Academic literature on the topic '572.829 0285'

Abstract BACKGROUND Resection may be appropriate for select patients with recurrent glioblastoma. The incidence of histopathological findings related to prior treatment and their prognostic implications are incompletely characterized. OBJECTIVE To quantify the incidence and survival outcomes associated with treatment effect at resection of recurrent glioblastoma (GBM). METHODS Patients who underwent resection for recurrent GBM were retrospectively reviewed, and pathology, treatment history, and survival data were collected. Treatment effect was defined as any component of treatment-related changes on pathology. RESULTS In total, 110 patients underwent 146 reoperations. Median age at first reoperation was 57.2 yr and overall survival from reoperation was 10.8 mo. Treatment effect of any kind was noted in 81 of 146 reoperations (55%). Increased treatment effect was observed closer to radiotherapy; by quartile of time from radiotherapy, the rates of treatment effect were 77.8%, 55.6%, 40.7%, and 44.4% (P = .028). Treatment effect was associated with earlier reoperation (8.9 vs 13.8 mo after radiotherapy, P = .003), and the presence of treatment effect did not impact survival from primary surgery (25.4 vs 24.3 mo, P = .084). Patients treated with bevacizumab prior to reoperation were less likely to have treatment effect (20% vs 65%, P < .001). CONCLUSION Histopathological treatment-related changes are evident in a majority of patients undergoing resection for recurrent glioblastoma. There was no association of treatment effect with overall survival from primary surgery.

93 Background: A key eligibility criterion in many active surveillance (AS) programs is that the biopsy exhibit only Gleason pattern 3 (G3) for a Gleason score of 6 or less. However, 25 to 35% of biopsy Gleason 6 is upgraded to Gleason 7 or higher in the prostatectomy (RP) specimen. Thus, there is a great need for biomarkers that, when measured on G3 tissue in a Gleason 6 biopsy, can predict the presence of unsampled higher grade tumor in the whole prostate. We evaluated PTEN loss by immunohistochemistry (IHC), and PTEN deletion, chromosome 8q (MYC) gain and 8p (LPL) loss by fluorescence in situ hybridization (FISH) for their ability to predict unsampled G4 tumor. Methods: A tissue microarray (TMA) was constructed of RP tissue from three groups of patients (n=50 per group) whose prostates exhibited only Gleason 3+3, only 3+4, or only 4+3 tumor, matched on age, year of RP, and race. In each patient, multiple cores sampled only from areas of G3 were evaluated for PTEN deletion by FISH, PTEN loss by IHC, and chromosome 8p/8q alterations by FISH. Biomarker results were compared between Gleason 6 versus 7 tumors using conditional logistic regression. Results: Patients underwent RP in 2001 to 2009, had median age 60, and median prostate-specific antigen 5.2; 63% of tumors were organ confined. In univariate analyses 8q gain (odds ratio OR=8.9, p<.0001), 8p loss (OR=6.9, p<.0001), PTEN loss by IHC (OR=5.7, p=.025), but not PTEN deletion by FISH (OR=1.5, p=.477) were significantly more common in G3 cores from Gleason 7 tumors than G3 cores from Gleason 6 tumors. In multivariable analyses, 8q gain (OR=6.2, p=.002) and 8p loss (OR=5.2, p=.0002) remained highly significant. At least one high risk biomarker (8q gain, 8p loss, PTEN loss, or PTEN deletion) was found in 35.7% of Gleason 3+3 versus 77.1% of Gleason 3+4 versus 91.3% of Gleason 4+3 tumors, p<.0001. Adjustment for confounding factors did not change the results. Conclusions: Chromosomal 8q gains (MYC), 8p loss (LPL), and PTEN loss measured in Gleason G3 TMA cores strongly differentiate whether the core comes from Gleason 6 or Gleason 7 tumor. If validated in biopsy Gleason 6 cores to predict prostatectomy Gleason 7 tumor these biomarkers could facilitate safe selection of men for active surveillance.

