Log in

Relevant bibliographies by topics / [556 / Journal articles

To see the other types of publications on this topic, follow the link: [556.

Journal articles on the topic '[556'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 May 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic '[556.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

OHKAWA, K., M. HADA, and H. NAKATSUJI. "Excited states of four hemes in a c-type cytochrome subunit of the photosynthetic reaction center of Rhodopseudomonas viridis: SAC-CI calculations." Journal of Porphyrins and Phthalocyanines 05, no. 03 (March 2001): 256–66. http://dx.doi.org/10.1002/jpp.311.

Full text

Abstract:

The excited states of four hemes, c-552, c-554, c-556, and c-559, in a c-type cytochrome subunit of the photosynthetic reaction center (PSRC) of Rhodopseudomonas (Rps.) viridis were studied using the symmetry-adapted cluster (SAC)-configuration interaction (CI) method. c-552 has two imidazole ligands, while the other three hemes have imidazole and methionine ligands. The electronic states of these four hemes are affected significantly by both the ligands and protein and water environments. The ligand effect classifies the four hemes into two groups, while the environmental effect is unique in each heme. The HOMO–LUMO energy separation of c-552 is much smaller than those of the other hemes, and therefore, the low-lying excited states of c-552 are more stable than those of the other hemes. The low-lying excited states and their oscillator strengths of c-559 are significantly modified by the environment when compared with c-556 and c-554. Some observed UV peaks of the PSRC of Rps. viridis were found to have been assigned reasonably to the excited states of these four hemes in a previous report. The calculated linear dichroism angles also supported our assignment.

APA, Harvard, Vancouver, ISO, and other styles

2

Мельник, Виктор. "ПЕРВЫЙ ФРАНКО-ВИЗАНТИЙСКИЙ КОНФЛИКТ: АНАЛИЗ СОБЫТИЙ 550-х гг." Аннали юридичної історії (The Annals of Legal History) 3, no. 3-4 (December 2019): 51–67. http://dx.doi.org/10.38129/ann.yur.ist.2019.3.3.4.51.

Full text

Abstract:

Статья посвящена истории франкско-византийского конфликта 552-556 гг., произошедшего на фоне ослабления Италии – провинции Восточной Римской империи. В 553-554 гг. на территорию Италии вторглись алеманны, бургунды и франки под руководством франкских военачальников. Автор доказывает осведомленность франкского короля об этой акции и подчеркивает разрушительный характер неудачной попытки экспансии со стороны династии Меровингов. Ключевые слова: Восточная Римская империя (Византия), Италия, Нарсес, остготы, франки, династия Меровингов.

APA, Harvard, Vancouver, ISO, and other styles

3

Ciske, P., B. Franklin, S. Gordon, and G. C. Timmis. "556." Medicine & Science in Sports & Exercise 19, Supplement (April 1987): S93. http://dx.doi.org/10.1249/00005768-198704001-00556.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Forbes, Michael, and Rohin Vij. "556." Critical Care Medicine 41 (December 2013): A135—A136. http://dx.doi.org/10.1097/01.ccm.0000439798.04051.a7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Sullivan, Kevin, A. Shaun Rowe, and Leslie Hamilton. "556." Critical Care Medicine 42 (December 2014): A1493—A1494. http://dx.doi.org/10.1097/01.ccm.0000458053.85084.e1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Kastner, Kathleen, Masha Kocherginsky, Karla Garcia-Huerta, Christopher Mattson, Neethi Pinto, and Michael Msall. "556." Critical Care Medicine 43 (December 2015): 140–41. http://dx.doi.org/10.1097/01.ccm.0000474384.81546.25.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Smith, Gerald A. "556." Medicine & Science in Sports & Exercise 43, Suppl 1 (May 2011): 7. http://dx.doi.org/10.1249/01.mss.0000402688.51332.e3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Puzniak, Laura, Rao Fu, Jake Gundrum, and Thomas Lodise. "556." Critical Care Medicine 47 (January 2019): 258. http://dx.doi.org/10.1097/01.ccm.0000551308.61439.70.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Janiczek, Jonathan, Patrick Coppler, Dan Winger, Alexa Sabedra, Jon Rittenberger, Joshua Reynolds, and Cameron Dezfulian. "556." Critical Care Medicine 40 (December 2012): 1–328. http://dx.doi.org/10.1097/01.ccm.0000424774.47534.ab.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Wise, Celeste, and Richard Chan. "556." Critical Care Medicine 48 (January 2020): 259. http://dx.doi.org/10.1097/01.ccm.0000625968.68780.aa.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Rizza, A., Z. Ricci, C. Iacoella, C. Pezzella, R. Haiberger, and P. Cogo. "ABSTRACT 556." Pediatric Critical Care Medicine 15 (May 2014): 127. http://dx.doi.org/10.1097/01.pcc.0000449282.54500.66.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Lehl, K., L. Pitzer, W. B. Schoolcraft, and J. M. Stevens. "P-556." Fertility and Sterility 86, no. 3 (September 2006): S340—S341. http://dx.doi.org/10.1016/j.fertnstert.2006.07.925.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Shlendov, Igor'. "Energy Unit Expenses of Trains with Asynchronous Electric Drive." Bulletin of scientific research results, no. 1 (March 30, 2022): 118–28. http://dx.doi.org/10.20295/2223-9987-2022-1-118-128.

