MiniMax design. Peripheral blood and repeated biopsy, when feasible, were collected for correlative analysis.ResultsTwelve patients were enrolled in the first stage of the trial. The median age was 68 (range 47-78), 10 of the patients are female, and 10 had non-squamous histology. Patients had an average of 3.5 prior lines of therapy and 1.6 lines of prior immunotherapy. Overall, treatment was well-tolerated with no grade 3 or 4 adverse events. The most common adverse events were grade 1 or 2 hypertension (35%), nausea (25%) and vomiting (25%). There were no objective responses and 11 patients (91%) achieved stable disease. The median progression-free survival is 3 months with 3 patients (25%) on trial for more than 12 months. The median overall survival (OS) at the time of the latest data cutoff on 9/15/20 is 11.5 months.ConclusionsThe preliminary data from our study showed that combination of ramucirumab and atezolizumab is well-tolerated and associated with prolonged overall survival in a subset of heavily pretreated patients who progressed on prior ICB. The trial is still accruing patients and exploratory analyses are planned.Ethics ApprovalThe study was approved by the Washington University Institutional Review Board.ReferencesDirkx AE, oude Egbrink MG, Castermans K, et al. Anti-angiogenesis therapy can overcome endothelial cell anergy and promote leukocyte-endothelium interactions and infiltration in tumors. FASEB J 2006;20(6):621-630.Herbst RS, Soria JC, Kowanetz M, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 2014;515(7528):563-567.
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Schantz, Richard. "Michael P. LYNCH (ed.), The Nature of Truth. Classic and Contemporary Perspectives, The MIT Press, Cambridge, MA, London, 2001, xvi + 802 pp., ISBN 02-621-2239-1, € 62." Grazer Philosophische studien 67, no. 1 (August 12, 2004): 227–35. http://dx.doi.org/10.1163/18756735-90000831.
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Nemati, Nasrin, and Mohammad Bemani. "A novel reconfigurable microstrip fractal UWB antenna with six variable rejection frequency bands." International Journal of Microwave and Wireless Technologies 12, no. 2 (August 13, 2019): 148–54. http://dx.doi.org/10.1017/s1759078719001028.
Abstract:
AbstractIn this paper, a new reconfigurable microstrip fractal ultra-wideband antenna with a capability of variable rejection frequency bands is presented. The main patch of this antenna has two modified C-shaped gaps. Also, on these c-shaped gaps, 10 ideal MEMS switches are used to produce band-notch frequencies at six different frequencies of: 5.4 GHz (5.2–5.5), 5.8 GHz (5.7–5.9), 6.1 GHz (5.9–6.3), 7 GHz (6.9–7.2), 7.9 GHz (7.7–8.1), and 8.4 GHz (8.2–8.6). This antenna is fed by a 50 Ω microstrip line and works in a wide bandwidth of 2.9–11 GHz. The antenna is designed and fabricated on an inexpensive substrate of FR4. Dimensions of the antenna are 31.2 × 38.4 mm. Measurement and simulation results are in good agreement.
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Sulaksono, Andrea Sigit, and Edi Hamdi. "External And Internal Factors Analysis For “Mining Contractors Services Company” In Indonesia." Cakrawala Repositori IMWI 6, no. 5 (November 1, 2023): 1998–2008. http://dx.doi.org/10.52851/cakrawala.v6i5.514.
Abstract:
Background - Coal Production, The Ministry of Energy and Mineral Resources (ESDM) noted that Indonesia's coal production will reach 606.22 million tons in 2021 from the planned 625 million tons or 96.99%. An increase of 7.2% compared to 2020 of 565.69 million tones. Since 2014, coal production has shown an increasing trend. However, production declined in 2016 and 2020. In 2016, coal production fell 1.1%, while in 2020, production fell 8.2%. The Ministry of Energy and Mineral Resources estimates that Indonesia's coal production in 2022-2023 will increase in the range of 637 million tons to 664 million tons. Meanwhile, the demand for domestic coal (domestic market obligations/DMO) in 2021 is 63.47 million tons or 10% of total production has been realized. The figure decreased by 51.87% from 131.89 million tons in 2020.
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Hutchinson, W. L., P. G. Morris, and J. Mowbray. "The molecular structure of a rapidly formed oligomeric adenosine tetraphosphate derivative from rat heart." Biochemical Journal 234, no. 3 (March 15, 1986): 623–27. http://dx.doi.org/10.1042/bj2340623.
Abstract:
The inability to account for large systematic variations with time in soluble adenine nucleotides in perfused rat hearts [Bates, Perrett & Mowbray (1978) Biochem. J. 176, 485-493; Mowbray, Bates & Perrett (1981) FEBS Lett. 131, 55-59; Mowbray, Perrett & Bates (1984) Int. J. Biochem. 16, 889-894] led us to show that the soluble nucleotides are in rapid equilibrium with some hitherto unrecognized trichloroacetic acid/methanol-precipitable highly phosphorylated heteropolymeric form [Mowbray, Hutchinson, Tibbs & Morris (1984) Biochem. J. 223, 627-632]. Selective digestion coupled to chromatographic analysis together with m.s. and 31P-n.m.r. spectrometry have now been used to show that the likely structure for a purified oligomer that is in specific-radioactivity equilibrium with tissue ATP is 3-phospho-[glyceroyl-gamma-triphosphoroyl-5′-adenosine-3′-3- phospho]4 glyceroyl-gamma-triphosphoroyl-5′-adenosine.
15
Sultana, Mst Atia, Kh Shahnewaj, Md Saiful Islam, and Bimol Chandra Roy. "Relationship Between Peritoneal Closure At Primary Caesarian And Adhesion Formation" A Retrospective Observational Study And Personal Experience." KYAMC Journal 6, no. 2 (August 28, 2017): 627–30. http://dx.doi.org/10.3329/kyamcj.v6i2.33741.
Abstract:
The aim of this study was to find out the adhesion formation after closing of parietal peritoneum at primary caesarean section done in different indications; the patients were admitted in Khwaja Yunus Ali Medical College & Hospital, a rural tertiary hospital in Bangladesh. In this study total 872 pregnant women were evaluated in 4 years period, who were admitted either from OPD or through emergency. Most of the caesarean sections were done due to elective causes. After the primary caesarean section, the repeat caesarean section was done in the same hospital by same surgeon within these time period and observed that there was no or few filmy adhesions were formed. So it was evaluated that, objectively to accept this step that is peritoneal closure in our operation procedure to reduce peritoneal adhesion formation.KYAMC Journal Vol. 6, No.-2, Jan 2016, Page 627-630
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Santos-García, D., T. de Deus Fonticoba, E. Suárez Castro, A. Aneiros Díaz, and D. McAfee. "5-2-1 Criteria: A Simple Screening Tool for Identifying Advanced PD Patients Who Need an Optimization of Parkinson’s Treatment." Parkinson's Disease 2020 (March 24, 2020): 1–6. http://dx.doi.org/10.1155/2020/7537924.
Abstract:
Objective. 5- (5 times oral levodopa tablet taken/day) 2- (2 hours of OFF time/day) 1- (1 hour/day of troublesome dyskinesia) criteria have been proposed by a Delphi expert consensus panel for diagnosing advanced Parkinson’s disease (PD). The aim of the present study is to compare quality of life (QoL) in PD patients with “5-2-1 positive criteria” vs QoL in PD patients without “5-2-1 positive criteria” (defined as meeting ≥1 of the criteria). Methods. This is a cross-sectional, observational, monocenter study. Three different instruments were used to assess QoL: the 39-Item Parkinson’s Disease Quality of Life Questionnaire Summary Index Score (PDQ-39SI); a subjective rating of perceived QoL (PQ-10); and the EUROHIS-QOL 8-Item Index (EUROHIS-QOL8). Results. From a cohort of 102 PD patients (65.4 ± 8.2 years old, 53.9% males; disease duration 4.7 ± 4.5 years), 20 (19.6%) presented positive 5-2-1 criteria: 6.9% for 5, 17.6% for 2, and 4.9% for 1. 37.5% (12/32) and 25% (5/20) of patients with motor complications and dyskinesia, respectively, presented 5-2-1 negative criteria. Both health-related (PDQ-39SI, 25.6 ± 14 vs 12.1 ± 9.2; p<0.0001) and global QoL (PQ-10, 6.1 ± 2 vs 7.1 ± 1.3; p=0.007; EUROHIS-QOL8, 3.5 ± 0.5 vs 3.7 ± 0.4; p=0.034) were worse in patients with 5-2-1 positive criteria. Moreover, nonmotor symptoms burden (Non-Motor Symptoms Scale total score, 64.8 ± 44.8 vs 39.4 ± 35.1; p<0.0001) and autonomy for activities of daily living (ADLS scale, 73.5 ± 13.1 vs 89.2 ± 9.3; p<0.0001) were worse in patients with 5-2-1 positive criteria. Patient’s principal caregiver’s strain (Caregiver Stain Index, 4.3 ± 3 vs 1.5 ± 1.6; p<0.0001), burden (Zarit Caregiver Burden Inventory, 28.4 ± 12.5 vs 10.9 ± 9.8; p<0.0001), and mood (Beck Depression Inventory II, 12.2 ± 7.2 vs 6.2 ± 6.1; p<0.0001) were worse in patients with 5-2-1 positive criteria as well. Conclusions. QoL is worse in patients meeting ≥1 of the 5-2-1 criteria. This group of patients and their caregivers are more affected as a whole. These criteria could be useful for identifying patients in which it is necessary to optimize Parkinson’s treatment.
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Smagulova, Kaldigul. "Comparative analysis of the effectiveness of second-line bevacizumab plus chemotherapy in second-line therapy in metastatic colorectal cancer." Journal of Clinical Oncology 32, no. 3_suppl (January 20, 2014): 619. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.619.
Abstract:
619 Background: Advances in molecular biology and a wide introduction to the practice of targeted therapies have improved outcomes and significantly affect the overall survival of patients. To investigate the efficacy and safety of bevacizumab (BEV) beyond first progression combined with chemotherapy (CT) in patients with metastatic colorectal cancer. Methods: 68 patients with mCRC who received chemotherapy treatment at the Department of the Kazakh Research Institute of Oncology and Radiology. Selecting second-line chemotherapy based on oxaliplatin or irinotecan depended of an earlier first-line therapy (FOLFOX, FOLFIRI). The survival rate was calculated by Kaplan-Meier, comparison of survival curves was performed by log-rank. Results: The study included 68 patients, who were randomized from February 2009 to November 2011(to 33 [48.5%] BEV + CT and 35 [51.5%] to CT alone). Analysis of the immediate results of treatment showed that in neither case was not achieved complete response of the tumor. Partial regression in group 1 – 11 (33.3 ± 8.2)%, and group 2 - in 9 (25.7 ± 7.3)%. Stabilization is achieved in 20 (60.6 ± 8.5)% and 23 (6.7 ± 8.0)% of cases, respectively. The progression of the disease was observed in the group 1 in 2 (6.1 ± 4.1)% and 3 (8.6 ± 4.7)% of cases. Median progression-free survival (PFS) and overall survival (OS) was 11.5 months (7-16) and 12.2 months in group 1, and 9.7 months (6-13.2) (PFS), 9.1 months(OS) in group 2, respectively. The adverse event profile was consistent with previously reported data for BEV + CT. BEV-related significant adverse events included bleeding grade 3-4 (1.5 %) and venous thrombosis (2.3 %). Conclusions: Our findings demonstrate that BEV + CT continued beyond progression significantly prolong OS and PFS in second-line therapy mCRC.
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Ogawa, Kazuya, Joanne Dy, and Yoshiaki Kobuke. "Substituent effect on two-photon absorption properties of conjugated porphyrins." Journal of Porphyrins and Phthalocyanines 09, no. 10 (October 2005): 735–44. http://dx.doi.org/10.1142/s1088424605000848.
Abstract:
Two-photon absorption (2PA) cross section values of bisacetylene-connected bisporphyrins were measured by using a nanosecond open aperture Z-scan method. The maximum effective cross section values of alkyl and aryl meso-substituted bisporphyrins were 14,000 GM at 890 nm and 7,700 GM at 860 nm, respectively, and the value of alkyl-substituted bisporphyrin was almost twice of that of aryl-substituted one. In one-photon absorption spectra, Q-bands of alkyl-substituted bisporphyrin were red-shifted at 635 nm and 685 nm, and intensified compared with those of aryl-substituted one at 625 nm and 678 nm, respectively, indicating higher π-electron density of the former compound compared to that of the later. The large enhancement observed for alkyl-substituted bisporphyrin is attributed to the increase in π- electron density compared with aryl-substituted one. It was found that the alkyl group is better to obtain large 2PA cross section values than the aryl group as the meso-substituent of the porphyrin.