ABSTRACT The stability of Islamic finance has made many researchers interested in discussing Islamic finance. Sukuk is included in one of the widely published areas of Islamic finance, making it a topic of discussion in several scholarly forums. This study used the Scopus database, where there were 2,128 articles related to sukuk in the Scopus web in 2011-2021, but only 108 articles were included in the criteria and used as a research sample using bibliometric methods and SLR to obtain results related to publication activities, popular topics, research trends, and recommendations for research directions related to sukuk. In the bibliometric analysis method with the help of biblioshiny applications and SLR analysis by reviewing each article and grouping research topics. The results showed that sukuk related publication articles were spread in several countries that were not restricted. Malaysia is the country with the most publications related to sukuk, and most often conducts research collaborations in both Multiple Country Collaboration (MPC) and Single Country Collaboration (SCP). The results of SLR analysis have four themes that are most discussed in research related to sukuk, so researchers provide recommendations for further research directions that can be used by researchers in the future, such as adding research using qualitative methods or discussing the impact of sukuk performance in real terms not only from secondary data. Keywords: Bibliometric, Islamic Bond, Sukuk, Systematic Literature Review (SLR). ABSTRAK Stabilnya Keuangan Islami menjadikan banyak peneliti yang tertarik membahas Keuangan Islami. Sukuk termasuk dalam salah satu sektor Keuangan Islami yang banyak diterbitkan sehingga menjadikan sukuk sebagai topik bahasan diskusi dalam beberapa forum ilmiah. Penelitian ini menggunakan database scopus dimana terdapat 2.128 artikel terkait sukuk pada tahun 2011-2021 dalam web scopus, akan tetapi hanya 108 artikel yang masuk dalam kriteria dan dijadikan sampel penelitian dengan menggunakan metode bibliometrik dan SLR untuk mendapatkan hasil terkait aktivitas publikasi, tema popular, tren penelitian dan rekomendasi arah penelitian terkait sukuk. Pada metode bibliometrik analisis menggunakan bantuan aplikasi biblioshiny dan analisis SLR dengan melakukan review setiap artikel dan mengelompokkan tema penelitian. Hasil penelitian menunjukkan artikel publikasi terkait sukuk tersebar di beberapa negara yang tidak dibatasi. Malaysia merupakan negara dengan publikasi terbanyak terkait sukuk dan paling sering melakukan kolaborasi penelitian baik secara Multiple Country Collaboration (MPC) dan Single Country Collaboration (SCP). Hasil analisis SLR terdapat empat tema yang paling banyak dibahas dalam penelitian terkait sukuk, sehingga peneliti memberikan rekomendasi arah penelitian selanjutnya yang dapat digunakan oleh peneliti selanjutnya dengan menambah penelitian menggunakan metode kualitatif atau membahas dampak kinerja sukuk secara real bukan hanya dari data sekunder. Kata Kunci: Bibliometric, Islamic Bond, Sukuk, Systematic Literature Review (SLR). REFFERENCES Ahmad, A. U. F., Muneeza, A., Farooq, M. O., & Hasan, R. (2018). Post-default sukuk restructuring: an appraisal of shari’ah issues. In Hassan, M.K. and Rashid, M. (Ed.) Management of Islamic Finance: Principle, Practice, and Performance (pp. 113–128). Bingley: Emerald Publishing Limited Al Fathan, R., & Arundina, T. (2019). Finance-growth nexus: Islamic finance development in Indonesia. International Journal of Islamic and Middle Eastern