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Published: 1 June 2024

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1

Andreasyan, N. K., and �. E. Khachikyan. "Spectrophotometric investigation of NGC 4922." Astrophysics 24, no. 1 (1986): 9–14. http://dx.doi.org/10.1007/bf01005565.

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ㅤ. "Van Zeeland / De Louw-Thijssen (TvAR 1998/4922)." Tijdschrift voor Agrarisch Recht 58, no. 7 (July 1, 1998): ㅤ. http://dx.doi.org/10.5117/tvar1998.7-8.004.

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Sheen, Yun-Kyeong, Hyunjin Jeong, Sukyoung K. Yi, Ignacio Ferreras, Jennifer M. Lotz, Knut A. G. Olsen, Mark Dickinson, et al. "TIDAL DWARF GALAXIES AROUND A POST-MERGER GALAXY, NGC 4922." Astronomical Journal 138, no. 6 (November 5, 2009): 1911–16. http://dx.doi.org/10.1088/0004-6256/138/6/1911.

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4

Johnson-Holiday, Crystal, Shailesh Singh, Erica Johnson, Udai Singh, and James W. Lillard. "CCR9-CCL25 interaction mediates breast cancer cell survival via Akt activation (49.22)." Journal of Immunology 178, no. 1_Supplement (April 1, 2007): S87. http://dx.doi.org/10.4049/jimmunol.178.supp.49.22.

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Abstract Breast cancer (BrCa) is one of the most frequently diagnosed cancers and the second leading cause of cancer-related deaths in the U.S. Most cancer-related deaths are due to metastasis. In addition, BrCa cells readily become resistant to a wide variety of chemotherapeutic agents, which is a major obstacle in the treatment of BrCa. Tumor cell migration and metastasis share similarities with leukocyte trafficking, which is regulated, in part, by chemokines and their receptors. We have previously shown that CCR9 is functionally expressed by BrCa cells and its expression is enhanced by the presence of its ligand, CCL25. This study characterizes the role of CCL25-CCR9 cell-signaling cascades involved in BrCa cell resistance to cisplatin. This drug is often ineffective due to cancer cell resistance and the development of anti-apoptotic mechanisms. In this regard, CCR9-CCL25 interaction plays a role in immature T-cell survival through PI3K and G ai protein-dependent activation of Akt/protein kinase B. Activated Akt phosphorylates multiple downstream targets that are involved in cell survival signaling, which include glycogen synthase kinase (GSK-3), forkhead transcriptional factor (FKHR), and caspase-9. We examined the effect of CCR9-CCL25 interactions on BrCa cell lines MDA-MB-231 and MDA-435, with or without cisplatin treatment. CCR9-CCL25 interactions decreased cisplatin-induced apoptosis. These interactions also modulated the activation of cell signaling cascades involved in cell survival. These studies provide important new information regarding the cellular and molecular mechanisms that mediate BrCa cell survival.
5

Van den Ende, Wim. "Different evolutionary pathways to generate plant fructan exohydrolases." Journal of Experimental Botany 73, no. 14 (August 11, 2022): 4620–23. http://dx.doi.org/10.1093/jxb/erac305.

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This article comments on: Oku S, Ueno K, Sawazaki Y, Maeda T, Jitsuyama Y, Suzuki T, Onodera S, Fujino K, Shimura H. 2022. Functional characterization and vacuolar localization of fructan exohydrolase derived from onion (Allium cepa). Journal of Experimental Botany 73,4908–4922.
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Alonso-Herrero, A., M. J. Ward, A. Aragon-Salamanca, and J. Zamorano. "Multifrequency observations of the interacting galaxy NGC 4922 (UCM 1259 + 2934)." Monthly Notices of the Royal Astronomical Society 302, no. 3 (January 21, 1999): 561–70. http://dx.doi.org/10.1046/j.1365-8711.1999.02171.x.

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Zhang, Jin, Hai-Ming Zhang, Su Yao, Sheng-Chu Guo, Rui-Jing Lu, and En-Wei Liang. "Jet Radiation Properties of 4C +49.22: from the Core to Large-scale Knots." Astrophysical Journal 865, no. 2 (September 26, 2018): 100. http://dx.doi.org/10.3847/1538-4357/aadd0b.

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8

McLoughlin, John Grant. "Solutions to Calendar." Mathematics Teacher 91, no. 4 (April 1998): 311–15. http://dx.doi.org/10.5951/mt.91.4.0311.

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Problems 1-9, 13-18, and 25 were contributed by Todd Swanson, Department of Mathematics, Hope College, Holland, MI 49422-9000. Problems 10, 11, and 19-23 were submitted by Calvin T. Long, Department of Mathematics, Northern Arizona University, P. 0. Box 5717, Flagstaff, AZ 86011-5717. Problems 12 and 27-30 were prepared by Marian Small, Faculty of Education, University of New Brunswick, Fredericton, NB E3B 6E3. Problems 24 and 26 were offered by HarrisS. Shultz, California State University, Fullerton, P. 0. Box 6850, Fullerton, CA 92834-6850.
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Wadle, Lisa-Marie, Ulrich W. Ebner-Priemer, Jerome C. Foo, Yoshiharu Yamamoto, Fabian Streit, Stephanie H. Witt, Josef Frank, et al. "Speech Features as Predictors of Momentary Depression Severity in Patients With Depressive Disorder Undergoing Sleep Deprivation Therapy: Ambulatory Assessment Pilot Study." JMIR Mental Health 11 (January 18, 2024): e49222. http://dx.doi.org/10.2196/49222.

