Relevant bibliographies by topics / 4-oxadiazole

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Academic literature on the topic '4-oxadiazole'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 March 2023

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Journal articles on the topic "4-oxadiazole"

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Stepanova, Elena V., and Andrei I. Stepanov. "UNUSUAL WAY OF REACTION OF 3-AMINO-4-(5-CHLOROMETHYL-1,2,4-OXADIAZOLE-3-YL)-FURAZAN WITH HYDRAZINE." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 60, no. 4 (May 12, 2017): 26. http://dx.doi.org/10.6060/tcct.2017604.5522.

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The results of our study of the pathways of selective reactivity of 3-amino-4-(5-chloromethyl-1,2,4-oxadiazole-3-yl)furazan versus 5-unsubstituted or 5-methyl and 5-trifluoromethyl substituted 4-(5R-1,2,4-oxadiazole-3-yl)furazans (R = H, Me, CF3) towards the action of hydrazine are discussed. If the reductive opening of 1,2,4-oxadiazole ring in unsubstituted at the С-5 atom (1,2,4-oxadiazol-3-yl)furazan derivatives under the treatment with hydrazine can be used as a method for the preparation of a range of amidrazones of 4-R-furazan-3-carboxylic acid. 3-amino-4-(5-trifluoromethyl-1,2,4-oxadiazol-3-yl)furazan with hydrazine gives amidoxime of 4-aminofurazan-3-carboxylic acid. 3-amino-4-(5-methyl-1,2,4-oxadiazol-3-yl) furazan is inert to the action of hydrazine, on the contrary the reaction of 3-amino-4-(5-chloromethyl-1,2,4-oxadiazole-3-yl)furazan with hydrazine leads to oxidation of chloromethyl group of titled compound to the carbonyl one. In this case the product of reaction of 3-amino-4-(5-chloromethyl-1,2,4-oxadiazole-3-yl)furazan with hydrazine was isolated in a form of corresponding hydrazonomethyl derivative notably as 3-amino-4-(5-hydrazonomethyl-1,2,4-oxadiazole-3-yl)furazan. A possible reaction mechanism for the formation of hydrazonomethyl group by oxidation reaction of chloromethyl group by hydrazine is proposed. 3-Amino-4-(5-hydrazonomethyl-1,2,4-oxadiazol-3-yl)furazan undergoes a transhydrazination reaction with semicarbazide and thiosemicarbazide. But our attempts to its hydrolysis for the purpose to obtain free aldehyde were unsuccessful. Thus, hydrolysis of hydrazonomethyl derivative in acetic acid in the presence of catalytic amount of sulfuric acid results in azine – N,N'-bis(3-(4-aminofurazan-3-yl)-1,2,4-oxadiazol-5-ylmethylyden)hydrazine – precipitation, long-duration boiling in hydrochloric acid leads to Kishner-Wolff reduction of the carbonyl group to 3-amino-4-(5-methyl-1,2,4-oxadiazol-3-yl)furazan, and hydrolysis in alkaline medium leads to 1,2,4-oxadiazole ring opening to amidoxime of 4-aminofurazan-3-carboxylic acid. Synthesis of 3-amino-4-(5-chloromethyl-1,2,4-oxadiazole-3-yl)furazan (R = CH2Cl) was carried out by condensation of amidoxime of 4-aminofurazan-3-carboxylic acid with an excess of chloroacetyl chloride in toluene at elevated temperature. The reaction proceeds through formation of intermediate product – 3-chloromethylamino-4-(5-chloromethyl-1,2,4-oxadiazol-3-yl)furazan. Removing of N-chloroacetyl group in such obtained intermediate was performed by hydrolysis in acidic media. One-pot synthesis without the need for isolation and purification of intermediate is allowed. The structures of obtained compounds were proved by modern methods of physical-chemical analysis (1H, 13C NMR, IR and MS spectroscopy).Forcitation:Stepanova E.V., Stepanov A.I. Unusual way of reaction of 3-amino-4-(5-chloromethyl-1,2,4-oxadiazole-3-yl)furazan with hydrazine. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 4. P. 26-32.
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Saini, Sachin. "Synthesis and Anticonvulsant Studies of Thiazolidinone and Azetidinone Derivatives from Indole Moiety." Drug Research 69, no. 08 (December 20, 2018): 445–50. http://dx.doi.org/10.1055/a-0809-5098.

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Abstract2-Amino-5-(3’-indolomethylene)-1, 3 , 4 - oxadiazole (3) undergoes facile condensation with various aromatic aldehydes to gave 2-substitiuted arylidenylamino-5-(3’- indolomethylene) – 1, 3 , 4 – oxadiazole (4–8). Cyclocondensation of (4–8) with thioglycolic acid and triethylamine yielded 3-[5’-(3”- indolomethylene)- 1’, 3’, 4’- oxadiazol-2’-yl]- 2- (substituted aryl)-4- thiazolidinones (9–13) and 1-[5’-(3”- indolomethylene) -1’, 3’, 4’- oxadiazol - 2’- yl ] -4-(substituted aryl) -2- azetidinones (14–18). The structures of these compounds were established on the basis of analytical and spectral data. The newly synthesised compounds were evaluated for their anticonvulsant activity and acute toxicity.
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Jin, Guoxia, Yuqi Ji, Teng Wang, Yanyan Sun, Yulong Li, Guiying Zhu, and Jianping Ma. "Syntheses and characterization of dinuclear and tetranuclear AgI supramolecular complexes generated from symmetric and asymmetric molecular clips containing oxadiazole rings." Acta Crystallographica Section C Structural Chemistry 75, no. 10 (September 6, 2019): 1327–35. http://dx.doi.org/10.1107/s2053229619011744.

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A new asymmetric ligand, 5-{3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}-2-(pyridin-3-yl)-1,3,4-oxadiazole (L5), which contains two oxadiazole rings, was synthesized and characterized. The assembly of symmetric 2,5-bis(pyridin-3-yl)-1,3,4-oxadiazole (L1) and asymmetric L5 with AgCO2CF3 in solution yielded two novel AgI complexes, namely catena-poly[[di-μ-trifluoroacetato-disilver(I)]-bis[μ-2,5-bis(pyridin-3-yl)-1,3,4-oxadiazole]], [Ag2(C2F3O2)2(C12H8N4O)2] n or [Ag2(μ2-O2CCF3)2(L1)2] n (1), and bis(μ3-5-{3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}-2-(pyridin-3-yl)-1,3,4-oxadiazole)tetra-μ3-trifluoroacetato-tetrasilver(I) dichloromethane monosolvate, [Ag4(C2F3O2)4(C22H15N5O2)2]·CH2Cl2 or [Ag2(μ3-O2CCF3)2(L5)]2·CH2Cl2 (2). Complex 1 displays a one-dimensional ring–chain motif, where dinuclear Ag2(CF3CO2)2 units alternate with Ag2(L1)2 macrocycles. This structure is different from previously reported Ag–L1 complexes with different anions. Complex 2 features a tetranuclear supramolecular macrocycle, in which each ligand adopts a tridentate coordination mode with the oxadiazole ring next to the p-tolyl ring coordinated and that next to the pyridyl ring free. Two L5 ligands are bound to two Ag1 centres through two oxadiazole N and two pyridyl N atoms to form a macrocycle. The other two oxadiazole N atoms coordinate to the two Ag2 centres of the Ag2(O2CCF3)4 dimer. Each CF3CO2 − anion adopts a μ3-coordination mode, bridging the Ag1 and Ag2 centres to form a tetranuclear silver(I) complex. This study indicates that the donor ability of the bridging oxadiazole rings can be tuned by electron-withdrawing and -donating substituents. The emission properties of ligands L1 and L5 and complexes 1 and 2 were also investigated in the solid state.
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El-Sayed, Wael A., Farag A. El-Essawy, Omar M. Ali, Barsis S. Nasr, Mohamed M. Abdalla, and Adel A. H. Abdel-Rahman. "Anti-HIV Activity of New Substituted 1,3,4-Oxadiazole Derivatives and their Acyclic Nucleoside Analogues." Zeitschrift für Naturforschung C 64, no. 11-12 (December 1, 2009): 773–78. http://dx.doi.org/10.1515/znc-2009-11-1203.