Full text

Abstract:

Objective: The assessment of energy effectiveness of traction drives for carriages of rolling stock models 81-765/766/767 and 81-556/557/558 (“NEVA”) from various producers and drafting technical requirements for drive electric equipment. Stock 81-765/766/767 uses asynchronous engine of 170 kW wattage and 43 Hz field rated frequency, 81-556/557/558 — 167 kW with 70 Hz rated frequency. Methods: The comparative analysis of drive energy indicators of trains with asynchronous electric drives has been accomplished in accordance with the calculation methodology. Measuring section was set in accordance with GOST P 50850-96. There are defined the assumptions at motion of rolling stock with equal maximal acceleration in a runaway and maximal deceleration in a braking and constant deceleration in a run-out. Maximal acceleration and deceleration were calculated incompliance adhesion set coefficient, grip weight (mass of motor cars) and moment of inertia. The calculation by method of analytical integration of motion differential equation was held on runaway five intervals. Initial technical data of trains with rated load as well as calculated indicators at train motion on measuring section were accepted. Diagrams of train motion on section were built and comparative analysis of characteristics of stock carriage models 81-765/766/767 and 81-556/557/558 (“NEVA”) was pursued. Results: It was established during the comparison that engine overload by torque on shaft is the same with 1.5 coefficient to rated torque. Stocks have significantly different indicators as by unit expenses as well as by motion dynamics. It’s been also established that for to minimize energy costs for traction it’s required to develop maximally allowable deceleration at braking and maximally allowable acceleration at runaway. Practical importance: The necessity of entry into Technical Task for new rolling stock of the requirement on stock check on runaway possibility with maximal set acceleration.

APA, Harvard, Vancouver, ISO, and other styles

14

Malhotra, A., B. Lakin, and L. Tume. "Abstract P-556." Pediatric Critical Care Medicine 19 (June 2018): 220–21. http://dx.doi.org/10.1097/01.pcc.0000538013.69764.ea.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Cribb, Phillip, and Kathleen King. "556. Polystachya Longiscapa." Curtis's Botanical Magazine 23, no. 2 (May 2006): 153–56. http://dx.doi.org/10.1111/j.1355-4905.2006.00524.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

. "556 Financiering Opleidingsfonds." Zorg en Financiering 5, no. 4 (April 2006): 102. http://dx.doi.org/10.1007/bf03092380.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Gross, Michael L., Nina Soberman, Howard D. Dorfman, and Leonard P. Seimon. "Case report 556." Skeletal Radiology 18, no. 5 (August 1989): 389–91. http://dx.doi.org/10.1007/bf00361432.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Khatib, H. A., and A. G. Karseras. "With regards to ‘Endophthalmitis’ (Editorial, Eye 2004, 18, 555–556)." Eye 20, no. 5 (July 1, 2005): 627. http://dx.doi.org/10.1038/sj.eye.6701980.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Editor, El. "Enero-febrero." ECA: Estudios Centroamericanos 50, no. 555-556 (February 28, 1995): 117–31. http://dx.doi.org/10.51378/eca.v50i555-556.5952.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

