Relevant bibliographies by topics / 3D cellular structures

Academic literature on the topic '3D cellular structures'

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Published: 6 September 2023

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Journal articles on the topic "3D cellular structures"

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Liu, Ze, Wen Chen, Josephine Carstensen, Jittisa Ketkaew, Rodrigo Miguel Ojeda Mota, James K. Guest, and Jan Schroers. "3D metallic glass cellular structures." Acta Materialia 105 (February 2016): 35–43. http://dx.doi.org/10.1016/j.actamat.2015.11.057.

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Wang, Xin-Tao, Xiao-Wen Li, and Li Ma. "Interlocking assembled 3D auxetic cellular structures." Materials & Design 99 (June 2016): 467–76. http://dx.doi.org/10.1016/j.matdes.2016.03.088.

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Mandoc, Andrei Cristian, Raluca Lucia Maier, Constantin Gheorghe Opran, Vicenzo Delle Curti, and Giuseppe Lamanna. "BIOMIMETIC CELLULAR STRUCTURES FOR TURBINE SYSTEM COMPONENTS." International Journal of Modern Manufacturing Technologies 14, no. 2 (December 20, 2022): 151–58. http://dx.doi.org/10.54684/ijmmt.2022.14.2.151.

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The research aim is to investigate cellular structures inspired from nature, in order to improve the internal structural resistance of turbine system components (e.g. hydroelectric and gas turbine blades, OGV-Outer Guide Vanes, nacelles, gearboxes) with reduced mass. The investigations were conducted at laboratory level, utilizing two 3D printing technologies to acquire the desired cellular structures which were further tested for tensile, bending and impact resistance. The first selected technology was Fused Deposition Modelling with Continuous Filament Fabrication to obtain 3D printed parts, which can be reinforced with continuous carbon, glass, or Kevlar fibers. The second technology used is Digital Light Processing 3D printing, which uses photopolymer liquid resin that cures under digital light source. The main motivation of utilizing the 3D printing technologies is the desire of implementing rapid prototyping in the final manufacturing of the turbine system components with structural topological optimization and improved structural and dynamic efficiency through biomimetic inspired structures. Conventional polymeric composite manufacturing technologies are sometimes restrictive in the geometries they can produce, and there is a chance that additive manufacturing can step in and help create internal structures that could not be obtained through conventional manufacturing methods. New developed structural architectures could be manufactured for a specific application through 3D printing which allows for a high level of customization parameters, including the possibility to use continuous carbon, glass and Kevlar fiber to create the geometrical pattern. All these, combined with conventional composite manufacturing technologies, could lead to obtain better end results.
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Maibohm, Christian, Alberto Saldana-Lopez, Oscar F. Silvestre, and Jana B. Nieder. "3D Polymer Architectures for the Identification of Optimal Dimensions for Cellular Growth of 3D Cellular Models." Polymers 14, no. 19 (October 4, 2022): 4168. http://dx.doi.org/10.3390/polym14194168.

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Organ-on-chips and scaffolds for tissue engineering are vital assay tools for pre-clinical testing and prediction of human response to drugs and toxins, while providing an ethical sound replacement for animal testing. A success criterion for these models is the ability to have structural parameters for optimized performance. Here we show that two-photon polymerization fabrication can create 3D test platforms, where scaffold parameters can be directly analyzed by their effects on cell growth and movement. We design and fabricate a 3D grid structure, consisting of wall structures with niches of various dimensions for probing cell attachment and movement, while providing easy access for fluorescence imaging. The 3D structures are fabricated from bio-compatible polymer SZ2080 and subsequently seeded with A549 lung epithelia cells. The seeded structures are imaged with confocal microscopy, where spectral imaging with linear unmixing is used to separate auto-fluorescence scaffold contribution from the cell fluorescence. The volume of cellular material present in different sections of the structures is analyzed, to study the influence of structural parameters on cell distribution. Furthermore, time-lapse studies are performed to map the relation between scaffold parameters and cell movement. In the future, this kind of differentiated 3D growth platform, could be applied for optimized culture growth, cell differentiation, and advanced cell therapies.
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Zhao, Jiayu, Seongkyu Song, Xuan Mu, Soon Moon Jeong, and Jinhye Bae. "Programming mechanoluminescent behaviors of 3D printed cellular structures." Nano Energy 103 (December 2022): 107825. http://dx.doi.org/10.1016/j.nanoen.2022.107825.

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Kucewicz, Michał, Paweł Baranowski, Jerzy Małachowski, Arkadiusz Popławski, and Paweł Płatek. "Modelling, and characterization of 3D printed cellular structures." Materials & Design 142 (March 2018): 177–89. http://dx.doi.org/10.1016/j.matdes.2018.01.028.

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Limmahakhun, Sakkadech, Adekunle Oloyede, Kriskrai Sitthiseripratip, Yin Xiao, and Cheng Yan. "3D-printed cellular structures for bone biomimetic implants." Additive Manufacturing 15 (May 2017): 93–101. http://dx.doi.org/10.1016/j.addma.2017.03.010.

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Mishriki, Sarah, Srivatsa Aithal, Tamaghna Gupta, Rakesh P. Sahu, Fei Geng, and Ishwar K. Puri. "Fibroblasts Accelerate Formation and Improve Reproducibility of 3D Cellular Structures Printed with Magnetic Assistance." Research 2020 (July 23, 2020): 1–15. http://dx.doi.org/10.34133/2020/3970530.