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Etzler, Sonja, Reinhard Eher, and Martin Rettenberger. "Dynamic Risk Assessment of Sexual Offenders: Validity and Dimensional Structure of the Stable-2007." Assessment 27, no. 4 (February 6, 2018): 822–39. http://dx.doi.org/10.1177/1073191118754705.
Abstract:
In this study, the predictive and incremental validity of the Stable-2007 beyond the Static-99 was evaluated in an updated sample of N = 638 adult male sexual offenders followed-up for an average of M = 8.2 years. Data were collected at the Federal Evaluation Center for Violent and Sexual Offenders (FECVSO) in Austria within a prospective-longitudinal research design. Scores and risk categories of the Static-99 (AUC = .721; p < .001) and of the Stable-2007 (AUC = .623, p = .005) were found to be significantly related to sexual recidivism. The Stable-2007 risk categories contributed incrementally to the prediction of sexual recidivism beyond the Static-99. Analyzing the dimensional structure of the Stable-2007 yielded three factors, named Antisociality, Sexual Deviance, and Hypersexuality. Antisociality and Sexual Deviance were significant predictors for sexual recidivism. Sexual Deviance was negatively associated with non-sexual violent recidivism. Comparisons with latent dimensions of other risk assessment instruments are made and implications for applied risk assessment are discussed.
20
Benseñor, Isabela M., Alessandra Carvalho Goulart, Paulo A. Lotufo, Paulo Rossi Menezes, and Marcia Scazufca. "Prevalence of thyroid disorders among older people: results from the São Paulo Ageing & Health Study." Cadernos de Saúde Pública 27, no. 1 (January 2011): 155–61. http://dx.doi.org/10.1590/s0102-311x2011000100016.
Abstract:
This study aimed to estimate prevalence of thyroid disorders in the São Paulo Ageing & Health Study, an epidemiological study addressing several health-adverse outcomes among elderly people living in a poor area of São Paulo, Brazil. All participants answered a questionnaire and had a blood sample collected to assess levels of tireotropic hormone and free-thyroxine. Among 1,373 people (60.8% women), prevalence rates (95% confidence interval) for thyroid dysfunction (%) were: overt hyperthyroidism, 0.7% (0.2-1.1)[women: 0.8% (0.2-1.5); men: 0.4% (0.01-0.9)]; overt hypothyroidism, 5.7% (4.5-6.9) [women: 5.9% (4.3-7.5); men: 5.4% (3.5-7.3)]; subclinical hyperthyroidism, 2.4% (1.6-3.2) [women: 2.8% (1.6-3.9); men: 1.9% (0.7-3.0)]; and subclinical hypothyroidism, 6.5% (5.2-7.8) [women: 6.7% (5.0-8.4); men: 6.1% (4.1-8.2)]. There was no difference in prevalence rates according to gender, but almost 40% of women were diagnosed and under treatment compared to 9% of men. The burden of thyroid disorders in this sample is high and most participants were not aware of them.
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BASS, Mark D., Beverley J. SMITH, Sally A. PRIGENT, and David R. CRITCHLEY. "Talin contains three similar vinculin-binding sites predicted to form an amphipathic helix." Biochemical Journal 341, no. 2 (July 8, 1999): 257–63. http://dx.doi.org/10.1042/bj3410257.
Abstract:
Using recombinant talin polypeptides and an SDS/PAGE-blot overlay assay, we have previously identified three regions of talin that are involved in binding to vinculin [Gilmore, Wood, Ohanian, Jackson, Patel, Rees, Hynes and Critchley (1993) J. Cell Biol. 122, 337-347]. We have confirmed these observations by using a yeast two-hybrid assay and shown that talin residues 498-656, 852-950 and 1929-2029 are each capable of binding to vinculin residues 1-258. We have further defined the three vinculin-binding sites in talin to residues 607-636, 852-876 and 1944-1969; alignment of these sequences shows 59% similarity, although there are only two identical residues. Predictions of secondary structure indicate that this vinculin-binding motif forms an amphipathic α-helix. The hydrophobic face of helix 607-636 contains three aligned leucines (residues 608, 615 and 622), which show conservative substitutions in the other two sites. To test the possibility that this might constitute a leucine zipper involved in vinculin binding, we mutated each leucine residue to an alanine. The results showed that this leucine repeat is not essential to the interaction between talin and vinculin. We also used the yeast two-hybrid system to define further the talin-binding site within vinculin residues 1-258. C-terminal deletions made in accordance with exon boundaries showed that vinculin residues 1-167 are capable of interacting with each of the three vinculin-binding sites in talin. However, all N-terminal deletions abolished binding. The results suggest that the talin-binding site in vinculin has a relatively complex fold, whereas the vinculin-binding motif in talin is contained within a short linear peptide sequence that is repeated three times in the talin rod domain.
22
Murray, Maeve P., Catherine J. Doherty, John R. W. Govan, and Adam T. Hill. "Do processing time and storage of sputum influence quantitative bacteriology in bronchiectasis?" Journal of Medical Microbiology 59, no. 7 (July 1, 2010): 829–33. http://dx.doi.org/10.1099/jmm.0.016683-0.
Abstract:
This study aimed to establish whether the bacterial density of spontaneous sputum is affected by the time and mode of sample storage. Ten patients with bronchiectasis collected all sputum expectorated over 45 min. The samples were aliquoted and processed at 25 °C for qualitative and quantitative bacteriology at 1, 2, 4 and 6 h from expectoration. Further aliquots were stored at 25 °C, 4 °C and −20 °C for 24 and 48 h prior to processing. The species present was identified and median (interquartile range) sputum log10 bacterial density (c.f.u. ml−1) calculated. All samples cultured grew Pseudomonas aeruginosa and for two patients Staphylococcus aureus additionally grew for all samples. There was no significant difference in P. aeruginosa density in samples processed at 1, 2, 4 and 6 h following expectoration [8.2 (7.8–8.3) c.f.u. ml−1, 8.0 (7.8–8.3) c.f.u. ml−1, 8.0 (7.9–8.2) c.f.u. ml−1, 8.1 (7.9–8.2) c.f.u. ml−1, respectively, P=0.392]. Storage for 24 and 48 h at 4 °C did not significantly change the bacterial load compared with processing at 1 h [8.03 (7.6–8.2) c.f.u. ml−1, P=0.07, and 7.96 (7.49–8.22) c.f.u. ml−1, P=0.09, respectively]. Storage for 24 and 48 h at −20 °C significantly reduced P. aeruginosa density [7.1 (6.1–7.7) c.f.u. ml−1, P=0.005, and 6.9 (6.2–7.6) c.f.u. ml−1, P=0.008, respectively]. Storage at 25 °C for 24 and 48 h was associated with a significant increase in bacterial load [8.3 (8.1–8.6) c.f.u. ml−1, P=0.009, and 8.4 (8.1–8.5) c.f.u. ml−1, P=0.03, respectively]. Bacterial density was not affected by storage for up to 6 h following expectoration at 25 °C; beyond this, storage at 4 °C is preferred.
23
Kaur, Harwinder, and Hari Ram. "Nitrogen management of wheat cultivars for higher productivity - A review." Journal of Applied and Natural Science 9, no. 1 (March 1, 2017): 133–43. http://dx.doi.org/10.31018/jans.v9i1.1161.
Abstract:
The increased population pressure has led to the maximum use of chemical fertilizers especially in the major crops such as rice, wheat and maize production. India has an ever growing population needing food and also the growing urban middle class with higher standards of living is on the lookout for better quality product. The introduction of improved seeds increases the utility of traditional inputs and their consumption as well. Because of genetic variation, BVC 223, Qingnong 8, IPA99, CT 01217, Luomai 8, Seher 06, Sistan, Punjab 2011, Rasco 2005, PBW 343, Halna, HP 1744, VL Gehun 892, WH 1022, PBW 621, and PBW 550 cultivars of wheat crop differ in growth and development behaviour and respond higher to different nitrogen management practices. However, ever increasing prices of Nitrogen (N) fertilizers and possibilities of environmental pollution and groundwater contamination warn for their judicious and efficient use. The application of essential plant nutrients particularly N nutrient in optimum quantity (120-150 kg/ha) and right proportion (3-4 splits) through correct methods and time of application (LCC and green seeker based) is the key to increased and sustained crop production. The increase in quality due to nitrogen fertilization (120-330 kg/ha) may be due to its role in activation of cells division, metabolic and photosynthesis process and nutritive status of wheat plant. Keeping in view above all facts in mind, performance of wheat cultivars as influenced by different nitrogen rates will be discussed in this review.
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Krupa, Michał. "Notki recenzyjne." Z Badań nad Książką i Księgozbiorami Historycznymi 10 (December 11, 2019): 397–410. http://dx.doi.org/10.33077/uw.25448730.zbkh.2016.131.
Abstract:
Pamiętniki i relacje w zbiorach rękopiśmiennych BN (wydanie drugie poprawione i rozszerzone), oprac. Danuta Kamolowa przy współudziale Teresy Sieniateckiej, Warszawa: Biblioteka Narodowa, 2015, 539, [1] s., [26] k. tabl.: il., ISBN 978-83-7009-623-6 – Katarzyna Seroka [397-398]
Anna Kocot, Artyści „czarnej sztuki”. Typografia druków Floriana Unglera i Macieja Wirzbięty, Kraków: Księgarnia Akademicka, 2015, ss. 416, ISBN/ISSN 978-83-76384-60-3 – Anna Kamler [398-403]
Justyna Kiliańczyk-Zięba, Sygnety drukarskie w Rzeczypospolitej XVI wieku: źródła ikonografi czne i treści ideowe, Kraków: Wydawnictwo Towarzystwa Naukowego „SocietasVistulana”, 2015, ss. 342, [1]: il., ISBN 978-83-61033-89-9 – Katarzyna Seroka [403-405]
Catalogue of books from the Library of Sigismund II Augustus, King of Poland, in the collection of the National Library of Russia in Saint Petersburg, ed. by Maria I. Tkachenko, Maria Brynda, National Library of Poland (Warsaw), National Library of Russia (Saint Petersburg),Warsaw: National Library of Poland, 2015, 198 [1] s., [21] s. tabl., ISBN 978-83-7009-621-2 – Karolina Figaszewska [405-406]
Joanna Matyasik, Polonika XVI-XVII w. ze zbiorów Wojewódzkiej i Miejskiej Biblioteki Publicznej w Bydgoszczy. Katalog, Bydgoszcz: Wojewódzka i Miejska Biblioteka Publiczna im. Dr. Witolda Bełzy, 2015, ss. 345, ISBN 978-83-85979-21-0; 978-83-62545-86-5 – Agnieszka Chamera-Nowak [406-409]
Polski wkład w przyrodoznawstwo i technikę: słownik polskich i związanych z Polską odkrywców, wynalazców oraz pionierów nauk matematycznoprzyrodniczych i techniki, t. 1-4, red. nauk. Bolesław Orłowski, Warszawa: Instytut Historii Nauki im. Ludwika i Aleksandra Birkenmajerów Polskiej Akademii Nauk, Instytut Pamięci Narodowej – Komisja Ścigania Zbrodni przeciwko Narodowi Polskiemu, 2015, t. 1 ss. 521, t. 2 ss. 437, t. 3 ss. 511, t. 4 ss. 543, ISBN 978-83-8606-229-4; 978-83-8606-228-7; 978-83-7629-829-0; 978-83-7629-828-3; 978-83-7545-569-4; 978-83-7545-570-0 – Sarah Skumanov [409-410]
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Elalfy, Mohsen Saleh, and Iman Abdin. "Liver Status in a Cohort of Polytransfused B-Thalassemia Major (BTM) on Long Term Desferrioxamine (DfO) or Deferiprone (L1)." Blood 108, no. 11 (November 16, 2006): 3732. http://dx.doi.org/10.1182/blood.v108.11.3732.3732.