M., A. "El movimiento social y la privatización." ECA: Estudios Centroamericanos 50, no. 555-556 (February 28, 1995): 93–95. http://dx.doi.org/10.51378/eca.v50i555-556.5944.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

De la UCA, Instituto de Derechos Humanos. "El plan económico, ¿es bueno o malo?" ECA: Estudios Centroamericanos 50, no. 555-556 (February 28, 1995): 105–11. http://dx.doi.org/10.51378/eca.v50i555-556.5950.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

P., R. A. "Consideraciones políticas sobre el plan económico del gobierno." ECA: Estudios Centroamericanos 50, no. 555-556 (February 28, 1995): 96–99. http://dx.doi.org/10.51378/eca.v50i555-556.5945.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

L., F. J. "Releyendo la plataforma económica." ECA: Estudios Centroamericanos 50, no. 555-556 (February 28, 1995): 87–92. http://dx.doi.org/10.51378/eca.v50i555-556.5943.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

G., L. A. "El nacionalismo latinoamericano en los umbrales del siglo XXI." ECA: Estudios Centroamericanos 50, no. 555-556 (February 28, 1995): 112–16. http://dx.doi.org/10.51378/eca.v50i555-556.5951.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Cañas, UCA, Universidad Centroamericana "José Simeón. "Las fuerzas antidemocráticas amenazan la transición." ECA: Estudios Centroamericanos 50, no. 555-556 (February 28, 1995): 5–11. http://dx.doi.org/10.51378/eca.v50i555-556.5913.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Editor, El. "Septiembre y octubre de 1994." ECA: Estudios Centroamericanos 50, no. 555-556 (February 28, 1995): 133–37. http://dx.doi.org/10.51378/eca.v50i555-556.5953.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

G., L. A. "Enero." ECA: Estudios Centroamericanos 50, no. 555-556 (February 28, 1995): 100–104. http://dx.doi.org/10.51378/eca.v50i555-556.5949.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Editor, El. "El proceso cuestionado ; La nueva política económica." ECA: Estudios Centroamericanos 50, no. 555-556 (February 28, 1995): 141–58. http://dx.doi.org/10.51378/eca.v50i555-556.5954.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Editor, El. "La mejor política económica es la del bien común." ECA: Estudios Centroamericanos 50, no. 555-556 (February 28, 1995): 13–23. http://dx.doi.org/10.51378/eca.v50i555-556.5914.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

정재훈. "The Organization of Türk State in the Early Period (552~556)." CENTRAL ASIAN STUDIES 19, no. 1 (June 2014): 61–89. http://dx.doi.org/10.29174/cas.2014.19.1.003.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Dent, B., A. Immanuel, and SM Griffin. "Minimally invasive endoscopic therapy for the management of Boerhaave’s syndrome." Annals of The Royal College of Surgeons of England 96, no. 3 (April 2014): 253–54. http://dx.doi.org/10.1308/003588414x13814021678754.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Fan, Chunxiong, Yanping Deng, Yaqing Liu, Xiaoying Liu, Xi Ke, Cuiyun Zhou, and Xiufeng Wu. "mir-556-3p Promotes the Progression of Breast Cancer Through Targeting Disabled Gene Homolog 2 Interacting Protein (DAB2IP)." Journal of Biomaterials and Tissue Engineering 11, no. 12 (December 1, 2021): 2472–77. http://dx.doi.org/10.1166/jbt.2021.2848.

Full text

Abstract:

Our study assessed miR-556-3p’s role in breast cancer cells. A total of 65 cases of breast cancer tissue samples were retrospectively analyzed to detect miR-556-3p level by PCR and analyze survival time and 30 normal breast tissues were included as a control group. Breast cancer cells were cultured followed by analysis of cell proliferation by MTT, cell invasion by transwell assay. miR-556-3p level was significantly upregulated in breast cancer patients compared to control group (P <0.05) and inversely associated with survival rate (P <0.05). In vitro experiments, cell activity and invasion were positively correlated with miR-556-3p level (P <0.05). In MCF-7 cell lines, miR-556-3p overexpression increased cell activity (P <0.05). Meanwhile, after miR-556-3p was overexpressed, the expression of DAB2IP, Erk, p-Erk in breast cancer cells was significantly reduced and increased after miR-556-3p was knocked down. In conclusion, miR-556-3p targets DAB2IP3′-UTR, promotes breast cancer cell proliferation, indicating that miR-556-3p might be involved in breast cancer pathogenesis and may be a new target for the treatment.

APA, Harvard, Vancouver, ISO, and other styles

33

MANICKAM, B., A. PERLAS, E. DUGGAN, V. CHAN, and R. RAMLOGAN. "556: Ultrasound Guided Saphenous Nerve Block." Regional Anesthesia and Pain Medicine 33, no. 5 (September 2008): e86-e86. http://dx.doi.org/10.1016/j.rapm.2008.07.174.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Cutler, N. R., and J. J. Sramek. "556 What is the bridging study?" Neurobiology of Aging 17, no. 4 (January 1996): S138. http://dx.doi.org/10.1016/s0197-4580(96)80558-6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Manickam, B., A. Perlas, E. Duggan, V. Chan, and R. Ramlogan. "556. Ultrasound Guided Saphenous Nerve Block." Regional Anesthesia & Pain Medicine 33, Suppl 1 (September 2008): e86.1-e86. http://dx.doi.org/10.1136/rapm-00115550-200809001-00162.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

YOUNG, M., and C. DELISE. "556 Estrogen (E) hypersensitivity and desensitization." Journal of Allergy and Clinical Immunology 87, no. 1 (January 1991): 278. http://dx.doi.org/10.1016/0091-6749(91)91839-l.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

. "556 Invoering Prestatiebekostiging Ziekenhuizen Moet Zorgvuldig." Zorg en Financiering 7, no. 5 (May 2008): 67–68. http://dx.doi.org/10.1007/bf03096792.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Yoshimura, Kazuhisa, Shigeyoshi Harada, Junji Shibata, Makiko Hatada, Yuko Yamada, Chihiro Ochiai, Hirokazu Tamamura, and Shuzo Matsushita. "Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds." Journal of Virology 84, no. 15 (May 26, 2010): 7558–68. http://dx.doi.org/10.1128/jvi.00227-10.

Full text

Abstract:

ABSTRACT N-(4-Chlorophenyl)-N′-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamide (NBD-556) is a low-molecular-weight compound that reportedly blocks the interaction between human immunodeficiency virus type 1 (HIV-1) gp120 and its receptor CD4. We investigated whether the enhancement of binding of anti-gp120 monoclonal antibodies (MAbs) toward envelope (Env) protein with NBD-556 are similar to those of soluble CD4 (sCD4) by comparing the binding profiles of the individual MAbs to Env-expressing cell surfaces. In flow cytometric analyses, the binding profiles of anti-CD4-induced epitope (CD4i) MAbs toward NBD-556-pretreated Env-expressing cell surfaces were similar to the binding profiles toward sCD4-pretreated cell surfaces. To investigate the binding position of NBD-556 on gp120, we induced HIV-1 variants that were resistant to NBD-556 and sCD4 in vitro. At passage 21 in the presence of 50 μM NBD-556, two amino acid substitutions (S375N in C3 and A433T in C4) were identified. On the other hand, in the selection with sCD4, seven mutations (E211G, P212L, V255E, N280K, S375N, G380R, and G431E) appeared during the passages. The profiles of the mutations after the selections with NBD-556 and sCD4 were very similar in their three-dimensional positions. Moreover, combinations of NBD-556 with anti-gp120 MAbs showed highly synergistic interactions against HIV-1. We further found that after enhancing the neutralizing activity by adding NBD-556, the contemporaneous virus became highly sensitive to antibodies in the patient's plasma. These findings suggest that small compounds such as NBDs may enhance the neutralizing activities of CD4i and anti-V3 antibodies in vivo.