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Fibroblasts (mouse, NIH/3T3) are combined with MDA-MB-231 cells to accelerate the formation and improve the reproducibility of 3D cellular structures printed with magnetic assistance. Fibroblasts and MDA-MB-231 cells are cocultured to produce 12.5 : 87.5, 25 : 75, and 50 : 50 total population mixtures. These mixtures are suspended in a cell medium containing a paramagnetic salt, Gd-DTPA, which increases the magnetic susceptibility of the medium with respect to the cells. A 3D monotypic MDA-MB-231 cellular structure is printed within 24 hours with magnetic assistance, whereas it takes 48 hours to form a similar structure through gravitational settling alone. The maximum projected areas and circularities, and cellular ATP levels of the printed structures are measured for 336 hours. Increasing the relative amounts of the fibroblasts mixed with the MDA-MB-231 cells decreases the time taken to form the structures and improves their reproducibility. Structures produced through gravitational settling have larger maximum projected areas and cellular ATP, but are deemed less reproducible. The distribution of individual cell lines in the cocultured 3D cellular structures shows that printing with magnetic assistance yields 3D cellular structures that resemble in vivo tumors more closely than those formed through gravitational settling. The results validate our hypothesis that (1) fibroblasts act as a “glue” that supports the formation of 3D cellular structures, and (2) the structures are produced more rapidly and with greater reproducibility with magnetically assisted printing than through gravitational settling alone. Printing of 3D cellular structures with magnetic assistance has applications relevant to drug discovery, lab-on-chip devices, and tissue engineering.
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Zhao, Weiming, Cao Wang, and Zhe Zhao. "Bending Strength of 3D-Printed Zirconia Ceramic Cellular Structures." IOP Conference Series: Materials Science and Engineering 678 (November 27, 2019): 012019. http://dx.doi.org/10.1088/1757-899x/678/1/012019.

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Oh, Min Jun, and Pil J. Yoo. "Graphene-based 3D lightweight cellular structures: Synthesis and applications." Korean Journal of Chemical Engineering 37, no. 2 (January 30, 2020): 189–208. http://dx.doi.org/10.1007/s11814-019-0437-1.

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Dissertations / Theses on the topic "3D cellular structures"

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Sangle, Sagar Dilip. "Design and Testing of Scalable 3D-Printed Cellular Structures Optimized for Energy Absorption." Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright1495467365594915.

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Chu, Chen. "Design synthesis for morphing 3D meso-scale structure." Thesis, Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/34676.

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Rapid prototyping (RP) can be used to make complex shapes with very little or even no constraint on the form of the parts. New design methods are needed for parts that can take advantage of the unique capabilities of RP. Although current synthesis methods can successfully solve simple design problems, practical applications with thousands to millions elements are prohibitive to generate solution for. Two factors are considered. One is the number of design variables; the other is the optimization method. To reduce the number of design variables, parametric approach is introduced. Control diameters are used to control all strut size across the entire structure by utilizing a concept similar to control vertices and Bezier surface. This operation allows the number of design variables to change from the number of elements to a small set of coefficients. In lattice structure design, global optimization methods are popular and widely used. These methods use heuristic strategies to search the design space and thus perform, as oppose to traditional mathematical programming (MP) methods, a better global search. This work propose that although traditional MP methods find local optimum near starting point, given a quick convergence rate, it will be more efficient to perform such method multiple times to integrate global search than using a global optimization method. Particle Swarm Optimization and Levenburg-Marquardt are chosen to perform the experiments.
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Goel, Archak. "Design of Functionally Graded BCC Type Lattice Structures Using B-spline Surfaces for Additive Manufacturing." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1552398559313737.

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Jorapur, Nikhil Sudhindrarao. "Design, Fabrication and Testing of Fiber-Reinforced Cellular Structures with Tensegrity Behavior using 3D Printed Sand Molds." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/84531.

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The overall goal of this work is to improve the structural performance of cellular structures in bending applications by incorporating tensegrity behavior using long continuous fibers. The designs are inspired by the hierarchical cellular structure composition present in pomelo fruit and the structural behavior of tensegrity structures. A design method for analyzing and predicting the behavior of the structures is presented. A novel manufacturing method is developed to produce the cellular structures with tensegrity behavior through the combination additive manufacturing and metal casting techniques. Tensegrity structures provide high stiffness to mass ratio with all the comprising elements experiencing either tension or compression. This research investigates the possibility of integrating tensegrity behavior with cellular structure mechanics and provides a design procedure in this process. The placement of fibers in an octet cellular structure was determined such that tensegrity behavior was achieved. Furthermore, using finite element analysis the bending performance was evaluated and the influence of fibers was measured using the models. The overall decrease in bending stress was 66.6 %. Extending this analysis, a design strategy was established to help designers in selecting fiber diameter based on the dimensions and material properties such that the deflection of the overall structure can be controlled. This research looks to Additive Manufacturing (AM) as a means to introduce tensegrity behavior in cellular structures. By combining Binder Jetting and metal casting a controlled reliable process is shown to produce aluminum octet-cellular structures with embedded fibers. 3D-printed sand molds embedded with long continuous fibers were used for metal casting. The fabricated structures were then subjected to 4 point bending tests to evaluate the effects of tensegrity behavior on the cellular mechanics. Through this fabrication and testing process, this work addresses the gap of evaluating the performance of tensegrity behavior. The overall strength increase by 30%. The simulation and experimental results were then compared to show the predictability of this process with errors of 2% for octet structures without fibers and 6% for octet structures with fibers.
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Carozzani, Tommy. "Développement d'un modèle 3D Automate Cellulaire-Éléments Finis (CAFE) parallèle pour la prédiction de structures de grains lors de la solidification d'alliages métalliques." Phd thesis, Ecole Nationale Supérieure des Mines de Paris, 2012. http://pastel.archives-ouvertes.fr/pastel-00803282.

