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Published: 7 July 2024

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1

Yang, Dachun, and Yong Lin. "SPACES OF LIPSCHITZ TYPE ON METRIC SPACES AND THEIR APPLICATIONS." Proceedings of the Edinburgh Mathematical Society 47, no. 3 (October 2004): 709–52. http://dx.doi.org/10.1017/s0013091503000907.

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AbstractNew spaces of Lipschitz type on metric-measure spaces are introduced and they are shown to be just the well-known Besov spaces or Triebel–Lizorkin spaces when the smooth index is less than 1. These theorems also hold in the setting of spaces of homogeneous type, which include Euclidean spaces, Riemannian manifolds and some self-similar fractals. Moreover, the relationships amongst these Lipschitz-type spaces, Hajłasz–Sobolev spaces, Korevaar–Schoen–Sobolev spaces, Newtonian Sobolev space and Cheeger–Sobolev spaces on metric-measure spaces are clarified, showing that they are the same space with equivalence of norms. Furthermore, a Sobolev embedding theorem, namely that the Lipschitz-type spaces with large orders of smoothness can be embedded in Lipschitz spaces, is proved. For metric-measure spaces with heat kernels, a Hardy–Littlewood–Sobolev theorem is establish, and hence it is proved that Lipschitz-type spaces with small orders of smoothness can be embedded in Lebesgue spaces.AMS 2000 Mathematics subject classification: Primary 42B35. Secondary 46E35; 58J35; 43A99

2

Grilli, Matteo. "Book review: John Aerni-Flessner, Dreams for Lesotho: Independence, Foreign Assistance, and Development." Insight on Africa 12, no. 1 (January 2020): 65–68. http://dx.doi.org/10.1177/0975087819899510.

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John Aerni-Flessner, Dreams for Lesotho: Independence, Foreign Assistance, and Development. Notre Dame: University of Notre Dame Press, 2018, p. 284, Hardcover $55.00, eBook (PDF) $43.99, eBook (EPUB) $43.99, ISBN-10: 0268103615; ISBN-13: 978-0268103613.

3

Abrams, Benjamin. "Book Review." Contention 9, no. 2 (December 1, 2021): 87–90. http://dx.doi.org/10.3167/cont.2021.090206.

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McKee Hurwitz, Heather. 2020. Are We the 99%? The Occupy Movement, Feminism and Intersectionality. Philadelphia, PA: Temple University Press. 208 pp, index. EAN: 978-1-4399-2021-3 (hardback), $99.50; EAN: 978-1-4399-2022-0 (paperback), $25.95.

4

Mrs. M.B.C. Scholten van Aschat and J.F.M. Honig en T. Reichardt. "’G.J.A.B. / ruilverkaveling ‘Borculo’’ (TvAR 1990/4399)." Tijdschrift voor Agrarisch Recht 50, no. 10 (October 1, 1990): ㅤ. http://dx.doi.org/10.5117/tvar1990.10.002.

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5

Hirvi, Laura. "Steven Vertovec. Transnationalism." Suomen Antropologi: Journal of the Finnish Anthropological Society 34, no. 3 (January 1, 2009): 84–85. http://dx.doi.org/10.30676/jfas.116550.

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6

Thoms, Victoria. "Choreomania: Dance and Disorder, Kélina Gotman (2018)." Journal of Dance & Somatic Practices 13, no. 1 (December 1, 2021): 273–75. http://dx.doi.org/10.1386/jdsp_00061_5.

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7

De Brouwer, Samuel. "Review of "Marcel Gauchet and the Crisis of Democratic Politics" edited by Natalie J. Doyle and Sean McMorrow." Politikon: The IAPSS Journal of Political Science 57 (May 16, 2024): 58–60. http://dx.doi.org/10.22151/politikon.57.r1.

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8

Kärki, Kimi. "Metal on Merseyside: Music Scenes, Community and Locality, Nedim Hassan (2021)." Metal Music Studies 9, no. 1 (March 1, 2023): 131–34. http://dx.doi.org/10.1386/mms_00099_5.

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Wettengel, Michael, and Oliver Zimmer. "Rezension von: Zimmer, Oliver, Remaking the Rhythms of Life." Ulm und Oberschwaben 58 (July 17, 2023): 494–95. http://dx.doi.org/10.53458/uo.v58i.6936.

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Oliver Zimmer: Remaking the Rhythms of Life. German Communities in the Age of the Nation-State (Oxford Studies in Modern European History). Oxford: Oxford University Press 2013; XIV, 395 S., geb., 43,99 EUR

10

Lima-Galindo, Anabell Andrea, Adalberto Santana-Guitiérrez, Alejandra de la O-Escamilla, Alejandra Villarreal-Martinez, Sonia Chávez-Álvarez, Jorge Ocampo-Candiani, and Jorge Ocampo-Candiani. "43699 Two cases of Nicolau syndrome: an avoidable entity." Journal of the American Academy of Dermatology 89, no. 3 (September 2023): AB101. http://dx.doi.org/10.1016/j.jaad.2023.07.407.

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11

Caple, Helen. "To See and Be Seen: The Environments, Interactions and Identities behind News Images, T. J. Thomson (2019)." Australian Journalism Review 42, no. 2 (November 1, 2020): 335–36. http://dx.doi.org/10.1386/ajr_00045_5.

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Review of: To See and Be Seen: The Environments, Interactions and Identities behind News Images, T. J. Thomson (2019) London and New York: Rowman & Littlefield Publishers, 186 pp., ISBN 978-1-78661-282-3, ebk, $43.99

12

Nabb, David. "Music, Disability, and Society. By Alex Lubet." Medical Problems of Performing Artists 29, no. 2 (June 1, 2014): 118–19. http://dx.doi.org/10.21091/mppa.2014.2025.

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13

Davidson, Richard J. "Synaptic Substrates of the Implicit and Explicit Self." Science 296, no. 5566 (April 12, 2002): 268. http://dx.doi.org/10.1126/science.296.5566.268.

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Synaptic Self How Our Brains Become Who We Are. Joseph LeDoux. Viking, New York, 2002. 416 pp. $29.95, C$43.99. ISBN 0-670-03028-7. LeDoux combines perspectives from neuroscience, philosophy, literature, and the history of science to explain how human personalities are created by our brains (and, in particular, by the synaptic connectivity within them).

14

Meesters, Gert, David Miranda-Barreiro, and Jakob Dittmar. "Book Reviews." European Comic Art 15, no. 2 (September 1, 2022): 132–40. http://dx.doi.org/10.3167/eca.2022.150207.

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Philippe Delisle and Benoît Glaude, Jijé: L’Autre père de la BD francobelge (Montrouge, France: PLG, 2019). 180 pp. ISBN: 97829178Nhora Lucía Serrano, ed., Immigrants and Comics: Graphic Spaces of Remembrance, Transaction, and Mimesis (New York: Routledge, 2021). 268 pp. ISBN: 9781138186156 (Hardback: £120; e-book: £27.74)Johannes C. P. Schmid, Frames and Framing in Documentary Comics (London: Palgrave Studies in Comics and Graphic Novels, 2021). 292 pp. ISBN: 9783030633035 (e-book: £43.99)

15

Irisawa-Yamaki, Eriko, Shunichi Numata, Minoru Takahashi, Weidong Wu, and Akira Hino. "ICONE19-43499 Experimental Study on Diffusion of Metals in Lead-Bismuth Eutectic in A Thin Tube." Proceedings of the International Conference on Nuclear Engineering (ICONE) 2011.19 (2011): _ICONE1943. http://dx.doi.org/10.1299/jsmeicone.2011.19._icone1943_199.

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16

Wolf-Powers, Laura. "Local Protest, Global Movements: Capital, Community, and State in San Francisco, by KarlBeitel. 2013. Philadelphia, PA: Temple University Press. 220 + x. ISBN: 1-4399-0995-4, $29.95 (paper); ISBN: 1-4399-0994-6, $79.50 (cloth); ISBN 1-4399-0996-2, $29.95." Journal of Regional Science 54, no. 4 (September 2014): 722–24. http://dx.doi.org/10.1111/jors.12153.

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17

Romao, Tico, Libby Saxton, Pete Turner, and Kristen Whissel. "Book Reviews." Projections 17, no. 3 (December 1, 2023): 83–101. http://dx.doi.org/10.3167/proj.2023.170305.

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Kathryn Millard. Double Exposure: How Social Psychology Fell in Love with the Movies. New Brunswick: Rutgers University Press, 2022, 170 pp., $29.95 (paperback), ISBN: 9781978809451. Wyatt Moss-Wellington. Cognitive Film and Media Ethics. New York: Oxford University Press, 2021, 208 pp., $43.99 (paperback), ISBN: 9780197552896. Mathias Clasen. A Very Nervous Person's Guide to Horror Movies. New York: Oxford University Press, 2021, 208 pp, $14.99 (softcover), ISBN: 9780197535905. Carl Plantinga. Alternative Realities. New Brunswick: Rutgers University Press, 2020, 168 pp., $21.95 (paperback), ISBN: 9780813599816.

18

Halomoan, Nico. "The Potential For Implementing Zero Waste Practices Based on the Composition of Domestic Waste in The Hospital (Case study: Bandung Adventist Hospital)." Jurnal Rekayasa Hijau 5, no. 1 (April 5, 2021): 91–100. http://dx.doi.org/10.26760/jrh.v5i1.91-100.

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ABSTRAKRumah Sakit Advent Bandung sebagai salah satu rumah sakit swasta di Kota Bandung dalam kegiatannya menghasilkan sejumlahsampah medis dan sampah domestik. Sampah domestik rumah sakit meningkat dengan bertambahnya jumlah rumah sakit. Inisiatif zero waste berpotensi mengurangi limbah yang akan dibuang keTPA. Limbah padat yang dihasilkan terdiri dari berbagai komposisi yang dapat digunakan untuk mencari potensi reduksi, penggunaan kembali atau daur ulang. Penghitungan timbulan limbah padat domestik dilakukan dengan pendekatan SNI 19-3964-1994, sampel diambil dari dapur dan non dapur. Komposisi sampah dipilah menurut jenis dan potensi zero waste dilihat dari komposisinya. Sampah yang dihasilkan rumah sakit adalah 0,39 kg / tempat tidur / hari untuk dapur, 1,08 kg/bed/hari untuk non dapur dan untuk semua sumber sampah sebanyak 1,47 kg /bed/ hari, lebih rendah dari standar WHO 3,2 kg/bed/hari. Komposisi sampah adalah plastik(17,66%) kertas (8,25%), sampah organik (43,99%), logam (0,41%), karton (9,37%), residu (17,61%) dan lain-lain. (2,71%). Rumah Sakit Advent Bandung telah memulai beberapa upaya untuk minimasi pemborosan. Penerapan zero waste dengan pemisahan sampah selanjutnya dapat diolah sesuai dengan karakteristik masing-masing jenis sampah. Sampah plastik, kertas dan karton dapat dipisahkan untuk didaur ulang. Sampah organik berupa sisa-sisa makanan seperti beras dapat dipisahkan untuk pakan ternak, dicerna dan dibuat kompos.Kata kunci: komposisi, rumah sakit, sampah domestik,minimasi, zero-waste ABSTRACTBandung Adventist Hospital as one of the private hospitals in Bandung City in its activities produces subtantial amount of medical and domestic solid waste. The hospital's domestic solid waste increases with the increase in the number of hospitals. Zero waste initiative can potentially reduce waste to be disposed of in the TPA. The resulting solid waste consists of various compositions that can be used to seek potential for reduction, reuse or recycling. Domestic solid waste generation is calculated using the SNI 19-3964- 1994 approach, samples are taken from kitchens and non-kitchens. The composition of waste is sorted by type and the potential for zero waste seen from the composition. The waste generated by hospital is 0.39 kg/bed/day for kitchen, 1.08 kg/bed/day for non-kitchen and for all source of waste total 1.47 kg/bed/day, lower than the WHO standard 3.2 kg/bed /day. The composition of the waste were plastic (17.66%), papers (8.25%), organic waste (43.99%), metal (0,41%), cardboard (9,37%), residue (17,61%) and others (2,71%). Bandung Adventist Hospital has started several efforts to minimize waste. Zero waste application with separated waste can then be processed according to the characteristics of each type of waste. Plastic, paper and cardboard waste can be separated for recycling. Organic waste in the form of food scraps such as rice can be separated for animal feed, digested and composted.Keywords: composition, hospital, domestic waste, minimize, zero-waste,

19

Latuheru, Silvia D., Hanike Monim, and Muhammad Jen Wajo. "Evaluasi karkas berdasarkan umur dan bobot badan ternak sapi di Kabupaten Manokwari." Jurnal Ilmu Peternakan dan Veteriner Tropis (Journal of Tropical Animal and Veterinary Science) 14, no. 1 (March 31, 2024): 1–10. http://dx.doi.org/10.46549/jipvet.v14i1.320.

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Abstract The aim of the research was to study the quality of livestock production in relation to carcass quality and body weight. The research was conducted descriptively using exploratory techniques on cattle and their products (carcasses). Research for 1 (one) month at the cattle slaughtering location in Manokwari district, namely the first slaughtering location is Transito Wosi, the second slaughtering location is Rendani and the third location is Wosi Market. Samples were obtained randomly by selecting 86 male cattle which were slaughtered with the following criteria: Age 1-2 years, Age 2-3 years, Age 3-4 years, Age 4-5 years and Age > 5 years. The results of this study indicate that the percentage of cattle slaughtered is based on age, namely 2-3 years of 67.44%, 3-4 years of 43.99%, while the highest carcass weight is in the 3-4 year age category of 162.89 ± 77. 32 kg, and the longest carcass length in the 4-5 year old cattle category was 122.40 ± 11.80 cm. Slaughter weight has a close relationship (94.72%) with carcass weight, carcass percentage and carcass length. Differences in age category had no effect on carcass weight, carcass length and carcass percentage. Body weight is strongly influenced by body length and chest circumference. It is necessary to carry out further research with observations starting from livestock rearing, feed given, livestock handling before to after slaughter, carcass quality (thickness of fat, area of rib eye veins). Keywords: Beef cattle; Carcass; Morphometric Abstrak Penelitian bertujuan mempelajari mutu produksi ternak dengan hubungannya dengan kualitas karkas serta berat badan. Penelitian dilakukan secara deskriptif dengan teknik eksplorasi pada ternak sapi dan produknya (karkas). Penelitian selama 1 (satu) bulan pada lokasi pemotongan ternak sapi kabupaten manokwari yaitu lokasi pemotongan I adalah Transito Wosi, lokasi pemotongan II adalah Rendani dan lokasi III adalah Pasar Wosi. Sampel diperoleh secara acak dengan memilih 86 ekor ternak jantan yang disembelih dengan kriteria: Umur 1-2 tahun, Umur 2-3 tahun, Umur 3-4 tahun, Umur 4-5 tahun dan Umur > 5 tahun. Hasil penelitian ini menujukan bahwa Bahwa presentase sapi yang dipotong berdasarakan umur yakni 2 -3 tahun sebesar 67,44%, 3-4 tahun 43,99%, sedangkan bobot karkas tertinggi pada kategori umur 3-4 tahun sebesar 162,89±77,32 kg, serta panjang karkas terpanjang pada kategori umur sapi 4-5 tahun sebesar 122,40±11,80 cm. Bobot potong memiliki hubungan yang erat (94,72 %) dengan bobot karkas, persentase karkas dan panjang karkas. Perbedaan kategori umur tidak berpengaruh terhadap bobot karkas, panjang karkas dan persentase karkas. Bobot badan sangat dipengaruhi oleh panjang badan dan lingkar dada. Perlu dilakukan penelitian lebih lanjut dengan pengamatan yang dimulai dari pemeliharaan ternak, pakan yang diberikan, penanganan ternak sebelum sampai sesudah ternak dipotong, kualitas karkas (tebal lemak, luas urat daging mata rusuk). Kata kunci: Karkas; Morfometrik; Sapi potong

