Journal articles: '617.172 052'

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Isaev, S., T. Rajabov, G. Goziev, and A. Khojasov. "Effect of fertilizer application on the ‘Bukhara-102’ variety of cotton yield in salt-affected cotton fields of Uzbekistan." E3S Web of Conferences 258 (2021): 03015. http://dx.doi.org/10.1051/e3sconf/202125803015.

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In this article, stratified feeding of Bukhara-102 variety of medium-fiber cotton with mineral fertilizers were carried out in the conditions of irrigated and fertile soils of Kashkadarya province. Simultaneously, compared to the studied fertilizer application options, there was a decrease in soil volume by 0.01–0.02 g/cm3, an increase in soil porosity by 0.4–1.2%, and an increase in soil water permeability to 5.8–24.6 m3/ha. Moreover, an additional yield of 1.3–2.6 quintals of cotton, the quality indicators of fiber length that increased by 0.1–0.2%, fiber yield to 0.2–0.5%, the weight of 1, 000 seeds to 1–2 grams , the incidence of Wilt's disease was found to become as low as 6.1–10 %. At the same time, with increasing salinity in the care of saline soils at different levels, the net profit was around 40, 617 - 1, 127, 853 UZS and the profitability rate was 0.8-20.1% lower than expected.

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Ruder, Samuel Francis, Michael Philip Sun, Charlene Thomas, Ana M. Molina, Jones T. Nauseef, Joseph Osborne, Cora N. Sternberg, David M. Nanus, Neil Harrison Bander, and Scott T. Tagawa. "Comparison of adverse event rate of prostate-specific membrane antigen (PSMA)-targeted radionuclide therapy (TRT) with antibody or small molecule ligand targeting vector." Journal of Clinical Oncology 42, no. 4_suppl (February 1, 2024): 161. http://dx.doi.org/10.1200/jco.2024.42.4_suppl.161.

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161 Background: PSMA-targeted radionuclide therapy (PSMA-TRT) has been established with use of either monoclonal antibodies (mAb) or small molecule ligands (SML) as the targeting vectors for delivery of 177Lu to PSMA-expressing prostate cancer. mAb and SML differ in their molecular weight, pharmacokinetics, and biodistribution which is predicted to result in different adverse effect profiles. Methods: In this study with written informed consent, we compare the adverse effects from individual patients receiving PSMA-TRT for mCRPC using mAb (J591) vs SML (PSMA-617 or PSMA I&T) for delivering 177Lu in prospective clinical trials or registry. All-grade treatment-emergent adverse events (TEAEs) were extracted from trial databases. Adverse effects were graded 0-5. Pearson’s Chi-squared test was used to assess TEAEs and association with treatment type. Multivariable logistic regression was used to compare TEAEs after adjusting for administered radioactivity dose and CALGB (Halabi) prognostic score. Results: 248 patients with mCRPC were treated from March 2001 to February 2023. 166 (67.7%) received mAb (177Lu-J591), 81 received SML [76 (30.6%) 177Lu-PSMA-617, 5 (2%) 177Lu-PSMA-I&T)]. The median age was 70.9 years (44.5 yrs to 93.8 yrs). At the time of trial enrollment, 137 (55.2% [68% SML and 49% mAb]) patients had exposure to chemotherapy, 112 (45.1%) had exposure to androgen-receptor pathway therapy, 193 (77.8%) had bone metastases, 120 (48.3%) LN mets, 42 (16.9%) lung mets, and 20 (8.0%) liver mets. 142 (57.2%) had Halabi score high disease. All-grade hematologic TEAEs were more common with mAb: neutropenia in 122 (74%) patients vs 16 (20%) (p<0.001), anemia in 122 (73%) vs 26 (33%) (P<0.001), and thrombocytopenia in 145 (87%) vs 25 (32%) (p<0.001). Gr >3 neutropenia occurred in 79 (47%) and Gr >3 thrombocytopenia in 98 (59%) receiving mAb. All-grade non-hematologic TEAEs were generally more common with SML: fatigue in 31 (53%) vs 79 (48%) (p=0.5), pain in 32 (54%) vs 73 (44%) (p=0.2), nausea in 21 (36%) vs 34 (20%) (p=0.02) and xerostomia in 36 (61%) vs 1 (0.6%) (p<0.001). After adjusting for administered dose and Halabi score, treatment with 177Lu via SML vector was associated with less neutropenia (OR 0.04, 95% CI 0.02-0.09, p<0.001), anemia (OR 0.11, 95% CI 0.06-0.22, p<0.001), and thrombocytopenia (OR 0.04, 95% CI 0.02-0.09, p<0.001) but more nausea (OR 3.2, 95% CI 1.54-6.72, p=0.002) and xerostomia (NA due to low event rate in mAb). Conclusions: As predicted, PSMA-TRT with mAb vs SML is associated with different toxicity profiles. PSMA-TRT with the mAb 177Lu-J591 is more commonly associated with hematologic toxicities compared to the SML 177Lu-PSMA-617 and 177Lu-PSMA-I&T, which are more commonly associated with non-hematologic toxicities.

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V.M, Vishwanath, and Ravishankar R.B. "A Clinical Comparative Study between Epidurally Administered Ropivacaine 0.2 % and Ropivacaine 0.2 % with Clonidine for Post-Operative Analgesia in Lower Limb and Abdominal Surgeries." Journal of Evidence Based Medicine and Healthcare 7, no. 50 (December 14, 2020): 3010–15. http://dx.doi.org/10.18410/jebmh/2020/615.

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BACKGROUND There are many modalities to give postoperative analgesia. Out of them epidural analgesia offers good reliable pain relief. Addition of alpha agonist enhances the onset of analgesia and duration of analgesia is prolonged. This study was done to compare the analgesic efficacy, and the hemodynamic parameters of ropivacaine compared with ropivacaine in combination with clonidine for post-operative epidural analgesia. METHODS 30 patients of age 18 - 70 years with ASA grade of I & II, undergoing elective lower limb and abdominal surgeries were randomly taken into each of the 2 groups. Group R received 0.2 % ropivacaine and group RC received 0.2 % ropivacaine + clonidine (1 mcg / Kg) epidurally.1,2 Patients were monitored for onset, duration, quality of analgesia, cardiorespiratory stability and side effects. RESULTS The onset of analgesia and quality of analgesia were better in the RC group compared to the R group. The duration of analgesia in group RC (9.43 + - 1.17 hours) was found to be significantly prolonged than group R (4.90 + - 1.03 hours) with p < 0.001. Blood pressure was more stable in group RC compared to group R. CONCLUSIONS In this study we found that ropivacaine with clonidine as epidural postoperative analgesia provided superior and more effective analgesia when compared to ropivacaine. The duration of analgesia was significantly longer in group ropivacaine with clonidine. KEYWORDS Ropivacaine, Clonidine, Post-operative Analgesia, Epidural

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Syraeva, G. I., A. S. Kolbin, S. A. Mishinova, and A. A. Kalyapin. "Quantitative and qualitative evaluation of the use of nonsteroidal anti-inflammatory drugs in the Russian Federation over 10 years." Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice, no. 3 (November 14, 2022): 19–30. http://dx.doi.org/10.37489/2588-0519-2022-3-19-30.

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Relevance. Studies devoted to the assessment of consumption, as well as to the issues of pharmacosafety of nonsteroidal anti-inflammatory drugs, are limited at the national level in the Russian Federation. The study of these issues will determine the general trends of consumption and prescription of this group of drugs.Aim. To assess the consumption pattern of NSAIDs in the Russian Federation in the period from 2010 to 2020.Methods. Information was searched using data from the state register of drugs (GRLS) as well as national database downloads (automated information system of Roszdravnadzor; AIS RZN). To estimate the consumption of the main INN from the group of NSAIDs for the period 2010–2020 the information on the sales volume of all trade names, sold for sale in the Russian Federation was unloaded from the database of IQVIA Solutions Ltd. and analyzed.Results. The analysis showed that the first place by total amount of consumption was occupied by acetylsalicylic acid (5 953 058 854); second place — paracetamol (4 635 122 085); third place — ibuprofen (3 230 415 088); fourth place — metamizole (4 172 344 008); fifth place — ketorolac (91 617 809,04); sixth — nimesulide (69 761 7481,8). The claimed INNs showed a slightly different distribution when calculating the DDDs/P (patient-year) totals, namely, in descending order, nimesulide, ketorolac, ibuprofen, acetylsalicylic acid, paracetamol, and methamisole.Conclusion. The indicated levels of consumption do not correlate with the data of the national database “Pharmacovigilance”, which indicates insufficient post-marketing monitoring of the safety profiles of the indicated medicines.

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Sonbol, Mohamad Bassam, Raed Benkhadra, Zhen Wang, Belal Firwana, Kabir Mody, Pashtoon Murtaza Kasi, Joleen Marie Hubbard, M. Hassan Murad, Daniel H. Ahn, and Tanios S. Bekaii-Saab. "A systematic review and network meta-analysis of regorafenib and TAS-102 in refractory metastatic colorectal cancer." Journal of Clinical Oncology 37, no. 4_suppl (February 1, 2019): 619. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.619.

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619 Background: Regorafenib (at a starting dose of 160 mg/day, rego 160), regorafenib (with a weekly dose escalation, rego 80+) and TAS-102, are suggested treatment options for refractory metastatic colorectal cancer (mCRC). We aimed to evaluate the comparative effectiveness evidence supporting these 3 strategies. Methods: We searched PubMed, Embase, and Cochrane CENTRAL, for randomized controlled trials evaluating TAS 102 or regorafenib in refractory mCRC patients who progressed on/intolerant of previous oxaliplatin, irinotecan, and fluoropyrimidine. Outcomes of interest included OS and PFS. The overall effect was pooled using the DerSimonian random effects model. We conducted network meta-analysis based on White’s multivariate meta-regression to pool evidence from direct and indirect comparisons. Results: Six trials (3 of regorafenib and 3 of TAS-102) at low risk of bias (2,445 patients) were included. Direct comparisons showed that Rego 160 and TAS-102 as monotherapy were superior to BSC in terms of PFS (Rego 160: HR = 0.4, CI 0.26 to 0.63; TAS-102: HR = 0.46, CI 0.40 to 0.52) and OS (Rego 160: HR = 0.67, CI 0.48 to 0.93; TAS-102: HR = 0.67, CI 0.57 to 0.80). Network analysis showed that there was no difference in PFS or OS between Rego 160 and TAS-102. Rego 80+ was superior to BSC in terms of OS (HR = 0.44, CI 0.23 to 0.84) and PFS (HR = 0.37, CI 0.21 to 0.66). There was a numerical advantage for Rego 80+ compared to TAS-102 and Rego 160 (see table). Conclusions: Regorafenib 160 and TAS-102 appear to have similar efficacy. Rego 80+ is shown to be superior to BSC. A trend for improved OS was observed with Rego 80+ versus Rego 160 or TAS 102. [Table: see text]

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Enginoev, Soslan T., Dmitriy A. Kondratiev, Gasan M. Magomedov, Tamara K. Rashidova, Bakytbek K. Kadyraliev, Igor I. Chernov, and Dmitriy G. Tarasov. "Effect of preoperative atrial fibrillation on long-term results after Off Pump Coronary Artery Bypass." Perm Medical Journal 38, no. 6 (November 15, 2021): 5–15. http://dx.doi.org/10.17816/pmj3865-15.

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Objective. To study the effect of preoperative atrial fibrillation (AF) on the risk of stroke and long-term mortality after Off Pump Coronary Artery Bypass (OPCAB). Materials and methods. A retrospective analysis of the results of OPCAB in 212 patients with coronary artery disease (CAD), who were operated on from May 2009 to November 2013, was carried out. After propensity score matching, patients were divided into 2 groups: Group I 82 patients with sinus rhythm (SR) before surgery, Group II (control) 102 patients with AF before surgery. The average age of the included patients was 61 6.7 years, with 95 % CI: 6062. Fifty-four (29.3 %) patients were over 65 years of age. There were 162 men (88 %) and 22 women (12 %). The median follow-up was 93.5 (66.7102.0) months. Results. The time spent in the clinic was statistically significantly shorter in the SR group than in the AF group (10 (911) and 14 (1116) hours, respectively, p 0.001). There was no statistically significant difference in the number of perioperative myocardial infarctions (in the group with SR it occurred in 1 (1.2 %) patient, in the group with AF 2 (2 %), p = 0.7), strokes (in the group with SR 1 (1.2 %), in the group with AF 3 (2.9 %), p = 0.6), as well as a 30-day mortality (in the group with SR it was 0 %, in the group with AF 3 (2.9 %), p = 0.2). In the long-term postoperative period, there were statistically significantly fewer strokes in the group with SR than in the group with AF (in the group with SR, the 10-year stroke freedom was 88.8 %, and in the group with AF 71.8 %, p = 0.018), and also better long-term survival in the group with sinus rhythm (in the group with SR, the 10-year survival rate was 79 %, in the group with AF 63.9 %, p = 0.016). Conclusions. In the group with preoperative AF, the frequency of distant strokes and deaths is higher than in patients with sinus rhythm.

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Leznoff, Clifford C., Dmitri S. Terekhov, Colin R. McArthur, Steven Vigh, and Jing Li. "Multisubstituted phthalonitriles, naphthalenedicarbonitriles, and phenanthrenetetracarbonitriles as precursors for phthalocyanine syntheses." Canadian Journal of Chemistry 73, no. 3 (March 1, 1995): 435–43. http://dx.doi.org/10.1139/v95-057.

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Electrophilic aromatic nitration under mild conditions of 4-hydroxyphthalonitrile gave 4-hydroxy-3-nitrophthalonitrile and 4-hydroxy-5-nitrophthalonitrile, while bromination yielded 3-bromo-4-hydroxyphthalonitrile, 4-bromo-5-hydroxyphthalonitrile, and 3,5-dibromo-4-hydroxyphthalonitrile. Iodination gave 4-hydroxy-5-iodophthalonitrile and 4-hydroxy-3,5-diidophthalonitrile. Coupling of 4-iodophthalonitrile, 3-iodophthalonitrile, and 5-iodo-2,3-dicyanonaphthalene with trans-1,2-bis(tri-n-butylstannyl)ethene gave trans-1,2-bis(3,4-dicyanophenyl)ethene, trans-1,2-bis(2,3-dicyanophenyl)ethene, and trans-1,2-bis(6,7-dicyanonaphthyl)ethene. Photocyclization of a dilute solution of cis- or trans-1,2-bis(3,4-dicyanophenyl)ethene in dioxane gave a 1:1 mixture of 2,3,6,7- and 2,3,5,6-tetracyanophenanthrenes separable by chromatography. Keywords: phthalonitriles, naphthalenedicarbonitriles, phenanthrenetetracarbonitriles, electrophilic substitution.

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Pauleit, D., H. Palmedo, H. Bender, J. Bucerius, S. Ezziddin, V. Klein, F. Grünwald, H. J. Biersack, K. Reichmann, and J. H. Risse. "Therapy of hepatocellular carcinoma with 131I-lipiodol: patient dosimetry." Nuklearmedizin 46, no. 05 (2007): 192–97. http://dx.doi.org/10.1160/nukmed-0086.

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SummaryAim: Dosimetry in 131I-lipiodol therapy for hepatocellular carcinoma (HCC) in the hitherto largest existing patient cohort. Patients, methods: 38 courses of intra-arterial 131I-lipiodol therapy with a total activity up to 6.7 GBq were performed in 18 patients with HCC. Liver and tumour volume were measured by computed tomography (CT) and 131I activity by scintigraphy on day 3, 6, 14, 28 and 42 after injection. Lipiodol deposition in tumour nodules as shown by CT rendered definite attachment to scintigraphic data possible. The radiation dose in tumour nodules, liver and lungs was calculated according to the MIRD concept and the tumour dose related to pre-therapeutic tumour volume, response and survival. Results: Mean tumour dose was 23.6 ± 3.6 Gy (14.2 ± 2.1 mGy/MBq) with maximal 162 Gy (90.1 mGy/MBq) after one and 274 Gy after three courses. The dose to nontumourous liver was 1.9 ± 0.2 Gy (1.2 ± 0.1 mGy/MBq) and the mean dose ratio of tumour / nontumourous liver 11.1 ± 1.7 (max. 82). The pulmonary dose was 25.9 ± 1.8 mGy (16.3 ± 1.2 μGy/MBq) and therefore much lower. There was a reciprocal relation between tumour dose and pretherapeutic tumour volume. Tumour dose had no effect on response or survival. Conclusion: High radiation doses are particularly in small tumour nodes achievable but not necessarily related to tumour response. The dose of non-tumourous liver and lungs is much lower.