APA, Harvard, Vancouver, ISO, and other styles

39

Farrokhyar, Forough, Kevin McHugh, and E. Jan Irvine. "Self-Reported Awareness and Use ofInternational Classification of DiseaseCoding of Inflammatory Bowel Disease Services by Ontario Physicians." Canadian Journal of Gastroenterology 16, no. 8 (2002): 519–26. http://dx.doi.org/10.1155/2002/619574.

Full text

Abstract:

RATIONALE: Population and health services research can be performed by linkage analysis of administrative data. However, the robustness of study results is determined by the accuracy of the diagnostic coding.OBJECTIVES: To estimate the awareness, use and accuracy of theInternational Classification of Diseases, Ninth Revision(ICD-9) coding by physicians providing services for patients with Crohn’s disease (CD) and ulcerative colitis (UC).METHODS: All Ontario gastroenterologists and a 10% random sample of internists, pediatricians, pediatric or general surgeons, and family physicians were surveyed by postal questionnaire to estimate the frequency and 95% CI of using codes 555 or 556 when billing for CD- and UC-related services, respectively.Χ2tests were used for between-group comparisons.RESULTS: Of the physicians who were surveyed, 67.7% (416 of 614) responded; 258 of 391 (66%) who were still practising in Ontario saw patients with inflammatory bowel disease (IBD), and 54% had more than 10 IBD patients; 86.5% (95% CI 82.4% to 90.6%) were familiar with ICD-9 codes, and 91.4% (95% CI 88.1% to 95.6%) used the codes 555 (CD) or 556 (UC) for billing. Rates of ICD-9 use did not differ by sex but were used more frequently by those graduating after 1981 (P<0.02). Gastroenterologists used ICD-9 IBD codes 555 or 556 significantly more often than all other physicians (P=0.001). Most (more than 75%) Ontario physicians used ICD-9 IBD codes always or frequently when billing for IBD-related services. Few (10%) used these codes to bill for non-IBD-related problems.CONCLUSIONS: These data suggest that there is acceptable use and accuracy of ICD-9 diagnostic coding for CD and UC services – comparable with results from studies of other diseases. Administrative data may thus be used to undertake epidemiological studies in IBD in Ontario.

APA, Harvard, Vancouver, ISO, and other styles

40

Gómez, Rivas J., Y. Gregorio S. Alonso, Sánchez D. López, Viver J. Pons, Gómez A. Tabernero, Ledo J. Cisneros, and Barthel J. J. De La Peña. "556 Iatrogenic ureteral stricture: Laparoscopic ureteral reimplantation." European Urology Supplements 12, no. 1 (March 2013): e556. http://dx.doi.org/10.1016/s1569-9056(13)61039-8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Kammoun, M., R. Hichri, H. Hannechi, S. Mechmech, D. Hmida, M. Bibi, A. Saad, and S. Mougou. "556 Igf1R Deletion in a Prenatal Case." Archives of Disease in Childhood 97, Suppl 2 (October 1, 2012): A162. http://dx.doi.org/10.1136/archdischild-2012-302724.0556.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

