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Journal articles on the topic "363.705 193":
1
Baraliakos, X., E. Pournara, D. D. Gladman, P. J. Mease, S. Jahandideh, and L. Coates. "POS1110 PATIENT CLUSTERS IDENTIFIED BY MACHINE LEARNING: DATA FROM A POOLED ANALYSIS OF PHASE-3 TRIALS OF SECUKINUMAB IN PSORIATIC ARTHRITIS, ANKYLOSING SPONDYLITIS AND PSORIATIC ARTHRITIS WITH AXIAL MANIFESTATIONS." Annals of the Rheumatic Diseases 82, Suppl 1 (May 30, 2023): 879.1–879. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2975.
Abstract:
BackgroundUniversally acceptable criteria to define axial psoriatic arthritis (PsA) are lacking. Machine learning (ML) algorithms can detect patterns from large clinical datasets and identify clusters with potential therapeutic or prognostic significance in PsA patients (pts) with axial manifestations.[1]ObjectivesTo identify pt clusters based on baseline (BL) demographics and clinical indicators to support characterisation of the axial PsA phenotype within the spondyloarthritis (SpA) spectrum.MethodsPooled BL demographics and clinical data of secukinumab (SEC)-treated pts from 10 Phase-3 studies: FUTURE 1–5 (PsA), MEASURE 1–4 (ankylosing spondylitis, AS) and MAXIMISE (PsA with axial manifestations) were analysed to identify pt clusters by ML.[2]Finite mixture model methodology was applied to the pooled dataset. Longitudinal responses of SEC 300 mg vs 150 mg were explored across the identified clusters and clinical indicators tender joint counts (TJC), swollen joint counts (SJC) and enthesitis.ResultsEight distinct clusters were identified (n=3907,Figure 1 and Table 1). Pts with PsA with axial manifestations (MAXIMISE) were overrepresented in clusters 6–8. Pts in cluster 6 (mean age 48 yrs; 46% male) were overweight with pronounced psoriasis (PsO), and high articular burden in large joints. Pts in cluster 7 (mean age 47 yrs; 53% male) were less overweight with lower polyarticular joint counts (mean 11 joints) and tenderness focused on the feet, wrists and hands. Pts in cluster 8 were mostly pts with AS (mean age 43 yrs; 64% male), less overweight with oligoarthritis and high prevalence of spinal pain. Pts with PsA (FUTURE) were overrepresented in clusters 1–5. Longitudinal analysis showed significant improvements with SEC 300 mg vs 150 mg in clusters 6 and 8 for TJC, and cluster 7 for SJC.ConclusionPsA clusters obtained by ML in the pooled dataset indicate phenotypical heterogeneity of pts with PsA with axial manifestations and overlapping features across the SpA spectrum.References[1]Pournara E et al. RMD Open 2021;7:e00184[2]Baraliakos X et al. Arthritis Rheumatol 2022; 74 (suppl 9)Table 1.Pt characteristics by clusterH-SWO/TENACH (++)M-SWO/TENACH (+)L-SWO/TENPsO (+)M-SWO/TENPsO (+)L-SWO/TENACH (-)L-SWO/TENACH (+)PsO (++)L-SWO/ M-TENDAC (-)VL-TEN-SWOACH/DAC/PsO (-)Variables, mean (SD) unless specifiedCluster 1 (n=567)Cluster 2 (n=420)Cluster 3 (n=164)Cluster 4 (n=452)Cluster 5 (n=403)Cluster 6 (n=408)Cluster 7 (n=193)Cluster 8 (n=1300)Pt demographicsMale, n (%)225 (39.7)183 (43.6)98 (59.8)193 (42.7)239 (59.3)187 (45.8)103 (53.4)829 (63.8)BMI (kg/m2)30.0 (7.05)29.6 (6.53)28.5 (5.40)30.3 (6.68)28.1 (5.39)30.2 (6.15)28.6 (5.09)27.3 (5.41)Age (yrs)51.3 (11.58)47.8 (12.01)46.5 (11.59)49.9 (11.93)48.4 (12.20)48.2 (12.22)46.9 (11.67)42.9 (12.14)Clinical indicatorsSJC14.6 (8.44)7.2 (4.49)4.0 (1.93)8.8 (4.00)5.5 (2.80)5.0 (2.43)3.7 (2.78)0.9 (1.30)TJC29.0 (7.22)16.0 (4.87)7.2 (2.67)15.1 (4.48)7.5 (3.21)8.6 (2.76)10.9 (3.12)2.5 (2.40)ACH tendon*1 (0.91)0.9 (0.90)0.4 (0.66)0.5 (0.76)0.2 (0.57)0.7 (0.88)0.5 (0.75)0.3 (0.64)DAC, n (%)247 (43.6)156 (37.1)76 (46.3)171 (37.8)139 (34.5)150 (36.8)48 (24.9)206 (15.9)PsO, n (%)254 (44.9)185 (44.0)85 (51.8)233 (51.5)197 (48.9)252 (61.8)84 (43.5)410 (31.5)CRP >5 mg/L, n (%)278 (49.0)213 (50.7)71 (43.3)227 (50.2)155 (38.5)228 (55.9)86 (44.6)665 (51.2)Spinal pain, n (%)184 (32.5)176 (41.9)62 (37.8)138 (30.5)100 (24.8)162 (39.7)104 (53.9)1035 (79.6)StudiesTotal, n (%)FUTURE2453 (62.8)493 (87.0)323 (76.9)130 (79.3)386 (85.4)354 (87.8)303 (74.3)121 (62.7)343 (26.4)MAXIMISE485 (12.4)45 (7.9)43 (10.2)19 (11.6)45 (10.0)29 (7.2)65 (15.9)40 (20.7)199 (15.3)MEASURE969 (24.8)29 (5.1)54 (12.9)15 (9.2)21 (4.7)20 (5.0)40 (9.8)32 (16.6)758 (58.3)*ACH tendon enthesitis for right or left footACH, Achilles; DAC, Dactylitis; H, high; L, low; M, medium; n, number of evaluable pts; SWO, swollen; TEN, tender; VL, very lowAcknowledgements:NIL.Disclosure of InterestsXenofon Baraliakos Consultant of: Abbvie, Amgen, Chugai, Eli Lilly, Galapagos, Janssen, MSD, Novartis, Pfizer, Roche, Sandoz, UCB, Grant/research support from: Abbvie, Amgen, Chugai, Eli Lilly, Galapagos, Janssen, MSD, Novartis, Pfizer, Roche, Sandoz, UCB, Effie Pournara Shareholder of: Novartis, Employee of: Novartis, Dafna D Gladman Consultant of: Amgen, AbbVie, BMS, Celgene, Eli Lilly, Gilead, Galapagos, Janssen, Novartis, Pfizer and UCB, Grant/research support from: Amgen, AbbVie, Celgene, Eli Lilly, Janssen, Novartis, Pfizer and UCB, Philip J Mease Speakers bureau: AbbVie, Amgen, Lilly, Janssen, Novartis, Pfizer, and UCB, Consultant of: AbbVie, Aclaris, Amgen, Boehringer Ingelheim, BMS, Lilly, Galapagos, Gilead, GlaxoSmithKline, Inmagene, Janssen, Novartis, Pfizer, Sun Pharma, and UCB, Grant/research support from: AbbVie, Amgen, BMS, Lilly, Galapagos, Gilead, Janssen, Novartis, Pfizer, Sun Pharma and UCB, Samad Jahandideh Employee of: Novartis, Laura Coates Speakers bureau: AbbVie, Amgen, Biogen, Celgene, Eli Lilly, Galapagos, Gilead, GSK, Janssen, Medac, Novartis, Pfizer and UCB, Consultant of: AbbVie, Amgen, Bristol Myers Squibb, Celgene, Eli Lilly, Gilead, Galapagos, Janssen, Moonlake, Novartis, Pfizer and UCB, Grant/research support from: AbbVie, Amgen, Celgene, Eli Lilly, Janssen, Novartis, Pfizer and UCB.
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Barros, Aldre Jorge Morais, Beatriz Susana Ovruski de Ceballos, Annemarie König, and Hans Raj Gheyi. "AVALIAÇÃO SANITÁRIA E FÍSICO-QUÍMICA DAS ÁGUAS PARA IRRIGAÇÃO DE HORTALIÇAS NO AGRESTE E BREJO PARAIBANOS." Revista Brasileira de Engenharia Agrícola e Ambiental 3, no. 3 (December 1999): 355–60. http://dx.doi.org/10.1590/1807-1929/agriambi.v3n3p355-360.