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Torres Valdiviezo, Lucero Itzel, Karla Lucero Rodríguez Flores, Vanessa Rosas Rosas Camargo, Alejandro Noguez-Ramos, Mónica Isabel Meneses Medina, Ximena Rosas Flota, Armando Gamboa Dominguez, and Fidel David Huitzil Melendez. "Clinical characteristics, treatment, and oncological outcomes in patients with ampullary cancer at a reference center in Mexico." Journal of Clinical Oncology 40, no. 4_suppl (February 1, 2022): 617. http://dx.doi.org/10.1200/jco.2022.40.4_suppl.617.

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617 Background: Ampullary cancer (AC) represents 0.2% of gastrointestinal cancers. Given the rarity of the disease, information regarding treatment strategies and outcomes derives from studies that include the different types of periampullary cancers, which constitute a heterogeneous group. Our aim was to describe the clinical characteristics, treatment modalities and outcomes in patients (pts) with true AC treated at our institution. Methods: A retrospective review of medical records of all consecutive pts with histological diagnosis of AC evaluated at our institution from Jan 2009-Dec 2019. Clinical, pathological and laboratory variables at diagnosis were recorded. Overall survival (OS) was estimated by Kaplan-Meier and compared with the Log-rank test. Statistical significance was determined at P<0.05. Results: 133 pts with AC were included. Median age was 62 yo (IQR 53-70), 51.9% were women. 25% had ampullary adenoma history. Symptoms at diagnosis: 89% jaundice, 63% weight loss and 56% abdominal pain. Median laboratory values were total bilirubin 1.7 mg/dL (0.7-5.1), albumin 3.7 g/dL (3.1-4.2), hemoglobin 12.6 g/dL (10.9-14.2), carbohydrate antigen (CA) 19-9 34.7 U/mL (6.4-113.9) and carcinoembryonic antigen (CEA) 2.6 ng/mL (1.2-4.2). Most tumors were moderately differentiated (59%). Histologic subtypes of adenocarcinoma were available in 84 pts: intestinal 46.4%, pancreaticobiliary 39.3% and mixed 14.3%. Stage at diagnosis was localized (46%), locally advanced N+ (29%) and advanced (25%). For those with localized/locally advanced disease, 91% (91/100) underwent surgical resection, 25.3% (23/91) received adjuvant chemotherapy (ChT), 69.6% (16/23) received single agent and 30.4% (7/23) duplet. Pts who received adjuvant Cht presented N+ in 69.6%, moderate differentiation in 73.9%, intestinal 47.8% and pancreaticobiliary subtype 43.5%. In advanced setting, 63.6% (21/33) received palliative Cht, 66.7% received a duplet regimen. Median OS was 32.8 (22.9-42.8) months (mos). Median OS according to stage was 152.1, 28.1 and 10.2 mos for localized, locally advanced, and advanced, respectively (P<0.001). OS univariate analysis is shown in table. Conclusions: Most of pts presented with localized/locally advanced disease, were eligible to surgical resection and had a better survival. For those with N+ disease it is required to evaluate the role of adjuvant Cht. In the advanced setting, Cht improves prognosis.[Table: see text]

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Vakulchyk, V. G., and A. V. Khudovtsova. "CLINICAL SIGNIFICANCE OF POLYMORPHONUCLEAR NEUTROPHILS IN THE STRATIFICATION OF CHILDREN WITH ACUTE ABDOMINAL PAIN." Journal of the Grodno State Medical University 20, no. 6 (December 30, 2022): 607–12. http://dx.doi.org/10.25298/2221-8785-2022-20-6-607-612.

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Background. Acute abdominal pain in children is defined as acute pain of non-traumatic genesis lasting up to 5-7 days, and presents a serious diagnostic and tactical problem. Many aspects of diagnosis and treatment remain controversial. Aim. To determine the clinical significance of polymorphonuclear neutrophil count in the stratification of children with acute abdominal pain. Material and Methods. A prospective randomized blind clinical trial was performed. The results of examination and treatment of 633 children admitted to Grodno Regional Children's Clinical Hospital with acute abdominal pain were analyzed. The number of polymorphonuclear neutrophils was analyzed in relative (PNRV) and absolute (PNAV) values. Statistics included evidence-based criteria, ROC and precision-recall curve analysis, Kullback's measure of informativeness (Jxi), Bayes' theorem. Results. Separation points were determined for the PNRV and PNAV tests. It was 65% for the PNRV test and 8.952×109/L for the PNAV test. For PNRV values less than 65%, the probability of acute appendicitis (AA) as a cause of acute abdominal pain was 1.8% (CI 0.2 to 3.4); the overall informative value was 2.94. With PNAV test values less than 6.5×109/L, the probability of AA was 1.2% (CI 0.03 to 2.4%); the overall informative value was 5.24. It was demonstrated that an increase in test values above the indicated values did not significantly increase the probability of AA as a cause of acute abdominal pain in children. Conclusion. The tests studied are highly informative and can be used to stratify patients with acute abdominal pain. It is necessary to validate the results obtained taking into account the specific capabilities of a given medical institution and the type of equipment used.

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Leckett, Blaine, and Ralph J. Germinario. "Inability of insulin and insulinlike growth factor-1 to stimulate sugar or amino acid transport and thymidine incorporation in cultured myeloma cells." Biochemistry and Cell Biology 69, no. 12 (December 1, 1991): 859–63. http://dx.doi.org/10.1139/o91-127.

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NS-1 mouse plasmacytoma cells were examined for their insulin and insulinlike growth factor-1 (IGF-1) binding characteristics and ability to produce peptide-dependent cellular effects. At concentrations of labelled insulin (i.e., 1.7 × 10−10 M) or IGF-1 (i.e., 1.5 × 10−10 M), NS-1 cells specifically bind 0.2 ± 0.06 fmol insulin per 106 cells (n = 7), where little, if any, IGF-1 specific binding was observed (0.02 ± 0.01 fmol/106 cells) (n = 3). Additionally, the data indicate that the total number of insulin binding sites per cell was 3200 ± 390 (n = 3). Insulin was employed at various concentrations (6.7–667 nM) and failed to stimulate either sugar or amino acid transport. Insulin at low concentrations (i.e., 6.7 or 67 nM) did not stimulate DNA synthesis, yet a small but significant increase was observed at a concentration of 667 nM insulin. IGF-1 did not stimulate DNA synthesis at all concentrations employed (1.4–143 nM). In summary, there exists a small but significant number of insulin receptors, little insulin-stimulated DNA synthesis, and no apparent insulin stimulation of sugar or amino acid transport. Also, since there is no significant IGF-1 binding and no IGF-1 stimulation of DNA synthesis, these findings indicate that this cell line might be a good candidate for the study of insulin receptor function as a transfection recipient of insulin receptor genes.Key words: cultured myeloma cells, insulin and IGF-1 binding and action, sugar transport, amino acid transport, DNA synthesis.

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Ali, Maisa, Faraj Alhowady, Waqar Munir, Muna Almaslamani, Abdulatif Alkhal, Zubiada Alswaidi, and Hisham Ziglam. "800. Drug-Resistant TB: An Experience From Qatar." Open Forum Infectious Diseases 5, suppl_1 (November 2018): S287. http://dx.doi.org/10.1093/ofid/ofy210.807.

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Abstract Background Drug-resistant tuberculosis (DR-TB) is an important issue for public health. This study was conducted to evaluate the characteristics, treatment outcome, and risk factors associated with 223 DR-TB cases in the State of Qatar. Methods A descriptive records-based retrospective study was conducted on patients registered at Communicable Disease Centre (CDC), Qatar to all consecutive microbiologically confirmed tuberculosis cases for the period January 2010–March 2015. Demographic and clinical data extracted included: patient’s age, sex, and country of origin; disease site (pulmonary or extra-pulmonary); presence of comorbidities, HIV/AIDS status, previous chemoprophylaxis and/or previous treatment for TB, and anti-TB drug resistance the resistance pattern of isolated mycobacteria. The sputum culture conversion rate and treatment outcome was assessed for the patient who completed their treatment in Qatar Results Of 3,301 patients with positive M. tuberculosis culture were analyzed; 223 (6.7%) were resistant to one or more first-line drugs, to isoniazid in 3.1% (n = 102), streptomycin in 1.2% (n = 41), rifampicin in 0.2% (n = 6), ethambutol in 0.15% (n = 5), and multi-drug resistance in 1.2% (n = 38) of patients. Among the resistant TB patients, more common demographic characteristics were former resident of Indian subcontinent (64.1%). A history of anti-TB treatment was not a risk factor with drug resistance in our cohort. Only 111 (49.7%) patients were tested for HIV antibodies and the results were all negative. There was significant correlation between the type of drug-resistance and CXR finding (23.3% had cavity—P = 0.019). Sputum culture conversion to negative at 2 month of therapy was 94% (n = 101), whereas 122 cases lost follow-up. The outcome of treatment was assessed for 85 resistant cases with follow-up after completion of treatment, show cure rate of 97.6%, and relapse of 2.4%. However, 137 cases (61.4% from total) they left the country before completion of therapy. Conclusion Drug-resistant TB in Qatar is influenced by migration, especially from the Indian subcontinent, where the patients were probably infected. Rapid sputum sampling performed in the early stages of the disease, patient isolation, and drug susceptibility testing should be the standard of care to avoid further transmission and improve TB control. Disclosures All authors: No reported disclosures.

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Santos Filho, Serafim Barbosa, and Sandhi Maria Barreto. "Atividade ocupacional e prevalência de dor osteomuscular em cirurgiões-dentistas de Belo Horizonte, Minas Gerais, Brasil: contribuição ao debate sobre os distúrbios osteomusculares relacionados ao trabalho." Cadernos de Saúde Pública 17, no. 1 (February 2001): 181–93. http://dx.doi.org/10.1590/s0102-311x2001000100019.

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Estudo de prevalência de dor osteomuscular e fatores associados ao sintoma em cirurgiões-dentistas (n = 358), utilizando-se de questionário auto-aplicável, com dados sócio-demográficos, ocupacionais, psicossociais, hábitos de vida, localização e características de dor. 92% dos dentistas selecionados participaram do estudo. A prevalência de dor no segmento superior foi de 58%: 22% de dor no braço, 21% na coluna, 20% no pescoço e 17% no ombro; 26% relataram dor diária e 40% dor moderada/forte. Na análise multivariada (regressão logística múltipla), os fatores associados à dor foram: Pescoço: ansiedade/depressão (RC = 2,3; IC95%: 1,2-4,5), ruído-compressor (RC = 2,1; IC95%: 1,2-3,7), satisfação no trabalho (RC = 0,3; IC95%: 0,1-0,9) e uso de visão indireta (RC = 0,5; IC95%: 0,3-0,9); ombro: renda > 20 salários (RC = 2,9; IC95%: 1,2-6,7), maior produtividade (RC = 3,3; IC95%: 1,3-8,4), altura > ou = 160cm (RC = 0,3; IC95%: 0,2-0,7) e idade 30-49 anos (RC = 0,3; IC95%: 0,1-0,8); coluna: ansiedade/depressão (RC = 2,3; IC95%: 1,2-4,5), atividade manual (RC = 0,4; IC95%: 0,2-0,9) e ser casado (RC = 0,5; IC95%: 0,3-0,9); braços: atividade manual (RC = 1,8; IC95%: 1,0-3,2).

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Andriani, Alessandro, Roberto Latagliata, Michele Cedrone, Ambra Di Veroli, Cristina Santoro, Francesca Spirito, Carla Ruscio, et al. "Are ET and PV Patients Two Similar Populations As Concern Thrombotic Risk Factors?" Blood 126, no. 23 (December 3, 2015): 2811. http://dx.doi.org/10.1182/blood.v126.23.2811.2811.

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Abstract Thrombotic events are major complications in patients (pts) affected by Essential Thrombocytemia (ET) and Polycytemia Vera (PV). To compare thrombotic risk in these 2 groups, we evaluated retrospectively our database of 1249 ET and 623 PV pts diagnosed and followed in 11 hematological centers in the Latium region between 1/1980 and 12/2010: the diagnosis was done according to PVSG, WHO 2001 and 2008criteria based on the time of first observation. Baseline features of ET pts: 797F/452M,median age 62.9 yrs (range 19-96),median WBC count 8.8 x 109/L (range 1.2-57.7), median PLT count 812 x 109/L (range 457-3582), median Hb level 14.0 g/dl (range 6-20.5), JAK-2V617F positivity 59.7% with a median allele burden of 19,6% (range 0.2- 99.9), spleen enlargement in 18.7% of pts, previous thrombosis223/1239 evaluable pts (17.9%) [arterial 176/223 (14.1%), venous 47/223 (3.8%)]. Baseline features of PV pts: 289F/334M, median age 63.0yrs (range 21-91), median WBC count 10.1 x 109/L (range 3.5-37.6), median PLT count 457 x 109/L (range 169-1790), median Hb level 18.2 g/dl (range 10.5-24.8), JAK-2V617F positivity 94.3% with a median allele burden of 59.1% (range 0.3-99.9), spleen enlargement in 42% of patients, previous thrombosis 146/617 evaluable pts (23.7%)[arterial 114/617 (18.5%), venous 32/617 (5,2%)].in the ET cohort, after a median follow-up of 7.7 yrs, thrombotic complications were seen in 107/1141 evaluable pts (9.4%) [arterial60 (5.25%), venous 47 (4.11%)]; in the PV cohort, after a median follow-up of 8.5 yrs, thrombotic complications were seen in 107/623pts (17.2%) [arterial 67 (10.8%),venous 40 (6.4%)].All common risk factors for thrombosis were evaluated in multivariate analysis, searching the cut-off number for continuous variables with ROC curves. The significant variables at multivariate analysis for ET and PV pts are shown in the table; age, previous thromboses and spleen enlargement were risk factors in ET pts, while previous thromboses and JAK-2V617F allele burden were risk factors in PV pts. PLT count above ROC value seemed to be a protective factor in both cohorts. In conclusion, in contrast with the tendency to evaluate in a similar manner the thrombotic risk of PV and ET, data from our retrospective database showed that these 2 groups should be considered populations with different risk factors for thrombosis. Table 1.Putative prognostic factorsPolycythemia VeraEssential ThrombocythemiaHR95% C.I.pHR95% C.I .pPrevious thromboses2,311,13 - 4,740,021,871,08 -3,230,026Age ≥ 60 y1,540,79 - 2,990,211,901,18 - 3,060,009JAK2V617FPV: allelic burden ≥ 81% ET: pos1,951,03 - 3,710,040,760,48 - 1,210,25Plt countPV ≥ 452.109/L ET ≥ 944.109/L0,490,25 - 0,950,040,520,31 - 0,890,017Spleen enlargement0,670,34 -1,310,241,711,02 - 2,890,04CV risk factors (at least 1)0,920,41 - 2,030,830,870,51 - 1,490,62WBCPV ≥ 10,175.109/L ET ≥ 9,630.109/L1,090,57 - 2,080,801,410,89 -2,260,15 Disclosures No relevant conflicts of interest to declare.

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Fettke, Heidi, Louise Kostos, James Buteau, Jason A. Steen, Elizabeth Medhurst, Mo B. Haskali, Declan Murphy, et al. "Abstract 5614: Genomic aberrations in circulating tumor DNA (ctDNA) and clinical outcomes from [177Lu]Lu-PSMA-617 in metastatic castration-resistant prostate cancer (mCRPC)." Cancer Research 83, no. 7_Supplement (April 4, 2023): 5614. http://dx.doi.org/10.1158/1538-7445.am2023-5614.

