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Quantin, Jean-Louis. "Pierre de Bérulle, Œuvres complètes, t. 12. Correspondance [IV]. Lettres (616‑848), texte établi et." Revue de l'histoire des religions, no. 234 (March 1, 2017): 173–76. http://dx.doi.org/10.4000/rhr.8702.
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Mazzocco, Mariel. "Pierre de Bérulle, Œuvres complètes, t. 12. Correspondance [IV]. Lettres (616‑848), texte établi et annoté par Blandine." Revue de l'histoire des religions, no. 233 (September 1, 2016): 455–57. http://dx.doi.org/10.4000/rhr.8616.
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Gould, G. "Review: Barsanuphe et Jean de Gaza. Correspondance. Volume III. Aux laics et aux eveques. Lettres 617-848." Journal of Theological Studies 54, no. 1 (April 1, 2003): 472–73. http://dx.doi.org/10.1093/jts/54.1.472.
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Kim, Jang Hoon, Sunggun Lee, Saerom Park, Ji Soo Park, Young Ho Kim, and Seo Young Yang. "Slow-Binding Inhibition of Tyrosinase by Ecklonia cava Phlorotannins." Marine Drugs 17, no. 6 (June 16, 2019): 359. http://dx.doi.org/10.3390/md17060359.
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Tyrosinase inhibitors improve skin whitening by inhibiting the formation of melanin precursors in the skin. The inhibitory activity of seven phlorotannins (1–7), triphlorethol A (1), eckol (2), 2-phloroeckol (3), phlorofucofuroeckol A (4), 2-O-(2,4,6-trihydroxyphenyl)-6,6′-bieckol (5), 6,8′-bieckol (6), and 8,8′-bieckol (7), from Ecklonia cava was tested against tyrosinase, which converts tyrosine into dihydroxyphenylalanine. Compounds 3 and 5 had IC50 values of 7.0 ± 0.2 and 8.8 ± 0.1 μM, respectively, in competitive mode, with Ki values of 8.2 ± 1.1 and 5.8 ± 0.8 μM. Both compounds showed the characteristics of slow-binding inhibitors over the time course of the enzyme reaction. Compound 3 had a single-step binding mechanism and compound 5 a two-step-binding mechanism. With stable AutoDock scores of −6.59 and −6.68 kcal/mol, respectively, compounds 3 and 5 both interacted with His85 and Asn260 at the active site.
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Murjaya, Jaya, Suaidi Ahadi, Katsumi Hattori, Aditya Setyo Rahman, Petrus Demon Sili, Dwikorita Karnawati, Dedi Sugianto, Sutiyono, and Sulastri. "Potential impact and return period analysis study of Sumatra paleo megathrust earthquake using scaling law relations of earthquake parameter (case study: Siberut-West Sumatra megathrust earthquake 1797, Mw 8.2 ~ 8.8)." E3S Web of Conferences 464 (2023): 07003. http://dx.doi.org/10.1051/e3sconf/202346407003.
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The paleo-megathrust earthquake occurred in Siberut, West Sumatra in 1797 and it was estimated to have a magnitude (Mw) of about 8.2–8.8. This earthquake triggered a tsunami in the West Sumatra coast and its vicinity. The seismograph was not installed yet at that time, therefore it didn’t has earthquake parameter for advanced analysis. This study hoped to be able to see the earthquake potential impact if the earthquake occurred in this present era. Hereinafter using the scaling law relations of earthquake kinematic model in processing. The result is maximum intensity in Siberut and Tanahbala islands about VII-IX MMI, Painan, Padang, and Pariaman cities about V-VII MMI, and the northern part of West Sumatra region about VI-VII MMI. The PGA in Siberut and Tanahbala is about 60 % g, and Painan, Padang, and Pariaman are about 20 % g or more. Then the value of PGV in Siberut and Tanahbala is about 60 cm/s, in Painan about 10-20 cm/s, and in Padang and Pariaman city about 20-30 cm/s. Furthermore, an estimation of the return period of the earthquake if the source mechanism was modelled as a thrust and strike-slip faults for Mw 8.2-8.8 about 185 until 235 years and 336 until 616 years respectively.
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Ogunwande, Isiaka A., Razaq Jimoh, Adedoyin A. Ajetunmobi, Nudewhenu O. Avoseh, and Guido Flamini. "Essential oil Composition of Ficus Benjamina (Moraceae)and Irvingia Barteri (Irvingiaceae)." Natural Product Communications 7, no. 12 (December 2012): 1934578X1200701. http://dx.doi.org/10.1177/1934578x1200701233.
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Essential oils obtained by hydrodistillation of leaves of two Nigerian species were analyzed for their constituents by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The leaf oil of Ficus benjamina L. (Moraceae), collected during the day, contained high contents of α-pinene (13.9%), abietadiene (9.7%), cis-α-bisabolene (8.2%) and germacrene-D-4-ol (8.4%), while the night sample was dominated by germacrene-D-4-ol (31.5%), 1,10-di- epi-cubenol (8.8%) and hexahydrofarnesylacetone (8.3%). This could be a possible indication of differences in emissions of volatiles by F. benjamina during the day and night. The main compounds of Irvingia barteri Hook. f. (Irvingiaceae) were β-caryophyllene (17.0%), (E)-α-ionone (10.0%), geranial (7.6%), (E)-β-ionone (6.6%) and β-gurjunene (5.1%).
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Kang, Ting Hu, Xiao Yan Fan, and Ting Ting Ren. "Structure of Undergraduate's Employability: Exploring and Measurement." Advanced Materials Research 718-720 (July 2013): 709–14. http://dx.doi.org/10.4028/www.scientific.net/amr.718-720.709.
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Based on the literature review and baseline survey, this study was carried out to explore the structure of undergraduates employability under the background of China. 612 students as the subjects were predicted, the items were formed through exploratory factor analysis. The results indicated that undergraduates employability comprised two longitudinal dimensionalities: job-attain and job-maintain; and the horizontal dimension were two stage structure with 3 second-order factors and 7 one-order factors. Then 412 students were investigated to test the validity and reliability of the undergraduates employability cognition scale. The scale was found to have a good internal reliability coefficient (a=.928) and Spearman-Brown coefficient (r=.852) of job-attain dimension, the job-maintain dimension were .927 and .845 respectively.
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Yan, Zhen, and Frank W. Booth. "Cytochrome c promoter activity in soleus and white vastus lateralis muscles in rats." Journal of Applied Physiology 85, no. 3 (September 1, 1998): 973–78. http://dx.doi.org/10.1152/jappl.1998.85.3.973.
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Cytochrome c protein and mRNA are 300 and 100% higher, respectively, in the soleus muscle (predominantly slow-twitch oxidative) than the white vastus lateralis (predominately fast-twitch glycolytic) muscle (W. W. Winder, K. M. Baldwin, and J. O. Holloszy. Eur. J. Biochem. 47: 461–467, 1974; M. M. Lai and F. W. Booth. J. Appl. Physiol. 69: 843–848, 1990). However, the mechanisms controlling these differences in cytochrome c mRNA are largely unknown. The present study employed direct plasmid injection techniques to determine whether the proximal promoter (−726 to +610) of the rat somatic cytochrome c gene was more active in the soleus than in white vastus lateralis muscles in rats. No difference between the soleus and white vastus lateralis muscles for the activities of the −726, −631, −489, −326, −215, −159 and −149 cytochrome c promoters was noted. The results of this study suggest that additional elements (outside of −726 to +610) in the cytochrome c gene may be required, or posttranscriptional regulation may account, for the higher cytochrome c mRNA in the slow-twitch oxidative muscle.
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Bateman, Francis, Oluwatobi Arisa, Natalia Corvalan Cabanas, Yi Zeng, Cody Peer, Keith Schmidt, and William Douglas Figg. "Abstract 7184: Simulating extended dosing intervals for atezolizumab: A comparative analysis between NONMEM and Pumas." Cancer Research 84, no. 6_Supplement (March 22, 2024): 7184. http://dx.doi.org/10.1158/1538-7445.am2024-7184.
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Abstract The initially approved dosage regimens of 840 mg every 2 weeks, 1200 mg every 3 weeks, and 1680 mg every 4 weeks are considered excessive concerning the specified minimum effective concentration of 6 ug/mL and the significant exposure-response relationship with Adverse Events of Special Interest (AESI). Our previous research, demonstrated through simulation, indicated that an extended-interval dosing regimen (840 mg every 6 weeks) after two standard loading doses maintained efficacy with a nonsignificant exposure-response relationship with AESI.In alignment with the FDA's initiative "Project Optimus," which aims to optimize drug dosing for improved therapeutic outcomes, we explore alternative dosage regimens for atezolizumab. Through a comparison of the traditional 30-year-old industry standard NONMEM software and the recently developed PumasAI software, we simulate these regimens, utilizing our previously published article as a benchmark. Given the rapid evolution of artificial intelligence (AI) and machine learning, it is crucial for pharmacokinetic modeling to adapt and leverage these advancements. We anticipate that this paper will contribute to the integration of AI and machine learning software in pharmacokinetic analysis, aligning with the goals of "Project Optimus" to ensure that drug concentrations are optimized for efficacy and safety. Table 1: Comparative Summary of Simulated Pharmacokinetic Parameters: Pumas vs. NONMEM Pumas NONMEM Regimen Cycle Week Cmax (ug/mL) Cmax (ug/mL) Cmax (ug/mL) Cmax (ug/mL) Cmin (ug/mL) Weekly AUC (ug*day/mL) 1200 mg q3w 1st 3 384(278-533) 64.1(31.4-112) 919(640-1290) 394 (278-559) 75.6 (44.5-121) 1003 (755-1342) 7th 21 541(371-795) 146(53.8-349) 1750(977-3210) 583 (414-847) 180 (75.9-396) 2014 (1169-3535) 840 mg q2w x2, 840 mg q6w 1st 2 270(195-379) 61.6(35.5-100) 775(570-1085) 275 (184-397) 71.2 (46.4-108) 834 (620-1131) 7th 38 314(221-448) 33.6(8.8-127) 650(357-1375) 336 (235-487) 46.9 (13.5-150) 774 (441-1562) 1200 mg q3w x2, 840 mg q6w 1st 3 384(278-533) 64.1(31.4-112) 919(640-1290) 394 (278-559) 75.6 (44.5-121) 1003(755-1342) 7th 39 316(224-459) 36.0(8.4-129) 670(340-1406) 327 (217-492) 46.6 (13.4-157) 763 (411-1594) 1680 mg q4w x2, 840 mg q6w 1st 4 545(380-779) 63.1(26.9-122) 1096(735-1555) 552 (375-793) 78.1 (40.7-135) 1203(869-1651) 7th 40 318(222-469) 33.9(7.7-126) 657(343-1385) 332 (227-491) 46.5 (13.6-140) 771 (436-1464) Citation Format: Francis Bateman, Oluwatobi Arisa, Natalia Corvalan Cabanas, Yi Zeng, Cody Peer, Keith Schmidt, William Douglas Figg. Simulating extended dosing intervals for atezolizumab: A comparative analysis between NONMEM and Pumas [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 7184.
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Karam, Dhauna, Robert A. Vierkant, Shawna Ehlers, Rachel A. Freedman, Nicole Larson, Charles L. Loprinzi, Fergus Couch, Janet Olson, and Kathryn J. Ruddy. "Abstract 5262: Physical function, mental health, and overall health of older breast cancer survivors." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5262. http://dx.doi.org/10.1158/1538-7445.am2022-5262.