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La formation de la structure de grains dans les métaux pendant la solidification est déterminante pour les propriétés mécaniques et électroniques des pièces coulées. En plus de la texture donnée au matériau, la germination et la croissance des grains sont liées en particulier avec la formation des phases thermodynamiques et les inhomogénéités en composition d'éléments d'alliage. La structure de grains est rarement modélisée à l'échelle macroscopique, d'autant plus que l'approximation 2D est très souvent injustifiée. Dans ces travaux, la germination et la croissance de chaque grain individuel sont suivies avec un modèle macroscopique 3D CAFE. La microstructure interne des grains n'est pas explicitement résolue. Pour valider les approximations faites sur cette microstructure, une comparaison directe avec un modèle microscopique "champ de phase" a été réalisée. Celle-ci a permis de valider les hypothèses de construction du modèle CAFE, de mettre en avant le lien entre données calculées par les modèles microscopiques et paramètres d'entrée des modèles à plus grande échelle, et les domaines de validité de chaque modèle. Dans un deuxième temps, un couplage avec la ségrégation chimique et les bases de données thermodynamiques a été mise en place et appliquée sur un alliage binaire étain-plomb. Une expérience de macroségrégation par convection naturelle a été simulée. L'accord entre les courbes de température expérimentales et simulées atteint une précision de l'ordre de 1K, et la recalescence est correctement prédite. Les cartes de compositions sont comparables qualitativement, ainsi que la structure de grains. Les avantages du suivi de la structure ont été mis en évidence par rapport à une simulation par éléments finis classique. De plus, il a été montré que le calcul 3D était ici indispensable. Enfin, une implémentation parallèle optimisée du code a permis d'appliquer le modèle CAFE à un lingot de silicium polycristallin industriel de dimensions 0,192 x 0,192 x 2,08m, avec une taille de cellules de 250µm. Au total, 4,9 milliards de cellules sont représentées sur le domaine, et la germination et la croissance de 1,6 million de grains sont suivies.
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Pineau, Adrian. "Modélisation 3D de structures de grains par une approche automate cellulaire. Application à la compétition de croissance dendritique et à la cristallisation du silicium polycristallin." Thesis, Paris Sciences et Lettres (ComUE), 2019. http://www.theses.fr/2019PSLEM042.

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Les structures de grains résultantes des procédés de solidification influencent fortement les propriétés d'une pièce industrielle. Ceci est notamment le cas pour les propriétés mécaniques des pièces de fonderie en alliage métallique, ou les propriétés électriques des cellules photovoltaïque de silicium. L'approche CA-FE (Cellular Automaton - Finite Elements) permet de modéliser l'évolution des structures de grains dans les procédés de solidification à l'échelle macroscopique, mais nécessite des approximations aux échelles plus fines. Dans ce travail deux axes d'étude sont proposés. Premièrement, des simulations CA de compétition de croissance entre grains colonnaires sont réalisées pour un alliage de succinonitrile-0,4%pds acétone. Ceci est effectué en déterminant l'angle de joint grains en solidification dirigé. Ce travail est comparé à une étude champ de phase visant à étudier la relation entre orientations cristallographiques des grains en compétition et orientation de leur frontière. Les résultats obtenus avec l'approche CA sont très proches des résultats champ de phase pour un intervalle de taille de cellule centré autour de la marche maximale entre deux pointes de dendrites stationnaires de deux grains en compétition. La configuration d'Esaka, correspondant à une compétition de croissance dans un alliage de succinonitrile-1,3%pds acétone, a aussi été étudiée par l'approche CA. Le travail sur la croissance du silicium polycristallin a été réalisé dans le cadre du projet ANR CrySaLID. La méthode CA a été enrichie afin de permettre la modélisation de la croissance d'interfaces facettées et de la germination de grains en relation de macle sur ces interfaces. Ces développement utilisent des approches géométriques qui se basent sur des observations expérimentales in situ et ex situ. Le modèle résultant a été confronté expérimentalement et donne de bons accords qualitatif et quantitatif. Finalement, le modèle est appliqué à un cube de dimensions centimétriques. Il a été montré que les spécificités liées à la croissance du silicium polycristallin, à savoir la formation de facettes et la germination de grains en relation de macle, modifient drastiquement la structure de grains en comparaison avec une microstructure dendritique
Grains structures obtained during solidification processes strongly influence the properties of technical products. It is specially the case for cast parts in metallic alloys, or for silicon photovoltaic cells. The CA-FE (Cellular Automaton - Finite Elements) method aims to model grain structure evolution during solidification at a macroscopic scale, but also requires approximations at smaller scales. In this work, two distinct studies are proposed. First, CA simulations of growth competition among columnar dendritic grains are carried out for a succinonitrile-0.4 wt% acetone alloy. This is achieved by computing the grain goundary orientation during directional solidification. Comparisons are subsequently conducted with recent phase field results derived under the same conditions. An excellent agreement is found with phase field simulations results within arange of intermediate cell size centered around the maximum step between primary stationary dendrite tips of the two competing grains. The Esaka configuration, corresponding to a dendritic growth competition for a succinonitrile-1.3 wt% acetone alloy, is also studied. Polycristalline silicon growth was investigated within the ANR CrySaLID project. The CA method was enriched to allow facets growth and grains in twin relationship modeling. These developements use a geometrical approach based on in situ and ex situ experimental observations. The resulting numerical model was applied to experimental configurations and good qualitative and quantitative agreements were found. Simulations over a cubic and centimetric domain were lastly conducted. It was found that facets growth and twin nucleations strongly modify the grains structure compared to a dendritic microstructrure
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Baux, Anthony. "Synthèse de matériaux alvéolaires base carbures par transformation d'architectures carbonées ou céramiques par RCVD/CVD : application aux récepteurs solaires volumiques." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0193/document.