. "556 Europese Classificatie Rijveiligheid Medicijnen Op Komst." Zorg en Financiering 6, no. 4 (April 2007): 117–18. http://dx.doi.org/10.1007/bf03093848.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Van Doren, Jane M., William M. Foley, Joseph E. McClellan, Thomas M. Miller, Albert D. Kowalak, and A. A. Viggiano. "Electron attachment to haloacetonitriles, 295–556 K." International Journal of Mass Spectrometry and Ion Processes 149-150 (November 1995): 423–28. http://dx.doi.org/10.1016/0168-1176(95)04273-n.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Cai, Yini, Ming Fang, GongJi Yao, Lingmin Liao, and Long Huang. "Mir-556-3p Inhibits SqCLC via NUAK1." International Journal of Surgery: Oncology 7, no. 1 (2022): 30–45. http://dx.doi.org/10.29337/ijsonco.138.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Milléo, Julianne, and Lúcia Massutti de Almeida. "Revision of the Genus Tiphysa Mulsant (Coleoptera, Coccinellidae, Hyperaspidinae)1." Coleopterists Bulletin 57, no. 3 (September 2003): 274–80. http://dx.doi.org/10.1649/556.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Science Institute, Informing. "Introduction to the Special Series on Widening the Focus." Informing Science: The International Journal of an Emerging Transdiscipline 4 (2001): 045–46. http://dx.doi.org/10.28945/556.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Berardinelli, Daniel Antonio. "Federación Argentina de Asociaciones Regionales de Ortopedia y Traumatología para el Ejercicio Profesional. (FAAOTEP)." Revista de la Asociación Argentina de Ortopedia y Traumatología 80, no. 4 (November 19, 2015): 229. http://dx.doi.org/10.15417/556.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Emile, Jean-François, Isabelle Ray-Coquard, Binh Bui, Antoine Adenis, François Bertucci, Florence Duffaud, Didier Cupissol, et al. "Relationship of the topography of KIT exon 11 alterations and predictive value for PFS in patients with advanced GIST: Results of the BFR14 prospective French Sarcoma Group randomized phase III trial." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): 10542. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.10542.

Full text

Abstract:

10542 Background: The mutations of KIT exon 11 are those most frequently observed in GIST, but there is a substantial level of heterogeneity in their nature and topography. We investigated the impact of the type of KIT exon 11 mutations on clinical presentation and outcome under imatinib in advanced GIST patients (pts) included in the BFR14 study. Methods: Among the 434 pts included, 167 were identified as having GIST with KIT exon 11 mutation (85% of all KIT mutations and 73% of all mutations available in the entire cohort). We analyzed the topography of the mutations and identified 3 groups (G) of mutations according to the first codon involved in the genetic alteration in which the precise topography was available (from codon 549 to 579). The distribution of these G in the different clinical presentations was investigated, as well as their predictive value for progression-free (PFS) and overall survival (OS). Results: Three G with distinct sites of altered codons were distinguished: G1 whose 1st mutated codon was <556 (n=41, 24.5%), G2 whose 1st mutated codon was 557 and 558 (n=74, 44.3%), including those with the deletion 557-558 (n=37, 22.1%), and G3 whose 1stmutated codon was 559 and beyond (n=52, 31.1%). All investigated parameters at inclusion, gender, tumor site and size, site of metastases, age, PS, CD34 expression, biological characteristics were well balanced between the three G of patients. Pts of G2 reached a statistically difference in terms of complete response under imatinib (p=0.028). In contrast, this G have the poorer PFS compared to the other two groups: the median PFS were 30.6 months (CI95%: 21.5;39.4), 49.4 months (CI95%: 33.5; 109.9) and 63.3 months (CI95%: 27.6; 84.7) for the G 2, 1 and 3 respectively (p=0.0176). OS was not significantly different in the 3 G of pts. Conclusions: Despite a favorable sensitivity to imatinib, GIST pts harbouring a genetic alteration initially involving the 557 and 558 codons develop statistically more secondary resistance than the others. These results deserve confirmation in other prospective series in advanced GIST and may be worth exploring in adjuvant series.

APA, Harvard, Vancouver, ISO, and other styles

49

Issaoui, Z., S. Joobeur, N. Skhiri, S. Saadaoui, N. Zaatir, R. Saad, M. H. Battikh, N. Rouetbi, and A. El Kamel. "66 L’asthme aux acariens : revue de 556 cas." Revue des Maladies Respiratoires 24 (January 2007): 33. http://dx.doi.org/10.1016/s0761-8425(07)72442-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Khalfa, S., E. Veuillet, and L. Collet. "556 Influence of handedness on peripheral auditory asymmetry." International Journal of Psychophysiology 30, no. 1-2 (September 1998): 212–13. http://dx.doi.org/10.1016/s0167-8760(98)90555-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!