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Abstract Introduction: Patients at extremes of age may be particularly vulnerable to poor physical and mental health after treatment for breast cancer; we examined factors associated with poor health in older breast cancer survivors. Methods: The Mayo Clinic Breast Disease Registry (MCBDR) is a prospective longitudinal cohort study that enrolls Mayo Clinic Rochester patients diagnosed with stage 0-4 breast cancer (BC). In 2020, we mailed a survey to 1,273 MCBDR participants aged 77+. Three PROMIS-10 items were used to assess overall health, mental health, and physical function. Self-reported comorbidities were also collected. Multivariate logistic regression analysis was used to identify significant (p<0.05) predictors of overall health, mental health, and physical function. Independent variables included demographics, clinical characteristics, and comorbidities. Results: 848/1273 MCBDR participants (67%) responded, 842 reporting their overall health. Median age at survey return was 82 years (range 77-100), and the median time since cancer diagnosis was 12 years. Excellent or very good overall health, mental health, and physical function were reported by 48%, 63.5%, and 77.1%, respectively. Older age was associated with poorer self-reported overall health, as were heart disease, diabetes, and lung disease, reported by 18%, 14%, and 7%, respectively (p<0.05 for all; see Table). Only heart disease was statistically significantly associated with poorer mental health (p=0.03). Physical function was reportedly better in survivors without a history of diabetes, stroke, or lung disease (p<0.05 for all), and in those who were closer to their cancer diagnosis (p=0.03). Tumor characteristics were not associated with overall health, mental health, or physical function. Conclusions: Comorbidities are common and impact self-reported overall health, mental health, and physical function in older breast cancer survivors. Table: Multivariate logistic regression model for overall health Overall health self-reported as excellent or very good No Yes Total p-value (N=437) (N=405) (N=842) Age at survey (years) <.001 Mean (SD) 82.8 (4.22) 81.7 (3.85) 82.3 (4.08) Median (range) 82.0 (77.0, 96.0) 81.0 (77.0, 100.0) 82.0 (77.0, 100.0) Years from cancer diagnosis to survey 0.708 Mean (SD) 12.1 (5.16) 11.8 (5.47) 11.9 (5.31) Median (range) 12.2 (3.1, 36.9) 11.5 (3.1, 36.4) 12.0 (3.1, 36.9) T stage T2 or higher, n (%) 0.276 No 357 (81.7%) 337 (83.2%) 694 (82.4%) Yes 80 (18.3%) 68 (16.8%) 148 (17.6%) N stage N1 or higher, n (%) 0.185 No 376 (86.0%) 339 (83.7%) 715 (84.9%) Yes 61 (14.0%) 66 (16.3%) 127 (15.1%) M stage M1, n (%) 0.313 No 434 (99.3%) 404 (99.8%) 838 (99.5%) Yes 3 (0.7%) 1 (0.2%) 4 (0.5%) Race, n (%) 0.460 Non-White 13 (3.0%) 8 (2.0%) 21 (2.5%) White 424 (97.0%) 397 (98.0%) 821 (97.5%) Heart disease, n (%) <.001 No 334 (76.4%) 353 (87.2%) 687 (81.6%) Yes 103 (23.6%) 52 (12.8%) 155 (18.4%) High blood pressure, n (%) 0.376 No 168 (38.4%) 188 (46.4%) 356 (42.3%) Yes 269 (61.6%) 217 (53.6%) 486 (57.7%) Stroke, n (%) 0.195 No 407 (93.1%) 392 (96.8%) 799 (94.9%) Yes 30 (6.9%) 13 (3.2%) 43 (5.1%) Diabetes, n (%) <.001 No 355 (81.2%) 370 (91.4%) 725 (86.1%) Yes 82 (18.8%) 35 (8.6%) 117 (13.9%) Lung disease, n (%) 0.023 No 394 (90.2%) 386 (95.3%) 780 (92.6%) Yes 43 (9.8%) 19 (4.7%) 62 (7.4%) Liver disease, n (%) 0.345 No 425 (97.3%) 401 (99.0%) 826 (98.1%) Yes 12 (2.7%) 4 (1.0%) 16 (1.9%) Kidney disease, n (%) 0.240 No 408 (93.4%) 392 (96.8%) 800 (95.0%) Yes 29 (6.6%) 13 (3.2%) 42 (5.0%) Citation Format: Dhauna Karam, Robert A. Vierkant, Shawna Ehlers, Rachel A. Freedman, Nicole Larson, Charles L. Loprinzi, Fergus Couch, Janet Olson, Kathryn J. Ruddy. Physical function, mental health, and overall health of older breast cancer survivors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5262.
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Okada, Kazutake, Sotaro Sadahiro, Hiroshi Miyakita, Gota Saito, Akira Tanaka, and Toshiyuki Suzuki. "Relation between the size of nonmetastatic lymph nodes and outcomes in patients with stage III colorectal cancer." Journal of Clinical Oncology 36, no. 4_suppl (February 1, 2018): 822. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.822.
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822 Background: In stage II colon cancer, retrieval of less than 12 lymph nodes (LNs) is a risk factor for recurrence. We previously reported that the great long-axis diameter of the largest retrieved lymph nodes (maximum LNs) is associated with a higher number of retrieved LNs and better outcomes (Int J Colorectal Dis 2015). We examined whether the long-axis diameter of maximum LNs is a prognostic factor in node-positive stage III colorectal cancer. Methods: The study group comprised 260 patients (pts) with stage III disease who underwent curative resection from 2005 through 2014. Pts who underwent laparoscopic or emergency surgery were excluded. The long-axis diameter was measured on H-E stained specimens and one non-metastatic LN with the greatest long-axis diameter was selected. The cut-off value (COV) for the long-axis diameter was determined by using receiver ROC curves with recurrence or overall mortality as events. Results: Tumors were located in right colon in 86 pts (33%), left colon in 104 pts (40%), and rectum in 70 pts (27%). In pts with rectal cancer, 49 (70%) received chemoradiotherapy (CRT). The mean long-axis diameter was 8.0 ± 3.5 mm. Factors related to the long-axis diameter were tumor location (right colon 9.5 ± 3.8 mm, left colon 7.7 ± 3.4 mm, rectum 6.6 ± 2.4 mm, p < 0.001), CRT (absent 8.4 ± 3.6 mm, present 6.3 ± 2.3 mm, p < 0.001), TNM stage (IIIA 6.6 ± 3.0 mm, IIIB 8.0 ± 3.5 mm, IIIC 8.8 ± 3.7 mm, p = 0.025), and the number of retrieved LNs (less than 12, 6.5 ± 2.9 mm; 12 or more, 9.0 ± 3.5 mm, p < 0.001). The COV for the long-axis diameter from the ROC curves was 8.0 mm. A long-axis diameter of ≥8.0 mm (106 pts 41%) were associated with significantly better outcomes than a long-axis diameter of < 8.0 mm (154 pts 59%) (5y RFS: < 8.0 mm 57%, ≥8.0 mm 70%, p = 0.012). On multivariate analysis, sex (female/male, HR 0.61, p = 0.019), venous invasion (absent/present, HR 0.58, p = 0.042), TNM stage (IIIB/IIIA, HR 3.19, p = 0.021; IIIC/IIIA, HR 3.47, p = 0.033), and the long-axis diameter (≥8.0 mm/ < 8.0 mm, HR 0.55, p = 0.005) were independent prognostic factors. Conclusions: In pts with stage III colorectal cancer, the long-axis diameter of maximum LNs was a prognostic factor. The size of maximum LNs might thus reflect the tumor immunity of the host.
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Jovančević, Milivoj, Dragica Šakić, Vesna Školnik –. Popović, Giovana Armano, and Sonja Oković. "Rezultati mjerenja indeksa tjelesne mase djece u dobi između 2 i 8 godina u Republici Hrvatskoj." Paediatria Croatica 63, no. 3 (September 30, 2019): 95–99. http://dx.doi.org/10.13112/pc.462.
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Istraživanje je obuhvatilo podatke o 144 842 mjerenja visine i tjelesne mase djece u dobi od 24 do 95 mjeseci iz baze podataka programa za primarnu zdravstvenu zaštitu. Izračunate su z vrijednosti indeksa tjelesne mase i obavljena je ekstrapolacija rezultataprema standardnim devijacijama za dobne skupine od 24-35, 36 -47, 48-60, 61-71, 72-83 i 84-95 mjeseci. U dobnoj skupini od 2-5godina ekstremno neishranjenih (-3SD) bilo je u 0,4% mjerenja, umjereno neishranjenih (-2SD) bilo je u 2,9% mjerenja. PrekomjernogTM-a (+2SD) bilo je u 6,6% mjerenja, uz značajno povećanu učestalost u dobnoj skupini od 48-60 mjeseci (6,9%) i češće je prisutna udječaka. Debljina (+3SD) je prisutna u 1,9% mjerenja djece u dobi od 2-5 godina i značajno je češća u dobi od 48 – 60 mjeseci (2,3%)te je češća u dječaka unutar dobne skupine od 48 – 60 mj. U dobnoj skupini od 5- 8 godina ekstremno neishranjenih je bilo 0,5%,neishranjenih 3,4%, s prekomjernim TM-om 22,7%, te djece s debljinom 8,8%. U najstarijoj dobnoj podskupini od 84-95 mjeseci zabilježene su najveće prevalencije svih promatranih kategorija uhranjenosti. U prevalenciji ekstremne neishranjenosti nije zabilježenarazlika s obzirom na spol, dok je u svim drugim kategorijama kod dječaka utvrđena veća prevalencija nego kod djevojčica. Ističe sevisoka prevalencija prekomjerne TM u dječaka od 84-95 mjeseci od 35,1%. Učestalost prekomjerne tjelesne mase i debljine je najvišau priobalju, nešto niža u kontinentalnom dijelu Hrvatske i najniža u gradu Zagrebu.
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Minn, A. Yuriko, Brad H. Pollock, Linda Garzarella, Gary V. Dahl, Larry E. Kun, Jonathan M. Ducore, Atsuko Shibata, James Kepner, and Paul G. Fisher. "Surveillance Neuroimaging to Detect Relapse in Childhood Brain Tumors: A Pediatric Oncology Group Study." Journal of Clinical Oncology 19, no. 21 (November 1, 2001): 4135–40. http://dx.doi.org/10.1200/jco.2001.19.21.4135.
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PURPOSE: To investigate the prognostic significance of surveillance neuroimaging for detection of relapse among children with malignant brain tumors. PATIENTS AND METHODS: A historical cohort study examined all children who experienced relapse from 1985 to 1999 on one of 10 Pediatric Oncology Group trials for malignant glioma, medulloblastoma, or ependymoma. RESULTS: For all 291 patients (median age at diagnosis, 8.2 years), median time to first relapse was 8.8 months (range, 0.6 to 115.6 months). Ninety-nine relapses were radiographic, and 192, clinical; median time to relapse was 15.7 versus 6.6 months, respectively (P = .0001). When stratified by pathology, radiographic and clinical groups showed differences in median time to relapse for malignant glioma (7.8 v 4.3 months, respectively; P = .041) and medulloblastoma (23.6 v 8.9 months, respectively; P = .0006) but not ependymoma (19.5 v 13.3 months, respectively; P = .19). When stratified by early (< 8.8 months) or late (≥ 8.8 months) time to relapse, 115 early relapses were clinical, and 32, radiographic; for late relapses, 77 were clinical, and 67, radiographic (P = .001). Overall survival (OS) from relapse was significantly longer for radiographic compared with clinical detection (median, 10.8 months; 1-year OS, 46% v median, 5.5 months; 1-year OS, 33%; P = .002), but this trend did not retain significance when analyzed by pathology subgroups. CONCLUSION: Surveillance neuroimaging detects a proportion of asymptomatic relapses, particularly late relapses, and may provide lead time for other therapies on investigational trials. During the first year after diagnosis, radiographic detection of asymptomatic relapse was infrequent. A prospective study is needed to formulate a rational surveillance schedule based on the biologic behavior of these tumors.
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Ertenli, A. İ., U. Kalyoncu, O. Karadag, L. Kiliç, A. Akdoğan, I. Dogan, Ş. A. Bilgen, et al. "AB0200 TRENDS IN THE CHOICE OF FIRST BIOLOGIC AND TARGETED SYNTHETIC DMARD IN RHEUMATOID ARTHRITIS PATIENTS: 20-YEARS JOURNEY OF HUR-BIO REAL-LIFE REGISTRY." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 1124.2–1124. http://dx.doi.org/10.1136/annrheumdis-2021-eular.693.
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Background:In the last 20 years, there have been extraordinary improvements and practice-changing developments in the management of rheumatoid arthritis (RA). Exploring the pathogenetic mechanisms first enabled clinicians to use anti-tumor necrosis factor (TNF) alpha agents, then drugs targeting different molecules. Parallel to these developments, treatment guidelines have been changed accordingly. Meanwhile, how these developments have been reflected into the real-word practice is a question of interest.Objectives:In this study, we aimed to explore the first biologic agent trends of our 20-years of single-center experience.Methods:HUR-BIO (Hacettepe University Rheumatology Biologic Registry) is a single center biological disease modifying anti-rheumatic drug (DMARD) registry since 2005. Patients who were started biologics before 2005 were registered retrospectively. In brief; demographic data, treatment-related data (including adverse events) and disease-related data of RA patients have been recorded in HUR-BIO. Until the end of the 2020, 21 different rheumatologists contributed to the development of HUR-BIO. In this study, distribution of the first-line biologic agents was calculated according to 5-year periods starting from the 2001. Also, demographic and serologic data of RA patients were reported.Results:A total of 2080 RA patients was registered in HUR-BIO by the end of 2020. Of these patients, 79.5% was female. Mean age at the starting of bDMARD was 53.3 ± 17.8 years. Rate of rheumatoid factor and anti-cyclic citrullinated peptide positivity was 67.6% and 61.0%, respectively. 65 (3.2%), 335 (16.1%), 858 (41.2%) and 822 (39.5%) patients were prescribed with their first bDMARD in 2001-2005, 2006-2010, 2011-2015 and 2016-2020, respectively. There was a trend towards the increasing prescription of non-Anti-TNF bDMARDs over time.Table 1.Distribution of first biologic DMARDs in RA patients according to 5-years periods2001-20052006-20102011-20152016-2020TotalAdalimumab15 (23.1)111 (33.0)187 (21.8)153 (18.6)466 (22.4)Etanercept30 (46.2)154 (45.8)229 (26.7)54 (6.6)467 (22.4)İnfliximab20 (30.8)58 (17.3)64 (7.5)7 (0.9)149 (7.1)Golimumab0037 (4.3)43 (5.2)80 (3.8)Certolizumab0037 (4.3)68 (8.3)105 (5.0)Anti-TNF65 (100)323 (96.4)554 (64.5)325 (39.5)1267 (60.9)Tofacitinib006 (0.7)212 (25.8)218 (10.5)Tocilizumab009 (1.0)102 (12.4)111 (5.3)Rituximab012 (3.6)136 (15.8)84 (10.2)232 (11.1)Abatacept00153 (17.8)99 (12.0)252 (12.1)Non-Anti-TNF012 (3.6)304 (35.5)497 (60.5)813 (39.1)Total65 (100)335 (100)858 (100)822 (100)2080 (100)Approval years of drugs in Turkey; Infliximab: 2003, etanercept:2004, adalimumab: 2005, golimumab: 2013, certolizumab: 2014, abatacept: 2010, tocilizumab: 2013, rituximab:2009, tofacitinib: 2015,Conclusion:Real-life practice in RA seems consistent with treatment guidelines. Use of non-Anti-TNF bDMARDs becoming more frequent year-by-year. Jak kinase inhibitor has rised through the last 5 years. Next decade may be the years of Jak kinases inhibitors.Disclosure of Interests:None declared
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Karloh, Manuela, Simone Aparecida Vieira Rocha, Marcia Margaret Menezes Pizzichini, Francine Cavalli, Darlan Laurício Matte, and Emilio Pizzichini. "Is the COPD Assessment Test sensitive for differentiating COPD patients from active smokers and nonsmokers without lung function impairment? A population-based study." Jornal Brasileiro de Pneumologia 44, no. 3 (May 2018): 213–19. http://dx.doi.org/10.1590/s1806-37562017000000149.