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L’objectif était de concevoir et réaliser des architectures alvéolaires performantes pour les récepteurs solaires volumétriques des futures centrales thermodynamiques. Trois stratégies différentes sont envisagées pour l’ébauche des préformes carbones ou céramiques : (i) la synthèse de matériaux biomorphiques issus de la découpe de balsa, (ii) l’élaboration de structures céramiques par projection de liant et (iii) la réplication de structures polymères réalisées par impression 3D, à l’aide d’une résine précurseur de carbone ou céramique. Dans tous les cas, les préformes crues sont converties par pyrolyse en C ou SiC et une étape d’infiltration/revêtement de SiC par CVD (Chemical Vapor Deposition) achève la fabrication des structures céramiques. Une étape intermédiaire de RCVD (Reactive CVD) a été mise en œuvre au cours de la première voie, afin de convertir la structure carbonée microporeuse en TiC. La composition, la microstructure et l’architecture poreuse des structures céramiques ont tout d’abord été caractérisées. Les caractéristiques des matériaux les plus pertinentes, compte tenu de l’application en tant qu’absorbeur solaire, ont ensuite été examinées. Les propriétés thermomécaniques et la résistance à l’oxydation ont ainsi été caractérisées en priorité. La perméabilité et les propriétés thermo-radiatives, qui sont également deux facteurs importants pour l’application, ont également été considérées
The aim is to design and create efficient cellular architectures for volumetric solar receivers used in the future thermodynamic power plants. Three strategies are considered for the creation of ceramic or carbon preforms: (i) the synthesis of biomorphic materials resulting from the cutting of balsa, (ii) the elaboration of ceramic structures by binder jetting and (iii) the replication of polymer structures made by 3D printing, using a carbon or ceramic precursor resin. In all cases, the green preforms are converted by pyrolysis to C or SiC and an infiltration step / SiC coating by CVD (Chemical Vapor Deposition) completes the manufacture of ceramic structures. An intermediate stage of RCVD (Reactive CVD) was implemented during the first strategy, in order to convert the microporous carbonaceous structure into TiC. The composition, the microstructure and the porous architecture of the ceramic structures were first characterized. The characteristics of the most relevant materials, considering the application as a solar receiver, were then examined. The thermomechanical properties and the oxidation resistance have thus been characterized in priority. Permeability and thermo-radiative properties, which are also two important factors for application, were also considered
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Bresteau, Enzo. "Adhesive Clathrin Structures Support 3D Haptotaxis Through Local Force Transmission." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS546.

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La migration cellulaire est un processus fondamental au maintien des fonctions physiologiques de l’organisme. Elle est également centrale dans de nombreuses pathologies et entre notamment en jeu lors de la dissémination métastatique. Lorsqu’elles migrent, les cellules utilisent des structures d’adhésion afin de s’appuyer sur leur environnement. Nous avons récemment montré que les puits recouverts de clathrine, plus connus pour leur rôle dans l’endocytose, peuvent également servir de structures d’adhésion. Dans ce manuscrit, je démontre que certains ligands internalisés par la voie d’endocytose clathrine peuvent également se lier à la matrice et orienter la migration cellulaire en régulant les structures adhésives de clathrine.J’ai commencé par montrer que le collagène est associé à plus de structures de clathrine et a plus de protrusions lorsqu’il est recouvert par des ligands. J’ai ensuite montré que les cellules appliquaient plus de forces sur des fibres de collagènes décorées par des ligands et que ce surplus de force nécessite la présence de structures de clathrine. Enfin j’ai montré que les cellules suivent les ligands liés à des réseaux de collagène en 3D et que cette migration dirigée nécessite également la présence de structures de clathrine. Ce mécanisme de migration pourrait notamment permettre aux cellules de suivre des gradients de ligands liés à la matrice in vivo et ainsi de s’orienter dans l’organisme
Cell migration is a fundamental process in the development and homeostasis of multicellular organisms. It is also central to many pathologies and it is especially important for metastatic dissemination. When migrating, cells use adhesion structures to push on their substrate in order to move forward. We recently showed that clathrin coated structures, primarily known as endocytic structures, can also serve as adhesion structures. In this manuscript, I show that some ligands internalized through clathrin mediated endocytosis can also bind to the extracellular matrix and orient cell migration using adhesive clathrin structures.I first showed that ligand-decorated collagen fibers are associated with more clathrin structures and more protrusions. I then showed that cells applied more forces to the ligand-decorated collagen fibers and this extra amount of forces requires the presence of clathrin structures. Finally, I showed that cells can migrate following collagen-bound ligands in 3D, this directed migration also requiring the presence of clathrin structures. Such migration mechanism could be used by cells to follow in vivo gradient of matrix-bound ligands and thus find their way when migrating inside the body
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Pietrzyk-Nivau, Audrey. "Génération de plaquettes in vitro à partir de cellules souches hématopoïétiques." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05P626/document.

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La mégacaryopoïèse représente le processus de différenciation des cellules souches hématopoïétiques (CSH) en mégacaryocytes (MK). Ce processus précède la thrombopoïèse qui aboutira à la formation des plaquettes sanguines. Ces processus complexes ont lieu 1) au sein de la structure tridimensionnelle (3D) de la moelle osseuse, 2) dans les vaisseaux sinusoïdes de la moelle et 3) dans la circulation sanguine. Le but général de ce travail a été de comprendre le mécanisme de chaque étape. Le premier objectif a été d’étudier les effets d’une structure poreuse 3D mimant celle de la moelle osseuse, sur la différenciation mégacaryocytaire et la production plaquettaire in vitro. Cette étude a permis de démontrer que la synergie entre l’organisation spatiale et les signaux du microenvironnement améliore la production en MK et en plaquettes. Par la suite, nous avons souhaité caractériser in vitro et in vivo les plaquettes produites en conditions de flux. Nous avons notamment mis en évidence la capacité des plaquettes produites in vitro dans un système de microfluidique, à s’incorporer et à participer à la formation d’un thrombus in vitro et in vivo contrairement aux plaquettes obtenues en statique. Ces travaux prouvent donc l’intérêt d’une part, de mimer le microenvironnement de la moelle osseuse et d’autre part, de reproduire les forces de cisaillement du sang afin d’améliorer et d’augmenter la production de plaquettes in vitro pour de futures applications en thérapeutique
Megakaryopoiesis is a process allowing hematopoietic stem cell (HSC) to proliferate and differentiate into megakaryocytes (MK). It is followed by thrombopoiesis allowing blood platelet production. These processes occur 1) in the bone marrow three-dimensional (3D) structure, 2) in the bone marrow sinusoid vessels and 3) in the blood flow. Our general aim was to decipher the mechanism associated to each process. The first objective was to study the effects of porous 3D structure on MK differentiation and platelet production. This study demonstrated that the synergy between spatial organization and biological cues improved MK and platelet production. We also characterized platelets produced from mature MK in flow conditions, with respect to their in vitro and in vivo properties. We highlighted the capacity of flow-derived platelets to incorporate in a thrombus in vitro and in vivo, compared to static-derived platelets. These works represent some new developments for mimicking the bone marrow structure and to reproduce blood shear forces in order to improve and increase in vitro platelet production for therapeutic use
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UREÑA, MARTÍN Carlos. "Study of Caveolae Mechanotransduction Under 3D Compressive Stresses : Comparative Analysis of 2 Models Mimicking Structural and Mechanical Tumor Characteristics." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS525.

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La mécanique et le stress compressif jouent un rôle important dans la progression tumorale. Récemment, plusieurs approches ont été développées pour tester le stress en compression dans des modèles 3D in vitro. Dans le présent travail, nous montrons d’abord la pertinence de la compression dans l’organisation des fibroblastes associés au cancer (CAF), en enveloppant les cellules cancéreuses lors d’une compression isotrope 3D dans des capsules d’alginate creux. Dans ce système, les CAF couvrent les cellules cancéreuses en présence de compression selon un processus impliquant vraisemblablement une réorganisation du dépôt de fibronectine et non un réarrangement passif des deux sphéroïdes. Dans la deuxième partie de ce travail, nous avons étudié la réaction des composants de la cavéole au stress en compression.Les cavéoles sont des invaginations de la membrane plasmique capables d'amortir la tension de la membrane, protégeant ainsi la cellule de son éclatement. Nous montrons ici comment les cavéoles réduisent leur présence lors de la compression3D à court terme et comment cette compression inhibe l'activation de STAT1 et STAT3 induite par l'interféron. De plus, les effets à long terme des contraintes de compression sur les sphéroïdes entraînent également la perte du composant cavéole EHD2, une ATPase centrale pour la stabilité des cavéoles sur la membrane. Enfin, nous avons trouvé différentes voies avec une transcription modifiée du gène après un stress compressif. Parmi eux, nous avons caractérisé l'effet de la perte decavéoline-1 sur la libération d'exosomes sous compression 3D
Mechanics and compressive stress play an important role in tumor progression. Recently, several approaches have been developed to test compressive stress in 3D in vitro models. In the present work, we first show the relevance of compression in the organization of cancer associated fibroblasts (CAFs), enwrapping cancer cells upon 3D isotropic compression in capsules of hollow alginate. In this system, CAFs cover cancer cells in the presence of compression by a process which most likely involves fibronectin deposition reorganization, and not a passive rearrangement of the two spheroids. In the second part of this work, we investigated the response of caveolae components to compressive stress. Caveolae are plasma membrane invaginations which are able to buffer membrane tension, thus protecting the cell from bursting. Here, we show how caveolae reduce their presence under 3D short term compression, and how this compression inhibits interferon induced STAT1 and STAT3 activation. Moreover, long term effects of compressive stress in spheroids result also in loss of the caveolae component EHD2, acentral ATPase for caveolae stability on the membrane. Lastly, we found different pathways with altered gene transcription after compressive stress. Among them, we characterized the effect of caveolin-1 loss on the release of exosomes under 3Dcompression
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Book chapters on the topic "3D cellular structures"

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Markova, V., and S. Piskunov. "Computer models of 3D cellular structures." In Lecture Notes in Computer Science, 70–84. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/3-540-60222-4_98.

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Fukuda, Toshio, Tao Yue, Masaru Takeuchi, and Masahiro Nakajima. "On-Chip Fabrication, Manipulation and Self-Assembly for Three-Dimensional Cell Structures." In Hyper Bio Assembler for 3D Cellular Systems, 151–76. Tokyo: Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-55297-0_9.

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Zhu, Xiaolu, and Zheng Wang. "Constructing 3D Tissue Structures via Cellular Self-Assembly at Patterned Interfaces inside Hydrogel." In Self-Organized 3D Tissue Patterns, 59–75. New York: Jenny Stanford Publishing, 2022. http://dx.doi.org/10.1201/9781003180395-4.

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Gupta, Vijendra, Addis Kidane, and Michael Sutton. "Density-Graded 3D Voronoi Cellular Structures for Improved Impact Performance." In Dynamic Behavior of Materials, Volume 1, 123–28. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-17453-7_18.