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Background The use of mobile devices to continuously monitor objectively extracted parameters of depressive symptomatology is seen as an important step in the understanding and prevention of upcoming depressive episodes. Speech features such as pitch variability, speech pauses, and speech rate are promising indicators, but empirical evidence is limited, given the variability of study designs. Objective Previous research studies have found different speech patterns when comparing single speech recordings between patients and healthy controls, but only a few studies have used repeated assessments to compare depressive and nondepressive episodes within the same patient. To our knowledge, no study has used a series of measurements within patients with depression (eg, intensive longitudinal data) to model the dynamic ebb and flow of subjectively reported depression and concomitant speech samples. However, such data are indispensable for detecting and ultimately preventing upcoming episodes. Methods In this study, we captured voice samples and momentary affect ratings over the course of 3 weeks in a sample of patients (N=30) with an acute depressive episode receiving stationary care. Patients underwent sleep deprivation therapy, a chronotherapeutic intervention that can rapidly improve depression symptomatology. We hypothesized that within-person variability in depressive and affective momentary states would be reflected in the following 3 speech features: pitch variability, speech pauses, and speech rate. We parametrized them using the extended Geneva Minimalistic Acoustic Parameter Set (eGeMAPS) from open-source Speech and Music Interpretation by Large-Space Extraction (openSMILE; audEERING GmbH) and extracted them from a transcript. We analyzed the speech features along with self-reported momentary affect ratings, using multilevel linear regression analysis. We analyzed an average of 32 (SD 19.83) assessments per patient. Results Analyses revealed that pitch variability, speech pauses, and speech rate were associated with depression severity, positive affect, valence, and energetic arousal; furthermore, speech pauses and speech rate were associated with negative affect, and speech pauses were additionally associated with calmness. Specifically, pitch variability was negatively associated with improved momentary states (ie, lower pitch variability was linked to lower depression severity as well as higher positive affect, valence, and energetic arousal). Speech pauses were negatively associated with improved momentary states, whereas speech rate was positively associated with improved momentary states. Conclusions Pitch variability, speech pauses, and speech rate are promising features for the development of clinical prediction technologies to improve patient care as well as timely diagnosis and monitoring of treatment response. Our research is a step forward on the path to developing an automated depression monitoring system, facilitating individually tailored treatments and increased patient empowerment.
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Bhargava, Hansa, Carmela Salomon, Srinivasan Suresh, Anthony Chang, Rachel Kilian, Diana van Stijn, Albert Oriol, Daniel Low, Ashley Knebel, and Sharief Taraman. "Promises, Pitfalls, and Clinical Applications of Artificial Intelligence in Pediatrics." Journal of Medical Internet Research 26 (February 29, 2024): e49022. http://dx.doi.org/10.2196/49022.

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Artificial intelligence (AI) broadly describes a branch of computer science focused on developing machines capable of performing tasks typically associated with human intelligence. Those who connect AI with the world of science fiction may meet its growing rise with hesitancy or outright skepticism. However, AI is becoming increasingly pervasive in our society, from algorithms helping to sift through airline fares to substituting words in emails and SMS text messages based on user choices. Data collection is ongoing and is being leveraged by software platforms to analyze patterns and make predictions across multiple industries. Health care is gradually becoming part of this technological transformation, as advancements in computational power and storage converge with the rapid expansion of digitized medical information. Given the growing and inevitable integration of AI into health care systems, it is our viewpoint that pediatricians urgently require training and orientation to the uses, promises, and pitfalls of AI in medicine. AI is unlikely to solve the full array of complex challenges confronting pediatricians today; however, if used responsibly, it holds great potential to improve many aspects of care for providers, children, and families. Our aim in this viewpoint is to provide clinicians with a targeted introduction to the field of AI in pediatrics, including key promises, pitfalls, and clinical applications, so they can play a more active role in shaping the future impact of AI in medicine.
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Mironenko, N., O. Filatova, and O. Afanasenko. "Genetic control of Pyrenophora teres virulence to three barley accessions." Plant Protection Science 38, SI 2 - 6th Conf EFPP 2002 (December 31, 2017): 612–14. http://dx.doi.org/10.17221/10569-pps.

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Ascospore progeny of cross of Pyrenophora teres f. teres isolates was evaluated on virulence to three barley genotypes. Monogenic inheritance of virulence (26 a:17 v and 31 a:18 v) was shown to cultivar Harbin and accession c 21272 and supported by results of two fungal backcrosses. The existence of three unlinked avirulence genes to CI 4922 is suggested (37 a:7 v). The model of interaction between barley resistance genes and avirulence genes with postulated fungal genotypes is proposed.
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Kryukov, Kirill, Suren Davitavyan, Danil Stupichev, Anna Sharun, Anna Love, Mikhail Kleimenov, Stepan Kuznetsov, Arina Tkachuk, and Vladimir Kushnarev. "Abstract 4922: Unraveling sarcomatoid features in clear cell renal cell carcinoma with RNA-seq." Cancer Research 84, no. 6_Supplement (March 22, 2024): 4922. http://dx.doi.org/10.1158/1538-7445.am2024-4922.