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ABSTRACT Objective: To assess COPD Assessment Test (CAT) scores in adults with and without COPD, as well as to compare the CAT scores for nonsmokers, former smokers, and smokers without COPD with those for patients with COPD. Methods: This was a cross-sectional population-based study (the Respira Floripa study). The study included adults ≥ 40 years of age residing in the city of Florianópolis, Brazil. A total of 846 households were surveyed. In addition to completing the Respira Floripa questionnaire and the CAT, participants underwent pulmonary function testing. Results: We analyzed data on 1,057 participants (88.1% of the predicted sample size). A functional diagnosis of COPD was made in 92 participants (8.7%). Of those, 72% were unaware that they had COPD. The mean CAT score was higher in the group of COPD patients than in that of individuals without COPD (10.6 [95% CI: 8.8-12.4] vs. 6.6 [95% CI: 6.1-7.0]; p < 0.01). Individual item scores were significantly higher in the patients with COPD than in the individuals without COPD (p < 0.001), the exception being the scores for the items related to sleep (p = 0.13) and energy (p = 0.08). The mean CAT score was higher in the group of COPD patients than in nonsmokers (5.8 [95% CI: 5.3-6.4]) and former smokers (6.4 [95% CI: 5.6-7.2]; p < 0.05). However, there were no significant differences in the mean CAT score between the group of COPD patients and smokers without COPD (9.5 [95% CI: 8.2-10.8]; p > 0.05), the exception being the mean scores for confidence leaving home (p = 0.02). Conclusions: CAT scores were higher in the group of patients with COPD than in nonsmokers and former smokers without COPD. However, there were no significant differences in CAT scores between COPD patients and smokers without COPD. Smokers with an FEV1/FVC ratio > 0.70 have impaired health status and respiratory symptoms similar to those observed in COPD patients.
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Bestiantono, Della Shinta. "Students’ Responses toward Scientific Argumentation with ADI Learning Model to Physics Literacy: A Case of Indonesian Senior High School Students." Studies in Learning and Teaching 1, no. 1 (April 13, 2020): 3–11. http://dx.doi.org/10.46627/silet.v1i1.18.
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The aim of this study is to explore Indonesian students’ responses towards scientific argumentation with ADI learning model to physics literacy by using survey study. The sample included 100 Indonesian senior high school students (47% male and 53% female) who were studying at public school in East Java province. The Responses towards Scientific Argumentation ADI Learning Model to Physics Literacy (RT-SAPL) questionnaire was developed with Indonesian language and validated through an exploratory factor analysis of participants’ responses. For measuring the correlation among three dimensions of scale, the Pearson Correlation product moment was used. The findings indicated: the instrument used in this study had satisfactory validity and reliability. Meanwhile, the construct validities of the RT-SAPL were varying from .617 and .832 and extracting 70.655% of the variance with overall Cronbach’s alpha constant was .854. Moreover, the dimension of ADI learning model came in the first rank and followed by Scientific argumentation as well as the degree of responses towards scientific argumentation with ADI learning model to physics literacy. Finally, the findings have also indicated a significant relationship among factors of RT-SAPL.
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Karagianni, Konstantina, Olyvia Donti, Christos Katsikas, and Gregory C. Bogdanis. "Effects of Supplementary Strength–Power Training on Neuromuscular Performance in Young Female Athletes." Sports 8, no. 8 (July 24, 2020): 104. http://dx.doi.org/10.3390/sports8080104.
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This study examined the effects of a short-duration supplementary strength–power training program on neuromuscular performance and sport-specific skills in adolescent athletes. Twenty-three female “Gymnastics for All” athletes, aged 13 ± 2 years, were divided into a training group (TG, n = 12) and a control group (CG, n = 11). Both groups underwent a test battery before and after 10 weeks of intervention. TG completed, in addition to gymnastics training, a supplementary 7–9 min program that included two rounds of strength and power exercises for arms, torso, and legs, executed in a circuit fashion with 1 min rest between rounds, three times per week. Initially, six exercises were performed (15 s work–15 s rest), while the number of exercises was decreased to four and the duration of each exercise was increased to 30 s (30 s rest) after the fifth week. TG improved countermovement jump performance with one leg (11.5% ± 10.4%, p = 0.002) and two legs (8.2% ± 8.8%, p = 0.004), drop jump performance (14.4% ± 12.6%, p = 0.038), single-leg jumping agility (13.6% ± 5.2%, p = 0.001), and sport-specific performance (8.8% ± 7.4%, p = 0.004), but not 10 m sprint performance (2.4% ± 6.6%, p = 0.709). No change was observed in the CG (p = 0.41 to 0.97). The results of this study indicated that this supplementary strength–power program performed for 7–9 min improves neuromuscular and sport-specific performance after 10 weeks of training.
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León Gross, Teodoro, and Elena Blanco Castilla. "Identidad editorial en la prensa nacional española: interrelación con la agenda mediática." Revista Latina de Comunicación Social, no. 64 (August 15, 2009): 602–11. http://dx.doi.org/10.4185/10.4185/rlcs-64-2009-848-602-611.
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La definición de la identidad de la prensa nacional requiere la evaluación de la sección editorial y, como se aborda aquí a partir de una metodología cuantitativa, la vinculación de ésta con los contenidos informativos. El análisis constata que existe una fuerte relación (4 de cada 5 editoriales conectan con una información del día) y además con relieve al deducirse porcentajes significativos de esa información de referencia en portada o primera página de sección, así como coberturas de tamaño considerable con promedios superiores a dos páginas. Este fenómeno apunta a una atenuación del modelo doctrinal de prensa.
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Hassan Abdelilah, Tafenzi, Farah Choulli, Ismail Essadi, and Rhizlane Belbaraka. "Investigating the outcome of vascular emboli in patients with breast cancer." Journal of Clinical Oncology 42, no. 16_suppl (June 1, 2024): e13116-e13116. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e13116.
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e13116 Background: Vascular emboli (VE) represent a critical event in breast cancer pathophysiology. Despite their clinical relevance, their relative impact on breast cancer outcomes remains underexplored. In this study, we delve into comparing the survival outcomes and recurrence rates of patients with and without VE in patients with breast cancer (BC) and adjust for other patient-related variables. Methods: This study was designed based on a retrospective cohort of pathologically confirmed de novo, local, or metastatic recurrence BC female patients diagnosed between 2020 and 2022 and aged > 18 years. Kaplan-Meier curves and Cox proportional hazards models were used to estimate the effect of vascular emboli on survival and recurrence while controlling other reviewed demographic, clinic, pathologic, and therapeutic features following a course of adjuvant or neo-adjuvant treatments. Results: A total of 501 patients were eligible for this study (216 patients without VE vs. 285 patients with VE). The median follow-up was 274 (IQR: 195–523) days. In the group of patients with positive VE, the median age at diagnosis was 49 years, and the median progression-free survival (mPFS) was 881 (95% CI: 856, 1555) days; Patients with bilateral BC have a poorer mPFS of 515 (95% CI: 411, Not Estimable [NE]), while right BC was associated with a better outcome of 1,035 (95% CI: 869, NE) days (p = 0.001). Moreover, patients with positive hormonal receptors (HR >=10%) who benefited from endocrine therapies have a better PFS of 974 (95% CI: 872, NE) days compared to those with negative HR (<10%) of 656 (95% CI: 586, NE) days (p = 0.02). In addition to the molecular profile, TNBC was associated with poorer survival 579 (95% CI: 553, NE), compared to RH-/HER2+ 675 (95% CI: 635, NE), RH+/HER2- 935 (95% CI: 777, NE), and RH+/HER2+ 1,133 (95% CI: 856, NE) days (p < 0.001). Surgery was associated with better mPFS (935 (95% CI: 869, NE) days compared to neo-adjuvant or palliative patients 856 (95% CI: 635, NE) (p = 0.002). In the group of patients with negative VE, the median age was 48 years. The mPFS was 852 (95% CI: 789–996) days. Patients presented with positive lymph (N2) have a worse PFS of 611 (95% CI: 505, NE) days; in addition, patients with HER2=0 have a worse PFS of 775 (95% CI: 595, 1,320) days compared to HER2 1+ or non-amplified HER2 2+ 928 (95% CI: 840, NE) days, while no statistically significant differences between patients who received different treatment options (HER2 TKI, chemotherapy, radiotherapy, and endocrine therapy) were found. Conclusions: These findings emphasize the importance of considering VE status and hormonal receptor expression in tailoring treatment strategies for BC patients. Identifying high-risk individuals who may benefit from aggressive or novel therapies remains crucial for improving outcomes. Further research is warranted to validate these results and guide clinical decision-making.
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Simonson, Gregg D., Richard M. Bergenstal, Mary L. Johnson, Janet L. Davidson, and Thomas W. Martens. "Effect of Professional CGM (pCGM) on Glucose Management in Type 2 Diabetes Patients in Primary Care." Journal of Diabetes Science and Technology 15, no. 3 (March 10, 2021): 539–45. http://dx.doi.org/10.1177/1932296821998724.
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Background: Little data exists regarding the impact of continuous glucose monitoring (CGM) in the primary care management of type 2 diabetes (T2D). We initiated a quality improvement (QI) project in a large healthcare system to determine the effect of professional CGM (pCGM) on glucose management. We evaluated both an MD and RN/Certified Diabetes Care and Education Specialist (CDCES) Care Model. Methods: Participants with T2D for >1 yr., A1C ≥7.0% to <11.0%, managed with any T2D regimen and willing to use pCGM were included. Baseline A1C was collected and participants wore a pCGM (Libre Pro) for up to 2 weeks, followed by a visit with an MD or RN/CDCES to review CGM data including Ambulatory Glucose Profile (AGP) Report. Shared-decision making was used to modify lifestyle and medications. Clinic follow-up in 3 to 6 months included an A1C and, in a subset, a repeat pCGM. Results: Sixty-eight participants average age 61.6 years, average duration of T2D 15 years, mean A1C 8.8%, were identified. Pre to post pCGM lowered A1C from 8.8% ± 1.2% to 8.2% ± 1.3% (n=68, P=0.006). The time in range (TIR) and time in hyperglycemia improved along with more hypoglycemia in the subset of 37 participants who wore a second pCGM. Glycemic improvement was due to lifestyle counseling (68% of participants) and intensification of therapy (65% of participants), rather than addition of medications. Conclusions: Using pCGM in primary care, with an MD or RN/CDCES Care Model, is effective at lowering A1C, increasing TIR and reducing time in hyperglycemia without necessarily requiring additional medications.
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Gounaridi, Maria Ioanna, Angelos Vontetsianos, Evangelos Oikonomou, Panagiotis Theofilis, Nikolaos Chynkiamis, Stamatios Lampsas, Artemis Anastasiou, et al. "The Role of Rehabilitation in Arterial Function Properties of Convalescent COVID-19 Patients." Journal of Clinical Medicine 12, no. 6 (March 13, 2023): 2233. http://dx.doi.org/10.3390/jcm12062233.
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Coronavirus disease (COVID-19) is a respiratory disease, although arterial function involvement has been documented. We assess the impact of a post-acute COVID-19 rehabilitation program on endothelium-dependent vasodilation and arterial wall properties. We enrolled 60 convalescent patients from COVID-19 and one-month post-acute disease, who were randomized at a 1:1 ratio in a 3-month cardiopulmonary rehabilitation program (study group) or not (control group). Endothelium-dependent vasodilation was evaluated by flow-mediated dilation (FMD), and arterial wall properties were evaluated by carotid–femoral pulse wave velocity (cf-PWV) and augmentation index (AIx) at 1 month and at 4 months post-acute disease. FMD was significantly improved in both the study (6.2 ± 1.8% vs. 8.6 ± 2.4%, p < 0.001) and control groups (5.9 ± 2.2% vs. 6.6 ± 1.8%, p = 0.009), but the improvement was significantly higher in the study group (rehabilitation) (p < 0.001). PWV was improved in the study group (8.2 ± 1.3 m/s vs. 6.6 ± 1.0 m/s, p < 0.001) but not in the control group (8.9 ± 1.8 m/s vs. 8.8 ± 1.9 m/s, p = 0.74). Similarly, AIx was improved in the study group (25.9 ± 9.8% vs. 21.1 ± 9.3%, p < 0.001) but not in the control group (27.6 ± 9.2% vs. 26.2 ± 9.8 m/s, p = 0.15). Convalescent COVID-19 subjects of the study group (rehabilitation) with increased serum levels of circulating IL-6 had a greater reduction in FMD. Conclusively, a 3-month cardiopulmonary post-acute COVID-19 rehabilitation program improves recovery of endothelium-dependent vasodilation and arteriosclerosis.
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Perondi, Paula Roberta, Pedro Henrique Cabral Oliveira, Alessandra Cassoni, André Figueiredo Reis, and José Augusto Rodrigues. "Ultimate tensile strength and microhardness of glass ionomer materials." Brazilian Dental Science 17, no. 1 (January 24, 2014): 16. http://dx.doi.org/10.14295/bds.2014.v17i1.949.
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<p><strong>Objective:</strong> This study evaluated the ultimate tensile strength (UTS) and microhardness (µKH) of conventional (CO) and hybrid resin-modified glass ionomer (RM). <strong>Material and methods:</strong> Nine specimens to UTS and twelve for µKHN of glass ionomer materials were obtained using special molds. The materials were manipulated and CO groups were allowed to self-cure for five minutes and RM were subjected to light-activation as indicated by manufactures through a glass slide. All specimens were dark-stored in 100% relative humidity for 24h. For UTS test, specimens were tested in tension in a universal testing machine (crosshead speed of 1 mm/min) until failure. For µKHN test a Knoop diamond indenter was used to make five indentations in the upper/light irradiated surface of the specimens. UTS and µKHN data were submitted to one-way ANOVA, followed by Tukey’s test (α= 5%). <strong>Results:</strong> The results for UTS were: Ionomaster: 7.0 (±1.6)A; Maxxion R: 8.8 (±3.7)A Vidrion R: 8.8 (±3.9)A; ChemFil Rock: 10.7 (±4.6)AB; Vitremer: 13.1 (±3.3)BC; Vitrofil R: 14.9 (±7.8)CD; Ionoseal: 14.5 (±8.2)CD; Resiglass: 16.3 (±2.3)D. The results for µKH: Ionomaster: 24.3 (±6.6)B; Maxxion R: 17.7 (±4.7)A, Vidrion R: 31.0 (±9.4) B; ChemFil Rock: 31.1 (±8.5)B; Vitremer: 20.3 (±3.3)A; Vitrofil R: 16.5 (±5.1)A; Ionoseal: 13.1 (±8.5)A; Resiglass: 21.6 (±5.2)A. <strong>Conclusion:</strong> It was observed that the hybrid resin-modified ionomers generally have higher cohesive strength than conventional ones, but lower microhardness.</p>
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Kwak, Jae-Yong, Na-Ri Lee, Eun-Kee Song, Chang-Yeol Yim, and Yong-Geun Kwak. "The Comparative Analysis of Serum Proteomes for the Discovery of Biomarkers for Essential Thrombocythemia." Blood 106, no. 11 (November 16, 2005): 4004. http://dx.doi.org/10.1182/blood.v106.11.4004.4004.
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Abstract Background: Essential thrombocythemia(ET) is a clonal disorder involving a hematopoietic progenitor cell and is manifested by the overproduction of platelets. There is as yet no pathognomonic diagnostic test. In our study, to identify the biomarkers for an initial diagnosis by a lesser invasive method, serum proteins reflecting alteration their proteomes were analysed. Methods: We compared two-dimensional electrophoresis patterns of human sera of twelve patients with ET with that of normal twelve subjects. The differentially expressed spots were identified by matrix-assisted laser desorption/ionization-time-of flight(MALDI-TOF) and electrospray ionization quadupole time of flight(ESI-Q-TOF)mass spectrometry. Results: Twenty two spots that expressed differentially in ET group were found. The expression levels of fibrinogen γ, fibrinogen γ-A chain precursor, ALB protein, α-2 macroglobulin, H factor-1, α-2-macroglobulin precursor, ceruloplasmin, α-1-B-glycoprotein, α-2-plasmin inhibitor, α-1-B-glycoprotein and an unknown protein were up-regulated in serum of ET patients, whereas the other proteins including complement fator B preproprotein, afamin precursor, inter-α inhibitor H4, immunoglobulin heavy chain constant region γ 1, immunoglobulin κ light chain and an unknown protein down-regulated. Conclusion: These results suggest that these proteins can be used as less invasive diagnostic and follow-up biomarkers of ET if further studies were done. The proteins significantly changed in sera of ET Spot no. Name Accession no. % coverage Mw(KDa)/pI(Measured) Mw(KDa)/pI(database) ET(%) 67 fibrinogen γ 223170 39 50.57/5.6 46.82/5.5 2.54±0.52 69 ” 223170 33 50.57/5.6 46.83/5.5 3.93±1.19 73 fibrinogen γ-A chain precursor 71827 23 48.93/5.6 50.11/5.7 3.89±0.98 74 ” 71827 22 48.93/5.8 50.11/5.7 3.10±0.91 77 ALB protein 27692693 21 50.57/5.9 48.65/6.0 3.77±0.58 89 α-2-macroglobulin 177872 14 263.89/6.1 71.35/5.5 1.95±0.32 100 H factor 1 4504875 20 248.95/5.7 143.79/6.3 5.8±1.78 112 α-2-macroglobulin precursor 4557225 9 151.38/5.7 164.69/6.0 2.18±0.38 125 complement factor B preproprotein 4502397 14 151.38/5.7 86.86/6.6 0.49±0.07 138 afamin precursor 4501987 12 65.01/5.1 85.53/6.3 0.31±0.07 139 ” 4501987 12 65.01/5.1 85.53/6.3 0.36±0.09 140 inter- α inhibitor H4 31542984 12 93.33/5.3 103.57/6.5 0.36±0.08 154 ceruloplasmin 4557485 8 132.89/5.3 123.04/5.4 3.34±0.80 161 α-1-B-glycoprotein 69990 21 84.50/5.0 52.49/5.6 4.23±0.98 162 α-2-plasmin inhibitor 11386143 14 78.58/5.0 54.92/5.8 1.95±0.38 167 α-1-B-glycoprotein 69990 28 80.87/5.3 52.49/5.6 1.73±0.04 210 Not identified - - 38.47/4.6 - 2.77±0.20 249 immunoglobulin heavy chain constant regionγ 1 12054072 15 39.021/8.1 36.65/8.8 0.40±0.09 250 ” 12054072 18 38.79/8.2 36.65/8.8 0.34±0.14 252 ” 12054072 19 38.50/8.3 36.65/8.8 0.37±0.09 262 unknown 15679996 36 24.73/8.2 23.32/8.6 0.30±0.13 265 immunoglobulinκ light chain 2765423 22 25.75/8.8 25.93/9.2 0.28±0.12 Figure Figure
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Chang, Chao-Jui, Chih-Kai Hong, and Che-Chia Hsu. "“Double Cross Sign” Could Be an Indicator of an Adequate Amount of Bone Cement in Kyphoplasty with the SpineJack System: A Retrospective Study." Diagnostics 12, no. 12 (December 6, 2022): 3068. http://dx.doi.org/10.3390/diagnostics12123068.
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Kyphoplasty with the SpineJack system was able to restore vertebral height and stabilize the vertebra with an injection of bone cement. The goal of this study was to seek a reliable assessing method during the surgery in determining the minimum amount of bone cement required for the SpineJack system to restore vertebral height and stabilize the vertebra. We defined the “double cross sign” as bone cement that expanded vertically along the bilateral SpineJack system, and spread across the midline of the vertebral body as viewed in the anteroposterior (AP) view of the radiographic image. Sixty-five patients aged 74.5 ± 8.5 years with vertebral compression fracture were included in the study. Patients with a positive double cross sign had better ODI score than those without the double cross sign (20.0 ± 6.9 vs. 32.3 ± 8.2; p < 0.001). Postoperative regional kyphotic and local kyphotic angle were significantly better in the positive double cross sign group (11 ± 8.8 degrees vs. 5.3 ± 3.2 degrees; p = 0.001/11.7 ± 6.2 degrees vs. 6.6 ± 4.1 degrees; p = 0.001, respectively). The more stable construct was built once the double cross sign was achieved during surgery. In this study, a convenient and intuitive method in identifying the minimum but sufficient quantity of injected cement during the SpineJack procedure was developed.
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Al-Jaber, Noor-Aldeen, Ahmed A. K. Thabet, Manal Al-Hakeem, Manae Al-Arashi, Abdulhakim Sharaf, and Essam Al-Safadi. "Transesophageal Echocardiograph Findings in Patients with Cardiovascular Disorders at Al-Thawrah General Hospital, Sana’a, Yemen." Yemeni Journal for Medical Sciences 9, no. 1 (December 17, 2015): 6–13. http://dx.doi.org/10.20428/yjms.v9i1.524.
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ABSTRACT Objectives: To determine the frequency distribution of different cardiovascular disorders and to describe their associated morphological abnormalities by transesophageal echocardiography among patients referred to the Transesophageal Echocardiography Laboratory of Al-Thawrah General Hospital, Sana’a, in the period 2009– 2011. Methods: This was a retrospective descriptive study of 856 patients with suspected cardiovascular disorders and referred for transesophageal echocardiography over a two-year period. Data about patients’ sex, their refer- ral site and transesophageal echocardiography findings were collected and analyzed according to the type of cardiovascular disorders, valvular affections and lesions, complications and recommended treatments. Results: Of the 856 patients, 63.4% were females and 36.6% were males. The majority of patients diagnosed by transesophageal echocardiography (82.4%) were referred from outpatient departments. Rheumatic heart dis- ease was the most frequent cardiovascular disorder (87.1%), followed by tricuspid valve lesions (62.8%), of which 54% (329/606) were tricuspid regurgitation and 62.6% (114/182) were aortic valve regurgitation. Re- garding the type of valvular lesions detected, mitral valve disease was the most frequent, being found in 69.2% (214/309) of patients. Regarding the severity of valvular lesions, 73.1% (19/26) of mitral valve stenosis cases were severe while 83.3% (35/62) of aortic stenosis cases were mild. Moderate pulmonary hypertension was seen mostly secondary to rheumatic heart disease. The majority of cardiovascular disorder patients (33.6%; 284/844) were recommended for balloon mitral valvotomy. Mitral valve surgery was the most frequently per- formed surgical intervention for affected valves of patients with cardiovascular disorders; being used for the treatment of 31.4% (80/255) of valvular lesions. Conclusions: Transesophageal echocardiography revealed that rheumatic heart disease is the most frequent cardiovascular disorder among Yemeni patients and poses a major health problem. In addition, a high propor- tion of patients with cardiovascular disorders have valvular lesions of the mild degree that require surgical in- tervention.
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Zhoukovskaya, I. G., and I. R. Yakupova. "Effect of vitamin D on women’s somatic and reproductive health." Medical Council, no. 21 (January 28, 2020): 268–73. http://dx.doi.org/10.21518/2079-701x-2019-21-268-273.
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The article presents the results of a study of the effect of vitamin D deficiency on women’s health.The study aimed to determine the prevalence of vitamin D deficiency and its relationship with the somatic and reproductive health of women.Methods: observation group I included 31 women with a reduced serum vitamin D levels (20.4 ± 1.0 ng/ml), comparison group II included 31 patients with normal vitamin D levels (39.0 ± 1.4 ng/ml). Results: the negative effect of vitamin D deficiency on women’s health is also practically assured, i.e. the incidence of somatic pathology is significantly higher in group I compared with group II: obesity (62.5 ± 12.1% and 18.8 ± 9.8%; p <0.5), insulin resistance (55.0 ± 9.0% and 1.0 ± 6.0%; p <0.001); arterial hypertension (42.0 ± 8.8% and 13.0 ± 6.0%; p <0.01); hypertrophic myocardiopathy (25.8 ± 7.8% and 6.4 ± 4.4%; p <0.05); chronic colitis (29.0 ± 8.1% and 6.4 ± 4.4%; p <0.05), gastric ulcer (22.5 ± 7.5% and 3.2 ± 3.2%; p <0.05), chronic pancreatitis (22.5 ± 7.5% and 3.2 ± 3.2%; p <0.05), chronic gastritis (25.8 ± 7.8% and 9.7 ± 5.3%; p <0.1). The interaction between reduced vitamin D levels and reproductive system diseases is confirmed by significant increase in the prevalence of secondary amenorrhea (80.0 ± 9.0% and 16.0 ± 7.3%; p <0.001), secondary oligomenorrhea (75.0 ± 9.7% and 20.0 ± 8.0%; p <0.001), hyperplastic processes – uterine fibroids (48.4 ± 9.0% and 13.3 ± 6.1%; p <0.001) and adenomyosis (26.6 ± 7.9% and 6.7 ± 4.5%; p <0.05), polycystic ovary syndrome (29.0 ± 8.2% and 6.7 ± 4.5%; p <0.05), vaginal microbiocenosis disorders (aerobic vaginitis – 42.0 ± 8.9% and 16.1 ± 6.6%; p <0.05; bacterial vaginosis – 29.0 ± 8.2% and 9.7 ± 5.3%; p <0.05).Conclusion: management of vitamin D level is one of the priorities in the formation of therapeutic and preventive measures to improve the women’s health.
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Reid, Alison, Alison Daly, and Marc Schenker. "O4C.2 Impact of precarious work on the wellbeing of women and migrants in australia." Occupational and Environmental Medicine 76, Suppl 1 (April 2019): A36.2—A36. http://dx.doi.org/10.1136/oem-2019-epi.98.
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IntroductionWomen and migrants are more likely to be in precarious work than men and native-born workers. Precarious work impacts adversely on work-related injuries, fatalities and health but little is known about how it affects the wellbeing of women and migrant workers. The aims of this study are; (1) to examine whether precarious work differs by migration status and sex and 2) to determine whether the impact of precarious work on the wellbeing of women and migrants differs to that of males and native-born workers.MethodsIn 2016/17 a national telephone survey examined psychosocial workplace hazards among 1630 migrant and 1051 Australian-born workers. Precarious work (vulnerability and job insecurity) and wellbeing were collected with sociodemographic and employment variables. Higher scores indicate greater vulnerability/insecurity/less wellbeing. Univariate statistics examined the association between precarious work and wellbeing by sex and country of birth. Stratified linear regression modelled the relationship between precarious work and wellbeing by sex.ResultsIndependent of country of birth, females had higher vulnerability (µ=6.5, σ=3.4) than males (µ=5.5, σ=3.6), in contrast to job insecurity (Women µ=8.2, σ=4.0; Men µ=8.2, σ=3.9). Workers born in the Philippines had higher vulnerability compared with other migrant workers (µ=6.6, σ=3.4 vs µ=5.9, σ=3.6) whereas workers born in India had higher employment insecurity compared with other migrant workers (µ=8.8, σ=4.1 vs µ=8.1, σ=3.9). Increasing vulnerability and insecurity adversely impacted wellbeing most in Australian workers. Compared with men, vulnerability had a greater adverse impact on the wellbeing of women.DiscussionTwo dimensions of precarious work impact the wellbeing of men and women differently. Vulnerability impacts women most whereas work insecurity impacts men. For Australian born, the impact of either dimension on wellbeing is greater than for migrant workers.
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Mahano, Aladin Ombeni, Neveen Fahmy Agamy, Doaa Tawfik Mohamed, Salma Adnan Bekhit, and Mahmoud Mohamed El Tawila. "Dietary exposure to aflatoxin B1 and ethanol from homemade and industrial fermented beverages in South Kivu, Democratic Republic of the Congo." Open Access Macedonian Journal of Medical Sciences 12 (March 20, 2024): 1–9. http://dx.doi.org/10.3889/oamjms.2024.11839.
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BACKGROUND: The prevalence of AFB1 contamination in agricultural products used to produce fermented alcoholic beverages is increasing, raising concerns for human health. AIM: The aim of this study was to investigate dietary exposure to AFB1 and ethanol through homemade and industrial fermented beverages commonly consumed in South Kivu, DR Congo. METHOD: AFB1 and ethanol were measured using reverse-phase HPLC with a fluorescence detector and a refractive index detector, respectively. Data on fermented beverage consumption were collected from 847 adults using a food frequency questionnaire (FFQ). RESULTS: The findings revealed that industrial sample Man 8 had the highest exposure to AFB1 (77.8 ± 45.0 ng/kg b.w/day) and Man4 had the highest ethanol exposure (4.83 ± 2.40 mg/kg b.w/day); while among homemade samples, Kasiksi had the highest exposure to both AFB1 (8.8 ± 6.6 ng/kg b.w/day) and ethanol (2.46 ± 1.85 mg/kg b.w/day). The margin of exposure (MOE) for AFB1 was 1011.7 or less, and for ethanol, it was 818.2 or less. Men are more likely to be exposed. CONCLUSION: Increased consumption of homemade and industrial fermented beverages raises the risk of developing hepatocellular cancer (HCC) because the levels of AFB1 and ethanol MOE drop below the safe limit of 10000. Further research is needed to investigate the connection between AFB1, ethanol, and HCC, especially in regions where alcohol misuse is common.
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Naqvi, Syed Atif Hasan, Shehzad Iqbal, Hafeez-ur-Rehman Hafeez-ur-Rehman, Umar Farooq, Muhammad Zeeshan Hassan, Muhammad Nadeem Shahid, Adnan Noor Shah, et al. "Evaluation of Bacterial Perpetuation Assays and Plant Biomolecules Antimicrobial Activity against Cotton Blight Bacterium Xanthomonas citri subsp. malvacearum; An Alternative Source for Food Production and Protection." Plants 11, no. 10 (May 10, 2022): 1278. http://dx.doi.org/10.3390/plants11101278.
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Cotton (Gossypium hirsutum) is a global cash crop which has gained importance in earning foreign exchange for each country. Bacterial blight caused by Xanthomonascitri subsp. malvacearum (Xcm) has been a seriousdisease in Pakistan’s cotton belt on multiple occasions. Bacterium was isolated and identified through various biochemical and diagnostic tests wherehypersensitivity reaction, Gram staining, KOH (potassium hydroxide), catalase, starch hydrolysis, lecithinase and Tween 80 hydrolysis tests confirmed bacterium as Gram-negative and plant pathogenic. Xcm perpetuation assays wereevaluated on various cotton varieties under glasshouse conditions in completely randomized design by three different methods, wherein the scratch method proved to be the best upon CIM-496 and showed 83.33% disease incidence as compared with the other two methods, where Bt-3701 responded with 53.33% incidence via the spray gun method, and 50% with the water splash method on CIM-616, as compared with the control. Similarly, for disease severity percentage, Bt-3701 was pragmatic with 47.21% through scratch method, whereas, in the spray gun method, 45.51% disease severity was noted upon Bt-802, and 31.27% was calculated on Cyto-179 through the water splash method. Owing to the unique antibacterial properties of aqueous plant extracts, the poison food technique showed Aloe vera, Mentha piperita, Syzygiumcumini and Azadirachta indica with 17.77, 29.33, 18.33 and 20.22 bacterial colonies counted on nutrient agarmedium petri plate, respectively, as compared with the control. Measurement of the inhibition zone by disk diffusion technique showed Mentha piperita, Syzygiumcumini, Citrus limon, Moringa oleifera and Syzygium aromaticum to present the most promising results by calculating the maximum diameter of the inhibition zone, viz., 8.58, 8.55, 8.52, 8.49 and 8.41 (mm), respectively, at the highest tested concentration (75 ppm, parts per million) compared with the control. It is probable that the decoction’s interaction with the pathogen population on the host plant will need to be considered in future experiments. However, at this moment, more research into the effective management of cotton bacterial blight by plant extracts in terms of concentration determination and development of biopesticides will provide future avenues to avoid environmental pollution.
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Rusdi, Ahmad, Rumiani Rumiani, Nyda Afsari, and Rena Latifa. "Measuring Peace of Heart: The Development and Validation of Taṭmainn al-Qulūb Scale (TQS)." JP3I (Jurnal Pengukuran Psikologi dan Pendidikan Indonesia) 11, no. 1 (May 19, 2022): 64–83. http://dx.doi.org/10.15408/jp3i.v11i1.23661.
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Peace of heart is an inner spiritual experience that generates an emotional feeling of harmony. Peace of heart (taṭmainn al-qulūb) is an important aspect applicable for the life of the Muslim community as a treatment for the psychological problems of the modern era, mainly due to the absence of peace. Thus far, no research has been done on the development of peace of heart to capture the uniqueness, specific aspect, and distinctive aspect of peace in Muslim community. A total of 744 respondents responded to this research. Six experts were involved to examine item wording in this research (CVR= .67-1.00). This study has found that the TQS consists of two components (al-sukūn and al-yaqīn) with a good loading factor (.687-.884), Cronbach's Alpha (.844), and item consistency (.545-.857). All items had a good difficulty level and appropriate rating. Convergence validity on this scale was indicated by its correlation with The Brief Serenity Scale (r= .612). The criterion-related validity on this scale was indicated by its correlation with dhikr quality (r= .629), Islamic positive religious coping (r= .518), perceived stress (r= -.453), and sensibility (r= .103). Further studies need to be done based on the followings: 1) Examining the measurement on this topic with larger respondents having equal variance; 2) Considering gender, education level, and age in norming study of this scale; 3) Validating with other measurements to add validity information, especially discriminant validity
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Evans, Avery J., Kevin E. Kip, Waleed Brinjikji, Kennith F. Layton, Mary L. Jensen, John R. Gaughen, and David F. Kallmes. "Randomized controlled trial of vertebroplasty versus kyphoplasty in the treatment of vertebral compression fractures." Journal of NeuroInterventional Surgery 8, no. 7 (June 24, 2015): 756–63. http://dx.doi.org/10.1136/neurintsurg-2015-011811.
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BackgroundWe present the results of a randomized controlled trial evaluating the efficacy of vertebroplasty versus kyphoplasty in treating vertebral body compression fractures.MethodsPatients with vertebral body compression fractures were randomly assigned to treatment with kyphoplasty or vertebroplasty. Primary endpoints were pain (0–10 scale) and disability assessed using the Roland–Morris Disability Questionnaire (RMDQ). Outcomes were assessed at 3 days, 1 month, 6 months, and 1 year following the procedure.Results115 subjects were enrolled in the trial with 59 (51.3%) randomly assigned to kyphoplasty and 56 (48.7%) assigned to vertebroplasty. Mean (SD) pain scores at baseline, 3 days, 30 days, and 1 year for kyphoplasty versus vertebroplasty were 7.4 (1.9) vs 7.9 (2.0), 4.1 (2.8) vs 3.7 (3.0), 3.4 (2.5) vs 3.6 (2.9), and 3.0 (2.8) vs 2.3 (2.6), respectively (p>0.05 at all time points). Mean (SD) RMDQ scores at baseline, 3 days, 30 days, 180 days, and 1 year were 17.3 (6.6) vs 16.3 (7.4), 11.8 (7.9) vs 10.9 (8.2), 8.6 (7.2) vs 8.8 (8.5), 7.9 (7.4) vs 7.3 (7.7), 7.5 (7.2) vs 6.7 (8.0), respectively (p>0.05 at all time points). For baseline to 12-month assessment in average pain and RMDQ scores, the standardized effect size between kyphoplasty and vertebroplasty was small at −0.36 (95% CI −1.02 to 0.31) and −0.04 (95% CI −1.68 to 1.60), respectively.ConclusionsOur study indicates that vertebroplasty and kyphoplasty appear to be equally effective in substantially reducing pain and disability in patients with vertebral body compression fractures.Trial registration numberNCT00279877.
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Ruffo, Robert, Erin Shufflebarger, James Booth, and Lauren Walter. "Race and Other Disparate Demographic Variables Identified Among Emergency Department Boarders." Western Journal of Emergency Medicine 23, no. 5 (August 28, 2022): 644–49. http://dx.doi.org/10.5811/westjem.2022.5.55703.
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Introduction: Emergency department (ED) boarding, the process of holding patients in the ED due to a lack of inpatient beds after the decision is made to admit, has profound consequences. Increased ED boarding times are associated with adverse patient outcomes, including increased mortality. While previous studies have demonstrated racial disparities with regard to ED boarding, current literature lacks insight into discrepancies that may exist among other demographic groups as it pertains to ED boarding. We sought to review ED boarding times differentiated by demographic characteristics. Methods: We conducted a retrospective review of all ED admissions from an academic ED in the Southeast from April–September 2019. The primary outcome assessed was boarding time, defined as time from decision to admit to ED departure. Patient demographic data including race, gender, and age were collected and analyzed. We performed descriptive statistics and chi-square analyses. Results: The study population included 17,606 patients with a mean age of 56.3. Nearly half (49.8%) of the patients were female. Additionally, 43.8% of patients were Black and 48.6% White. For all admissions, there was no difference in mean boarding time among Black and White patients (5.2 ± 8.8 vs 5.2 ± 8.2 hours, P = 0.11). Among Emergency Severity Index (ESI) level I admissions, Black patients boarded longer than White patients (4.1 ± 0.3 vs 2.7 ± 0.3 hours, P = 0.009). Black patients also boarded significantly longer than White patients for psychiatric admissions (22.7 ± 23.7 vs 18.5 ± 19.4 hours, P <0.05). For all admissions, males boarded longer than females (5.5 ± 8.5 vs 4.9 ± 8.2 hours, P <.0001). Patients older than 75 boarded for less time (3.8 ± 6.2 hours) compared to younger groups (15-24: 6.4 ± 10.8 hours; 25-44: 6.6 ± 10.8; 45-64: 5.0 ± 7.6; and 64-75: 4.7 ± 6.7; all P <.05). Conclusion: This analysis demonstrated significant differences in ED boarding times between races among psychiatric and ESI I admissions, gender, and age. This data provides insight into differences in ED boarding times among demographic groups and provides a focal point for examining possible factors contributing to the observed differences.
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Crowther, Caroline A., Pat Ashwood, Philippa F. Middleton, Andrew McPhee, Thach Tran, Jane E. Harding, Jane Alsweiler, et al. "Prenatal Intravenous Magnesium at 30-34 Weeks’ Gestation and Neurodevelopmental Outcomes in Offspring." JAMA 330, no. 7 (August 15, 2023): 603. http://dx.doi.org/10.1001/jama.2023.12357.
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ImportanceIntravenous magnesium sulfate administered to pregnant individuals before birth at less than 30 weeks’ gestation reduces the risk of death and cerebral palsy in their children. The effects at later gestational ages are unclear.ObjectiveTo determine whether administration of magnesium sulfate at 30 to 34 weeks’ gestation reduces death or cerebral palsy at 2 years.Design, Setting, and ParticipantsThis randomized clinical trial enrolled pregnant individuals expected to deliver at 30 to 34 weeks’ gestation and was conducted at 24 Australian and New Zealand hospitals between January 2012 and April 2018.InterventionIntravenous magnesium sulfate (4 g) was compared with placebo.Main Outcomes and MeasuresThe primary outcome was death (stillbirth, death of a live-born infant before hospital discharge, or death after hospital discharge before 2 years’ corrected age) or cerebral palsy (loss of motor function and abnormalities of muscle tone and power assessed by a pediatrician) at 2 years’ corrected age. There were 36 secondary outcomes that assessed the health of the pregnant individual, infant, and child.ResultsOf the 1433 pregnant individuals enrolled (mean age, 30.6 [SD, 6.6] years; 46 [3.2%] self-identified as Aboriginal or Torres Strait Islander, 237 [16.5%] as Asian, 82 [5.7%] as Māori, 61 [4.3%] as Pacific, and 966 [67.4%] as White) and their 1679 infants, 1365 (81%) offspring (691 in the magnesium group and 674 in the placebo group) were included in the primary outcome analysis. Death or cerebral palsy at 2 years’ corrected age was not significantly different between the magnesium and placebo groups (3.3% [23 of 691 children] vs 2.7% [18 of 674 children], respectively; risk difference, 0.61% [95% CI, −1.27% to 2.50%]; adjusted relative risk [RR], 1.19 [95% CI, 0.65 to 2.18]). Components of the primary outcome did not differ between groups. Neonates in the magnesium group were less likely to have respiratory distress syndrome vs the placebo group (34% [294 of 858] vs 41% [334 of 821], respectively; adjusted RR, 0.85 [95% CI, 0.76 to 0.95]) and chronic lung disease (5.6% [48 of 858] vs 8.2% [67 of 821]; adjusted RR, 0.69 [95% CI, 0.48 to 0.99]) during the birth hospitalization. No serious adverse events occurred; however, adverse events were more likely in pregnant individuals who received magnesium vs placebo (77% [531 of 690] vs 20% [136 of 667], respectively; adjusted RR, 3.76 [95% CI, 3.22 to 4.39]). Fewer pregnant individuals in the magnesium group had a cesarean delivery vs the placebo group (56% [406 of 729] vs 61% [427 of 704], respectively; adjusted RR, 0.91 [95% CI, 0.84 to 0.99]), although more in the magnesium group had a major postpartum hemorrhage (3.4% [25 of 729] vs 1.7% [12 of 704] in the placebo group; adjusted RR, 1.98 [95% CI, 1.01 to 3.91]).Conclusions and RelevanceAdministration of intravenous magnesium sulfate prior to preterm birth at 30 to 34 weeks’ gestation did not improve child survival free of cerebral palsy at 2 years, although the study had limited power to detect small between-group differences.Trial Registrationanzctr.org.au Identifier: ACTRN12611000491965
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SAARELA, I., A. JÄRVI, and H. HAKKOLA. "Phosphorus status of diverse soils in Finland as influenced by long-term P fertilisation I.Native and previously applied P at 24 experimental sites." Agricultural and Food Science 12, no. 2 (January 2, 2003): 117–32. http://dx.doi.org/10.23986/afsci.5747.
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The native reserves of phosphorus (P) in Finnish soils are sizeable but poorly available to plants. The P status has been generally poor, but large rates of P applied since the 1940s have substantially enhanced the supply of P from the soil. As a means of optimising P fertilisation of crops grown in the improved soils and promoting agro-environmental sustainability of agriculture, long-term field experiments were established in 1977-1981 on various soil types around Finland, between the latitudes of 60 and 65 N. The experimental sites (8 Cambisols, 9 Regosols, 6 Histosols, 1 Podsol) were moderately acidic (pH w 5.6, range 4.6-6.6) and contained 1.6-31.2% organic C, and (mineral soils) 3-74% clay. The concentration of total P was 1.22 (0.66-1.87) g kg -1 , and the inorganic fraction separated with fluoride and hydroxide extractions (Al,Fe-P) was 8.2% (4.5-12.4%) of oxalate extractable Al+Fe (P saturation index). In mineral topsoil the pool of Al,Fe-P was 850 kg ha -1 , which is 300 kg ha -1 larger than was obtained in the early 1960s and 600 kg ha -1 larger than found in virgin soils. The soil test P value was 13.1 (3.7-60) mg dm -3 by the acid ammonium acetate method, 11.5 (1.6-42) mg dm -3 by a water extraction method (1:60 v/v) and 61 (23-131) mg kg -1 with a modified Olsen method. The intensity factor of soil P status has remained at a relatively low level in a major part of the cultivated area.;
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Shehzad, Aamar, Hafeez Ahmad Sadaqat, Mohsin Ali, and Muhammad Furqan Ashraf. "Combining Ability Analysis and Genetic-Effects Studies for Some Important Quality Characters in Brassica napus L." Turkish Journal of Agriculture - Food Science and Technology 3, no. 10 (October 2, 2015): 790. http://dx.doi.org/10.24925/turjaf.v3i10.790-795.463.
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Combining ability analysis has an important position in rapeseed breeding. To evaluate genetic and combining ability effects, three Brassica napus L. testers “Punjab Sarson, Legend and Durre-NIFA” and five lines “Duncled, K-258, ZN-R-1, ZN-R-8, ZN-M-6” were crossed using line × tester design in Randomized Complete Block Design (RCBD) with three replications. Mean sum of squares of the analysis of variances (ANOVA) for genotypes was highly significant for all of the traits. Most of the lines and testers exhibited significant results of mean sum of squares for combining ability. Line ‘Duncled’ was proved good general combiner for oil (8.8), protein (3.7), erucic acid (33.0), oleic acid (13.0) and glucosinolate (-19.3) over other lines and tester ‘Durree-NIFA’ for protein (6.6), erucic acid (-23.4), and linolenic acid (-5.3) over other testers. Significant specific combining ability effects were also observed. The best hybrid combinations were Legend × ZN-R-1 for oil (9.6), Punjab Sarson × Duncled for minimum erucic acid (-14.0) and linolenic acid contents (-6.0), and Legend × ZN-M-6 for maximum protein (8.2) and minimum glucosinolate contents (-11.1). The maximum oil contents were observed in ‘Legend × ZN-R-1’ (52.4%). The cross ‘Punjab Sarson × Duncled’ expressed maximum values of protein (26.5%) and oleic acid (62.5%) while minimum for erucic acid (2.3%), linolenic acid (5.4%) and glucosinolate contents (19.3µmol/g). This research discloses the significance of non-additive genetic effects for most of the studied traits except oil contents. These studies will also help to improve nutritional values of rapeseed crop by selecting noble crosses.
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Nikolajsen, Lone, Nanna B. Finnerup, Steffen Kramp, Anne-Sofie Vimtrup, Johnny Keller, and Troels S. Jensen. "A Randomized Study of the Effects of Gabapentin on Postamputation Pain." Anesthesiology 105, no. 5 (November 1, 2006): 1008–15. http://dx.doi.org/10.1097/00000542-200611000-00023.
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Background Pain after amputation is common but difficult to treat. Therefore, the authors examined whether postoperative treatment with gabapentin could reduce postamputation stump and phantom pain. Methods Forty-six patients scheduled to undergo lower limb amputation were randomly assigned to receive oral gabapentin or placebo. Treatment was started on the first postoperative day and continued for 30 days. The daily dose of gabapentin or placebo was gradually increased to 2,400 mg/day. The intensity of stump and phantom pain was recorded every day on a numeric rating scale (0-10) during the 30-day treatment period. Five interviews were performed after 7, 14, and 30 days and after 3 and 6 months. Results Results from 41 patients were included in the data analysis. The risk of phantom pain (gabapentin vs. placebo) was 55.0% versus 52.6% (risk difference, 2.4%; 95% confidence interval, -28.9 to 33.7%; P = 0.88; 30 days) and 58.8% versus 50.0% (risk difference, 8.8%; 95% confidence interval, -23.3 to 40.9%; P = 0.59; 6 months). The median intensity of phantom pain (gabapentin vs. placebo) was 1.5 (range, 0-9.0) versus 1.2 (range, 0-6.6) (P = 0.60; 30 days) and 1.0 (range, 0-6.0) versus 0.5 (range, 0-5.0) (P = 0.77; 6 months). The median intensity of stump pain was 0.85 (range, 0-8.2) versus 1.0 (range, 0-5.4) (P = 0.68; 30 days) and 0 (range, 0-8.0) versus 0 (range, 0-5.0) (P = 0.58; 6 months). Conclusion Gabapentin administered in the first 30 postoperative days after amputation does not reduce the incidence or intensity of postamputation pain.
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Ferreira, João Pedro, Cécile Couchoud, John Gregson, Aurélien Tiple, François Glowacki, Gerard London, Rajiv Agarwal, and Patrick Rossignol. "Angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, β-blockers or both in incident end-stage renal disease patients without cardiovascular disease: a propensity-matched longitudinal cohort study." Nephrology Dialysis Transplantation 34, no. 7 (December 24, 2018): 1216–22. http://dx.doi.org/10.1093/ndt/gfy378.
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Abstract Background End-stage renal disease (ESRD) patients even without known cardiovascular (CV) disease have high mortality rates. Whether neurohormonal blockade treatments improve outcomes in this population remains unknown. The aim of this study was to assess the effect of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEi/ARBs), β-blockers or both in all-cause mortality rates in incident ESRD patients without known CV disease starting renal replacement therapy (RRT) between 2009 and 2015 in the nationwide Réseau Epidémiologie et Information en Néphrologie registry. Methods Patients with known CV disease and those who started emergency RRT, stopped RRT or died within 6 months were excluded. Propensity score matching models were used. The main outcome was all-cause mortality. Results A total of 13 741 patients were included in this analysis. The median follow-up time was 24 months. When compared with matched controls without antihypertensive treatment, treatment with ACEi/ARBs, β-blockers and ACEi/ARBs + β-blockers was associated with an event-rate reduction per 100 person-years: ACEi/ARBs 7.6 [95% confidence interval (CI) 7.1–8.2] versus matched controls 9.5 (8.8–10.1) [HR 0.76 (95% CI 0.69–0.84)], β-blocker 7.1 (6.6–7.7) versus matched controls 9.5 (8.5–10.2) [HR 0.72 (0.65–0.80)] and ACEi/ARBs + β-blockers 5.8 (5.4–6.4) versus matched controls 7.8 (7.2–8.4) [HR 0.68 (0.61–0.77)]. Conclusions Neurohormonal blocking therapies were associated with death rate reduction in incident ESRD without CV disease. Whether these relationships are causal will require randomized controlled trials.
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Gray, Rosaire P., Timothy J. Hendra, David L. H. Patterson, and John S. Yudkin. "“Spontaneous” Platelet Aggregation in Whole Blood in Diabetic and Non Diabetic Survivors of Acute Myocardial Infarction." Thrombosis and Haemostasis 70, no. 06 (1993): 0932–36. http://dx.doi.org/10.1055/s-0038-1649702.
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SummaryThere is increasing evidence that platelet thrombi play an important role in the pathogenesis of acute myocardial infarction (AMI). We compared “spontaneous” platelet aggregation in whole blood in 17 non-diabetic and 12 diabetic subjects on admission with AML There was no significant difference in the fall in platelet count between the two groups, expressed as platelets remaining (75.2 ± 7.9% vs 77.3 ± 6.9% at 10 min, 66.6 ± 8.9% vs 68.5 ± 6.3% at 20 min, 63.5 ± 8.2% vs 64.9 ± 6.7% at 30 min and 59.4 ± 10.3% vs 61.3 ± 7.6% at 60 min). The rate of “spontaneous” aggregation was increased in subjects with evidence of heart failure on admission compared to those without (59.9 ± 7.9% vs 66.2 ± 6.6% at 30 min [p = 0.05] and 55.4 ± 9.6% vs 63.1 ± 7.7% at 60 min [p = 0.04]). There was no correlation between the fall in platelet count and admission plasma glucose, glycated heaemoglobin or peak aspartate aminotransferase. The subjects studied on admission with AMI had greater rates of “spontaneous” aggregation than 8 subjects studied between 6 and 12 months after acute myocardial infarction (75.9 ± 7.4% vs 85.8 ± 5.4% at 10 min; p = 0.001 and 64.3 ± 7.5% vs 75.0 ± 7.8% at 30 min; p = 0.006) and compared to normal controls (90.7 ± 4.4% at 10 min; p <0.001 and 83.4 ± 6.5 at 30 min; p <0.001). This study provides evidence of increased “spontaneous” platelet aggregation in subjects admitted with acute myocardial infarction but no difference between diabetic and non-diabetic subjects was observed.
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Nakatani, Y., T. Komatsu, U. Shimizu-kaya, T. Itioka, T. Itino, R. Hashim, S. Ueda, W. Asfiya, H. Herwina, and S. Hartini. "Additional species and records of the “horn-backed” Pilophorus plant bugs in Southeast Asia (Heteroptera: Miridae: Phylinae)." Tijdschrift voor Entomologie 159, no. 1 (April 21, 2016): 1–8. http://dx.doi.org/10.1163/22119434-15812050.
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Three new species of the “horn-backed” phyline plant bug genus Pilophorus Hahn, namely, P. erinaceulus, P. maruyamai and P. parvolus, are described from Borneo, Malaysia and Sumatra, Indonesia. The following species are newly recorded within Southeast Asia: P. lambirensis from the Malay Peninsula; P. laticollaris from Sumatra; P. longirostris and P. multivillus from Borneo. A supplementary key to the key by Nakatani et al. (2013) is provided. Y. Nakatani*, Natural Resources Inventory Center, National Institute for Agro-Environmental Sciences, Kannondai, 3-1-3, Tsukuba, Ibaraki, 305-8604, Japan. nakatany@affrc.go.jp T. Komatsu, Institute of Tropical Agriculture, Kyushu University, Hakozaki 6-10-1, Higashi-ku, Fukuoka 812-8581, Japan. corocoro1232000@yahoo.co.jp U. Shimizu-kaya, Center for Ecological Research, Kyoto University, Hirano, Otsu, Shiga 520-2113, Japan. shimizu.kaya.55c@st.kyoto-u.ac.jp T. Itioka, Graduate School of Human and Environmental Studies, Kyoto University, Yoshida-nihonmatsu-cho, Sakyo-ku, Kyoto 606-8501, Japan. ichioka.takao.5m@kyoto-u.ac.jp T. Itino, S. Ueda, Department of Biology, Faculty of Science, Shinshu University 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan. ueda32@shinshu-u.ac.jp R. Hashim, Institute of Biological Science, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. rh4758@gmail.com W. Asfiya, S. Hartini, Division of Zoology, Research Center for Biology, Indonesian Institute of Sciences, Jl. Raya Jakarta-Bogor Km. 46, Cibinong, Bogor, 16911, Indonesia. wara.asfiya@lipi.go.id H. Herwina, Laboratorium Riset Taksonomi Hewan, Jurusan Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Andalas, Kampus UNAND Limau Manis, Padang, 25163, Indonesia. hennyf91@gmail.com
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Penn, Hannah J., Richard M. Johnson, Katie A. Richard, Randy T. Richard, and William H. White. "Lignocellulosic Composition Not Associated with Stem Borer Resistance in Select Louisiana Sugarcane Cultivars." Agronomy 13, no. 11 (November 3, 2023): 2764. http://dx.doi.org/10.3390/agronomy13112764.
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The two most economically damaging insect pests of sugarcane in Louisiana are the sugarcane borer (SCB) and the newly invasive Mexican rice borer (MRB), both of which can be managed in part with cultivar resistance. High stalk fiber levels is a well-documented aspect of stem borer resistance but is inversely correlated with recoverable sugar levels. However, lignocellulosic components such as hemicellulose, cellulose, and lignin are associated with resistance to other borer species in poaceous crops, potentially indicating mechanisms that may provide resistance without substantial trade-offs in yield. The goal of this study was to determine whether lignocellulosic composition varied among four cultivars—HoCP 85-845, HoCP 04-838, Ho 07-613, and HoCP 00-950—selected based on known variation in SCB and MRB resistance and total fiber content. We estimated lignocellulosic composition as well as Brix throughout the growing season and the total stalk fiber and recoverable sugar content at harvest for both plant cane and first ratoon crop years. We found that the Brix content throughout the growing season, as well as total fiber and sugar content at harvest, were significantly associated with the cultivar, aligning with previously documented trends in borer resistance (i.e., higher Brix and lower total fiber indicate a more susceptible cultivar). While lignocellulosic composition during the growing season was not associated with cultivar or resistance to either borer species, it was significantly impacted by sampling month and crop year. These data indicate the potential influence of alternative resistance mechanisms and interactions with abiotic conditions.
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Tyuremnov, I. S., A. S. Krayushkin, and D. A. Shorokhov. "Experimental studies on compaction of soil with HAMM 3411 vibrating roller." Russian Automobile and Highway Industry Journal 19, no. 6 (January 6, 2023): 828–40. http://dx.doi.org/10.26518/2071-7296-2022-19-6-828-840.
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Introduction. Mathematical modelling is used to assess the influence of various factors on the result of soil compaction by a vibratory roller. The verification of the mathematical model is carried out by comparing it with the results of the experimental studies. Expanding the list of the roller models in the experimental studies allows expanding the range of conditions for verification of the mathematical model. The article presents the results of field experimental studies of soil compaction by HAMM 3411 vibrating roller. The data on the change in the value of the dynamic soil deformation modulus Evd depending on the number of passes of the roller during compaction of sandgravel mixture with a layer thickness of 0.5 m have been obtained. The peculiarities that are reasonable to take into account when carrying out further experimental research are revealed.Materials and methods. The experimental studies of the scope of vertical movements of the roller, as well as vertical accelerations of the roller and its frame were carried out on a HAMM 3411 vibrating roller during compaction of a sand-gravel mixture. The result of compaction of the soil after each pass was estimated by the value of the dynamic deformation modulus Evd, measured using the ZORN ZFG 3.0 dynamic loading unit. In the experiment, vertical movements of the vibrating roller were recorded using a BAUMER OADM 13U6480/S35A laser sensor. Accelerations of vibrations of the vibrating roller and the roller frame were recorded by piezoelectric accelerometers of the AR2099-100 and AR99-100 models. When processing sensor readings, digital signal processing technology was used – low-pass filters with a limit frequency of 200 Hz.Results. The studies were carried out on two sites with different soil moisture. On a site with waterlogged soil in the range of Evd values = 10 ...13 MPa, the amplitude values of the vertical accelerations of the roller were in the range from +20 ... +45 to -25 ...-43 m/s2, and the frames in the range from +2.5 ...+5 to -2 ...-5 m/s2. The range of vibrations of the vibrating roller in the area with waterlogged soil was 3.3...4.8 mm. On a site with soil with close to optimal importance, in the range of values Evd= 18...28 MPa, the amplitude values of vertical accelerations of the roller were in the range from +36 ... +48 to -35 ... -40 m/s2, and frames in the range from +3.5 ... +6 to -2...-4.5 m/s2.Discussion and conclusion. The results show that the range of oscillations of the drum, as well as the amplitude values of vertical accelerations of the drum and the drum frame slightly increase with increasing soil deformation modulus Evd. The results of the experiment correlate with the studies conducted on the models of rollers DM-DM-617. When measuring values of Evd in one cross-section, the difference between measured values along the axis of roller’s movement and on the pneumatic wheel track reached 30%. When analyzing obtained results, it is necessary to take into account that in the experiment the actual frequency of oscillation of the roller was 18 Hz, instead of 27 Hz as stated in the technical specifications. With such reduction of frequency, the forced force of oscillations will decrease approximately 2.25 times. Results of the experiment will help in further verification of mathematical model of the roller and in carrying out experimental researches of similar character.
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Mckinley, S. J., and J. R. Hazel. "EPINEPHRINE STIMULATION OF GLUCOSE RELEASE FROM PERFUSED TROUT LIVER: EFFECTS OF ASSAY AND ACCLIMATION TEMPERATURE." Journal of Experimental Biology 177, no. 1 (April 1, 1993): 51–62. http://dx.doi.org/10.1242/jeb.177.1.51.
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Since fish are poikilothermic, changes in temperature may perturb hormonal activation of cell function. To test this hypothesis, and determine the extent to which hormonal responses are thermally compensated, the effect of temperature on epinephrine-stimulated glucose release in perfused trout liver was studied. Thermally acclimated (5 and 20°C) rainbow trout (Oncorhynchus mykiss) were responsive to epinephrine (0.5×10-6 mol l-1) at both 5 and 20°C. Metoprolol (beta2 antagonist) and propranolol (beta1and2) decreased the response significantly (to 1.4 % and 8.4 % of stimulated values, respectively) while phentolamine (alpha1and2) was without effect, implying the response is beta2-mediated. Both basal (86 and 19 micromole g-1 liver h-1 in 5 and 20°C trout, respectively) and epinephrine-stimulated (210 and 168 micromole g-1 h-1) rates of glucose release were higher (2.4-fold higher for epinephrine-stimulated and 8.8-fold for basal) in 5°C- than in 20°C-acclimated fish, regardless of perfusion temperature. Although the dose-response curve for epinephrine was markedly temperature-dependent, cold- and warm-acclimated fish were affected in different ways. Cold-acclimated fish (5°C) were less responsive to epinephrine when perfused at 5°C (ED50 6.8×10-9 mol l-1) than when perfused at 20°C (ED50 8.2×10-10 mol l-1); in contrast, warm-acclimated fish (20°C) were less responsive to epinephrine when perfused at 20°C (ED50 4.6×10-7 mol l-1) than at 5°C (ED50 6.6×10-9 mol l-1). These results are interpreted as being indicative of adaptations to maintain the capacity for hepatic glucose mobilization at low temperature.
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Meyer, L., F. C. Wehner, L. H. Nel, and D. E. Carling. "Characterization of the Crater Disease Strain of Rhizoctonia solani." Phytopathology® 88, no. 4 (April 1998): 366–71. http://dx.doi.org/10.1094/phyto.1998.88.4.366.
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Crater disease (CD) of wheat is caused by a Rhizoctonia solani strain of ambiguous phylogeny. Anastomosis reactions confirmed placement of CD-causing R. solani in anastomosis group (AG) 6, with results indicating a closer affinity to AG-6 GV than to AG-6 HG. Cultures of CD isolates were initially white to cream, turning a yellowish light brown after 10 days. Concentric rings of dark and light mycelium were evident from an early stage. Mycelium generally was appressed to the agar surface, with sparse aerial growth. A few light-colored, irregularly shaped sclerotia could be discerned after 2 weeks. The mean hyphal diameter of CD-causing R. solani was 7.46 μm (ranging from 5.0 to 10.0 μm), and cells contained a mean number of four (ranging from two to eight) nuclei, compared to a mean hyphal diameter of 8.58 and 8.42 μm and a mean nuclear number of six and four for AG-6 HG and AG-6 GV, respectively. The CD isolates had a slower growth rate (15.3 mm/day) than AG-6 HG (29.1 mm/day) and AG-6 GV (22.6 mm/day) but, like AG-6, were thiamine prototrophic. Conspicuous nodulose swellings were produced by CD-causing R. solani on roots of wheat, and infection resulted in retarded shoot growth. Smaller nodules were evident on bean and soybean roots. Fingerprint patterns generated for the various isolates with four enzymes, HpaII, Sau3AI, TaqI, and CfoI, showed the presence of a unique 610-bp fragment in the pathogen. It is proposed that CD-causing R. solani isolates represent a distinct intersterility group within AG-6 that is more related to subgroup GV than to subgroup HG.
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Ulrych, Jaromír, Lukáš Ackerman, Václav Kachlík, Ernst Hegner, Kadosa Balogh, Anna Langrová, Jan Luna, Ferry Fediuk, Miloš Lang, and Jiří Filip. "Constraints on the origin of gabbroic rocks from the Moldanubian-Moravian units boundary (Bohemian Massif, Czech Republic and Austria)." Geologica Carpathica 61, no. 3 (June 1, 2010): 175–91. http://dx.doi.org/10.2478/v10096-010-0009-0.
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Constraints on the origin of gabbroic rocks from the Moldanubian-Moravian units boundary (Bohemian Massif, Czech Republic and Austria)Gabbroic bodies from the Moldanubian Monotonous Group (Maříž) and the Moravian Vratěnín Unit (other sites), often showing retrogressive recrystallization at their margins in the amphibolite-facies grade, have norite, gabbronorite, gabbro and hornblendite compositions. Gabbros with preserved coronitic textures are limited to the Vratěnín Unit. The estimated equilibration temperatures derived from plagioclase-amphibole pairs and orthopyroxene Ca contents calculated for pressures 5-10 kbar overlap for coronitic (700-840 °C) and non-coronitic gabbroic rocks (680-850 °C). Although the Moldanubian (Maříž) gabbroic rocks are more Mg-rich compared to the Moravian gabbroids, they show crust-like La/Nb ratios of 2.1-6.6 characteristic of subduction-related magmatic rocks coupled with uniform low εNdvalues of + 0.6 to + 0.7. Apparent subduction-related features are probably caused by contamination by juvenile crust and/or by metamorphic fluid rich in incompatible elements during the Variscan metamorphism. Samples from Korolupy-Nonndorf and Mešovice have La/Nb ratios < 1.7 and show negative correlations between La/Nb and εNd. Such decoupling between La/Nb and εNdcould be attributed to contamination of the subduction-related parent magma by crustal material with higher La/Nb and lower εNdvalues. Samples from Uherčice show ambiguous geochemical patterns inherited from contamination by very old recycled material. Gabbroic rocks from Maříž should represent an underplated, partly layered cumulate body of continental tholeiite composition, strongly influenced by crustal contamination. In contrast, gabbroic bodies from the Vratěnín Unit, having a close spatial relationship to the surrounding garnet amphibolites, were emplaced into a lithologically variable passive margin sequence probably during the Cadomian extension.
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McKay, Rana R., Shayan Nazari, Andrew Elliott, Brent S. Rose, Pedro C. Barata, Deepak Kilari, Rohan Garje, et al. "Molecular and clinical correlates of high PSMA/FOLH1 mRNA expression in primary and metastatic prostate cancer (PC)." Journal of Clinical Oncology 42, no. 16_suppl (June 1, 2024): 5051. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.5051.
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5051 Background: The FOLH1 gene encodes prostate-specific membrane antigen (PSMA), a transmembrane glycoprotein that is expressed in PC cells. PSMA is a target for diagnostic imaging and treatment in PC. We utilized a database of molecularly profiled PC tumors to evaluate correlates of high FOLH1 mRNA expression. Methods: NextGen sequencing of DNA (592-gene/whole exome) and RNA (whole transcriptome) was performed on PC specimens (n=7,558) through Caris Life Sciences. FOLH1-High/Low expression was defined as above/below median RNA transcripts per million (TPM). Androgen receptor (AR), neuroendocrine (NEPC), MAPK, and T-cell inflamed RNA signature scores were calculated. Tumor cell PD-L1+ expression (≥2+, ≥5%; SP142) was assessed by IHC. Overall survival (OS) and time on treatment (TOT) were calculated from time of diagnosis or therapy start. Results: Specimens were derived from the prostate gland (n=4495, 59.5%), lymph nodes (n=858, 11.4%), bone (n=568, 7.5%), liver (n=359, 4.7%), urinary tract (n=340, 4.5%), lung (n=116, 1.5%), and other metastatic sites (n=822, 10.9%). Relative to the prostate (390.9 TPM), FOLH1 mRNA expression varied by metastatic site, with highest expression in lymph nodes (518.2 TPM, p<0.001) and lowest expression in lung (209.7 TPM, p<0.001) and liver metastases (143.1 TPM, p<0.001). Higher FOLH1 expression significantly correlated with presence of AR-V7 variants (18% vs 15%) and ASXL1 (6% vs 3.9%) alterations, and fewer alterations in FOX1A (7.9% vs 10.6%), APC (4% vs 10.3%), PIK3CA(3.1% vs 6.4%), CTNNB1 (3.1% vs 4.8%), and PIK3R1 (0.7% vs 2%). High FOLH1 expression positively associated with AR signaling score, MAPK activation, and T-cell inflammation, and negatively correlated with NEPC signaling (all p<0.001). Tumors with high FOLH1 expression were more frequently PD-L1+ (3.9% vs 2.2%, p<0.01). Among primary tumors, OS was similar between FOLH1 high and low groups; however, among metastatic tumors, OS was improved in patients (pts) with high FOLH1 expression compared to low expression (96.3 vs 87.9 months, HR 0.82 95% CI 0.73-0.92). There was no difference in TOT among pts receiving ARSIs, taxanes, or PARPi. Among 149 pts that received 177Lu-PSMA-617, there was a trend towards improved TOT in FOLH1-high (n=78) versus -low (n=71) tumors (HR 0.76, 95%CI 0.55-1.05). Conclusions: This is the largest combined genomic, transcriptomic and survival outcomes analysis of PSMA ( FOLH1) expression in PC. In PC, greater FOLH1 mRNA expression was associated with higher AR signaling scores and AR-V7 expression, and fewer mutations in the Wnt and PI3K pathways. FOLH1-high pts showed greater T cell inflammation and PD-L1 expression, and lower NEPC signaling. High FOLH1 expression was associated with greater OS among patients with metastatic tumors, with a trend towards improved outcomes to 177Lu-PSMA-617. Such pts may benefit from distinct therapeutic strategies.
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Andriani, Alessandro, Roberto Latagliata, Michele Cedrone, Ambra Di Veroli, Cristina Santoro, Francesca Spirito, Carla Ruscio, et al. "Are ET and PV Patients Two Similar Populations As Concern Thrombotic Risk Factors?" Blood 126, no. 23 (December 3, 2015): 2811. http://dx.doi.org/10.1182/blood.v126.23.2811.2811.
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Abstract Thrombotic events are major complications in patients (pts) affected by Essential Thrombocytemia (ET) and Polycytemia Vera (PV). To compare thrombotic risk in these 2 groups, we evaluated retrospectively our database of 1249 ET and 623 PV pts diagnosed and followed in 11 hematological centers in the Latium region between 1/1980 and 12/2010: the diagnosis was done according to PVSG, WHO 2001 and 2008criteria based on the time of first observation. Baseline features of ET pts: 797F/452M,median age 62.9 yrs (range 19-96),median WBC count 8.8 x 109/L (range 1.2-57.7), median PLT count 812 x 109/L (range 457-3582), median Hb level 14.0 g/dl (range 6-20.5), JAK-2V617F positivity 59.7% with a median allele burden of 19,6% (range 0.2- 99.9), spleen enlargement in 18.7% of pts, previous thrombosis223/1239 evaluable pts (17.9%) [arterial 176/223 (14.1%), venous 47/223 (3.8%)]. Baseline features of PV pts: 289F/334M, median age 63.0yrs (range 21-91), median WBC count 10.1 x 109/L (range 3.5-37.6), median PLT count 457 x 109/L (range 169-1790), median Hb level 18.2 g/dl (range 10.5-24.8), JAK-2V617F positivity 94.3% with a median allele burden of 59.1% (range 0.3-99.9), spleen enlargement in 42% of patients, previous thrombosis 146/617 evaluable pts (23.7%)[arterial 114/617 (18.5%), venous 32/617 (5,2%)].in the ET cohort, after a median follow-up of 7.7 yrs, thrombotic complications were seen in 107/1141 evaluable pts (9.4%) [arterial60 (5.25%), venous 47 (4.11%)]; in the PV cohort, after a median follow-up of 8.5 yrs, thrombotic complications were seen in 107/623pts (17.2%) [arterial 67 (10.8%),venous 40 (6.4%)].All common risk factors for thrombosis were evaluated in multivariate analysis, searching the cut-off number for continuous variables with ROC curves. The significant variables at multivariate analysis for ET and PV pts are shown in the table; age, previous thromboses and spleen enlargement were risk factors in ET pts, while previous thromboses and JAK-2V617F allele burden were risk factors in PV pts. PLT count above ROC value seemed to be a protective factor in both cohorts. In conclusion, in contrast with the tendency to evaluate in a similar manner the thrombotic risk of PV and ET, data from our retrospective database showed that these 2 groups should be considered populations with different risk factors for thrombosis. Table 1.Putative prognostic factorsPolycythemia VeraEssential ThrombocythemiaHR95% C.I.pHR95% C.I .pPrevious thromboses2,311,13 - 4,740,021,871,08 -3,230,026Age ≥ 60 y1,540,79 - 2,990,211,901,18 - 3,060,009JAK2V617FPV: allelic burden ≥ 81% ET: pos1,951,03 - 3,710,040,760,48 - 1,210,25Plt countPV ≥ 452.109/L ET ≥ 944.109/L0,490,25 - 0,950,040,520,31 - 0,890,017Spleen enlargement0,670,34 -1,310,241,711,02 - 2,890,04CV risk factors (at least 1)0,920,41 - 2,030,830,870,51 - 1,490,62WBCPV ≥ 10,175.109/L ET ≥ 9,630.109/L1,090,57 - 2,080,801,410,89 -2,260,15 Disclosures No relevant conflicts of interest to declare.
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Jette, Diane U., Mary Stilphen, Vinoth K. Ranganathan, Sandra Passek, Frederick S. Frost, and Alan M. Jette. "Interrater Reliability of AM-PAC “6-Clicks” Basic Mobility and Daily Activity Short Forms." Physical Therapy 95, no. 5 (May 1, 2015): 758–66. http://dx.doi.org/10.2522/ptj.20140174.
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BackgroundThe interrater reliability of 2 new inpatient functional short-form measures, Activity Measure for Post-Acute Care (AM-PAC) “6-Clicks” basic mobility and daily activity scores, has yet to be established.ObjectiveThe purpose of this study was to examine the interrater reliability of AM-PAC “6-Clicks” measures.DesignA prospective observational study was conducted.MethodsFour pairs of physical therapists rated basic mobility and 4 pairs of occupational therapists rated daily activity of patients in 1 of 4 hospital services. One therapist in a pair was the primary therapist directing the assessment while the other therapist observed. Each therapist was unaware of the other's AM-PAC “6-Clicks” scores. Reliability was assessed with intraclass correlation coefficients (ICCs), Bland-Altman plots, and weighted kappa.ResultsThe ICCs for the overall reliability of basic mobility and daily activity were .849 (95% confidence interval [CI]=.784, .895) and .783 (95% CI=.696, .847), respectively. The ICCs for the reliability of each pair of raters ranged from .581 (95% CI=.260, .789) to .960 (95% CI=.897, .983) for basic mobility and .316 (95% CI=−.061, .611) to .907 (95% CI=.801, .958) for daily activity. The weighted kappa values for item agreement ranged from .492 (95% CI=.382, .601) to .712 (95% CI=.607, .816) for basic mobility and .251 (95% CI=.057, .445) to .751 (95% CI=.653, .848) for daily activity. Mean differences between raters' scores were near zero.LimitationsRaters were from one health system. Each pair of raters assessed different patients in different services.ConclusionsThe ICCs for AM-PAC “6-Clicks” total scores were very high. Levels of agreement varied across pairs of raters, from large to nearly perfect for physical therapists and from moderate to nearly perfect for occupational therapists. Levels of agreement for individual item scores ranged from small to very large.
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Carvalho, Marcos, Pedro Sá Cardoso, Cristina Alves, Inês Balacó, Tah Pu Ling, and Gabriel Matos. "Deformidade de Madelung – Resultado estético e funcional do tratamento cirúrgico com osteotomia em cúpula do rádio distal e secção do ligamento de Vickers." Revista Brasileira de Ortopedia 57, no. 01 (October 1, 2021): 113–19. http://dx.doi.org/10.1055/s-0041-1731362.
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Resumo Objetivo Avaliar o resultado estético e funcional do tratamento cirúrgico da deformidade de Madelung em idade pediátrica. Método Estudo retrospectivo dos pacientes com deformidade de Madelung em idade pediátrica tratados cirurgicamente através de osteotomia em cúpula do rádio distal e secção do ligamento de Vickers entre 2015 e 2018. Foram incluídos doentes com tempo de seguimento pós-operatório mínimo de 12 meses. Foram analisados dados demográficos, técnica cirúrgica, resultados clínicos e radiográficos. A avaliação radiográfica pré e pós-operatória consistiu na medição da inclinação ulnar, do afundamento semilunar, do ângulo da fossa semilunar e do desvio palmar do carpo. A avaliação clínica pós-operatória consistiu na medição das amplitudes articulares do punho, escala visual analógica (EVA) e score Disabilities of the Arm, Shoulder and Hand (DASH). Resultados Foram incluídos quatro pacientes, dois com Madelung idiopática e dois com displasia óssea, todos do sexo feminino e com doença bilateral. Foram operados 6 punhos, a idade mediana à data de cirurgia foi 15,5 anos, e o tempo mediano de seguimento pós-operatório foi de 37,5 meses. Na análise radiográfica pós-operatória, verificou-se uma correção média de 8,8 ± 7,5° da inclinação ulnar, de 3 ± 3,9 mm do afundamento semilunar, de 8,2 ± 6,6° do ângulo da fossa semilunar e de 4,7 ± 2,6 mm do desvio palmar do carpo. Na avaliação da amplitude articular média pós-operatória, registrou-se uma flexão de 75,8 ± 3,4°; extensão de 62,5 ± 14,1°; desvio radial de 25,7 ± 2,9°; desvio cubital de 40,0 ± 2,9; pronação de 88,3 ± 2,4°; supinação de 82,5 ± 2,5°. Registou-se EVA mediana para dor residual = 1, défice funcional = 0, prejuízo estético = 0, e recomendação de procedimento cirúrgico = 10. A mediana do score DASH foi 0. Conclusão O tratamento da deformidade de Madelung através da osteotomia em cúpula do rádio distal e secção do ligamento de Vickers permite obter um excelente resultado estético e funcional.
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Tveita, Torkjel, Grace M. Arteaga, Young-Soo Han, and Gary C. Sieck. "Cardiac troponin-I phosphorylation underlies myocardial contractile dysfunction induced by hypothermia rewarming." American Journal of Physiology-Heart and Circulatory Physiology 317, no. 4 (October 1, 2019): H726—H731. http://dx.doi.org/10.1152/ajpheart.00101.2019.
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Rewarming the intact heart after a period of hypothermia is associated with reduced myocardial contractility, decreased Ca2+ sensitivity, and increased cardiac troponin-I (cTnI) phosphorylation. We hypothesized that hypothermia/rewarming (H/R) induces left ventricular (LV) contractile dysfunction due to phosphorylation of cTnI at Ser23/24. To test this hypothesis, the response of wild-type mice ( n = 7) to H/R was compared with transgenic (TG) mice expressing slow skeletal TnI (TG-ssTnI; n = 7) that lacks the Ser23/24 phosphorylation sites. Hypothermia was induced by surface cooling and maintained at 23–25°C for 3 h. Subsequently, the animals were rewarmed to 37°C. LV systolic and diastolic function was assessed using a 1.4 F pressure-volume Millar catheter introduced via the right carotid artery. At baseline conditions, there were no significant differences in LV systolic function between wild-type and TG-ssTnI mice, whereas measurements of diastolic function [isovolumic relaxation constant (τ) and end-diastolic pressure-volume relationship (EDPVR)] were significantly ( P < 0.05) reduced in TG-ssTnI animals. Immediately after rewarming, significant differences between groups were found in cardiac output (CO; wild-type 6.6 ± 0.7 vs. TG-ssTnI 8.8 ± 0.7 mL/min), stroke work (SW; wild-type 796 ± 112 vs. TG-ssTnI 1208 ± 67 mmHg/μL), and the preload recruited stroke work (PRSW; wild-type 38.3 ± 4.9 vs. TG-ssTnI 68.8 ± 8.2 mmHg). However, EDPVR and τ returned to control levels within 1 h in both groups. We conclude that H/R-induced LV systolic dysfunction results from phosphorylation of cTnI at Ser23/24. NEW & NOTEWORTHY Rewarming following a period of accidental hypothermia leads to a form of acute cardiac failure (rewarming shock), which is in part due to reduced sensitivity to Ca2+ activation of myocardial contraction. The results of the present study support the hypothesis that rewarming shock is due to phosphorylation of cardiac troponin I.
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Demir, Ibrahim, Canan Oztokat Kuzucu, Sıtkı Ermis, and Güleda Öktem. "Radicle Emergence as Seed Vigour Test Estimates Seedling Quality of Hybrid Cucumber (Cucumis sativus L.) Cultivars in Low Temperature and Salt Stress Conditions." Horticulturae 9, no. 1 (December 20, 2022): 3. http://dx.doi.org/10.3390/horticulturae9010003.
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This work was conducted on the use of the RE (radicle emergence) test to estimate the seedling emergence (SE) and quality (seedling shoot weight (SSW), seedling root weight (SRW) and seedling height (SH)) of twelve hybrid cucumber seed lots with high germination (>95%) at low temperature conditions, high salt conditions and a combination of the two. The percentages of RE, which is a 2 mm radicle protrusion at 25 °C in the dark, were counted between 18 h and 32 h. The seeds were sown in peat moss in trays and kept at 15 °C (low temperature stress), or salty water was applied as 100 mM NaCl at 25 °C (salt stress) for three days, and both were applied in a combined-stress environment. Seedling emergence and quality parameters were reduced by both stress environments and their combination. SE, SSW, SRW and SH values ranged between: 91–100%, 614–844 mg, 102–143 mg, 6.8–8.8 cm at low temperature; 90–98%, 598–904 mg, 101–154 mg, 6.5–7.8 cm at salt stress; and 76–92%, 464–608 mg, 97–133 mg, 5.8–6.9 cm at their combination. The RE values with great differences seen among the lots (20–28 h) were regressed with seedling emergence and quality values. RE 24 h had the highest R2 and significant values in all stress environments as R2 = 0.596-0.858, p < 0.05–0.001 at low temperature; R2 = 0.620–0.827, p < 0.05–0.001 with salt; and R2 = 0.686-0.842, p < 0.05–0.001 with combined stresses. We concluded that RE as a vigour test can be used successfully to estimate the seedling quality of highly germinating hybrid cucumber seed lots. Use of the RE test in hybrid cucumber seeds and its influence on high-quality seedling production were discussed.