Abstract:
RESUMO Foi avaliada a qualidade sanitária e físico-química das águas utilizadas na irrigação de hortaliças em cinco hortas localizadas em dois municípios paraibanos. As águas de irrigação apresentaram elevada contaminação fecal (CF: 104 UFC 100 mL-1) infectando os vegetais; esta contaminação teve como origem as descargas de esgotos domésticos nos córregos e açudes utilizados na irrigação, resultando no reúso indireto de esgotos na agricultura. As alfaces (Lactuca sativa L.) irrigadas com tais águas apresentaram concentrações de coliformes fecais entre 1,0 x 103 e 1,6 x 106 e de E. coli entre 2,5 x 102 e 2,5 x 104 NMP g-1, indicando riscos para a saúde dos consumidores, porém as alfaces provenientes dos mercados públicos apresentaram carga fecal entre 7,5 x 103 e 3,8 x 104 NMP g-1, não havendo diferenças significativas com aquelas das hortas. A elevada carga fecal do adubo orgânico de origem animal (valor médio entre 1,3 x 105 e 2,6 x 106 NMP g-1) comumente utilizada nas hortas também contribuiu na contaminação das alfaces. Do ponto de vista físico-químico, as águas de irrigação continham apreciáveis concentrações de sais, porém não apresentaram altos risco de salinização ou de sodificação do solo.
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Feng, Zhili, Kenneth J. Stadt, and Victor J. Lieffers. "Linking juvenile white spruce density, dispersion, stocking, and mortality to future yield." Canadian Journal of Forest Research 36, no. 12 (December 1, 2006): 3173–82. http://dx.doi.org/10.1139/x06-192.
Abstract:
We examined methods of linking density, dispersion, and stocking information from juvenile regeneration surveys with mortality estimates to predict future yield of white spruce (Picea glauca (Moench) Voss) in boreal mixedwoods. The study focused on data from 709 stands (7–150 years) and defined a stocked plot (10 m2) as having one or more acceptable trees. In juvenile surveys, ingress of natural spruce overwhelmed the regular planting pattern, creating clumped dispersion patterns, as indicated by the Morisita index. A function was developed to describe the relationship between stocking, density, and dispersion. In mature, permanent sample plots, only 30%–40% stocking of 10 m2 plots (700 stems·ha–1) was needed to achieve full yields. Mortality rates for planted spruce varied from 0.1% to 0.8% per year for juvenile stands and from 1.7% to 3.3% per year for mature stands. For rotation-length predictions in Alberta, 0.7% per year is likely a mean mortality loss. These findings were combined to generate stocking versus time curves at a range of mortality rates. The tallest spruce measured in each juvenile survey plot had the same mortality rate regardless of absolute size, and spruce mortality was reduced when associated with aspen. These findings call into question minimum height requirements and free-to-grow criteria in regeneration standards.
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Fernández de Sanmamed, José Luis Prada. "La construcción estatutaria del Estado autonómico español y sus problemas." Asamblea. Revista parlamentaria de la Asamblea de Madrid, no. 7 (December 1, 2002): 169–211. http://dx.doi.org/10.59991/rvam/2002/n.7/705.
