Relevant bibliographies by topics / 4-HPPD

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic '4-HPPD'

Author: Grafiati
Published: 4 June 2021
Last updated: 10 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic '4-HPPD.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "4-HPPD"

1

Lin, Hong-Yan, Xi Chen, Jia-Nan Chen, Da-Wei Wang, Feng-Xu Wu, Song-Yun Lin, Chang-Guo Zhan, Jia-Wei Wu, Wen-Chao Yang, and Guang-Fu Yang. "Crystal Structure of 4-Hydroxyphenylpyruvate Dioxygenase in Complex with Substrate Reveals a New Starting Point for Herbicide Discovery." Research 2019 (July 8, 2019): 1–11. http://dx.doi.org/10.34133/2019/2602414.

Full text
Abstract:
4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a promising target for drug and pesticide discovery. The unknown binding mode of substrate is still a big challenge for the understanding of enzymatic reaction mechanism and novel HPPD inhibitor design. Herein, we determined the first crystal structure of Arabidopsis thaliana HPPD (AtHPPD) in complex with its natural substrate (HPPA) at a resolution of 2.80 Å. Then, combination of hybrid quantum mechanics/molecular mechanics (QM/MM) calculations confirmed that HPPA takes keto rather than enol form inside the HPPD active pocket. Subsequent site-directed mutagenesis and kinetic analysis further showed that residues (Phe424, Asn423, Glu394, Gln307, Asn282, and Ser267) played important roles in substrate binding and catalytic cycle. Structural comparison between HPPA-AtHPPD and holo-AtHPPD revealed that Gln293 underwent a remarkable rotation upon the HPPA binding and formed H-bond network of Ser267-Asn282-Gln307-Gln293, resulting in the transformation of HPPD from an inactive state to active state. Finally, taking the conformation change of Gln293 as a target, we proposed a new strategy of blocking the transformation of HPPD from inactive state to active state to design a novel inhibitor with Ki value of 24.10 nM towards AtHPPD. The inhibitor has entered into industry development as the first selective herbicide used for the weed control in sorghum field. The crystal structure of AtHPPD in complex with the inhibitor (2.40 Å) confirmed the rationality of the design strategy. We believe that the present work provides a new starting point for the understanding of enzymatic reaction mechanism and the design of next generation HPPD inhibitors.
APA, Harvard, Vancouver, ISO, and other styles
2

Huang, Chih-Wei, Chi-Ching Hwang, Yung-Lung Chang, Jen-Tzu Liu, Sheng-Peng Wu, Kai-Ling Huang, Wei-min Huang, and Hwei-Jen Lee. "Functional role of residues involved in substrate binding of human 4-hydroxyphenylpyruvate dioxygenase." Biochemical Journal 478, no. 12 (June 18, 2021): 2201–15. http://dx.doi.org/10.1042/bcj20210005.

Full text
Abstract:
4-Hydroxylphenylpyruvate dioxygenase (HPPD) catalyzes the conversion of 4-hydroxylphenylpyruvate (HPP) to homogentisate, the important step for tyrosine catabolism. Comparison of the structure of human HPPD with the substrate-bound structure of A. thaliana HPPD revealed notably different orientations of the C-terminal helix. This helix performed as a closed conformation in human enzyme. Simulation revealed a different substrate-binding mode in which the carboxyl group of HPP interacted by a H-bond network formed by Gln334, Glu349 (the metal-binding ligand), and Asn363 (in the C-terminal helix). The 4-hydroxyl group of HPP interacted with Gln251 and Gln265. The relative activity and substrate-binding affinity were preserved for the Q334A mutant, implying the alternative role of Asn363 for HPP binding and catalysis. The reduction in kcat/Km of the Asn363 mutants confirmed the critical role in catalysis. Compared to the N363A mutant, the dramatic reduction in the Kd and thermal stability of the N363D mutant implies the side-chain effect in the hinge region rotation of the C-terminal helix. The activity and binding affinity were not recovered by double mutation; however, the 4-hydroxyphenylacetate intermediate formation by the uncoupled reaction of Q334N/N363Q and Q334A/N363D mutants indicated the importance of the H-bond network in the electrophilic reaction. These results highlight the functional role of the H-bond network in a closed conformation of the C-terminal helix to stabilize the bound substrate. The extremely low activity and reduction in Q251E's Kd suggest that interaction coupled with the H-bond network is crucial to locate the substrate for nucleophilic reaction.
APA, Harvard, Vancouver, ISO, and other styles
3