20

Pixley, Jessica, Christina Kontzias, Steven Feldman, and Rita Pichardo. "43099 Understanding the Role of Physician Specialty on Future Hidradenitis Suppurativa Disease Severity." Journal of the American Academy of Dermatology 89, no. 3 (September 2023): AB102. http://dx.doi.org/10.1016/j.jaad.2023.07.410.

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21

Park, Minjun, Susie Suh, Arash Babadjoui, and Natasha Atanaskova. "43399 Growing uses of PRP: an evaluation of hair growth in cicatricial alopecia." Journal of the American Academy of Dermatology 89, no. 3 (September 2023): AB171. http://dx.doi.org/10.1016/j.jaad.2023.07.687.

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22

Arifin, Bastian, Rosnani Nasution, Novi Desrianti, Marianne Marianne, and Hira Helwati. "Antimicrobial Activity of Hand Lotion of Flower Mimusops elengi." Open Access Macedonian Journal of Medical Sciences 7, no. 22 (November 14, 2019): 3748–56. http://dx.doi.org/10.3889/oamjms.2019.496.

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BACKGROUND: Aceh is a tropical region that is very many overgrown by various plants that have medicinal properties; one of them is M. elengi. M. elengi flower extract has the main content of triterpene and alcohol, that have antibacterial, antifungal, antioxidant and antineoplastic activity. Extraction of chemical compounds containing essential oils generally uses distillation, and get the small amounts of chemical compounds, while the maceration with n-hexane solvent, producing less active nonpolar compounds against S. aureus bacteria. AIM: Isolating the methanol extract from M. elengi flowers and test its antibacterial and antifungal activity. Furthermore, extracts with active concentrations are made into a lotion. METHODS: Methanol extract from M. elengi flower was characterised by gas chromatography-mass spectrometry, then tested for antibacterial and antifungal, then made into the lotion. The lotion was tested again for its antimicrobial activity, physical and organoleptic properties. RESULTS: The most abundant chemical compounds in an extract of M. elengi based on characterisation with GC-MS is Borneol L; (Bicyclo [2.2.1] heptane-2-ol, 1,7,7-trimethyl, as much as 82%). The methanol extract of M. elengi flower can inhibit the growth of S. aureus bacteria and C. albicans fungi, and also the lotion from methanol extract can inhibit the growth of S. aureus bacteria, but the M. elengi flower extract lotion cannot inhibit the growth of C. albicans fungi. The lotion inhibits the growth of S. aureus bacteria, from a concentration of methanol extract of 8% and 16%. Lotion with 16% methanol extract has 81.33% in activity power compared with positive control. The results of physical and organoleptic properties test, with the concentration of methanol extract of M. elengi 1, 2, 8, and 16%, have pH in the range of 6.6-8 (still in a safe range, 4.5-9 according to SNI 16-4399-1997). The lotion type is m/a, the spreading capacity of the lotion is 18.8 - 39.5 cm2. The power of adhesive at skin ranges from 1 minute 27 seconds to 3 minutes 7 seconds. The viscosity of the lotion ranges from 23,670-24,400 cP, this range is in the range based on SNI 16-4399-1996 (2000-50,000 cP), so the lotion is in a good category. The preferred lotion is at a concentration of 2%, in fragrance. CONCLUSION: Antibacterial activity of the lotion of methanol extract of M. elengi flower against S. aureus bacteria was the best at 16%, but could not inhibit the growth of C. albicans fungi. The most abundant compounds in methanol extract are Borneol L compounds; (Bicyclo [2.2.1] heptane-2-ol, 1,7,7-trimethyl. In general, the physical properties of this lotion meet the requirements of SNI16-4399-1996, SNI 16-4399-1997, and lotions which are preferred at a concentration of 2% in fragrance.

23

Ni'mah, Gusti Khairun, and Muhammad Syarif Djaya. "KANDUNGAN ACID DETERGENT FIBER (ADF) DAN NEUTRAL DETERGENT FIBER (NDF) PADA RUMPUT Brachiaria humidicola PADA UMUR DEFOLIASI BERBEDA." ZIRAA'AH MAJALAH ILMIAH PERTANIAN 49, no. 1 (January 26, 2024): 127. http://dx.doi.org/10.31602/zmip.v49i1.13773.

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This study aims to determine the content of neutral detergent fibre (NDF) and acid detergent fibre (ADF) of Brachiaria humidicola grass at different depoliation ages. This research is a pure experiment using the Completely Randomized Design (CRD) method with three treatments (40 days, 50 days and 60 days) and three replications. The results showed that depoliation age had no significant effect (P>0.05) on the NDF and ADF content of Brachiaria humidicola grass with NDF values ranging from 64.20% to 65.49%, while ADF values ranged from 36.75% to 43.99%.

24

Momin, Bahar, Tue Felix Nguyen, Anaya Shah, and John C. Browning. "43199 Analyzing Follow-Up Rates and Barriers to Care in Student-Run Free Clinic." Journal of the American Academy of Dermatology 89, no. 3 (September 2023): AB16. http://dx.doi.org/10.1016/j.jaad.2023.07.071.

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25

Chen, Ping Hua, Xue Zhen Zhou, Yong Xiu Li, Dong Ping Li, Jing Li, and Yan Zhu Liu. "Kinetic and Thermodynamic Study Adsorbing Methylene Blue on Nanozirconia." Applied Mechanics and Materials 475-476 (December 2013): 1311–19. http://dx.doi.org/10.4028/www.scientific.net/amm.475-476.1311.

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In present study, uniformed nanozirconia is obtained via precipitation, ball milling and spray drying. The characteristics of methylene blue adsorption by nanozirconia are studied in details. The morphology of nanozirconia is examined by SEM. The influence of temperature is studied to obtain the optimal adsorption conditions. The equilibrium adsorption isotherms and the kinetic properties of the adsorption process are investigated to study the mechanism. The thermodynamic properties of methylene blue adsorption is investigated, and the thermodynamic parameters of Gθ, Hθ and Sθ are calculated. The results show nanozirconia has high adsorption ability of 43.99 mg/g to methylene blue, and the adsorption reaction is a spontaneous and physic-sorption process.

26

Lyasota, V., N. Bogatko, N. Bukalova, V. Dzhmil, O. Khitska, T. Mazur, S. Tkachuk, T. Prilipko, and S. Giptenko. "Safety and quality of sweet and cream oil of various domestic manufacturers and determining its falsification." Naukovij vìsnik veterinarnoï medicini, no. 1(173) (June 24, 2022): 33–42. http://dx.doi.org/10.33245/2310-4902-2022-173-1-33-42.

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The entry of domestic products into European markets has set Ukrainian entrepreneurs the task - to increase their production, ensure safety, quality and competitiveness. The purpose of the study is to assess the safety and quality of sweet butter obtained from various domestic producers, and to determine its falsification by the generally accepted method and the developed patented express method. The object of the study was the assessment of organoleptic, physicochemical, microbiological parameters and falsification of sweet butter obtained from various milk processing enterprises of Ukraine: Lustdorf LLC and Fooddevelopment LLC, Vinnytsia region; TDV "Yagotinsky butter factory"; PE "SIMOL", Kyiv region; State Enterprise "Starokostiantyniv Dairy Plant", Khmelnytsky region. Analytical, organoleptic (appearance, color, consistency, smell, taste) were used to achieve the research goal; physicochemical (mass fraction of moisture, mass fraction of fat, titrated acidity of plasma oil and acidity of fatty phase of oil, mass fraction of sodium chloride, determination of margarine and vegetable fats), microbiological (KMAFАNM, the presence of Escherichia coli bacteria, pathogenic microorganisms, in particular genus Salmonella, species Listeria monocytogenes; molds) and variation-statistical research methods. Developed patented express method for detecting adulteration of sweet cream oil using resorcinol solution in benzene with a mass fraction of 5.0% and concentrated hydrochloric acid can be used in production laboratories at milk and dairy products, supermarkets, wholesale bases, shops and public laboratories. in laboratories of veterinary and sanitary examination in agro-industrial markets. The oil produced by different manufacturers according to organoleptic parameters: appearance, color, texture, smell and taste met the requirements of DSTU 4399: 2005. According to physical and chemical parameters, the samples of sweet butter also met DSTU 4399: 2005, except for sample № 5 (SE "Starokostiantyniv Dairy Plant" of Khmelnytsky region), which showed an increase of + 0.6% by weight of sodium chloride. Research has established the falsification of sweet cream oil according to the developed patented method, according to which the probability in the indicators was 99.9%, produced: TDV "Yagotinsky butter factory" - up to 1.5% (light purple color) oil and "Farm Peasant", manufacturer LLC Food Development "- from 1.6 to 5.0% (bright purple color). Microbiological parameters of sweet butter: KMAFANM, bacteria of the Escherichia coli group, bacteria of the genus Salmonella, species Listeria monocytogenes, as well as molds met the requirements of DSTU 4399: 2005. Key words: sweet and butter, dairy processing enterprises of Ukraine, organoleptic, physicochemical, microbiological indicators, falsification, safety, quality.

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Han, George, Mark Lebwohl, Andrea Murina, and Abby Jacobson. "43299 Improvement in Itch, Dryness, and Stinging/Burning With and Without Study-Defined Treatment Success." Journal of the American Academy of Dermatology 89, no. 3 (September 2023): AB178. http://dx.doi.org/10.1016/j.jaad.2023.07.713.

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28

Ibekwe, Opuruiche, Carmelo Gaudioso, Kristopher M. Attwood, Ellis G. Levine, Stephen B. Edge, and Chukwumere E. Nwogu. "Abstract 4399: Can technology improve the quality and efficiency of multidisciplinary cancer conferences." Cancer Research 83, no. 7_Supplement (April 4, 2023): 4399. http://dx.doi.org/10.1158/1538-7445.am2023-4399.

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Abstract Background: The use of multidisciplinary cancer conferences (MCCs) in cancer patient management is known to lead to improved quality of care and patient outcomes. Applying technology to MCCs may serve to optimize the process and enhance its contribution to patient care. The purpose of this study is to evaluate the impact of a tumor board technology platform on the quality of MCCs. Methods: Data was collected prospectively from Thoracic, Gynecology (GYN) and Breast Cancer MCCs, September 2020 to February 2022, at a comprehensive cancer center using an MCC performance assessment tool and a self-administered survey. The Mann Whitney U and X2 tests were used as appropriate, to compare the quality of information presented and discussed, time per case reviewed, and consensus before and after implementation of the NAVIFY® Tumor Board Solution. Weighted composite scores of 11 of the variables were calculated and averaged between observers. Higher mean scores reflect higher quality and vice versa. Results: Pre and post NAVIFY® data were collected from 249 and 289 cases, respectively. The overall quality of information presented increased after NAVIFY® implementation (Table 1). This increase was maintained within the Thoracic, Breast and GYN MCC subgroups (mean composite scores: 63.9 vs 82.9; p < .001, 63.4 vs 72.3; p < .001, and 59.8% vs 63.5%; p = 0.009 respectively). Increased participation by surgical, medical and radiation oncologists was also documented for the MCCs (mean score: 3.9 vs 4.1; p < .001, 3.4 vs 3.9; p < .001, and 3.5 vs 3.6; p = 0.035 respectively) as well as increased frequency of consensus (85.9% to 95.5%; p = 0.001). No change in discussion time was seen. Pathologists/radiologists surveyed reported greater ease of finding information they needed to prepare for the MCC (76.1% vs 96.7%; p = 0.048). Conclusions: Using technology to organize and convey data at MCCs improves quality of information presented and discussed, clinician participation and the ability to reach a consensus. Table 1. Comparison of Observational Measures Before and After NAVIFY® Platform Introduction Baseline Period Post Period P-value Total Observed Cases N 250 (46.4%) 289 (43.6%) Observed Cases By MCC Thoracic 156 (62.4%) 177 (61.2%) 0.963 Breast 42 (16.8%) 50 (17.3%) GYN 52 (20.8%) 62 (21.5%) All MCCs Composite Score Mean/SD 62.9/7.7 76.9/10.6 <.001 Composite Score Breakdown >= 90 - 26 (9.0%) <.001 80-90 9 (3.6%) 100 (34.6%) 70-80 28 (11.2%) 84 (29.1%) 60-70 132 (52.8%) 57 (19.7%) < 60 81 (32.4%) 22 (7.6%) Surgical Oncologist Contribution Mean/SD 3.9/0.8 4.1/0.7 <.001 Medical Oncologist Contribution Mean/SD 3.4/1.0 3.9/1.0 <.001 Radiation Oncologist Contribution Mean/SD 3.5/0.9 3.6/1.2 0.035 Discussion Time (minutes) Mean/SD 10.2/4.4 10.3/4.3 0.605 Consensus Reached Yes 213 (85.9%) 276 (95.5%) 0.001 Citation Format: Opuruiche Ibekwe, Carmelo Gaudioso, Kristopher M. Attwood, Ellis G. Levine, Stephen B. Edge, Chukwumere E. Nwogu. Can technology improve the quality and efficiency of multidisciplinary cancer conferences. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4399.

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Tumbelaka, Riddel M. M. Y., Lidya I. Momuat, and Audy D. Wuntu. "PEMANFAATAN VCO MENGANDUNG KAROTENOID TOMAT DAN KARAGENAN DALAM PEMBUATAN LOTION." PHARMACON 8, no. 1 (February 28, 2019): 94. http://dx.doi.org/10.35799/pha.8.2019.29242.

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ABSTRACT Research has been conducted on the making of Lotion using VCO containing Tomato Carotenoids and Carrageenan with a mass concentration of 3%. The stability of Lotion is determined by the stability of the emulsion in the Lotion preparation. The resulting Lotion was tested for quality according to SNI 16-4399-1996 standards, namely pH, density, viscosity, and total microbial test. In addition, the resulting Lotion was tested for total carotenoids based on the reading results of UV-Vis Spectrophotometry. The results showed that the highest carotenoids in A1 samples were 129.99 mg / L and the lowest was in A6 samples 38.15 mg / L. And the results of the Lotion quality test found in Lotion by using carrageenan were better than Lotion using cetyl alcohol. Keywords: VCO, carrageenan, carotenoids, Lotion, SNI ABSTRAK Telah dilakukan penelitian tentang Pembuatan Lotion menggunakan VCO mengandung Karotenoid Tomat dan Karagenan dengan konsentrasi massa 3%. Kestabilan dari Lotion ditentukan dengan kestabilan emulsi dalam sediaan Lotion. Lotion yang dihasilkan diuji kualitas menurut standar SNI 16-4399-1996 yaitu uji pH, massa jenis, viskositas, dan total mikroba. Selain itu, Lotion yang dihasilkan diuji total karotenoid berdasarkan hasi pembacaan Spektrofotometri UV-Vis. Hasil penelitian menunjukkan bahwa yang memiliki Karotenoid tertinggi pada sampel A1 sebanyak 129,99 mg/L dan terendah pada sampel A6 38,15 mg/L. Dan hasil uji kualitas Lotion didapati Lotion dengan menggunakan karagenan lebih baik dibandingkan dengan Lotion menggunakan setil alkohol. Kata kunci: VCO, karagenan, karotenoid, Lotion, SNI

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Hudairiah, Nunung Nurhaijah, S. Rosalinda, and Asri Widyasanti. "Formulasi Handbody Lotion (Setil Alkohol dan Karagenan) dengan Penambahan Ekstrak Delima Merah." Jurnal Teknotan 15, no. 1 (August 23, 2021): 41. http://dx.doi.org/10.24198/jt.vol15n1.7.

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Delima merah mengandung antioksidan vitamin C yang berfungsi untuk mencegah oksidasi, penuaan, dan regenerasi sel. Ekstrak delima merah dapat dimanfaatkan sebagai bahan alami dalam handbody lotion. Handbody lotion merupakan kosmetik yang mengandung banyak air berbentuk emulsi tipe minyak dalam air yang diaplikasikan pada kulit bagian tangan dan tubuh. Salah satu bahan penyusun handbody lotion adalah setil alkohol yang berfungsi sebagai pengemulsi, pengental, dan penstabil yang dapat digantikan oleh karagenan. Penelitian ini bertujuan untuk menentukan konsentrasi terbaik dari setil alkohol dan karagenan serta penambahan ekstrak delima merah pada handbody lotion. Metode penelitian yang digunakan adalah metode eksperimental laboratorium dengan analisis statistik One-Way ANOVA dan uji lanjutan Duncan serta analisis data secara deskriptif. Tahapan penelitian terdiri dari pembuatan handbody lotion menggunakan setil alkohol (0,5%; 0,7%; 1,0%) dan karagenan (1,0%; 2,0%; 3,0%) serta penambahan ekstrak delima merah sebesar 0,2% dan 2,5% pada handbody lotion terbaik yang didapatkan. Hasil penelitian menunjukkan bahwa handbody lotion memenuhi SNI 16-4399-1996 (penampakan, pH, viskositas) dimana handbody lotion terbaik dibuat menggunakan setil alkohol 1,0% (rendemen 92,8%; homogen; pH 8,0; viskositas 4950,0 cP) dan karagenan 3,0% (rendemen 92,5%; homogen; pH 8,0; viskositas 9262,5 cP). Handbody lotion dengan setil alkohol 1,0% dan ekstrak delima merah 0,2% memiliki rendemen 92,5%; homogen; pH 7,0; dan viskositas 4550,0 cP. Handbody lotion dengan karagenan 3,0% dan ekstrak delima merah 2,5% memiliki rendemen 92,5%; homogen; pH 7,0; dan viskositas 5233,3 cP. Penambahan ekstrak delima merah menghasilkan handbody lotion yang memenuhi SNI 16-4399-1996.

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Irmayanti, Maya, S. Rosalinda, and Asri Widyasanti. "Formulasi Handbody Lotion (Setil Alkohol dan Karagenan) dengan Penambahan Ekstrak Kelopak Rosela." Jurnal Teknotan 15, no. 1 (August 26, 2021): 47. http://dx.doi.org/10.24198/jt.vol15n1.8.

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Handbody lotion merupakan kosmetik yang dapat diaplikasikan pada kulit bagian tangan dan tubuh yang berfungsi untuk mengurangi dehidrasi kulit. Setil alkohol pada handbody lotion memiliki fungsi sebagai pengental, penstabil dan pengemulsi, dimana fungsi setil alkohol ini dapat digantikan oleh karagenan. Ekstrak kelopak rosela dengan kandungan vitamin C dapat melindungi kulit dari radikal bebas. Tujuan dari penelitian ini adalah menentukan konsentrasi terbaik dari penggunaan setil alkohol dan karagenan serta penambahan ekstrak kelopak rosela pada handbody lotion. Metode dari penelitian ini adalah analisis data menggunakan One Way ANOVA dan uji lanjutan duncan serta analisis deskriptif. Tahapan dari penelitian adalah penggunaan setil alkohol (0,5%; 0,7%; dan 1%) dan karagenan (1%; 2%; dan 3%) pada pembuatan handbody lotion serta handbody lotion terbaik ditambah dengan ekstrak kelopak rosela 2,5%. Hasil Penelitian menunjukkan bahwa formula handbody lotion yang dibuat memenuhi SNI 4399-1966 (penampakan, pH, dan viskositas) dimana perlakuan terbaik yaitu setil alkohol 1% (rendemen 92,8%; homogen; pH 8,0; viskositas 4950,0 cP) dan karagenan 3% (rendemen 92,5%; homogen; pH 7,0; viskositas 9262,5 cP). Hasil penelitian menunjukkan bahwa sifat fungsional dari setil alkohol dapat digantikan oleh karagenan. Handbody lotion terbaik dengan penggunaan setil alkohol 1% ditambah dengan ekstrak kelopak rosela 2,5% menghasilkan rendemen 92,4%; penampakan homogen;pH 7,0; viskositas 4266,7 cP. Handbody lotion dengan penggunaan karagenan 3% ditambah dengan ekstrak kelopak rosela 2,5% menghasilkan rendemen 92,4%; penampakan homogen; pH 7,0; viskositas 5216,7 cP. Penambahan ekstrak kelopak rosela menghasilkan handbody lotion yang memenuhi standar SNI 4399-1996.

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Parker, Amanda. "Computers and the human brain." Nature 401, no. 6748 (September 1999): 15. http://dx.doi.org/10.1038/43299.

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Liebl, Ursula, Gérard Lipowski, Michel Négrerie, Jean-Christophe Lambry, Jean-Louis Martin, and Marten H. Vos. "Coherent reaction dynamics in a bacterial cytochrome c oxidase." Nature 401, no. 6749 (September 1999): 181–84. http://dx.doi.org/10.1038/43699.

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Fromhold, T. M., F. W. Sheard, L. Eaves, and P. B. Wilkinson. "Have quantum scars been observed?" Nature 387, no. 6636 (June 1997): 864. http://dx.doi.org/10.1038/43099.

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Barkai, N., and S. Leibler. "Robustness in simple biochemical networks." Nature 387, no. 6636 (June 1997): 913–17. http://dx.doi.org/10.1038/43199.

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Wang, Jitao, Zhenke Wu, Sung Won Choi, Srijan Sen, Xinghui Yan, Jennifer A. Miner, Angelle M. Sander, Angela K. Lyden, Jonathan P. Troost, and Noelle E. Carlozzi. "The Dosing of Mobile-Based Just-in-Time Adaptive Self-Management Prompts for Caregivers: Preliminary Findings From a Pilot Microrandomized Study." JMIR Formative Research 7 (September 14, 2023): e43099. http://dx.doi.org/10.2196/43099.

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Background Caregivers of people with chronic illnesses often face negative stress-related health outcomes and are unavailable for traditional face-to-face interventions due to the intensity and constraints of their caregiver role. Just-in-time adaptive interventions (JITAIs) have emerged as a design framework that is particularly suited for interventional mobile health studies that deliver in-the-moment prompts that aim to promote healthy behavioral and psychological changes while minimizing user burden and expense. While JITAIs have the potential to improve caregivers’ health-related quality of life (HRQOL), their effectiveness for caregivers remains poorly understood. Objective The primary objective of this study is to evaluate the dose-response relationship of a fully automated JITAI-based self-management intervention involving personalized mobile app notifications targeted at decreasing the level of caregiver strain, anxiety, and depression. The secondary objective is to investigate whether the effectiveness of this mobile health intervention was moderated by the caregiver group. We also explored whether the effectiveness of this intervention was moderated by (1) previous HRQOL measures, (2) the number of weeks in the study, (3) step count, and (4) minutes of sleep. Methods We examined 36 caregivers from 3 disease groups (10 from spinal cord injury, 11 from Huntington disease, and 25 from allogeneic hematopoietic cell transplantation) in the intervention arm of a larger randomized controlled trial (subjects in the other arm received no prompts from the mobile app) designed to examine the acceptability and feasibility of this intensive type of trial design. A series of multivariate linear models implementing a weighted and centered least squares estimator were used to assess the JITAI efficacy and effect. Results We found preliminary support for a positive dose-response relationship between the number of administered JITAI messages and JITAI efficacy in improving caregiver strain, anxiety, and depression; while most of these associations did not meet conventional levels of significance, there was a significant association between high-frequency JITAI and caregiver strain. Specifically, administering 5-6 messages per week as opposed to no messages resulted in a significant decrease in the HRQOL score of caregiver strain with an estimate of –6.31 (95% CI –11.76 to –0.12; P=.046). In addition, we found that the caregiver groups and the participants’ levels of depression in the previous week moderated JITAI efficacy. Conclusions This study provides preliminary evidence to support the effectiveness of the self-management JITAI and offers practical guidance for designing future personalized JITAI strategies for diverse caregiver groups. Trial Registration ClinicalTrials.gov NCT04556591; https://clinicaltrials.gov/ct2/show/NCT04556591

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Horst, Rebecca, Lea-Mara Witsch, Rayford Hazunga, Natasha Namuziya, Gardner Syakantu, Yusuf Ahmed, Omar Cherkaoui, Petros Andreadis, Florian Neuhann, and Sandra Barteit. "Evaluating the Effectiveness of Interactive Virtual Patients for Medical Education in Zambia: Randomized Controlled Trial." JMIR Medical Education 9 (June 29, 2023): e43699. http://dx.doi.org/10.2196/43699.

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Background Zambia is facing a severe shortage of health care workers, particularly in rural areas. Innovative educational programs and infrastructure have been established to bridge this gap; however, they encounter substantial challenges because of constraints in physical and human resources. In response to these shortcomings, strategies such as web-based and blended learning approaches have been implemented, using virtual patients (VPs) as a means to promote interactive learning at the Levy Mwanawasa Medical University (LMMU) in Zambia. Objective This study aimed to evaluate the students’ knowledge acquisition and acceptance of 2 VP medical topics as a learning tool on a Zambian higher education e-learning platform. Methods Using a mixed methods design, we assessed knowledge acquisition using pre- and posttests. In a randomized controlled trial setting, students were assigned (1:1) to 2 medical topics (topic 1: appendicitis and topic 2: severe acute malnutrition) and then to 4 different learning tools within their respective exposure groups: VPs, textbook content, preselected e-learning materials, and self-guided internet materials. Acceptance was evaluated using a 15-item questionnaire with a 5-point Likert scale. Results A total of 63 third- and fourth-year Bachelor of Science clinical science students participated in the study. In the severe acute malnutrition–focused group, participants demonstrated a significant increase in knowledge within the textbook group (P=.01) and the VP group (P=.01). No substantial knowledge gain was observed in the e-learning group or the self-guided internet group. For the appendicitis-focused group, no statistically significant difference in knowledge acquisition was detected among the 4 intervention groups (P=.62). The acceptance of learning materials exhibited no substantial difference between the VP medical topics and other learning materials. Conclusions In the context of LMMU, our study found that VPs were well accepted and noninferior to traditional teaching methods. VPs have the potential to serve as an engaging learning resource and can be integrated into blended learning approaches at LMMU. However, further research is required to investigate the long-term knowledge gain and the acceptance and effectiveness of VPs in medical education. Trial Registration Pan African Clinical Trials Registry (PACTR) PACTR202211594568574; https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=20413

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Fritz, Johanna, Petra von Heideken Wågert, Annelie K. Gusdal, Rose-Marie Johansson-Pajala, and Caroline Eklund. "Determinants of Implementing an Information and Communication Technology Tool for Social Interaction Among Older People: Qualitative Content Analysis of Social Services Personnel Perspectives." JMIR Aging 7 (February 26, 2024): e43999. http://dx.doi.org/10.2196/43999.

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Background Older people are particularly vulnerable to social isolation and loneliness, which can lead to ill-health, both mentally and physically. Information and communication technology (ICT) can supplement health and social care and improve health among the vulnerable, older adult population. When ICT is used specifically for communication with others, it is associated with reduced loneliness in older populations. Research is sparse on how the implementation of ICT, used specifically for communication among older people in social services, can be performed. It is recommended to consider the determinants of implementation, that is, barriers to and facilitators of implementation. Determinants related to older people using ICT tools are reported in several studies. To the best of our knowledge, studies investigating the determinants related to the social services perspective are lacking. Objective This study aims to explore the determinants of implementing the Fik@ room, a new, co-designed, and research-based ICT tool for social interaction among older people, from a social services personnel perspective. Methods This study used an exploratory, qualitative design. An ICT tool called the Fik@ room was tested in an intervention study conducted in 2021 in 2 medium-sized municipalities in Sweden. Informants in this study were municipal social services personnel with experience of implementing this specific ICT tool in social services. We conducted a participatory workshop consisting of 2 parts, with 9 informants divided into 2 groups. We analyzed the data using qualitative content analysis with an inductive approach. Results The results included 7 categories of determinants for implementing the ICT tool. Being able to introduce the ICT tool in an appropriate manner concerns the personnel’s options for introducing and supporting the ICT tool, including their competencies in using digital equipment. Organizational structure concerns a structure for communication within the organization. Leadership concerns engagement and enthusiasm as driving forces for implementation. The digital maturity of the social services personnel concerns the personnel’s skills and attitudes toward using digital equipment. Resources concern time and money. IT support concerns accessibility, and legal liability concerns possibilities to fulfill legal responsibilities. Conclusions The results show that implementation involves an entire organization at varying degrees. Regardless of how much each level within the organization comes into direct contact with the ICT tool, all levels need to be involved to create the necessary conditions for successful implementation. The prerequisites for the implementation of an ICT tool will probably change depending on the digital maturity of future generations. As this study only included 9 informants, the results should be handled with care. The study was performed during the COVID-19 pandemic, which has probably affected the results.