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Ben Ali, N., D. Hammami, M. Khlif, and C. Bradai. "3D Printed Cellular Structures of PLA for Engineering Artificial Bone." In Advances in Mechanical Engineering and Mechanics II, 27–33. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-86446-0_4.

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Brandstetter, Andrea, Najoua Bolakhrif, Christian Schiffer, Timo Dickscheid, Hartmut Mohlberg, and Katrin Amunts. "Deep Learning-Supported Cytoarchitectonic Mapping of the Human Lateral Geniculate Body in the BigBrain." In Lecture Notes in Computer Science, 22–32. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-82427-3_2.

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AbstractThe human lateral geniculate body (LGB) with its six sickle shaped layers (lam) represents the principal thalamic relay nucleus for the visual system. Cytoarchitectonic analysis serves as the groundtruth for multimodal approaches and studies exploring its function. This technique, however, requires experienced knowledge about human neuroanatomy and is costly in terms of time. Here we mapped the six layers of the LGB manually in serial, histological sections of the BigBrain, a high-resolution model of the human brain, whereby their extent was manually labeled in every 30th section in both hemispheres. These maps were then used to train a deep learning algorithm in order to predict the borders on sections in-between these sections. These delineations needed to be performed in 1 µm scans of the tissue sections, for which no exact cross-section alignment is available. Due to the size and number of analyzed sections, this requires to employ high-performance computing. Based on the serial section delineations, high-resolution 3D reconstruction was performed at 20 µm isotropic resolution of the BigBrain model. The 3D reconstruction shows the shape of the human LGB and its sublayers for the first time at cellular precision. It represents a use case to study other complex structures, to visualize their shape and relationship to neighboring structures. Finally, our results could provide reference data of the LGB for modeling and simulation to investigate the dynamics of signal transduction in the visual system.
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Zhu, Xiaolu, and Zheng Wang. "Tuning Cellular Behaviors during Self-Organization of Cells in Hydrogel by Changing Inner Nano-Structure of Hydrogel." In Self-Organized 3D Tissue Patterns, 95–130. New York: Jenny Stanford Publishing, 2022. http://dx.doi.org/10.1201/9781003180395-6.

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Alkentar, Rashwan, Dávid Huri, and Tamás Mankovits. "Numerical Investigation of 3D Lattice Infill Pattern Cellular Structure for Orthopedic Implant Design." In Machine and Industrial Design in Mechanical Engineering, 467–72. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-88465-9_45.

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Rajwar, Anjali, Payal Vaswani, A. Hema Naveena, and Dhiraj Bhatia. "Designer 3D-DNA nanodevices: Structures, functions, and cellular applications." In Advances in Protein Molecular and Structural Biology Methods, 669–76. Elsevier, 2022. http://dx.doi.org/10.1016/b978-0-323-90264-9.00040-4.

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Dong, Guoying, Yunlong Tang, and Yaoyao Fiona Zhao. "Mesoscale Lattice Structure Design and Simulation with the Support of a Property Database." In Advances in Computers and Information in Engineering Research, Volume 2, 247–73. ASME, 2021. http://dx.doi.org/10.1115/1.862025_ch8.

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The lattice structure is a type of cellular materials [1] that has truss-like structures with interconnected struts and nodes in a three-dimensional (3D) space. Compared to other cellular materials such as random foams and honeycombs, the lattice structures exhibit better mechanical performance [2]. Some examples of lattice structures are shown in Figure 8.1. The first one is a randomized lattice structure. Due to the disordered lattice cells, the properties of this type of lattice structures are stochastic and difficult to control. But it can be used as implants in orthopedic surgeries. The second and the third are lattice structures with periodic unit cells. The difference is that the strut thickness of the second one is uniform, which is called homogeneous lattice structures. However, the third one has non-uniform strut thickness for specific loading conditions, which is called heterogeneous lattice structures. By properly adjusting the material in vital parts of the lattice structure, the heterogeneous periodic lattice structure can have a better mechanical performance than the homogeneous one with the same weight. Plenty of design and optimization methods [3-5] have been proposed for lattice structures to pursue better performance in different engineering applications. For example, the lattice structure is applied to achieve lightweight [3, 4], energy absorption [6], and thermal management [7]. Due to the complexity of the geometry, the fabrication of lattice structures had been the most critical issue. However, with the development of Additive Manufacturing (AM) processes, the difficulty in the fabrication was largely relieved.
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Conference papers on the topic "3D cellular structures"

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Berretti, S., A. Del Bimbo, and P. Pala. "Content based retrieval of 3D cellular structures." In IEEE International Conference on Multimedia and Expo, 2001. ICME 2001. IEEE, 2001. http://dx.doi.org/10.1109/icme.2001.1237865.

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Rastegarzadeh, Sina, Samuel Muthusamy, and Jida Huang. "Mechanical Profile and 3D Printability of Cellular Structures." In ASME 2022 17th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/msec2022-85541.

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Abstract Microstructures are critical elements for mechanical metamaterials design and fabrication. Tailoring the internal microscale structural pattern can achieve a much broader range of bulk properties than the constituent materials, thus enabling the metamaterial design with extraordinary properties. Studying the mechanical properties and fabricability of microstructures is critical for understanding metamaterials’ structural design and macroscale performances. This paper categorizes the commonly designed microstructures into two main classes: deterministic implicit function-based and stochastic nature-based designing strategies. The mechanical properties and 3D printability of typical instances within the two classes are studied and experimentally analyzed. Specifically, we investigate the macroscale mechanical properties (e.g., Young’s modulus, shear modulus, bulk modulus, percentage of anisotropy) of microstructures defined with triply periodic minimal surfaces (TPMS), Fourier series-based functions (FSFs), Gaussian random filed-based (GRF), and Voronoi-based microstructures. Asymptotic homogenization is exploited herein to study the macroscale properties of different microstructures, and the manufacturability of the structures is experimentally analyzed and validated on an FDM printer. We summarize the mechanical profiles and manufacturability of these microstructures defined by various principles. The resulting mechanical profiles and manufacturability of microstructures provide a reasonable basis for establishing a microstructure database and shed light on the on-demand structural units generation for metamaterial design and fabrication.
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Djokikj, Jelena, and Jovana Jovanova. "DfAM of Nonlinear Cellular Flexible Structures." In ASME 2019 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/smasis2019-5673.

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Abstract Nonlinear cellular structures are defined as structures with multiple scale unit cells patterned through the volume of the structure. The geometrical nonlinearity allows local high flexibility in the movement and also in the sense of strength of materials. The focus of this paper is to create a framework for design for additive manufacturing (DfAM) of a modular nonlinear cellular structure with high level of flexibility. The flexibility will be exploited in skin-like structures adaptable to freeform geometries or utilize flat printed designs for voluminous and structural 3D shapes. For the modeling of the structure CAD software is used and for the fabrication of the structure additive manufacturing (AM) is applied. These technologies work by adding the material in layers, which enables fabrication of parts with complex geometries. The working principal of AM which is opposite to the traditional manufacturing requires for changes in the design process. These changes are applied in the DfAM that we are presenting with this study. The DfAM is used to develop a systematic design approach to support the fabrication of unique structure shapes by AM.
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Kravcov, Alexander N., Pawel Platek, Wojciech Koperski, and Vaclav Pospichal. "Internal Structure Research of 3D Printed Cellular Structures by Laser-ultrasonic Structuroscopy." In 2019 International Conference on Military Technologies (ICMT). IEEE, 2019. http://dx.doi.org/10.1109/miltechs.2019.8870047.

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Perelman, Binjamin, and Vishal S. Sharma. "Assessing the Mechanical Properties of 3D Printed Bio-Inspired Structures and Integrating Them Into a Product." In ASME 2021 16th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/msec2021-60675.

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Abstract The Honeycomb structure is one of the most common natural structures used in sandwich panel cores. The Enamel structure’s mechanical properties were compared to the Honeycomb structure’s mechanical properties to investigate if the Enamel structure can improve the compressive strength, stiffness and energy absorption capabilities of sandwich panel cores and potentially replace the common Honeycomb structure. Also, the optimal cellular configurations for the Honeycomb and Enamel structures were explored. Indeed, it was found the Enamel structure can potentially replace the Honeycomb structure and a wall thickness of 1.2 mm and a wall length/cell radius of 8.14 mm will maximize the natural structures mechanical properties. Furthermore, it was found that both the natural structures have good compressive strength. Therefore, the natural structures with their optimal cellular configurations were integrated into a novel automobile floor mat to ensure the mat possesses good compressive strength to resist failure or permanent deformation. Moreover, the novel automobile floor mat has a design feature that offers an efficient debris capturing and removal system that adds value to the automobile floor mat.
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Jiang, Yunyao, and Yaning Li. "Optimal Sinusoidal Cellular Structures for Energy Absorption." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-66824.

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In this investigation, the elastic mechanical properties of the sinusoidal cellular structures were first explored via analytical models. The analytical analysis showed that for linear elastic materials, the amplitude-to-wavelength ratio of the sinusoidal structures is a key geometric parameter to determine the deformation mechanisms. To further evaluate the influences of the geometric nonlinearity, a set of finite element simulations were performed for sinusoidal structures with the same density but various amplitude-to-wavelength ratios. It was found that the optimal amplitude-to-wavelength ratio for the maximum energy absorption corresponds to the transition between symmetric to asymmetric deformation mechanisms. Selected designs were fabricated via a 3D printer (Objet, Connex 260). Mechanical experiments under quasi-static uniaxial compression and cyclic compression were performed on the 3D printed specimens. Finite element (FE) simulations with both linear elastic and nonlinear hyperelastic material models were performed and compared with the experiments. The 3D-printed sinusoidal structures were shown to be re-configurable under cyclic loading.
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Bandi, Punit, Andres Tovar, and John Renaud. "Design of 2D and 3D Non-linear Compliant Mechanisms using Hybrid Cellular Automata." In 52nd AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics and Materials Conference. Reston, Virigina: American Institute of Aeronautics and Astronautics, 2011. http://dx.doi.org/10.2514/6.2011-1835.

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Kang, Ye, Kwangwon Kim, and Jaehyung Ju. "Reconfigurable Compliant Cellular Material With Programmable Compliant Cellular Structure." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-52572.

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Cellular materials have two important properties: structures and mechanisms. This property enables one to design structures with proper stiffness and flexibility. Recent advance in 3D printing technologies enable engineers to manufacture complex cellular structures. In addition, use of smart materials, e.g., shape memory polymers (SMPs), for 3D printing enables us to construct mesostructures actively responsive to environmental stimuli with a programmable function, which may be termed ‘4D Printing’ referring to additional dimension on time-dependent shape change after 3D printing. The objective of this study is to design and synthesize active reconfigurable cellular materials, which enables the advance of technology on intelligent reconfigurable cellular structures with 4D printing. A two-layer hinge of a CPS functions through a programmed thermal expansion mismatch between two layers and shape memory effect of an SMP. Starting with thermo-mechanical constitutive modeling of a compliant porous hinge consisting of laminated elastomer composites, macroscopic behaviors of a reconfigurable compliant porous structure (CPS) will be constructed using the strain energy method. A finite element (FE) based simulation equipped with a user subroutine will be implemented with ABAQUS/Standard to simulate time-dependent thermo mechanical behaviors of a CPS. The designed CPS with polymers shows an extremely high negative Poisson’s ratio (∼ −120) and negative thermal expansion coefficient (−2,530 × 10−6/C). When programmed with an appropriate thermo-mechanical procedure, the hinge of the CPS bends either in positive and negative sign, which enables to tailor the CPS into desired intermediate and final configurations, ending up with achieving a reconfigurable CPS. This paper demonstrates that actively reconfigurable compliant cellular materials (CCMs) with CPSes can be used for next-generation materials design in terms of tailoring mechanical properties such as modulus, strength, yield strain, Poisson’s ratios and thermal expansion coefficient together with programmable characteristics.
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Chakraborty, Souvik, Dylan Hebert, and Tanvir Rahman Faisal. "Variations of In-Plane Mechanical Properties of Cellular Structures With Different Hierarchical Organizations." In ASME 2020 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/imece2020-24050.

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Abstract Inspired by the nature, this study analyzes in-plane compressive responses of different modes of hierarchical architected structures with varying topologies. Architected cellular structures with two different unit cell topologies — square and kagome are considered, both having a relative density of 0.25. Each unit cell topology is designed with three different configurations. The base structure is the primitive one with solid homogeneous cell wall. The nested hierarchical structure is derived from the primitive one with cellular structuring in the cell wall. The third and final one is the fractal-like hierarchical structure, where same unit cells appear on different length scales. 3D printed structures were subjected to uniaxial compression to characterize their in-plane mechanical properties. The compressive stress-strain behaviors reveal that all the structures demonstrate the classical behavior of cellular structures followed by significant recovery of their initial shape upon load withdrawal. The energy absorptions demonstrated by the plateau regions before densification are not only governed by their structural topologies, but also largely governed by the configurations of hierarchical organizations. Hence, this study suggests the application specific design of hierarchical architected structures for defined loading conditions.
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A. Froyland, L., A. Laksa, K. Strom, and J. Pajchel. "A 3D cellular, smooth boundary representation modelling system for geological structures." In 55th EAEG Meeting. European Association of Geoscientists & Engineers, 1993. http://dx.doi.org/10.3997/2214-4609.201411433.

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Reports on the topic "3D cellular structures"

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Rafaeli, Ada, Russell Jurenka, and Chris Sander. Molecular characterisation of PBAN-receptors: a basis for the development and screening of antagonists against Pheromone biosynthesis in moth pest species. United States Department of Agriculture, January 2008. http://dx.doi.org/10.32747/2008.7695862.bard.

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The original objectives of the approved proposal included: (a) The determination of species- and tissue-specificity of the PBAN-R; (b) the elucidation of the role of juvenile hormone in gene regulation of the PBAN-R; (c) the identificationof the ligand binding domains in the PBAN-R and (d) the development of efficient screening assays in order to screen potential antagonists that will block the PBAN-R. Background to the topic: Moths constitute one of the major groups of pest insects in agriculture and their reproductive behavior is dependent on chemical communication. Sex-pheromone blends are utilised by a variety of moth species to attract conspecific mates. In most of the moth species sex-pheromone biosynthesis is under circadian control by the neurohormone, PBAN (pheromone-biosynthesis-activating neuropeptide). In order to devise ideal strategies for mating disruption/prevention, we proposed to study the interactions between PBAN and its membrane-bound receptor in order to devise potential antagonists. Major conclusions: Within the framework of the planned objectives we have confirmed the similarities between the two Helicoverpa species: armigera and zea. Receptor sequences of the two Helicoverpa spp. are 98% identical with most changes taking place in the C-terminal. Our findings indicate that PBAN or PBAN-like receptors are also present in the neural tissues and may represent a neurotransmitter-like function for PBAN-like peptides. Surprisingly the gene encoding the PBAN-receptor was also present in the male homologous tissue, but it is absent at the protein level. The presence of the receptor (at the gene- and protein-levels), and the subsequent pheromonotropic activity are age-dependent and up-regulated by Juvenile Hormone in pharate females but down-regulated by Juvenile Hormone in adult females. Lower levels of pheromonotropic activity were observed when challenged with pyrokinin-like peptides than with HezPBAN as ligand. A model of the 3D structure of the receptor was created using the X-ray structure of rhodopsin as a template after sequence alignment of the HezPBAN-R with several other GPCRs and computer simulated docking with the model predicted putative binding sites. Using in silico mutagenesis the predicted docking model was validated with experimental data obtained from expressed chimera receptors in Sf9 cells created by exchanging between the three extracellular loops of the HezPBAN-R and the Drosophila Pyrokinin-R (CG9918). The chimera receptors also indicated that the 3ʳᵈ extracellular loop is important for recognition of PBAN or Diapause hormone ligands. Implications: The project has successfully completed all the objectives and we are now in a position to be able to design and screen potential antagonists for pheromone production. The successful docking simulation-experiments encourage the use of in silico experiments for initial (high-throughput) screening of potential antagonists. However, the differential responses between the expressed receptor (Sf9 cells) and the endogenous receptor (pheromone glands) emphasize the importance of assaying lead compounds using several alternative bioassays (at the cellular, tissue and organism levels). The surprising discovery of the presence of the gene encoding the PBAN-R in the male homologous tissue, but its absence at the protein level, launches opportunities for studying molecular regulation pathways and the evolution of these GPCRs. Overall this research will advance research towards the goal of finding antagonists for this important class of receptors that might encompass a variety of essential insect functions.
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