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Abstract [177Lu]Lu-PSMA-617 (LuPSMA) radionuclide therapy improves overall survival in mCRPC, and was recently approved by the FDA. Nevertheless, owing to the heterogeneous nature of mCRPC, responses to LuPSMA therapy can be variable, and resistance is inevitable. As a result, biomarkers linked to clinical outcome with LuPSMA are urgently required. Using plasma ctDNA, we present the first comprehensive genomic analysis of a prospective cohort of mCRPC patients treated with LuPSMA. Targeted sequencing of 78 genes was performed on baseline plasma and matched buffy coat samples from patients who received LuPSMA on a prospective registry (NCT04769817). Reportable alterations included pathogenic single-nucleotide and copy number variants. Association between alterations and clinical outcomes were assessed using log rank, cox proportional, and chi-squared analyses. Clinical data collected included PSA decline by ≥50% or ≥90% (PSA50-response rate, PSA50-RR; and PSA90-RR), and PSA progression free survival (PSA-PFS). In total, 100 patients (median age 74 years, range 52-90) received a median of 4 cycles of LuPSMA. 83 patients had detectable ctDNA (median fraction 17%, range 0-94%) with PSA50-RR 50%, PSA90-RR 22%, and a median PSA-PFS of 7.2 months. Patients with an AR or PTEN aberration had significantly shorter PSA-PFS (HR 0.50 and 0.59, respectively; Table), as did patients with any PI3K pathway aberration (HR 0.56). Additionally, patients with a high ctDNA burden had significantly worse PSA-PFS (HR 0.42, Table). There were no significant differences in PSA-RR based on deleterious genomic changes. Our data reveal that aberrations in the AR and PI3K pathways, along with pre-treatment ctDNA fraction, whilst not linked to PSA-RR, are prognostic for durability of response to LuPSMA. If validated in larger cohorts, these data will help to optimise the use of LuPSMA by improving patient selection and enhancing prognostication. Analysis of clinical endpoints based on deleterious genomic changes in ctDNA n PSA-PFS (months, wild type (wt) vs variant) PSA-PFS HR (95% CI, wt vs variant) PSA50-RR (wt vs variant) PSA90-RR (wt vs variant) Exonic AR variants 47 8.1 vs 6.0 p=0.005 0.50 (0.30-0.83) p=0.006 58% vs 40% p=0.09 23% vs 21% p=0.8 Any AR variant (intronic and upstream enhancer regions included) 49 8.1 vs 6.0 p=0.007 0.53 (0.31-0.83) p=0.008 60% vs 41% p=0.09 24% vs 20% p=0.7 RB1 variant 19 7.9 vs 5.5 p=0.2 0.67 (0.39-1.2) p=0.2 51% vs 42% p=0.5 23% vs 21% p=0.9 PTEN variant 25 7.8 vs 6.3 p=0.04 0.59 (0.36-1.00) p=0.045 50% vs 48% p=0.9 22% vs 24% p=0.8 TP53 variant 43 8.1 vs 6.7 p=0.1 0.67 (0.42-1.1) p=0.1 52% vs 47% p=0.6 20% vs 26% p=0.5 BRCA2 variant 10 7.7 vs 5.1 p=0.2 0.63 (0.29-1.30) p=0.2 51% vs 40% p=0.7 20% vs 40% p=0.1 PIK3CA variant 8 7.7 vs 4.1 p=0.08 0.48 (0.20-1.1) p=0.09 52% vs 13% p=0.06 23% vs 13% p=0.5 PI3K pathway variant 35 7.8 vs 5.5 p= 0.02 0.56 (0.34-0.91) p=0.02 55% vs 40% p=0.2 22% vs 23% p=0.9 ctDNA fraction ≥20% 43 9.0 vs 5.1 p=0.0002 0.42 (0.26-0.67) p<0.001 55% vs 42% p=0.2 21% vs 23% p=0.8 Citation Format: Heidi Fettke, Louise Kostos, James Buteau, Jason A. Steen, Elizabeth Medhurst, Mo B. Haskali, Declan Murphy, Maria Docanto, Patricia Bukczynska, Nicole Ng, Shahneen Sandhu, Siavash Foroughi, Luc Furic, Tu Nguyen-Dumont, Michael S. Hofman, Arun A. Azad. Genomic aberrations in circulating tumor DNA (ctDNA) and clinical outcomes from [177Lu]Lu-PSMA-617 in metastatic castration-resistant prostate cancer (mCRPC). [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5614.

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Chu, Chang An, Pietro Galassetti, Kayano Igawa, Dana K. Sindelar, Doss W. Neal, Mark Burish, and Alan D. Cherrington. "Interaction of free fatty acids and epinephrine in regulating hepatic glucose production in conscious dogs." American Journal of Physiology-Endocrinology and Metabolism 284, no. 2 (February 1, 2003): E291—E301. http://dx.doi.org/10.1152/ajpendo.00565.2001.

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To determine the effects of an increase in lipolysis on the glycogenolytic effect of epinephrine (EPI), the catecholamine was infused portally into 18-h-fasted conscious dogs maintained on a pancreatic clamp in the presence [portal (Po)-EPI+FFA, n = 6] and absence (Po-EPI+SAL, n = 6) of peripheral Intralipid infusion. Control groups with high glucose (70% increase) and free fatty acid (FFA; 200% increase; HG+FFA, n = 6) and high glucose alone (HG+SAL, n = 6) were also included. Hepatic sinusoidal EPI levels were elevated (Δ568 ± 77 and Δ527 ± 37 pg/ml, respectively) in Po-EPI+SAL and EPI+FFA but remained basal in HG+FFA and HG+SAL. Arterial plasma FFA increased from 613 ± 73 to 1,633 ± 101 and 746 ± 112 to 1,898 ± 237 μmol/l in Po-EPI+FFA and HG+FFA but did not change in EPI+SAL or HG+SAL. Net hepatic glycogenolysis increased from 1.5 ± 0.3 to 3.1 ± 0.4 mg · kg−1 · min−1( P < 0.05) by 30 min in response to portal EPI but did not rise (1.8 ± 0.2 to 2.1 ± 0.3 mg · kg−1 · min−1) in response to Po-EPI+FFA. Net hepatic glycogenolysis decreased from 1.7 ± 0.2 to 0.9 ± 0.2 and 1.6 ± 0.2 to 0.7 ± 0.2 mg · kg−1 · min−1by 30 min in HG+FFA and HG+SAL. Hepatic gluconeogenic flux to glucose 6-phosphate increased from 0.6 ± 0.1 to 1.2 ± 0.1 mg · kg−1 · min−1( P < 0.05; by 3 h) and 0.7 ± 0.1 to 1.6 ± 0.1 mg · kg−1 · min−1( P < 0.05; at 90 min) in HG+FFA and Po-EPI+FFA. The gluconeogenic parameters remained unchanged in the Po-EPI+SAL and HG+SAL groups. In conclusion, increased FFA markedly changed the mechanism by which EPI stimulated hepatic glucose production, suggesting that its overall lipolytic effect may be important in determining its effect on the liver.

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Anuforo, Henry Uzoma, Toochukwu Ekwutosi Ogbulie, Angela Chika Udebuani, and Ethelbert Uchechukwu Ezeji. "Synthesis of Zinc Oxide Nanoparticles using Extract of Cynodon dactylon and Assessment of their Biological Activity against Staphylococcus aureus and Escherichia coli." UMYU Journal of Microbiology Research (UJMR) 8, no. 2 (December 30, 2023): 74–85. http://dx.doi.org/10.47430/ujmr.2382.009.

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Nanotechnology is a groundbreaking technology that that has been widely applied in creating materials which are useful in various fields. It's important to maintain eco-friendly approaches for synthesis of nanoparticles by diversifying the substrate sources. In this study, the researchers used aqueous extract of Cynodon dactylon to synthesize zinc oxide nanoparticles (ZnONPs). Quantitative phytochemical analysis of the extract showed high concentrations of alkaloids, flavonoids, carbohydrates, proteins, amino acids, and phenolic compounds. In contrast, moderate concentrations of tannins, oils, and fats, and low concentrations of phlorotannins, saponin, triterpenoids, and cardiac glycosides were found. Sterols, anthraquinone glycosides, gums, and mucilages were not detected in the extract. The synthesized ZnONPs showed absorbance ranging from 293 nm to 336 nm, with a peak at 307 nm. Fourier transform infrared (FTIR) spectroscopy revealed that the surface of the ZnONPs contained alcohol (intermolecular bonded), alkyne, amine salt, alkane, alkyne, aromatic compounds, conjugated alkene, amine, nitro compound, sulfonyl chloride, alkylaryl ether, and sulfoxide. Dynamic light scatering (DLS) analysis of the ZnONPs showed that its average size was 35.34±1.64 nm, and the polydispersity index was 0.6335. Spectrum of X ray diffraction indicated that peaks formed at 2θ and their corresponding orientation planes are 31.92o (100), 34.62o (002), 36.44o (101), 47.64o (102), 56.84o (110), 63.3o (200), and 68.16o (112). Transmission electron micrograph revealed the spherical shape, and nonuniform sizes of ZnONPs, which ranged from 0.52 nm to 8.32 nm. Antibacterial analysis of biosynthesized ZnONPs recorded 16±3.2 mm and 6.0±2.2 mm; 6.7±2.1 mm and 4.33±1.3 mm, 0.0±0.0 mm and 1.0±1.41 mm, against Staphylococcus aureus and Escherichia coli, at 53.3 mg/mL, 26.7 mg/mL and 13.3 mg/ml concentrations, respectively. At sub-inhibitory concentrations, biosynthesized ZnONPs demonstrated effective dose-dependent antibiofilm formation activity against E. coli and S. aureus. Consequently, extract of Cynodon dactylon is suitable for biosynthesis of ZnONPs with effective antibacterial and antibiofilm formation activities.

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Chiu, Jen-Hwey, Chien-Hue Ju, Li-Hwa Wu, Wing-Yiu Lui, Chew-Wun Wu, Ming-Shi Shiao, and Chuang-Ye Hong. "Cordyceps sinensisIncreases the Expression of Major Histocompatibility Complex Class II Antigens on Human Hepatoma Cell Line HA22T/VGH Cells." American Journal of Chinese Medicine 26, no. 02 (January 1998): 159–70. http://dx.doi.org/10.1142/s0192415x9800021x.

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Previous studies suggest that down-regulation of the major histocompatibility complex (MHC) antigens on the cell surface of certain tumors results in an escape of immune surveillance. Cordyceps sinensis is well known for its modulatory effect on host immune system. To investigate the modulatory effect of Cordyceps sinensis on MHC class II antigen expression on hepatoma cells, immunostaining with monoclonal antibody (MAb) L243, against the HLA DR region of MHC class II antigens on human hepatoma cell line HA22T/VGH was analyzed by using flow cytofluorimetry. The degree of fluorescence intensity on L243 (+) cells was expressed as relative mean fluorescence intensity (RMFI). The extract of Cordyceps sinensis (VGH-CS-ME-82, 40 μg/ml) was found to increase the MHC class II antigen expression on HA22T/VGH cells with the percentage of L243 (+) cells 40.2 ± 2.5 and RMFI 6.6 ± 0.4; whereas cells without treatment disclosed the percentage of L243 (+) cells 17.2 ± 1.4 and RMFI 5.4 ± 0.3, respectively (p < 0.05). There was a dose-related increase in the degree of fluorescence intensity in terms of RMFI on VGH-CS-ME-82 induced cells. The RMFI in cells treated with IFN-γ0, 0.2 and 5 ng/ml were 5.4 ± 03, 8.2 ± 0.4, and 24.9 ± 1.5, respectively; whereas the RMFI in cells co-incubated with VGH-CS-ME-82 (40 μg/ml) and IFN-γ0, 0.2 ng/:ml and 5 ng/ml were 6.7 ± 0.2 (p <0.05), 9.2 ± 0.9 (p < 0.1) and 29.5 ± 1.2 (p < 0.005), respectively. We conclude that VGH-CS-ME-82, either alone or with IFN-γ induction, increases the MHC class II antigen expression on hepatoma cell line HA22T/VGH, which will shed light into the present immunotherapy, and make the host immune surveillance more effective against tumor cells with down-regulated MHC class II antigen expression.

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Rai, Bharat, Ajaya K. Khadka, and Gyan M. Adhikari. "Factors Affecting Purchasing Behavior in Buying of Passenger Cars." Molung Educational Frontier 14 (July 22, 2024): 46–72. http://dx.doi.org/10.3126/mef.v14i01.67893.

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This study is about the consumer behavior in buying of passenger cars in Nepal. It aimed to identify the factors affecting the consumer behavior in car purchase. It used primary data, which came from a structured questionnaire on the six-point Likert scale that was sent to Nepalese car owners. Kathmandu was chosen as the sample site for our convenience to reach. Primary data was collected through the structured questionnaire. 411 car users were the sample size. SPSS software was used to prepare and look at the data. Through the path analysis, the effect of attributes, price, appearance, self-congruity, and brand personality on consumer buying behavior was examined using the structural equation modeling. The study found that there is significant positive impact of product attributes (β=.175, p=.012) on consumer behavior. It is also discovered that there is a significant positive effect of brand personality (β=.152, p=.032) and self-congruity (β=.619, p=.000) on consumer choice behavior but it was found that the product price (β=.073, p=.271) and product appearance (β=.084, p=.180) have no significant influence on consumer buying behavior towards passenger cars in Nepalese market. The study's results show how future researchers and business people can look at the new conditions for market growth.

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Mantha, Simon, Debra Goldman, Sean M. Devlin, Ju-Whei Lee, Diana Zannino, Dan Douer, Harry J. Iland, et al. "Determinants of Fatal Bleeding during Induction Therapy for Acute Promyelocytic Leukemia in the ATRA Era." Blood 124, no. 21 (December 6, 2014): 948. http://dx.doi.org/10.1182/blood.v124.21.948.948.

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Abstract Background Acute promyelocytic leukemia (APL) is commonly complicated by complex coagulopathy. The early use of all-trans retinoic acid (ATRA) appears to have reduced induction mortality; however, with modern regimens the risk of early hemorrhagic death remains at about 5-10% in clinical trials and up to 30% in population-based studies. Previously identified as markers of bleeding risk in this setting are: white blood cell count (WBC), peripheral blood blast count, platelet count, fibrinogen, prothrombin time (PT), activated partial thromboplastin time (aPTT) and creatinine. Nonetheless, uncertainty remains as to which ones are independent predictors. Materials and Methods The database for study was from APL patients enrolled on three large clinical trials that used ATRA for induction: APML3 (single arm of ATRA + idarubicin ± prednisone), APML4 (single arm of ATRA + idarubicin + arsenic trioxide + prednisone) and ECOG 2491 (intergroup I0129, consisting of daunorubicin + cytarabine vs ATRA). Known determinants of bleeding were assessed at baseline and considered as potential predictors of hemorrhagic death in the first 30 days of induction. In univariate analysis, using Wilcoxon Rank Sum and Fisher’s exact test, we looked at the association of the parameters mentioned above with hemorrhagic death within 30 days of induction. Results A total of 619 patients were enrolled: ECOG 2491 (intergroup I0129) - 394, APML3 - 101, and APML4 -124. Among these, thirty (4.8%) deaths from bleeding during the first 30 days (early deaths, ED) following induction were recorded. Baseline characteristics of the patients are shown in Table 1 and Table 2. Initial coagulation parameters (PT, aPTT and fibrinogen) were not available for the ECOG trial. Parameters with significant differences between the ED cases and the remaining of the cohort included WBC (median: 7.4 vs 2.4 /Kmcl respectively, p<0.001), peripheral blood blast count (median: 1.0 vs 0.2 /Kmcl respectively, p=0.049) and platelet count (median: 20 vs 33 /Kmcl respectively, p=0.002). Conclusions In this large cohort of approximately 600 APL patients enrolled on 3 large clinical trials, higher WBC, peripheral blast count and lower platelet count emerged as univariate predictors of early hemorrhagic death. Surprisingly, age, PT, aPTT, fibrinogen and creatinine clearance did not differ between the patients who died from bleeding and the remaining of the cohort. Multivariate analysis will clarify the relative strength of the significant predictors in assessing ED, and will be available, along with coagulation parameters for ECOG, at the time of presentation. These data hopefully will allow us to build a clinical prediction rule to identify patients at the highest risk of early hemorrhagic death. Such a stratification tool could prove useful in future trials testing novel approaches to treat the coagulopathy associated with APL. : Abstract 948. Table 1 Baseline Characteristics of Patients, Continuous Variables Variable Total Death from Bleeding within 30 days No Yes N Median (IQR) N Median (IQR) N Median (IQR) p-value Age (years) 619 40.0 (26.0 - 54.0) 589 40.0 (26.0 - 54.0) 30 47.0 (26.0 - 63.0) 0.15 White Blood Cell Count (K/mcL) 611 2.5 (1.2 - 8.2) 582 2.4 (1.1 - 7.6) 29 7.4 (3.1 - 20.7) <0.001 Peripheral blood blast count (K/mcL) 581 0.2 (0.0 - 2.2) 552 0.2 (0.0 - 1.9) 29 1.0 (0.1 - 5.7) 0.049 Hemoglobin (g/dL) 615 9.3 (8.0 - 10.5) 585 9.3 (7.9 - 10.5) 30 9.4 (8.2 - 10.7) 0.75 Platelets (K/mcL) 615 31.0 (17.0 - 56.0) 585 33.0 (17.0 - 57.0) 30 20.0 (13.0 - 34.0) 0.002 Prothrombin time (s) 184 16.0 (13.3 - 18.2) 179 16.0 (13.3 - 18.1) 5 16.7 (16.5 - 144.3) 0.15 Activated partial thromboplastin time (s) 225 29.0 (26.0 - 32.0) 216 29.0 (26.0 - 32.0) 9 31.2 (29.0 - 38.0) 0.07 Fibrinogen (mg/dL) 217 1.8 (1.3 - 2.6) 208 1.8 (1.3 - 2.6) 9 2.3 (2.0 - 2.5) 0.36 Creatinine Clearance (mg/dL)* 225 389 (261.2 - 511.6) 216 392 (264.9 - 512.4) 9 262 (219.2 - 432.0) 0.15 *calculated using the Jelliffe formula : Table 2 Baseline Characteristics of Patients, Categorical Variables. Variable Total Death from Bleeding within 30 days No Yes N % N % N % p-value ECOG Performance Status 579 93.54 552 93.72 27 90.00 0.50 Good(0-2) Poor(3-4) 36 5.82 33 5.60 3 10.00 Missing 4 0.65 4 0.68 0 0 FAB Classification 248 40.06 239 40.58 9 30.00 >0.95 M3 M3v 67 10.82 65 11.04 2 6.67 Missing 304 49.11 285 48.39 19 63.33 Disclosures No relevant conflicts of interest to declare.

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Altaher, Al-Hussein, Maha Hamoudi, Ghassan Abdul-Majeed, and Faleh Almahdawi. "Enhancing Oil Production Rate by Well Type Conversion in an Iraqi Field." Iraqi Geological Journal 57, no. 2A (July 31, 2024): 249–66. http://dx.doi.org/10.46717/igj.57.2a.18ms-2024-7-28.

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Horizontal wells have been drilled worldwide for the past decades, mainly to increase well’s deliverability. Many vertical wells have been converted to horizontal wells. Only some of them were successful in increasing the oil production rate as expected. In this study, a vertical well (V1) in Kirkuk field was studied and converted to a designed horizontal well (H1) to increase the productivity. PROSPER software was used to model both wells. H1 was designed with well horizontal lengths of 152, 305, 457, and 610 m, and permeability ratios of 0.1, 0.2, 0.4, 0.7 and 1.0. A developed correlation for calculating well construction cost, along with Questor software, were used to perform the economic analysis. It was found that the highest productivity index and production rate ratios were 5.2 and 2.41, respectively. Reservoir pay thickness and permeability ratio are the main parameters in determining the minimum feasible horizontal well length. Reservoir pressure and water cut were found to be the most sensitive parameters in both wells. The net profit generated by a horizontal well with length of 610 m and permeability ratio of 0.2 is 1.9 folds the net profit generated by a vertical well, in three years.

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Giordano, M., P. Castellino, E. L. McConnell, and R. A. DeFronzo. "Effect of amino acid infusion on renal hemodynamics in humans: a dose-response study." American Journal of Physiology-Renal Physiology 267, no. 5 (November 1, 1994): F703—F708. http://dx.doi.org/10.1152/ajprenal.1994.267.5.f703.

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We evaluated the dose-response relationship between the plasma amino acid (AA) concentration and renal hemodynamics in eight normal subjects. After an overnight fast, a balanced 10% AA solution was infused for 180 min at five separate infusion rates: 0.5 (group I), 1.0 (group II), 2.0 (group III), 4.0 (group IV), and 6.0 (group V) ml.kg-1.min-1 on separate days. Basal plasma AA concentration was 1.87 +/- 0.1 mmol/l and increased to 2.26 +/- 0.1 (group I), 2.66 +/- 0.2 (group II), 3.79 +/- 0.5 (group III), 5.81 +/- 0.4 (group IV), and 7.41 +/- 0.4 mmol/l (group V). Basal glomerular filtration rate (GFR) and renal plasma flow (RPF) averaged 95 +/- 4 and 476 +/- 29 ml.1.73 m-2.min-1, respectively, and rose to 98 +/- 5 and 506 +/- 40 (group I) [P = not significant (NS)], 102 +/- 3 and 533 +/- 30 (group II) (P < 0.05 vs. basal), 110 +/- 4 and 567 +/- 29 (group III), 115 +/- 7 and 610 +/- 55 (group IV), and 117 +/- 7 and 614 +/- 66 ml.1.73 m-2.min-1 (group V) (P = NS vs. group IV). Basal plasma glucagon concentration averaged 68 +/- 10 pg/ml and increased to 74 +/- 10 (group I), 83 +/- 11 (group II) (P < 0.05 vs. basal), 100 +/- 14 (group III), 121 +/- 14 (group IV), and 229 +/- 35 pg/ml (group V) (P < 0.01 vs. basal). Increases in plasma growth hormone (GH) and insulin levels were observed only during groups IV and V.(ABSTRACT TRUNCATED AT 250 WORDS)

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Zhang, Zengfeng, Zeqiang Zhan, and Chunlei Shi. "International Spread of Tet(X4)-Producing Escherichia coli Isolates." Foods 11, no. 14 (July 7, 2022): 2010. http://dx.doi.org/10.3390/foods11142010.

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Tigecycline resistance in bacteria has become a significant threat to food safety and public health, where the development of which is attributed to plasmid-mediated tet(X4) genes. In this study, the genomes of 613 tet(X4)-producing Escherichia coli (E. coli) isolates, available from public databases, are evaluated to determine their international prevalence and molecular characterization. These E. coli isolates have been disseminated in 12 countries across Asia and Europe. It was found that pigs and their products (n = 162) were the most common vehicle, followed by humans (n = 122), chickens (n = 60), and the environment (n = 49). Carbapenems-resistant genes blaNDM-5 (1.3%) and blaNDM-1 (0.2%) were identified, as well as colistin-resistant genes mcr-1.1 (12.6%) and mcr-3.1 (0.5%). It was noted that the tigecycline-resistant gene cluster tmexC-tmexD-toprJ1 was identified in seven (1.1%) isolates. Phylogenomic results indicated that tet(X4)-producing E. coli isolates fell into seven lineages (lineages I, II, III, IV, V, VI, and VII), and international spread mainly occurred in Asian countries, especially China, Pakistan, Singapore, and Malaysia. Four forms of tet(X4) transposon units were found, including the I-type (IS26-tet(X4)-ISCR2), II-type (ΔIS1R-tet(X4)-ISCR2), III-type (ISCR2-tet(X4)-ISCR2), and IV-type (ISCR2-tet(X4)-ΔISCR2). These findings underline further challenges for the spread of E. coli bearing tet(X4) gene.

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Zhu, Longkun, Vince Castranova, and Pingnian He. "fMLP-stimulated neutrophils increase endothelial [Ca2+]i and microvessel permeability in the absence of adhesion: role of reactive oxygen species." American Journal of Physiology-Heart and Circulatory Physiology 288, no. 3 (March 2005): H1331—H1338. http://dx.doi.org/10.1152/ajpheart.00802.2004.

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Our previous study demonstrated that firm attachment of leukocytes to microvessel walls does not necessarily increase microvessel permeability ( Am J Physiol Heart Circ Physiol 283: H2420–H2430, 2002). To further understand the mechanisms of the permeability increase associated with leukocyte accumulation during acute inflammation, we investigated the direct relation of reactive oxygen species (ROS) release during neutrophil respiratory burst to changes in microvessel permeability and endothelial intracellular Ca2+ concentration ([Ca2+]i) in intact microvessels. ROS release from activated neutrophils was quantified by measuring changes in chemiluminescence. When isolated rat neutrophils (2 × 106/ml) were exposed to formyl-Met-Leu-Phe-OH (fMLP, 10 μM), chemiluminescence transiently increased from 1.2 ± 0.2 × 104 to a peak value of 6.7 ± 1.0 × 104 cpm/min ( n = 12). Correlatively, perfusing individual microvessels with fMLP-stimulated neutrophils in suspension (2 × 107/ml) increased hydraulic conductivity ( Lp) to 3.7 ± 0.4 times the control value ( n = 5) and increased endothelial [Ca2+]i from 84 ± 7 nM to a mean peak value of 170 ± 7 nM. In contrast, perfusing vessels with fMLP alone did not affect basal Lp. Application of antioxidant agents, superoxide dismutase, vitamin C, or an iron chelator, deferoxamine mesylate, attenuated ROS release in fMLP-stimulated neutrophils and abolished increases in Lp. These results indicate that release of ROS from fMLP-stimulated neutrophils increases microvessel permeability and endothelial [Ca2+]i independently from leukocyte adhesion and the migration process.

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Josef Villafuerte, Conrad, Fred Gentili, David Shultz, Alejandro Berlin, Robert Heaton, Monique van Prooijen, Michael Cusimano, et al. "RADT-19. EFFECTS OF RADIATION DOSE-RATE AND TUMOR CHARACTERISTICS ON LOCAL CONTROL AND TOXICITY AFTER RADIOSURGERY FOR ACOUSTIC NEUROMAS." Neuro-Oncology 22, Supplement_2 (November 2020): ii185. http://dx.doi.org/10.1093/neuonc/noaa215.772.

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Abstract INTRODUCTION The effect of stereotactic radiosurgery (SRS) dose-rate on tumor control for acoustic neuroma (AN, or vestibular schwannoma) is unclear. METHODS This was a retrospective study of all patients treated for AN with frame-based cobalt-60 SRS at the Toronto Western Hospital between 2005-2019. Dose rates on the day of SRS were calculated from the calibration dose-rate while accounting for the cobalt-60 half-life of 5.2713 years. Local failure was defined as continued tumor growth >36 months post-SRS, tumor resection for LF, or use of any repeat SRS for LF. Cumulative incidence of LF was reported after accounting for competing risks of death, on a per-lesion basis. Comparisons of actuarial LF were made using Gray’s test. Multivariable analysis of LF was performed using a proportional hazards model. RESULTS A total of 607 patients were treated for 617 acoustic neuromas. Median follow-up was 5.0 years. 158 tumors (26%) were cystic. 71 tumors (12%) had previous resection. Nine patients received 10-11 Gy due to large tumor size; all remaining patients received 12 Gy to approximately the 50% isodose line. Median dose rate was 2.4 Gy/min (range, 1.3-3.7). There was no association between dose rate and LF (≥ 2.4 Gy/min vs. < 2.4 Gy/min, 6.07% vs. 6.12% at 5-year follow-up, p = 0.75). The adjusted local failure-specific hazard ratio (HR) for dose rate (per Gy/min) was 1.2 (95% CI 0.69-2.1, p = 0.52). Patients with previous surgery had higher LF, with a HR of 3.6 (95% CI 1.7-7.8, p = 0.0012), after adjusting for presence of cysts (HR 0.27, p = 0.034) and maximum tumor diameter (HR 1.055 per cm, p = 0.071). CONCLUSIONS In a large cohort of patients with acoustic neuromas, radiosurgery dose-rate was not associated with tumor control. Previous resection was a strong risk factor for local failure after SRS.

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Benaglia, P., C. H. Ishwara-Chandra, H. Intema, M. E. Colazo, and M. Gaikwad. "Cygnus survey with the Giant Metrewave Radio Telescope at 325 and 610 MHz: the catalog." Astronomy & Astrophysics 642 (October 2020): A136. http://dx.doi.org/10.1051/0004-6361/202037916.

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Context. Observations at the radio continuum band below the gigahertz band are key when the nature and properties of nonthermal sources are investigated because their radio radiation is strongest at these frequencies. The low radio frequency range is therefore the best to spot possible counterparts to very high-energy (VHE) sources: relativistic particles of the same population are likely to be involved in radio and high-energy radiation processes. Some of these counterparts to VHE sources can be stellar sources. Aims. The Cygnus region in the northern sky is one of the richest in this type of sources that are potential counterparts to VHE sources. We surveyed the central ∼15 sq deg of the Cygnus constellation at the 325 and 610 MHz bands with angular resolutions and sensitivities of 10″ and 6″, and 0.5 and 0.2 mJy beam−1, respectively. Methods. The data were collected during 172 h in 2013–2017, using the Giant Metrewave Radio Telescope with 32 MHz bandwidth, and were calibrated using the SPAM routines. The source extraction was carried out with the PyBDSF tool, followed by verification through visual inspection of every putative catalog candidate source in order to determine its reliability. Results. In this first paper we present the catalog of sources, consisting of 1048 sources at 325 MHz and 2796 sources at 610 MHz. By cross-matching the sources from both frequencies with the objects of the SIMBAD database, we found possible counterparts for 143 of them. Most of the sources from the 325-MHz catalog (993) were detected at the 610 MHz band, and their spectral index α was computed adopting S(ν) ∝ να. The maximum of the spectral index distribution is at α = −1, which is characteristic of nonthermal emitters and might indicate an extragalactic population.

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Benavides-Villanueva, F., C. Corrales-Selaya, I. Ferraz-Amaro, N. Vegas-Revenga, V. Portilla, R. Blanco, M. A. González-Gay, and A. Corrales. "POS0623 SUBCLINICAL ATHEROSCLEROSIS IS NOT RELATED WITH ACID URIC IN RHEUMATOID ARTHRITIS. STUDY OF 1005 PATIENTS OF A SINGLE UNIVERSITY HOSPITAL." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 579.2–580. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4005.

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BackgroundRheumatoid Arthritis (RA) and Gout are associated with an increase of cardiovascular (CV) disease (1,2). Carotid plaques and increased carotid intima-media thickness (cIMT) are surrogate markers of CV mortality (3). The association of serum uric acid (SUA) levels as an independent factor of subclinical Atherosclerosis and mortality in RA remains not fully clarified (4,5).ObjectivesIn a wide cohort of patients with RA our aims were to assess the relationship of SUA with a) CV risk factors and b) presence of atherosclerosis.MethodsCross-sectional study including 1005 patients with RA from a Single University Center. The presence of Atherosclerosis (c-IMT and carotid plaque) was explored by Carotid Ultrasonography. The relationship between SUA and markers of subclinical atherosclerosis was studied through linear regression and logistic multivariate analysis.ResultsWe studied 1005 RA patients (741 women, 74%), mean age 61±13. The main general features, CV risks factors, RA activity data and current therapy are summarized in Table 1.Table 1.Main features of 1005 RA patientsGENERAL FEATURESRESULTSGENERAL FEATURES (CONTINUATION)RESULTS (CONTINUATION) Age, years, mean±SD60±13RA features Female/ Male, n (%)741 (74) / 264 (26)RA duration, years; mean±SD17±12CRP, mg/L, median, [IQR]3.0 [0.9-7.5]CV risk factorsESR, mm/ 1st hour; median, [IQR]14 [6-24] Past or Current smoker, n (%)539 (54)Rheumatoid factor, n (%)528 (53) Obesity/ Dyslipidemia, n (%)307 (31)/ 560 (56)ACPA, n (%)492 (50) Hypertension, n (%)453 (45)DAS28-ESR; mean±SD3.3 ± 1.5 Diabetes Mellitus, n (%)127 (13)DAS28-CRP; mean±SD3.1 ± 1.3 BMI, kg/m2, mean±SD28±5/93±15Uric acid Abdominal circumference cm; mean±SDUric acid level (mg/dl); mean±SD4.8 ± 1.4 Previous CV Events, n (%)125 (12) Chronic Kidney Disease, n (%)58 (6)Carotid Ultrasonography Gout / using drugs for hyperuricemia; n (%)20 (2)cIMT microns; mean±SD708 ± 157 Total cholesterol, mg/dl; mean±SD201±39Carotid plaque¸ n (%)617 (62) HDL cholesterol, mg/dl; mean±SD61±17 LDL cholesterol, mg/dl; mean±SD119 ± 32Abbreviations: ACPA: Anti–citrullinated protein antibody; BMI: Body mass index; CV: Cardiovascular; cIMT: carotid intima-media thickness; cm: centimeter; CRP: C Reactive protein; DAS28-ESR: Disease Activity Score-28 for Rheumatoid Arthritis with Erythrocyte Sedimentation Rate; DAS28-PCR: Disease Activity Score-28 for Rheumatoid Arthritis with C reactive protein; dl: deciliter; ESR: Erythrocyte Sedimentation Rate; HDL: high-density lipoprotein; IQR: Interquartile range; Kg: kilogram; LDL: Low-density lipoprotein; mg: milligram; m2: square meter; n: number; RA: Rheumatoid Arthritis; SD: Standard Deviation.SUA as a dependent variable was significantly correlated with age, male gender and most of CV risk factors (body mass index, abdominal circumference and obesity) (single-variable analysis). Similarly, a significative beta coef. [95%CI] positive relationship with SUA was observed with hypertension (0.7 [0.5-0.8], p<0.001), diabetes (0.5 [0.2-0.7], p<0.001), dyslipidemia (0.2 [0.04-0.4], p=0.016), renal chronic insufficiency (1.5 [95CI 1.1-0.8], p<0.001) and previous CV events (0.8 [0.4-1.2], p<0.001).Subclinical Atherosclerosis, as dependent variable, was significantly correlated with SUA (single-variable analysis). In addition, SUA showed a positive significative beta coef. [95%CI] relationship with cIMT (18 [12-25], p<0.001) and the presence of carotid plaques (1.29 [17-1.42], p<0.001). However, statistical significance was not observed in the multivariable analysis adjusted by Classic CV Risk Factors.ConclusionIn RA, SUA is related with most of CV risk factors. However, SUA is not associated with Subclinical Atherosclerosis.References[1]Aviña-Zubieta JA, et al. Arthritis Rheum. 2008,15;59:1690-7.[2]Klein R, et al. Arch Intern Med 1973, 132:401–410.[3]de Groot E, et al. Circulation, 2004,109:33–38.[4]Lauren Shahin, et al Cureus 2021. 5; 13.:e14855.[5]Chiou A, et al. Arthritis Care Res (Hoboken). 2020, 72:950-958.Disclosure of InterestsNone declared

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Marincowitz, Carl, Omar Bouamra, Tim Coates, Dhushy Kumar, David Lockey, Virginia Newcombe, Lyndon Mason, David Yates, Julian Thompson, and Fiona Lecky. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (November 22, 2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics, injury mechanism, severity, treatment and outcomes of major trauma in England.Method and DesignDemographic characteristics and clinical pathways of TARN eligible patients in the first lockdown (24th March to 3rd July 2020 inclusive) and second lock down (1st November 2020 to 16th May 2021 inclusive) were compared to equivalent pre-COVID-19 periods in 2018–2019.A segmented regression model predicting the weekly risk adjusted survival was estimated and a discontinuity in the gradient (trend) or intercept (level) of the fitted model was tested for at the weekly time point of implementation of each lockdown.Abstract 1427 Figure 1Strobe diagram for inclusion of study populationAbstract 1427 Figure 2Interrupted time series analysis assessing the impact of COVID restrictions on likelihood of survival (red horizontal lines indicate introduction and relaxation of ‘lockdown’ measures)Abstract 1427 Table 1Comparison of demographics ‘lockdown’ and pre-COVID periodsPeriodPeriod24Mar19 – 03Jul19 (comparator)24Mar20 – 03Jul20 (lockdown 1)Absolute change [percentage point change (95%CI)] p-value01Nov18 – 16May19 (comparator)01Nov20 – 16May21 (lockdown 1)Absolute change [percentage point change (95%CI)] p-valueTotal2224317510-4733 (-21%)p<0.0001‡41016382622754 (–6.7%)p<0.0001‡Age (years), Median (IQR)67.6 (46.5–83.1)70.9 (50.3–84.2)3.3 (2.4 to 4.2)p<0.000169.1 (48.7–83.6)73.1 (53.3–85.1)4 (3.5 to 4.2)<0.0001Age bands, n(%)Age< 1138 (0.6%)130 (0.7%)-8 [0.1(-0.04 to 0.030)] p=0.14281 (0.7%)234 (0.6%)-47 [0.1 (-0.2 to 0.04)]p=0.1979Age <16942 (4.2%)674 (3.8%)-268 [-0.4 (-0.8 to 0]p=0.05311444 (3.5%)1218 (3.2%)-226 [-0.3(-0.6 to – 0.1)p=0.0084Age 16 – 649561 (43%)6974 (39.8%)-2587 [-3.2(-4.1 to -2.2)P<0.000117173 (41.9%)13980 (36.5%)-3193 [-5.3(-6 to -5)]p<0.0001Age 65 and over11740 (52.8%)9862 (56.3%)-1878 [3.5 (2.5 to 4.5)]p<0.000122399 (54.6%)23064 (60.3%)665 [5.7(5 to 6.3)]P<0.0001Age 85 and over4610 (20.7%)4047 (23.1%)-563 [2.4(1.6 to 3.2)]p<0.00018903 (21.7%)9731 (25.4%)828 [3.7 (3.1 to 4.3)]p<0.0001Male, n(%)12316 (55.4%)9512 (54.3%)-2804 [-1 (-2 to -0.6)]p=0.037322146 (54%)19769 (51.7%)-2377 [-2.3 (-3 to -1.6)]<0.0001CCI*, n(%)CCI 09359 (42.1%)6220 (35.5%)-3139 [ -6.5 (-7.5 to -5.6)] p<0.000116665 (40.6%)12806 (33.5%)-3859 [-7.1(-7.8 to -6.5)]p<0.0001CCI 1 – 58538 (38.4%)6896 (39.4%)-1642 [1 (0.3 to 2)]p=0.042615899 (38.8%)15667 (40.9%)-232 [2.2 (1.5 to 2.9)]p<0.0001CCI 6 – 103032 (13.6%)3061 (17.5%)29 [3.8 (3.2 to 4.6)]p<0.00015987 (14.6%)6863 (17.9%)876 [3.3(2.8 to 3.8)]p<0.0001CCI > 10927 (4.2%)1024 (5.8%)97 [1.7(1.2 to 2.1)]p<0.00011648 (4%)2410 (6.3%)762 [2.3(2 to 2.6)]p<0.0001Not recorded387 (1.7%)309 (1.8%)-88 [0.2 (-0.2 to 0.3)]p=0.8513817 (2%)516 (1.3%)-301 [-0.6(-0.8 to -0.5)]p<0.0001MOI**: RTC, n(%)Car occupant1247 (30.7%)551 (20.4%)-696 [-10.4(-12.4 to -8.2)]p<0.00012485 (35.2%)1551 (31.3%)-934 [-3.9(-5.6 to -2.2)]p<0.0001Pedestrian661 (16.3%)288 (10.6%)-373 [-5.6 (-7.2 to -4)]p<0.00011629 (23.1%)962 (19.4%)-667 [-3.7(-5.1 to -2.2)]p<0.0001Motorcycles1196 (29.4%)711 (26.3%)-485 [-3.2(-5.3 to -1)]p<0.00011524 (21.6%)976 (19.7%)-548[ -1.9(-3.3 to -0.4)]p<0.0001Cyclist912 (22.4%)1139 (42.1%)227 [19.6(17.4 to 21.9)]p<0.00011315 (18.6%)1396 (28.2%)81 [9.5(8 to 11.1)]p<0.0001Other11 (0.3%)<9 ()-10 [ -0.2(-0.4 to -0.06)p=0.025131 (0.4%)10 (0.2%)-21 [-0.23(-0.4 to -0.04)]p=0.0281MOI: Intentional, n(%)Intentional assault130 (0.6%)88 (0.5%)-42 [-0.08 (-0.2 to 0.06)]p=0.2724227 (0.6%)175 (0.5%)-52 [-0.1(-0.2 to 0.002)]P=0.0570Self harm276 (1.2%)284 (1.6%)8 [0.4 (0.1 to 0.6)]p=0.0014525 (1.3%)562 (1.5%)37 [0.2 (0.02 to 0.3)]p=0.0223NAI63 (0.3%)27 (0.2%)-36 [-0.1(-0.2 to -0.03)]p=0.007297 (0.2%)90 (0.2%)-7 [-0.001(-0.07 to 0.07)]p=0.9701Shooting34 (0.2%)40 (0.2%)6 [0.08(-0.01 to 0.2)]p=0.082680 (0.2%)56 (0.1%)-24 [ -0.05(-0.1 to 0.001)]p=0.0979Stabbing450 (2%)312 (1.8%)-138 [-0.2(-0.5 to 0.03)]p=0.0816791 (1.9%)589 (1.5%)-202 [-0.4 (-0.6 to -0.2)]p<0.0001Blows1174 (5.3%)647 (3.7%)-527 [-1.6(-1.9 to -1.2)]p<0.00012059 (5%)1299 (3.4%)-760 [-1.6(-1.9 to -1.3)]p<0.0001Unintentional, n(%)Falls>2m2055 (9.2%)1757 (10%)-298 [0.8(0.2 to 1.4)]P=0.00753740 (9,1%)3528 (9.2%)-212 [0.1(-0.3 to 0.5)]p=0.6181Falls<2m13384 (60.2%)11314 (64.6%)-2070 [4.4 (3.5 to 5.4)]p<0.000125505 (62.2%)26203 (65.8%)698 [6.3 (5.6 to 6.9)]p<0.0001Sport449 (2%)320 (1.8%)-129 [-0.2 (-0.5 to 0.01]p=0.1697615 (1.5%)489 (1.3%)-126 [-0.2 (-0.4 to -0.006)]p=0.0079GCS bands , n(%)Mild19609 (88.2%)15449 (88.2%)4160 [0.1 (-0.6 to 0.7)]p=0.826435831 (87.4%)34051 (89%)-1780 [1.6 (1.2 to 2.1)]p<0.0001Moderate689 (3.1%)625 (3.6%)-64 [0.5(0.1 to 0.8)]p=0.00901333 (3.2%)1127 (2.9%)-206 [-0.3 (-0.5 to -0.06)]p=0.0135Severe955 (4.3%)765 (4.4%)-190 [0.1 (-0.3 to 0.5)]p=0.71361886 (4.6%)1464 (3.8%)-422 [-0.8(-1 to -0.5)]p<0.0001Not recorded990 (4.5%)671 (3.8%)-319 [ -0.6(-1 to -0.2)]p=0.00221966 (4.8%)1620 (4.2%)-346 [-0.6(-0.8 to -0.3)]p=0.0002ISS***, median (IQR)9 (9–18)9 (9–18)09 (9–18)9 (9–17)0ISS bands, n(%)ISS 1 – 84545 (20.4%)3062 (17.5%)-1483 [-3 (-4 to -2)]p=<0.00018266 (20.2%)7838 (20.5%)-428 [0.3(-0.2 to 0.9)]p=0.2457ISS 9 – 159290 (41.8%)7728 (44.1%)-1562 [2.4(1.4 to 3.3)]p<0.000117207 (42%)16969 (44.3%)-233 [2.4(1.7 to 3.1)]p<0.0001ISS >158408 (37.8%)6720 (38.4%)-1688 [5.6(-0.4 to 1.5)]p=0.239115543 (37.9%)13455 (35.2%)-2088 [-2.7 (-3.4 to -2)]p<0.0001ISS >253995 (18%)3127 (17.9%)-868 [-0.1(-0.9 to 0.7 )]p=0.79217521 (18.3%)6201 (16.2%)-1320 [-2.1(-2.6 to -1.6)]p<0.0001Body regions, n(%)Head AIS 3+5911 (26.6%)4670 (26.7%)-1241 [0.1 (-0.8 to 1)]p=0.830111128 (27.1%)9629 (25.2%)-1499 [ -2(-2.6 to -1.3)]p<0.0001Face AIS 3+63 (0.3%)41 (0.2%)-22 [-0.05 (-0.1 to 0.05)]p=0.341699 (0.2%)69 (0.2%)-30 [-0.06 (-0.1 to 0)]p=0.0618Chest AIS 3+4787 (21.5%)3915 (22.4%)-872 [8.3 (0.2 to 1.6)]<0.04508515 (20.8%)8075 (21.1%)-440 [0.3 (-0.2 to 0.9)]p=0.2337Abdomen AIS 3+872 (3.9%)690 (3.9%)-182 [0.02 (-0.3 to 0.4)]p=0.91771465 (3.6%)1179 (3.1%)-286 [-0.5 (-0.7 to -0.2)]p=0.0001Spine AIS 3+1985 (8.9%)1561 (8.9%)-424 [-0.01(-0.6 to 0.5)]p=0.97443784 (9.2%)3459 (9%)-325 [-0.2(-0.6 to 0.2)]p=0.3654Pelvis AIS 3+758 (3.4%)600 (3.4%)-158 [0.02(-0.3 to 0.4)]p=0.91841501 (3.7%)1386 (3.6%)-115 [-0.04(-0.3 to 0.2)]p=0.7802Limb AIS 3+5707 (25.7%)4892 (27.9%)-815 [2.3 (1.4 to 3.2)]p<0.000110719 (26.1%)10122 (26.5%)-597 [0.3(-0.3 to 0.9)]p=0.3053Other AIS 3+217 (1%)199 (1.1%)-18 [0.2 (-0.04 to 0.3)]p=0.1176375 (0.9%)396 (1%)21 [0.1 (-0.01 to 0.2]p=0.0836Polytrauma1622 (7.3%)1350 (7.7%)-272 [0.4 (-0.1 to 0.9)]p=0.11602984 (7.3%)2429 (6.3%)-555 [-0.9(-1.2 to 0.6)]p<0.0001*CCI Charlson Comorbidity Index**MOI Mechanism of injury***ISS Injury Severity Score‡chi square test for uniform distributionAbstract 1427 Table 2Comparison care pathways ‘lockdown’ and pre-COVID periodsPeriodPeriod24Mar19 – 03Jul19 (comparator)24Mar20 – 03Jul20 (lockdown 1)Absolute Change01Nov18 – 16May19 (comparator)01Nov20 – 16May21 (lockdown 2)Absolute Change1stHospital MTC9908 (44.5%)7376 (42.1%)-2532 [-2.4 (-3.4 to -1.4)]p<0.000118099 (44.1%)15928 (41.6%)-2171 [-2.5 (-3.2 to -1.8)]p<0.0001Treated at MTC11176 (50.2%)8256 (47.2%)-2920 [-3 (-4 to -2)]p<0.000120395 (49.7%)17852 (46.7%)-2543[-3 (-4 to -2.4)]p<0.0001Consultant ED8140 (36.6%)5562 (31.8%)-2578 [-4.8(-5.8 to -3.9)]p<0.000114779 (36%)12577 (32.9%)-2202 [-3.2 (-3.8 to -2.5)]p<0.0001CT within 1 hr5062 (31.9%)3992 (30.9%)-1070 [-0.9(-2 to 0.1)]p=0.09449203 (31.6%)7776 (27.1%)-1427 [-4(-5 to -3.7)]p<0.0001Whole body CT3348 (15.1%)3210 (18.3%)-138 [3 (2 to 4)]p<0.00016040 (14.7%)6417 (16.8%)377 [2 (1.5 to 2.5)]p<0.0001ICU stay3092 (13.9%)2208 (12.6%)-884 [-1.3(-1.9 to -0.6) ]p=0.00025591 (13.6%)3850 (10.1%)-1741 [-3.6(-4 to -3)]p<0.0001Mortality*1417 (7.1%)1316 (8.3%)-101 [1.2 (0.6 to 1.7)]p<0.00012916 (7.9%)2858 (8.1%)-58 [0.2 (-0.1 to 0.6)] p=0.2040Discharge destination, n(%)Home (own)13800 (62%)10484 (59.9%)-3316 [-2(-3.1 to -1.2)]p<0.000124961 (60.9%)23368 (61.1%)-1593 [-0.7 (-1.4 to -0.05)]p=0.0340Home (relative/carer)473 (2.1%)372 (2.1%)-101 [0 (-0.3 to 0.3)]p=0.9890974 (2.4%)852 (2.2%)-122 [-0.1(-0.4 to 0.06)]p=0.1653Mortuary*1501 (6.7%)1323 (7.6%)-178 [0.8(0.3 to 1.3)]p=0.00193086 (7.5%)2977 (7.8%)-109 [0.1 (-0.3 to 0.5)]p=0.5113No fixed abode75 (0.3%)47 (0.3%)-28 (-37.3%)107 (0.3%)87 (0.2%)-20 (-18.7%)Not Known87 (0.4%)39 (0.2%)-48 (-55.2%)101 (0.2%)95 (0.2%)-6 (-5.9%)Nursing Home1190 (5.3%)1063 (6.1%)-127 [0.7(0.3 to 1.2)]p=0.00202448 (6%)2231 (5.8%)-217 [-0.2(-0.6 to 0.1)]p=0.1620Other Acute hospital2425 (10.9%)1736 (9.9%)-689 [-0.1(-1.6 to -0.4)]p=0.00144346 (10.6%)3313 (8.7%)-1033 [-0.1(-0.5 to 0.2)]p=0.4115Other institution526 (2.4%)516 (2.9%)-10 [0.6 (0.3 to 0.9)]p=0.0003980 (2.4%)870 (2.3%)-110 [-0.1 (-0.3 to 0.1)]p=0.2817Rehabilitation2077 (9.3%)1871 (10.7%)-206 [1.3(0.7 to 1.9)]p<0.00013851 (9.4%)4274 (11.2%)423 [ 1.7(1.3 to 2.2)]p<0.0001Social care63 (0.3%)50 (0.3%)-13 [0 (-0.1 to 0.1)]p=0.9657121 (0.3%)103 (0.3%)-18 [-0.2(-0.1 to 0.5)]p=0.4939*These totals do not correspond as mortality includes deaths in the community and is censored at 30 daysResults and ConclusionThe first ‘lockdown’ had a larger associated reduction in total trauma volume (-21%) compared to the pre-COVID period than the second ‘lockdown’ (-6.7%). Trauma volume increased for those 65 and over (3%) and 85 and over (9.3%) during the second ‘lockdown’.There was a reduction in likelihood of survival (-1.71; 95% CI:-2.76 to -0.66) associated with the immediate introduction of the first ‘lockdown’. However, this was followed by a trend of improving survival (0.25; 95% CI: 0.14 to 0.35) and likelihood of survival returned to pre-pandemic levels by the end of the first ‘lockdown’ period.Future research is needed understand the initial reduction in likelihood of survival after major trauma observed with the implementation of the first ‘lockdown’ to prevent this occurring if measures re-introduced.

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Mehta, P., T. Skaria, M. Pai, G. B, A. Baby, S. Shan, A. Vijayan, S. Ahmed, and P. Shenoy. "AB1460 CHARACTERISTICS AND EARLY OUTCOMES OF PALINDROMIC RHEUMATISM: AN INCEPTION COHORT FROM INDIA." Annals of the Rheumatic Diseases 82, Suppl 1 (May 30, 2023): 1958.1–1958. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3719.

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BackgroundThe exact pathogenesis and risk factors of Palindromic Rheumatism (PR) remain uncertain, however, a subgroup of patients with PR share a close relationship with rheumatoid arthritis (RA) in terms of etiopathogenesis, clinical features, serology, and outcomes.ObjectivesWe aim to describe the characteristics of patients in an inception cohort of PR along with determinants of progression to RA.MethodsPatients with symptoms suggestive of PR were screened by a rheumatologist and after relevant exclusions, were classified into PR and included in an inception cohort at the Centre for Arthritis and Rheumatism Excellence, India. Their demographics, clinical characteristics, serology, inflammatory markers, and progression to RA or any other autoimmune rheumatic disease(AIRD) were recorded. Statistical analysis was done using GraphPad Prism v9.4.1 and results are expressed as mean ± standard deviation.ResultsOf 706 patients screened, 685 were classified into PR (age 45.5±11.9 and male-to-female ratio of 1:2.8) with a follow-up duration of 27±20.4 months. Of those with a follow-up of greater than one year, 102 of 505 (20.2%) progressed to RA at 30± 20 months and 13 to other AIRDs.Progression to RA was positively associated with a greater number of attacks per month; severe PR or >20 attacks per month; shoulder or wrist joint involvement, absence of erythema, positive rheumatoid factor, anti-CCP antibody, and ANA on univariate analysis. Additionally, they required treatment with a higher number of cDMARDs and even anti-TNFs (Table 1). On multivariate analysis, symptom duration of <5 years, wrist involvement, and anti-CCP positivity were associated with progression to RA. The RF and anti- CCP titers showed no association with progression to RA.ConclusionEarly outcomes of the inception cohort of PR revealed progression to RA in 20% of the cohort and was associated with symptom duration of <5 years, wrist involvement, and anti-CCP positivity. The PR group was treated predominantly with colchicine and cDMARDs with a remission rate of 60%.Table 1.Comparison of clinical presentation and treatment between persistent PR and Evolved RAVariablePersistent PR N=403Evolved to RA N=102Univariate#;p value, OR(95%CI)Multivariate##;P value, HR(95%CI)Age, years46± 1247± 110.4Sex, female303(24.8)78(23.5)0.9Disease Duration > 5 years186(46.1)36(16.2)0.060.01, 0.6(0.3-0.8)Follow up, months34 ± 1934± 160.7Number of attacks per month8.5± 9.111 ± 110.01Pain VAS8.3 ± 1.98.1± 1.90.6Duration of attack, days2.8± 1.62.9 ± 1.80.4Severe PR *49 (12.2)24 (23.5)0.004, 2.2(1.3-3.8)0.5Joint Involvement0.5DIP220 (54.6)63 (61.7)0.1160.04, 2.5(1.1-5)MCP/PIP365 (90.6)90 (89.2)0.294Shoulder326 (80.9)92 (90.2)0.015, 2.8 (1.1-4.3)Wrist325 (80.6)93 (91.2)0.006, 2.4 (1.2-5.1)Lower Limb joints377 (93.5)99 (97.1)0.382Presence of erythema242 (60.0)42 (41.2)<0.001, 0.4(0.2-0.7)0.1Smoking6(5.8)7(1.7)0.03, 0.3(0.1-0.8)0.08Baseline ESR, mm24 ± 2028 ± 220.090.6RF positivity195 (48.4)70 (68.6)<0.001, 2.3(1.5-3.7)0.2Anti-CCP positivity245 (60.8)87 (85.3)<0.00, 3.7(2.1-6.7)0.01, 2.8(1.4-6.2)ANA positive82 (40.4)32 (31.4)0.014, 1.8(1.1-2.9)0.5TreatmentHCQ24(5.9)1(0.98)0.01, 0.2(0.02-0.8)Colchicine3(0.74)00.9HCQ +Colchicine139(34.4)25(24.5)0.06Colchicine + 2 cDMARDs194(48)65(63.7)0.01, 1.9(1.2-2.9)Colchicine + 3 cDMARDs17 (4.2)41 (40.2)<0.01, 15.3(8.2-28.5)Steroids176(43.7)50(49.0)0.206Rituximab27(6.7)9(88.2)0.289Anti TNF02(1.9)0.04Tofacitinib4(9.9)00.563Remission**242(60.0)58(56.8)0.317#p value <0.05 by Chi square or unpaired t test ## cox proportional hazards test*Severe PR: attacks >20/month**Remission: asymptomatic for one month at last follow upTNF-Tumour Necrosis Factor, OR- Odds Ratio, HR- Hazards ratio, HCQ- Hydroxychloroquine, cDMARDS- Conventional Disease Modifying Anti Rheumatoid Drugs, IP- Interphalangeal Joint, P- Proximal, D- Distal, MCP- Metacarpophalangeal Joint, RF- Rheumatoid Factor, RA- Rheumatoid ArthritisREFERENCES:NIL.Acknowledgements:NIL.Disclosure of InterestsNone Declared.

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Bouzabata, Amel, Faffani Boussaha, Joseph Casanova, and Félix Tomi. "Composition and Chemical Variability of Leaf Oil of Myrtus Communis from North-Eastern Algeria." Natural Product Communications 5, no. 10 (October 2010): 1934578X1000501. http://dx.doi.org/10.1177/1934578x1000501029.

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The chemical composition of 27 oil samples of Myrtus communis isolated from leaves collected in three locations in north–eastern Algeria was investigated by GC(RI) and 13C NMR spectroscopy. Yields ranged between 0.2-1.2% (w/w). The chemical composition of the oils was largely dominated by monoterpene hydrocarbons, with α-pinene (40.5-64.0%), 1,8-cineole (10.9-29.1%) and limonene (6.7-8.2%) being the major compounds. In all the samples, 3,3,5,5,8,8-hexamethyl-7-oxabicyclo[4.3.0]non-1(6)-ene-2,4-dione was identified (0.8-1.5%). The composition is similar to that reported for myrtle oils from Corsica, Sardinia and Tunisia, but differed from that of Moroccan and Spanish myrtle oils.

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Lv, Jun-lan, Rui-sheng Li, Shi-ying Jin, Hai-long Yuan, Shan-shan Fu, Jin Han, Shi-xiao Jin, and Xiao-he Xiao. "Changes of pharmacokinetics of 6,7-dimethoxycoumarin in a rat model of alpha-naphthylisothiocyanate-induced experimental hepatic injury after Yinchenhao Decoction (茵陈蒿汤) treatment." Chinese Journal of Integrative Medicine 18, no. 11 (October 20, 2012): 831–36. http://dx.doi.org/10.1007/s11655-012-1272-8.

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L. G., Hassan, Kabiru J. Umar, and Yuguda H. "Nutrition Evaluation of Faidherbia albida Seeds and Pulp as Source of Feeds for Livestock." African Journal of Food, Agriculture, Nutrition and Development 7, no. 16 (September 19, 2007): 01–11. http://dx.doi.org/10.18697/ajfand.16.1835.

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The present study was conducted to find out the nutritional values of Faidherbia albida (Acacia albida) seeds and pulp to be used as components in livestock feeds. The samples were randomly collected from various trees during the period of January to February. The samples were separated, milled and analysed for proximate components and mineral elements using standard methods of the AOAC. Proximate analysis results showed that the concentrations of tested parameters in the seed and the pulp respectively on % dry matter were: dry matter (90.0 + 0.4; 93.3 + 0.2), ash (3.3 + 0.1; 6.7 + 0.1), crude protein (20.6 + 1.2; 19.5 + 0.4), crude lipid (13.3 + 0.1; 3.3 + 0.1), crude fibre (6.7 + 0.1; 13.3 + 0.2), and available carbohydrate (46.1 + 0.1; 50.53 + 0.7). The results indicated that the contents of dry matter, ash, crude fibre and available carbohydrate were significantly higher (p < 0.05) in the pulp compared to the seed while the crude lipid values, however, were significantly higher (p < 0.05) in seeds compared to pulp. Crude protein values did not differ significantly (p > 0.05) between treatment means of seeds and pulp. The estimated energy value was significantly higher (p < 0.05) in the seed (1,682 kJ/100g) compared to pulp (1,363kJ/100g). The results for the mineral analysis indicate that the seeds and pulp contain appreciable concentrations (mg/100g) of Ca (136.6 + 5.0; 55.0 + 5.0); Mg (135.0 + 2.0 + 5.0; 84.7 + 3.0); P (26.6 + 0.9; 29.6 + 0.7); K (144.5 + 0.2; 88.8 + 0.1); Na (12.5 + 0.1; 6.8 + 0.1); Fe (6.2 + 0.2; 8.8 + 0.3); Cu (5.8 + 0.1; 2.5 + 0.1) and Zn (8.0 + 0.1; 3.0 + 0.1). Mineral elements in seed are significantly higher (p < 0.05) compared to that of pulp in most cases. From the results it can be inferred that the seed and pulp of F. albida could be an important source of feed ingredient for livestock if properly harnessed.

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Ivanchenko, A. V., V. A. Basharin, I. S. Drachev, A. B. Seleznev, and A. Yu Bushmanov. "To the Question About Pharmacological Protection During Irradiation In Non-infecting Doses: Maybe, Necessary? Communication 2. Review of Pathogenetic Aspects and Methods for Assessing the Efficiency of Anti-Radiation Agents in Experiment." MEDICAL RADIOLOGY AND RADIATION SAFETY 67, no. 4 (August 2022): 101–12. http://dx.doi.org/10.33266/1024-6177-2022-67-4-101-112.

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Purpose: Review and systematization of modern ideas about the mechanisms of the development of the effects of ionizing radiation in medium doses on a living organism in order to assess the need and possibility of using pharmaceutical agents suitable for modification purposes, about research methods in experiment; stimulation of discussion on the issue under consideration. Results: the current understanding of the genesis of radiation effects from irradiation at medium doses in the range of 0.2-1 Gy as a subject of modification with antiradiation agents is considered. Conclusions: The systematic nature of modern knowledge about the genesis of radiation effects from low-power irradiation in medium doses of the range 0.2-1 Gy, heterogeneity and mixing of mechanisms can be considered as a basis for the use of antiradiation agents with different properties and aimed at target (direct) and non-target (indirect) ) the effect of radiation. One of the problems of using and predicting the radioprotective efficiency of the PLC is the poor development of methods for establishing correlations between the indicators of increased radioresistance (without irradiation) with the actual antiradiation effect.

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Krishna, Varna, Vijay K. Shankar, Lakshmidevamma Madarakallu Muniyappa, and Mahagundappa M. Benal. "Prediction of Temperature During Machinability of Al2O3 Reinforced Al7075." Revue des composites et des matériaux avancés 30, no. 5-6 (December 30, 2020): 241–46. http://dx.doi.org/10.18280/rcma.305-607.

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Metal matrix composite Al2O3 particle reinforced Al have become useful engineering materials due to their properties such as low cost, wear-resistant, heat-resistant and low weight. The present study focused on prediction of temperature produced during machining of Al2O3 reinforced with Al7075. In this investigation the percentage of Al2O3 (mesh size of 100-300)was varied 1%, 3%, 5%, 7% and 9% to the base material of Al7075. The temperature was measured using thermal gun at machining tip of the tool at which maximum temperature were measured by varying operational parameters such as depth of cut (0.25, 0.5, 0.75, 1 and 1.25mm), spindle speed (80, 112, 140, 200 and 355rpm) and feed rate (0.10, 0.12, 0.16, 0.2 and 0.25mm/sec). Experimental results revels that the temperature increases with increase in feed rate and depth, whereas, in case of spindle speed there is a fluctuation in temperature for all the combinations considered. The percentage contribution of operational parameters on temperature was determined using ANOVA analysis. Overall analyses for all the combination considered shows that feed rate (45.07%), depth (33.75%) and spindle speed (5.2%) on temperature. The developed models with a P-value are less than 0.05 were considered to be a statistically significant with 95% of confidence interval. A good agreement between experimental and statistical modeling were achieved and comparison of experimental and statistical analysis were drawn.

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Sluiter, Justin B., Helena Chum, Absai C. Gomes, Renata P. A. Tavares, Vinicius Azevedo, Maria T. B. Pimenta, Sarita C. Rabelo, et al. "Evaluation of Brazilian Sugarcane Bagasse Characterization: An Interlaboratory Comparison Study." Journal of AOAC INTERNATIONAL 99, no. 3 (May 1, 2016): 579–85. http://dx.doi.org/10.5740/jaoacint.15-0063.

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Abstract This paper describes a study of the variability of measured composition for a single bulk sugarcane bagasse conducted across eight laboratories using similar analytical methods, with the purpose of determining the expected variation for compositional analysis performed by different laboratories. The results show good agreement of measured composition within a single laboratory, but greater variability when results are compared among laboratories. These interlaboratory variabilities do not seem to be associated with a specific method or technique or any single piece of instrumentation. The summary censored statistics provide mean values and pooled standard deviations as follows: total extractives 6.7% (0.6%), whole ash 1.5% (0.2%), glucan 42.3% (1.2%), xylan 22.3% (0.5%), total lignin 21.3% (0.4%), and total mass closure 99.4% (2.9%).

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Bai, Xue, Alexander Noor Shoushtari, Allison Betof Warner, Henry Quach, Christopher G. Cann, Michael Zhang, Lalit Pallan, et al. "Discrepancies in response and immune-related adverse events (irAE) of anti-PD-1 monotherapy between races and primary sites in patients (pts) with advanced nonacral cutaneous melanoma (NACM)." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): 9530. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.9530.

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9530 Background: Ultraviolet (UV)-induced high tumor mutation burden (TMB) of NACM is associated with response to anti-PD-1 monotherapy (aPD-1). Anatomic location of the primary lesion (reflecting UV exposure) and race (reflecting eumelanin level) may serve as surrogates for TMB and be associated with varying response and irAE patterns. Methods: Pts with advanced NACM receiving aPD-1 between 2009-2019 were retrospectively analyzed from 5 institutions in the US, Australia and China. Best response, survival (PFS and OS), and organ/system-specific irAEs were compared by race (Caucasian [C] vs non-Caucasian [NC]) and primary anatomic site. Results: Among 697 patients, 616 were C, 81 were NC. Complete response rate (CRR) was 24.8% (95%CI, 21.4-28.4) and 2.6% (95%CI, 0.3-9.1) and ORR was 54.9% (95%CI, 50.9-58.9) and 15.6% (95%CI, 8.3-25.6) in C and NC, respectively (both P<.001). Median PFS was 16.5 (95%CI, 12.0-23.1) and 5.2 (95%CI, 3.6-7.6) months, median OS was 60.5 (95%CI, 49.9-not reached [NR]) and 29.2 (95%CI, 17.9-NR) months, in C and NC, respectively (P<.001 and =.04). In multivariate analyses, C had significantly higher CRR (OR 13.4, 95%CI 3.1-57.4), ORR (OR 10.6, 95%CI 4.6-24.5), and longer PFS (HR 0.5, 95%CI 0.4-0.7) than NC. Compared to a head primary site, NACM from less UV-exposed regions had significantly lower CRR (upper trunk, OR 0.6, 95%CI 0.4-0.96; lower limb, OR 0.5, 95%CI 0.2-0.9), ORR (lower limb, OR 0.6, 95%CI 0.3-0.9) and poorer PFS (perineum/buttock, HR 2.1, 95%CI 1.2-3.5; lower limb, HR 1.6, 95%CI 1.2-2.2) and OS (perineum/buttock, HR 3.8, 95%CI 2.2-6.8; lower limb, HR 1.7, 95%CI 1.2-2.4). Overall irAE incidence was similar between C and NC but irAE subtypes varied. C had significantly higher incidence of GI (12.2%, 95%CI 9.5-15.3% vs 1.2%, 95%CI, 0.03-6.7%, P=.001), respiratory (10.3%, 95%CI 7.8-13.2% vs 0, P<.001) and grade 3/4 (15.4%, 95%CI 12.4-18.8% vs 6.2%, 95%CI 2.0-13.8%, P=.03) irAEs; and lower incidence of endocrine (13.8%, 95%CI 10.9-17.0% vs 32.1%, 95%CI 22.2-43.4%, P<.001) and liver (4.8%, 95%CI 3.2-7.1% vs 13.6%, 95%CI, 7.0-23.0%, P=.005) irAEs. IrAEs did not vary by primary NACM site. Conclusions: Race and primary site are independently correlated with distinct response and survival outcomes in pts with advanced NACM receiving aPD-1. IrAE subtypes vary by race although overall irAE incidence does not.

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Cabrera-Villalba, S., G. Avila, A. Amarilla, M. Zarza, E. Leiva, P. Pusineri, L. Roman, V. Valinotti, and P. DE Abreu Trigueros. "AB1364 VACCINATION AGAINST COVID-19 IN PARAGUAYAN PATIENTS WITH RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (May 30, 2023): 1912.1–1912. http://dx.doi.org/10.1136/annrheumdis-2023-eular.6094.

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BackgroundIn February 2021, the first doses of COVID-19 vaccines were received in Paraguay, and rheumatic patients were the preferred population to get these vaccines. Up to December 2022 the vaccination coverage in Paraguay was 59.4%, with at least one vaccine dose. 52.4% accessed the primary scheme (two doses), while 28.6% had at least one booster dose. Only 7.1% completed the COVID-19 immunization scheme.ObjectivesTo describe vaccination against COVID-19 in Paraguayan patients with Rheumatoid Arthritis (RA).MethodsDescriptive, cross sectional, observational study, in a Paraguayan cohort of RA patients meeting ACR/EULAR2010 criteria, under follow-up in two Rheumatology reference centers, from October to December 2022. A standardized questionnaire according to the variables included (clinical, vaccination, vaccine type, number of doses) was made. Quantitative variables were presented as means and qualitative as frequencies.Results568 patients with RA were included, 84.1% were female, mean age 55.48±13.94 years old. 23.9% patients were from Hospital de Clínicas and 76.1% from Hospital Central del Instituto de Previsión Social. The average number of received vaccinations doses was 2.54±1.19. 88.7% of patients acquired at least one dose of COVID-19 vaccine, 85% obtained two doses; and, while 60.9% of patients received the first booster, 21.2% had the second one.ConclusionIn this series of Paraguayan RA patients, vaccination against COVID-19 is higher than the general population, perhaps due to priority of patients with rheumatic diseases receiving immunization, and frequent access to medical care with physician’s prompt to receive vaccinations. While over 80% of patients have a complete primary schedule, and more than 60% received the first booster; only 21% have a complete immunization schedule, which is still much higher than the general population in Paraguay.Table 1.Vaccines in Paraguayan patients with Reumatoid ArthritisVaccines against COVID-19First Dosen: 504Second Dosen: 483First boostern: 344Second boostern: 122Sputnik V(Gam--COVID-Vac) n (%)149 (26.2)137 (24.1)10 (1.8)0Astrazeneca (ChAdOx1 nCoV-19) n (%)172 (30.3)171 (30.1)110 (19.4)36 (29.5)Pfizer n (BNT162b2) (%)81 (14.3)80 (14.1)198 (34.9)68 (55.7)Moderna (mRNA-1273) n (%)41 (7.2)38 (6.7)22 (3.9)18 (14.8)Hayat Vax n (%)29 (5.1)28 (4.9)1 (0.2)0Sinopharm BBIBP n (%)2 (0.4)1 (0.2)00Covaxin n (%)28 (4.9)26 (4.6)3 (0.5)0CoronaVac n (%)2 (0.4)2 (0.4)00REFERENCES:NIL.Acknowledgements:NIL.Disclosure of InterestsNone Declared.

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Driscoll, Sarah, Gideon Meyerowitz-Katz, Golo Ahlenstiel, Tahlia Reynolds, Kate Reid, and Ramy H. Bishay. "Efficacy of Telephone Health Coaching Integration with Standard Multidisciplinary Care for Adults with Obesity Attending a Weight Management Service: A Pilot Study." Nutrients 13, no. 11 (November 15, 2021): 4078. http://dx.doi.org/10.3390/nu13114078.

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Australia has one of the highest prevalences of obesity in the developed world with recognised gaps in patient access to obesity services. This non-randomised before and after study investigated the health benefits and patient acceptability of integrating the Get Healthy Service, a state-funded telephone-delivered coaching service in Australia, as an adjunct to multidisciplinary care for adults attending a public obesity service. Forty-one participants received multidisciplinary care alone while 39 participants were subsequently allocated to receive adjunctive treatment with the Get Healthy Service. Weight, body mass index, glycosylated haemoglobin, measurement of hepatic steatosis and liver enzymes were collected at baseline and 6 months. Participant evaluation was obtained post intervention. Statistically significant reductions from baseline were achieved for both control and intervention with respect to weight (−6.7 ± 2.2 kg, p = 0.01; −12.6 ± 3.2, p = 0.002), body mass index (−2.3 ± 0.8, p = 0.01; −4.8 ± 1.2 kg/m2, p = 0.002) and glycosylated haemoglobin (−0.2 ± 0.2%, p = 0.2 (NS); −0.7 ± 0.2%, p = 0.02), respectively. There were no significant differences in steatosis or liver enzymes or in outcomes between control and intervention cohorts. A high level of patient acceptability was reported. Integrating telephone-delivered coaching provided non-inferior care and high levels of patient satisfaction. Telephone coaching aligned with the principles of an obesity service should be trialled to improve patient access to obesity interventions.

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Hao, Weihao, Jiahua Xu, Feiyu Zhao, Dong-Wook Sohn, and Xuepeng Shi. "Integration of Photovoltaic Shading Device and Vertical Farming on School Buildings to Improving Indoor Daylight, Thermal Comfort and Energy Performance in Three Different Cities in China." Buildings 14, no. 11 (October 31, 2024): 3502. http://dx.doi.org/10.3390/buildings14113502.

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This study explores the integration of photovoltaic (PV) shading devices and vertical farming (VF) in school buildings to optimize indoor daylight, thermal comfort, and energy performance across three different climate regions in China: Beijing, Shanghai, and Shenzhen. With rapid urbanization and increasing energy consumption in educational buildings, this research investigates the impact of innovative facade design on both energy efficiency and occupant comfort. Through parametric simulations and multi-objective optimization, various PV and VF facade prototypes were evaluated to determine the best configurations for reducing energy consumption while enhancing thermal and visual comfort. This study optimized facade systems integrating photovoltaic and vertical farming for school buildings in Shenzhen, Beijing, and Shanghai. Key findings include: In Shenzhen, Model B’s UDI increased by 5.1% and Model C by 19.02%, with glare areas reduced by 5.4% and 21.40% and stable thermal comfort (PMV 0.52–0.59) throughout the year. In Beijing, Model B’s UDI decreased by 0.2%, while Model C increased by 6.55%. Glare areas reduced by 2.92% and 14.35%, with improved winter comfort (PMV −0.35 to −0.1). In Shanghai, Model C’s UDI increased by 6.7%, but summer thermal discomfort was notable (PMV up to 1.2). The study finds that PV shading systems combined with vertical farming can provide significant energy savings, reduce greenhouse gas emissions, and offer organic vegetable production within school environments. The findings suggest that integrating these systems into the building envelope can optimize the energy performance of school buildings while improving the comfort and well-being of students and staff.

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Barros, Roberto Augusto, Maria Jose Monteverde, Jean-Marc Dumonceau, Augusto Sebastian Barros, German Luis Rainero, Roberto Federico Barros, Maria Jose Jaroslavsky, and Santiago de Elizalde. "Cold snare polypectomy without submucosal injection: safety and efficacy in 615 large serrated lesions." Endoscopy International Open 09, no. 09 (August 23, 2021): E1421—E1426. http://dx.doi.org/10.1055/a-1517-4054.

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Abstract Background and study aim Cold resection is becoming the standard of care for the resection of nonpedunculated colon lesions up to 10 mm in diameter. Sessile serrated adenomas/polyps (SSA/Ps), including those ≥ 10 mm, present various characteristics that make them ideal candidates for cold snare polypectomy (CSP). Patients and methods A prospectively maintained database was searched retrospectively for consecutive patients with lesions ≥ 10 mm resected between March 2013 and March 2018. During that period, all SSA/P-appearing lesions were resected using CSP without submucosal injection, except for lesions with endoscopic suspicion of dysplasia or submucosal invasion. Patients with a pathological diagnosis of SSA/P were included in the analysis. Adverse events were recorded up to 21 days following colonoscopy. Results 615 SSA/Ps ≥ 10 mm were resected during 452 colonoscopy procedures in 379 patients (mean age 54.1 years; standard deviation [SD] 11.9 years). Mean polyp size was 13.7 (SD 5.2) mm; 122 lesions (19.8 %) were ≥ 20 mm and 479 lesions (77.9 %) underwent piecemeal resection. Immediate adverse events included persistent abdominal pain that resolved spontaneously within 2 hours in three patients (0.8 %; 95 % confidence interval [CI] 0.2 %–2.3 %). One patient with persistent intraprocedural bleeding was successfully treated with a hemostatic clip. No late adverse events were detected. Surveillance colonoscopy was performed in 293 patients (77.3 %) at 23.4 (SD 11.6) months following index colonoscopy; residual/recurrent lesions were diagnosed in 23 patients (7.8 %; 95 %CI 5.0 %–11.6 %). Conclusion CSP without submucosal injection appeared to be safe and effective for the resection of large SSA/Ps.

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Stackhouse, S., E. Grafstein, and G. Innes. "LO82: Does triage assignment correlate with outcome for ed patients presenting with chest pain?" CJEM 21, S1 (May 2019): S37. http://dx.doi.org/10.1017/cem.2019.124.

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Introduction: CTAS triage acuity and CEDIS complaint categories are used to prioritize patients for rapid treatment and ED resource allocation. Our objective was to evaluate CTAS and CEDIS validity for risk stratification of ED patients with chest pain using data from two Canadian cities. Methods: This administrative database study included patients seen over a five-year period with a triage complaint of chest pain. Our composite primary outcome included 7-day mortality, cardiac arrest, acute coronary syndrome (ACS) diagnosis (STEMI, NSTEMI, unstable angina{UA}), admission to a critical care unit, or hospitalization with CHF, pulmonary embolism, dysrhythmia, aortic pathology, neurologic or respiratory diagnosis. We dichotomized triage assignments to cardiac vs. noncardiac chest pain and high (CTAS 1,2) vs. low (3,4,5) triage acuity. For our secondary outcome we reported the components of the primary composite outcome. Results: We studied 111,824 patients. The most common overall diagnoses were chest pain NYD (53.8%), ACS (8.9%), musculoskeletal (7.4%), and acute respiratory (5.5%) or GI (5.1%) conditions. Of all patients studied, 85,888 (76.8%) were placed in the “cardiac features” group, and 93,257 (83.4%) fell into high acuity CTAS 1-2. Patients triaged into the “cardiac features” group were more likely to have a composite outcome event (16.6% v. 6.7%; p < 0.001), to be admitted (21.8% v. 9.0%), to require critical care (6.0% v. 0.7%), to receive an ACS diagnosis (11.3% v. 0.9%), and to die within 7 days (0.5% v. 0.2%). Patients in high acuity triage levels were also more likely to have a composite outcome event (15.8% v. 3.3%; p < 0.001), to be admitted (25.4% v. 14.3%), to require critical care (8.2% v. 1.2%), to receive an ACS diagnosis (10.5% v. 0.9%), and to die within 7 days (0.5% v. 0.2%). Conclusion: This study shows that triage assignment is strongly correlated with important patient outcomes and that both the chief complaint and acuity level are powerful risk predictors. These findings may differ at other sites and hospitals should assess and evaluate their data.

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Maděra, Petr, Radomír Řepka, Jan Šebesta, Tomáš Koutecký, and Martin Klimánek. "Vascular plant biodiversity of floodplain forest geobiocoenosis in Lower Morava river Basin (forest district Tvrdonice), Czech Republic." Journal of Landscape Ecology 6, no. 2 (December 1, 2013): 34–64. http://dx.doi.org/10.2478/v10285-012-0067-3.

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ABSTRACT This paper presents an evaluation of full-area floristic mapping of floodplain forest in Tvrdonice forest district (Židlochovice Forest Enterprise) based on a single forest stand inventory. The study area encompasses 2,200 ha of forests, where 769 segments were inventoried, and 46,886 single records about presence of vascular plant species were catalogued. We found 612 species (incl. subspecies and hybrids), out of which 514 were herbs, 98 were woody plants, 113 were endangered species and 170 were adventive species. The average area of a segment is 2.86 ha. The mean number of species per segment is 60.97 in a range of 4-151.

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Bialik, E. I., M. A. Makarov, V. A. Nesterenko, V. E. Bialik, A. E. Karateev, A. A. Bialik, and V. I. Stadnik. "Evaluation of the efficacy of high molecular weight hyaluronic acid with chondroitin sulfate in post-traumatic knee osteoarthritis." Modern Rheumatology Journal 18, no. 4 (August 20, 2024): 59–65. http://dx.doi.org/10.14412/1996-7012-2024-4-59-65.

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Objective: to evaluate the efficacy of a single or double administration of a preparation of high molecular weight hyaluronic acid (HLA) with chondroitin sulfate (CS) in post-traumatic knee osteoarthritis (OA). Material and methods. The study included 91 patients with stage III post-traumatic knee OA. All patients received intra-articular (i/a) injection of high molecular weight HLA with CS; 36 patients received the drug once (group 1) and 55 twice (group 2) with an average interval of 7±2 days. Before the start of treatment and 2 weeks, 1, 3, 6 and 12 months after i/a injection of HLA, pain intensity at rest and during movement was assessed using a visual analogue scale (VAS) and function was assessed using KOOS questionnaire (Knee injury and Osteoarthritis Outcome Score). Results and discussion. In general, patients receiving single and double i/a injections of HLA, pain during movement at baseline, and after 2 weeks, 1, 3, 6 and 12 months was 6.7±1.1; 4.0±0.7; 4.3±0.8; 4.6±1.0; 4.5±1.1 and 5.3±0.4 cm; pain at rest – 2.7±0.6; 1.5±0.2; 1.8±0.2; 2.1±0.5; 2.2±0.3 and 2.6±0.2 cm, and KOOS score was 35.9±13.6; 43.5±13.6; 49.2±17.6; 57.0±12.5; 51.5±11.7 and 40.3±10.2, respectively. In group 1, pain during movement at the same time line reached 6.7±1.2; 4.0±0.7; 4.3±1.1; 4.6±.08; 4.5±0.6 and 5.3±1.3 cm; pain at rest – 2.7±0.5; 1.5±0.3; 1.8±0.4; 2.1±0.4; 2.2±0.6 and 2.6±0.6 cm; KOOS score – 37.2±8.7; 39.1±10.1; 43.0±12.3; 47.0±13.6; 49.5±14.7 and 35.7±12.4, respectively.In the 2nd group, pain during movement was 6.1±1.5; 3.3±0.7; 3.6±0.6; 3.4±0.5; 3.7±0.4 and 4.4±0.3 cm; pain at rest was 2.6±0.3; 1.9±0.2; 1.1±0.2; 0.9±0.1; 0.7±0.1 and 1.7±0.3 cm; KOOS score was 34.7±9.4; 47.1±11.1; 59.3±11.5; 61.4±12.7; 57.2±14.3 and 45.7±12.4, respectively. Conclusion. In patients with stage III knee OA, double injections of HLA with HS were more effective. The maximum pain reduction and functional improvement were observed in the first 3 months after local injection therapy.

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Arif, A. A., K. Donaldson, H. Qian, E. Lam, and N. C. Shahidi. "A123 MINIMALLY INVASIVE ENDOSCOPIC RESECTION TECHNIQUE PERFORMANCE FOR PERI-APPENDICEAL COLORECTAL NEOPLASIA: A SYSTEMATIC REVIEW AND META-ANALYSIS." Journal of the Canadian Association of Gastroenterology 5, Supplement_1 (February 21, 2022): 144–45. http://dx.doi.org/10.1093/jcag/gwab049.122.

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Abstract Background Minimally invasive endoscopic resection techniques, including endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD) and endoscopic full-thickness resection (EFTR) have revolutionized the management of peri-appendiceal colorectal neoplasia. However, questions remain about their comparative performance. Aims We sought to evaluate the performance of EMR, ESD and EFTR for peri-appendiceal colorectal neoplasia. Methods Two authors independently searched MEDLINE, EMBASE and Cochrane Libraries (Jan 2000 – Aug 2021) for citations evaluating the performance of endoscopic resection techniques (EMR, ESD, EFTR) for peri-appendiceal colorectal neoplasia (defined as those involving or in close proximity to the appendiceal orifice). The incidence rates and 95% confidence intervals (95% CI) of technical success (complete removal of all neoplastic tissue at index procedure), clinically significant post-endoscopic resection bleeding (CSPEB), delayed perforation, recurrence and referral to surgery were assessed using random-effects modelling. Results 12 studies were included in the analysis (479 patients: 185 EMR, 171 ESD, 123 EFTR). Technical success was achieved in 93.5% (95% CI 90.9%-95.4%, EMR 93.5%, ESD 94.1%, EFTR 92.7%). Clinically significant post-endoscopic resection bleeding occurred in 1.3% (95% CI 0.4%-4.3%, EMR 3.8%, ESD 1.2%, EFTR 0%). Delayed perforation occurred in 1.9% (95% CI 0.9%-3.9%, EMR 0%, ESD 2.4%, EFTR 2.4%). Recurrence occurred in 5.7% (95% CI 2.3%-13.8%, EMR 14.3%, ESD 0.2%, EFTR 12.2–14.3%). Referral to surgery occurred in 9.0% (95% CI 6.7%-12.0%, EMR 8.1%, ESD 9.5%, EFTR 9.8%). Conclusions Minimally invasive endoscopic resection techniques including EMR, ESD and EFTR demonstrate high frequencies of technical success with comparable adverse event profiles. They should now be viewed as first-line therapeutic modalities for the management of peri-appendiceal colorectal neoplasia. Funding Agencies None

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Ichinose, Masashi, and Takeshi Nishiyasu. "Muscle metaboreflex modulates the arterial baroreflex dynamic effects on peripheral vascular conductance in humans." American Journal of Physiology-Heart and Circulatory Physiology 288, no. 4 (April 2005): H1532—H1538. http://dx.doi.org/10.1152/ajpheart.00673.2004.

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We aimed to investigate the interaction between the arterial baroreflex and muscle metaboreflex [as reflected by alterations in the dynamic responses shown by leg blood flow (LBF: by the ultrasound Doppler method), leg vascular conductance (LVC), mean arterial blood pressure (MAP), and heart rate (HR)] in humans. In 12 healthy subjects (10 men and 2 women), who performed sustained 1-min handgrip exercise at 50% maximal voluntary contraction followed immediately by an imposed postexercise muscle ischemia (PEMI), 5-s periods of neck pressure (NP; 50 mmHg) or neck suction (NS; −60 mmHg) were used to evaluate carotid baroreflex function both at rest (Con) and during PEMI. First, the decreases in LVC and LBF and the augmentation of MAP elicited by NP were all greater during PEMI than in Con (ΔLVC, −1.2 ± 0.2 vs. −1.9 ± 0.2 ml·min−1·mmHg−1; ΔLBF, −97.3 ± 11.2 vs. −177.0 ± 21.8 ml/min; ΔMAP, 6.7 ± 1.2 vs. 11.5 ± 1.4 mmHg, Con vs. PEMI; each P < 0.05). Second, in Con, NS significantly increased both LVC and LBF (ΔLVC, 0.9 ± 0.2 ml·min−1·mmHg−1; ΔLBF, 46.6 ± 9.8 ml/min; significant change from baseline: each P < 0.05), and, whereas during PEMI no significant increases in LVC and LBF occurred during NS itself (ΔLVC, 0.2 ± 0.1 ml·min−1·mmHg−1; ΔLBF, 10.8 ± 9.6 ml/min; each P > 0.05), a decrease was evident in each parameters at 5 s after the cessation of NS. Third, during PEMI, the decrease in MAP elicited by NS was smaller (ΔMAP, −8.4 ± 1.0 vs. −5.8 ± 0.4 mmHg, Con vs. PEMI; P < 0.05), and it recovered to its initial level more quickly after NS (vs. Con). Finally, however, the HR responses to NS and NP were not different between PEMI and Con. These results suggest that during muscle metaboreflex activation in humans, the arterial baroreflex dynamic effect on peripheral vascular conductance is modulated, as exemplified by 1) an augmentation of the NP-induced LVC decrease, and 2) a loss of the NS-induced LVC increase.

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Nguyen Ngoc, Chinh, and Sho Shirakashi. "The first record of $\textit{Kudoa yasunagai}$ (Hsieh & Chen, 1984) (Myxosporea: Multivalvulida) parasitizing the brain of barhead spinefoot $\textit{Siganus virgatus}$ (Valenciennes) from Vietnam." Academia Journal of Biology 46, no. 1 (March 29, 2024): 87–97. http://dx.doi.org/10.15625/2615-9023/19453.

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A brain-infecting myxozoan, Kudoa yasunagai (Hsieh & Chen, 1984), was identified using both morphological and molecular methods in a marine fish from Van Phong Bay, Khanh Hoa province, Vietnam. Cysts containing spores were observed in the brain of one out of 10 Siganus virgatus (Valenciennes) individuals (10%). The myxospores were radially symmetrical, containing a majority of 7 equal shell valves and polar capsules. The spores measured 6.6 ± 0.1 (6.4‒6.7) µm in length, 7.6 ± 0.5 (7.0‒8.4) µm in width, and 7.0 ± 0.4 (6.5‒7.7) µm in thickness. Polar capsules measured 2.8 ± 0.2 (2.6‒3.0) µm in length and 1.4 ± 0.1 (1.2‒1.5) µm in width, containing a filament inside. The SSU rDNA sequence from the Vietnamese specimen showed > 99.94 % identity with K. yasunagai from Japan and Australia. This report marks a new geographical and host record for K. yasunagai.

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Silva, Aldeir R., Francisco T. C. Bezerra, Lourival F. Cavalcante, Walter E. Pereira, Leandro M. Araújo, and Marlene A. F. Bezerra. "Biomass of sugar-apple seedlings under saline water irrigation in substrate with polymer." Revista Brasileira de Engenharia Agrícola e Ambiental 22, no. 9 (September 2018): 610–15. http://dx.doi.org/10.1590/1807-1929/agriambi.v22n9p610-615.

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ABSTRACT Application of saline water causes water and salt stress, changing the behavior of the plants. The aim of this work was to evaluate the accumulation and allocation of biomass in sugar-apple seedlings under frequencies of irrigation with saline water in a substrate with soil conditioner, as well as the effect of container volume. The treatments were obtained from the arrangement between polymer doses (0, 0.2, 0.6, 1.0 and 1.2 g dm-3) and electrical conductivity of irrigation water (0.3; 1.1; 2.7; 4.3 and 5.0 dS m-1), associated with irrigation frequencies (daily and alternated), plus two additional treatments to evaluate container volume (0.75 and 1.30 dm3), distributed in blocks. The evaluations were performed at 120 days after sowing. Irrigation frequency affected the variables, and the highest values were obtained with daily irrigation, except for root/shoot dry matter ratio. Increase in the electrical conductivity of the irrigation water inhibited biomass accumulation. The effect of the container was significant for daily irrigation; higher volume led to higher root, shoot and total biomass. Polymer doses did not affect the biomass of the seedlings. Daily irrigation with non-saline water favored biomass production in sugar-apple seedlings. In the production of sugar-apple seedlings, water with electrical conductivity below 1.0 dS m-1 should be used on a daily frequency of application in 1.30 dm3 containers.

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King, booker, Elisabeth A. Carter, Dabbs William, Chris B. Agala, Lori Chrisco, and Felicia Williams. "611 Comparison of Autologous Skin Cell Suspension to Conventional Surgical Treatment in Burn Patients." Journal of Burn Care & Research 45, Supplement_1 (April 17, 2024): 192. http://dx.doi.org/10.1093/jbcr/irae036.244.

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Abstract Introduction In 2018, a device was approved for the treatment of burn injuries. This autologous cell harvesting device is used for the delivery of a regenerative cell suspension, utilizing a patient’s own skin. The study aims to examine outcomes of the device compared to conventional surgical treatment in adult burn patients. Methods A retrospective study of burn outcomes in burn patients, admitted from 2015-2022 to a single burn center, was conducted investigating the clinical performance of the autologous skin cell suspension (ASCS) to conventional surgical treatment. Patients ≥18 years of age, with a total body surface area (TBSA) of ≥20% were included. Data were collected utilizing the burn registry and chart review. Patients were divided into two groups: those who received ASCS and those who received conventional surgical treatment (control). We used Fisher’s exact and chi square tests to compare categorical variables, Wilcoxon rank sum test for continuous variables to conduct between-group comparisons, and generalized linear models to assess associations between predictors and outcomes. Results A total of 229 patients were identified, 78 were treated with ASCS, and 151 patients received control. Baseline characteristics were comparable in the two groups. The average cost for the ASCS group was $1,244,219 while the control group was $866,072 which was statistically significant. Mean post-hospital plastics clinic visits in the ASCS group was 6.1 and 6.7 in the control group. The mean burn clinic visits was 4.2 among ASCS patients, compared to 3.7 in control group. After adjustment from baseline characteristics, the ASCS group were less likely to be on a ventilator (OR: 0.31, 95% CI: 0.13-0.70); had 1.2 times the number of burn clinic visits than control (IRR: 1.2, 95% CI: 1.03-1.39); LOS for the ASCS group was 0.86 times that of the control group (IRR:0.86, 95% CI: 0.83-0.89); and wound healing was lower (0.82 times) than that of control (IRR:0.82, 95% CI:0.79-0.84); shorter ICU LOS (IRR: 0.56, 95% CI:0.53-0.59); fewer plastics clinic visits (IRR:0.84, 95% CI: 0.70-0.99); fewer vent days (IRR:0.55, 95% CI: 0.52-0.58); 7% higher hospital cost (IRR:1.07, 95% CI: 1.07-1.07). There was no difference in mortality between the groups. Conclusions The findings of this study show that receipt of ASCS may be beneficial to some patients by reducing the likelihood of ventilator dependence, quicker wound healing, shorter ICU stay, shorter hospital LOS, fewer plastics clinic visits and slightly higher hospital cost, but no difference in mortality. There is a need for a multi-center, retrospective study to better understand the benefits of using an autologous skin harvesting device in the treatment of large burns. Applicability of Research to Practice Further understanding the impact of surgical interventions will assist in better surgical outcomes in the burn population.

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Adebisi, K. A. "Age – Related changes in serum biochemical parameters in the domestic rabbit (Oryctolagus cuniculus)." Nigerian Journal of Animal Production 45, no. 5 (December 26, 2020): 67–71. http://dx.doi.org/10.51791/njap.v45i5.211.

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The influence of age on serum biochemical components in the domestic rabbit was investigated. The serum total protein (g/dL), albumin (g/dL), globulin (g/dL), creatinine (mg/dL), urea mg/dL, cholesterol (mg/dL), Alkaline phosphatase (ALP; iu/l), Aspartate aminotranferase (AST; iu/l) and Alanine amimotransferase (ALT; iu/l) were assessed in 24 male rabbits at 7, 14 and 21 weeks of age to represent weaners, growers and pubertal stages. Data were analysed using descriptive statistics and analysis of variance at á . Results of 0.05 serum biochemistry revealed a steady significant increase in total protein (4.2±0.3; 5.3±0.5; 6.9±0.2), albumin (2.2±0.7; 2.8±0.4; 4.0±0.2), globulin (1.9±0.3; 2.5±0.4, 2.9±0.2), cholesterol (49.5±1.1; 56.4±4.2; 62.4±5.4) and creatinine (0.8±0.1; 1.2±0.1; 1.9±0.3) at 7, 14 and 21 weeks respectively. Serum urea levels were similar across the ages. The values recorded for ALP and AST at 7 weeks (39.6±7.5; 101.1±6.7) and 14 weeks (38.7±6.4; 104.5±8.7) were significantly higher than the 21 weeks (33.5±2.7; 95.8±5.9) while ALT at 7 weeks (27.33±5.6) was significantly lower than 14 (38.2±3.9) and 21 weeks (37.4±3.0). The age of the rabbits had a significant effect on their serum biochemical parameters. They should therefore be grouped according to age when setting serum reference values for them.

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Faría-Mármol, J., J. González, C. A. Rodríguez, and M. R. Alvir. "Effect of diet forage to concentrate ratio on rumen degradability and post-ruminal availability of protein from fresh and dried lucerne." Animal Science 74, no. 2 (April 2002): 337–45. http://dx.doi.org/10.1017/s1357729800052498.

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AbstractThe ruminal degradation of dry matter (DM) and crude protein (CP) and the intestinal availability of CP of four lucerne samples were measured on two diets with lucerne hay to concentrate ratios of 2: 1 (diet F) and 1: 2 (diet C). Two samples of fresh lucerne (third cut) harvested after 2 (FL1) or 8 (FL2) weeks from the previous cut were used together with a sample of lucerne hay (LH) and another of dehydrated lucerne (DL). Rumen degradability, measured by the nylon bag technique, and rumen outflow rates were determined on three rumen cannulated wethers. Intestinal digestibility was determined by the mobile bag technique on three duodenal fistulated wethers. For CP, significantly lower values were observed with diet C than with diet F for the potentially degradable insoluble fraction (0·334 v. 0·397) and its degradation rate (0·093 v. 0·134 per h). As a consequence, the effective degradability was also lower with diet C (0·746 v. 0·821; P = 0·059). Effective degradability of DM was also apparently lower with diet C (0·596 v. 0·634). With both diets, the intestinal digestibility decreased in all the samples with increase of ruminal incubation time according to a simple exponential equation. The undegraded CP digested in the gut (Di) and therefore the effective intestinal digestibility (EID) were derived from this exponential function according to the rumen outflow of undegraded CP. Mean values of Di (expressed as proportion of food CP content) were respectively 0·091 and 0·142 for F and C diets and 0·084, 0·115, 0·116, and 0·152 for FL1, FL2, LH and DL samples. Lower rumen degradability was partially compensated for by higher Di values resulting in a close correlation between both parameters (r = –0·965; P 0·001). The change of the digestion site associated with the reduction of the effective degradability of CP produced also an increase in the undigested CP as a proportion of food CP. So, these values are respectively 0·087 and 0·112 for F and C diets and 0·053, 0·109, 0·096, and 0·141 for FL1, FL2, LH, and DL samples. No difference in EID between F and C diets was observed (0·529 v. 0·563). For samples, the only effect (P 0·05) was recorded between FL1 (0·618) and the other samples (0·509, 0·544 and 0·512 for FL2, LH, and DL, respectively).

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