Abstract:
Abstract The liver is the main body site for iron storage. Iron chelators as DFo and L1 had problems of compliance and intolerance respectively. This prospective study enrolled 76 BTM patients aged from 9–33 years, mean of 14±4.4 to evaluate the effectiveness of both chelators judged by serum ferritin (sf) and liver iron content (LIC) using repeated liver biopsies. Fifty patients were on DFo 35 mg/kg/day 5 days per week and twenty-six were on L1 75 mg/kg/day on daily bases. Mean baseline sf values were 3678±1922 and 3573±1879 ng/ml while mean baseline LIC was 19.2±7.9 and 18.9±8.1 mg fe/g dw, while 12% and 14% showed evidence of liver fibrosis (score ≥ 3) respectively. Twenty-four months later; a decline in sf by 287±837 in Dfo (In Dfo compliant group [number = 30]who had received ≥ 75% of planned dose; sf dropped by 890±437 while increased in DFo non compliant by 621±513). While falling by 729±633 in L1 group. A decrease in LIC by 3.9±2.8 mg fe/g dw (−5.8±3.1 in Dfo compliant,+2.6±3.3 in Dfo non compliant) and falling by 2.2±3.4 mg fe/g dw in L1 group, the difference was statistically significant P< 0.05 between compliant and non compliant DFo and insignificant difference between Dfo and L1.The mean iron excretion: intake was 1.61,0.86 and 1.48 in Dfo compliant, non compliant and L1 respectively. A positive correlation was found between sf and LIC in both groups. Fibrosis was improved in Dfo compliant group better than L1 but no statistically significant difference was observed, while progressive fibrosis in 10% of Dfo non compliant group. All Dfo compliant group completed study, 18 out of 20 Dfo non compliant while six L1 patients discontinued the drug prematurely (3 severe gastrointestinal disturbances, 2 severe arthralgia and one repeated neutropenia). Conclusion: Both Dfo and L1 are effective iron chelators evident by drop in sf, LIC and improved fibrosis, however compliance and intolerance are still troublesome.
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Navari, Rudolph M., Gary Binder, Erminio Bonizzoni, Rebecca Clark-Snow, Silvia Olivari, and Eric J. Roeland. "Single-dose netupitant/palonosetron versus 3-day aprepitant for preventing chemotherapy-induced nausea and vomiting: a pooled analysis." Future Oncology 17, no. 23 (August 2021): 3027–35. http://dx.doi.org/10.2217/fon-2021-0023.
Abstract:
Aim: In the absence of comparative studies, guidelines consider neurokinin 1 receptor antagonists (RAs) as interchangeable. We evaluated the pooled efficacy from three cisplatin registration trials, each with arms containing netupitant/palonosetron (NEPA), a fixed neurokinin 1 RA (netupitant)/serotonin Type 3 (5-HT3) RA (palonosetron) combination, and an aprepitant (APR) regimen. Materials & methods: Efficacy data were pooled for rates of complete response (CR: no emesis/no rescue medication), complete protection (CR + no significant nausea), total control (CR + no nausea) and no significant nausea during acute (0–24 h), delayed (>24–120 h) and overall (0–120 h) phases post chemotherapy. Results: Among 621 NEPA and 576 APR patients, response rates were similar for the acute phase, and generally favored NEPA during delayed and overall phases. CR rates for NEPA versus APR were 88.4 versus 89.2%, 81.8 versus 76.9% (p < 0.05) and 78.4 versus 75.0% during the acute, delayed and overall phases, respectively. Conclusion: Oral NEPA administered on day 1 was more effective than a 3-day APR regimen in preventing delayed nausea and vomiting associated with cisplatin.
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Shivaji, Sisinthy, and Gundlapally Sathyanarayana Reddy. "Phylogenetic analyses of the genus Glaciecola: emended description of the genus Glaciecola, transfer of Glaciecola mesophila, G. agarilytica, G. aquimarina, G. arctica, G. chathamensis, G. polaris and G. psychrophila to the genus Paraglaciecola gen. nov. as Paraglaciecola mesophila comb. nov., P. agarilytica comb. nov., P. aquimarina comb. nov., P. arctica comb. nov., P. chathamensis comb. nov., P. polaris comb. nov. and P. psychrophila comb. nov., and description of Paraglaciecola oceanifecundans sp. nov., isolated from the Southern Ocean." International Journal of Systematic and Evolutionary Microbiology 64, Pt_9 (September 1, 2014): 3264–75. http://dx.doi.org/10.1099/ijs.0.065409-0.
Abstract:
Phylogenetic analyses of the genus Glaciecola were performed using the sequences of the 16S rRNA gene and the GyrB protein to establish its taxonomic status. The results indicated a consistent clustering of the genus Glaciecola into two clades, with significant bootstrap values, with all the phylogenetic methods employed. Clade 1 was represented by seven species, Glaciecola agarilytica , G. aquimarina , G. arctica , G. chathamensis , G. mesophila , G. polaris and G. psychrophila , while clade 2 consisted of only three species, Glaciecola nitratireducens , G. pallidula and G. punicea . Evolutionary distances between species of clades 1 and 2, based on 16S rRNA gene and GyrB protein sequences, ranged from 93.0 to 95.0 % and 69.0 to 73.0 %, respectively. In addition, clades 1 and 2 possessed 18 unique signature nucleotides, at positions 132, 184 : 193, 185 : 192, 230, 616 : 624, 631, 632, 633, 738, 829, 1257, 1265, 1281, 1356 and 1366, in the 16S rRNA gene sequence and can be differentiated by the occurrence of a 15 nt signature motif 5′-CAAATCAGAATGTTG at positions 1354–1368 in members of clade 2. Robust clustering of the genus Glaciecola into two clades based on analysis of 16S rRNA gene and GyrB protein sequences, 16S rRNA gene sequence similarity of ≤95.0 % and the occurrence of signature nucleotides and signature motifs in the 16S rRNA gene suggested that the genus should be split into two genera. The genus Paraglaciecola gen. nov. is therefore created to accommodate the seven species of clade 1, while the name Glaciecola sensu stricto is retained to represent species of clade 2. The species of clade 1 are transferred to the genus Paraglaciecola as Paraglaciecola mesophila comb. nov. (type strain DSM 15026T = KMM 241T), P. agarilytica comb. nov. (type strain NO2T = KCTC 12755T = LMG 23762T), P. aquimarina comb. nov. (type strain GGW-M5T = KCTC 32108T = CCUG 62918T), P. arctica comb. nov. (type strain BSs20135T = CCTCC AB 209161T = KACC 14537T), P. chathamensis comb. nov. (type strain E3T = CGMCC 1.7001T = JCM 15139T), P. polaris comb. nov. (type strain ARK 150T = CIP 108324T = LMG 21857T) and P. psychrophila comb. nov. (type strain 170T = CGMCC1.6130T = JCM 13954T). The type species of the genus Paraglaciecola is Paraglaciecola mesophila. An emended description of the genus Glaciecola is provided. In addition, a novel strain, 162Z-12T, was isolated from seawater collected as part of an iron fertilization experiment (LOHAFEX) conducted in the Southern Ocean in 2009 and was subjected to polyphasic taxonomic characterization. Cells of 162Z-12T were Gram-negative, aerobic, motile, ovoid to short rod-shaped, obligatorily halophilic and possessed all the characteristics of the genus Paraglaciecola. Strain 162Z-12T shared the highest 16S rRNA gene sequence similarity with the type strains of P. agarilytica (99.7 %), P. chathamensis (99.7 %), P. mesophila (98.5 %) and P. polaris (98.3 %). However, it exhibited DNA–DNA relatedness of less than 70.0 % with its nearest phylogenetic relatives, well below the threshold value for species delineation. Further, strain 162Z-12T differed from the nearest species in several phenotypic characteristics, in addition to the occurrence of unique nucleotides G, T, T and T at positions 1194, 1269, 1270 and 1271 of the 16S rRNA gene. Based on the cumulative differences it exhibited from its nearest phylogenetic neighbours, strain 162Z-12T was identified as a novel member of the genus Paraglaciecola and assigned to the novel species Paraglaciecola oceanifecundans sp. nov. The type strain of Paraglaciecola oceanifecundans is 162Z-12T ( = KCTC 32337T = LMG 27453T).
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Jones, Robin, Jonathan Phillips, and Michalis Panteli. "INCIDENTAL FINDINGS AND CLINICAL SIGNIFICANCE OF PREOPERATIVE CT IMAGING FOR THE PLANNING OF ROBOTIC ARTHROPLASTY." Orthopaedic Proceedings 105-B, SUPP_13 (August 7, 2023): 82. http://dx.doi.org/10.1302/1358-992x.2023.13.082.
Abstract:
AbstractIntroductionTotal joint arthroplasty (TJA) is one of the commonest and most successful orthopaedic procedures, used for the management of end-stage arthritis. With the recent introduction of robotic assisted joint replacement, Computed Tomography (CT) has become part of required pre-operative planning.The aim of this study is to quantify and characterise incidental CT findings, their clinical significance, and their effect on planned joint arthroplasty.MethodologyAll consecutive patients undergoing an elective TJR (hip or knee arthroplasty) were retrospectively identified, over a 3-year period (December 2019 and December 2022). Data documented and analysed included patient demographics, type of joint arthroplasty, CT findings, their clinical significance, as well as potential delays to the planned arthroplasty because of these findings and subsequent further investigation.ResultsA total of 624 patients (637 studies, 323 (51.8%) female, 301 (48.2%) male) were identified of which 163 (25.6%) showed incidental findings within the long bones or pelvis. Of these 52 (8.2%) were significant, potentially requiring further management, 32 (5.0%) represented potential malignancy and 4 (0.6%) resulted in a new cancer diagnosis.ConclusionIt is not currently national standard practice to report planning CT imaging as it is deemed an unnecessary expense and burden on radiology services. Within the study cohort 52 (8.2%) of patients had a significant incidental finding that required further investigation or management and 4 (0.6%) had a previously undiagnosed malignancy. In order to avoid the inevitability of a missed malignancy on a planning CT, we must advocate for formal reports in all cases.
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Garbarino, James, Robert John Zagar, Brad Randmark, Ishup Singh, Joseph Kovach, Emma Cenzon, Michael Benko, Steve Tippins, Kenneth G. Busch, and Rohit Baghel. "16-Questions to Find Mass-Murderers, Spree-Shooters, Domestic-Terrorists, and a Study-1 of 232-School-Shooters with Controls and a Study-2 of 6-Teen-Shooters With 11-Homicidal and 12-Control Youth Rated with Ask Standard Predictor (ASP) of Violence Potential-Youth Version and the MMPI-A: Implications: Use Computer-Tests and Machine-Learning-Equations to Lower Insurance-Premiums and Prevent Church-Bankruptcy from Violent Offenses." Review of European Studies 14, no. 2 (May 17, 2022): 115. http://dx.doi.org/10.5539/res.v14n2p115.
Abstract:
630 Domestic-Terrorist-Mass-Murdering-Spree-Shooters are compared with 623-controls and separated by16-Questions with significant a=.846, p<.01, AUC=.704, p<.01 that are: (1) homicidal? (2) suicidal? (3) stressful-life-event? (4) handgun-many-weapons-access? (5) violence-planning-preparing? (6) revenge-motive? (7) eliciting-others-concern? (8) intent-leakage? (9) criminal-misconduct-history? (10) personal-grievance? (11) random-violent-behavior? (12) threatening-victims? (13) dead-male-victim? (14) targeting-person-school-or-work? (15) student-professional-work-relationship? and (15) student? Before the killing, terrorists come twice to courts, doctors, schools and human resources and are not diagnosed as dangerous. In Study-1: [from 1936-2019] 232-school-shooters are contrasted with 232-controls resulting in 414-dead, 832-injured, and 68-suicides (29%) which are analyzed with logistic-regression, F= 227.14, p<.01, df=8/455, R=.894, p<.01, R2=.8, p<.01, and separated with 8-Questions: (1) student? (2) suicidal? (3) stressful-life-event? (4) homicidal? (5) violence-planning-preparing? (6) personal-grievance? (7) handgun-access? and (8) targeting-person(s)? In Study-2: 6-teen-shooters with 11-homicidal and 12-controls are contrasted with the Ask-Standard-Predictor [ASP] Violence-Potential, Youth-Version (54-questions, a=.61, p<.01, AUC=.91, p<.01, rtest-retest=.75, p<.01, F=123.09, p<.01, and the Minnesota Multiphasic Personality Inventory Adolescent Version [MMPI-A (468-questions):], ANOVA-F=17.22, p<.01, Lie, F=33.91, Depression, F=26.18, p<.01, Psychopathic-Deviate, F=57.45, p<.01,Paranoia, F=23.92, p<.01, Schizophrenia, F=21.69, p<.01, MacAndrews Alcohol, F=16.84, p<.01, Addiction Admission, F= 38.88, p<.01, resulting in a “7-point-violence-profile,”found over 95 yrs. in 212-studies .(N=320,051). The expense side includes 2 examples. 1st, School-shooter insurance-industry higher-premiums from (1936-2019) resulted in [414-dead @ $3,834,988.08=$1,587,685,065.12] + [832-injured @ $33,773.52=$28,099,568.64]+[232-shooters@$3,834,988.08=$889,717,234.60]+[$2,505,501,868.32x1.3= $3,257,152,428.82] =a high cost of $5,762,654,297.14]. With no-computer-tests-equations from 2020-2106, ($5,762,654,297.14x2= [the expense will double to] $11,525,308,594.27, 828-dead, 1,664-injured. The 2nd violence example is the U.S-Catholic-Church-pedophilia-loss, (1936-2107) [payouts, $17,435,353,000] + [lost-donations =1.3 x payouts=] 22,665,958,900=$40,101,511,900(1986-2107), with 5,679 victims increasing (1936-2107) to 39,753-victims.