Abstract:
Sumario: I. INTRODUCCIÓN HISTÓRICA A LA CUESTIÓN AUTONÓMICA.—1.1. La centralización durante el Estado absoluto español.—1.2. Centralismo y descentralización en nuestro Estado liberal.—1.3. Retazos históricos de la cuestión autonómica en el Estado republicano español.—II. LA EDIFICACIÓN CENTRISTA DEL ESTADO AUTONÓMICO ESPAÑOL.—2.1. La concesión de los regímenes preautonómicos.—2.2. La aprobación de la Constitución y de su Título VIII.—2.3. La aprobación de los primeros Estatutos de autonomía.—2.4. Los Acuerdos Autonómicos de 1981 y la LOAPA.—2.5. Aprobación de los Estatutos de autonomía por la vía del artículo 143 de la CE.—2.6. Otras medidas centristas en la conformación del Estado autonómico.—III. CONTINUACIÓN SOCIALISTA DE LA CONSTRUCCIÓN DE NUESTRO ESTADO AUTONÓMICO.—3.1. La aprobación de los restantes Estatutos de autonomía.—3.2. La reforma estatutaria de 1991.—3.3. Los Pactos autonómicos de 1992 y la reforma de 1994 de los Estatutos.—3.4. Otras contribuciones de la mayoría socialista a la edificación del Estado autonómico.—IV. APORTACIÓN DEL CENTRO-DERECHA A LA ULTIMACIÓN DE NUESTRO ESTADO DESCENTRALIZADO.—4.1. Los Estatutos de segunda generación, o reformados en la VI Legislatura.—4.2. Rectificaciones del Estado autonómico en la VII Legislatura.—4.3. Otras actuaciones autonómicas de la mayoría de centro-derecha en la VI y VII Legislaturas.—V. CONSIDERACIONES PROBLEMÁTICAS DE SÍNTESIS.—VI. ANEXO: RELACIÓN CRONOLÓGICA DE LOS ACTOS NORMATIVOS ESENCIALES EN LA CONSTRUCCIÓN DEL ESTADO AUTONÓMICO ESPAÑOL.
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Favreau, Amanda, Erin Cross, and Pradeep Sathyanarayana. "Mir-590-5p, Mir-219-5p, Mir-15b and Mir-628-5p Are Commonly Regulated by IL-3, GM-CSF and G-CSF in Acute Myeloid Leukemia,." Blood 118, no. 21 (November 18, 2011): 3520. http://dx.doi.org/10.1182/blood.v118.21.3520.3520.
Abstract:
Abstract Abstract 3520 IL-3, GM-CSF and G-CSF are predominant regulators for growth and differentiation of myeloid progenitors. Interestingly, they all signal via a common JAK2-STAT5 pathway in myeloid progenitor compartments. However, the specific mechanism through which JAK2-STAT5 responds differentially to early-acting and lineage restricted cytokines, particularly in leukemic and stem/progenitor cells, is largely unresolved. Aberrations in IL-3, GM-CSF and G-CSF induced signaling are frequently reported in acute myeloid leukemia (AML). microRNA (miRNA) play several crucial roles during hematopoiesis that include lineage decisions, stem cell progenitor transitions, niche control and other cell functions. Recent investigations have linked aberrant miRNA expression with AML. We hypothesized that a unique response of leukemic myeloid progenitors to IL-3, GM-CSF, and G-CSF are possibly mediated in part by distinct regulation at the miRNA level. Therefore, herein, by utilizing a unique leukemic myeloid cell line, AML-193, that responds to both early and late acting cytokines, we profiled IL-3, GM-CSF and G-CSF regulated miRNA signatures in leukemic myeloid progenitors. For miRNA profiling, AML-193 cells were initially exposed to IL-3 for 3 days followed by GM-CSF for 3 more days and subsequently to G-CSF for 3 days. We then profiled miRNA expression induced by IL-3, GM-CSF and G-CSF in AML-193 cells by treating the respective cohorts post growth factor deprivation with corresponding cytokines. Using SA Bioscience's complete Human V2.0 miRNA Genome Array platform for real-time qPCR-based miRNA expression profiling, we investigated miRNA signatures regulated by IL-3, GM-CSF and G-CSF for n=704 miRNAs in AML-193 cells. Frequencies of false positives were avoided using stringent filters. IL-3 specifically regulated 54 miRNAs and those miRNAs that were highly regulated included miR-362-3p, miR-590-3p, miR-340, miR-24-2, miR-1183 and miR-99a. GM-CSF specifically regulated miRNAs included let-7f, let-7a*, miR-195, miR-122, miR-376-c and miR-33a. G-CSF specifically regulated set included miR-21*, miR-192*, miR-32*, miR-7-1*, miR-545* and miR-37-4a*. Interestingly, 301 miRNAs were commonly regulated by IL-3, GM-CSF and G-CSF. Among the commonly regulated miRNAs, the ones that were subjected to high levels of regulation included miR-590-5p, miR-219-5p, miR-92-a1*, miR-378*, miR-548-3p, miR-29a*, miR-590-3p, miR-203, miR-363, miR-454, miR-340, miR-196a, miR-152, miR-10b, miR-24-2*, miR-10a, miR-182, miR-27a*, and miR-199a-3p. Interestingly, the commonly regulated miRNAs demonstrated a directional regulation in the order of IL-3>GM-CF>G-CSF. Analysis of the potential targets of significantly regulated miRNAs revealed important functional roles in myeloid cell development and differentiation. Conserved targets of miR-590-5p included BMPR2, PCBP2 and KLF3. Targets