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A number of new 5-[(naphthalen-5-yloxy)methyl]-1,3,4-oxadiazole derivatives, 2 - 5 and 8 - 11, were synthesized. The 2-{5-[(naphthalen-5-yloxy)methyl]-1,3,4-oxadiazol-2-ylthio}acetohydrazones 6a and 6b were synthesized by the reaction of the hydrazide 4 with the corresponding monosaccharides. Cyclization of the sugar hydrazones 6a and 6b with acetic anhydride afforded the substituted oxadiazoline derivatives 7a and 7b. The synthesized compounds were evaluated for their antiviral activity against, the human immunodefi ciency virus (HIV-1) and some of these compounds showed moderate to high antiviral activity.
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Ahsan, Mohamed Jawed, Arun Choupra, Rakesh Kumar Sharma, Surender Singh Jadav, Pannala Padmaja, Mohd Zaheen Hassan, Abdulmalik Bin Saleh Al-Tamimi, Mohammed H. Geesi, and Mohammed Afroz Bakht. "Rationale Design, Synthesis, Cytotoxicity Evaluation, and Molecular Docking Studies of 1,3,4-oxadiazole Analogues." Anti-Cancer Agents in Medicinal Chemistry 18, no. 1 (March 16, 2018): 121–38. http://dx.doi.org/10.2174/1871520617666170419124702.

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Background: 1,3,4-Oxadiazole heterocycles possess a broad spectrum of biological activities. They were reported as potent cytotoxic agents and tubulin inhibitors; hence it is of great interest to explore new oxadiazoles as cytotoxic agents targeting tubulin polymerization. Objective: Two new series of oxadiazoles (5a-h and 12a-h) were synthesized, structurally related to the heterocyclic linked aryl core of IMC-038525, NSC 776715, and NSC 776716, with further modification by incorporating methylene linker. Method: The 2,5-disubstituted-1,3,4-oxadiazoles (5a-h and 12a-h) were synthesized by refluxing an equimolar mixture of the intermediates [(4) and (8a-d)] and aromatic aldehydes in water-ethanol system using sodium bisulphite catalyst. The cytotoxicity evaluation was carried out according to the National Cancer Institute (NCI US) Protocol, while the tubulin polymerization assay kits from Cytoskeleton ™(bk011p) was used to perform an in vitro tubulin polymerization assay. Results: 2-(5-{[(4-Chlorophenyl)amino]methyl}-1,3,4-oxadiazol-2-yl)phenol (5f) and 2-[(2,4-dichlorophenoxy) methyl]-5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole (12c) showed maximum cytotoxicity with the mean percent growth inhibitions (GIs) of 71.56 and 72.68 respectively at 10 µM drug concentrations. Both the compounds (5f and 12c) showed superior cytotoxicity than clinically prevalent anticancer drugs, Imatinib and Gefitinib in one dose assay. The compound 12c showed promising results in five dose assay, with GI50 values varies between 1.61 and >100 µM. Furthermore, the compounds, 5f and 12c also inhibited the polymerization of tubulin with, an IC50 of 2.8 and 2.2 µM, respectively. Conclusion: The oxadiazoles reported herein are tubulin inhibitors and cytotoxic agents. These findings will be helpful in future drug design of more potent tubulin inhibitor cytotoxic agents.
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Tang, Yongxing, Chunlin He, Lauren A. Mitchell, Damon A. Parrish, and Jean'ne M. Shreeve. "Energetic compounds consisting of 1,2,5- and 1,3,4-oxadiazole rings." Journal of Materials Chemistry A 3, no. 46 (2015): 23143–48. http://dx.doi.org/10.1039/c5ta06898c.

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3-Nitroamino-4-(5-amino-1,3,4-oxadiazol-2-yl)furazan monohydrate (2·H2O), which is a combination of the nitroaminofurazan and 1,3,4-oxadiazole rings, was obtained by the nitration of 3-amino-4-(5-amino-1,3,4-oxadiazol-2-yl)furazan (1) with 100% nitric acid.
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Mercer, F. W. "Aromatic Poly(ether imide oxadiazole)s." High Performance Polymers 4, no. 2 (April 1992): 73–80. http://dx.doi.org/10.1088/0954-0083/4/2/002.

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Two oxadiazole containing aromatic diamines were synthesized. The diamines were prepared by reaction of aminophenols with 2,5-bis(4-fluorophenyl)-4l3,4-oxadiazole in a polar aprotic solvent in the presence of potassium carbonate. Reaction of the resulting 2,5-bis(4-(aminophenoxy)phenyl)-1,3,4-oxadiazoles with dianhydrides gave a series of polymeric amic acids. Thermal treatment yielded poly(imide ether oxadazole) films which displayed good thermal stability, flexibility, and glass transition temperatures ranging from 241 to 344C. The dielectric constants of the films were characterized as a function of relative humidity.
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Wołek, Barbara, Mateusz Werłos, Magdalena Komander, and Agnieszka Kudelko. "Efficient Synthesis of Novel 1,3,4-Oxadiazoles Bearing a 4-N,N-Dimethylaminoquinazoline Scaffold via Palladium-Catalyzed Suzuki Cross-Coupling Reactions." Molecules 25, no. 21 (November 5, 2020): 5150. http://dx.doi.org/10.3390/molecules25215150.

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Two series of novel (symmetrical and unsymmetrical) quinazolinylphenyl-1,3,4-oxadiazole derivatives were synthesized using palladium-catalyzed Suzuki cross-coupling reactions. The presented synthetic methodology is based on the use of bromine-substituted 2-phenyl-4-N,N-dimethylaminoquinazolines and either a boronic acid pinacol ester or a diboronic acid bis(pinacol) ester of 2,5-diphenyl-1,3,4-oxadiazole. The reactions are conducted in a two-phase solvent system in the presence of catalytic amounts of [1,1′-bis(diphenylphosphino)ferrocene]-dichloropalladium(II), sodium carbonate, and tetrabutylammonium bromide, which plays the role of a phase-transfer catalyst. The luminescence properties of the obtained compounds are discussed in the context of applying these compounds in optoelectronics. Specifically, two highly-conjugated final products: N,N-dimethyl-2-phenyl-6-(4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl)quinazolin-4-amine (8f) and 6,6′-(4,4′-(1,3,4-oxadiazole-2,5-diyl)bis(4,1-phenylene))bis(N,N-dimethylquinazolin-4-amine (9f), which contain a 1,3,4-oxadiazole moiety connected to a quinazoline ring by a 1,4-phenylene linker at the 6 position, exhibit strong fluorescence emission and high quantum yields.
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Epishina, Margarita A., Alexander S. Kulikov, and Leonid L. Fershtat. "4-Amino-3-(1-{[amino(3-methyl-2-oxido-1,2,5-oxadiazol-4-yl)methylene]hydrazinylidene}ethyl)-1,2,5-oxadiazole 2-Oxide." Molbank 2022, no. 3 (August 12, 2022): M1425. http://dx.doi.org/10.3390/m1425.

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Functionally substituted 1,2,5-oxadiazole 2-oxides (furoxans) are important pharmaceutical scaffolds used for the preparation of various pharmacologically active substances. Furoxans bearing hydrazone functionality are considered as promising drug candidates for the treatment of neglected diseases. However, pharmacologically oriented hydrazones derived from (furoxanyl)amidrazones and acetylfuroxans have remained unknown so far. In this communication, a simple method for the synthesis of 4-amino-3-(1-{[amino(3-methyl-2-oxido-1,2,5-oxadiazol-4-yl)methylene]hydrazinylidene}ethyl)-1,2,5-oxadiazole 2-oxide is described. The structure of the synthesized compound was established by elemental analysis, high-resolution mass spectrometry, 1H, 13C NMR and IR spectroscopy.
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Godovikova, T. I., S. K. Vorontsova, L. D. Konyushkin, S. I. Firgang, and O. A. Rakitin. "4-Methyl-1,2,5-oxadiazole-3-carbonitrile in the synthesis of 1,2,5-oxadiazolyl-1,2,4-oxadiazoles." Russian Chemical Bulletin 57, no. 11 (November 2008): 2440–42. http://dx.doi.org/10.1007/s11172-008-0349-4.

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Dissertations / Theses on the topic "4-oxadiazole"

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Kivrak, Arif. "Development Of New Methods For The Synthesis Of Pyrazoles, 4-iodopyrazoles, Isoxazoles And 1,2,4-oxadiazoles." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12612945/index.pdf.

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Synthesis of five-membered heteroaromatic compounds such as pyrazoles, isoxazoles and 1,2,4-oxadiazoles are important for pharmaceutical industry and material science due to their applications. Although there are many methods to prepare such compounds, new variants continue to appear since they exhibit a wide range of biological and medicinal activities. In this thesis, new methods were developed for the synthesis of 4-iodopyrazoles, pyrazoles, isoxazoles, 1,2,4-oxadiazoles and/or 1,2,4-oxadiazepines. In the first part of the study, electrophilic cyclization of &alpha
,&beta
-alkynic hydrazones by molecular iodine and copper iodide were investigated as new ways for the synthesis of 4-iodopyrazoles and pyrazoles, respectively. Initially, &alpha
,&beta
-alkynic hydrazones were prepared by the reactions of propargyl aldehydes and ketones with hydrazines. Then &alpha
,&beta
-alkynic hydrazones were treated with molecular iodine in the presence of NaHCO3, which afforded 4-iodopyrazoles in good to excellent yields. Subsequently, the same reactions were carried out with CuI in the presence of NEt3, which furnished corresponding pyrazoles in good yields. Moreover, ferrocenyl-substituted 4-iodopyrazoles and pyrazole derivatives were synthesized from corresponding
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Le, Falher Laetitia. "Préparation et dérivatisation de 4H-pyrido[e][1,3]oxazinones : une contribution à la diversité chimique." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066344.

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Ce manuscrit porte sur la synthèse et les applications d'une nouvelle série de composés hétéroaromatiques : les 4H-pyrido[e][1,3]oxazin-4-ones. La première partie de ce manuscrit présente la préparation de ces squelettes via une réaction d'O-arylation intramoléculaire. La seconde partie du manuscrit repose sur la réactivité de ces entités chimiques et de leur utilisation en tant qu'intermédiaires de synthèse. La fonctionnalisation des 4H-pyrido[e][1,3]oxazin-4-ones, via des réactions de couplage pallado-catalysées, a permis d'obtenir des systèmes polyfonctionnalisés plus complexes. Les pyrido-oxazinones ont également été transformées, en une étape, en divers petits hétérocycles d'intérêt : les 1,3,5-triazines, les 1,2,4-triazoles et les 1,2,4-oxadiazoles. La dernière partie du manuscrit est consacrée à l'utilisation des molécules synthétisées comme potentielles sondes fluorescentes pour la détection de protéines oxydées
This work focused on the synthesis and applications of a novel series of heteroaromaticcompounds: the 4H-pyrido[e][1,3]oxazin-4-ones. The first part of this thesis presents thepreparation of these pyrido-oxazinones via an intramolecular O-arylation reaction. The secondpart of this work relies on the reactivity of these chemical entities and their use as buildingblocks. The functionalization of the 4H-pyrido[e][1,3]oxazin-4-ones has been studied viacross-coupling reactions to obtain more elaborated structures. The pyrido-oxazinones werealso converted, in one step, into other diverse small molecules of interest: 1,3,5-triazines,1,2,4-triazoles and 1,2,4-oxadiazoles. The last part of this thesis was devoted to the use of theobtained heterocycles as potential fluorescent probes for the detection of carbonylatedproteins
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Singh, Neeraj. "Generation of 4,5-Dihydro-1,2,3-oxadiazole and Study of the Decomposition Products." Doctoral thesis, Universitätsbibliothek Chemnitz, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-191706.

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4,5-Dihydro-1,2,3-oxadiazoles are postulated to be key intermediates in the synthesis of ketones from alkenes on an industrial scale, alkylation of DNA in vivo, decomposition of N-nitrosoureas (potent carcinogens), and are also a subject of great interest for theoretical chemists. In this thesis, formation of the parent compound and decay into secondary products has been studied by NMR monitoring analysis. The elusive properties and the intermediacy of the parent compound, 4,5-dihydro-1,2,3-oxadiazole, in the decomposition of suitably substituted N-nitrosoureas using Tl(I) alkoxides as bases, have been confirmed by the characterisation of its decay products viz., ethylene oxide, acetaldehyde, and especially diazomethane, at very low temperatures by 1H NMR, 13C NMR, 15N NMR, and relevant 2D NMR methods. Moreover, it has been shown that the methylation of nucleophilic molecules by 3-methyl-4,5-dihydro-1,2,3-oxadiazolium salts, which are considered to be activated forms of β−hydroxyalkylnitrosamines, does not involve 4,5-dihydro-1,2,3-oxadiazole as an intermediate, as has been reported in literature; instead, nucleophilic substitution leading to synthesis of open-chain products dominates the reaction
4,5-Dihydro-1,2,3-oxadiazole wurden als Schlüsselintermediate in der industriellen Synthese von Ketonen aus Alkenen, der in vivo Alkylierung von DNA und der Zersetzung von N-Nitrosoharnstoffen (potente Karzinogene) postuliert. Sie sind ebenso von großem Interesse in der theoretischen Chemie. Im Rahmen dieser Arbeit wurde die Bildung der Stammverbindung und deren Zersetzung in sekundäre Produkte mittels NMR-Verfolgung studiert. Die ausgesprochene Kurzlebigkeit der Stammverbindung 4,5-Dihydro-1,2,3-oxadiazol wurde durch die Charakterisierung der Produkte bei der Zersetzung geeignet substituierter N-Nitrosoharnstoffe mit Tl(I)-Alkoxiden bestätigt. Die Zersetzungsprodukte Ethylenoxid, Acetaldehyd und besonders Diazomethan wurden bei sehr niedrigen Temperaturen mittels 1H-NMR, 13C-NMR, 15N-NMR und relevanten 2D-NMR-Methoden charakterisiert. Des Weiteren konnte gezeigt werden, dass die Methylierung nucleophiler Spezies mit 3-Methyl-4,5-dihydro-1,2,3-oxadiazoliumsalzen, welchen als aktivierte Äquivalente der β−Hydroxyalkylnitrosamine verstanden werden, nicht zur Bildung von 4,5-Dihydro-1,2,3-oxadiazol als Intermediat führt, so wie dies in der Literatur berichtet wurde. Stattdessen wird die Bildung offenkettiger Produkte durch nukleophile Substitution bevorzugt
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Wolf, Lucas. "Síntese de heterociclos: 2-alquil/arilcalcogeno-n-(4-aril-1,3-tiazol-2-il)acetamidas e (s)-n-(1-(3-aril-1,2,4-oxadiazol-5-il)alquil)-2-(calcogenofenil) acetamidas derivados de organocalcogênios." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/4271.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
In the present work, a series of 2-alkyl/arylchalcogenide-N-(4-aryl-1,3-thiazol-2-yl)acetamide was prepared via addition of aryl or alkyl chalcogenides. This methodology allowed the preparation of new derivatives of 2-amino-1,3-thiazoles in good yields. The compound synthesized is intended to evaluate the biological potential from the antioxidant activity by scavenging capacity of the assay by ABTS and DPPH. Was also developed a methodology for obtaining the compounds (S)-N-(alkyl-1-(3-aryl-1,2,4-oxadiazol-5-yl)-2-(phenylchalcogenide)acetamide derived from (S)-2-(2-(phenylchalcogenide)acetamido)alkanoic acids and arylamidoximes employing microwave irradiation. This synthesis was carried out in three conditions by varying the reaction time, temperature and solvent. The reactions employing microwave irradiation exhibit advantages against reactions using conventional method. These compounds were characterized by 1H NMR, 13C NMR and techniques high resolution mass spectrometry.
No presente trabalho, uma série de 2-alquil/arilcalcogeno-N-(4-aril-1,3-tiazol-2-il)acetamidas foi preparada via adição de calcogenetos de alquila ou arila. Essa metodologia permitiu a obtenção de derivados de 2-amino-1,3-tiazois em bons rendimentos. A proposta dessa síntese tem a finalidade de avaliar o potencial biológico a partir da atividade antioxidante por meio da capacidade sequestradora dos compostos sintetizados através de ensaios de ABTS e DPPH. Também foi desenvolvido uma metodologia para a obtenção dos compostos (S)-N-(1-(3-aril-1,2,4-oxadiazol-5-il)alquil)-2-(calcogenofenil)acetamidas derivados de ácidos (S)-2-(2-(calcogenofenil)acetamido)alcanoicos e arilamidoximas, empregando irradiação de micro-ondas. Para essa síntese foram desenvolvidas três condições reacionais variando o tempo reacional, temperatura e solvente. As reações conduzidas em micro-ondas apresentaram vantagens frente às reações em método convencional. Estes compostos foram caracterizados por técnicas de RMN 1H, RMN 13C e por espectrometria de massas de alta resolução.
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Paulo, TÃrcio de Freitas. "5-(4-PIRIDIL)-1,3,4-(OXADIAZOL)-2-TIOL E Na3[Fe(CN)5Hpyt].3H2O: SÃntese, caracterizaÃÃo e estudos de formaÃÃo de monocamadas automontadas." Universidade Federal do CearÃ, 2007. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=1418.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico
As espÃcies 5-(4-piridil)-1,3,4-oxadiazol-2-tiol (Hpyt) e [Fe(CN)5Hpyt]3- (FeHpyt) adsorvem espontaneamente sobre ouro formando monocamadas automontadas (SAM - "Self-Assembled Monolayers") das quais, de acordo com os dados eletroquÃmicos, apresentam defeitos ou nanoporos por onde as molÃculas de prova [Fe(CN)6]4â e [Ru(NH3)6]3+ acessam a superfÃcie do eletrodo de ouro policristalino. A partir dessas molÃculas de prova e da dependÃncia entre a corrente faradÃica e o pH do eletrÃlito, o pKa da monocamada de Hpyt foi calculada como 4,2. A partir dos resultados de microscopia de tunelamento STM (Scanning Tunneling Microscopy) obtidos para a monocamada automontada de Hpyt sobre Au(111) foi possÃvel estimar que as molÃculas de Hpyt sÃo adsorvidas em um arranjo hexagonal com um espaÃamento mÃdio entre os Ãtomo de enxofre de 5,5 Ã. Essas imagens tambÃm mostraram a presenÃa de nanoporos, do qual indica que fortes interaÃÃes laterais nÃo ocorrem efetivamente. Os parÃmetros termodinÃmicos ΔHads, ΔGads e ΔSads para o processo de adsorÃÃo das molÃculas Hpyt e FeHpyt foram calculados a partir da correlaÃÃo entre a concentraÃÃo dos adsorbatos na superfÃcie (Γ) e em soluÃÃo (C) para diferentes temperaturas. A quantidade de molÃculas adsorvidas foi calculada a partir do processo de desorÃÃo redutiva, onde R = Hpyt ou FeHpyt, observados em -555 e -566 mV versus Ag|AgCl|Cl- para as monocamadas de Hpyt e FeHpyt, respectivamente, indicando um fortalecimento da ligaÃÃo AuâS como conseqÃÃncia do efeito π-backbonding do centro metÃlico ferro para o ligante Hpyt. A reaÃÃo heterogÃnea de transferÃncia de elÃtrons da metaloproteÃna citocromo c foi satisfatoriamente acessada pelas monocamadas de Hpyt e FeHpyt, apresentando um voltamograma quasi-reversÃvel com potenciais consistentes com a forma nativa desta proteÃna.
-(4-pyridinyl)-1,3,4-oxadiazole-2-thiol (Hpyt) and [Fe(CN)5Hpyt]3- (FeHpyt) species spontaneously adsorbed on gold forming SAM (Self-Assembled Monolayers) that, based on electrochemical data, contain pinholes through which [Fe(CN)6]4â and [Ru(NH3)6]3+ probe molecules access the underlying gold electrode. From the former molecule and the dependence of the faradaic current on the pH value of the electrolyte solution, the surface pKa of the Hpyt SAM was evaluated as 4.2. Taking into account the STM (Scanning tunneling Microscopy) results obtained for the Hpyt SAM on Au(111), it was possible to estimate that the Hpyt molecules are adsorbed in an hexagonal arrangement with an average distance between the sulfur atoms of 5.5 Ã. These images also showed the presence of pinholes, which indicate that a strong lateral interaction does not effectively happen. The thermodynamics parameters ΔHads, ΔGads and ΔSads of the Hpyt and FeHpyt adsorption process were calculated from the correlation between the concentration of the adsorbates on the surface (Γ) and in solution (C) at different temperatures. The surface coverage data were obtained from the reductive desorption process RS-Au + e- �� RS- + AuÂ, where R = Hpyt or FeHpyt, observed at -555 and -566 mV vs Ag|AgCl|Cl- for Hpyt and FeHpyt SAM, respectively, indicating an enhancement of the AuâS bond as consequence of the π-backbonding interaction from iron metal center toward the Hpyt moiety. The heterogeneous electron transfer reaction of cytochrome c metalloprotein was successfully assessed by Hpyt and FeHpyt and SAM, presenting a quasi-reversible voltammograms with potentials consistent with the native form of the protein.
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6

Paulo, Tércio de Freitas. "5-(4-PIRIDIL)-1,3,4-(OXADIAZOL)-2-TIOL E Na3[Fe(CN)5Hpyt].3H2O: Síntese, caracterização e estudos de formação de monocamadas automontadas." reponame:Repositório Institucional da UFC, 2007. http://www.repositorio.ufc.br/handle/riufc/13715.

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PAULO, T. F.; DIÓGENES, I. C. N. 5-(4-PIRIDIL)-1,3,4-(OXADIAZOL)-2-TIOL E Na3[Fe(CN)5Hpyt].3H2O: Síntese, caracterização e estudos de formação de monocamadas automontadas. 2007. 85 f. Dissertação (Mestrado em Química Inorgânica) - Centro de Ciências, Universidade Federal do Ceará, Fortaleza, 2007.
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-(4-pyridinyl)-1,3,4-oxadiazole-2-thiol (Hpyt) and [Fe(CN)5Hpyt]3- (FeHpyt) species spontaneously adsorbed on gold forming SAM (Self-Assembled Monolayers) that, based on electrochemical data, contain pinholes through which [Fe(CN)6]4– and [Ru(NH3)6]3+ probe molecules access the underlying gold electrode. From the former molecule and the dependence of the faradaic current on the pH value of the electrolyte solution, the surface pKa of the Hpyt SAM was evaluated as 4.2. Taking into account the STM (Scanning tunneling Microscopy) results obtained for the Hpyt SAM on Au(111), it was possible to estimate that the Hpyt molecules are adsorbed in an hexagonal arrangement with an average distance between the sulfur atoms of 5.5 Å. These images also showed the presence of pinholes, which indicate that a strong lateral interaction does not effectively happen. The thermodynamics parameters ΔHads, ΔGads and ΔSads of the Hpyt and FeHpyt adsorption process were calculated from the correlation between the concentration of the adsorbates on the surface (Γ) and in solution (C) at different temperatures. The surface coverage data were obtained from the reductive desorption process RS-Au + e- �� RS- + Au°, where R = Hpyt or FeHpyt, observed at -555 and -566 mV vs Ag|AgCl|Cl- for Hpyt and FeHpyt SAM, respectively, indicating an enhancement of the Au–S bond as consequence of the π-backbonding interaction from iron metal center toward the Hpyt moiety. The heterogeneous electron transfer reaction of cytochrome c metalloprotein was successfully assessed by Hpyt and FeHpyt and SAM, presenting a quasi-reversible voltammograms with potentials consistent with the native form of the protein.
As espécies 5-(4-piridil)-1,3,4-oxadiazol-2-tiol (Hpyt) e [Fe(CN)5Hpyt]3- (FeHpyt) adsorvem espontaneamente sobre ouro formando monocamadas automontadas (SAM - "Self-Assembled Monolayers") das quais, de acordo com os dados eletroquímicos, apresentam defeitos ou nanoporos por onde as moléculas de prova [Fe(CN)6]4– e [Ru(NH3)6]3+ acessam a superfície do eletrodo de ouro policristalino. A partir dessas moléculas de prova e da dependência entre a corrente faradáica e o pH do eletrólito, o pKa da monocamada de Hpyt foi calculada como 4,2. A partir dos resultados de microscopia de tunelamento STM (Scanning Tunneling Microscopy) obtidos para a monocamada automontada de Hpyt sobre Au(111) foi possível estimar que as moléculas de Hpyt são adsorvidas em um arranjo hexagonal com um espaçamento médio entre os átomo de enxofre de 5,5 Å. Essas imagens também mostraram a presença de nanoporos, do qual indica que fortes interações laterais não ocorrem efetivamente. Os parâmetros termodinâmicos ΔHads, ΔGads e ΔSads para o processo de adsorção das moléculas Hpyt e FeHpyt foram calculados a partir da correlação entre a concentração dos adsorbatos na superfície (Γ) e em solução (C) para diferentes temperaturas. A quantidade de moléculas adsorvidas foi calculada a partir do processo de desorção redutiva, onde R = Hpyt ou FeHpyt, observados em -555 e -566 mV versus Ag|AgCl|Cl- para as monocamadas de Hpyt e FeHpyt, respectivamente, indicando um fortalecimento da ligação Au–S como conseqüência do efeito π-backbonding do centro metálico ferro para o ligante Hpyt. A reação heterogênea de transferência de elétrons da metaloproteína citocromo c foi satisfatoriamente acessada pelas monocamadas de Hpyt e FeHpyt, apresentando um voltamograma quasi-reversível com potenciais consistentes com a forma nativa desta proteína.
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7

Ko, Changheui. "Optimization of bulkheterojunction organic photovoltaics structure/property study with oxadiazole contained poly(p-phenylene)s [OXA-PPVs] and device system engineering /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 208 p, 2009. http://proquest.umi.com/pqdweb?did=1663060511&sid=4&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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8

Riederer, Cordula. "Zur Synthese von Tetrahydro-oxazolo[4,3-c]-1,2,4-oxadiazol-5-onen und Tetrahydro-oxazolo[4,3-c]-1,2,4-oxadiazin-6-onen aus 4-Hydroxyimino-oxazolidin-2-onen." [S.l. : s.n.], 1999. http://www.sub.uni-hamburg.de/disse/68/riederer.PDF.

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9

Almeida, Leonardo Viana de. "Síntese e determinação da atividade antimicrobiana de 2-[5-nitro-tiofen-2-il]-3-acetil-5-[4-fenil-substituído]-2,3-diidro-1,3,4-oxadiazol frente à cepa ATCC 25923 de Staphylococcus aureus." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/9/9135/tde-07042010-131506/.

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A introdução de um grupo substituinte na molécula de um fármaco promove alterações químico-estruturais que, por sua vez, modificam suas propriedades físicoquímicas. O arranjo espacial de átomos ou grupos de átomos, em especial grupos funcionais, na molécula de um fármaco, expressos por meio de suas propriedades físico-químicas, influenciam direta ou indiretamente na interação fármaco-receptor. Esta, por sua vez, determina aspectos farmacológicos e farmacocinéticos que influem na eficácia terapêutica do medicamento. Assim, uma série de compostos 2-[5-nitro-tiofen-2-il]-3-acetil-5-[4-fenil-substituído]-2,3-diidro-1,3,4-oxadiazolínicos foi planejada e os análogos foram sintetizados, identificados estruturalmente e avaliados in vitro quanto a atividade antimicrobiana frente a Staphylococcus aureus (cepa ATCC 25923), expressa pela determinação da concentração inibitória mínima. Cepas desta bactéria são comuns em infecções hospitalares e frequentemente apresentam caráter de multi-resistência, portanto, alternativas aos fármacos comumente empregados na terapia antibacteriana, especialmente em infecções multi-resitentes, são alvo de estudos e desenvolvimento. Relações entre mudanças estruturais de 2-[5-nitro-tiofen-2-il]-3-acetil-5-[4- fenil-substituído]-2,3-diidro-1,3,4-oxadiazolinas e suas respectivas concentrações inibitórias mínimas podem fornecer informações sobre a influência de propriedades físico-químicas na ação antibacteriana destes compostos, informações estas que podem contribuir para o entendimento das relações entre a estrutura química e a atividade biológica desta classe de compostos, visando a identificação qualitativa e quantitativa das propriedades físico-químicas que influenciam no perfil farmacológico desta classe de compostos. Os grupos substituintes introduzidos nos derivados de 2,3-diidro-1,3,4-oxadizolinas-2,3,5-substituídas contribuem para alterações em suas propriedades físico-químicas, sendo representadas por parâmetros físico-químicos que descrevem a natureza e intensidade da alteração observada. O presente trabalho objetivou identificar, partindo das propriedades físico-químicas, fatores da estrutura química que favoreçam a atividade antimicrobiana dos compostos estudados. A atividade antimicrobiana, expressa pela concentração inibitória mínima, foi determinada pelo procedimento de microdiluição sucessiva, no qual diferentes concentrações de composto a ser analisado foram incubadas em presença de inóculo de Staphylococcus aureus, em meio de cultura líquido. As microdiluições originam concentrações decrescentes a fim de se determinar a menor concentração do composto testado onde o crescimento microbiano foi inibido. Foram realizadas comparações entre as concentrações inibitórias mínimas dos compostos analisados e destas com parâmetros estruturais que representam as propriedades físico-químicas dos compostos. Baseado nas análises comparativas, identificou-se tendências que evidenciam a preponderância de propriedades físicoquímicas sobre a atividade antimicrobiana desempenhada. Constatou-se que a hidrofobicidade influi significativamente na atividade antimicrobiana. Observou-se também que o efeito eletrônico por indução e o volume do grupo substituinte em posição para-fenila também influenciam a ação antimicrobiana, mas estas ainda não foram conclusivas, carecendo de estudos mais aprofundados que levem à compreensão dos fatores estruturais que mais influenciam a ação antimicrobiana de 2-[5-nitro-tiofen-2-il]-3-acetil-5-[4-fenilsubstituído]- 2,3-diidro-1,3,4-oxadiazolinas, de forma a fundamentar o planejamento de futuros candidatos a fármacos antimicrobianos a partir desta classe de compostos.
The introduction of a substitute group within a drug molecule promotes chemical-structure shifts, which by consequence, alters its physical-chemical properties. The atomic special design, particularly the one related to functional groups, assumed in a drug molecule, expressed by the physical-chemical properties, interferers directly or indirectly on drug-receptor interaction. Theses effects collaborate to pharmacologic and pharmacokinetics aspects of drugs, interfering with its therapeutic efficient. Therefore, a set of 2-[5-nitro-thiophen-2-yl]-3-acetyl-5-[4- substitued-phenyl]-3,4-dihydro-1,3,4-oxadiazolines compounds was designed and its analogs synthesized, structurally identified, and in vitro assayed due to its antimicrobial activity against ATCC 25923 Staphylococcus aureus strains, through the determination of minimum inhibitory concentration. Strains of such bacterial species are commonly present within hospital infections, and frequently appear as multi-resistant variant. Consequently, alternatives to the agents usually applied in antimicrobial chemotherapy, particularly to multi-resistant infections, are target for drug research and development. Relations among structural shifts on 2-[5-nitro-thiophen-2-yl]-3-acetyl-5-[4-substitued-phenyl]-3,4-dihydro-1,3,4-oxadiazolines compounds and its respective minimum inhibitory concentration may lead to information about the influence of physical-chemical properties in antimicrobial activity. Continually, such information might contribute to the elucidation of chemical structure-biological activity relationship of these compounds. The substitutes groups inserted on 2,3,5-substituted-3,4-dihydro-1,3,4-oxadiazolines derivates contribute to differs the molecule physical-chemical properties, which is represented by its physical-chemical parameters, which describe the nature and intensity of the observed modification. Therefore, the following study aimed to identify, throughout physical-chemical properties, chemical structure factors that favor the antimicrobial activity of the synthesized compounds. The antibacterial activity, expressed as the minimum inhibitory concentration, was quantified by the microdilution method, where gradual concentrations of the tested conpound were incubated within ATCC 25923 Staphylococcus aureus cells suspended in broth medium. The microdilutions originated descending concentrations, in order to spot the minimum concentration whose microbial growth was inhibited. The minimum inhibitory concentration regarded to each compound was correlated to its physical-chemical parameters. Based on observed relations, it could be identified evidences assuming the physical-chemical properties relevance on antimicrobial assay. It was verified that hydrophobic effects interferes with antimicrobial activity, as well as inductive electronic effects and molecular volume of substitute group in para-phenyl position. These factors contribute to physical-chemical properties shifts and therefore play a role on the antimicrobial action. However, these latest two influences were enable to conclude, suggesting the need of more extensive studies. So that, a more profound comprehension about structure factors that interfere with 2,3,5-substitued-3,4-dihydro-1,3,4-oxadiazolines derivates might lead to the rational design of potential antimicrobial agents among this class of compounds.
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Oliveira, Alex Alfredo de. "Planejamento, síntese, determinação da atividade biológica e estudos de QSAR-2D de derivados 1,3,4-oxadiazolínicos frente ao Trypanosoma cruzi." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/9/9135/tde-22122011-084355/.

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Doenças como malária, esquistossomose, filaríase linfática, dengue, leishmaniose e mal de Chagas são endêmicas em países tropicais. Referente ao período entre 1975 e 2004, apenas 1% dos 1.556 novos fármacos registrados foi destinado ao tratamento destas doenças. Somente a doença de Chagas possui aproximadamente 18 milhões de casos em todo mundo. Até o momento, a quimioterapia para o tratamento dessa antropozoonose constitui-se basicamente de dois fármacos, o nifurtimox, proscrito no Brasil, e o benznidazol. Estes fármacos, além de apresentarem vários efeitos colaterais, são pouco eficazes, o que dificulta a adesão dos pacientes ao tratamento. Diante da necessidade imediata de novos fármacos para o combate de tripanossomíase americana, estratégias de modificação molecular têm se mostrado como ferramenta promissora para obtenção de novos fármacos, geralmente inspirados na estrutura molecular de fármacos já conhecidos. A estratégia de modificação molecular permite aumentar as chances de sucesso no processo de descoberta de novos fármacos, reduzindo tempo e custo da pesquisa. Este trabalho teve como objetivo o planejamento, a síntese e a avaliação da atividade anti-T. cruzi e a identificação das propriedades físico-químicas que são responsáveis por modular a atividade anti-T. cruzi da série dos 2-[5-nitrotiofeno- 2-il]-3-acetil-5-[4-fenil-substituído]-2,3-diidro-1,3,4-oxadiazolinas, compostos com estrutura análoga à nifuroxazida, fármaco antimicrobiano que também apresenta atividade antiparasitária. O planejamento da série de compostos estudados foi realizado com base no diagrama de Craig. A obtenção dos derivados 1,3,4-oxadiazolínicos foi realizada em quatro etapas sintéticas: esterificação, amonólise, obtenção da base de Schiff e ciclização oxidativa. As estruturas planejadas foram confirmadas por RMN 1H e RMN 13C, enquanto a pureza foi avaliada pela faixa de fusão e de análise elementar de CHN. A atividade antiparasitária dos compostos foi determinada frente à cepa Y da forma epimastigota do T. cruzi e a concentração de parasitas foi quantificada através da absorbância em espectrofotômetro UV/Vis (λ = 580 nm). Os quinze compostos da série foram avaliados em 6 diferentes concentrações (3,75; 5; 7,5 ; 10; 15; 20 µM), sendo que somente o etoxi-derivado não foi mais ativo que o fármaco padrão, o benznidazol. Entre os compostos analisados identificaram-se o mais e o menos ativo da série, respectivamente: o 2-[5-nitro-tiofeno-2-il]-3-acetil-5-[4 fenil-acetoxi]-2,3-diidro-1,3,4-oxadiazolinas (IC50=7,91 µM) e o 2-[5-nitrotiofeno-2-il]-3-acetil-5-[4 fenil-etoxi]-2,3-diidro-1,3,4-oxadiazolinas ((IC50=26,60 µM). Através de estudos de QSAR-2D, a atividade anti-T. cruzi foi correlacionada com descritores físico-químicos, como a hidrofobicidade, os efeitos eletrônicos e o volume molecular. Com a aplicação de modelos matemáticos, ficou evidenciado que a atividade anti-T. cruzi desta série de compostos sofre notável influência da hidrofobicidade e dos efeitos eletrônico de ressonância, o que permite a continuidade deste trabalho através da variação planejada destas propriedades, visando identificar o análogo mais potente da série de compostos estudados.
Diseases like malaria, schistosomiasis, lymphatic filariasis, dengue, leishmaniasis and Chagas\'disease are endemic in tropical countries. From 1975 to 2004, only 1% of 1.556 new drugs were registered for the treatment of these diseases. Chagas disease itself has approximately 18 million of cases worldwide, and the chemotherapy for the treatment of this anthropozoonosis consists basically of two drugs, nifurtimox, which is prohibited in Brazil, and benznidazole. These drugs have various side effects and can also be ineffective, making patients give up the treatment. Given the immediate need for new drugs to treat american trypanosomiasis, molecular modification strategies have been shown as a promising tool for obtaining new drugs, often inspired by the molecular structure of known drugs. The strategy of molecular modification will increase the chances of success in the discovery process of new drugs, reducing the time and the costs of research. Given the situation above described, this work aims to design synthesis and evaluate the anti-Trypanosoma cruzi activity of new drugs as well as identification physicochemical properties that are responsible for modulating the anti-T. cruzi activity. Series of 2-[5-nitro-thiofen-2-yl]-3-acetyl-5-[4-phenyl-substituted]-2,3-dihydro-1,3,4-oxadiazolines, compounds with similar structure to nifuroxazide, an antimicrobial drug that also has antiparasitic activity. The planning of the series of compounds was carried out based on the Craig diagram. The obtainment of the1,3,4-oxadiazolinics derivatives was performed with four synthetic steps, as follows: esterification, ammonolysis, obtention of the Schiff base and oxidative cyclization. The designed structures were confirmed by 1H and 13C NMR and purity was assessed by melting point and elemental analysis of CHN. The antiparasitic activity of compounds was determined against the Y strain of T. cruzi in the epimastigote form and the concentration of parasites was quantified by absorbance in a spectrophotometer UV / Vis (λ = 580 nm). The fifteen compounds obtained were evaluated in six different concentrations (3.75, 5, 7.5, 10, 15, 20 µM), and only the ethoxy-derivative was less active than the standard drug, benznidazole. The 2-[5-nitrothiofen- 2-yl]-3-acetyl-5-[4-acetoxyphenyl]-2,3-dihydro-1,3,4-oxadiazolines (IC50=7.91µM) and of 2-[5-nitro-thiofen-2-yl]-3-acetyl-5-[4-etoxyphenyl]-2,3-dihydro-1,3,4-oxadiazolines (IC50=26.60 µM) derivatives were identified as the most and the least active of the series, respectively. Through 2D-QSAR studies, the anti-T. cruzi activity was correlated with physicochemical descriptors such as hydrophobicity, molecular volume and electronic effects. Applying mathematical models, it became evident that the activity of anti-T. cruzi activity in this series of compounds undergoes remarkable influence of hydrophobicity and electronic effects of resonance, which allows the continuity of the work planned by varying these properties to identify the most potent analogue among the series of compounds studied.
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Books on the topic "4-oxadiazole"

1

Bradley, Jean-Claude. A study of the reactivity of the carboxyl function in 1, 3, 4-oxadiazole-2-carboxylates. Sudbury, Ont: Laurentian University, 1989.

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Rakaric, Peter. Oligo - 1, 3, 4 - oxadiazoles. Sudbury, Ont: Laurentian University, 1998.

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Tremblay, Rose-Marie. Synthesis of 5-methyl-1, 3, 4-oxadiazol-2-carboxylate esters. Sudbury, Ont: Laurentian University, 1994.

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Book chapters on the topic "4-oxadiazole"

1

Pardasani, R. T., and P. Pardasani. "Magnetic properties of manganese(II) complex with 5-(4-methoxy-phenyl)-1,3,4-oxadiazole-2-thione containing ethylenediamine." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 6, 176–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-65056-1_65.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of manganese(II) complex with 5-(4-pyridyl)-1,3,4-oxadiazole-2-thione containing 2,2′-bipyridine." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 6, 182–84. Berlin, Heidelberg: Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-65056-1_67.

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Ambhore, Ajay N. "An Efficient Green Synthesis of Diphenyl Pyrazol-4-Yl-Thiopyridin-4-Yl-1,3,4-Oxadiazole Derivatives and Evaluation of Their Antimicrobial and Antioxidant Activity." In Modern Green Chemistry and Heterocyclic Compounds, 79–111. Series statement: Innovations in physical chemistry: monographic series: Apple Academic Press, 2020. http://dx.doi.org/10.1201/9780367276942-3.

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Khalid, Hira, Aziz-ur-Rehman, M. Athar Abbasi, Rashad Hussain, Abdul Malik, Muhammad Ashraf, and M. Qaiser Fatmi. "Synthesis, Spectral Analysis and Biological Evaluation of 5-Substituted 1,3,4-Oxadiazole-2-yl-4-(Piperidin-1-ylsulfonyl)Benzyl Sulfide." In Emerging Trends in Chemical Sciences, 221–38. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60408-4_14.

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Revanasiddappa, B. C., and E. V. S. Subrahmanyam. "Study on 1, 3, 4-Oxadiazole Derivatives as an Antibacterial and Antifungal Agents." In New Innovations in Chemistry and Biochemistry Vol. 2, 124–29. Book Publisher International (a part of SCIENCEDOMAIN International), 2021. http://dx.doi.org/10.9734/bpi/nicb/v2/13095d.

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Rajendran, Pavitra, and Erumaipatty Rajagounder Nagarajan. "Fluorescent Polyimide in Sensing Applications." In Polyimides. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.99935.