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Xu, Kai, Yan Wang, and Qiang Li. "Critical Cooling Rate for the Glass Formation of Fe80-XCoxP13C7 Alloy." Materials Science Forum 745-746 (February 2013): 799–808. http://dx.doi.org/10.4028/www.scientific.net/msf.745-746.799.
Abstract:
In this work, the critical cooling rate Rc for glass formation of a series of Fe80-xCoxP13C7 (x = 0, 5, 10, 15, 20 at.%) alloys was determined by means of constructing CCT curves using Uhlmanns method. The calculated critical cooling rates for x = 0, 5, 10, 15, 20 at.% are 621, 441, 548, 894, 922 K/s, respectively. These results well coincide with the maximum diameters of Fe80-xCoxP13C7 amorphous alloys determined by experiments varying with the content of Co. The calculated Rc was also on the reasonable order of magnitudes. In addition, the values of three common GFA criterions of Trg, ΔTx and γ were calculated according to the thermodynamic data determined from DSC and DTA curves of Fe80-xCoxP13C7 (x = 0, 5, 10, 15, 20 at.%) bulk amorphous alloy. The validity of these GFA criterions in the series of Fe80-xCoxP13C7 (x = 0, 5, 10, 15, 20 at.%) alloys were investigated and it was pointed out that these three GFA criterions were not able to explain the experimental results of the maximum diameters of Fe80-xCoxP13C7 amorphous alloys varying with the content x of Co.
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Armin, Shahnaz, Fatemeh Fallah, Abdollah Karimi, Fereshteh Karbasiyan, Masoud Alebouyeh, Sedigheh Rafiei Tabatabaei, Maryam Rajabnejad, et al. "Antibiotic Susceptibility Patterns for Carbapenem-Resistant Enterobacteriaceae." International Journal of Microbiology 2023 (February 20, 2023): 1–5. http://dx.doi.org/10.1155/2023/8920977.
Abstract:
Carbapenem is a broad-spectrum beta-lactam antibiotic considered the last choice for the treatment of antibiotic-resistant Gram-negative bacteria. Thus, the increasing rate of carbapenem resistance (CR) in Enterobacteriaceae is an urgent public health threat. This study aimed to evaluate the antibiotic susceptibility pattern of carbapenem-resistant Enterobacteriaceae (CRE) to new and old antibiotics. In this study, Klebsiella pneumoniae, E. coli, and Enterobacter spp. were collected from 10 hospitals in Iran for one year. CRE is recognized by resistance to meropenem and/or imipenem disk after identification of the collected bacteria. Antibiotic susceptibility of CRE against fosfomycin, rifampin, metronidazole, tigecycline, and aztreonam was detected by disk diffusion method and colistin by MIC. In this study, 1222 E. coli, 696 K. pneumoniae, and 621 Enterobacter spp. were collected from 10 hospitals in Iran in one year. Fifty-four E. coli (4.4%), 84 K. pneumoniae (12%), and 51 Enterobacter spp. (8.2%) were CRE. All CRE strains were resistant to metronidazole and rifampicin. Tigecycline has the highest sensitivity on CRE and levofloxacin for Enterobacter spp. Tigecycline showed an acceptable effectiveness rate of sensitivity on the CRE strain. Therefore, we suggest that clinicians consider this valuable antibiotic to treat CRE.
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Indriwati, Ratna Lukita, and Fatin Fadhilah Hasib. "The Role of Islamic Family Financial Planning on Fishermen in Sidoarjo Regency." Jurnal Ekonomi Syariah Teori dan Terapan 9, no. 6 (November 30, 2022): 850–62. http://dx.doi.org/10.20473/vol9iss20226pp850-862.
Abstract:
ABSTRAK Tujuan Penelitian ini adalah untuk menganalisis peran dari Perencanaan Keuangan Keluarga Islam pada Nelayan di Kabupaten Sidoarjo. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi kasus deskriptif. Data dikumpulkan melalui observasi, wawancara, dan dokumentasi. Kemudian, validasi data dengan triangulasi data. Hasil Penelitian ini menjelaskan bahwa adanya peran dari Perencanaan Keuangan Keluarga Islami pada Nelayan di Kabupaten Sidoarjo dalam mewujudkan kesejahteraan dengan sampel 4 orang nelayan yang direkomendasikan oleh pihak Dinas Perikanan Kabupaten Sidoarjo. Konsep yang digunakan untuk meneliti yakni; Konsep Generasi Kekayaan, Konsep Pemurnian Kekayaan, Konsep Perlindungan Kekayaan, Konsep Akumulasi Kekayaan, dan Konsep Distribusi Kekayaan. Temuan dari Penelitian ini bahwa dari keempat informan nelayan memiliki lebih banyak aset daripada hutang selain itu juga keempat informan nelayan telah mempersiapkan kemungkinan-kemungkinan buruk yang akan terjadi dimasa datang. Sehingga dapat disimpulkan perencanaan keuangan keluarga memiliki peran penting yang dapat membantu seseorang tersebut dalam mewujudkan kesejahteraan. Hal ini dibuktikan dengan kemampuan mengakumulasi yang mana jumlah aset yang dimiliki lebih besar dari hutang, sehingga terdapat kebebasan keuangan pada seseorang tersebut. Kata Kunci: Perencanaan Keuangan Keluarga Islami, Nelayan, Kabupaten Sidoarjo. ABSTRACT This study aimed to analyze the role of Islamic family financial planning for fishermen in Sidoarjo district. This research used a qualitative approach with a descriptive case study method. Data were collected through observation, interviews and documentation. Then, the data was validated with data triangulation. The results of this study explained that Islamic Family Financial Planning played a role for Fishermen in Sidoarjo Regency in realizing prosperity. The study's sample was four fishermen recommended by the Fisheries Office of Sidoarjo Regency. The concept used to research namely; Wealth Generation Concept, Wealth Purification Concept, Wealth Protection Concept, Wealth Accumulation Concept, and Wealth Distribution Concept. The findings from this study were that the four fisherman informants have more assets than debt. In addition, the four fisherman informants have prepared for bad possibilities that will occur in the future. Thus, family financial planning has an important role that can help someone realize prosperity. This was evidenced by the ability to accumulate where the amount of assets owned is greater than debt so that that person has financial freedom. Keywords: Islamic Family Financial Planning, Fishermen, Sidoarjo Regency. REFERENCES Abdullah, A., & Junaina, M. (2013). Ethical values in Islamic planning. Jurnal Pengurusan, 38 (133 – 140). Adiba, E. M., & Shofawati, A. (2017). The role of middlemen and fisherman welfare in maqashid shariah. Journal of Islamic Economics Science, 1(1), 1-15. Agustianto, & Lutfi. (2010). Fiqih perencanaan keuangan syariah. Jakarta: Muda Mapan Publishing. Alkautsar, Z., & Hapsari. M. I. (2014). Implementasi pemahaman konsumsi Islam pada perilaku konsumen muslim. Jurnal Ekonomi Syariah Teori dan Terapan, 1(10), 736-754. https://doi.org/10.20473/vol1iss201410pp736-754 Amanda, F., Possumah, B. T., & Firdaus, A. (2018). Consumerism in personal finance: An Islamic wealth management approach. Al- Iqtishad: Journal of Islamic Economics, 325-340. DOI:10.15408/aiq.vl0i2.5518 Aulia. (2009). Perencanaan keuangan keluarga menciptakan surplus anggaran dalam keuangan keluarga anda. Yogyakarta: Cakrawala. Aulia, N., Yuliati, L, N., & Muflikhati, I. (2019). Kesejahteraan keuangan keluarga usia pension: Literasi keuangan, perencanaan keuangan hari tua, dan kepemilikan aset. Jurnal Ilmu Keluarga dan Konsumen, 12(1), 38-51. https://doi.org/10.24156/jikk.2019.12.1.38 Baidhowi, B., & Zaki, I. (2014). Implementasi konsumsi Islami pada pengajar pondok pesantren (Studi kasus pada pengajar pondok pesantren al aqobah kecamatan diwek kabupaten Jombang). Jurnal Ekonomi Syariah Teori dan Terapan, 1(9), 610-621. https://doi.org/10.20473/vol1iss20149pp610-621 Basah, S., & Tahir, P. R. (2019). Towards acceptance of Islamic wealth management. Journal of Islamic, Social, Economics and Development. DOI: 10.1108/JCM-01-2018-2514] BAZNAS. (2014). Syarat dan tata cara perhitungan zakat mal dan zakat fitrah serta pendayagunaan zakat untuk usaha produktif. Jakarta: BAZNAS. BPS. (2019). Jumlah produksi budidaya ikan menurut kabupaten/kota (ton). Jawa Timur: Badan Pusat Statistik. Finira, D. C., & Yuliati, L. (2013). Perencanaan keuangan keluarga dalam pembelian asuransi jiwa. Jurnal Ilmu Keluarga Dan Konsumen Bogor, 6(3), 180-189. http://dx.doi.org/10.24156/jikk.2013.6.3.180 IBFIM. (2016). Islamic financial planning and wealth management. Kuala Lumpur: IBFIM. Joko, A. (2012). Pola konsumsi, investasi dan proteksi sebagai indikator perencanaan keuangan keluarga (Studi pada masyarakat kabupaten Sidoarjo). Jurnal Media Mahardika, 10(2), 44-66. Lahsasna, A. (2017). Islamic financial planning for households. Wealth Purification, Elgar Online Chapter 15. DOI:10.4337/9781786439390.00024 Mumtahiyah. (2015). Implementasi profesi nelayan muslim dalam mewujudkan kesejahteraan perspektif maqashid syariah (studi kasus kabupaten jembrana bali). Tesis tidak dipublikasikan. Universitas Airlangga. Nurizal, I., & Antonio, M. S. (2012). The Islamic wealth management: An analysis from ibn sina’s perspective. Journal of Islamic Thought and Civilization, 2(1), 19-36. https://doi.org/10.32350/jitc.21 Peter, G. (2014). The role of parents in educating finance at children (library studies). ITI –NGO. Rahmawati. (2010). Tingkat kesadaran masyarakat dalam perencanaan keuangan keluarga perpsektif ekonomi islam (studi pada masyarakat kelurahan cempaka putih ciputan). Skripsi tidak dipublikasikan. UIN Syarif Hidayatullah. Rodhiyah. (2012). Manajemen keuangan keluarga guna menuju keluarga sejahtera. Forum, 40(1), 28-33. Shafii, Z., Zariah, M. Y., & Shahizan, M. (2013). Islamic financial planning and wealth management. Kuala Lumpur: IBFIM. Solomon, M. R. (2013). Consumer behavior: buying, having, and being (tenth edition). Essex: Pearson Education Limited. Tamini, L., & Mukhlisin, M. (2013). Sakinah finance. Solo: Tirta Medina. Yin, R. (2016). Qualitative research from start to finish. New York: The Guilford Press. Yusoff, Z. M., Adawiah, E. R., & Zakariyah, H. (2021). Islamic financial planning: Towards sustaining the financial wellbeing of muslim families in Malaysia post covid-19. Turkish Journal of Islamic Economics, 8(Special Issue), 355-376. http://dx.doi.org/10.26414/A2380 Zulkifli, C. M., & Saripuddin, C. O. A. S. S. (2015). Concept of business ethics in Islam: Approach to the entrepreneur. Journal of Asian Business Strategy, 5(1), 13-18. https://doi.org/10.18488/journal.1006/2015.5.1/1006.1.13.18
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Berkowitz, Scott D., Charles W. Francis, Jennifer McElhattan, and Clifford W. Colwell. "Bleeding Indicators and Wound Complications with Ximelagatran and Warfarin after TKR: Findings from 3 Clinical Trials." Blood 104, no. 11 (November 16, 2004): 1771. http://dx.doi.org/10.1182/blood.v104.11.1771.1771.