for miR-219-5p included Smad4 and GADD45b. Targets for miR-362-3p included Sox17, an inhibitor of the Wnt signaling pathway. Furthermore, to identify the JAK2-STAT5 responsiveness of miR-219-5p, miR-362-3p, and miR-590-5p, a STAT5 specific inhibitor (N′-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide) was used prior to cytokine treatment. Interestingly, IL-3 and GM-CSF mediated induction of miR-590-5p, miR-219-5p and miR-362-3p were not significantly affected by STAT5 inhibitor. However, the G-CSF induction of miR-219-5p and miR-590-5p were significantly inhibited by the STAT5 specific inhibitor. In summary, we have discovered for the first time novel miRNA profiles regulated by IL-3, GM-CSF and G-CSF in an acute myeloid leukemia progenitor cell model. Importantly, we have established a cytokine regulated miRNome for leukemic myeloid progenitors and set the stage for future investigations in leukemic stem cells to delineate the pathological roles of dysregulated miRNAs in AML. In addition, our study displayed that G-CSF induced a subset of miRNAs that are principally regulated via the STAT5 circuit in AML. Further, these novel miRNA signatures may have therapeutic implications for targeting dysregulated miRNAs by antagomir strategy or miRNA replacement therapy, paving the way for the development of novel miRNA-based therapeutic interventions in AML. Disclosures: No relevant conflicts of interest to declare.
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Izumi, Namiki, Masatoshi Kudo, Kenta Motomura, Yoshitaka Inaba, Yoshio Katamura, Yasuteru Kondo, Kazuhisa Yabushita, Katsuaki Motoyoshi, and Junji Furuse. "A multicenter observational study of lenvatinib for unresectable hepatocellular carcinoma in Japan." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): e16118-e16118. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e16118.
Abstract:
e16118 Background: Lenvatinib is an oral tyrosine kinase inhibitor that has been available for treatment of unresectable hepatocellular carcinoma (uHCC) in Japan since March 2018. We conducted a multicenter prospective observational study to evaluate the safety and efficacy of lenvatinib in clinical practice. Methods: This study conducted as a prospective study, and enrolled patients with uHCC initially receiving lenvatinib as systemic therapy who gave informed consent from July 2018 through January 2019. The observation period per patient was 12 months and e-CRF was used. Results: 713 patients were registered at 133 clinical sites. The safety analysis set and efficacy analysis set were 703 patients. Patient baseline characteristics included median age:73.0 years (25 to 94), male/ female: 564/139, bodyweight: < 60kg/≥60kg: 323/380, HBV/HCV/alcohol/NAFLD or NASH: 137/287/167/88, Child-Pugh classification A/B or higher: 624/75, BCLC stage A/B/C/D: 57/291/332/11, Vp 0/1/2/3/4: 520/31/52/60/22, with/without extrahepatic metastasis: 236/461. Previous treatment (local and systemic therapy) for hepatocellular carcinoma is with/without TACE: 513/190, median number of TACE treatment: 3.0 times (1 to 26), with/without HAIC: 74/629, with/without TKI pretreatment: 131/572. The initial dose was 8 mg (80.5%) and 12 mg (68.2%) in patients with < 60 kg and ≥60 kg, respectively. Median relative dose intensity was 64.2% and the treatment continuation rate at 3 and 12 months after administration of lenvatinib were 67.3% and 24.8%. Regarding safety, the incidence of treatment-related adverse events (TRAEs) was 84.9% (grade 3 or higher: 42.5%). Common TRAEs (incidence rate ≥10%) were decreased appetite (23.9%), malaise (21.8%), hypertension (21.3%), proteinuria (18.3%), palmar-plantar erythrodysesthesia syndrome (16.5%), hypothyroidism (15.8%), and diarrhea (13.9%). TRAEs of grade 3 or higher （incidence rate ≥2.5%） were proteinuria (6.7%), hypertension (6.4%), malaise (3.8%), decreased appetite (3.6%), platelet count decreased (3.3%), palmar-plantar erythrodysesthesia syndrome (2.7%), diarrhea (2.7%) and hepatic encephalopathy (2.6%). The incidence of TRAEs leading to discontinuation of lenvatinib was 32.9％, and main TRAEs leading to discontinuation of lenvatinib were (incidence rate ≥2%) decreased appetite (6.3%), malaise (4.7%), proteinuria (3.3%) and hepatic encephalopathy (2.4%). Regarding efficacy, the ORR and DCR was 39.5% (95% CI: 35.1, 43.9) and 78.9% (75.1, 82.5) in 494 patients who were evaluated for the best response by mRECIST. The median OS was 498.0 days (95% CI: 439.0, -) in 703 patients. Conclusions: The incidence of TRAEs leading to discontinuation of lenvatinib tended to be higher than in phase 3 REFLECT trials (19.7%), but the safety profile and effectiveness findings for lenvatinib in this study were consistent with previous reports.
