Dissertations / Theses on the topic '4+2 diene'
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Williams, Julian Outfin. "An investigation of the synthetic potential of cyclohexa-3,5-diene-cis-1,2-diol and some related compounds with special reference to [4 + 2] and [2 + 2] cycloaddition reactions." Thesis, University of Exeter, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305838.
Full textKöhler, Frank. "Synthese von Bi-2H-azirin-2-ylen und deren Valenzisomerisierung zu Diazinen." Doctoral thesis, Universitätsbibliothek Chemnitz, 2002. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-200200926.
Full textChreim, Yamama. "Synthese de polymeres organosilicies par polycondensation de dienes polycycliques." Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR13134.
Full textPingali, Aparna. "Synthesis and X-ray Diffraction Structures of 2-(2-thienylidene)-4,5-bis-(diphenylphosphino)-4-cyclopenten-1,3-dione and fac-BrRe(CO)3[2-(2-thienylidene)-4,5-bis(diphenylphosphino)-4-cyclopenten-1,3-dione]." Thesis, University of North Texas, 2005. https://digital.library.unt.edu/ark:/67531/metadc4942/.
Full textMelzer, Antje. "Vinylazide - Synthesen und Reaktionen." Doctoral thesis, [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=968777910.
Full textHunt, Sean W. Richmond Michael G. "Synthesis and characterization of platinum(II)(2-(9-anthracenylylidene)-4,5-bis(diphenylphosphino)-4-cyclopenten-1,3-dione)(dichloride), platinum(II)(2-(9-anthracenylylidene)-4,5-bis(diphenylphosphino)-4-cyclopenten-1,3-dione(maleonitriledithiolate), and platinum(II)(4,5-bis(diphenylphosphino)-4-cyclopenten-1,3-dione)(4-methyl-1,2-benzene dithiol)." [Denton, Tex.] : University of North Texas, 2009. http://digital.library.unt.edu/ark:/67531/metadc12135.
Full textHunt, Sean W. "Synthesis and Characterization of Platinum(II)(2-(9-anthracenylylidene)-4,5-bis(diphenylphosphino)-4-cyclopenten-1,3-dione)(dichloride), Platinum(II)(2-(9-anthracenylylidene)-4,5-bis(diphenylphosphino)-4-cyclopenten-1,3-dione(maleonitriledithiolate), and Platinum(II)(4,5-bis(diphenylphosphino)-4-cyclopenten-1,3-dione)(4-Methyl-1,2-benzene dithiol)." Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc12135/.
Full textSouza, Severino Araújo de. "Estudos químicos e biológicos de compostos heterocíclicos derivados dos núcleos imidazolidina-2,4-diona e 2-tioxoimidazolidina-4-ona." Universidade Federal da Paraíba, 2015. http://tede.biblioteca.ufpb.br:8080/handle/tede/9023.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
The breakthrough occurred in the scientific world involving chemical and pharmacological studies of heterocyclic are the result of the large investment from pharmaceutical companies and research centers in universities. Synthetic Heterocyclic compounds stand out because of the possibilities these compounds present several different biological properties. Structural changes in imidazolidínico and tioimidazolidínico rings can change their chemical, physical properties and produce biological effects with a variety of useful applications. The objective of this work was the synthesis and characterization of heterocyclic compounds of imidazolidine-2,4-dione class and 2-thioxo-imidazolidine-4-one in order to investigate their pharmacological potential as antimicrobial, antinociceptive, anti-tumor and anticonvulsant and study their thermal stability. The compounds were obtained in two steps: first, reacted sodium cyanide, ammonium chloride, methylammonium chloride, isopropylammonium chloride and substituted aromatic aldehydes to, followed by acid hydrolysis to form the amino acid derivatives of glycine. In the second stage, there was the reaction of amino acids prepared with potassium isocyanate and ammonium isothiocyanate and / or phenyl isocyanate and / or phenyl isothiocyanate followed by acid hydrolysis to form the imidazolidínicos derivatives: IM-15; HPA-05; HPA-09; HPA-10; HPA-14; HPA-15A; HPA-15B; HPA-15C; HPA-15D; HPA-15E; HPA-15F; HPA-15G; HPA-15H; HPA-15J and tioimidazolidínicos: HPA-03; HPA-04; HPA-08; HPA-11; HPA-15I; HPA-15M. The structures of the synthesized compounds were characterized by IR absorption spectroscopy, 1H-NMR and 13C-NMR. With the synthesized compounds investigated the potential front Antimicrobial studies, antinociceptive, anticarcinogenic and CNS. Also evaluated the thermal stability of the synthesized compounds and in silico studies.
O grande avanço ocorrido no mundo científico envolvendo os estudos químicos e farmacológicos de heterocíclicos são frutos do grande investimento das indústrias farmacêuticas e dos centros de pesquisas nas universidades. Os compostos heterocíclicos sintéticos se destacam devido às possibilidades existentes nesses compostos de apresentar várias propriedades biológicas diferentes. Modificações estruturais nos anéis imidazolidínico e tioimidazolidínico podem alterar suas propriedades químicas, físicas e produzir efeitos biológicos com uma grande variedade de aplicações úteis. O objetivo desse trabalho foi a síntese e caracterização de compostos heterocíclicos da classe imidazolidina-2,4-diona e 2-tioxo-imidazolidina-4-ona com a finalidade de investigar suas potencialidades farmacológicas como antimicrobianos, antinociceptivos, antitumoral e anticonvulsivante e estudar sua estabilidade térmica. Os compostos foram obtidos em duas etapas: na primeira, fez-se reagir cianeto de sódio, cloreto de amônio, cloreto de metilamônio, cloreto de isopropilamônio e aldeídos aromáticos para substituídos, seguido de hidrólise ácida para a formação dos aminoácidos derivados da glicina. Na segunda etapa, fez-se a reação dos aminoácidos preparados com isocianato de potássio e isotiocianato de amônio e/ou fenilisocianato e/ou fenilisotiocianato seguido de hidrólise ácida formando os derivados imidazolidínicos: IM-15; HPA-05; HPA-09; HPA-10; HPA-14; HPA-15A; HPA-15B; HPA-15C; HPA-15D; HPA-15E; HPA-15F; HPA-15G; HPA-15H; HPA-15J e tioimidazolidínicos: HPA-03; HPA-04; HPA-08; HPA-11; HPA-15I; HPA-15M. As estruturas dos compostos sintetizados foram caracterizadas através da espectroscopia de absorção no IV, de RMN de 1H e RMN de 13C. Com os compostos sintetizados investigou a potencialidade frente aos estudos Antimicrobianos, Antinociceptivos, Anticarcinogênico e sobre o SNC. Avaliou também a estabilidade térmica dos compostos sintetizados e os estudos in silico.
Hayes, Patricia. "Premiers exemples d'heterocycloadditions 4 + 2 intermoleculaires de 3-sulfinyloxabuta-1,3-dienes chiraux application a la synthese de pheromones acetaliques." Le Mans, 1998. http://www.theses.fr/1998LEMA1002.
Full textTang, Yongping. "Investigation of the stereochemistry of macrocyclic ligand complexes: [Ni(tetramethylcyclam)][superscript]2+ and [brace]Co(Me[subscript]6[14]dieneN[subscript]4)CI[subscript]2+[brace]." Thesis, Georgia Institute of Technology, 1990. http://hdl.handle.net/1853/26951.
Full textFossey, Christine. "Synthèse de nucléosides pyrimidiniques à visée antivirale (anti-sida) possédant un aglycone original : la thiéno (3,2-d) pyrimidine-2, 4-dione." Caen, 1992. http://www.theses.fr/1992CAEN4047.
Full textCOLSON, PIERRE-JEAN. "Des acyl-1 et acyl-2 dienes fer-tricarbonyle aux complexes d'epoxydes dieniques. Synthese totale du (5s,6s)-leucotriene lta#4." Université Louis Pasteur (Strasbourg) (1971-2008), 1991. http://www.theses.fr/1991STR13112.
Full textShen, Huafeng. "Substitution Chemistry of Ruthenium Clusters with the Diphosphine Ligands: 4,5-Bis(Diphenylphosphino)-4-Cyclo-Penten-1,3-Dione (bpcd), (Z)-Ph₂PCH=CHPP₂ and 3,4-Bis(Diphenylphosphino)-5-Methoxy-2(5H)-Furanone (bmf)." Thesis, University of North Texas, 1997. https://digital.library.unt.edu/ark:/67531/metadc935834/.
Full textGomez, Catherine. "Elaboration de nouveaux inhibiteurs mixtes ECA/ECE pour le traitement de l'hypertension." Phd thesis, Université d'Orléans, 2008. http://tel.archives-ouvertes.fr/tel-00465126.
Full textXing, Dongxia. "Stereoselective Solid-State NaBH₄ Reduction of 1-Methylpentacyclo[5.4.0.0²,⁶.0³,¹⁰,0⁵,⁹]undecane-8, 11-Dione, Synthesis and Chemistry of Strained Alkenes, and Chemical and Microbial Synthesis of Racemic and Optically Active (S)-4-Hydroxy-2-Cyclohexenone." Thesis, University of North Texas, 1995. https://digital.library.unt.edu/ark:/67531/metadc278368/.