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Abstract Introduction: Sarcomatoid сlear cell renal cell carcinoma (ccRCC) represents a challenging and aggressive subset of kidney cancers with poor prognosis and resistance to conventional treatments. Recent studies have shown the benefit of checkpoint inhibitors (CPIs) for patients with sarcomatoid components; therefore, precise and objective evaluation of sarcomatoid differentiation is essential for CPI selection. Here, we developed a predictive model to identify sarcomatoid features in ccRCC. Methods: The machine learning-based transcriptomic sccRCC model was developed on 512 samples from publicly available datasets: TCGA-KIRC and CPTAC-ccRCC. Samples were excluded with the following criteria: inconsistent with ccRCC, less than 10% sarcomatoid component, or <20% tumor neoplastic cellularity. Sarcomatoid features for each case were assessed by 3 pathologists. The meta-cohort was divided into training (n = 348) and validation (n = 164) cohorts.The model was tested on a publicly available cohort of ccRCC patients from Sato et al. (n = 100). Clinical validation was performed using an additional prospective cohort that received BostonGene’s Tumor PortraitTM test (n = 32) with RNA-seq and whole exome sequencing (WES). The JAVELIN Renal 101 cohort was used to uncover differences in progression-free survival (PFS) associated with a predicted sarcomatoid component in advanced or metastatic ccRCCs treated with a combination of CPIs and tyrosine kinase inhibitors (TKIs). Results: H&E analysis of the TCGA, CPTAC, and BostonGene cohorts identified zones with sarcomatoid features in 129 out of 556 (23.2%) samples. The sarcomatoid predictive model demonstrated robust performance, with weighted F1-scores of 0.85 when applied to the test cohort (Sato et al.) and 0.70 for the prospective clinical cohort. The model accurately classified 9 out of 10 total sarcomatoid samples in the prospective clinical cohort, highlighting its potential for real-world clinical applications. When applied to TCGA validation samples, sarcomatoid patients identified by the transcriptomic model exhibited median overall survival (mOS) of 55 months, whereas sarcomatoid patients based on H&E assessment had a mOS of 67 months, indicative of the model’s superior performance when detecting sarcomatoid features for OS prediction. Moreover, the sarcomatoid ccRCCs predicted by transcriptomic model that were treated with a combination of CPIs and TKIs had statistically (p=0.0001) improved PFS compared to the TKI-treated group. Conclusion: The developed transcriptomic model effectively differentiated sarcomatoid from non-sarcomatoid ccRCC samples with robust performance metrics. With additional investigation, the predictive value of the sarcomatoid ccRCC transcriptomic model can be leveraged to guide CPI and TKI selection. Citation Format: Kirill Kryukov, Suren Davitavyan, Danil Stupichev, Anna Sharun, Anna Love, Mikhail Kleimenov, Stepan Kuznetsov, Arina Tkachuk, Vladimir Kushnarev. Unraveling sarcomatoid features in clear cell renal cell carcinoma with RNA-seq [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 4922.
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Simpkin, Sarah. "Books Reviewed by: Carina Xue Luo, Rhys Stevens and Siobhan Hanratty." Bulletin - Association of Canadian Map Libraries and Archives (ACMLA), no. 158 (March 22, 2018): 13–18. http://dx.doi.org/10.15353/acmla.n158.219.

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Ballas, Dimitris, Graham Clarke, Rachel S. Franklin, and Andy Newing. GIS and the Social Sciences: Theory and Applications. First edition. New York: Routledge, 2018. 280p. $59.95 USD. ISBN 978-1-138-78512-0. Bodenstein, Wulf. Exploring Africa with Ancient Maps. Tervuren, Belgium: Royal Museum for Central Africa, 2017. 296p. 19,50 €. ISBN 978-9-4922-4479-6.Gorr, Wilpen L, and Kristen S. Kurland. GIS Tutorial 1 for ArcGIS Pro: A Platform Workbook. Redlands, CA: Esri Press, 2017. 480p. 99.99 USD. ISBN Print: 9781589484665 ISBN Digital: 9781589484931.
14

Roland, Jens. "Decline in Winter Moth Populations in North America: Direct Versus Indirect Effect of Introduced Parasites." Journal of Animal Ecology 57, no. 2 (June 1988): 523. http://dx.doi.org/10.2307/4922.

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Li, Lusi, Liuliu Fu, and Wenlu Zhang. "Impact of Text Diversity on Review Helpfulness: A Topic Modeling Approach." Interdisciplinary Journal of Information, Knowledge, and Management 17 (2022): 087–100. http://dx.doi.org/10.28945/4922.

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Aim/Purpose: In this study, we aim to investigate the impact of an important characteristic of textual reviews – the diversity of the review content on review helpfulness. Background: Consumer-generated reviews are an essential format of online Word-of-Month that help customers reduce uncertainty and information asymmetry. However, not all reviews are equally helpful as reflected by the varying number of helpfulness votes received by reviews. From consumers’ perspective, what kind of content is more effective and useful for making purchase decisions is unclear. Methodology: We use a data set consisting of consumer reviews for laptop products on Amazon from 2014 to 2018. A topic modeling technique is implemented to unveil the hidden topics embedded in the reviews. Based on the extracted topics, we compute the text diversity score of each review. The diversity score measures how diverse the content in a review is compared to other reviews. Contribution: In the literature, studies have examined various factors that can influence review helpfulness. However, studies that emphasized the information value of textual reviews are limited. Our study contributes to the extant literature of online word-of-mouth by establishing the connection between the diversity of the review content and consumer perceived helpfulness. Findings: Empirical results show that text diversity plays an important role in consumers’ evaluation of whether the review is helpful. Reviews that contain more diverse content tend to be more helpful to consumers. Moreover, we find a negative interaction effect between text diversity and the text depth. This result suggests that text depth and text diversity have a substitution effect. When a review contains more in-depth content, the impact of text diversity is weakened. Recommendations for Practitioners: For consumers to quickly find the informative reviews, platforms should incorporate measures such as text diversity in the ranking algorithms to rank consumer reviews. Future Research: Future study can extend the current research by examine the impact of text diversity for experienced goods and compare the results with search goods.
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Situmorang, Adi S. "MICROSOFT TEAMS FOR EDUCATION SEBAGAI MEDIA PEMBELAJARAN INTERAKTIF MENINGKATKAN MINAT BELAJAR." Sepren 2, no. 1 (September 28, 2020): 30. http://dx.doi.org/10.36655/sepren.v2i1.351.