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Burgos Peláez, Rosa, María Nuria Virgili Casas, María Cristina Cuerda Compés, José Manuel Moreno Villares, Gabriel Olveira, Luis Miguel Luengo Pérez, Carmina Wanden-Berghe Lozano, Álvaro Muñoz Cuadrado, Covadonga Torres González, and Miguel Ángel Casado Gómez. "Estimación del coste de la nutrición parenteral domiciliaria en España." Nutrición Hospitalaria 34, no. 2 (March 30, 2017): 271. http://dx.doi.org/10.20960/nh.705.
Abstract:
Introducción: la nutrición parenteral domiciliaria (NPD) mejora la calidad de vida de los pacientes permitiéndoles recibir nutrición en su domicilio y facilitando su integración social y laboral.Objetivo: analizar el coste de la NPD en España.Métodos: se realizó una revisión bibliográfica de los Registros de NPD en España (años 2007-2014), elaborados por el Grupo NADYA-SENPE. Se analizó la evolución de: pacientes que requerían NPD, episodios/paciente por los que se administró NPD, duración media de los episodios, vías de acceso y tasa de complicaciones. Se estimó el consumo y coste de la NPD. Los pacientes fueron agrupados según patología: benigna o maligna. Los costes directos (€, 2015) incluidos fueron: bolsas administradas, vías de acceso y complicaciones.Resultados: el número de pacientes que recibió NPD aumentó a lo largo de los años (2007: 133 pacientes; 2014: 220 pacientes). El número medio de episodios/paciente osciló entre 1-2 episodios/año y su duración media disminuyó (2007: 323 días; 2014: 202,8 días). Las vías de acceso más utilizadas fueron los catéteres tunelizados y las complicaciones sépticas fueron las más comunes. El coste directo anual medio por paciente se estimó en 8.393,30 € y 9.261,60 € para patología benigna y maligna, respectivamente. Considerando que, en 2014, 220 pacientes requirieron NPD, el coste anual fue 1.846.524,96 € (1.389.910,55 € debidos a la fórmula de NPD) y 2.037.551,90 € (1.580.937,50 € debidos a la fórmula de NPD) para patología benigna y maligna respectivamente.Conclusiones: estos resultados sirven de base para futuros análisis económicos de la NPD y para establecer estrategias de priorización eficiente de recursos disponibles.
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Tenório, Thiago R. S., P. Babu Balagopal, Lars B. Andersen, Raphael M. Ritti-Dias, James O. Hill, Mara C. Lofrano-Prado, and Wagner L. Prado. "Effect of Low- Versus High-Intensity Exercise Training on Biomarkers of Inflammation and Endothelial Dysfunction in Adolescents With Obesity: A 6-Month Randomized Exercise Intervention Study." Pediatric Exercise Science 30, no. 1 (February 1, 2018): 96–105. http://dx.doi.org/10.1123/pes.2017-0067.