Liu, Yong-Xuan, Shuang Gao, Tong Ye, Jia-Zhong Li, Fei Ye, and Ying Fu. "Combined 3D-quantitative structure–activity relationships and topomer technology-based molecular design of human 4-hydroxyphenylpyruvate dioxygenase inhibitors." Future Medicinal Chemistry 12, no. 9 (May 2020): 795–811. http://dx.doi.org/10.4155/fmc-2019-0349.

Full text
Abstract:
Aim: 4-Hydroxyphenylpyruvate dioxygenase (HPPD) has attracted increasing attention as an important target against tyrosinemia type I. This paper aimed to explore the structure–activity relationship of HPPD inhibitors with pyrazole scaffolds and to design novel HPPD inhibitors. Methodology & results: The best 3D-quantitative structure–activity relationships model was established by two different strategies based on 40 pyrazole scaffold-based analogs. Screening of molecular fragments by topomer technology, combined with molecular docking, 14 structures were identified for potential human HPPD inhibitory activity. Molecular dynamics results demonstrated that all the compounds obtained bound to the enzyme and possessed a satisfactory binding free energy. Conclusion: The quantitative structure–activity relationship of HPPD inhibitors of pyrazole scaffolds was clarified and 14 original structures with potential human HPPD inhibitory activity were obtained.
APA, Harvard, Vancouver, ISO, and other styles
4

Oliveira, Maxwel C., Amit J. Jhala, Todd Gaines, Suat Irmak, Keenan Amundsen, Jon E. Scott, and Stevan Z. Knezevic. "Confirmation and Control of HPPD-Inhibiting Herbicide–Resistant Waterhemp (Amaranthus tuberculatus) in Nebraska." Weed Technology 31, no. 1 (January 2017): 67–79. http://dx.doi.org/10.1017/wet.2016.4.

Full text
Abstract:
Field and greenhouse experiments were conducted in Nebraska to (1) confirm the 4-hydroxyphenylpyruvate dioxygenase (HPPD)-inhibiting resistant-waterhemp biotype (HPPD-RW) by quantifying the resistance levels in dose-response studies, and (2) to evaluate efficacy of PRE-only, POST-only, and PRE followed by POST herbicide programs for control of HPPD-RW in corn. Greenhouse dose-response studies confirmed that the suspected waterhemp biotype in Nebraska has evolved resistance to HPPD-inhibiting herbicides with a 2- to 18-fold resistance depending upon the type of HPPD-inhibiting herbicide being sprayed. Under field conditions, at 56 d after treatment, ≥90% control of the HPPD-RW was achieved with PRE-applied mesotrione/atrazine/S-metolachlor+acetochlor, pyroxasulfone (180 and 270 g ai ha−1), pyroxasulfone/fluthiacet-methyl/atrazine, and pyroxasulfone+saflufenacil+atrazine. Among POST-only herbicide programs, glyphosate, a premix of mesotrione/atrazine tank-mixed with diflufenzopyr/dicamba, or metribuzin, or glufosinate provided ≥92% HPPD-RW control. Herbicide combinations of different effective sites of action in mixtures provided ≥86% HPPD-RW control in PRE followed by POST herbicide programs. It is concluded that the suspected waterhemp biotype is resistant to HPPD-inhibiting herbicides and alternative herbicide programs are available for effective control in corn. The occurrence of HPPD-RW in Nebraska is significant because it limits the effectiveness of HPPD-inhibiting herbicides.
APA, Harvard, Vancouver, ISO, and other styles
5

Kosař, Michal, Lumila Holková, Natálie Březinová Belcredi, and Jaroslava Ehrenbergerová. "HPPD gene expression in relation to vitamin E content in spring barley." Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis 57, no. 4 (2009): 13–18. http://dx.doi.org/10.11118/actaun200957040013.