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Madikizela, Balungile, Tamira Eckhardt, Richard Goddard, Adrian Richter, Anika Lins, Christoph Lehmann, Peter Imming, and Rüdiger W. Seidel. "Synthesis, structural characterization and antimycobacterial evaluation of several halogenated non-nitro benzothiazinones." Medicinal Chemistry Research 30, no. 8 (June 10, 2021): 1523–33. http://dx.doi.org/10.1007/s00044-021-02735-4.

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Abstract8-Nitro-1,3-benzothiazin-4-ones (BTZs), with BTZ043 and PBTZ169 as the most advanced compounds, represent a new class of potent antitubercular agents, which irreversibly inhibit decaprenylphosphoryl-β-d-ribose-2′-epimerase (DprE1), an enzyme crucial for cell wall synthesis in the pathogen Mycobacterium tuberculosis. Synthesis, structural characterization and in vitro testing against Mycobacterium aurum DSM 43999 and M. tuberculosis H37Rv of halogenated 2-(4-ethoxycarbonylpiperazin-1-yl)-1,3-benzothiazin-4-ones lacking a nitro group are reported. X-ray crystallography reveals that the structure of the BTZ scaffold can significantly deviate from planarity. In contrast to recent reports, the results of the present study indicate that further investigation of halogenated non-nitro BTZs for antitubercular activity is less than a promising approach.

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Rodríguez, Batista Zenón, and Romário Cerqueira Leite. "Ocorrência de vetores biológicos da Dermatobia hominis (L.Jr., 1781) (Díptera: Cuterebridae), capturados com armadilha magoom na região metalúrgica do estado de Minas Gerais, Brasil." Ciência Rural 27, no. 4 (December 1997): 645–49. http://dx.doi.org/10.1590/s0103-84781997000400021.

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Através do uso da armadilha Magoam foram capturados 49.010 insetos no período de junho de 1995 a maio de 1996 no município de Pedro Leopoldo MG. Foram identificadas 10 ordens de insetos. Destes, 95,73% pertencem à ordem Díptera. Três famílias, Sepsidae, Syrphidae e Culicidae participaram com 24,65%, 18,53%, e 17,64% respectivamente dos 46.915 dípteros capturados. Dos três locais pesquisados, a mata (local 3) contribuiu com o maior número de insetos capturados correspondentes a 43,99% do total de espécimes colhidos. Os vetares biológicos de D. hominis (com postura aderida) importantes por ordem de frequência foram Fannia spp, Musca domestica, Stomoxys calcitrans, Synthesiomyia nudiseta, Ophira sp., sendo esta última notificada pela primeira vez. O gênero Fannia spp. apresentou-se como de maior importância epidemiológica por sua maior frequência e distribuição nos locais de captura.

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Karadağ, Şule, and Abdullah Koçak. "The role of inter family communication in marital adjustment: Case of Konya." Journal of Human Sciences 14, no. 2 (April 9, 2017): 1093. http://dx.doi.org/10.14687/jhs.v14i2.4072.

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This is a descriptive research carried out among 827 people residing in Konya city. The mean marital adjustment scale (MAS) score was 43.99 based on the survey and marital adjustment scale application, and 56.0% of respondents were compatible with their marriage while 44.0% of them were incompatible. However, it was determined that communication between spouses (problem sharing, sadness / distress sharing, discussion frequency, remaining separate after discussion, solving problems after discussion, sharing sexual problems, devoting some time for each other, dealing with emotions and thoughts of the spouses) significantly affected the marital adjustment.In conclusion, the findings show that the communication between couples and within family is related with marital adjustment. it would be helpful to carry out studies and researches to improve communication skills at the centers working with the families and marriage counseling centers.

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Wagner, Christina, K. Eckardt, D. Tresselt, W. Ihn, G. Schumann, and W. F. Fleck. "Leukaemomycin-geblockte Mutanten desStreptomyces griseus und ihre Pigmente III. 11-Desoxydaunomycinonderivate aus der Mutante ZIMET 43699/G44." Journal of Basic Microbiology 25, no. 10 (1985): 687–93. http://dx.doi.org/10.1002/jobm.3620251021.

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Díaz-Del Cerro, E., C. Vida, I. Martínez de Toda, and M. De La Fuente. "Abstract #4399 Immune function improvement after sleeping on a system of insulation against electromagnetic fields." Brain, Behavior, and Immunity 81 (October 2019): 53. http://dx.doi.org/10.1016/j.bbi.2019.08.175.

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Mou, Haiwei, Kristen DeRosa, Veronika Yakovishina, Yeqing Chen, Abdiel Mandella Reynolds, Min Xiao, Monzy Thomas, and Meenhard Herlyn. "Abstract 4399: HMGA1 is an epigenetic regulator and plays a critical role in melanoma recurrence." Cancer Research 84, no. 6_Supplement (March 22, 2024): 4399. http://dx.doi.org/10.1158/1538-7445.am2024-4399.

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Abstract Among various genetic mutation in melanoma, BRAFV600E is one of the key drivers of melanoma initiation and progression and has become the frontline target in clinical trials. Although BRAF/MEK inhibitors show very promising therapeutic outcomes, recurrence or relapse is still a major challenge and its underlying mechanisms are still poorly understood. We hypothesized that survival of recurrent tumors is BRAF independent and relies on epigenetic reprogramming. To test our hypothesis, we used either pharmacological inhibition of BRAF/MEK or CRISPR/Cas9 mediated knockout of BRAF to create cell/tumor models of BRAF-independent survival. Cut&Run sequencing was then used to identify epigenetic alterations regulated by H3K4me3 or H3K27Ac in a genome scale and capture the landscape of epigenetic alterations of BRAF-independent cell survival. Combining regular bulk RNAseq, we narrowed down our top candidates and focused on one of the functionally validated candidates, HMGA1. Interestingly, CRISPR/Cas9 mediated HMGA1 knockout cells show significantly slower growth in both in vitro colony formation assays and in vivo xenografts assay in BRAF/MEK resistant Patient-Derived-Xenograft (PDX) tumor models resembling melanoma recurrence. Furthermore, we selected CRISPR/Cas9 single knockout cells of HMGA1, which is a pure genetic depletion model, and confirmed the phenotype of impaired tumor growth of HMGA1 knockout cells. We then performed RNAseq and ChIPseq, and identified downstream targets of HMGA1 and elucidated mechanisms by which HMGA1 reprograms epigenetics of recurrence. Utilizing the single knockout cell, we re-introduced HMGA1 in the pure knockout cells, and anticipated that restoration of HMGA1 in pure HMGA1 knockout cells rescues impaired tumor growth and confer cells resistance to BRAF/MEK inhibition. Finally, we subcutaneously injected the HMGA1 single knockout cells into humanized mice and tested whether epigenetic alterations perturb the immune microenvironment and sensitize cells to immunotherapy. In conclusion, this study sheds new lights on how melanoma cells reprogram the epigenome to develop mechanisms of recurrence. Identification of HMGA1 and its upstream or downstream targets provides potential druggable targets of overcoming relapse after BRAF/MEK inhibitor therapy. Citation Format: Haiwei Mou, Kristen DeRosa, Veronika Yakovishina, Yeqing Chen, Abdiel Mandella Reynolds, Min Xiao, Monzy Thomas, Meenhard Herlyn. HMGA1 is an epigenetic regulator and plays a critical role in melanoma recurrence [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 4399.