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Tujuan penelitian ini adalah untuk mengetahui persentasi pencapaian minat belajar mahasiswa prodi pendidikan matematika FKIP UHN yang diajarkan dengan pembelajaran Microsoft Teams for Education sebagai media pembelajaran interaktif untuk jarak jauh (online). Hasil penelitian menunjukkan bahwa: Kesimpulkan dari penelitian ini adalah: 1) Secara keseluruhan bahwa minat belajar mahasiswa yang mengikuti pembelajaran dengan menggunanakan Microsoft Teams for Education berada dalam kategori “Sangat Baik” karena 94 orang dari 110 orang atau sekita 85,46% mahasiswa telah mencapai nilai tinggi (³75). 2) Presentase peningkatan pencapaian minat belajar mahasiswa sebelum dan sesudah pembelajaran model pencapaian konsep untuk masing masing-indikator adalah 49,22%, 49,48%, 49,48%, dan 52,34 (semua kategori sangat baik). Hal ini menunjukkan bahwa pemmbelajaran menggunakan Microsoft Teams for Education sangat baik digunakan untuk meningkatkan minat belajar peserta didik.
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Wang, Yu, and Jiafa Zhu. "Pricing Analysis for Railway Multi-Ride Tickets: An Optimization Approach for Uncertain Demand within an Agreed Time Limit." Mathematics 11, no. 23 (November 29, 2023): 4818. http://dx.doi.org/10.3390/math11234818.

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A multi-ride ticket with a certain period of validity and maximum number of uses has been introduced into railway transport. The key to pricing the railway multi-ride ticket is determining the uncertain demand within an agreed time limit. Unfortunately, limited studies have focused on this pricing issue. Therefore, we focused on railway multi-ride ticket pricing optimization in two different scenarios: a single train with multiple stops and multiple trains with multiple stops. First, the expected coefficient and incentive coefficient were introduced to describe the decision-making process for multi-ride tickets and simulate the change in passengers’ travel behavior after purchasing multi-ride tickets. Then, passenger demand functions based on a normal distribution were developed to establish the pricing models with maximized revenue. Finally, we adopted improved particle swarm optimization (PSO) to solve the models. Two numerical cases were used to verify the models separately for two application scenarios. The results revealed that the multi-ride ticket pricing problem is not a simple summation of pricing for one-time travel of passengers. In the situation of a single train with multiple stops, the expected coefficient is positively related to the total income, whereas the incentive coefficient has limited influence on the optimal price and total revenue. Furthermore, a multi-ride ticket should allow the passenger to take trains eight times at most in 8 days at the price of CNY 4922 (abbreviated as 4922 (8, 8)) rather than 3785 (8, 6). Railway enterprises should cautiously limit the scope of trains available for multi-ride tickets in the case of multiple trains with multiple stops.
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Dharmawan, Agus, Ida Bagus Suryaningrat, Siswoyo Soekarno, and Fiqih Faresa Firdaus. "Techno-Economic Evaluations on the Liquid Smoke Production from Coconut Shells (Case Study at CV Prima Rosandries, Jember)." Jurnal Penelitian Pertanian Terapan 20, no. 2 (October 27, 2020): 126–34. http://dx.doi.org/10.25181/jppt.v20i2.1621.

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The research aimed to evaluate techno-economic on liquid smoke production from coconutshells in small business, CV Prima Rosandries, Jember. The techno analysis was determinedby calculating work capacity and yield, which resulted in 2,04 kg/hour dan 49,22%,respectively. In cost analysis, CV Prima Rosandries required IDR186,750,000.00 as firstcost and IDR110,358,000.00 for annual-operation costs, also gained annual incomesIDR151,200,000.00 and estimated-asset value IDR15,525,000.00. In investment evaluation,parameters, such as NPV, AE, BCR, RoR, and PBP, showed that the investment was infeasible and profitable condition. To gained a break-even point, CV Prima Rosandriesobliged to sell 46,542 products and costly IDR372,336,449.00. In the sensitivity analysis,percentage changes in investment factors resulted in 16.29% for interest rate, 32.13% forfirst cost, 8.85% for annual cost, and -6.46% for annual benefit.
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Costillo Borrego, Emilio, Ana Belén Borrachero Cortés, Mª Antonia Dávila Acedo, and María Brígido Mero. "VALORACIÓN POR LOS PROFESORES EN FORMACIÓN DEL DOMINIO AFECTIVO EN LAS SALIDAS AL MEDIO NATURAL COMO ACTIVIDADES DE ENSEÑANZA-APRENDIZAJE." International Journal of Developmental and Educational Psychology. Revista INFAD de Psicología. 7, no. 1 (January 30, 2017): 213. http://dx.doi.org/10.17060/ijodaep.2014.n1.v7.793.