Full text
Abstract:
The enzyme 4-hydroxyphenylpyruvate dioxygenase (HPPD) has a very important role in the biosynthetic pathway of vitamin E. Its activity influences the final level of tocols in plant tissues. Seven barley cultivars with different vitamin E level were grown under control conditions and activity of HPPD gene was measured four, eight and twelve days after pollination of ear tissues. It was found that activity of HPPD gene corresponded with vitamin E content detected in grains (r = 0.77*). The relationship between the gene activity for HPPD eight and twelve days after pollination and vitamin E content was also confirmed for analyzed cultivars grown in the field conditions (r = 0.85*).
APA, Harvard, Vancouver, ISO, and other styles
6

Fu, Ying, Tong Ye, Yong-Xuan Liu, Jian Wang, and Fei Ye. "Based on the Virtual Screening of Multiple Pharmacophores, Docking and Molecular Dynamics Simulation Approaches toward the Discovery of Novel HPPD Inhibitors." International Journal of Molecular Sciences 21, no. 15 (August 3, 2020): 5546. http://dx.doi.org/10.3390/ijms21155546.

Full text
Abstract:
4-Hydroxyphenylpyruvate dioxygenase (HPPD) is an iron-dependent non-heme oxygenase involved in the catabolic pathway of tyrosine, which is an important enzyme in the transformation of 4-hydroxyphenylpyruvic acid to homogentisic acid, and thus being considered as herbicide target. Within this study, a set of multiple structure-based pharmacophore models for HPPD inhibitors were developed. The ZINC and natural product database were virtually screened, and 29 compounds were obtained. The binding mode of HPPD and its inhibitors obtained through molecular docking study showed that the residues of Phe424, Phe381, His308, His226, Gln307 and Glu394 were crucial for activity. Molecular-mechanics-generalized born surface area (MM/GBSA) results showed that the coulomb force, lipophilic and van der Waals (vdW) interactions made major contributions to the binding affinity. These efforts will greatly contribute to design novel and effective HPPD inhibitory herbicides.
APA, Harvard, Vancouver, ISO, and other styles
7

Wang, Man-Man, Hao Huang, Lei Shu, Jian-Min Liu, Jian-Qiu Zhang, Yi-Le Yan, and Da-Yong Zhang. "Synthesis and herbicidal activities of aryloxyacetic acid derivatives as HPPD inhibitors." Beilstein Journal of Organic Chemistry 16 (February 19, 2020): 233–47. http://dx.doi.org/10.3762/bjoc.16.25.

Full text
Abstract:
A series of aryloxyacetic acid derivatives were designed and synthesized as 4-hydoxyphenylpyruvate dioxygenase (HPPD) inhibitors. Preliminary bioassay results reveal that these derivatives are promising Arabidopsis thaliana HPPD (AtHPPD) inhibitors, in particular compounds I12 (K i = 0.011 µM) and I23 (K i = 0.012 µM), which exhibit similar activities to that of mesotrione, a commercial HPPD herbicide (K i = 0.013 µM). Furthermore, the newly synthesized compounds show significant greenhouse herbicidal activities against tested weeds at dosages of 150 g ai/ha. In particular, II4 exhibited high herbicidal activity for pre-emergence treatment that was slightly better than that of mesotrione. In addition, compound II4 was safe for weed control in maize fields at a rate of 150 g ai/ha, and was identified as the most potent candidate for a novel HPPD inhibitor herbicide. The compounds described herein may provide useful guidance for the design of new HPPD inhibiting herbicides and their modification.
APA, Harvard, Vancouver, ISO, and other styles
8

O’Brien, Sarah R., Adam S. Davis, and Dean E. Riechers. "Quantifying Resistance to Isoxaflutole and Mesotrione and Investigating Their Interactions with Metribuzin POST in Waterhemp (Amaranthus tuberculatus)." Weed Science 66, no. 5 (September 2018): 586–94. http://dx.doi.org/10.1017/wsc.2018.36.