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Krisyanella, Krisyanella, Resva Meinisasti, and Silvi Elvianita. "FORMULATION OF LOTION OF GERGA ORANGE PEEL ETHANOL EXTRACT WITH VARIATION OF EXTRACT CONCENTRATION." Proceeding B-ICON 1, no. 1 (December 20, 2022): 233–39. http://dx.doi.org/10.33088/bicon.v1i1.41.

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Gerga Orange (Citrus nobilis L. Var. RGL) are the main commodity in Lebong Regency, Bengkulu Province. These oranges have been processed by the community into syrup preparations and from this activity produce waste in the form of fruit peels. Based on previous research, the peel of this citrus fruit is known to have antioxidant and antibacterial activity, so it can be used as a raw material in the manufacture of lotion preparations. The purpose of this study was to determine the characteristics of the three lotion formulations from the ethanolic extract of the gerga orange peel (Citrus nobilis L. Var. RGL) with various concentrations of 8% (F1), 10% (F2), 12% (F3). The method used is the experimental method. The results showed that the three formulations of lotion met the standard of good lotion. In the organoleptic test, there were differences in the color of the preparation, where the color became more concentrated as the concentration of the extract increased. In the homogeneity test, the three formulas showed good homogeneity until the 14th day of testing. The pH of the three formulas was also in accordance with the SNI 16-4399-1996 standard, namely 4.5-8. The three formulas also did not cause allergic reactions to 10 respondents. Based on the results of the research that has been done, it can be concluded that all formulas of the ethanol extract of the gerga orange peel (Citrus nobilis L. Var. RGL) with varying concentrations can be formulated as lotion preparations that are physically and organoleptically stable, as well as the standard of SNI 16-4399-1996 in terms of pH of the preparation and irritation test. Of the three formulas, formula 1 has an advantage over the other formulas because it has a less intense color, which makes it superior in appearance.

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Bhut, JB, DV Khanpara, AM Bharadiya, and RB Madariya. "Effectiveness of different storage bags against Caryedon serratus (Oliver) (Coleoptera: Bruchidae) in storage condition." Journal of Phytopharmacology 10, no. 6 (December 25, 2021): 520–24. http://dx.doi.org/10.31254/phyto.2021.10616.

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Laboratory experiments on effectiveness of different storage bags against the groundnut Bruchid, Caryedon serratus in storage condition was carried out at Main Oilseeds Research Station, Junagadh Agricultural University, Junagadh during 2016 and 2017. All the treatments were significantly superior over untreated check (i.e., Traditional jute gunny bags). Results of the experiment indicated that the lowest per cent pod damage was recorded in the treatments of high-density polythene (HDPE) bags (Adults unreleased), polythene layered gunny bags (Adults unreleased), fertilizer bags (Adults unreleased) and triple layered gunny bags (Adult unreleased) at 30, 60, 90 and 120 days days of trial installation. The high-density polythene (HDPE) bags (Adult unreleased) have also higher net gain as well as ICBR (1: 52.52) followed by high density polythene (HDPE) bags (Adult released) (1: 43.99) and polythene layered gunny bags (Adult unreleased) (1: 30.01).

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Sultonov, B. E., E. S. Nozimov, and D. S. Kholmatov. "Recycling of Local Phosphate Waste - mineralized Mass into Activated Phosphorus Fertilizers." Chemical Science International Journal 32, no. 6 (December 14, 2023): 108–14. http://dx.doi.org/10.9734/csji/2023/v32i6875.

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The manuscript provides the results of the process of obtaining activated phosphorus fertilizer (APF) by nitric acid processing of mineralized mass (MM) of phosphate waste, which formed during the sorting stage of thermal beneficiation of Central Kyzylkum (CK) phosphorites. For experiments was used MM with content 14.60% P2O5total(t.).; 3.07% P2O5acceptable by citric acid (ac.c.a.); 43.99% CaOt.; 1.01% MgO; 14.11% CO2; 1.04% Al2O3; 0.89% Fe2O3; 1.58% SO3; 1.30% F; 1.02% H2O; CaO:P2O5 – 3.01 and 10.82% insoluble residual. The optimal concentrations and norms of nitric acid have been determined. Phosphorus fertilizer suspensions were neutralized with Ca(OH)2 suspension in order to prevent P2O5 from passing into the solution. APF obtained in optimal parameters has the following composition (weight, %): 20.42-20.58 P2O5total(t.); 11.02-11.72 P2O5ac.c.a.; 38.87-39.01CaOt.; 23,39-24,48 CaO ac.c.a.. The degree of transition of P2O5 to liquid phase is 2.02-2.06%.

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Lord, Robyn. "The Equine Industry: Competing Beliefs, Change and Conflict." Muma Business Review 3 (2019): 099–120. http://dx.doi.org/10.28945/4399.

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Fifty million years ago, the equine is chronicled in the early days of Eohippus, the earliest known horse to man. In the 1400s, Cortez and Christopher Columbus transported the first domestic horses to the Americas. Ancient times supported the use of horses in times of war where the industry began utilizing the horse as a vehicle. Today, the equine industry is strongly steeped in traditions and cultural beliefs that prove consistent to the early rituals. However, within the last few decades, the equine industry started to see a radical new change to the age-old tradition of horsemanship. This new sub-culture is called natural horsemanship. This movement, as it was called in the beginning, challenged tradition and millions of years of beliefs. Why did some adopt and others not? The focus on this study is to define the industry, creating a solid picture of how the change began, why the change was necessary in the eyes of some, and what is the current state of the industry as it stands. In this research, the equine industry will serve as an industry model revealing beliefs and cultural frameworks that can serve as a blueprint for other industries who may be experiencing changes to an embedded culture way of doing business. With proposed change comes conflict. The human stress factor, conflict and personal dedication necessary to change decades of tradition is a daunting task. Long-standing belief systems are usually embedded in tradition and society’s acceptance of the status quo. As humans, we initially will resist as change is difficult and takes effort with responsibility. The literature review will provide solid data supporting this industry adaptation, and how it has affected aspects of the industry. Data will also provide the existence of opposing forces: natural versus traditional and what that means for those on each side. While this offers innovative opportunities for some, it has provided deeper traction in regulatory bodies, traditional organizations, and professional treatment of the equine. The equine industry analysis will demonstrate a unique glimpse into an industry at the forefront of possible change, whereas for centuries none had occurred.

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Darabi, Roksana, Sima Tadi, Mitra Mohit, Erfan Sadeghi, Gita Hatamizadeh, Bahareh Kardeh, Mina Etminan-Bakhsh, and Yekta Parsa. "The prevalence and risk factors of group B streptococcus colonization in Iranian pregnant women." Electronic physician 9, no. 5 (May 25, 2017): 4399–404. http://dx.doi.org/10.19082/4399.

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Clarke, R. T., and M. J. Greenacre. "Theory and Applications of Correspondence Analysis." Journal of Animal Ecology 54, no. 3 (October 1985): 1031. http://dx.doi.org/10.2307/4399.

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