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Abstract.ASSESSMENT OF PROSPECTIVE TEACHERS ABOUT AFFECTIVE DOMAIN IN NATURE FIELD TRIPS AS TEACHING AND LEARNING ACTIVITIESScience field trips of students have a positive impact about learning-teaching of Biology and Geology area. Nevertheless, few teachers carry out such activities in the right way. One reason could be the lack of studies concerning to activities focusing in the cognitive and affective teacher domains, especially in the first step of teacher education. Preliminary studies of our research group have shown that future teachers have wrong pedagogical concepts about these activities, sometimes related to their own experience as students. We study the assessment of prospective teachers about affective domain in nature field trips as teaching and learning activities. We analyzed 130 prospective teachers, 81 primary prospective teachers and 49 secondary prospective teachers. We use a single reflection on the merits of the science field trips with respect to the classroom. These prospective teachers were very much in agreement with the importance of these activities in enhancing their pupils’ affective domain. The 49.22% reported that science field trips generated improvements in the affective domain. Although this percentage is higher in secondary prospective teachers than primary prospective teachers (55.10% vs. 49.68%), the differences were not significant. No significant differences were found regarding gender of prospective teachers. Currently when it dominates a negative view of science among students is an important role for these activities. Therefore it is necessary to work these science field trip in-prospective teachers as they play a key role in the teaching and learning of these subjectsKeywords: Science field trip; affective domain; Teaching and learning activities; teacher training.Resumen.Las salidas al medio natural son de gran importancia en la enseñanza-aprendizaje de la Biología y Geología. Sin embargo, todavía son pocos los profesores que integran estas actividades en su docencia y en muchos casos lo hacen de forma poco provechosa. Además, apenas hay estudios centrados en el dominio cognitivo y afectivo de los profesores en este campo, y en particular durante las primeras etapas de su formación. Existe, por tanto, una carencia de información sobre la realización de estas actividades. Estudios preliminares de nuestro grupo de investigación han mostrado que los futuros docentes presentan concepciones pedagógicas erróneas e irreflexivas sobre estas actividades, a veces relacionadas con su propia experiencia como alumnos. Estudiamos la valoración por los profesores en formación del dominio afectivo en las salidas al medio natural como actividades de enseñanza-aprendizaje. Analizamos 130 profesores en formación, 81 profesores en formación de educación primaria y 49 de secundaría. Utilizamos una reflexión individual sobre las ventajas de las salidas al medio real con respecto a las aulas. El 49,22% señalaron que las salidas al medio natural generaban mejoras en el plano afectivo. Aunque este porcentaje es más alto en los profesores de secundaria que los de primaria (55,10% vs. 49,68%), las diferencias no fueron significativas. Tampoco se detectaron diferencias significativas en cuanto al género de los profesores. Actualmente cuando domina una visión negativa de las ciencias entre el alumnado es importante el papel de estas actividades. Por tanto es necesario trabajar estas salidas al medio natural en profesores en formación pues juegan un papel fundamental en la enseñanza-aprendizaje de estas asignaturasPalabras clave: salidas al medio natural, emociones, formación del profesorado, enseñanza aprendizaje del medio natural
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Mathew, Stephen O., Jong R. Kim, Raymond M. Pertusi, Rahul K. Patel, and Porunelloor A. Mathew. "Analysis of SLAM family receptors 2B4, CS1 and NTB-A in patients with Systemic Lupus Erythematosus (SLE) (49.22)." Journal of Immunology 182, no. 1_Supplement (April 1, 2009): 49.22. http://dx.doi.org/10.4049/jimmunol.182.supp.49.22.

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Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease, characterized by the improper regulation of B lymphocytes that leads to the production of auto-antibodies. Several studies have identified a genetic susceptibility region called Sle 1 in mice and some human subjects. Recently, genomic characterization of the Sle1b locus, identified a highly polymorphic cluster of genes coding for the signaling lymphocyte activation molecule (SLAM)-related receptors (SRRs). 2B4 (CD244), CS1 (CD319, CRACC) and NTB-A are members of SRRs and are expressed on NK, T, B cells and monocytes. The aim of this study was to investigate expression of members of the SRRs in peripheral blood mononuclear cells (PBMC) from patients with SLE. We analyzed PBMC from forty-six patients with SLE and thirty-one healthy individuals. The surface expressions of 2B4, CS1, and NTB-A on T cells, B cells, NK cells, and monocytes were analyzed by flow cytometry. 2B4 expression was upregulated on T cells but down-regulated on NK cells and monocytes in patients with SLE. B cells from patients with SLE significantly overexpressed CS1 compared to B cells from healthy controls. The surface expression of NTB-A was upregulated on T cells and monocytes, but down-regulated on B cells in patients with SLE. Our results suggest that altered expression of SRRs may be related to the abnormal B cell hyperactivity in patients with SLE. (Research supported by grants from Texas Higher Education Board and UNTHSC).
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Li, Juan, and Michael Murtaugh. "Dissociation of porcine reproductive and respiratory syndrome virus neutralization from antibody production to major envelope protein peptides (49.22)." Journal of Immunology 186, no. 1_Supplement (April 1, 2011): 49.22. http://dx.doi.org/10.4049/jimmunol.186.supp.49.22.

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Abstract Porcine reproductive and respiratory syndrome (PRRS) is the most severe infectious disease facing the swine industry worldwide. The etiologic agent is PRRSV, an enveloped arterivirus. GP5 and M, the major envelope proteins, form disulfide-bonded heterodimeric complexes that are involved in PRRSV entry into porcine alveolar macrophages (PAM). Previous studies identified several neutralization epitopes in GP5 polypeptide, containing amino acid residues (AA) 29-52, and potential unknown neutralization epitopes in M protein. To test whether PRRSV-neutralizing antibodies (NA) are directed to GP5 and M ectodomain polypeptides, we constructed three recombinant single-chain proteins: the two predicted ectodomains of GP5 (GP5-5’), the two ectodomains of M (M-5’), and all four ectodomains (GP5-M). In particular, GP5-5’ contains the reported neutralization epitopes. We found that the convalescent pig sera after PRRSV infection contained various levels of antibodies to those proteins, but the Ab titers did not correlate with the NA response. Immunization of pigs with these recombinant proteins did not induce detectable NA response. Finally, protein-specific Abs that were purified from PRRSV-neutralizing serum by affinity chromatography showed no neutralizing activity, whereas the protein-specific Ab-depleted sera retained similar neutralizing activity as the original sera. The results, therefore, do not support that PRRSV-NA are directed to the ectodomain polypeptides of GP5/M.
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SHINTANI, Masanori, Hiroyuki SHUME, Hajime TAKADA, and Tadashi KOTERA. "4922 Construction of Analysis Model and Evaluation of Energy Absorption in Nonlinear Vibration System with Gaps." Proceedings of the JSME annual meeting 2006.5 (2006): 533–34. http://dx.doi.org/10.1299/jsmemecjo.2006.5.0_533.

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Ahn, Jangyong, Jedok Kim, Dongryul Park, Haerim Kim, and Seungyoung Ahn. "An Active Shielding Control Method for a Wireless Power Transfer System under Misalignment Conditions." Journal of Electromagnetic Engineering and Science 22, no. 1 (January 31, 2022): 56–63. http://dx.doi.org/10.26866/jees.2022.1.r.61.