Finance and Management, 12(5), 698–711. doi:10.1108/IMEFM-09-2018-0285 Al Madani, H., Alotaibi, K. O., & Alhammadi, S. (2020). The role of Sukuk in achieving sustainable development: Evidence from the Islamic Development Bank. Banks and Bank Systems, 15(4), 36–48. doi:10.21511/bbs.15(4).2020.04 Ashraf, D., Rizwan, M. S., & Azmat, S. (2020). Not one but three decisions in sukuk issuance: Understanding the role of ownership and governance. Pacific Basin Finance Journal, 69. doi:10.1016/j.pacfin.2020.101423 Aziz, S., Ashraf, D., & El-Khatib, R. (2021). Societal trust and Sukuk activity. Journal of International Financial Markets, Institutions and Money, 74. doi:10.1016/j.intfin.2021.101384 Bahoo, S. (2020). Corruption in banks: A bibliometric review and agenda. Finance Research Letters, 35. doi:10.1016/j.frl.2020.101499 Baker, H. K., Kumar, S., & Pandey, N. (2019). Thirty years of the Global Finance Journal: A bibliometric analysis. Global Finance Journal, 47. doi:10.1016/j.gfj.2019.100492 Baker, H. K., Kumar, S., & Pattnaik, D. (2020). Twenty-five years of review of financial economics: A bibliometric overview. Review of Financial Economics, 38(1), 3–23. doi:10.1002/rfe.1095 Balli, F., Ghassan, H., & Al Jeefri, E. H. (2021). Sukuk and bond spreads. Journal of Economics and Finance, 45(3), 529–543. doi:10.1007/s12197-021-09545-9 Brahmana, R. K., & You, H. W. (2021). Do muslim CEOs and muslim stakeholders prefer Islamic debt financing? Global Finance Journal, 54. doi:10.1016/j.gfj.2021.100625 Braun, V., & Clarke, V. (2006). Using thematic analysis in psychology. Qualitative Research in Psychology, 3(2), 77–101. doi:10.1191/1478088706qp063oa Comerio, N., & Strozzi, F. (2019). Tourism and its economic impact: A literature review using bibliometric tools. Tourism Economics, 25(1), 109–131. doi:10.1177/1354816618793762 Donohue, J. C. (1972). A bibliometric analysis of certain information science literature. Journal of the American Society for Information Science, 23(5), 313–317. doi:10.1002/asi.4630230506 El-Khatib, R. (2017). Determinants of corporate leverage in publicly listed GCC companies - Conventional versus Sukuk. Advances in Financial Economics, 19, 77–102. doi:10.1108/S1569-373220160000019004 Ernawati, E., & Asri, M. (2020). Knowledge and awareness of Islamic Financial in Europe And America Countries. Iqtishadia: Jurnal Kajian Ekonomi dan Bisnis Islam, 13(1), 23-37. doi:10.21043/iqtishadia.v13i1.7207 Godlewski, C. J., Turk-Ariss, R., & Weill, L. (2016). Do the type of sukuk and choice of shari’a scholar matter? Journal of Economic Behavior and Organization, 132, 63–76. doi:10.1016/j.jebo.2016.04.020 Haddow, G. (2018). Bibliometric research. In Research Methods: Information, Systems, and Contexts: Second Edition (pp. 241–266). Cambrige: Elsevier Ltd. Hasan, R., Ahmad, A. U. F., & Parveen, T. (2019). Sukuk risks – A structured review of theoretical research. Journal of Islamic Accounting and Business Research, 10(1), 35–49. doi:10.1108/JIABR-06-2015-0026 Hidayat, T. (2011). Buku pintar investasi Syariah. Jagakarsa: PT TransMedia. Ishak. (2008). Pengelolaan perpustakaan berbasis teknologi informasi. Jurnal Study Perpustakaan dan Informasi, 4(3). Islamic Corporation for the Development of the Private Sector. (2020). Islamic finance development report 2020: progressing through adversity. Retrieved from https://icd-ps.org/uploads/files/ICD-Refinitiv IFDI Report 20201607502893_2100.pdf Islamic Financial Service Board. (2020). Islamic financial services industry stability report 2020. Retrieved from