Abstract:
Abstract Introduction: Prophylaxis of venous thromboembolism (VTE) in patients undergoing total knee replacement (TKR) most often entails anticoagulation, yet minimization of excessive postoperative bleeding and wound complications is critical to attain an excellent functional result. Ximelagatran (Exanta®, AstraZeneca), the first oral alternative to warfarin, has a rapid onset of action and requires no coagulation monitoring or dose adjustment. Three randomized, double-blind trials of VTE prophylaxis after TKR comparing ximelagatran 24 and 36 mg BID with well-controlled warfarin (target INR 2.5) were completed: Study 236 (n=680), EXULT A (n=2301), and EXULT B (n=2303). When administered for 7–12 days, ximelagatran 36 mg BID was superior to well-controlled warfarin, while 24 mg yielded numerically better but not statistically superior efficacy over warfarin. Adjudicated bleeding rates did not differ significantly. Objective: To assess the postoperative bleeding complications and overall surgical wound appearance during anticoagulation after TKR. Methods: Two comparison pools were created: 36-mg pool (ximelagatran 36 mg and corresponding warfarin groups from EXULT A and B) and 24-mg pool (ximelagatran 24 mg and corresponding warfarin groups from Study 236 and EXULT A). Bleeding indicators, i.e., postoperative wound drainage, bleeding index, and transfusion requirements, were compared. A prespecified subjective assessment of the surgical wound was performed on postoperative Day 3, end of treatment (Day 7–12), and at follow-up (4–6 weeks). If wound appearance was rated “worse than expected” at any time point, wound characteristics of swelling, drainage, erythema, and bleeding were assessed. Intra-articular bleeding, unusual bruising or hematoma, and bleeding requiring an intervention were also recorded. Results: 36-mg Pool (n=3810) 24-mg Pool (n=2178) Bleeding Indicators Ximelagatran Warfarin Ximelagatran Warfarin Post-op wound drainage, mean in mL (95% CI) 697 (675, 718) 704 (682, 725) 659 (632, 686) 654 (626, 682) Bleeding Index, mean (95% CI) 3.4 (3.3, 3.4) 3.3 (3.2, 3.4) 3.2 (3.1, 3.3) 3.1 (3.0, 3.2) Transfusions Unplanned, % of Pts 8.9 8.1 Not Assessed Not Assessed Total, % of Pts 33.5 33.6 37.6 34.3 Vol. Transfused/Pt, mean (95% CI) 630 mL (602, 659) 606 mL (578, 635) 1.7 U (1.6, 1.8) 1.7 U (1.6, 1.8) Overall wound appearance (worse than expected), % 9.2 8.7 8.9 8.2 Wound characteristics (worse than expected) Swelling, % 5.1 4.5 5.7 4.6 Drainage, % 3.6 2.4 2.7 1.8 Erythema, % 3.9 3.7 2.8 3.5 Bleeding, % 1.7 1.2 Not Assessed Not Assessed In the 36- and 24-mg pools the wound was assessed as “expected” or “better than expected” for ≥90% of the patients in the ximelagatran and warfarin groups. For the small number of patients with “worse than expected” wounds, the differences between the ximelagatran and warfarin groups were not statistically significant. Bleeding complications of the surgical wound, including intra-articular bleeding (<3.5%), unusual bruising or hematoma (<5.0%), and bleeding requiring an intervention (<0.9%), were few and comparable between treatment groups. Conclusions: Analysis of bleeding indicators and complications of the surgical wound revealed no significant differences between treatment groups, supporting the safety of 36 mg for all patients undergoing TKR.
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Nabi, H., R. Ibsen, M. Ibsen, J. Kjellberg, M. L. Hetland, and B. Glintborg. "POS0376 DOES A MANDATORY SWITCH FROM ORIGINATOR ADALIMUMAB TO BIOSIMILAR GP2017 OR SB5 LEAD TO INCREASED HOSPITAL COSTS? A DANBIO STUDY OF >1,300 PATIENTS WITH INFLAMMATORY ARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (May 30, 2023): 441–42. http://dx.doi.org/10.1136/annrheumdis-2023-eular.812.
Abstract:
BackgroundIn 2018, Danish national guidelines dictated a mandatory switch from originator to biosimilar adalimumab based on geographical residence, i.e., GP2017 in Eastern regions and SB5 in Western regions of Denmark[1]. The switch was motivated by cost savings (approx. 34-49%). Concerns were raised if hospitals would encounter additional costs as a result of increased numbers of outpatient visits/contacts (due to patient concerns, education, treatment monitoring).ObjectivesTo investigate if the switch from originator to either of the adalimumab biosimilars led to increased hospital costs, defined as all in- and outpatient contacts.MethodsObservational cohort study with surrogate cluster (i.e. geographical) pseudo-randomization. Patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) or axial spondyloartritis (AxSpA), who performed an adalimumab biosimilar switch were identified in the rheumatology registry, DANBIO. Hospital contacts were identified through linkage to the National Patient Registry. Hospital costs (based on DRG tariffs) were reported 9 months pre- and post-switch. In addition, the difference between pre- and postswitch costs was estimated by a generalized estimation equations (GEE) model. Medication costs of adalimumab originator and biosimilars were not available, and thus not included in the model.Results1,318 patients were included (51% male, mean disease duration 16 years) and switched to either GP2017 (n=621) or SB5 (n=695). Baseline characteristics for both treatment groups stratified by diagnosis are given inTable 1.Monthly hospital costs 9 months pre- and post-switch were largely similar or decreased post-switch (Figure 1). No increase was found in the adjusted analyses (GEE); hospital costs decreased post-switch (by approximately 15%) for GP2017 switchers, especially PsA (estimate 0.83; 95% CI 0.75-0.92) and AxSpA patients (estimate 0.85;0.77-0.93), whereas no significant changes were found for SB5 switchers (Table 1).ConclusionIn this study of >1,300 patient with inflammatory arthritis, we found no sign of increased healthcare hospital costs 9 months following a nationwide mandatory adalimumab originator to biosimilar switch. Our findings were strengthened by similar results regardless of whether patients switched to GP2017 or SB5.Reference[1]Nabi H, Georgiadis S, Loft AG, et al. Ann Rheum Dis, doi:10.1136/annrheumdis-2021-219951Figure 1.Hospital costs stratified by biosimilar drug. Black dotted line indicates time of switch. y-axis: Mean cost per patient per monthTable 1.Baseline characteristics of patients who switched from originator adalimumab to biosimilar GP2017 or SB5, stratified by diagnosisGP2017 (n=621)SB5 (n=695)PSARAAxSpAPsARAAxSpANumber of patients (N)146213262173253269Age, years (mean, SD)54 (11)62 (11)48 (12)55 (11)63 (10)49 (11)Female, n (%)80 (55)158 (74)82 (31)58 (34)181 (72)89 (3)Disease duration, years (mean, SD)14 (7)18 (9)14 (10)15 (8)19 (10)14 (8)Duration of originator adalimumab treatment before switch (n,%) <6 years43 (29)59 (28)72 (27)36 (21)34 (13)68 (25) ≥6 years103 (71)154 (72)190 (73)137 (79)219 (87)201 (75)Stopped biosimilar treatment within 180 days (n, %)10 (7)8 (4)15 (6)6 (4)18 (7)16 (6)GLM regression estimates for costs after versus before switching, stratified by drug and diagnosis*GP2017SB5PsARAAxSpAPsARAAxSpATotal hospital costs0.83 (0.75-0.92)§0.99 (0.86-1.14)0.85 (0.77-0.93)§1.03 (0.95-1.13)1.00 (0.93-1.08)1.01 (0.91-1.12)*Adjusted for gender, age, duration of treatment with originator drug (6+ years=1), stopped the medication within 6 months (yes-no) and comorbidity (number of WHO 21 chapters excluding WHO 13 ICD-10 M). After=1 included as a dummy variable, and the estimates for this shows whether there were changes over time.§p-values <0.05.AcknowledgementsWe thank all the Danish departments of rheumatology, which report to the DANBIO registry. Also the work of IT consultant Niels Steen Krogh, Zitelab Aps, who extracted data from DANBIO is acknowledged.Disclosure of InterestsHafsah Nabi Grant/research support from: Research grant from AbbVie, who had no influence on the data collection, statistical analyses or decision to submit.Other research grants: Sandoz, Rikke Ibsen: None declared, Michael Ibsen: None declared, Jakob Kjellberg: None declared, Merete L. Hetland Speakers bureau: Biogen, Celtrion, Janssen Biologics B.V, MSD, Pfizer, Samsung Bioepis, Consultant of: Biogen, Celtrion, Janssen Biologics B.V, MSD, Pfizer, Samsung Bioepis, Grant/research support from: AbbVie, Biogen, BMS, Eli Lilly Denmark A/S, Lundbeck Fonden, Novartis, Pfizer, Roche, Sandoz., Bente Glintborg Grant/research support from: BMS, Pfizer, Sandoz.
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Murphy, K. T., W. A. Macdonald, M. J. McKenna, and T. Clausen. "Ionic mechanisms of excitation-induced regulation of Na+-K+-ATPase mRNA expression in isolated rat EDL muscle." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 290, no. 5 (May 2006): R1397—R1406. http://dx.doi.org/10.1152/ajpregu.00707.2005.
Abstract:
This study investigated the effects of electrical stimulation on Na+-K+-ATPase isoform mRNA, with the aim to identify factors modulating Na+-K+-ATPase mRNA in isolated rat extensor digitorum longus (EDL) muscle. Interventions designed to mimic exercise-induced increases in intracellular Na+ and Ca2+ contents and membrane depolarization were examined. Muscles were mounted on force transducers and stimulated with 60-Hz 10-s pulse trains producing tetanic contractions three times at 10-min intervals. Ouabain (1.0 mM, 120 min), veratridine (0.1 mM, 30 min), and monensin (0.1 mM, 30 min) were used to increase intracellular Na+ content. High extracellular K+ (13 mM, 60 min) and the Ca2+ ionophore A-23187 (0.02 mM, 30 min) were used to induce membrane depolarization and elevated intracellular Ca2+ content, respectively. Muscles were analyzed for Na+-K+-ATPase α1–α3 and β1–β3 mRNA (real-time RT-PCR). Electrical stimulation had no immediate effect on Na+-K+-ATPase mRNA; however at 3 h after stimulation, it increased α1, α2, and α3 mRNA by 223, 621, and 892%, respectively ( P = 0.010), without changing β mRNA. Ouabain, veratridine, and monensin increased intracellular Na+ content by 769, 724, and 598%, respectively ( P = 0.001) but did not increase mRNA of any isoform. High intracellular K+ concentration elevated α1 mRNA by 160% ( P = 0.021), whereas A-23187 elevated α3 mRNA by 123% ( P = 0.035) but reduced β1 mRNA by 76% ( P = 0.001). In conclusion, electrical stimulation induced subunit-specific increases in Na+-K+-ATPase mRNA in isolated rat EDL muscle. Furthermore, Na+-K+-ATPase mRNA appears to be regulated by different stimuli, including cellular changes associated with membrane depolarization and increased intracellular Ca2+ content but not increased intracellular Na+ content.
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Stewart, Nancy H., Anya Koza, Serena Dhaon, Christiana Shoushtari, Maylyn Martinez, and Vineet M. Arora. "Sleep Disturbances in Frontline Health Care Workers During the COVID-19 Pandemic: Social Media Survey Study." Journal of Medical Internet Research 23, no. 5 (May 19, 2021): e27331. http://dx.doi.org/10.2196/27331.
Abstract:
Background During the COVID-19 pandemic, health care workers are sharing their challenges, including sleep disturbances, on social media; however, no study has evaluated sleep in predominantly US frontline health care workers during the COVID-19 pandemic. Objective The aim of this study was to assess sleep among a sample of predominantly US frontline health care workers during the COVID-19 pandemic using validated measures through a survey distributed on social media. Methods A self-selection survey was distributed on Facebook, Twitter, and Instagram for 16 days (August 31 to September 15, 2020), targeting health care workers who were clinically active during the COVID-19 pandemic. Study participants completed the Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI), and they reported their demographic and career information. Poor sleep quality was defined as a PSQI score ≥5. Moderate-to-severe insomnia was defined as an ISI score >14. The Mini-Z Burnout Survey was used to measure burnout. Multivariate logistic regression tested associations between demographics, career characteristics, and sleep outcomes. Results A total of 963 surveys were completed. Participants were predominantly White (894/963, 92.8%), female (707/963, 73.4%), aged 30-49 years (692/963, 71.9%), and physicians (620/963, 64.4%). Mean sleep duration was 6.1 hours (SD 1.2). Nearly 96% (920/963, 95.5%) of participants reported poor sleep (PSQI). One-third (288/963, 30%) reported moderate or severe insomnia. Many participants (554/910, 60.9%) experienced sleep disruptions due to device use or had nightmares at least once per week (420/929, 45.2%). Over 50% (525/932, 56.3%) reported burnout. In multivariable logistic regressions, nonphysician (odds ratio [OR] 2.4, 95% CI 1.7-3.4), caring for patients with COVID-19 (OR 1.8, 95% CI 1.2-2.8), Hispanic ethnicity (OR 2.2, 95% CI 1.4-3.5), female sex (OR 1.6, 95% CI 1.1-2.4), and having a sleep disorder (OR 4.3, 95% CI 2.7-6.9) were associated with increased odds of insomnia. In open-ended comments (n=310), poor sleep was mapped to four categories: children and family, work demands, personal health, and pandemic-related sleep disturbances. Conclusions During the COVID-19 pandemic, nearly all the frontline health care workers surveyed on social media reported poor sleep, over one-third reported insomnia, and over half reported burnout. Many also reported sleep disruptions due to device use and nightmares. Sleep interventions for frontline health care workers are urgently needed.