Full text
Abstract:
AbstractGreenhouse experiments were conducted to quantify resistance levels to the 4-hydroxyphenyl-pyruvate dioxygenase (HPPD)-inhibiting herbicides mesotrione (MES) and isoxaflutole (IFT) in NEB (Nebraska HPPD- and atrazine-resistant) and SIR (Stanford, IL, HPPD- and atrazine-resistant) waterhemp [Amaranthus tuberculatus(Moq.) J. D. Sauer] populations. These populations differ in their field-use histories and resistance levels to MES. Foliar growth responses were compared with ACR (HPPD sensitive; metabolic atrazine-resistant) and SEN (sensitive to HPPD and photosystem II [PSII] inhibitors). A greenhouse dose–response study was conducted with each herbicide at two POST timings: early (EPOST) (5 cm; 4 to 5 true leaves) and POST (10 cm; 8 to 9 true leaves). At the EPOST timing, SIR was 10-fold resistant to IFT and 32-fold resistant to MES, while NEB was 4-fold resistant to IFT and 7-fold resistant to MES when compared with ACR. At the POST timing, SIR was 17-fold resistant to IFT and 21-fold resistant to MES, while NEB was 3-fold resistant to IFT and 7-fold resistant to MES when compared with ACR. Results overall indicated greater fold-resistance levels to MES relative to IFT at each timing. However, POST treatments to SIR showed contrasting effects on resistance levels relative to EPOST. To investigate potential management strategies for resistantA. tuberculatuspopulations, a POST interaction study was conducted using combinations of metribuzin and either IFT or MES. A metribuzin rate (191 g ai ha−1) causing an approximately 20% biomass reduction was chosen for interaction studies and combined with varying rates of either IFT or MES. Results indicated 52.5 g ai ha−1of MES combined with metribuzin displayed a synergistic effect on biomass reduction in SIR. However, other combinations of either MES or IFT and metribuzin resulted in additive effects on biomass reduction in both HPPD-resistant populations. These results provide insights into the joint activity between HPPD and PSII inhibitors for controlling metabolism-based, multiple herbicide–resistantA. tuberculatus.
APA, Harvard, Vancouver, ISO, and other styles
9

Chen, Jinsong, Lin Zhang, and Junwu Zhang. "Chondrocyte proliferation is promoted by 7-H-pyrrolo[2,3- d]pyrimidine via up-regulation of type II collagen matrix." Tropical Journal of Pharmaceutical Research 19, no. 4 (May 14, 2020): 683–89. http://dx.doi.org/10.4314/tjpr.v19i4.2.

Full text
Abstract:
Purpose: To investigate the effect of 7-H-pyrrolo[2,3-d]pyrimidine derivative (7-HPPD) on the viability of chondrocytes in vitro, and to elucidate the associated mechanisms.Methods: Chondrocyte proliferation was determined by 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay while cell cycle was assessed by flow cytometry. Western blot and immunohistochemical staining assays were used to determine protein levels.Results: The results show that 7-HPPD significantly increased the proliferation rate of chondrocytes in a concentration-dependent manner (p < 0.05). The proportion of chondrocytes in S phase increased significantly with subsequent reduction in G0/G1 phase of cell cycle on treatment with 7-HPPD (p <0.05). Thus, 7-HPPD increased the rate of chondrocyte proliferation by promoting transition through G1/S phase of cell cycle. Reverse transcription polymerase chain reaction (RT-PCR) and western blot analysis revealed that treatment of chondrocytes with 7-HPPD caused a marked increase in the level of cyclin D1, cyclin dependent kinase (CDK)-4 and CDK6 proteins (p < 0.05). Western blot and immunohistochemical staining assays showed that 7-HPPD treatment caused a significant increase in the levels of type II collagen matrix in the chondrocytes.Conclusion: Proliferation of chondrocytes is increased by 7-HPPD and this occurs by facilitating G1/S phase transition and increasing expression of cyclin D1, CDK4 and CDK6 proteins. Therefore, 7-HPPD may be developed as a chemotherapeutic agent for the treatment of osteoarthritis. Keywords: Immunohistochemistry, Type II collagen, G1/S phase, Cyclin D1, Osteoarthritis
APA, Harvard, Vancouver, ISO, and other styles
10

Evans, Cody M., Seth A. Strom, Dean E. Riechers, Adam S. Davis, Patrick J. Tranel, and Aaron G. Hager. "Characterization of a waterhemp (Amaranthus tuberculatus) population from Illinois resistant to herbicides from five site-of-action groups." Weed Technology 33, no. 03 (May 23, 2019): 400–410. http://dx.doi.org/10.1017/wet.2019.19.