Abstract:
Purpose: To investigate the effects of a low- versus high-intensity aerobic training on biomarkers of inflammation and endothelial dysfunction in adolescents with obesity. Methods: Sixty-two adolescents with obesity [age = 15 (14) y, body mass index = 34.87 (4.22) kg·m−2] were randomized to receive either a high-intensity training (HIT, n = 31) or a low-intensity training (LIT, n = 31) for 24 weeks. All participants also received nutritional, psychological, and clinical counseling. Leptin, total and subtype leukocyte counts, tumor necrosis factor-alpha, interleukin-6, myeloperoxidase, soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule-1 were obtained at baseline and after 24 weeks. Results: HIT reduced neutrophils [from 4.4 (1.9) to 3.6 (1.3) µL−1 × 103; P = .01] and monocytes [from 7.2 (2.5) to 5.2 (1.8) µL−1 × 102; P < .01], but LIT increased neutrophils [from 4.5 (1.7) to 5.2 (3.3) µL−1 × 103; P = .01]. Although tumor necrosis factor-alpha increased in LIT [from 13.3 (7.5) to 17.7 (10.8) pg·mL−1; P = .01], it decreased in HIT [from 12.4 (7.5) to 11.3 (6.2) pg·mL−1; P = .01]. No changes in leukocyte counts, soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, and homeostasis assessment model for insulin resistance were observed. Conclusions: Both HIT and LIT improved the inflammatory profile. The study, however, indicated that the number of biomarkers and the magnitude of changes were higher in the HIT compared with LIT.
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Aguiar, D. M., G. T. Cavalcante, M. F. V. Marvulo, J. C. R. Silva, A. Pinter, S. A. Vasconcellos, Z. M. Morais, M. B. Labruna, L. M. A. Camargo, and S. M. Gennari. "Fatores de risco associados à ocorrência de anticorpos anti-Leptospira spp. em cães do município de Monte Negro, Rondônia, Amazônia Ocidental Brasileira." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 59, no. 1 (February 2007): 70–76. http://dx.doi.org/10.1590/s0102-09352007000100012.
Abstract:
Foram testados, pela técnica de soroaglutinação microscópica aplicada à leptospirose, 329 cães provenientes do município de Monte Negro, RO, dos quais 156 eram da área urbana e 173 da área rural. Simultaneamente foi aplicado questionário para verificar a existência de possíveis fatores de risco pela regressão logística. Abordaram-se questões referentes a idade, sexo, dieta, tipo de criação, ambiente, contato com outras espécies e hábito de caça. Foram detectadas reações com títulos >100 em 27,3%, com 90 cães positivos ao agente, das quais 23,7% eram da área (37/156) urbana e 30,6% (53/173), da área rural (P>0,05). Os sorovares predominantes, reatores com títulos mais elevados, foram Autumnalis (22%), Pyrogenes (12%), Canicola (10%) e Shermani (7,5%). Cães com idade acima de 12 meses apresentaram maior ocorrência de anticorpos quando comparados aos cães mais jovens (P<0,05). Dentre os fatores de risco analisados, foram significativos a alimentação (dieta à base de ração comercial - odds ratio: 3,3; intervalo de confiança: 95%: 1,2 - 9,2; P=0,02) e o sexo (macho - odds ratio: 2,3; intervalo de confiança: 95%: 1,3 - 3,9; P=0,003). Ressalta-se a ocorrência de reações para sorovares mantidos na natureza por animais silvestres.
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Kutluk, M. Tezer, and Akif Yesilipek. "Turkish National Pediatric Cancer Registry 2002-2008 (Turkish Pediatric Oncology Group and Turkish Pediatric Hematology Society)." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): 10067. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.10067.