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Hijiya, Nobuko, John C. Panetta, Yinmei Zhou, Emily P. Kyzer, Scott C. Howard, Sima Jeha, Bassem I. Razzouk, et al. "Body mass index does not influence pharmacokinetics or outcome of treatment in children with acute lymphoblastic leukemia." Blood 108, no. 13 (December 15, 2006): 3997–4002. http://dx.doi.org/10.1182/blood-2006-05-024414.
Abstract:
Abstract There is conflicting information about the influence of body mass index (BMI) on the pharmacokinetics, toxicity, and outcome of chemotherapy. We compared pharmacokinetics, outcome, and toxicity data across 4 BMI groups (underweight, BMI ≤ 10th percentile; normal; at risk of overweight, BMI ≥ 85th and < 95th percentile; overweight, BMI ≥ 95th percentile) in 621 children with acute lymphoblastic leukemia (ALL) treated on 4 consecutive St Jude Total Therapy studies. Chemotherapy doses were not adjusted to ideal BMI. Estimates of overall survival (86.1% ± 3.4%, 86.0% ± 1.7%, 85.9% ± 4.3%, and 78.2% ± 5.5%, respectively; P = .533), event-free survival (76.2% ± 4.2%, 78.7% ± 2.1%, 73.4% ± 5.5%, and 72.7% ± 5.9%, respectively; P = .722), and cumulative incidence of relapse (16.0% ± 3.7%, 14.4% ± 1.8%, 20.6% ± 5.1%, and 16.7% ± 5.1%, respectively; P = .862) did not differ across the 4 groups. In addition, the intracellular levels of thioguanine nucleotides and methotrexate polyglutamates did not differ between the 4 BMI groups (P = .73 and P = .74, respectively). The 4 groups also did not differ in the overall incidence of grade 3 or 4 toxicity during the induction or postinduction periods. Further, the systemic clearance of methotrexate, teniposide, etoposide, and cytarabine did not differ with BMI (P > .3). We conclude that BMI does not affect the outcome or toxicity of chemotherapy in this patient population with ALL.
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Méndez-Flores, Jhonatan J., Ruth E. Marroquín-Cosar, and Antonio Bernabé-Ortiz. "Multimorbidity and Sleep Patterns among Adults in a Peruvian Semi-Urban Area." Sleep Science 16, no. 01 (March 2023): 051–58. http://dx.doi.org/10.1055/s-0043-1767755.
Abstract:
Abstract Objective To assess if the duration and quality of sleep vary due to the presence of multimorbidity. Materials and Methods We performed a secondary analysis using data from a population-based study involving adult subjects aged between 30 and 69 years residing in a semi-urban area of Tumbes, Peru. The duration (normal, short or prolonged) and quality (good or poor) of sleep were our outcome variables, whereas the exposure was multimorbidity (two or more chronic conditions). Crude and adjusted Poisson regression models were built to assess the association of interest, and prevalence ratios (PRs) and 95% confidence intervals (95%CIs) were reported. Results We analyzed data from 1,607 subjects with a mean age of 48.2 (standard deviation [SD]: ± 10.6) years, 809 (50.3%) of whom were women. Multimorbidity was present in 634 (39.5%; 95%CI: 37.1–41.9%) subjects, and 193 (12.1%; 95%CI: 10.5–13.7%) were short sleepers, 131 (8.2%; 95%CI: 6.9–9.6%) were long sleepers, and 312 (19.5%; 95%CI: 17.5–21.5%) had poor sleep quality. In the multivariable model, multimorbidity was associated with prolonged sleep duration (PR = 1.45; 95%CI: 1.03–2.04) and poor sleep quality (PR = 2.04; 95%CI: 1.65–2.52). Conclusions Multimorbidity was associated with prolonged, but not short, sleep duration, as well as with poor sleep quality. Our results suggest the need of assessing sleep patterns among adults with multimorbidity.
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Wohlfeil, Margo, Cole Neary, Mitchell Klocke, Johnny Mills, Rich Calvert, and David Senchina. "Should high-top or low-top cleats be used when playing baseball." American Journal of Undergraduate Research 16, no. 1 (June 23, 2019): 5–13. http://dx.doi.org/10.33697/ajur.2019.011.
Abstract:
There is a shortage of knowledge about how baseball cleat design may impact athletes. The purpose of this experiment was to determine if the height of the baseball cleat affected performance, perception of the cleat, and ankle range-of-motion. Thirteen subjects participated in the study, and each subject performed three drills (base-running, 5:10:5 "pro agility," and hitting) in both high-top and low-top baseball cleats. Performance time was measured for the first two drills. Perception of comfort, heaviness, shoe climate (heat), stability, and traction were measured for all three drills using 10-cm visual analog scales (VAS). Ankle range-of-motion (dorsiflexion, plantarflexion, eversion, and inversion) was measured using goniometry in both cleats, plus socks-only as baseline control. Shoe height did not significantly affect completion time in either the base-running drill (6.1±0.1 sec. in high-top vs. 6.1±0.1 sec. in low-top) or pro-agility drill (4.8±0.1 sec. in high-top vs. 4.6±0.1 sec. in low-top). There were significant differences in perception of heat (6.4 in high-top vs. 4.6 in low-top; p<.001), stability (6.9 in high-top vs. 5.1 in low-top; p=.001), and heaviness (6.0 in high-top vs. 4.1 in low-top; p<.001), but not in perception of comfort (6.1±2.0 in high-top vs. 6.6±1.5 in low top) or traction (7.3±2.0 in high-top vs. 7.4±1.5 in low-top). There were significant differences between high-top and low-top cleats in plantarflexion (42.5° in high-top vs. 47.5° in low-top; p=.033), eversion (7.9° in high-top vs. 11.3° in low-top; p=.003), and inversion (12.8° in high-top vs. 16.6° in low-top; p=.044), but not dorsiflexion (8.2° in high-top vs. 10.9°). For baseball players concerned about excessive ankle movements during play, these results suggest that using a high-top baseball cleat might reduce ankle range-of-motion without impairing performance or feeling burdensome. KEYWORDS: Baseball; Cleats; High-Top; Low-Top; Perception; Performance; Range-of-Motion; Shoes
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Elkholly, Doaa A., Dan O’Neill, Andrea K. Wright, Kennedy Mwacalimba, Laura S. Nolan, Amy Pavlock, Ludovic Pelligand, David Church, and David C. Brodbelt. "Systemic glucocorticoid usage in dogs under primary veterinary care in the UK: prevalence and risk factors." Veterinary Record 185, no. 4 (May 10, 2019): 108. http://dx.doi.org/10.1136/vr.105220.
Abstract:
Glucocorticoids are widely used in primary care veterinary practices. The study aimed to quantify the usage of systemic glucocorticoids (SGC) in dogs in the UK using primary care treatment records recorded during 2013 in the VetCompass Programme. From a study population of 455 557 dogs, 28 472 dogs (6.2 per cent, 95 per cent CI 6.2 to 6.3) received a total of 50 971 SGC therapy events in 2013. Prednisolone represented the most frequently used oral preparation (27 362 events, 90.0 per cent of oral events). Dexamethasone sodium phosphate was the most commonly used injectable agent (12 796 events, 62.7 per cent of injectable events). The most common breed treated was Staffordshire Bull Terriers (2236/28 472 dogs, 7.9 per cent, 95 per cent CI 7.5 to 8.2) and within-breed prevalence of SGC usage was 2236/32 635, 6.9 per cent, 95 per cent CI 6.6 to 7.1. The most commonly treated age group was dogs older than eight years (8931/28472, 31.4 per cent) and the most commonly treated bodyweight group was 10.01–20.0 kg (7918/28 472, 27.8 per cent). Dexamethasone and prednisolone were the most commonly prescribed SGC. Short-acting and intermediate-acting injectable SGC were more commonly used compared with long-acting injectable SGC. Older and medium size dogs were most likely to receive SGC and certain breeds appeared predisposed. These data can provide a useful benchmark for glucocorticoid usage and highlight the benefits from ‘Big Data’ analyses.
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Keenan, Bridget, Elizabeth McCarthy, Arielle Ilano, Hai Yang, Li Zhang, Kathryn Allaire, Zenghua Fan, et al. "676 Altered circulating myeloid states associated with anti-PD-1 resistance induce T cell paralysis in human biliary cancer." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (November 2021): A704. http://dx.doi.org/10.1136/jitc-2021-sitc2021.676.
Abstract:
BackgroundAdvanced biliary cancers (ABC) have a poor prognosis and low rates of response to immune checkpoint inhibition (CPI), with overall response rates ranging from 3–13%.1–3 Although suppressive myeloid cells have been proposed as a mechanism of resistance to immunotherapy in general, their relationship to response to CPI is unknown.MethodsWe used multiplexed simultaneous single cell RNA sequencing and cell surface proteomics (CITE-seq) to profile circulating immune cells in ABC patients receiving anti-PD-1 at longitudinal timepoints pre-immunotherapy and on treatment, as well as from healthy donors. We also performed single cell RNA sequencing on resected biliary tumors.ResultsWe identified a novel population of circulating cancer-enriched myeloid cells (CEM) characterized by chemokines and extracellular matrix digestion-related gene expression, which were present pre-treatment. Anti-PD-1 treatment drove the CEMs into two diverging states that were associated with response or resistance to treatment. CEM induced in non-responders constituted over 40% of the circulating myeloid cells and expressed immunosuppressive programs, including the upregulation of suppressive cytokines and chemokines. The frequency of these myeloid cells were correlated with the abundance of SOCS3-expressing CD4+ T cells. These SOCS3+CD4+ T cells also colocalized with tumor-infiltrating myeloid cells that share CEM gene expression signatures in the biliary cancer microenvironment. Moreover, CEM can directly induce SOCS3-expressing T cells, which despite their naïve phenotype are functionally unresponsive. Finally, expression signatures of CEM and of SOCS3+CD4+ T cells are associated with worse survival in a larger cohort of ABC patients.ConclusionsThese results demonstrate the capacity of CEM to induce T cell paralysis as an alternate mode of tumor-mediated immunosuppression. A deeper understanding of immune cell biology in ABC provides insights for developing novel therapeutics that can overcome immunotherapy resistance in biliary cancer as well as other tumor types.Trial RegistrationNCT02703714ReferencesUeno M, et al. Nivolumab alone or in combination with cisplatin plus gemcitabine in Japanese patients with unresectable or recurrent biliary tract cancer: a non-randomised, multicentre, open-label, phase 1 study. Lancet Gastroenterol Hepatol 2019;4:611–621.Piha-Paul SA, et al. Efficacy and safety of pembrolizumab for the treatment of advanced biliary cancer: results from the KEYNOTE-158 and KEYNOTE-028 studies. Int J Cancer 2020.Kim RD, et al. A Phase 2 Multi-institutional study of nivolumab for patients with advanced refractory biliary tract cancer. JAMA Oncol 2020;6:888–894.Ethics ApprovalInformed consent was obtained from all patients for participation in the listed trial and for use of blood and tumor samples in research studies.
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Gacovski, Z., and G. Cilev. "Biological and genetical characteristics of hybrid maize Kneza 683A." Biotehnologija u stocarstvu 27, no. 4 (2011): 1513–22. http://dx.doi.org/10.2298/bah1104513g.