https://www.ifsb.org/download.php?id=5724&lang=English&pg=/sec03.php Jaidka, K., Khoo, C. S. G., & Na, J. C. (2013). Literature review writing: How information is selected and transformed. Aslib Proceedings: New Information Perspectives, 65(3), 303–325. doi:10.1108/00012531311330665 Jalil, M. J. A., & Rahman, Z. A. (2012). Sukuk investment: Comparison of the profits obtained by using Ijarah and Musharakah Mutanaqisah principles with long-term tenure. Qualitative Research in Financial Markets, 4(2–3), 206–227. doi:10.1108/17554171211252538 Kholis, N. (2017). Potret perkembangan dan praktik keuangan Islam di dunia. Millah: Journal of Religious Studies, 1(1), 1-30. doi:10.20885/millah.vol17.iss1.art1 Laila, N. (2019). Pengembangan sukuk negara di Indonesia:Analisis komprehensif dalam menggali alternatif solusi dan strategi pengembangan sukuk negara Indonesia (B. H. Suhesta (ed.)). Sidoarjo: Nizamia Learning Center 2019 Liu, Z., Yin, Y., Liu, W., & Dunford, M. (2015). Visualizing the intellectual structure and evolution of innovation systems research: a bibliometric analysis. Scientometrics, 103(1), 135–158. doi:10.1007/s11192-014-1517-y Majelis Ulama Indonesia. (2020). Fatwa Dewan Syariah Nasional-Majelis Ulama Indonesia no: 137/DSN-MUIAX2020 Tentang SUKUK. 19, 1–8. Retrieved from https://www.shariaknowledgecentre.id/id/.galleries/pdf/fatwa/capital-market/137-sukuk.pdf Majumdar, S., & Puthiya, R. (2021). Role of signaling in issuance of sukuk versus conventional bonds – an empirical analysis of the bond market in the UAE. International Journal of Islamic and Middle Eastern Finance and Management, 14(5), 967–981. doi:10.1108/IMEFM-02-2020-0093 Melis. (2017). Perkembangan sukuk di indonesia, malaysia, dan dunia. Ekonomica Sharia: Jurnal Pemikiran dan Pengembangan Ekonomi Syariah, 2(2), 75–88. Mohamed, H. H., Masih, M., & Bacha, O. I. (2015). Why do issuers issue Sukuk or conventional bond? Evidence from Malaysian listed firms using partial adjustment models. Pacific Basin Finance Journal, 34, 233–252. doi:10.1016/j.pacfin.2015.02.004 Naifar, N., & Hammoudeh, S. (2016). Do global financial distress and uncertainties impact GCC and global sukuk return dynamics? Pacific Basin Finance Journal, 39, 57–69. doi:10.1016/j.pacfin.2016.05.016 Naim, A. M., Isa, M. Y., & Hamid, M. L. (2013). The effects of new AAOIFI standards on Sukuk in choosing the most authentic Islamic principles. Journal of Islamic Accounting and Business Research, 4(1), 77–93. doi:10.1108/17590811311314302 Oseni, U. A., & Hassan, M. K. (2015). Regulating the governing law clauses in Sukuk transactions. Journal of Banking Regulation, 16(3), 220–249. doi:10.1057/jbr.2014.3 Paltrinieri, A., Hassan, M. K., Bahoo, S., & Khan, A. (2020). A bibliometric review of sukuk literature. International Review of Economics and Finance, 86, 897-918. doi:10.1016/j.iref.2019.04.004 Pirgaip, B., Arslan-Ayaydin, Ö., & Karan, M. B. (2020). Do Sukuk provide diversification benefits to conventional bond investors? Evidence from Turkey. Global Finance Journal, 50, 1–18. doi:10.1016/j.gfj.2020.100533 Pritchard, A. (1969). Statistical Bibliography or Bibliometrics. Journal of Documentation, 25(4), 348–349. Rasul, T. (2019). The trends, opportunities and challenges of halal tourism: A systematic literature review. Tourism Recreation Research, 44(4), 434–450. doi:10.1080/02508281.2019.1599532 Razak, S. S., Saiti, B., & Dinç, Y. (2019). The contracts, structures and pricing mechanisms of sukuk: A critical assessment. Borsa Istanbul Review, 19, S21–S33. doi:10.1016/j.bir.2018.10.001 