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This paper proposes a control method for an active shield system using an independent power source under misalignment conditions. The proposed method controls the current strength and phase of the shielding system according to magnetic field leakage characteristics with high shielding performance (SP) under misalignment conditions. The current strength and phase of the shielding system were determined by the current strength and mutual inductance of the wireless power transfer (WPT) and shielding coils. Additionally, we considered x and y misalignment conditions and analyzed SP and power transfer efficiency (PTE). The proposed method was verified through simulations and experiments in terms of SP and PTE. The experiments confirmed that, due to the shielding system control, SP increased from 49.22% to 61.74% under misalignment conditions, but there was no additional PTE reduction due to shielding coil control under these conditions.
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Yaghoobzadeh, Ameneh, Saeed Pahlevan Sharif, Fon Sim Ong, Andrew Soundy, Hamid Sharif Nia, Mohammad Moradi Bagloee, Mahnaz Sarabi, Amir Hossein Goudarzian, and Hadi Morshedi. "Cross-Cultural Adaptation and Psychometric Evaluation of the Herth Hope Index Within a Sample of Iranian Older Peoples." International Journal of Aging and Human Development 89, no. 4 (December 20, 2018): 356–71. http://dx.doi.org/10.1177/0091415018815239.

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There is a need to better understand the measurement of hope within a variety of cross-cultural contexts and older population. The objective of this study was to examine the psychometric characteristics of the Persian translation of the Herth Hope Index (HHI-Persian). This study used a sample of 500 Iranian older people in Iran. Psychometric properties of the HHI-Persian were evaluated using face, content, and construct validity. The construct validity of the instrument was tested using exploratory and confirmatory factor analysis. Reliability assessed is within the acceptable range. Construct validity of the scale showed two factors explaining 49.22% of the variance. Internal consistency of 12 items was greater than .70. The HHI-Persian is a short, reliable, and valid assessment scale of hope in older people. The article ends with suggestions for further research.
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Das, Dulal Chandra, Mamun Al Mahtab, Md Abdur Rahim, Debraj Malakar, Anwarul Kabir, and Salimur Rahman. "Hepatitis B virus remains the leading cause of cirrhosis of liver in Bangladesh." Bangladesh Medical Journal 45, no. 3 (July 5, 2017): 164–66. http://dx.doi.org/10.3329/bmj.v45i3.33137.

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Cirrhosis is a serious and irreversible disease. It is a consequence of chronic liver disease characterized by replacement of liver tissue by fibrotic scar tissue as well as regenerative nodules, leading to progressive loss of liver function. Present study was conducted to evaluate the aetiological factors of liver cirrhosis. This was a retrospective cross-sectional study. Patients attending Hepatology Green Unit, Bangabandhu Sheikh Mujib Medical University, Dhaka in 2014 with cirrhosis were included. Total 770 patients were studied, 525(68.18%) males and 245(31.82 %) females. Majority of patients, 379(49.22%) had HBV infection, 162(21.04%) had NASH, 113(14.68%) had HCV infection, 31(4.02%) had alcohol abuse, 28(3.64%) had Wilson’s disease , 23(2.98%) had autoimmune hepatitis and no etiological factors (cryptogenic) were recorded in 34 (4.42%) patients. HBV infection was the major risk factor for cirrhosis in our patients.Bangladesh Med J. 2016 Sep; 45 (3): 164-166
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Liu, Si Qing, Wan Ping Wang, Jian Yang, and Jia Gui You. "Beneficiation of a Low Grade Titanomagnetite Ore in Mining Engineering." Advanced Materials Research 577 (October 2012): 187–90. http://dx.doi.org/10.4028/www.scientific.net/amr.577.187.

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Beneficiation of a low-grade titanomagnetite ore containing 18.52%Fe and 6.65%TiO2 was conducted by dry and wet low intensity magnetic separators. Effects of different variables, such as magnetic intensity, grinding fineness and stages of separation, were investigated in details. The ore was firstly preconcentrated by a dry low-intensity magnetic separator (DLMS) at a magnetic intensity of 2500Oe, and then ground to -0.074mm 53%, followed by a wet low-intensity magnetic separator (WLMS) to recover iron minerals. An iron concentrate assaying 49.22% Fe can be obtained at a recovery of 46.23%. The concentrate was further ground to -0.074mm 70%, followed by two stages of WLMS, and a marketable iron concentrate assaying 56.24% Fe and 9.44% TiO2 can be obtained at the recovery of 42.89% and 20.69%, separately. Tailings assaying 6.48% TiO2 with a recovery of 79.31% is subject to be further recovered.
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Cutini, S., S. Ciprini, M. Orienti, A. Tramacere, F. D'Ammando, F. Verrecchia, G. Polenta, et al. "Radio–gamma-ray connection and spectral evolution in 4C +49.22 (S4 1150+49): the Fermi, Swift and Planck view." Monthly Notices of the Royal Astronomical Society 445, no. 4 (November 7, 2014): 4316–34. http://dx.doi.org/10.1093/mnras/stu2011.

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28

Tanner, Scott, and Robin Lorenz. "Altered intestinal homing molecule expression prevents effective Treg trafficking in the FVB.mdr1a-/- model of colitis. (49.22)." Journal of Immunology 184, no. 1_Supplement (April 1, 2010): 49.22. http://dx.doi.org/10.4049/jimmunol.184.supp.49.22.

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Abstract The FVB.mdr1a-/- mouse, lacking the small molecule pump P-glycoprotein, is a commonly used model for the study of spontaneous T cell mediated colitis. Our lab has shown that a defect in regulatory T cells (Treg) in this model could be a cause of disease. One possible mechanism for the defect in immune regulation is the inability of Tregs to traffic to the gut where they are needed to effectively maintain homeostasis. To investigate this, we examined the numbers of Tregs within various lymphoid organs in the FVB.mdr1a-/- mice. While splenic Treg percentages remained similar between knockout and wild type controls, a decrease in Treg percentages was observed within the MLN, Peyer’s patches and lamina propria. We then adoptively transferred FVB effector T cells (Teff) + FVB or FVB.mdr1a-/- Treg cells into FVB.Rag-/- recipients. After 4 weeks, tissue was harvested to monitor Treg trafficking. Significantly fewer Tregs were observed in the lamina propria of FVB.mdr1a-/- recipients (9.47±5.26% vs. 2.83±0.70%). In addition, FVB.mdr1a-/- Treg recipients showed significantly less expression of the gut homing receptors CCR9 (63.36±3.85% vs. 29.69±2.19%) on splenic Tregs and α4β7 (49.85±2.49% vs. 12.26±5.61%) within lamina propria Tregs. Interestingly, an increase in total splenic cell numbers was observed in the recipients of FVB.mdr1a-/- Tregs. This suggests mdr1a deficient Tregs remain in the spleen and are unable to utilize CCR9 and α4β7 to traffic to the intestine.
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Ihwanudin, Idris. "Migrasi Internasional dan Kondisi Kesehatan Anak yang Ditinggalkan di Jawa Barat dan Jawa Timur." Populasi 27, no. 1 (September 15, 2019): 17. http://dx.doi.org/10.22146/jp.49522.

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International migration affects children who are left behind in their homes. One of the impacts is the health conditions of migrant children. When a child is left by a parent to migrate, the daily activities and life of the child will become a little lame due tono role ofone or both parents who care for and care for health, education, and behavior. This article discusses the impact of international migration on parents on children's health conditions and health behavior and care of migrant children. The data used is the result of CHAMPSEA 2016 study which focuses on the conditions of children and families of international migrants. The results show that international parental migration didnot have a major influence on the health conditions of children, migrant children only experience mild health problems without experiencing serious health problems,such as severe illness and physical / mental disabilities. The behavior of migrant children towards health and the role of caregivers of migrant children contributedto the child's health condition. Good health behavior of migrant children and good care still does not rule out the possibility of developing mild health problems.
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FUKAI, Junya, Toshihide TSUJIMOTO, Ryo YOSHIMURA, Masaki RAIMURA, Toshikazu KUWATA, Genhachi HYOTANI, Michio YABUMOTO, Toru ITAKURA, and Ichiro KAMEI. "Timing of Craniotomy in a Patient With Multiple Trauma Including Head Injury." Neurologia medico-chirurgica 49, no. 1 (2009): 22–25. http://dx.doi.org/10.2176/nmc.49.22.

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31

Afifi, Alan Abdu Robbi, Sarjiya Sarjiya, and Yusuf Susilo Wijoyo. "Ant Colony Optimization for Resolving Unit Commitment Issues by Considering Reliability Constraints." IJITEE (International Journal of Information Technology and Electrical Engineering) 2, no. 4 (November 11, 2019): 120. http://dx.doi.org/10.22146/ijitee.49422.

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Unit Commitment or generator scheduling is one of complex combination issues aiming to obtain the cheapest generating power total costs. Ant Colony Optimization is proposed as a method to solve Unit Commitment issues because it has a better result convergence according to one of journals that reviews methods to solve Unit Commitment issues. Ant Colony Optimization modification into Nodal Ant Colony Optimization as well as addition of several elements are also conducted to overcome Ant Colony Optimization limitations in resolving Unit Commitment issues. Nodal Ant Colony Optimization simulations are then compared with Genetic Algorithm and Simulated Annealing methods which previously has similar simulations. Reliability index combination in a form of Loss of Load Probability and Expected Unserved Energy are also added as reliability constraints in the system. Comparison of three methods shows that Nodal Ant Colony Optimization is able to provide better results up to 0.08% cheaper than Genetic Algorithm or Simulated Annealing methods.
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Sezaki, Hitomi, Fumitaka Suzuki, Norio Akuta, Yusuke Kawamura, Hiromi Yatsuji, Tetsuya Hosaka, Masahiro Kobayashi, et al. "Influence of HMG-CoA reductase inhibitor to virological response of peginterferon/ribavirin combination therapy in chronic hepatitis C." Kanzo 49, no. 1 (2008): 22–24. http://dx.doi.org/10.2957/kanzo.49.22.

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33

Khalipova, N. V. "INTERNATIONAL LOGISTICS SYSTEMS DESIGN AND EFFECTIVENESS EVALUATION." Science and Transport Progress. Bulletin of Dnipropetrovsk National University of Railway Transport, no. 4(58) (September 10, 2015): 142–52. http://dx.doi.org/10.15802/stp2015/49222.

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34

Cansiz, Kadir, Ahmet Yedekci, Huseyin Sen, Sezai Ozkan, and Guner Dagli. "The Effect of Ultrasound Guided Transversus Abdominis Plane Block for Cesarean Delivery on Postoperative Analgesic Consumption." Gulhane Medical Journal 57, no. 2 (2015): 121. http://dx.doi.org/10.5455/gulhane.49122.

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35

Takahashi, Takeshige, Yoshiko Harada, Masaru Ueki, and Takami Kai. "Effect of Sulfur Compound Addition on Hydrodesulfurization of Coker Gas Oil." Journal of the Japan Petroleum Institute 49, no. 1 (2006): 22–27. http://dx.doi.org/10.1627/jpi.49.22.

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36

BOICHARD, Didier. "LA SÉLECTION GÉNOMIQUE, UNE OPPORTUNITÉ POUR AMÉLIORER LA SANTÉ DES ANIMAUX D'ÉLEVAGE." Bulletin de l'Académie vétérinaire de France, no. 1-4 (2013): 25. http://dx.doi.org/10.4267/2042/49222.

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37

Scott, Andrew M., Timothy Akhurst, Fook-Thean Lee, Marika Ciprotti, Ian D. Davis, Andrew J. Weickhardt, Hui K. Gan, et al. "First clinical study of a pegylated diabody 124I-labeled PEG-AVP0458 in patients with tumor-associated glycoprotein 72 positive cancers." Theranostics 10, no. 25 (2020): 11404–15. http://dx.doi.org/10.7150/thno.49422.

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38

Peng, Liyuan, Jingwen Jiang, Bo Tang, Edouard C. Nice, Yuan-Yuan Zhang, and Na Xie. "Managing therapeutic resistance in breast cancer: from the lncRNAs perspective." Theranostics 10, no. 23 (2020): 10360–77. http://dx.doi.org/10.7150/thno.49922.

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39

KAMON, Masashi, Takeshi KATSUMI, and Kazuto MIYATAKE. "Ground Improvement. Performance of Cement-Bentonite Slurry Wall against Heavy Metals Containment." Journal of the Society of Materials Science, Japan 49, no. 1 (2000): 22–25. http://dx.doi.org/10.2472/jsms.49.22.

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40

Srisorrachatr, Siriwan, and Paranee Sriromreun. "Removal of Acid Blue 158 from Solution by Sunflower Seed Hull." ASEAN Journal of Chemical Engineering 13, no. 1 (September 25, 2013): 25. http://dx.doi.org/10.22146/ajche.49722.

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The removal of Acid Blue 158, acid dye for textile dyeing, from aqueous solution by sunflower seed hull was studied. The extent of adsorption capacity was studied as a function of heating temperature, sulphuric acid treatment, adsorbent size and pH of the solution. Sunflower seed hull was heated at 200, 300 and 400oC in oxygen deficient conditioned furnace. As the results, the sunflower seed hull heated at 200oC was the best absorbent for the dye removal with the maximum value of 30.84% at pH 4. Furthermore, removal ratio of Acid Blue 158 increased when the adsorbent was treated with 2M sulphuric acid. Particle sizes examined in this study were 250-355, 710-2000 and over 2000 micrometer. It was showed that the size of adsorbent affected on the removal capacity, i.e. the removal capacity increased along with the decrease of the size of absorbent. pH of the solution was studied between 1 and 6, and it was found that the optimum pH was pH 2. At the optimum condition, the modified adsorbent showed the removal ability of about 50%. The results obtained under the conditions of pH 4, 2M H2SO4 treatment of sunflower seed hull and the size of 500-710 micrometer at room temperature, the adsorption isotherm was fitted to Langmuir adsorption model, and the maximum adsorption capacity, qm, of 18.52 mg/g and Langmuir adsorption constant, Kl, of 5.25x10-3 L/mg were obtained.
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AYDINER, Hasan Malik. "ULUSLARARASI MARKALARIN REKLAMLARI GÖSTERGEBİLİMSEL YÖNTEMLE İNCELENMESİ VE KARMA REKLAM OLGUSUNUN ORTAYA KONULMASI." Journal of Academic Social Science Studies Year: 14 - Number: 86, Year: 14 - Number: 86 (2021): 515–33. http://dx.doi.org/10.29228/jasss.49422.

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KELEŞ, Bahattin. "SANAYİ DEVRİMİNİN OSMANLI EKONOMİSİ ÜZERİNDEKİ ETKİSİ VE CUMHURİYET DÖNEMİ EKONOMİK POLİTİKALARINA YANSIMALARI (1876-1938)." Journal of Academic Social Science Studies Year: 14 - Number: 86, Year: 14 - Number: 86 (2021): 373–88. http://dx.doi.org/10.29228/jasss.49822.

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VURAL, Tanju DEMİR Sevda DEMİR Ömer Faruk. "2016 SONRASI HİZMETİÇİ EĞİTİM MAKALELERİNİN EĞİLİMLERİ." Journal of Academic Social Sciences 113, no. 113 (2021): 468–95. http://dx.doi.org/10.29228/asos.49022.

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Okada, Akihiro, Kensuke Tobitani, Atsushi Ishida, Lisa Park, and Noriko Nagata. "Taking Advantage of Three-Dimensional Computer Graphic Technologies for Development of Base Makeup Products —Associating the Optical Properties of Pearls with User Evaluation—." Journal of Society of Cosmetic Chemists of Japan 49, no. 1 (2015): 22–31. http://dx.doi.org/10.5107/sccj.49.22.

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Kobayashi, Yoshinori. "Full-balanced Occlusion or Lingualized Occlusion?" Nihon Hotetsu Shika Gakkai Zasshi 49, no. 1 (2005): 22–25. http://dx.doi.org/10.2186/jjps.49.22.

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Hemmi, Shoji, Ken Inoue, Yumiko Kutoku, Mitsue Rikimaru, Tatufumi Murakami, and Yoshihide Sunada. "Two brothers with very late onset of muscle weakness in X-linked recessive spinal and bulbar muscular atrophy." Rinsho Shinkeigaku 49, no. 1 (2009): 22–26. http://dx.doi.org/10.5692/clinicalneurol.49.22.

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MIYAZAWA, Kei, Atsushi TANIGUCHI, Toshiyuki OHKAMI, Masashi TOYOTA, Hitoshi TAKEUCHI, and Norikazu YOSHIZAWA. "Estimation of three-dimensional sliding plane geometry using ground surface displacement data." Journal of the Japan Landslide Society 49, no. 1 (2012): 22–35. http://dx.doi.org/10.3313/jls.49.22.

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48

Sage, Stewart. "An update on The Journal of Physiology." Physiology News, Winter 2002 (January 1, 2003): 22–23. http://dx.doi.org/10.36866/pn.49.22.

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49

Endo, Osamu, Kazutoshi Sugita, Sumio Goto, Takashi Amagai, and Hidetsuru Matsushita. "Mutagenicity of Size-Fractioned Airborne Particles Collected with Andersen Low Pressure Impactor." JOURNAL OF HEALTH SCIENCE 49, no. 1 (2003): 22–27. http://dx.doi.org/10.1248/jhs.49.22.

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Murashita, Hidekazu, Shuho Tanaka, Masae Komeno, Keiji Tabuchi, and Akira Hara. "Endoscopic Antrochoanal Polyp Removal Using Endoscopically Guided Canine Fossa Puncture." Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology) 49, no. 1 (2010): 22–25. http://dx.doi.org/10.7248/jjrhi.49.22.

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