Abstract:
The basic biological and economic properties of the hybrid maize Kneza 683A, created in Maize Research Institute - Kneza, R. Bulgaria by the method of interline hybridization are briefly described. The hybrid is acknowledged during year 1994 after two years variety-testing in SVTC (State Variety-Testing Commission) with standards American hybrids of maize H 708 and Ivana. During the period of testing, in year 1992 and 1993, in condition without irrigation, the average enlargement of yield on hybrid maize Kneza 683A (8 140 kg/ha), in comparison with hybrid maize H 708 (7 210 kg/ha) was 11, 42% and with hybrid maize Ivana (7610 kg/ha) was 6,51%. In conditions with irrigation, the average enlargement of yield on hybrid maize Kneza 683A (10 610 kg/ha), compared to first standard H 708 (9 890 kg/ha) was 6,78%, and compared to second standard Ivana (10 570 kg/ha) was 0,37%.The hybrid maize Kneza 683A, was examined in year 1994 and 1995 in R. Macedonia in conditions with irrigation and in R.Bulgaria, without irrigation. In comparison with standard american hybrid of maize H 708 (11 233 kg/ha), in our country the average enlargement of yield on the hybrid maize Kneza 683A (11 556 kg/ha) was 2,79%, and in R. Bulgaria was 8,04%. In the examination in year 2006 in R. Macedonia in conditions with irrigation, the average enlargement of yield on the hybrid maize Kneza 683A (11 600 kg/ha) in comparison with standard Kneza 630 (8 830 kg/ha) was 8,04% and hybrid Kneza 621 (11 200 kg/ha) was 3,44%. After examination from SVTC, in year 2007, the University "Goce Delcev" Stip, Institute for Southern Crops in Strumica in our country have registered the hybrid on the sort list. In 2008 was organised seed production on area of 1 ha and there was yield of 2000 kg/ha, which means that although the late sowing there was good yield of seed. In field conditions the hybrid is practically resistant to the economically important disease by the maize. The seed production of the hybrid maize Kneza 683A carry out with simultaneously sowing of the parental components using cytoplasmic male sterility (CMS) and fully restoration of fertility in hybrid generation. The hybrid maize Kneza 683A successfully shift the late Bulgarian and foreign hybrids (group 600 by FAO), since is more drought-resistant and considerably exceeds them by grain yield and silage mass from a unit of area.
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Jacob, Saya, Hongmei Yu, Denise M. Wolf, Aheli Chattopadhyay, Susie Brain, Carol Simmons, Kathryn Jean Ruddy, et al. "Use of PROMIS to capture patient reported outcomes over time for patients on I-SPY2." Journal of Clinical Oncology 41, no. 16_suppl (June 1, 2023): 611. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.611.
Abstract:
611 Background: Patient reported outcomes (PROs) capture direct feedback from patients in clinical trials. The NIH Patient-Reported Outcomes Measurement Information System (PROMIS) is an open source and validated PRO platform. Data on PROMIS score trajectories over time for breast cancer patients undergoing neoadjuvant chemotherapy (NAC) are limited. Methods: We administered paper surveys to patients enrolled on the I-SPY2 trial, a multicenter, randomized phase 2 trial comparing novel agents to standard NAC in high-risk breast cancer. PRO domains included PROMIS Physical Function, Anxiety, Depression, Applied Cognition and Fatigue. Surveys were administered at baseline (post-consent), C1D1, inter-regimen (~12 wks into NAC), pre-surgery and at 1, 6, 12, and 24 months post-surgery. Responses were scored using the HealthMeasures Scoring Service to generate a standardized T score, with a score of 50 representing the general US population mean. Higher Anxiety, Depression and Fatigue scores represent worse symptoms; higher Physical Function and Applied Cognition scores represent better symptoms. We calculated average scores by time-point and compared changes from baseline to various grouped time points using a paired t-test. Results: From 1/2012 to 7/2020, 1631 patients enrolled in I-SPY 2 with 959 completing the baseline survey. 62% had at least two “on-treatment” surveys, and 52% had at least one follow-up time-point. Average baseline PROMIS scores for Physical Function, Anxiety, Depression, Applied Cognition and Fatigue were 46.7, 55.1, 47.2, 53.3 and 46.0 respectively. Between baseline and the latest on-treatment time point we observed improvement in Anxiety (-5.2) and worsening in Physical Function, Applied Cognition and Fatigue (-5.4, -6.9 and +8.2 respectively). Between baseline and the latest post-surgery time point, we saw improved Anxiety (-5.9) and worsened Physical Function, Applied Cognition and Fatigue (-5.9, -3.6 and +4.3). Depression changed minimally. Conclusions: Using PROMIS, patients on I-SPY2 experienced worse Physical Function, Applied Cognition and Fatigue but improved Anxiety during and after treatment compared to baseline. While changes in Applied Cognition and Fatigue recovered partially after treatment, Physical Function scores did not, suggesting potential for longer term impact on quality of life. Clinical trial information: NCT01042379 . [Table: see text]
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Simonneau, Gerald. "Nadroparin 0.3 mL Versus Enoxaparin 40 mg in the Prevention of Venous Thromboembolism in Abdominal Surgery for Colorectal Cancer: A Randomized Double-Blind Comparative Study." Blood 106, no. 11 (November 16, 2005): 552. http://dx.doi.org/10.1182/blood.v106.11.552.552.
Abstract:
Abstract Background: The relative benefit-to-risk ratio of various LMWH in the setting of colorectal cancer surgery has never been directly compared. Objective: We performed a multicenter, randomized, double-blind study to compare the efficacy and safety of enoxaparin 40 mg (4000 anti-Xa IU) and nadroparin 0.3 mL (2850 anti-Xa IU) in the prevention of venous thromboembolism (VTE) after colorectal cancer surgery. Methods: Patients undergoing elective colorectal adenocarcinoma resection under general anesthesia were recruited. They were randomized to receive once daily either nadroparin 0.3 mL or enoxaparin 40 mg subcutaneously for 9±2 days, starting 2 to 4 hours preoperatively. The primary efficacy outcome was the composite of deep-vein thrombosis (DVT) detected by bilateral venography or documented symptomatic DVT or pulmonary embolism (PE) up to Day 12. The main safety outcomes were major bleeding and all-cause death. A blinded independent committee adjudicated all outcomes. Results: A total of 1288 patients (median age: 69, range: 26–97 years; men: 61.4%) were randomized either to nadroparin (n=653) or to enoxaparin (n=635). Efficacy was evaluable in 950 (73.8%) patients who underwent contrast venography or had a symptomatic thromboembolic event. The rate of VTE at Day 12 was 15.9% for nadroparin and 12.6% for enoxaparin (relative risk reduction 21.3% [95% CI: −7.75; 42.5]). This difference was not statistically significant (p=0.13, Chi-squared test). In contrast, there were more symptomatic VTE, including symptomatic PE, in the enoxaparin group than in the nadroparin group (Table). Furthermore, the rate of major bleeding was significantly lower in nadroparin-treated patients than in enoxaparin-treated patients (Table). By Day 12, there were three (0.5%) deaths related to VTE or major bleeding in enoxaparin patients compared with none in nadroparin patients. By Day 60, 23 (3.5%) patients receiving nadroparin and 23 (3.5%) patients receiving enoxaparin had died. Conclusion: Enoxaparin 40 mg was not more effective than nadroparin 0.3 mL in the prevention of total VTE in patients undergoing colorectal cancer surgery. The non-significant difference between the two groups was mainly due to a lower rate of asymptomatic distal DVT in the enoxaparin group than in the nadroparin group. However, nadroparin was more effective than enoxaparin for reducing symptomatic VTE, including PE, and was associated with significantly less major bleeding. Efficacy and safety results at Day 12 Nadroparin 0.3 mL, n/N (%) Enoxaparin 40 mg, n/N (%) p *Chi-squared test Total VTE 74/464 (15.9) 61/486 (12.7) 0.13* Asymptomatic proximal DVT 15/503 (3.0) 14/515 (2.7) 0.81 Asymptomatic distal DVT 58/503 (11.5) 42/515 (8.2) 0.07 Symptomatic VTE 1/643 (0.2) 9/628 (1.4) 0.01 Symptomatic proximal DVT 1/643 (0.2) 4/628 (0.6) 0.22 Symptomatic PE 0/643 (0.0) 5/628 (0.8) 0.03 Major bleeding 47/643 (7.3) 72/628 (11.5) 0.01 All-cause death 2/643 (0.3) 8/628 (1.3) 0.06
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Demetrio, D., A. Magalhaes, M. Oliveira, R. Santos, and R. Chebel. "11 Invivo-derived embryo pregnancy rates at Maddox Dairy from 2008 to 2018." Reproduction, Fertility and Development 32, no. 2 (2020): 130. http://dx.doi.org/10.1071/rdv32n2ab11.
Abstract:
Maddox Dairy, located in Riverdale, CA, USA, is a Holstein herd that milks 3500 cows with a 305-day mature-equivalent milk production of 12 800 kg, and they have been producing high genetic animals by embryo transfer (ET) since the early 1980s. Invivo-derived embryos from Holstein donors were transferred fresh (grade 1 or 2) or frozen (grade 1), at morula (4), early blastocyst (5), or blastocyst (6) stage, to virgin heifers (VH, natural oestrus, 13-15 months old) or lactating cows (LC, Presynch-Ovsynch, 86 days in milk, first or second lactation) 6 to 9 days after oestrus. Pregnancy diagnosis was done by transrectal ultrasonography at 32-46 days in VH and by the IDEXX PAG test at 30 days in LC. June, July, August, September, and October were called critical months (first service AI conception rate drops below 44%) and compared with the other months. The data from 32 503 ETs between January 2008 and December 2018 are summarised on Table 1. Pregnancy rates (PR) are lower for LC recipients than for VH. Embryo transfers performed 7 or 8 days after oestrus had higher PR in both types of recipients and embryos, but Day 6 and 9 oestrus are also used with fair results. The season does not seem to affect PR. There is not enough difference in the combination of stage and days from oestrus for invivo-derived embryos. These numbers do not belong to a planned experiment. Several management changes during the years were made, which make it very difficult to apply statistical methods to analyse the data correctly. They are used as a tool to make decisions in an attempt to improve future results. Table 1.Pregnancy rate (PR) of virgin heifers (top) and lactating cows (bottom)-fresh (SH) and frozen (OZ) invivo-derived embryo transfer1 Heat-months SH-ST4 SH-ST5 SH-ST6 SH-All OZ-ST4 OZ-ST5 OZ-ST6 OZ-All PR% n PR% n PR% n PR% n PR% n PR% n PR% n PR% n Heifers 6 d-CM 62 934 66 243 68 69 63 1246 56 473 58 219 62 42 57 734 6 d-OM 62 1623 67 489 69 211 64 2323 56 600 55 296 48 137 55 1033 6 d-T 62 2557 67 732 69 280 63 3569 56 1073 57 515 51 179 56 1767 7 d-CM 64 1506 68 495 67 221 65 2222 60 822 62 340 63 156 61 1318 7 d-OM 66 2723 68 1021 69 510 67 4254 57 1120 59 581 57 231 58 1932 7 d-T 66 4229 68 1516 69 731 67 6476 58 1942 60 921 60 387 59 3250 8 d-CM 65 1348 64 518 67 322 65 2188 59 595 64 258 63 108 61 961 8 d-OM 66 2166 68 886 70 510 67 3562 61 770 60 364 51 130 60 1264 8 d-T 66 3514 67 1404 69 832 66 5750 60 1365 62 622 56 238 60 2225 9 d-CM 60 109 56 43 70 20 60 172 60 5 33 6 50 4 47 15 9 d-OM 58 129 63 57 60 40 60 226 63 16 50 18 75 4 58 38 9 d-T 59 238 60 100 63 60 60 398 62 21 46 24 63 8 55 53 All-CM 64 3897 66 1299 67 632 65 5828 58 1895 61 823 63 310 60 3028 All-OM 65 6641 67 2453 69 1271 66 10 365 58 2506 58 1259 53 502 58 4267 All-T 65 10 538 67 3752 69 1903 66 16 193 58 4401 60 2082 57 812 59 7295 Lactating cows 6 d-CM 54 265 48 86 50 12 53 363 38 141 31 77 50 10 36 228 6 d-OM 49 463 52 203 45 56 50 723 46 101 48 54 59 27 48 182 6 d-T 51 728 51 289 46 68 51 1086 41 242 38 131 57 37 42 410 7 d-CM 54 755 59 274 56 103 55 1137 43 928 48 450 43 192 45 1570 7 d-OM 55 914 66 367 54 109 58 1393 46 1052 45 564 47 353 46 1969 7 d-T 55 1669 63 641 55 212 57 2530 45 1980 46 1014 46 545 45 3539 8 d-CM 63 252 68 82 76 33 65 368 48 219 56 80 42 33 50 332 8 d-OM 61 257 64 161 53 47 61 466 50 191 53 77 56 16 51 284 8 d-T 62 509 65 243 63 80 63 834 49 410 55 157 47 49 50 616 All-CM 56 1272 58 442 60 148 57 1868 44 1288 47 607 43 235 45 2130 All-OM 55 1634 62 731 51 212 56 2582 47 1344 46 695 48 396 47 2435 All-T 55 2906 60 1173 55 360 57 4450 45 2632 47 1302 46 631 46 4565 1ST=stage; CM=critical months (June, July, August, September, and October); OM=other months.