Rossetto, D. E., Bernardes, R. C., Borini, F. M., & Gattaz, C. C. (2018). Structure and evolution of innovation research in the last 60 years: Review and future trends in the field of business through the citations and co-citations analysis. Scientometrics, 115(3), 1329–1363. doi:10.1007/s11192-018-2709-7 Saeed, M., Elnahass, M., Izzeldin, M., & Tsionas, M. (2021). Yield Spread Determinants of Sukuk and Conventional Bonds. Economic Modelling, 105. doi:10.1016/j.econmod.2021.105664 Sherif, M., & Erkol, C. T. (2017). Sukuk and conventional bonds: Shareholder wealth perspective. Journal of Islamic Accounting and Business Research, 8(4), 347–374. doi:10.1108/JIABR-09-2016-0105 Smaoui, H., & Ghouma, H. (2020). Sukuk market development and Islamic banks’ capital ratios. 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Abstract In recent years, alternative approaches have been implemented in the automotive sector to reduce raw material costs and protect the environment. An increase in weight causes both fuel consumption and CO2 emissions to rise. This study aims to reduce exhaust emissions due to weight reduction by using foamed polypropylene in the door panel production of a subcompact crossover SUV car and saving energy by shortening the injection cycle time. The newly produced 2 % ITP 822 chemical foaming agent added door panel was compared with the current door panel performances. As a result of foam morphology structure, impact, and hardness tests, it was decided that ITP 822 is a suitable chemical foaming agent. In addition, a weight reduction of 5.2 % was achieved. Moreover, the injection cycle time has been reduced by approximately 12 %, reducing the total cycle time from 35 s to 31 s.

Abstract The multi-target stool DNA (mt-sDNA) test screens for colorectal cancer (CRC) by analyzing DNA methylation/mutation and hemoglobin markers to algorithmically derive a qualitative result. A new panel of highly discriminant candidate methylated DNA markers (MDMs) was recently developed. Performance of the novel MDM panel, with hemoglobin, was evaluated in a simulated screening population using archived stool samples weighted to early-stage CRC and prospectively collected advanced precancerous lesions (APLs). Marker selection (MSS) and separate preliminary independent verification studies (VS) were conducted utilizing samples from multi-center, case-control studies. Sample processing included targeted MDM capture, bisulfite conversion, and MDM quantitation. Fecal hemoglobin was quantified using enzyme-linked immunosorbent assay. Samples were stratified into 75%/25% training-testing sets; model outcomes were cross-validated 1,000 times. All laboratory operators were blinded. The MSS included 232 cases (120 CRC/112 APLs) and 490 controls. The VS featured 210 cases (112 CRC/98 APLs) and 567 controls; APLs were 86.7% adenomas and 13.3% sessile serrated lesions (SSLs). Average age was 65.5 (cases) and 63.2 (controls) years. Mean sensitivity in the VS from cross-validation was 95.2% for CRC and 57.2% for APLs, with specificities of 89.8% (no CRC/APLs) and 92.4% (no neoplasia). Subgroup analyses showed CRC sensitivities of 93.4% (Stage I) and 94.2% (Stage II). APL sensitivity was 82.9% for high-grade dysplasia, 73.4% for villous lesions, 49.8% for tubular lesions, and 30.2% for SSLs. These data support high sensitivity and specificity for a next-generation mt-sDNA test panel. Further evaluation of assay performance will be characterized in a prospective, multicenter clinical validation study (NCT04144738).

Objective: The purpose of this retrospective case-controlled study was to examine the contribution of radiation therapy (RT) dose distribution on the development of significant CVD events in cancer patients within the previous 5 years. Methods: Patients receiving initial cancer and subsequent medical care at a large Southeastern medical center were culled from medical records and databases for a sample of 28 with and 28 without secondary CVD development. All demographic and clinical variables including CVD risk and outcome data were gleaned through medical record and billing review. The risk due to RT was isolated from known CVD risk factors present at the initiation of cancer treatment. Secondly, a novel means of applying dose volume histograms (DVHs) to summarize the radiation dose delivered to the heart and each of the three main coronary arteries was calculated by a medical physicist and radiation oncologist. Analysis used paired t-tests and Logistic Regression Modeling. Results: Case to control matching was made based upon age at cancer diagnosis [cases 62.29 +/- 8.9; controls: 61.93 +/- 9.0; (p=.571)]; gender; and cancer type. There were no significant differences between the RT dose statistics or delivery between pairs. A significant difference was observed with more cases having multiple risk factors at the time of cancer diagnosis: Cases had significantly higher BMIs (p=.009), systolic blood pressure (p=.028), glucose levels (p=.022), and calculated Framingham risk (w/BMI), (p=.001). More cases than controls were observed to have a history of CVD (McNemar’s p=.022), and diabetes (McNemar’s p=.003). No significant differences between cases and controls was observed for: ethnicity; marital status; comorbidities; smoking history; hyperlipidemia; alcohol abuse; chemotherapy type; nor use of hormone therapy. Conclusion: The cases all had significantly greater typical CVD risk factors upon cancer diagnoses and did not receive any greater or differing amounts of thoracic radiation. A logistic regression model revealed subjects with high systolic BP, CVD history and diabetes had much higher odds of being a CVD case. After accounting for these variables, no other radiation parameters (dose, DVH, nor shape) entered the model.

ImportanceDermatology is one of the least diverse specialties, while patients from minority racial and ethnic groups and other underserved populations continue to face numerous dermatology-specific health and health care access disparities in the US.ObjectivesTo examine the demographic characteristics and intended career goals of graduating US allopathic medical students pursuing careers in dermatology compared with those pursuing other specialties and whether these differ by sex, race and ethnicity, and/or sexual orientation.Design, Setting, and ParticipantsThis secondary analysis of a repeated cross-sectional study included 58 077 graduating allopathic medical students using data from the 2016 to 2019 Association of American Medical Colleges Graduation Questionnaires.Main Outcomes and MeasuresThe proportion of female students, students from racial and ethnic groups underrepresented in medicine (URM), and sexual minority (SM) students pursuing dermatology vs pursuing other specialties. The proportions and multivariable-adjusted odds of intended career goals between students pursuing dermatology and those pursuing other specialties and by sex, race and ethnicity, and sexual orientation among students pursuing dermatology.ResultsA total of 58 077 graduating students were included, with 28 489 (49.0%) female students, 8447 (14.5%) URM students, and 3641 (6.3%) SM students. Female students pursuing dermatology were less likely than female students pursuing other specialties to identify as URM (96 of 829 [11.6%] vs 4760 of 27 660 [17.2%]; P &amp;lt; .001) or SM (16 [1.9%] vs 1564 [5.7%]; P &amp;lt; .001). In multivariable-adjusted analyses, students pursuing dermatology compared with other specialties had decreased odds of intending to care for underserved populations (247 of 1350 [18.3%] vs 19 142 of 56 343 [34.0%]; adjusted odd ratio [aOR], 0.40; 95% CI, 0.35-0.47; P &amp;lt; .001), practice in underserved areas (172 [12.7%] vs 14 570 [25.9%]; aOR, 0.40; 95% CI, 0.34-0.47; P &amp;lt; .001), and practice public health (230 [17.0%] vs 17 028 [30.2%]; aOR, 0.44; 95% CI, 0.38-0.51; P &amp;lt; .001) but increased odds of pursuing research (874 [64.7%] vs 29 121 [51.7%]; aOR, 1.76; 95% CI, 1.57-1.97; P &amp;lt; .001) in their careers. Among students pursuing dermatology, female, URM, and SM identities were independently associated with increased odds of caring for underserved populations (eg, URM: aOR, 4.05; 95% CI, 2.83-5.80) and practicing public health (eg, SM: aOR, 2.55; 95% CI, 1.51-4.31). URM students compared with non-URM students pursuing dermatology had increased odds of intending to practice in underserved areas (aOR, 3.93; 95% CI, 2.66-5.80), and SM students compared with heterosexual students pursuing dermatology had increased odds of intending to become medical school faculty (aOR, 1.60; 95% CI, 1.01-2.57), to pursue administrative roles (aOR, 1.60; 95% CI, 1.01-2.59), and to conduct research (aOR, 1.73; 95% CI, 1.01-2.98).Conclusions and RelevanceThe findings of this cross-sectional study suggest that diversity gaps continue to exist in the dermatology workforce pipeline. Efforts are needed to increase racial and ethnic and sexual orientation diversity and interest in careers focused on underserved care and public health among students pursuing dermatology.

Abstract Funding Acknowledgements Type of funding sources: None. BACKGROUND Upgrade to resynchronization therapy (CRT) is common practice in Europe. However, guideline recommendations are discordant and randomized trials are lacking. Previous studies have shown worse outcomes in upgraded patients. AIM To compare clinical outcomes in a cohort of patients receiving de novo or upgrade to CRT. METHODS Single-center retrospective study of consecutive patients submitted to CRT implantation (2007-2018). Major adverse cardiac events (MACE) included heart failure hospitalization or all-cause mortality. Clinical response was defined as NYHA class improvement without MACE in the 1st year of follow-up (FU). Left ventricle end-systolic volume reduction of &gt;15% designated echocardiographic (echo) response. Survival analysis with Kaplan-Meier method and Log-rank test was performed. Propensity-score matching (PSM) analysis was performed to adjust for possible confounder variables. RESULTS 295 CRT patients (70.5% male, mean age 67 ± 11 years, 72.5% non-ischemic cardiomyopathy, 54.6% implanted with CRT-D) were included. Fifty-six patients (19%) underwent an upgrade: 43 (78.2%) from a pacemaker and 12 (21.8%) from a defibrillator device. Indications for upgrade were mainly pacemaker dependency or pacing-induced LV dysfunction (76.6%) and de novo left bundle branch block (23.4%). Upgraded patients were older (70 vs 66 years, p=.034), with larger baseline QRS (185 ± 25 vs 163 ± 30 ms, p&lt;.001) and higher rates of atrial fibrillation (58.2% vs 26.7%, p&lt;.001), coronary artery disease (41.8% vs 26.2%, p=.033), moderate to severe valve disease (42.9% vs 22.6%, p=.003) and chronic kidney disease (36.4% vs 18.7%, p=.008). Upgraded patients more frequently received CRT-P (71.4% vs 39.3%, p&lt;.001). CRT-D were more often implanted for secondary prevention (53.3% vs 20.2%, p=.011) in the upgrade group. There were no differences in procedural complications, clinical (59.3 vs 62.6%, p=.765) or echo (72.2% vs 71.9%, p=.970) response rates. During a median FU of 3 ± 5 years, all-cause mortality was similar among groups (Log-rank test, p=.688). MACE occurred more frequently in the upgrade group (Log-rank test, p=.025). No differences emerged in lead complications (8.9% vs 8.4%, p=.892) or device infection (1.8% vs 2.9%, p=.986). PSM analysis identified 106 matched pairs (56 upgrade/50 de novo patients), without baseline statistical differences. All-cause mortality (Log-rank test, p=.555) and MACE (Log-rank test, p=.574) were comparable between groups. CONCLUSION In this cohort, upgrade to CRT was comparable to de novo implantation in terms of clinical and echo response. Moreover, upgrade to CRT was not associated with higher complication rates. All-cause mortality and MACE were similar between groups.