Full text
Abstract:
AbstractExperiments were initiated to characterize a waterhemp population (CHR) discovered in a central Illinois corn field after it was not controlled by the 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor topramezone. Field experiments conducted during 2014–2015 indicated that acetolactate synthase (ALS)-, protoporphyrinogen oxidase (PPO)-, photosystem II (PSII)-, and HPPD-inhibiting herbicides and the synthetic auxin 2,4-D did not control the CHR population. Laboratory experiments confirmed target site–based resistance mechanisms to ALS- and PPO-inhibiting herbicides. Herbicide doses required to reduce dry biomass 50% (GR50) were determined in greenhouse dose–response experiments, and indicated 16-fold resistance to the HPPD inhibitor mesotrione, 9.5-fold resistance to the synthetic auxin 2,4-D, and 252-fold resistance to the PSII inhibitor atrazine. Complementary results from field, laboratory, and greenhouse investigations indicate that the CHR population has evolved resistance to herbicides from five sites of action (SOAs): ALS-, PPO-, PSII-, and HPPD-inhibiting herbicides and 2,4-D. Herbicide use history for the field in which CHR was discovered indicates no previous use of 2,4-D.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "4-HPPD"

1

Lee, Meng Huee. "Studies on ketoacid-dependent dioxygenases involved in amino acid metabolism." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362049.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Shie, Tien-Lan, and 謝天嵐. "PartⅠ、Mechanistic Studies of Isomerization of Enol Esters Derived from Triketone and Rational Design of Novel Naphthoquinone-based Derivatives as a Potential Redox Switch.PartⅡ、Efforts to Acquire the Co-crystal Structures of 4-HPPD in Complex with." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/56976275532345619819.

Full text
Abstract:
碩士
東海大學
化學系
94
PartⅠ、Mechanistic Studies of Isomerization of Enol Esters Derived from Triketone and Rational Design of Novel Naphthoquinone-based Derivatives as a Potential Redox Switch. ( A ) The fluorescence-sensitive property of 3-acetyl-7-dimethylamino- 4-hydroxy-2H-chrome-2-one and its derivatives has been designed, synthesized and used to differentiate the two possible mechanisms of enol ester isomerization derived from 2-acyl-1,3-cyclohexanediones. The results suggested that the mechanism involving first 1,5-acyl transfer and following by 1,5-hydrogen shift is unlikely. ( B ) Naphtho[2,3-c]pyran-5,10-dione-based derivatives have been designed and synthesized in six steps with an overall yield of 50%. Compounds 27d、27e and 27f are red before reduction, and turned colorless when reduced by zinc in acetic acid. They can revert to original red color within seconds when the reducing agent is removed. These results suggested that compounds 27d、27e and 27f may have the potential to function as redox switches. PartⅡ、Efforts to Acquire the Co-crystal Structures of 4-HPPD in Complex with a Cyclopropanecarbonyl Containing Inhibitor Diketonitrile. A cyclopropanecarbonyl derivative was found to be 15 times more potent than the corresponding isopropylcarbonyl analogue as inhibitor of 4-hydroxyphenylpyruvate dioxygenase (4-HPPD). We speculated that the carbonyl oxygen atom of the cyclopropanecarbonyl derivative is metal-chelated with the enzyme active site iron. This specific interaction subsequently caused the cyclopropyl group of the molecule to adopt a fixed bisected conformation, which may behave as a novel induced conformation-restricted enzyme inhibitor. In an effort to gain evidence to support this hypothesis, We purified 4-HPPD and synthesized diketonitrile, and both of them were sent to the National Synchroton Radiation Research Center in Hsinchu for co-crystallization. We expect that the results will shed light on the conformation of the cycloproprane group of inhibitor in the active of 4-HPPD.
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "4-HPPD"

1

"4. Table of systems where ternary HPPE data were published only in graphical form as phase diagrams or related figures." In CRC Handbook of Thermodynamic Data of Aqueous Polymer Solutions, 383. CRC Press, 2004. http://dx.doi.org/10.1201/9780203998205-145.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "4-HPPD"

1

Hadorn, Jean-Christophe. "Solar and Heat Pumps Systems . IEA SHC Task 4 - HPP Annex 38 - Status after 1.5 Years." In ISES Solar World Congress 2011. Freiburg, Germany: International Solar Energy Society, 2011. http://dx.doi.org/10.18086/swc.2011.26.05.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic '4-HPPD' for particular source types:
Journal articles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography