Dissertations / Theses on the topic '3PO'
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Courtillot, Irène. "Première observation de la transition fortement interdite 1SO - 3PO du strontium, pour une horloge optique à atomes piégés." Paris 6, 2003. https://tel.archives-ouvertes.fr/tel-00004039.
Full textNUKALA, SARATH BABU. "BIOANALYTICAL AND PROTEOMIC APPROACHES IN THE STUDY OF PATHOLOGIC ECS DYSFUNCTIONALITY, OXIDATIVE STRESS AND THE EFFECTS OF PFKFB3 MODULATORS." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/644236.
Full textBareš, Vladislav. "Marketing poskytovatele 3PL." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-77879.
Full textČechák, Pavel. "3PL v inbound logistice." Master's thesis, Vysoká škola ekonomická v Praze, 2008. http://www.nusl.cz/ntk/nusl-9146.
Full textCoňková, Petra. "Potřeby klienta 3PL poskytovatele." Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-197881.
Full textLinér, Lina. "3go : en sparkcykel för äldre." Thesis, Konstfack, Industridesign, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:konstfack:diva-2837.
Full textExamensarbete Industridesign kandidatexamensarbete
Lichnovská, Eva. "Analýza druhů kontraktů s 3PL." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-71749.
Full textThomas, Bertrand. "Etude des terres rares associées aux particules et sédiments marins, cas de la marge continentale du Golfe de Gascogne (Atlantique N. -E. ) et de la dorsale médio-Atlantique (37o-38o)." Pau, 1998. http://www.theses.fr/1998PAUU3019.
Full textRadouani, Abdelhak. "Réaction des atomes métastables de gaz rares (Ar*(3p2,0), Kr*(3p2) et Xe*(3p2)) avec le silane." Grenoble 1, 1986. http://www.theses.fr/1986GRE10143.
Full textLescop, Benoît. "Contribution à l'étude par spectroscopie électronique de l'ionisation Penning de CO2 N2 et C2H2 par impact d'atomes de néon et d'hélium dans les états métastables Ne*(3P2, 3P0) et He* (21S, 23S)." Brest, 1997. http://www.theses.fr/1997BRES2027.
Full textNguyen, Trong Tuan, and Thi Khanh Phuong Phan. "The Influence of E-commerce for Third-party Logistics : Typical demands for 3PL services and the adaptation by 3PL." Thesis, Internationella Handelshögskolan, Högskolan i Jönköping, IHH, Centre of Logistics and Supply Chain Management, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-20693.
Full textLi, Zhang, and Zhou Shuya. "Drivers and barriers of cold chain logistics in Chinese 3PL companies : A case study on two Chinese 3PL companies." Thesis, Högskolan i Gävle, Avdelningen för Industriell utveckling, IT och Samhällsbyggnad, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-14514.
Full textBrännhult, Danny, and Gustaf Kapanen. "The Value of Information Sharing in a 3PL-relationship." Thesis, Internationella Handelshögskolan, Högskolan i Jönköping, IHH, Företagsekonomi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-18826.
Full textConde, Roldan Frank Geremy. "Optimization cost of operations in a 3PL for vaccines." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2020. http://hdl.handle.net/10757/653465.
Full textThe process that a vaccine passes through the cold supply chain tends to require a high quality standard. The importance of this product for human consumption has become necessary throughout the world. This research will take into account the main factors that affect the efficiency and performance of the temperature sensitive product; a tool will be applied that improves the conditions in the storage and in the method of work focused under an analysis of operation. In addition to this, we will analyze a case study of a logistics operator in Peru, improvements in the most important and critical processes will be proposed. As a validation method, a simulation of the proposed model will be used and will be carried out using the Arena software. Plant distribution techniques will also be applied to evaluate the design. Results decrease the selection process by 27% and eliminate errors that occur. In a new design, the cost of the trip decreases by 48%. Another result that has a direct impact on the chain is the systematic reduction of the cost associated with the supply and chain of the vaccine, which on average is reduced by 10% of the total.
Trabajo de investigación
Michalíková, Hana. "Role 3PL a 4PL poskytovatelů v kontejnerové námořní přepravě." Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-199747.
Full textGredelj, Melita, Marcus Källberg, and Emine Sadikaj. "Konsumenternas krav på flexibilitet i order- och leveransprocessen inom E-handeln : En fallstudie på PostNord Ljungby Strålfors." Thesis, Linnéuniversitetet, Institutionen för ekonomistyrning och logistik (ELO), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-76416.
Full textContext: Flexibility, or the ability to respond to uncertainty in the environment without causing shortcomings in time, effort, cost or performance has become increasingly important. Flexibility in a delivery means that companies should be able to implement changes in an ongoing delivery in order to meet customer needs. Purpose: The purpose of this study is to investigate what requirements consumers have on e-commerce flexibility, and how e-commerce companies can adapt to and be better at managing consumer demand for flexible deliveries. Even how e-commerce companies can develop changeability in an environment that is constantly changing. Method: The study is based on a qualitative research method and has been conducted through a case study. The study has been conducted through a semi-structured interview at the case company, but also through email interviews and surveys to the case company's 3PL customers. The study has a realistic approach and a deductive approach. Results: There are various shortcomings in PostNord's order and delivery process: Lack of integration with 3PL customers, lack of how delivery should be done, lack of delivery of same-day, shortage of time intervals, and lack of follow-up after delivery. These can be resolved by increasing integration with 3PL customers through systems and agreements, increasing consumer choice in time and place through collect-in-store, agility, business development to enable consumers to participate in meeting the requirements of flexibility, self -collecting to reduce the number of failed deliveries, performance matrices to determine a customer service strategy and by hiring more staff.
Ketels, Helge. "Automotive third party logistics in China." Thesis, Högskolan i Gävle, Avdelningen för Industriell utveckling, IT och Samhällsbyggnad, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-10497.
Full textVinš, Marek. "Specifika outsourcingu logistických služeb." Doctoral thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-163047.
Full textBartels, Joanna [Verfasser]. "Die Bedeutung von Serum – microRNAs (miR-367-3p, miR-371a-3p, miR-372-3p, miR-373-3p) als Biomarker beim Hodentumor / Joanna Bartels." Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1080592091/34.
Full textChew, Chee Mun, and Graeve Denis 1979 De. "Service bundling opportunities for a 3PL in the value network." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/34972.
Full textThis electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Originally written by two authors for two different degrees: Massachusetts Institute of Technology, Sloan School of Management, Management of Technology Program (Mr. Chew); and, Massachusetts Institute of Technology, Engineering Systems Division, Technology and Policy Program (Mr. de Graeve). Mr. Chew graduated June 2003; Mr. de Graeve did not graduate until June 2004, and submitted the following thesis with title: Framework for the study of governance in the supply networks
Includes bibliographical references (leaves 96-99).
The 3PL industry is currently experiencing rapid growth, high fragmentation and intense competition. In order to survive and stay relevant going forward 3PLs need to re-assess their current position in the value network and develop a clear strategy to position themselves as strategic business partners for the long term. This thesis first explores the supply chain challenges and needs of the major stakeholders in the value network. It then tries to create a roadmap identifying the major opportunities which 3PLs should optimize in order to become true value-added service providers and long term strategic business partners in the value network.
by Chee Mun Chew & Denis de Graeve.
S.M.M.O.T.
Emele, Jude. "The Potential of 3PL Involvement in an Asphalt Manufacturing Project." Thesis, Högskolan i Gävle, Avdelningen för Industriell utveckling, IT och Samhällsbyggnad, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-22652.
Full textWillner, Daniel, and Stavros Zafeiridis. "Creating competitive advantage for the 3PL sector by identifying retailers' needs." Thesis, Internationella Handelshögskolan, Högskolan i Jönköping, IHH, Centre of Logistics and Supply Chain Management, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-18310.
Full textBertilsson, Hannes, and Patric Freijd. "Prestationsmål inom 3PL : Prestationsmålens påverkan på en ekonomisk och social hållbarhet." Thesis, Tekniska Högskolan, Högskolan i Jönköping, JTH, Industriell organisation och produktion, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-41652.
Full textSyfte – Syftet med denna studie är Att undersöka prestationsmål inom ett 3PL-företag och dess påverkan på ekonomisk och social hållbarhet. För att uppfylla studiens syfte har två frågeställningar formulerat: Hur används prestationsmål inom ett 3PL-företag för att öka företagets ekonomiska värde? Hur påverkas de anställda av de nuvarande prestationsmålen? Metod – För att uppfylla studiens syfte har en fallstudie genomförts på ett tredjepartslogistikföretag där de använder prestationsmål för att mäta individers prestation. Två stycken datainsamlingstekniker användes för att samla in empiri till studien, intervjuer och observation. Utöver dessa två datainsamlingstekniker har en litteraturstudie genomförts. Resultat – Studien resulterade i att prestationsmål har en påverkan både på ett företags ekonomiska och sociala hållbarhet. Prestationsmålen används av tredjepartslogistikföretag för att kunna förhandla ett hållbart kontrakt med sina kunder och tillföra tillväxt till företaget och detta påverkar ett företagets anställda både positivt och negativt. Implikationer – Studien har bidragit till att belysa de kunskapsgap som identifierats vilka är att prestationsmål på individnivå är ett relativt outforskat område och att RBV inte har använts inom lagerverksamhet tidigare. och hur prestationsmål påverkar de anställda inom ett 3PLföretag. Begränsningar – Studien som genomfördes var en enfallstudie vilket innebär att studien inte är lika generaliserbar som en flerfallstudie. Intervjuernas respondenter hade erfarenhet inom lagerverksamhet och märkte därför ingen större påverkan av prestationsmålen. Studien hade stärkts av att ha respondenter som inte har erfarenhet inom lagerverksamhet då de kan ha en annan syn på prestationsmål.
Abboud, Mohamad Moulham. "Simulation of 3ph induction motor in Matlab with VVVF starting method." Thesis, Högskolan i Halmstad, Energivetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-31102.
Full textNumera är tre-fas asynkronmotorer i stor utsträckning på industriella och andra typer av processer. Därför är det mycket viktigt att ha exakt kunskap om en induktionsmotorprestanda för att ha en uppfattning om dess driftsförhållanden . Denna studie är en fortsättning av en tidigare, där direkt och mjukstart metoder för trefasmotorer har simulerats och jämförts. Såsom i den tidigare studien, är teorin bakom denna en baserat på representerar den verkligamotorn av en uppsättning ekvationer och värden i Matlab, som bildar en motsvarande ideell motor på ett sätt där alla de fysiska effekterna är likartade . Motorn startas under tre olika frekvenser i VVVF metod med stöd simulering av ström, vridmoment, hastighet, effektivitetoch effektfaktorn kurvor. Därefter, resultaten av de tre startmetoder diskuteras och jämföras.
في الوقت الحالي تستخدم المحركات التحريضية ثلاثية الطور بشكل واسع في التطبيقات الصناعية و غيرها. و لهذا فإن المعرفة الدقيقة بأداء المحرك التحريضي أساسية لإعطاء فكرة عن ظروف تشغيله. إن هذه الدراسة هي تتمة لدراسة سابقة حيث تمت محاكاة و مقارنة طريقتي الإقلاع المباشر و الناعم للمحرك التحريضي ثلاثي الطور. كما في الدراسة السابقة, فإن هذه الدراسة مبنية على تمثيل المحرك الحقيقي بمجموعة من المعادلات و القيم الاسمية في برنامج ماتلاب لتكوين محرك مثالي مطابق, بحيث تكون جميع الآثار الفيزيائية مماثلة للمحرك الحقيقي. يتم إقلاع المحرك عند ثلاث ترددات مختلفة بطريقة تغيير التردد و التوتر و يتم محاكاة هذا الإقلاع عبر منحنيات التيار، العزم، السرعة، المردود و عامل الاستطاعة ثم تقارن نتائج طرق الإقلاع الثلاثة.
Häck, Björklund Fredrik, and Oscar Järnhäll. "Tredje- och fjärde-parts logistiken : Jämförande studie mellan 3PL och 4PL." Thesis, Malmö universitet, Institutionen för Urbana Studier (US), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-45493.
Full textThis study seeks to examine the different service offers for logistical outsourcing through 3PL and 4PL suppliers and their role in supply chains. This with the background of the trends within the industry regarding outsourcing, where companies are seeking new and smart solutions for their business, and to maintain and strengthen their competitiveness. To examine these relationships of the suppliers, a qualitative study has been conducted, where four informants have participated in semi structured interviews with questions that have their base in the presented theories. The informants that participated in the study have their background in supplier-companies with services of both 3PL and 4PL solutions. The analysis of the empirical material gathered through the interviews has shown how the solutions differ, primarily in regards to their physical resource utilization, but also the similarities in how greater values can be created for the customer organizations. Through the study the need for both research and development of services can be seen, to be able to differentiate the two alternatives for logistical outsourcing.
Virta, Damon. "Procurement of a Third party logistics company : A possible benchmarking method." Thesis, KTH, Fastigheter och byggande, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-102176.
Full textGong, Wei, and Xuan Kan. "Logistic Service Development of E-commerce : A case study of AliExpress - an online international trade platform in China." Thesis, Internationella Handelshögskolan, Högskolan i Jönköping, IHH, Marketing and Logistics, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-21335.
Full textTahir, Muhammad Usman, Hammad Tabassum, Muhammad Arshad, and Saeed Ahmad. "Logistics outsourcing - 3PL & 4PL : A Survey on Pakistani manufacturing and exporting companies." Thesis, Växjö universitet, Ekonomihögskolan, EHV, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-11454.
Full textAbboud, Mohamad Moulham. "Simulation of 3ph induction motor in Matlab with Direct and Soft starting methods." Thesis, Linnéuniversitetet, Institutionen för fysik och elektroteknik (IFE), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-45888.
Full textBrahimi, Mirlinda, and William Jonasson. "Grön Logistik : Betydelsen av hållbara transporter för kunderna när de väljer 3PL-företag." Thesis, Linnéuniversitetet, Institutionen för ekonomistyrning och logistik (ELO), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-105105.
Full textBOSSAKOV, PETKO VESELINOV. "Information Asymmetry in Contract Logistics: Problems and Solutions." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2017. http://hdl.handle.net/10281/170853.
Full textThis thesis aims to develop a business concept for a practical software tool for increasing sales and promoting customer loyalty by providing IT-based solutions that help customers solve information asymmetry problems in third-party logistics, and to discuss the potential advantages of such a model along with possible approaches for its implementation. Operational data obtained by an Italian intermediary firm providing transport, logistics and inventory management services to businesses was examined in an attempt to obtain an estimate of how likely information asymmetry conditions are to be present on the third-party logistics market in Italy. Several major players and innovative startups in other markets, characterized by their ability to capitalize on existing information asymmetries and providing solutions for reducing them, were studied. Finally, specific steps for implementing an information asymmetry-reducing business model in third-party logistics were considered.
Grevesmühl, Vasco, and Reza Chehreh. "Viable Options a Shipper has in Using Different Logistic Solutions." Thesis, KTH, Industriell ekonomi och organisation (Inst.), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-122717.
Full textAndersen, Alexander, and Ludvig Brewitz. "Collaboration within Supply Chains : Can conflicts be attributed to the different roles of logistics companies?" Thesis, Internationella Handelshögskolan, Högskolan i Jönköping, IHH, Centre of Logistics and Supply Chain Management (CeLS), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-30259.
Full textLiu, Jingting, and Zeying Huang. "The value co-creation in automotive-3PL relationship management : A case study in Sweden." Thesis, Internationella Handelshögskolan, Jönköping University, IHH, Företagsekonomi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-48590.
Full textOlsson, Jonas. "Tidsdriven ABC-kalkylering inom tredjepartslogistik : Tillämpningar för att driva produktivitet hos PostNord Logistics TPL i Norrköping." Thesis, Linköpings universitet, Logistik- och kvalitetsutveckling, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-142929.
Full textPostNord Logistics TPL AB (PostNord) is one of the largest third-party logistics providers in the Nordics. At the tire warehouse in Norrköping, PostNord performs logistics activities within inbound, storage, production and outbound for several retailers/distributors. Labor is by far the largest cost and hence the management focuses on productivity, for example by efficiency and improving precision in workforce management. The purpose of this study was therefore to develop a cost model based on Time-Driven Activity-Based Costing (TDABC) for the warehouse operations, which can be applied to support PostNord’s efforts to drive productivity. TDABC is a methodology to estimate the consumption of resources such as personnel and equipment caused by different transactions, products or customers. By modelling activities in time equations which are based on time estimates it is possible to show what impacts time consumption (man-hours required). Time equations for the three activities assembly, receiving and putaway were developed. The approach included verifying and processing data, regression analyses, time studies, interviews, observations and finalization and validation of the cost models in Excel. The finalized models proved to be reasonable and to offer promising precision day-to-day. Next, four user interfaces were developed; what-if analyses for assembly, receiving and putaway as well as staff scheduling for assembly. Via usability tests inspired by the think-aloud method it was shown that the applications were usable and expected to support the efforts to drive productivity by efficiency and precision in staffing. In the literature, there is an articulated need for further studies of the TDABC methodology, including the design process for TDABC and specifically the development of time estimates for the time equations. This study contributes to the methodology in the following four ways. 1) An overall method (process) for TDABC which future studies may utilize. 2) Learnings about specific aspects of the overall method regarding interviews, verifying and processing data, as well as the use of regression analysis and time study. 3) Examples of characteristics of the finalized cost models and implications of them. 4) Guidance regarding important choices for the modelling of time equations and implications of them.
Mendes, Sara Bruna Felício. "Avaliação de um sistema de gestão de armazenamento : um estudo de caso." Master's thesis, Instituto Superior de Economia e Gestão, 2014. http://hdl.handle.net/10400.5/8239.
Full textAs atividades logísticas foram desde sempre dependentes de informação. Esta realidade não mudou. Contudo, acentuou-se ao longo do tempo com a necessidade de informação exata e em tempo real. Para tal, as empresas de atividades logísticas deparam-se com a necessidade de avaliar os seus sistemas de gestão de informação, decidindo estrategicamente os investimentos sobre os mesmos. O presente trabalho de projeto debruça-se sobre a avaliação da adequação de um sistema de gestão de armazenamento às operações. Fá-lo através da adaptação de uma matriz para avaliação da adequação do sistema de gestão de armazenamento aos processos, a qual permite comparar as avaliações atribuídas. Esta matriz é composta por 11 processos, para os quais é avaliada a adequação do sistema atual, e a adequação desejada num horizonte de dois anos. Os dados recolhidos permitiram concluir quais os processos mais críticos em que a empresa terá de investir. Através da combinação dos dados recolhidos, com as sessões de trabalho em grupo e visitas aos armazéns, foi possível identificar diversas falhas extra sistema. O presente trabalho de projeto mostra o exemplo de uma empresa que percecionava deter um sistema mais adequado às suas operações do que o que foi demonstrado no estudo, demonstrando a importância da avaliação dos sistemas de informação.
Logistics activities have always been dependent on information. This reality has not changed. However, it has been accentuated arisen over time with the need for accurate information and in real time. To do this, logistics companies are faced with the need to evaluate their information management systems, making strategic decisions about its investments. This research project focuses on assessing the suitability of a warehouse management system. It does so by adapting a matrix for assessing the adequacy of the warehouse management system to its processes, which allows a comparison with the resulting ratings. This matrix is composed of 11 processes, for which the adequacy of the current system is assessed, as well as the desired adequacy on a two year horizon. The data collected permits to point the most critical processes in which the company will have to invest. By combining the data collected with group work sessions and visits to the warehouses, it was possible to identify several extra system failures. This work shows the example of a company that thought it held a system that was best suited to its operations than the one that was shown in the study, thus demonstrating the importance of evaluating the information systems.
Gao, Song. "The Exploration of the Relationship Between Guessing and Latent Ability in IRT Models." OpenSIUC, 2011. https://opensiuc.lib.siu.edu/dissertations/423.
Full textPetersen, Michael. "Laser-cooling of Neutral Mercury and Laser-spectroscopy of the 1S0-3P0 optical clock transition." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2009. http://tel.archives-ouvertes.fr/tel-00405200.
Full textTorsoni, Adriana Souza 1973. "Efeito hipotensor e estudos toxicologicos do complexo t-[RU(NH3)4P(OEt)3NO(PF6)3." [s.n.], 1999. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314594.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: A farmacodinâmica vascular da síntese endógena de NO ficou conhecida devido ao efeito de drogas nitrovasodilatadoras. Esses agentes exógenos, tais como o nitroprussiato de sódio, agem como doadores de NO e exercem efeito hipotensivo in vivo direto promovendo diminuição na resistência vascular sistêmica decorrente de um aumento nos níveis de GMP cíclico. Nosso interesse reside na possibilidade de complexos de rutênio transnitrosilaminados servirem como veículo para a liberação controlada de NO em sistemas biológicos e, assim, produzir efeitos farmacológicos. O objetivo desse trabalho foi investigar o efeito hipotensor e a toxicidade de um novo complexo de rutênio, o t-[Ru(NH3)4P(OEt)3NO](PF6)3 devido a sua habilidade em liberar NO espontaneamente em solução aquosa. Medidas diretas de PA foram realizadas em ratos Wistar machos adultos cronicamente instrumentados. O efeito hipotensor foi determinado em ratos conscientes (n=10) submetidos a injeções endovenosas "in bolus" de trans-[Ru(NH3)4P(OEt)3NO](PF6)3 e nitroprussiato de sódio (NaNP). Concentrações de 0,0025 a 0,08 µmoles/Kg do complexo de rutênio induziram resposta hipotensora imediata (PAM controle 104 ± 4,1 mmHg) em uma faixa de ação de 7 a 27%, similar ao efeito observado para o NaNP (11a 32%). Uma correlação dose-efeito positiva foi observada. A toxicidade foi avaliada em cultura de células (IC50) e pela toxicidade aguda em camundongos (LD50). Estudos da citotoxicidade foram conduzidos em cultura de hepatócitos (células metabolizantes), V79 (células não metabolizantes) e V79 tratada com o complexo biotransformado pelos hepatócitos. Hepatócitos de rato foram isolados pelo método de perfusão com colagenase em duas etapas do fígado inteiro. A viabilidade celular foi avaliada por três ensaios, os quais são indicativos de citotoxicidade: redução do MTT, incorporação do vermelho neutro (VN) e conteúdo de ácidos nuclêicos (DNA). Esses ensaios permitiram a avaliação dos valores de IC50 para o trans-[Ru(NH3)4P(OEt)3NO](PF6)3 em células V79 e hepatócitos. Na cultura de hepatócitos valores de IC50 superiores a 3,0 mM foram obtidos para todos os ensaios realizados, sugerindo uma baixa toxicidade do complexo. Para cultura de células V79, nossos resultados mostraram efeito citotóxico similar para os três ensaios investigados, com valores de IC50 ao redor de 2,0 mM, mostrando ser este composto menos tóxico que o NaNP (IC50 ~ 0,056 mM). O produto da biorransformação foi avaliado e mostrou baixa toxicidade para os ensaios de DNA, MTT e alta toxicidade para o VN, i.e., o composto biotransformado modificou a integridade lisossomal. A toxicidade aguda foi avaliada e um valor de LD50 igual a 216 mg/Kg foi obtido indicando baixa toxicidade do complexo in vivo.
Abstract: The vascular pharmacology of endogenously synthesised NO is largely predicted by the known effects of nitrovasodilator drugs. These exogenous agents, such as sodium nitroprusside, act as NO donors and exert direct hypotensive effects in vivo promoting a decrease in systemic vascular resistance by increasing levels of cyclic GMP. We have been interested in the possibility that trans-nitrosylammine ruthenium complexes, might serve as vehicles for the controlled delivery of NO into a biological system and thus display useful pharmacological effects, promoting hypotensive effect. The aim of this work was to investigate the hypotensor effect and toxicity of a new ruthenium complex t-[Ru(NH3)4P(OEt)3NO](PF6)3 due to their ability to spontaneously NO release in aqueous solution. Direct measurements of blood pressure were performed in chronically instrumented adult male Wistar rats. The hypotensor effect was determined in conscious rats (n=10) submitted to in bolus intravenous doses of the trans-[Ru(NH3)4P(OEt)3NO](PF6)3 and sodium nitroprusside (NaNP). Concentration range of 0.0025 to 0.08 µmols/Kg induced hypotensive response (MAP control: 104 ±4.1 mmHg) immediately in action range of 7 to 27% similar to that observed for NaNP effect (11 to 32%). A positive dose-effect correlation was observed. The toxicity was evaluated on cell culture (IC50) and by acute dose in mice. Cytotoxicity studies were carried out on cultures of rat hepatocytes (metabolizant cells), V79 (non-metabolizant cells) and V79 treated with the supernatant of the biotransformed complex by hepatocytes. Hepatocytes were isolated from adult male Wistar rats by the two-step collagenase liver perfusion. Cell viability was evaluated by three endpoints which are indicative of cytotoxicity: MTT reduction, Neutral Red Uptake (NRU) and Nucleic Acid Content (DNA). These assays permit the evaluation of IC50 values of trans- [Ru(NH3)4P(OEt)3NO](PF6)3 on V79 and rat hepatocyte cells. On hepatocyte culture values higher than 3.0 mM were determined for all tests, suggesting a low toxicity for the complex. For V79 cultures our results showed a similar cytotoxic effects for the three studied endpoints with an IC50 ranging around 2.0 mM, showing be less toxic than NaNP. The biotransformated product was evaluted and showed low toxicity for DNA, MTT assays and high toxicity for NRU, i.e., the compound biotransformed changed the lysosomal integrity. The acute toxicity was carried out and a LD50 value of 216 mg/Kg was obtained indicating a low toxicity in vivo.
Mestrado
Bioquimica
Mestre em Ciências Biológicas
DAELE, VERONIQUE. "Etudes cinetiques de reactions des radicaux libres d'interet atmospherique no#3, ch#3o, ch#3o#2, cl, clo." Paris 7, 1994. http://www.theses.fr/1994PA077018.
Full textJakobsson, Max, and Oscar Marklund. "Bränsleförbrukning i ett åkeri : En studie av åkeriers verksamhet avseende bränsleförbrukning & CO2-utsläpp." Thesis, Linnéuniversitetet, Institutionen för ekonomistyrning och logistik (ELO), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-86030.
Full textBackground & Problem: Transportation and distribution, such as 3PL, pose an essential part of a logistics company’s scope of duties; especially heavy transports, which account for a big part of the worldwide CO2-emissions, are an essential part of the business. Whilst fuel consumption makes up the majority of a company’s total consecutive expenses, it also augments carbon dioxide emission in our already flawed world. Therefore, the aim in the long run is a readjustment in the transport sector which includes the transition from fossil fuels towards renewable energy sources as well as the reduction of fuel consumption in general. This is also in the interest of the distribution companies, as they thereby can save expenses and reduce their ecological footprint at the same time. Yet, what determines the fuel consumption of a distribution company? To decry that, this study will primarily focus on eco-driving, route planning as well as technology as the main drivers of fuel consumption. It hereby is necessary to consider the chosen kind of fuel as an important factor regarding the CO2-emissions; this, however, will be analyzed separately. Purpose: The purpose of this paper is to study a selection distribution companies that primarily work on behalf of GDL, to examine which factors drive fuel consumption and CO2 emissions 6(95) within these companies. This papers ambition is to fairly evaluate the distribution companies and grade them accordingly, based on factors that drive fuel consumption and CO2 emissions. Additionally, this paper also aims to clarify the power structure between outsourcers, such as GDL, and their distributors. Method: This paper applies a positivistic scientific view with abduction as an approach. Based on this papers research questions it was determined that a qualitative research method should be applied throughout the study, with minor quantitative elements. Conclusions: The main factors for fuel consumption are parsimonious driving, route planning as well as technology. Hereby, frugal driving was ranked as the most important one as it can lead to a saving of 10-30 percent. Furthermore, the amount of used fuel can be positively influenced through the choice of certain fuel types. This has economical as well as ecological effects; the study focusses on renewable fuels, such as HVO, which has by far the lowest CO2- emissions amongst the fuels that were drawn into consideration. Influence by bigger actors, such as GDL, makes it hard to determine between different companies’ standings, as GDL’s position directly influences their smaller distributers.
Хамлика, П. П. "Світовий ринок логістичних послуг: тактика та стратегія діяльності суб'єктів ринку." Master's thesis, Сумський державний університет, 2019. http://essuir.sumdu.edu.ua/handle/123456789/75562.
Full textThe essence of strategic and tactical activity of the subjects of logistics market is investigated and the ways to improve the strategic planning system are investigated. The analysis of the main factors that influence the strategic planning of logistics activities. The main purpose of this study is to develop recommendations for improving the strategic and business planning system of logistics companies.
García, Olave Luis Vicente. "Análisis crítico del sistema excepcional de distribución de jornada de trabajo establecido en el artículo 38o." Tesis, Universidad de Chile, 2003. http://www.repositorio.uchile.cl/handle/2250/114592.
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El presente trabajo se enmarca dentro de la continua mutabilidad que presenta el Derecho del Trabajo, el que a través de sus diversas instituciones, va reflejando los constantes cambios que se van produciendo en nuestra vida social y económica. Nuestra legislación laboral ha debido ir adaptándose en su contenido a los nuevos requerimientos del sector productivo. La demanda por una mayor flexibilidad en la normativa sustantiva que regula las relaciones laborales se ha hecho cada vez más frecuente; y permanece vigente en nuestra comunidad nacional y jurídica la reflexión acerca de la conveniencia de introducir nuevas modificaciones a la legislación laboral. Centramos nuestro análisis sobre la flexibilidad en la jornada de trabajo y, particularmente, en el sistema excepcional establecido en el artículo 38 incisos penúltimo y final. Revisaremos la normativa sustantiva que la regula, lo dispuesto por la Dirección del Trabajo a través de sus órdenes de servicio o sus dictámenes y los Tribunales de Justicia, fallando una serie de recursos de protección. Esto, sin dejar de lado la doctrina nacional e internacional y las distintas realidades en el derecho comparado. El resultado de este trabajo, invita a reestudiar la normatividad existente incorporando la autonomía colectiva como fuente de flexibilización. La imposición heterónoma del Estado puede ceder paso, en el ámbito de las relaciones laborales, al reconocimiento de la empresa como fuente, y no solo objeto, de derecho. Tal descentralización de las fuentes del derecho del trabajo encuentra su fundamento en las necesidades productivas de las empresas y en que la actual identidad societal del trabajador se da a nivel de la empresa, como unidad de recepción y procesamiento de sus aspiraciones sociales. Todo esto, encontrando como límite el orden público laboral, aquél núcleo duro normativo insustituible en función de la seguridad y salud de los trabajadores.
丁群英 and Kwan-ying Winnis Ding. "Magnetic field decay of neutron star: effectsof interpinning of 3P2 neutron superfluid and 1S0 protonsuperconducting fluid." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1992. http://hub.hku.hk/bib/B31210764.
Full textMarchal, Frédéric. "Etude du transfert d'énergie dans les mélanges krypton-xénon depuis l'état moléculaire Kr2*[1u(3P1)] dissociatif." Toulouse 3, 1996. http://www.theses.fr/1996TOU30294.
Full textSharawe, Muhiyadin, and Sandeep Kumar. "SUPPLY CHAIN SUSTAINABILITY: : A case study about 3PL service providers’ environmental and social sustainability in Sweden." Thesis, Jönköping University, IHH, Företagsekonomi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-53845.
Full textHAYANI, BOUJEMAA. "Elaboration et etude magnetique des composes yba#2cu#3o#7#-# et yba#2(cu#1#-#xfe#x)#3o#7#-#." Paris 11, 1994. http://www.theses.fr/1994PA112267.
Full textMiškauskaitė, Jurgita. "Trečiųjų šalių logistikos paslaugos Lietuvoje." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2009~D_20140626_181822-31088.
Full textSUMMARY This Master‘s Thesis deals with logistics services and Third Party logistics partners, these services organization and performance. The aim of this Master Thesis is to analyse logistics services, Third Party logistics management and performance in Lithuania, to do the research in order to find out whether the Third Party logistics is sufficiently using or using at all in Lithuania. The tasks of this paper are as follows: to analyse the scientific literature on logistics services, also to identify Third Party logistics planning rules, to analyze the biggest Third Party logistics companies in Lithuania, to explain the research process and methods, to do the research, identifying whether the Third Party logistics sufficiently are using. and with reference to the literature analysed and the results received to present conclusions and recommendations. This Master‘s Thesis consists of introduction, theoretical part, practical part, research part, conclusions and suggestions. The theoretical parts deals with the analysis of logistics and 3PL logistics services. The practical part includes the analyzing the biggest 3PL providers in Lithuania. The research part is important to analyze the using of Third Party logistics in Lithuania. Conclusions confirm the hypothesis, i.e., The Third Party logistics is not popular in Lithuania.
Paulsson, Linda, Emelie Hjärtåker, and Lovisa Berg. "Social hållbarhet i tjänstekoncept : En studie om hur sju 3PL leverantörer förmedlar ansvarstagandet för social hållbarhet i sina hållbarhetsredovisningar." Thesis, Linnéuniversitetet, Institutionen för ekonomistyrning och logistik (ELO), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-55614.
Full textMcGarrie, David Robert. "How effective are 3PL & 4PL partnerships in the South African logistics supply chain / David Robert McGarrie." Thesis, North-West University, 2003. http://hdl.handle.net/10394/2425.
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