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Potential advances in sensing can be made by conjugated polymers includes poly(p-phenylene), poly(p-phenylene vinylene), polyfluorene, and poly(thiophene). Among the most important classes of polymers are heterocyclic polymers, such as polyimides, because polyimide nanocomposites possess exceptional mechanical strength as well as chemical, mechanical and temperature resistance. Polyimide offers the potential of providing efficient sensors through its ability to work actively. There is evidence that fluorescent polyimide is efficient at detecting hazardous pollutants. Chemical modifications of the polyimide backbone gave rise to an improved luminescence efficiency of polyimide by incorporating fluorescent chromophores. An overview of recent developments in fluorescent polyimide in sensing applications is presented in this chapter. Some of the fluorescent polyimide materials prepared from different types with surface modification (type-1: perylene tetracarboxylic dianhydride and oxydianiline) (type-2: Tetra (4-aminophenyl) porphyrin and perylenetracarboxylic dianhydride) and (type-3 2-(4,4′-diamino-4′′-triphenylamine)-5-(4-dimethylaminophenyl)-1,3,4-oxadiazole) etc. In the following section, the methods and sensing mechanism of fluorescent polyimide are described.
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Conference papers on the topic "4-oxadiazole"

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Tyrkov, Alexey, Svetlana Luzhnova, Evgenia Utyaganova, and Ekaterina Yurtayeva. "Promising materials based on Tetrahydro-[1,2,4]Oxadiazole[3,2-C][1,4]Oxazine for innovative biotechnologies." In "The Caspian in the Digital Age" within the framework of the International Scientific Forum "Caspian 2021: Ways of Sustainable Development". Dela Press Publishing House, 2022. http://dx.doi.org/10.56199/dpcsebm.sddh5085.

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The synthesis of 2-[(1,3-diphenyl-1H-1,2,4-triazol-5-yl) dinitromethyl]-5,6,8,8a-tetrahydro-[1,2,4] oxadiazol[3,2-c][1,4] oxazine is caused by the reaction of morpholine interaction in the presence of hydrogen peroxide with 2-(1,3-diphenyl-1H-1,2,4-triazol-5-yl)-2,2-dinitroacetonitrile and sodium tungstate in a catalytic amount. The latter interacts with an excess of KOH in ethanol to form the potassium salt aci-5-dinitromethyl-1,3-diphenyl-1H-1,2,4-triazole and 5,6,8,8a-tetrahydro-[1,2,4] oxadiazole[3,2-c] [1,4] oxazine-2-ol. The ability of compounds 3-5 to inhibit the growth and development of museum strains of Staphylococcus aureus RP, E. coli O39, Pseudomonas aeruginosa 143 and clinical strain of Streptococcus pneumonia, as well as clinically significant species of fungi Trichophyton rubrum, Microsporumcanis and Candida albicans was investigated. It was revealed that the compounds have bacteriostatic activity against the studied bacterial strains: 3 and 4 expressed in a range of low concentrations. Compounds 3-5 demonstrate a fungistatic effect: compound 3 in a range of low concentrations. In relation to fungal strains, compounds 3-5 demonstrate a fungistatic effect: compound 3 in the range of low concentrations. Thus, as a result of the implementation of the "one pot" process, it is possible to embed oxadiazoline and oxazine cycles into the main (central) part of the compound 1 molecule, which leads to the synthesis of new drugs with antimicrobial and antifungal activity.
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Troitskaya-Markova, Nadezhda, Olga Vlasova, and Oleg Rakitin. "4,5-DIOXO-4,5-DIHYDRO-4Λ4,5Λ4-BIS([1,2,5]OXADIAZOLO)[3,4-с:3',4'-e]PYRIDAZINE AS A SYNTHETIC EQUIVALENT OF 4,4'-DINITROSO-3,3'-BI(1,2,5-OXADIAZOLE)." In Chemistry of nitro compounds and related nitrogen-oxygen systems. LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m779.aks-2019/305-307.

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Zhang, Wei, Junsheng Yu, Nana Wang, Chunhua Huang, and Yadong Jiang. "Efficient organic photovoltaic cells using 2-(4-biphenylyl)-5-phenyl-1,3,4-oxadiazole as an exciton blocking layer." In 5th International Symposium on Advanced Optical Manufacturing and Testing Technologies, edited by Ya-Dong Jiang, Bernard Kippelen, and Junsheng Yu. SPIE, 2010. http://dx.doi.org/10.1117/12.866815.

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Varvara, Simona, Gianina Damian, Camelia Berghian-Grosan, Maria Popa, and Florin Popa. "Corrosion inhibition of carbon steel in hydrochloric acid solution using 5-(4-Pyridyl)-1,3,4-oxadiazole-2-thiol." In 1st Corrosion and Materials Degradation Web Conference. Basel, Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/cmdwc2021-10005.

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Abood, Zeid Hassan, Hayder Raheem Ali, and Hussein Ali Qabel. "Microwave synthesis of 2,3,5-trisubstituted-1,3-imidazolidin-4-ones bearing 1,3,4-oxadiazole moiety and preliminary evaluation of their antibacterial activity." In THE 7TH INTERNATIONAL CONFERENCE ON APPLIED SCIENCE AND TECHNOLOGY (ICAST 2019). AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5123064.

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Sushma and S. Ananda. "Synthesis of hybrid nano CoO/2-(4-chlorophenyl)-5-(3,4-dimethoxyphenyl)-1,3,4-Oxadiazole: Characterization and its application for viscosity studies for lubrication and photo-degradation." In DAE SOLID STATE PHYSICS SYMPOSIUM 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0017530.

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saki, zeinab, Ali Kakanejadifard, Abedin Zabardasti, Farideh Azarbani, and Sahar Kakanejadifard. "Synthesis, characterization, solvatochromic, antioxidant and antibacterial activities investigation of 2,2'-((1E,1'E)-((1,2,5-oxadiazole-3,4-diyl)bis (azanylylidene))bis(methanylylidene))bis(4-(phenyldiazenyl)phenol)." In The 20th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2016. http://dx.doi.org/10.3390/ecsoc-20-a047.

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Saleh, R. A., H. A. Mohammad, T. I. Gerber, and E. C. Hosten. "Synthesis and characterization of mono and mixed ligand, Ni(II), Pd(II) and Pt(II) complexes of S-5-phenyl-1, 3, 4-oxadiazole-2-yl benzothioate with some tertiary diphosphines ligands." In 6TH INTERNATIONAL CONFERENCE AND WORKSHOPS ON BASIC AND APPLIED SCIENCES. Author(s), 2017. http://dx.doi.org/10.1063/1.5004324.

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Forostyanko, Anna, Elena Vasileva, and Irina Proskurina. "SYNTHESIS OF 5-(4’-NITROPHENYL)-3-ARYL-1,2,4-OXADIAZOLES." In Chemistry of nitro compounds and related nitrogen-oxygen systems. LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m758.aks-2019/222-226.

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Stadlbauer, Wolfgang, Corinna Gressl, A. Elisabeth Täubl, and Werner Fiala. "Cyclization of 4-Azido-3-nitroquinolines to Oxadiazolo[3,4-c]quinolines." In The 14th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2010. http://dx.doi.org/10.3390/ecsoc-14-00487.

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Reports on the topic "4-oxadiazole"

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Byrd, Edward F., and Jesse J. Sabatini. Theoretical Prediction of the Heats of Formation, Densities and Relative Sensitivities, and/or Synthetic Approaches Toward the Synthesis of High Energy Dense Materials (HEDMs): 3,5-Dinitro-1,3,5-Oxadiazinane, Bis-Adjacent RDX, Bis-Adjacent HMX, 4,4',6,6'-Tetranitro-1,1'-Bis(N-oxide)-5,5',6,6'-4H,4'H-5,5'-Bisimidazo Oxadiazole, and the Open-Cage Derivative of CL-20. Fort Belvoir, VA: Defense Technical Information Center, August 2015. http://dx.doi.org/10.21236/ada626921.

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