Relevant bibliographies by topics / 5 Rs de radiobiologie

Academic literature on the topic '5 Rs de radiobiologie'

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Published: 7 July 2024

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Journal articles on the topic "5 Rs de radiobiologie":

1

Brown, J. Martin, David J. Carlson, and David J. Brenner. "The Tumor Radiobiology of SRS and SBRT: Are More Than the 5 Rs Involved?" International Journal of Radiation Oncology*Biology*Physics 88, no. 2 (February 2014): 254–62. http://dx.doi.org/10.1016/j.ijrobp.2013.07.022.

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Ollevier, Thierry, Jean-Emmanuel Bouchard, Valerie Desyroy, and Christian Tessier. "(RS,RS)-5-[Hydroxy(4-methylphenyl)methyl]furan-2(5H)-one." Acta Crystallographica Section E Structure Reports Online 63, no. 11 (October 12, 2007): o4298. http://dx.doi.org/10.1107/s1600536807048817.

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The crystal structure of the racemic title compound, C12H12O3, allowed the determination of the relative configuration at the two stereogenic centers. For the R,R isomer, the O—C—C—O and C—C—C—C torsion angles around the bond between the two methine C atoms are 62.38 (15) and −175.49 (13)°, respectively. The furan and tolyl groups are almost perpendicular, with a dihedral angle of 79.39 (5)°. Strong and linear intermolecular O—H...O hydrogen bonding (H...O = 2.04 Å and O—H...O = 177°) is observed between the hydroxyl group and the C=O oxygen.
3

Miller, Dave P., Valentina I. Petkov, and Steven Shak. "The performance of the 21-gene assay standard cutpoints of 18 and 31 in HR+, HER2- invasive breast cancer (BC), while waiting for TAILORx mid-range recurrence score results." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): 537. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.537.

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537 Background: The Recurrence Score (RS) was shown in NSABP B-20 to predict chemotherapy (CT) benefit for RS ≥31 and no CT benefit for RS <18. The TAILORx results for RS <11 (NEJM 2015) reported excellent outcomes with no opportunity for CT to add additional benefit. As we await TAILORx results for RS 11-25, we characterized BC specific mortality (BCSM) for RS groups (cutoffs of 11, 18, 25, and 31) in the population-based SEER study of pts treated based on RS. Methods: RS results were provided to SEER registries per their methods (npj Breast Cancer 2016). Pts diagnosed (Jan 2004 - Dec 2012) with N0 HR+ HER2- negative BC, and no prior malignancy were eligible. BCSM estimates by CT use were computed using standard cutpoints of 18 and 31 and TAILORx cutpoints of 11 and 25. Results: Among 49,681 with a RS, 9,486 (19%) had RS <11, 17,988 (36%) had RS 11-17, 14,541 (29%) had RS 18-25, 3,805 (8%) had RS 26-30, and 3,861 (8%) had RS ≥31. Reported CT use and 5-y BCSM increased with increasing RS. For pts with both RS <11 and RS 11-17, CT use was uncommon and 5-y BCSM was low regardless of CT use. For pts with RS 18-25, CT use was more common and the 5-y BCSM was about 1% regardless of CT use. For pts with RS of 26-30 or ≥31, CT was common, and lower 5-y BCSM was observed with CT reported yes than with CT reported no or unknown. Conclusions: Pts in real-world clinical practice with RS <11, consistent with TAILORx, and pts with RS 11-17 have low 5-y BCSM with limited CT use, supporting hormonal therapy alone for pts with RS <18. The high end of the TAILORx mid-range (18-25) also showed good 5-y BCSM both with and without CT, highlighting the importance of the randomized results of TAILORx. [Table: see text]
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Komrokji, Rami S., John Barnard, David P. Steensma, Amy E. DeZern, Gail J. Roboz, Najla Alali, Jaime Fensterl, Guillermo Garcia-Manero, and Mikkael A. Sekeres. "Ring Sideroblasts and SF3B1 Mutations in Myelodysplastic Syndromes (MDS): Are They Two Faces of the Same Coin? a Study on Behalf of the MDS Clinical Research Consortium (MDS CRC)." Blood 128, no. 22 (December 2, 2016): 4321. http://dx.doi.org/10.1182/blood.v128.22.4321.4321.

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Abstract Introduction Recurrent somatic mutations in SF3B1, a gene encoding a spliceosome component, have been identified in patients (pts) with myelodysplastic syndromes (MDS). SF3B1 mutations (MT) are more commonly detected in pts with ring sideroblast (RS) morphology and are associated with favorable outcome. The proposed 2016 World Health Organization (WHO) MDS classification categorizes pts with >5% RS and SF3B1 MT as MDS with RS, in contrast to prior WHO classifications which required ≥15% RS regardless of genotype. In this study, we explored the prognostic value of RS and SF3B1 MT and assessed the validity of the new proposal. Methods We identified 471 pts with MDS and known SF3B1 mutational status from MDS CRC institutions. RS were assessed as present or absent (RS +/-) based on bone marrow aspirate reports (n=157); in cases where quantitative data on RS% were available (n=41), pts were grouped in the 5-15% RS group or > 15% RS group. Survival was calculated from time of diagnosis. Cox regression analysis was used to estimate hazard ratios for overall survival (OS) and AML free survival (AFS), which was defined as time to death or AML transformation, respectively. Chi-squared and Wilcoxon tests were used to test for differences in categorical and continuous distributions, respectively. Results: Among 471 pts with known SF3B1 mutational status, 76 (16%) had MT. Pts with MT had lower-risk International Prognostic Scoring System (IPSS) scores compared to SF3B1 wild-type (WT; 79% vs 57%, p < .001). Among pts with MT, 50% had RS + compared to 19% RS + in the WT group (p < .001). MT were independently associated with better OS (HR 0.48, p= .001) and longer AFS (HR 0.5, p <.005) after adjusting for age and IPSS. We compared outcomes of four groups: WT/RS-, MT/RS-, WT/RS+, and MT/ RS +. Adjusting for age and IPSS, pts with MT/RS + had the best outcome, with hazard ratios for AFS of 4.2 for WT/RS- vs. MT/RS+ (p =.018), 4.1 for MT/RS- vs. MT/RS+ (p =.045), and 5.1 for WT/RS+ vs. MT/RS+ (p= .01). We compared 7 pts with 5-15% RS to 22 pts with >15% RS. Among patients with RS 5-15%, 4/7 pts (57%) were classified as MDS with excess blasts compared to 24% for those RS >15% (p=.09). Pts with 5-15% RS were more likely to be thrombocytopenic (5/7, 71%) compared to >15% RS (29%, p=.04). One patient (14%) with 5-15% RS had MT compared to 12 (55%) pts with > 15% RS, p= .06. In Cox regression analysis using the RS 5-15% group as the reference, the hazard ratio for RS > 15% for AFS was 0.26 (p = .034) and the hazard ratio for MT for AFS was 0.08 (p= .002). Conclusions SF3B1 somatic mutations in MDS are commonly associated with RS, better OS and longer AML-free survival. Patients with RS and MT had a significantly better outcome than those with either isolated RS or MT, or neither. These data support incorporation of SF3B1 mutation status into the WHO classification regardless of RS percent, though with differentiation for those with RS and MT. Disclosures Komrokji: Novartis: Consultancy, Speakers Bureau; Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding; Incyte: Consultancy; Boehringer-Ingelheim: Research Funding. Roboz:Cellectis: Research Funding; Agios, Amgen, Amphivena, Astex, AstraZeneca, Boehringer Ingelheim, Celator, Celgene, Genoptix, Janssen, Juno, MEI Pharma, MedImmune, Novartis, Onconova, Pfizer, Roche/Genentech, Sunesis, Teva: Consultancy.
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Wang, Jui-Ling, Yu-Siang Chen, Kuo-Chin Huang, Chin-Hsing Yeh, Miles Chih-Ming Chen, Lawrence Shih-Hsin Wu, and Yi-Han Chiu. "Resistant Starch-Encapsulated Probiotics Attenuate Colorectal Cancer Cachexia and 5-Fluorouracil-Induced Microbial Dysbiosis." Biomedicines 12, no. 7 (June 28, 2024): 1450. http://dx.doi.org/10.3390/biomedicines12071450.

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5-Fluorouracil (5-FU) is commonly used as the primary chemotherapy for colorectal cancer (CRC). However, it can lead to unwanted chemoresistance. Resistant starch (RS), which functions similarly to fermentable dietary fiber, has the potential to reduce the risk of CRC. The effects of RS on improving CRC-associated cachectic symptoms and 5-FU chemotherapy-induced microbial dysbiosis remain unknown. Female BALB/cByJNarl mice were randomly divided into four groups: one tumor group (with CT26 colonic carcinoma but no treatment) and three CT26 colonic carcinoma-bearing groups that were administered 20 mg/kg 5-FU (T+5-FU group), a probiotic cocktail (4 × 108 CFUs) plus chemotherapy (T+5-FU+Pro), or resistant-starch-encapsulated probiotics plus chemotherapy (T+5-FU+RS-Pro). T+5-FU and T+5-FU+RS-Pro administration significantly suppressed tumor growth and activated apoptotic cell death in CT26-bearing mice. 5-FU-induced increases in inflammatory cytokines and NF-κB signaling were mitigated by the Pro or RS-Pro supplementation. A gut microbial composition comparison indicated that the abundance of intestinal bacteria in the T and T+5-FU groups decreased significantly, while the groups receiving Pro or RS-Pro maintained a greater abundance and healthy gut microbiota composition, suggesting that RS can reduce the microbial dysbiosis that occurs during 5-FU chemotherapy. The use of RS-Pro before chemotherapy should be considered for the regulation of chemotherapy-associated cachectic symptoms, inflammation, and chemotherapy-induced microbial dysbiosis.
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Vallero, Daniel A., and Paul J. Lioy. "The 5 Rs: Reliable Postdisaster Exposure Assessment." Leadership and Management in Engineering 12, no. 4 (October 2012): 247–53. http://dx.doi.org/10.1061/(asce)lm.1943-5630.0000200.

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7

Park, Seok-Rae, Younghwan Han, Su Jeong Lee, and Ki-Il Lee. "Efficacy of Low-Level Laser Therapy in a Rabbit Model of Rhinosinusitis." International Journal of Molecular Sciences 24, no. 1 (January 1, 2023): 760. http://dx.doi.org/10.3390/ijms24010760.

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Little is known about alternative treatment options for rhinosinusitis (RS). We aimed to evaluate the efficacy of low-level laser therapy (LLLT) for RS in experimentally induced rabbit models of RS. A total of 18 rabbits were divided into four groups: a negative control group (n = 3), an RS group without treatment (n = 5, positive control group), an RS group with natural recovery (n = 5, natural recovery group), and an RS group with laser irradiation (n = 5, laser-treated group). Computed tomography and histopathological staining were performed for each group. mRNA and protein expression levels of local cytokines (IFN-γ, IL-17, and IL-5) were also measured. Tissue inflammation revealed a significant improvement in the laser-treated group compared with the RS and natural recovery groups (p < 0.01). In addition, sinus opacification in the CT scans and cytokine expression was reduced in the laser-treated group, though without statistical significance. LLLT could be an effective option for the management of RS concerning radiological, histological, and molecular parameters.
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Prabhakar, Pramod, Ram Pal Singh, Ramesh Pandey, Neeraj, and Anand Kumar Singh. "Evaluation of the repeatability of male calves' birth weights in different grades of Jersey x Red Sindhi crosses." EMERGENT LIFE SCIENCES RESEARCH 09, no. 02 (2023): 215–20. http://dx.doi.org/10.31783/elsr.2023.92215220.

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To assess the consistency of birth weight among male calves born to half-J x half-RS, quarter-J x ¾ RS, three-eighths Jersey x five-eighths RS, and one-eighth J x seven-eight RS cows. The SHUATS in Prayagraj, Uttar Pradesh, India obtained the data from a pedigree cum history sheet. Male calves born to 77 cows during the first (L1), second (L2), and third (L3) lactations, as well as 127 observations of Jersey x Red Sindhi cows of varying quality, were all measured and recorded in kilos. Increased reproducibility across many cross-breed dairy cow performance tiers indicates superiority. This research shows that choosing cows with higher estimations based on the birth weight. of their male calves can increase the output of herds. The mean of birth weight of male calves L1, L2, and L3 were 18.11, 20.15, 22.07 kg. of ½ J × ½ RS, 20.50, 19.88, 20.77 Kg f ¼ J × ¾ RS crosses, 20.06, 20.88, 22.24 kg. of 3/8 J × 5/8 RS, 19.08, 18.76, 22.83 kg of 1/8 J ×7/8 R.S proportionately. The ranges of birth weight of male calves from the Ist (L1), IInd (L2) and third (L3) lactations were 15.80 - 20.10, 15.80 - 26.6, 19.6 - 25.8 kg. of ½ J × ½ RS, 15.42 - 24.94, 14.51 - 25.70, 13.6 - 28.12 Kg. of ¼ J × ¾ R.S, 14.96 - 26.40, 16.32 - 24.30, 15.42 - 27.50 kg. of 3/8 J × 5/8 RS crosses, 15.87 - 24.23, 12.70 - 24.51, 18.14 - 25.80 kg. of 1/8 J ×7/8 RS respectively. The mean of birth weight of male calves was 20.13 kg. of ½ J × ½ RS, 17.68 Kg. of ¼ J × ¾ RS, 21.07 kg. of 3/8 J × 5/8 RS, 19.92 kg. of 1/8 J ×7/8 RS respectively. The highest birth weight of male calves were 25.8 Kg. and the lowest 15.80 Kg of ½ J × ½ R.S, 28.12 kg. highest and lowest 13.60 kg. of ¼ J × ¾ RS, 27.50 kg at highest and lowest 14.96 kg of 3/8 J × 5/8 RS, 25.8 kg at highest and lowest 12.70 kg. of 1/8 J ×7/8 RS, respectively. The repeatability of birth weight of male calves for 0.60 ± 0.20 of ½ J × ½ RS, 0.46 ± 0.19 of ¼ J × ¾ RS, 0.78 ± 0.15 of 3/8 J × 5/8 RS, 0.57 ± 0.15 of 1/8 J ×7/8 RS. The more repeatability for various grades of crossbred dairy cattle shows better performance.
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Rossi, Davide, Daniela Capello, Michaela Cerri, Clara Deambrogi, Stefania Cresta, Silvia Rasi, Valeria Spina, et al. "Molecular, Phenotypic and Clinical Predictors of Richter Syndrome (RS) in Chronic Lymphocytic Leukemia (CLL)." Blood 110, no. 11 (November 16, 2007): 3086. http://dx.doi.org/10.1182/blood.v110.11.3086.3086.

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Abstract RS occurs in 5–15% CLL, depending on follow-up length and re-biopsy policy. The value of biological and clinical risk factors in predicting RS is unknown and represents the aim of this study. The analysis was based on a consecutive series of 185 CLL. Diagnosis of RS was based on lymph node or extranodal tissue biopsy. RS was diagnosed in 17 cases all represented by diffuse large B-cell lymphoma (DLBCL). Cumulative incidence of RS at 5 and 10 years was 13.6% (95%CI: 7.0–20.1%) and 16.2% (95%CI: 8.0–24.4%), respectively. Transformation plateaued at 82 months of follow-up. Median time to transformation was 23.0 months (95%CI: 15.9–30.1 months) from CLL diagnosis. IGHV studies documented clonal relationship between CLL and DLBCL in 15/17 (88.2%) cases. At the time of CLL diagnosis, molecular variables predicting RS were: IGHV4–39 usage (5-year risk IGHV4-39: 56.2% vs IGHVnon-VH4-39: 11.2%; p<0.001), IGHV homology ≥98% (5-year risk IGHV homology ≥98%: 28.3% vs IGHV homology <98%: 7.0%; p=0.006), absence of del13q14 (5-year risk non-del13q14: 23.1% vs del13q14: 3.8%; p=0.006), and presence of +12 (5-year risk +12: 19.5% vs non +12 10.0%; p=0.027). CLL with p53 inactivation by p53 mutation and/or del17p13 had a trend toward an increased risk of transformation (5-year risk del17p13/p53 mutation: 24.6% vs non-del17p13/p53 mutation: 12.1%; p=0.061). Cluster analysis revealed that 6/17 (35.2%) CLL evolving to RS carried stereotyped CDR3s. Utilization of stereotyped IGHV4-39 or stereotyped IGHV1-2/1-3 predicted transformation (5-year risk stereotyped CDR3: 63.0%; p<0.001). Del11q22-q23, normal FISH katyotype, BCL2 C938A polymorphism, and telomere length did not predict RS. Among phenotypic markers at CLL diagnosis, expression of both CD38 (5-year risk CD38+: 25.4% vs CD38−: 4.7%; p<0.001) and ZAP70 (5-year risk ZAP70+ 27.9% vs ZAP70− 6.7%; p=0.002) predicted RS. At the time of CLL diagnosis, clinical variables predicting RS included: lymph node size ≥3 cm (5-year risk lymph node ≥3 cm: 49.1% vs lymph node <3 cm: 6.1%; p<0.001), involvement of 3 nodal areas (5-year risk 3 nodal areas: 31.8% vs nodal areas <2: 8.3%; p<0.001), Binet B stage (5-year risk Binet B: 40.8% vs Binet C 20% vs Binet A: 7.1%; p=0.003), and LDH ≥1.2 × ULN (5-year risk LDH >1.2 × ULN: 37.5% vs LDH <1.2 × ULN: 8.6%; p=0.001). Age, sex, Rai stage, splenomegaly, Hb, platelet count, percentage of BM lymphocytes, B2M, ALP, albumin and lymphocyte doubling time did not predict RS. Landmark analysis at 12, 24, 36, 48 and 60 months documented: a significantly increased risk of subsequent RS in progressive CLL vs stable CLL starting from 24 months; and no RS in stable CLL after 48 months of follow up. Multivariate analysis identified CD38 expression (HR 4.22, 95%CI 1.26–14.05; p= 0.019) and IGHV4-39 usage (HR 4.29, 95%CI 1.28–14.29; p=0.018) as biological predictors of RS, and lymph node ≥3 cm as clinical predictor of RS (HR 8.73, 95%CI 2.45–31.05; p=0.001). Our data suggest that RS is predicted by: predominant nodal disease at diagnosis; CD38 expression; and usage of specific IGHV genes, namely IGHV4-39. These results suggest the need for a close monitoring and a careful biopsy policy in patients with molecular, phenotypic and clinical predictors of RS identified at the time of CLL diagnosis.
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Wolmark, Norman, Eleftherios P. Mamounas, Frederick L. Baehner, Steven M. Butler, Gong Tang, Farid Jamshidian, Amy P. Sing, Steven Shak, and Soonmyung Paik. "Prognostic Impact of the Combination of Recurrence Score and Quantitative Estrogen Receptor Expression (ESR1) on Predicting Late Distant Recurrence Risk in Estrogen Receptor–Positive Breast Cancer After 5 Years of Tamoxifen: Results From NRG Oncology/National Surgical Adjuvant Breast and Bowel Project B-28 and B-14." Journal of Clinical Oncology 34, no. 20 (July 10, 2016): 2350–58. http://dx.doi.org/10.1200/jco.2015.62.6630.

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Purpose We determined the utility of the 21-Gene Recurrence Score (RS) in predicting late (> 5 years) distant recurrence (LDR) in stage I and II breast cancer within high and low-ESR1–expressing groups. Patients and Methods RS was assessed in chemotherapy/tamoxifen-treated, estrogen receptor (ER) –positive, node-positive National Surgical Adjuvant Breast and Bowel Project B-28 patients and tamoxifen-treated, ER-positive, node-negative B-14 patients. The association of the RS with risk of distant recurrence (DR) 0 to 5 years and those at risk > 5 years was assessed. An ESR1 expression cut point was optimized in B-28 and tested in B-14. Results Median follow-up was 11.2 years for B-28 and 13.9 years for B-14. Of 1,065 B-28 patients, 36% had low (< 18), 34% intermediate (18 to 30), and 30% high (≥ 31) RS. Of 668 B-14 patients, 51% had low, 22% intermediate, and 27% high RS. Median ESR1 expression by reverse transcriptase polymerase chain reaction was: B-28, 9.7 normalized expression cycle threshold units (CT) and B-14, 10.7 CT. In B-28, RS was associated with DR 0 to 5 years (log-rank P < .001) and > 5 to 10 years (log-rank P = .02) regardless of ESR1 expression. An ESR1 expression cut point of 9.1 CT was identified in B-28. It was validated in B-14 patients for whom the RS was associated with DR in years 5 to 15: 6.8% (95% CI, 4.4% to 10.6%) versus 11.2% (95% CI, 6.2% to 19.9%) versus 16.4% (95% CI, 10.2% to 25.7%) for RS < 18, RS 18 to 30, and RS ≥ 31, respectively (log-rank P = .01). Conclusion For LDR, RS is strongly prognostic in patients with higher quantitative ESR1. Risk of LDR is relatively low for patients with low RS. These results suggest the value of extended tamoxifen therapy merits evaluation in patients with intermediate and high RS with higher ESR1 expression at initial diagnosis.
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Dissertations / Theses on the topic "5 Rs de radiobiologie":

1

Hami, Abdoul-Azize Rihab. "Simulation des processus radiobiologiques basés sur l'imagerie pour l'évaluation de schémas thérapeutiques individualisés en radiothérapie." Electronic Thesis or Diss., Brest, 2024. http://www.theses.fr/2024BRES0002.

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La radiothérapie est l'un des principaux traitements du cancer. Malgré son utilisation intensive en pratique clinique, son efficacité dépend de plusieurs facteurs. Plusieurs études ont montré que la réponse tumorale à la radiothérapie diffère d'un patient à l'autre. En effet, la réponse de la tumeur est influencée par plusieurs facteurs comme l'hypoxie et des multiples interactions entre le microenvironnement tumoral et les cellules saines. Cinq concepts biologiques majeurs appelés les « 5 Rs » qui résument ces interactions ont vu le jour. Ces concepts incluent la réoxygénation, la réparation cellulaire, la redistribution cellulaire dans le cycle, la radiosensibilité intrinsèque et la repopulation tumorale. La stratégie de traitement optimale doit tenir compte de ces « 5 Rs ». Dans cette étude, nous avons proposé dans un premier temps une approche de modélisation d'oxygénation qui peut être considérée comme un processus d'optimisation de traitement en absence de données concernant l'oxygène. Nous avons utilisé un modèle multi-échelle afin de prédire les effets de la radiothérapie sur la croissance tumorale en utilisant une base des images de tomographie par émission de positons (PET). Ensuite, nous avons inclus dans notre modèle les «5 Rs » de la radiothérapie, afin de prédire les effets des rayonnements sur la croissance tumorale. Enfin, nous avons présenté une étude sur l'effet de différents types de fractionnement sur la réponse tumorale à la radiothérapie
Radiotherapy is one of the principal cancer treatments. Despite its intensive use in clinical practice, itseffectiveness depends on several factors. Several studies showed that the tumor response to radiotherapy differ from one patient to another. The response of tumor is influenced by several factors like hypoxia and multiple interactions between the tumor microenvironment and healthy cells. Five major biologic concepts called “5 Rs” resume these interactions. These concepts include reoxygenation, DNA damage-repair, cell cycle redistribution, cellular radiosensitivity and cellular repopulation.The optimal treatment strategy must consider these “5 Rs". In this study, we proposed as a first an approach to oxygenation modeling that can be considered as an optimization process in the absence of data concerning oxygen. We used a multi-scale model to predict the effects of radiotherapy on tumor growth based on information extracted from positron-emission tomography (PET) images. Then, we included to our model the ‘’5 Rs’’ of radiotherapy, to predict the effects of radiation on tumor growth. Finally, we presented a study of the effect of different types of fractionations on tumor response to radiotherapy
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Barbosa, Priscila Arruda. "O BERÇÁRIO COMO CONTEXTO DAS DCNEI Nº 5/2009 E A PRÁTICA PEDAGÓGICA COM BEBÊS: UM ESTUDO EM UMA EMEI DE SANTA MARIA/RS." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/7100.

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This dissertation aimed to investigate the relation between the pedagogical practices of the teacher of a baby nursery in a Public School of Early Childhood Education in Santa Maria/RS, and the propositions of the National Curriculum Guidelines for Early Childhood Education (approved by CNE / CEB No. 20/09 and Resolution CNE / CEB No. 05/09) for the teaching of children that are younger than six years old. In this process we tried to (a) understand the implications and possibilities of implementation of these Guidelines in the school and the teacher‟s practice, (b) understand the movements that policies have to be effective in practice, (c) discuss the concept of education of babies expressed in legal document by the teacher. The methodology chosen to conduct the research was qualitative, having its basis in the approach of the policy cycle because we understand that for a policy to be implemented or not, it is necessary to consider all of its interfaces, since its production in the macro contexts until their interpretations and changes in micro contexts. The subjects of the study were the teacher of Baby Nursery II and the director of the School of Early Childhood Education, as a source of information, we used the field diary, participant observation and structured interview. For data analysis, we opted for the content analysis, in which by the different methodological tools, the information and narratives of education professionals were characterized. As a result, it is noteworthy that although there is still misinformation about the current policies of Early Childhood Education, the conception of the child / baby is related to the legal propositions, however the pedagogical practice is justified almost exclusively by the knowledge of caring and educating, considering the actions of caring by feeding and having hygiene practices, and educating by school practices, which do not consider the baby as the protagonist of the action of being in the world.
A dissertação ora apresentada teve como objetivo geral investigar a relação entre as práticas pedagógicas da professora de berçário de uma Escola Municipal de Educação Infantil de Santa Maria/RS e as proposições das Diretrizes Curriculares Nacionais para a Educação Infantil (aprovadas pelo CNE/CEB n°20/09 e Resolução CNE/CEB nº 05/09) para o exercício docente com a criança menor de seis anos. Neste processo buscou-se (a) conhecer as implicações e possibilidades de implementação dessas Diretrizes na escola e na prática da professora dos bebês; (b) entender os movimentos que as políticas fazem para se efetivar na prática; (c) problematizar a concepção de educação dos bebês expressa no documento legal e pela professora. A opção metodológica escolhida para realizar a pesquisa foi a qualitativa, tendo sua fundamentação na abordagem do ciclo de políticas por entender que para uma política ser ou não implementada é preciso considerar todas as suas interfaces, desde a sua produção no contexto macro até suas interpretações e modificações nos contextos micros. Participaram como sujeitos do estudo a professora do berçário II e a diretora da Escola Infantil, e como fonte de informações utilizou-se o diário de campo, a observação participante e a entrevista estruturada. Para análise dos dados, optou-se pela análise de conteúdo, em que pelos diferentes recursos metodológicos foram categorizadas as informações e narrativas dos profissionais da educação. Como resultados, destacam-se que embora haja ainda uma desinformação sobre as políticas atuais de Educação Infantil, a concepção de criança/bebê é correlata às proposições legais, porém a prática pedagógica fundamente-se quase que exclusivamente pelo entendimento restrito de educar e cuidar; entendendo o cuidar pelas ações de higiene e alimentação, e o educar por práticas escolarizantes que desconsideram o bebê como protagonista da ação de ser e estar no mundo.
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Ekholm, Emy. "Bottensubstrat och dess inverkan på reducering av BOD5, COD och TKN i lakvatten genom konstruerade rotzonsanläggningar : En pilotstudie vid Univates, Lajeado – RS Brasilien." Thesis, Halmstad University, Ecology and Environmental Science, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-5179.

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Treatment wetlands been showed efficient for reducing pollutant in waste water. In Lajeado – RS, Brazil the landfill has poor leachate water treatment. It is necessary to supplement the treatment plant because they need to reduce BOD, COD and nitrate of the water going to recipient. A subsurface flow wetland (SSF) can be a good choice.  In order to be able to design an efficient SSF it is important to understand how the grain sizes of a substrate affect the reducing of pollutants in waste water. This study focus on two substrate, sand with grain size of 0 - 3 mm and gravel with the grain size of 10 - 20 mm. To see the grain size reduces BOD, COD and nitrate best, the experiment used eight pilot scales SSF for leachate water treatment, four filled with sand and four filled with gravel. Two different flows, four with batch and four used continuous flow; two of each was planted with Thypa angustifolia L. Samples were taken from each wetland every week during a four week period. The results showed that the wetlands with the fine- grained substrate; sand gave the better reduction of BOD, COD and TKN (total kjeldahl kväve). It also showed great reduction in color. Important to notice in this study is the lack of time; more samples are required to be able to establish a pattern.

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Nunes, Livia Fernanda Ribeiro. "Os 5 professores comunistas : Demetrio Ribeiro, Edgar A. Graeff, Edvaldo P. Paiva, Enilda Ribeiro, Nelson Souza." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/158420.

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Esta dissertação consiste no estudo de um grupo de 5 professores comunistas gaúchos, composto por Demetrio Ribeiro Neto, Edgar Albuquerque Graeff, Edvaldo Ruy Pereira Paiva, Enilda Ribeiro e Nelson Souza, membros do Partido Comunista Brasileiro (PCB), docentes expurgados da Universidade Federal do Rio Grande do Sul (UFRGS) pela ditadura civil-militar, em 1964, e reunidos, principalmente, pelo desejo de mudança. Atraídos por semelhanças intelectuais, profissionais e de conduta, e por dessemelhanças que, no outro, encontram seu complemento, estes profissionais uniram-se em prol de um desejo de emancipação, a eles comum, tornando o caráter de grupo indispensável ao alcance dos seus objetivos. Como intelectuais progressistas ligados organicamente à classe proletária, os 5 se autoatribuíram o compromisso de atuar ao lado do povo, mesmo no âmbito da profissão, contribuindo para a desalienação e para a construção de um projeto ideológico de cidade e sociedade. Por meio de um longo processo de estímulo ao pensamento, a qual se caracterizou por revolucionário, uma vez que pretendia mudanças irreversíveis e qualitativas, incitaram aos colegas de profissão e alunos a conhecerem a realidade social do país e, nela, intervirem de forma crítica. Orientados pelas resoluções políticas do Partido Comunista Brasileiro (PCB) e regulamentados por seus Estatutos, os 5 professores comunistas da Faculdade de Arquitetura da Universidade Federal do Rio Grande do Sul tiveram nas questões políticas propostas pelo Partido, como o anti-imperialismo, o latifúndio e a cultura nacional, tema da reflexão teórica sobre os fenômenos arquitetônicos. Por meio da docência, da militância em entidades de classe, da escrita, e como técnicos da arquitetura e do urbanismo fizeram cumprir a função social a eles conferida pelo PCB.
This dissertation consists of the study of a group of 5 Gaucho communist teachers, composed of Demetrio Ribeiro Neto, Edgar Albuquerque Graeff, Edvaldo Ruy Pereira Paiva, Enilda Ribeiro and Nelson Souza, members of the Brazilian Communist Party (PCB), expurgated teachers of the Federal University of Rio Grande do Sul (UFRGS) by the civil- military dictatorship, in 1964, and reunited, mainly, by the desire of change. Attracted by intellectual, professional and behavioral similarities, and by dissimilarities that, in the other, they find their complement, these professionals have united in favor of a desire for emancipation, common to them, making group character indispensable to reach their objectives. As progressive intellectuals organically linked to the proletarian class, the 5 self-commit the commitment to act alongside the people, even not within the scope of the profession, contributing to the desalienation and construction of an ideological project of City and Society. Through a long process of stimulus to thought, a characteristic that characterized by a revolutionary, since simulating irreversible and qualitative changes, encouraged classmates and students to get to know the social reality of the country and to intervene critically in it. Guided by political resolutions of the Brazilian Communist Party (PCB) and regulated by its statutes, the five communist professors of the Architecture College of the Federal University of Rio Grande do Sul are concerned with political issues by the Party, such as anti-imperialism, latifundia and the National Culture, theme of the theoretical reflection on the architectural phenomena. Through teaching, militancy in class entities, writing and as technicians of architecture and urbanism did fulfill the social function conferred on them by the PCB.
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Fénelon, Karine. "Les mécanismes synaptiques et intrinsèques qui sous-tendent l’activité des cellules réticulospinales (RS) en réponse à une stimulation sensorielle de type cutané chez la lamproie." Thèse, 2008. http://hdl.handle.net/1866/2836.

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Chez diverses espèces animales, les informations sensorielles peuvent déclencher la locomotion. Ceci nécessite l’intégration des informations sensorielles par le système nerveux central. Chez la lamproie, les réseaux locomoteurs spinaux sont activés et contrôlés par les cellules réticulospinales (RS), système descendant le plus important. Ces cellules reçoivent des informations variées provenant notamment de la périphérie. Une fois activées par une brève stimulation cutanée d’intensité suffisante, les cellules RS produisent des dépolarisations soutenues de durées variées impliquant des propriétés intrinsèques calcium-dépendantes et associées à l’induction de la nage de fuite. Au cours de ce doctorat, nous avons voulu savoir si les afférences synaptiques ont une influence sur la durée des dépolarisations soutenues et si l’ensemble des cellules RS partagent des propriétés d’intégration similaires, impliquant possiblement les réserves de calcium internes. Dans un premier temps, nous montrons pour la première fois qu’en plus de dépendre des propriétés intrinsèques des cellules réticulospinales, les dépolarisations soutenues dépendent des afférences excitatrices glutamatergiques, incluant les afférences spinales, pour perdurer pendant de longues périodes de temps. Les afférences cutanées ne participent pas au maintien des dépolarisations soutenues et les afférences inhibitrices glycinergique et GABAergiques ne sont pas suffisantes pour les arrêter. Dans un deuxième temps, nous montrons que suite à une stimulation cutanée, l’ensemble des cellules RS localisées dans les quatre noyaux réticulés possèdent un patron d’activation similaire et elles peuvent toutes produire des dépolarisations soutenues dont le maintien ne dépend pas des réserves de calcium internes. Enfin, les résultats obtenus durant ce doctorat ont permis de mieux comprendre les mécanismes cellulaires par lesquels l’ensemble des cellules RS intègrent une brève information sensorielle et la transforment en une réponse soutenue associée à une commande motrice.
In various animal species, sensory information can initiate locomotion. This relies on the integration of sensory inputs by the central nervous system. In lampreys, the spinal locomotor networks are activated and controlled by the reticulospinal cells (RS) which constitute the main descending system. In turn, RS cells receive information coming from various synaptic inputs such as the sensory afferents. Once activated by a brief cutaneous stimulation of sufficient strength, RS cells display sustained depolarizations of various durations that rely on calcium-dependant intrinsic properties and lead to the onset of escape swimming. During the course of this Ph.D, we aimed at determining whether synaptic inputs can modulate the duration of the sustained depolarizations and if the different populations of RS cells share the same integrative properties, possibly involving the internal calcium stores. First, our results show for the first time that excitatory glutamatergic inputs, including ascending spinal feedback, contribute to prolong the sustained depolarizations for long periods of time. Cutaneous inputs do not contribute to maintain the sustained depolarizations and inhibitory glycinergic and GABAergic inputs are not sufficient to stop them. Second, we show that in response to cutaneous stimulation, the RS located in the four reticular nuclei display a similar activation pattern and can all produce sustained depolarizations which do not depend on internal calcium release to be maintained. Finally, the results obtained during this Ph.D allowed us to better understand the cellular mechanisms by which the RS cells integrate and transform a brief sensory information into a sustained response associated with a motor command.

Books on the topic "5 Rs de radiobiologie":

1

Components, RS, ed. The RS catalogue: Book 5 - mechanical - November 1997. London: RS Components, 1997.

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David, Lewis, Meadows Daniel, and Gwent College of Higher Education. Department of Documentary Photography., eds. Education: The 5 Rs : reading, riting, rithmetic right, rong. Newport: Gwent College of Higher Education, 1988.

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Glew, Frank. The 5-rs process: A curriculum model for the teaching of environmental values education. Kitchener, Ont: Waterloo County Board of Education, 1988.

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Aziz, Abdul Halim Abdul. A study of radio activities at 5 GHZ in RS CVN and UV Ceti type stars. Manchester: University of Manchester, 1996.

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Division, Oregon State Highway, and Washington County (Or.). Dept. of Land Use and Transportation., eds. Interstate 5 to Highway 99W, Tualatin-Sherwood/Edy Road, Washington County, Oregon RS-A670(-): Final environmental impact statement. Salem, Or: Oregon State Highway Division, 1990.

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Burgess, Carter &. Categorical exclusion for RS 382-1(5)4 Perma Canyon-north, secondary highway 382, Sanders County, Montana, control no. 2026. S.l.]: Carter & Burgess, Inc., 1996.

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Simposium, Sehari"Meningkatkan Peranan Rumah Sakit Ditengah Masyarakat Yang Sedang Membangun" (1988 Jakarta Indonesia). Kumpulan makalah Simposium Sehari "Meningkatkan Peranan Rumah Sakit Ditengah Masyarakat Yang Sedang Membangun" RS Husada, 5 Nopember 1988 HUT ke-64, Jakarta. [Jakarta: s.n., 1988.

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Respublikanskai︠a︡ nauchno-prakticheskai︠a︡ konferent︠s︡iĭ molodykh uchenykh i spet︠s︡ialistov "Molodezhʹ i nauka RS (I︠A︡)" (1996 I︠A︡kutsk, Russia). Tezisy dokladov respublikanskoĭ nauchno-prakticheskoĭ konferent︠s︡ii molodykh uchenykh i spet︠s︡ialistov "Molodezhʹ i nauka RS (I︠A︡)": G. I︠A︡kutsk, 5-6 dekabri︠a︡ 1996 g. I︠A︡kutsk: [s.n.], 1996.

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American Association of Jurists. Conferência Continental. Anais: IX Conferência Continental : bases para uma nova ordem internacional, Porto Alegre, RS, Brasil, 5 a 9 de junho/junio 1991, Centro de Convenções São José, Universidade Federal do R.G. do Sul. [Brasilia?]: Editora Consulex, 1991.

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Institut), Gemeinsame Wissenschaftliche Tagung der Schweizerischen Gesellschaft für Strahlenbiologie und Medizinische Physik und der Schweizerischen Gesellschaft für Biomedizinische Technik (1993 Paul Scherrer. Gemeinsame Wissenschaftliche Tagung der Schweizerischen Gesellschaft für Strahlenbiologie und Medizinische Physik (SGSMP) und der Schweizerischen Gesellschaft für Biomedizinische Technik (SGBT): Tagungsberichte = Journée commune scientifique de la Sociéte suisse de la radiobiologie et de physique médicale (SSRPM) et de la Sociéte suisse de génie médicale (SSGM) : compte-rendu : proceedings, PSI, Paul Scherrer Institut, Villigen, 4./5. November 1993. Kerzers: Verlag M. Huber, 1993.

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Book chapters on the topic "5 Rs de radiobiologie":

1

Dawoud, Dawoud Shenouda, and Peter Dawoud. "RS-232 Variants RS-422/RS-423, RS-449, RS-485, and EIA-530." In Serial Communication Protocols and Standards, 169–90. New York: River Publishers, 2022. http://dx.doi.org/10.1201/9781003339496-5.

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Cath, Yuri. "Knowing what it is like and the three “Rs”." In Imagination and Experience, 50–67. New York: Routledge, 2024. http://dx.doi.org/10.4324/9781003366898-5.

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Wong, Erik H. F., Douglas W. Bonhaus, and Richard M. Eglen. "The Identification of Heterogeneity of 5-HT3 Receptors with [3H]RS-42358-197." In Neurochemistry in Clinical Application, 97–108. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1857-0_12.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of ion-pair complex consisting of (RS)-indan-1-aminium-(dibenzo)[18]crown-6 and nickel(III) 2-thioxo-1,3-dithole-4,5-dithiolate anion." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 5, 948–50. Berlin, Heidelberg: Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-65098-1_360.

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Malik, Sajid. "Robotic Surgery: Operating Room Setup and Docking." In Mastering Endo-Laparoscopic and Thoracoscopic Surgery, 555–63. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-3755-2_75.

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AbstractRobotic surgery (RS) continues to impart its role in minimally invasive surgery (MIS) since its first emergence. It has rapidly been adopted by different specialties including general surgery, urology, gynecology, and orthopedic surgery, and now is becoming a mainstay of MIS technique around the globe [1–3]. During the last 30 years, many different robotic systems came into surgical practice but the da Vinci® is currently the most commonly utilized and is available in four different models (standard, streamlined, streamlined High definition, S-integrated). Despite its enhanced view of 3D system and angulations of instruments, its practical application for training surgical residents is less emphasized and addressed [4, 5]. This chapter will guide in the basic principles of setting operating room and equipments for da Vinici®. It is further emphasized that hands-on training on simulators and in operating rooms under a trained mentor is highly suggestive of learning robotic skills.
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De Smith Roberts, Rachel M. "Embodied Love(rs):." In Renaissance Papers 2021, 25–36. Boydell & Brewer Ltd, 2022. http://dx.doi.org/10.2307/j.ctv2mwg28w.5.

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Frenzel, Louis E. "RS-232." In Handbook of Serial Communications Interfaces, 109–12. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-800629-0.00025-5.

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Klamt, Andreas. "Statistical thermodynamics of interacting surfaces." In COSMO-RS, 59–81. Elsevier, 2005. http://dx.doi.org/10.1016/b978-044451994-8/50005-5.

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Kumar, Nilesh, Rajiv S. Mishra, and John A. Baumann. "Mitigation of RS During FSW." In Residual Stresses in Friction Stir Welding, 36–40. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-800150-9.00014-5.

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Manabe, Yusuke, and Kenji Sugawara. "Sitting Posture Recognition and Location Estimation for Human-Aware Environment." In Advances in Abstract Intelligence and Soft Computing, 317–31. IGI Global, 2013. http://dx.doi.org/10.4018/978-1-4666-2651-5.ch021.

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Realization of human-computer symbiosis is an important idea in the context of ubiquitous computing. Symbiotic Computing is a concept that bridges the gap between situations in Real Space (RS) and data in Digital Space (DS). The main purpose is to develop an intelligent software application as well as establish the next generation information platform to develop the symbiotic system. In this paper, the authors argue that it is necessary to build ’Mutual Cognition’ between human and system. Mutual cognition consists of two functions: ’RS Cognition’ and ’DS Cognition’. This paper examines RS Cognition, which consists of many software functions for perceiving various situations like events or humans’ activities in RS. The authors develop two perceptual functions, sitting posture recognition and human’s location estimation for a person, as RS perception tasks. In the resulting experiments, developed functions are quite competent to recognize a human’s activities.

Conference papers on the topic "5 Rs de radiobiologie":

1

Rocha, Kenny de Souza, Josefina Barrera Kalhil, Jorge de Menezes Rodrigues, and Maria Clara da Silva Forsberg. "Oficina Suzana: Aprendizagem Baseada em Problemas para os 5 Rs da Sustentabilidade." In Anais do Seminário de Boas Práticas de Ensino e Aprendizagem (SBPEA) da EEL-USP. Recife, Brasil: Even3, 2024. http://dx.doi.org/10.29327/1365929.3-13.

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Paim, Hiago Gatto Loureiro, and Mônica Lourdes Palomino de Los Santos. "PERFIL DOS PROFISSIONAIS DE NUTRIÇÃO ATUANTES EM CLÍNICAS NA CIDADE DE BAGÉ/RS." In Anais do Congresso Brasileiro de Nutrição Comportamental. Recife, Brasil: Even3, 2023. http://dx.doi.org/10.29327/1279906.9-5.

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"Residual Stress Measurement of Additively Repaired Ti-6Al-4V Using Fibre Optic Sensing." In Structural Health Monitoring. Materials Research Forum LLC, 2021. http://dx.doi.org/10.21741/9781644901311-5.

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Abstract. Laser metal deposition (LMD) is a laser-based additive manufacturing (AM) technology that offers significant advantages in the production and repair of bespoke and valuable parts targeting applications in the aerospace, tooling and medical industries. A significant problem with AM is the development of high residual stresses, deformation and cracking. Advanced sensing technologies can be a useful tool for characterising residual stress (RS) and the structural response of AM aerospace components under fatigue loading conditions. This paper reports on a feasibility study assessing the performance of fibre optic (FO) distributed strain measurement technology to measure surface RS in comparison to traditional electrical resistance strain gauges and the contour method. The results from this study will be used to justify further experimental work.
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Chino, T., K. Matsuda, H. Adachi, and J. Shibata. "A Novel Optoelectronic RS Flip-Flop Based on Optically Coupled Inverters." In 1992 International Conference on Solid State Devices and Materials. The Japan Society of Applied Physics, 1992. http://dx.doi.org/10.7567/ssdm.1992.b-5-4.

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Diaconu, Felix, Luminita Scripcariu, and Petre-Daniel Matasaru. "Hardware design of an RS (7, 5) data coding circuit used by digital communication systems." In 2017 International Symposium on Signals, Circuits and Systems (ISSCS). IEEE, 2017. http://dx.doi.org/10.1109/isscs.2017.8034890.

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Zanon, Riccardo, Dennis Rademacher, Günter Seidl, and Daniel Pak. "Integral VFT-RS composite bridges - Efficient standard highway overpasses." In IABSE Symposium, Prague 2022: Challenges for Existing and Oncoming Structures. Zurich, Switzerland: International Association for Bridge and Structural Engineering (IABSE), 2022. http://dx.doi.org/10.2749/prague.2022.1013.

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<p>Starting from Germany, the VFT® bridge girder technology (prefabricated composite beam) has spread in several European countries in the last decades as further development of the standard steel-concrete composite solution. Its configuration fits perfectly to integral frame bridges built over existing infrastructure with the scope to minimize the traffic disturbance. In this paper a further development with the focus on cost efficiency in span ranges of 40-55 m is proposed: the VFT-RS technology. The change consists in using standard rolled sections by adapting them into the integral frame bridge configuration, further enhancing the structural efficiency with the benefits of high- steel strength. The constructive details to achieve the polygonal form have been studied to allow easy fabrication and a maximal clearance height over highway traffic lanes. The VFT-RS solution is conceived as the economic option of standard highway overpasses, with the aim of an overall construction cost reduction of 5%.</p>
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Bruno, G., E. Riccardi, A. Rossaro, F. Cugini, and N. Sambo. "Evolutions of a pan-European Network over TrueWave-RS Fiber Enabled by Flexible Grid and Coherent Detection." In National Fiber Optic Engineers Conference. Washington, D.C.: OSA, 2012. http://dx.doi.org/10.1364/nfoec.2012.jw2a.5.

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Deizi Vanessa Peron, Guilherme de Souza, Michèle Oberson de Souza, Liliana Amaral Feris, and Nilson Romeu Marcilio. "Síntese de zeólita do tipo ZSM-5 a partir de cinzas volantes de carvão mineral de Candiota - RS." In V Congresso Brasileiro de Carvão Mineral. Porto Alegre, Brazil: Rede de Pesquisa, Desenvolvimento e Inovação do Carvão Mineral – Rede Carvão, 2017. http://dx.doi.org/10.20906/cps/cbcm2017-0094.

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Yildirim, Unal, and Murat Uysal. "Changes in the Coastline of the Burdur Lake Between 1975 and 2010." In International Symposium on Environmental Protection and Planning: Geographic Information Systems (GIS) and Remote Sensing (RS) Applications. Cevre Koruma ve Arastirma Vakfi, 2012. http://dx.doi.org/10.5053/isepp.2011.1-5.

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He, Chansheng, and Thomas E. Croley. "Hydrologicalal Resource Sheds and Water Quality Management in North America's Great Lakes Watersheds." In International Symposium on Environmental Protection and Planning: Geographic Information Systems (GIS) and Remote Sensing (RS) Applications. Cevre Koruma ve Arastirma Vakfi, 2012. http://dx.doi.org/10.5053/isepp.2011.2-5.

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