Full textRenard, Annabelle. "Synthèse d'analogues spiraniques de nucléosides et leur incorporation dans des oligonucléotides." Université Joseph Fourier (Grenoble), 1999. http://www.theses.fr/1999GRE10031.
Full textHennequin, Laurent. "Nouvelle méthode de préparation de composés dicarbonylés-1,5 : application à la synthèse de substances naturelles." Rouen, 1986. http://www.theses.fr/1986ROUES026.
Full textLin, Yu-Hsien, and 林育. "The Synthesis and Chemistry of Tricyclo[3.2.2.02,4]nona-2(4),6-diene." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/21989038887592188264.
Full text輔仁大學
化學系
87
Tricyclic 1,2-fused cyclopropene:tricyclo[3.2.2.02,4]nona- 2(4),6-diene 44 is formed by the elimination reaction of2-bromo- 4-chlorotricyclo[3.2.2.02,4]non-6-ene 56 with methyllithium. The products of the Diels-Alder reaction with the compound 44 and 1,3-diphenyl-isobenzofuran (DPIBF) are only endo-addition from the bicyclo[2.2.2]octa-2,5-diene system, and exo- and endo-addition for the cyclopropene system. These products are endo-endo adduct 58 and exo-endo adduct 59. Base on these results, the repulsion of the vinylene group (CH=CH group) and DPIBF higher than that of ethylene group (CH2-CH2 group) and DPIBF. Compound 44 isomerizes to 8-methylenebicyclo[3.2.1]octa- 1,6-diene 65 which is trapped by DPIBF. Compound 58 isomerizes to form compound 60 by irradiation. Both 58 and 59 are stable at refluxing tetrahydrofuran temperature and at UV light. In the presence of trifluoroacetate acid, compound 58 hydrolyzes to form 72, and 59 hydrolyzes in trifluoroacetate acid to form 71 and 72. Both 71 and 72 undergo dehydration and deformylation to give 70. In neat condition, compound 44 will isomerize to vinyl carbene 66 follows by insertion reaction to form 74.
TSOU, YI-JUNG, and 鄒易融. "(I)The Synthesis and Chemistry of 8-Oxatricyclo[3.2.1.02,4]octa-2(4),6-diene(II)Study and Chemistry of exo-2-Bromo-4-Chloro-8-Oxatricyclo[3.2.1.02,4]octa-6-ene and endo-2-Bromo-4-Chloro-Oxatricyclo[3.2.1.02,4]octa-6-ene." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/hjksu6.
Full text輔仁大學
化學系
106
(I)The 1,2-bridged polycyclic cyclopropene, 8-Oxatricyclo[3.2.1.02,4]octa-2 (4),6-diene has been synthesized by elimination of exo-2-bromo-4-chloro-8-oxa tricyclo[3.2.1.02,4]octa-6-ene or endo-2-bromo-4-chloro-8-oxatricyclo [3.2.1.02,4]octa-6-ene, cyclopropane 39 was treated with DPIBF to form exo-endo adduct 45﹑exo-exo adduct 46﹑α,β-unsaturated ketone adduct 47 isomerized by exo-endo 45﹑ adduct 48 treated by compound 46 with DPIBF﹑adduct 49 and 50 hydrogenated by adduct 52 and 53﹑unknown adduct 51. (II)exo η2 complex 76 and endo η2 complex 77 has been synthesized by trapping exo-2-bromo-4-chloro-8-oxatricyclo[3.2.1.02,4]octa-6-ene and endo-2-bromo-4-chloro-8-oxatricyclo[3.2.1.02,4]octa-6-ene with iron tetracarbonyl and proved the mechanism of compound 56-59 and 61-65. In addition, there were achieved a new synthestic route to provide tropone derivatives with high yield by use cyclopropenes.
Pon-Won, Chen, and 陳鵬文. "Cycloaddition Reactions of 4-Sulfur-substituted-2-pyridones with Conjugated Dienes." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/71875928223936994613.
Full text輔仁大學
化學系
95
This thesis mainly studies the [4+2] cycloaddition reactions of 4-sulfur-substituted 2-pyridones 6, 7, 18, and 20 with several electron-rich dienes, and explores the regio- and stereoselectivity of these reactions. Pyridone 6 reacts as a dienophile with cyclic and acyclic conjugated dienes to give the expected cycloaddition products. Pyridone 7, however, bearing a diene moiety itself, exhibits quite unusual reaction patterns with cyclopentadiene: it reacts as a diene at high temperatures, but reacts both as a dienophile and a diene at 50 oC. The reactivity of sulfoxide 18 is similar to that of sulfone 6, whereas the less-conjugated sulfone 20 is less reactive than compound 6. We have used the PM3 semi-empirical method of HyperChem to calculate the reactivity and regioselectivity of these cycloaddition reactions, and have found that most of the experimental results fit quite well with the theoretical calculations.
Lai, Chun-Chia, and 賴俊嘉. "Density Functional Theory study of [8+2] and [4+2] Cycloaddition Reactions of 2-Oxo-2H-cyclohepta[b]furan derivatives with Dienes." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/80744404394630730734.
Full text國立彰化師範大學
化學系
90
Abstract Cycloaddition reactions of 2-Oxo-2H-cyclohepta[b]furan derivates participating as 8π and 4π components respectively toward dienes are described. We use density functional theory (DFT) calculations in the study of transition states and products of title reactions. Possible [4+2] and [8+2] reaction paths were investigated. Our results show that Part 1: [8+2] endo path, is the most likely both thermodynamically and kinetically. The distinct selectivity of the [8+2] endo path over the [4+2] endo one was explained in terms of the secondary orbital interaction (SOI). Part 2: we simulate the substituent effect and compare the result with experiment, the result shows that the more exothermic the reaction, the higer yield the product. Our theoretical prediction is consistent with the experimental observation. Part 3: we apply hetero-atom subsititutions, the result shows that new bicyclo compounds have more aromaticity, leading to increase in the relative energies of intermediates and transition structures. We thus conclude that the cycloaddition reactions with hetero-atom subsititutions are less likely to occur.
顏學仁. "Synthesis and biological activity of naphtho [ 2, 3-d] imidazole-4, 9-dione and its related compounds." Thesis, 1987. http://ndltd.ncl.edu.tw/handle/95205513988626943862.
Full textLording, William James. "A deeper understanding of the Diels–Alder reaction." Phd thesis, 2010. http://hdl.handle.net/1885/11776.
Full textAbid, Obaid-ur-Rahman [Verfasser]. "Synthesis of functionalized 4-chlorophthalates, 2-naphthoates, 2-fluorobiaryls, and arylpyridines by cyclocondensation reactions of 1,3-bis(silyloxy)-1,3-butadienes and related dienes and by palladium(0) catalyzed cross coupling reactions / vorgelegt von Obaid-ur-Rahman Abid." 2010. http://d-nb.info/100780808X/34.
Full textHuang, Chin-Neng, and 黃志能. "Part I、Design and synthesis of 3-(2-Phenyl-4H-thio-chromen-4-yildene)-3H-chromene-2,4-dione derivatives as potential redox switchesPart II、Design and Synthesis of 7-N,N-dimethylamino-4-hydroxycoumarin-based derivatives as potential organic photochromi." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/33645529616308159980.
Full text東海大學
化學系
95
Part I、Design and synthesis of 2'-phenyl-[3,4']bichromenylidene -2,4-dione derivatives as potential redox switching Tow 3-(2-Phenyl-4H-thiochromen-4-yildene)-3H-chromene-2,4-dione derivatives were synthesized in several steps from thiophenol and 4-hydroxycoumarins with overall yields of 65 and 67%. The prepared compounds 16 and 21 instantly changed from either purple or bule to colorless when treated them with sodium borohydride in methanol. The resulting reduced compounds reverted to their original colors after the reducing agent was removed. While no fluorescence of N,N-dimethylamino substituted compound 21 was detected prior to reduction, the reduced compound 22 emitted fluorescence with the quantum yield of 0.19 in methanol. Part I: Design and Synthesis of 7-N,N-dimethylamino- 4-hydroxycoumarin-based derivatives as potential organic photochromic colorants and redox switches A series of 2H-pyrano[3,2-c]chromen-5-one derivatives were synthesized. Their photochromic properties were investigated by the UV-vis absorption spectroscopy, and were compared to that of chromenes. Compounds 11 and 13a-b mainly existed in the ring-opened forms when one or two phenyl groups were incorporated on the 2-position. Incorporation of a methyl substituent on 3-position completely abolished their photochromic behavior. Compounds 5b with an N,N-dimethylamino group on the aromatic ring displayed an increasing shoulder absorption in the visible region and a distinct change of color upon UV irradiation.
Kappelmayer, Diane [Verfasser]. "Die Expression der EGF-Rezeptor-Familie (HER-1, HER-2, HER-3, HER-4) im extravillösen Trophoblasten im Vergleich zwischen normalen humanen Plazenten und Plazenten von Frauen mit hypertensiven Schwangerschaftserkrankungen / vorgelegt von: Diane Kappelmayer." 2007. http://d-nb.info/988408465/34.
Full textBeerlink, Johannes. "Totalsynthese der Mansouramycine A-E aus Streptomyces sp. und Rhodium-katalysierte 1,2-Additionen an cyclische Enone." Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-0006-AD4C-2.
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