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Bordin, D. S., Yu V. Embutnieks, L. G. Vologzhanina, T. A. Ilchishina, I. N. Voynovan, A. S. Sarsenbaeva, O. V. Zaitsev, et al. "European registry Helicobacter pylori (Hp-EuReg): how has clinical practice changed in Russia from 2013 to 2018 years." Terapevticheskii arkhiv 91, no. 2 (February 15, 2019): 16–24. http://dx.doi.org/10.26442/00403660.2019.02.000156.
Abstract:
The multicenter prospective observational study initiated by the European Helicobacter and Microbiota Study Group (EHMSG) is conducted in 27 countries in Europe. The data from the Russian part of the European registry for the management of Helicobacter pylori infection (European Registry on the management of Helicobacter pylori infection, protocol: “Hp-EuReg”) allows us to analyze the real clinical practice of diagnosis and treatment of H. pylori and compare it with international recommendations. Materials and methods. A comparative analysis of the data entered in the register by the Russian research centers “Hp-EuReg”, in the period from 2013 to 2018, was conducted. Results and discussion. Invasive diagnostic methods prevail for the primary diagnosis of H. pylori [histology - 20.3% (in 2013 year) - 43.9% (in 2018 year), rapid urease test - 31.7% and 47.8% respectively]. The most popular mode of eradication therapy is a 10-day triple therapy (62.8-76.2%), the effectiveness of which does not exceed 79% (per protocol). Invasive tests (histology) are the leading method for control the effectiveness of therapy, however, there is a tendency towards a wider use of non-invasive methods (H. pylori stool antigen - from 17% in 2013 to 29.3% in 2018 and urea breath test from 6.9 to 18.3%, respectively). Serological test to control the effectiveness of eradication is still used from 8.2% (2013) to 6.1% (2018). Eradication therapy was not performed in 28% of patients throughout the entire observation period. Conclusion. In Russia, despite approved domestic and international recommendations, deviations in clinical practice persist, both during eradication therapy and in monitoring the effectiveness of eradication therapy.
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Gray, Rosaire P., Timothy J. Hendra, David L. H. Patterson, and John S. Yudkin. "“Spontaneous” Platelet Aggregation in Whole Blood in Diabetic and Non Diabetic Survivors of Acute Myocardial Infarction." Thrombosis and Haemostasis 70, no. 06 (1993): 0932–36. http://dx.doi.org/10.1055/s-0038-1649702.
Abstract:
SummaryThere is increasing evidence that platelet thrombi play an important role in the pathogenesis of acute myocardial infarction (AMI). We compared “spontaneous” platelet aggregation in whole blood in 17 non-diabetic and 12 diabetic subjects on admission with AML There was no significant difference in the fall in platelet count between the two groups, expressed as platelets remaining (75.2 ± 7.9% vs 77.3 ± 6.9% at 10 min, 66.6 ± 8.9% vs 68.5 ± 6.3% at 20 min, 63.5 ± 8.2% vs 64.9 ± 6.7% at 30 min and 59.4 ± 10.3% vs 61.3 ± 7.6% at 60 min). The rate of “spontaneous” aggregation was increased in subjects with evidence of heart failure on admission compared to those without (59.9 ± 7.9% vs 66.2 ± 6.6% at 30 min [p = 0.05] and 55.4 ± 9.6% vs 63.1 ± 7.7% at 60 min [p = 0.04]). There was no correlation between the fall in platelet count and admission plasma glucose, glycated heaemoglobin or peak aspartate aminotransferase. The subjects studied on admission with AMI had greater rates of “spontaneous” aggregation than 8 subjects studied between 6 and 12 months after acute myocardial infarction (75.9 ± 7.4% vs 85.8 ± 5.4% at 10 min; p = 0.001 and 64.3 ± 7.5% vs 75.0 ± 7.8% at 30 min; p = 0.006) and compared to normal controls (90.7 ± 4.4% at 10 min; p <0.001 and 83.4 ± 6.5 at 30 min; p <0.001). This study provides evidence of increased “spontaneous” platelet aggregation in subjects admitted with acute myocardial infarction but no difference between diabetic and non-diabetic subjects was observed.
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Santos, Marcos Antonio, Delphine Lefeuvre, Gwenael Le Teuff, Damien Bouda, Céline Bourgier, Julien Domont, Frederic Dhermain, Jean-Charles Soria, Eric Deutsch, and Jean-Pierre Pignon. "Evaluation of toxicities of target therapy phase I and II trials on glioblastoma multiforme patients treated by curative radiotherapy: A meta-analysis." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 3063. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.3063.
Abstract:
3063 Background: An important limitation of the combination of target therapies (TT) to radiation (RT) is its potentially high level of toxicity. The objective of this study was to describe and quantify the drug related acute adverse events presented by patients taking part in phase I and/or phase II trials on TT combined to curative RT for the treatment of glioblastoma multiforme (GBM). Methods: A meta-analysis of summary data including all phase I, I/II and II trials published between 2000 and 2011 on newly diagnosed GBM patients treated by TT with RT was performed. Pooled incidence rates (IR) of all and specific toxicities were estimated using a generalized linear mixed model with fixed and random study effects. The pooled median of progression-free (PFS) and overall survivals (OS) were also considered. These results were compared to those obtained by patients receiving standard treatment (ST). Results: Twenty-one trials (8 phases I, 3 phases I/II and 10 phases II), testing 9 different drugs, have been selected, including 915 patients. The median follow-up varied from 1.4 to 34.0 months. The estimated pooled IR of all toxicities was 68.6 [53.5-88.0] per 1000 person-months of follow-up, compared to 20.7 [17.6-24.1] on ST (p<0.001). The pooled IRs of thrombocytopenia, neutropenia or leucopenia, fatigue, gastrointestinal events and treatment-related deaths are 11.2 [7.5-16.9], 9.0 [6.1-13.4], 6.4 [4.1-10.0], 5.5 [2.9-10.2] and 3.2 [1.6-6.4], compared to 4.1 [2.8-5.8], 4.9 [3.5-6.6], 4.6 [3.2-6.4], 0.8 [0.3-1.6] and 0.1 [0.0-0.6], respectively, on ST. Median survival times are 7.7 [6.1-9.8] and 13.8 months [11.9-16.1] on TT studies, and 6.9 [5.8-8.2] and 14.6 [13.2-16.8], on ST, for PFS and OS, respectively, without statistically significant difference (p=0.39 and 0.55). The heterogeneity among specific toxicities and survival endpoints may be partially explained by the study design and/or the intake or not of temozolomide. Conclusions: The use of TT combined to RT represented a significative increase in severe adverse events in patients with GBM compared to ST, whereas no significant difference was observed in survival endpoints. Grants from French Cancer League.
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Sunakawa, Yu, Chaochen Wang, Yongzhe Piao, Long Jin, Yoshinori Tanizawa, Zhihong Cai, and Yoshinori Kagawa. "Real-world evidence of FOLFIRI combined with anti-angiogenesis inhibitors or anti-EGFR antibodies for patients with early recurrence colorectal cancer after adjuvant FOLFOX/CAPOX therapy in Japan: A retrospective observational study using administrative database." Journal of Clinical Oncology 42, no. 3_suppl (January 20, 2024): 110. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.110.
Abstract:
110 Background: Oxaliplatin-containing regimens (FOLFOX or CAPOX) are the most common adjuvant treatments after curative resection of colorectal cancer (CRC). However, real-world evidence (RWE) of treatment sequence/outcomes for patients with early recurrence CRC after receiving adjuvant chemotherapy are limited. Methods: This retrospective cohort study was based on an administrative database in Japan. The primary objective was to describe the treatment sequence for patients with early recurrence CRC and treated by combination of FOLFIRI and anti-angiogenesis inhibitors (AAIs) or anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs) after adjuvant FOLFOX or CAPOX therapy. The study included patients with CRC who underwent surgical resection, started adjuvant chemotherapy ≤3 months (mo) after the first surgery, had early recurrence of CRC (defined as initiation of FOLFIRI + AAIs/anti-EGFR mAbs second line [2L] regimen) within 1 year after adjuvant chemotherapy ended. Patient characteristics at baseline of 2L (60 days prior to 2L initiation) and treatment sequence were summarized descriptively; time to discontinuation (TTD) for adjuvant and 2L therapy were analyzed using Kaplan-Meier method. Cox proportional hazard model was used to identify risk factors associated with TTD of 2L regimen. Results: The cohort included 832 patients: median (range) age was 67 (24-86) years, 56.4% males, 65.5% with left-sided CRC. Most patients received CAPOX (71.3%) as adjuvant therapy. Median (95% CI) duration of adjuvant therapy was 5.4 mo (5.3-5.5). As 2L therapy, 72.5% and 27.5% of patients received FOLFIRI + AAIs (AAIs group) and FOLFIRI + anti-EGFR mAbs (anti-EGFR group), respectively. Median TTD (95% CI) of the AAIs and anti-EGFR groups in 2L were 6.2 mo (5.8-6.9) and 6.1 mo (5.2-7.4), respectively. Among patients with recurrence within 6 mo (72.6%), the median TTD (95% CI) for AAIs and anti-EGFR groups were 6.1 mo (5.5- 6.5) and 5.8 mo (5.1-7.8), respectively. Among patients with recurrence during 6 to 12 mo (27.4%), the median TTD (95% CI) of AAIs and anti-EGFR groups were 8.1 mo (6.1-9.2) and 6.2 mo (4.6-8.0), respectively. Age ≥70 years was negatively associated with TTD of 2L, HR = 1.19 (95% CI: 1.02-1.39); p=0.03. Conclusions: This is the first RWE based on administrative data on treatment sequence/ outcomes for patients with early recurrence CRC treated by FOLFIRI + AAIs/anti-EGFR mAbs after adjuvant FOLFOX/CAPOX therapy in Japan. The treatment outcomes for patients with early recurrence CRC were similar to previous clinical trials in 2L advanced CRC. The results suggested that these two 2L regimens had similar TTD; however, the timing of relapse may influence the efficacy of AAIs and anti-EGFR mAbs.
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JE, Shitaye, I. Parmova, L. Matlova, L. Dvorska, A. Horvathova, V. Vrbas, and I. Pavlik. "Mycobacterial and Rhodococcus equiinfections in pigs in theCzechRepublicbetween the years 1996 and 2004: the causal factors and distribution of infections in the tissues." Veterinární Medicína 51, No. 11 (March 27, 2012): 497–511. http://dx.doi.org/10.17221/5584-vetmed.
Abstract:
Between 1996 and 2004, tissue samples from 3 630 slaughtered pigs were examined by gross examination, microscopy after the Ziehl-Neelsen (ZN) staining of homogenised tissues for the detection of acid-fast rods (AFR) and by culture for the presence of mycobacteria and Rhodococcus equi: 1 781 head lymph nodes (ln), 1 123 mesenteric ln, 54 pulmonary ln, 32 inguinal ln, 562 non-identified ln and 78 samples of tissues from parenchymatous organs (liver, spleen and kidneys). Tuberculous/tuberculoid lesions were not detected in 249 (6.9%) animals slaughtered due to a positive response to avian tuberculin. Various gross lesions were detected in 3 381 (93.1%) animals as follows: adenopathy in 150 (4.1%), tuberculous lesions with caseation in 2 026 (55.8%) and tuberculous lesions with calcification in 1 205 (33.2%) of them. AFR were found in tissues from 2 047 (56.4%) animals: in 36 (14.5%) animals free from gross lesions, in 28 (18.7%) animals with adenopathy, in 801 (39.5%) animals with caseation and in 913 (75.8%) animals with calcified tuberculous lesions. Mycobacteria were isolated from the tissues of 289 (15.8%) of 1 852 animals without detected AFR and from the tissues of 1 290 (72.5%) of the 1 778 animals with detected AFR of various intensities. Of 1 579 mycobacterial isolates 1 493 (94.6%) were classified as M. avium complex (MAC) members: 469 (29.7%) M. a. avium (IS901+, serotypes 1, 2, and 3) and 891 (56.4%) M. a. hominissuis (IS901–) isolates of serotypes 4 (n = 1), 8 (n = 643), 9 (n = 74) and non-typed (n = 173). The other 52 (3.3%) isolates were members of other mycobacterial species: M. chelonae (n = 35), M. smegmatis (n = 4), M. xenopi (n = 3), M. terrae (n = 7), M. aurum (n = 1), M. scrofulaceum (n = 1), M. fortuitum (n = 1) and biochemically non-identified mycobacteria (n = 34). By examination of ZN stained homogenised tissues, AFR were detected significantly more frequently (P < 0.01) in samples from animals with caseated and/or calcified tuberculous lesions than in tissues from animals without tuberculous lesions. The detection rate of isolates from tissues with tuberculous lesions was likewise significantly higher (P < 0.01) than from tissues without tuberculous lesions.