Abstract:
10067 Background: In childhood cancers cure rates increased up to 80% in the developed countries. On the other hand cure rates goes down 10-20% percent in countries with low resource settings. Reliable pediatric cancer data is essential for all countries. We established a nationwide pediatric cancer registry. Methods: Turkish Pediatric Oncology & Pediatric Hematology Society established a web-based database for the registry of all pediatric cancers. 11898 cases were registered between 2002-2008 from 65 centers. Various demographic data & survival endpoints were recorded & analyzed. Diseases were grouped according to the International Classification of Childhood Cancer. Results: In all 11898 cases, median age was 6 years (M/F= 6786/5112=1.32). Distribution in age groups were: 0-4 years, 42.5%; 5-9 years, 27.2%; 10-14 years, 23.4%; 15-19 years, 6.8%; >19 years, 0.1%. Only 3.8% of cases were diagnosed with clinical+radiological, the rest with histopathological data Distribution of cases in disease groups were [median age in yrs, M/F]: Leukemias (n=3777) 31.7% [5.5, 2137/1640=.31]; Lymphomas (n=2040) 17.1% [8.3, 1405/635=2.21]; CNS tumors (n=1588) 13.3% [6.9, 913/675=1.3 ]; Sympathetic tumors (n=889) 7.5% [2.1, 453/436=1.03]; Retinoblastoma (n=371) 3.1% [2, 181/190=0.95]; Renal tumors (n=655) 5.5% [3, 333/322=1.03]; Hepatic (n=166) 1.4% [1.8, 101/65=1.5]; Bone tumors (n=717) 6% [12.2, 407/310=1.3]; Soft tissue tumors (n=773) 6.5% [6.5, 442/331=1.3]; Germ cell tumors (n=531) 4.5% [5, 210/321=0.6 ]; Carcinomas and other malignant epithelial tumors (n=323) 2.7% [12, 164/159=1.03]; Others/unspecified malignant tumors (n=68) 0.6% [4.5, 40/28=1.4]. Five-year overall survival in all cases was 65%. Conclusions: This registry provides a critical information about the distribution of childhood cancer since this is the only nationwide pediatric cancer registry in Turkey. With the recent trends in non-communicable diseases at global level, registry data will be very helpful for national cancer control plans, which will also be used to compare at national and international level. This will also be a good example for many other countries with similar resources to do such projects.
Dissertations / Theses on the topic "363.705 193":
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Considine, Marie. "The social, political and economic determinants of a modern portrait artist, Bernard Fleetwood-Walker (1893-1965)." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3639/.
Abstract:
As the first major study of the portrait artist Bernard Fleetwood-Walker (1893-1965), this thesis locates the artist in his social, political and economic context, arguing that his portraiture can be seen as an exemplar of modernity. The portraits are shown to be responses to modern life, revealed not in formally avant-garde depictions, but in the subject-matter. Industrial growth, the increasing population, expanding suburbs, and a renewed interest in the outdoor life and popular entertainment are reflected in Fleetwood-Walker’s artistic output. The role played by exhibition culture in the creation of the portraits is analysed: developing retail theory affected gallery design and exhibition layout and in turn impacted on the size, subject matter and style of Fleetwood-Walker’s portraits. Emerging, and soon dominant, tabloid newspapers shaped content and language to attract readers, influencing the articulation of the reception of the artist’s work. This thesis also makes a contribution to the regional perspective, demonstrating the temporary co-existence of multiple, heterogeneous, modern art worlds. Throughout the thesis the relevance of economic factors is emphasised, reappraising the Marxist theory of modern art and concluding that a more complex economic description is required to provide a sensitive and insightful analysis of art history.
Books on the topic "363.705 193":
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Лабунька, М. Коли ліс був наш батько. Філядельфія ; Мюнхен ; Львів ; Київ: [б. в.], 2015.
Abstract:
У пр. №1714538 напис: Вельмишановному д-рові Володимирові Сергійчуку - Моєму дорогому Професорові з найкращими побажаннями з нагоди наступаючої ювілейної 75-ої річниці легенарної У.П.А.! СЛАВА УКРАЇНІ! З повагою та вдячністю, щиро Ваш, Ілля Лабунька 13-го жовтня 2017 р. б. Нью Йорк
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United States International Trade Commission. Industrial phosphoric acid from Belgium and Israel: Determinations of the Commission in investigation no. 701-TA-286 (final) under the Tariff Act of 1930, together with the information obtained in the investigation; determinations of the Commission in investigations nos. 731-TA-365 and 366 (final) under the Tariff Act of 1930, together with the information obtained in the investigations. Washington, DC: U.S. International Trade Commission, 1987.
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United States International Trade Commission. Industrial phosphoric acid from Belgium and Israel: Determinations of the Commission in investigation no. 701-TA-286 (final) under the Tariff Act of 1930, together with the information obtained in the investigation; determinations of the Commission in investigations nos. 731-TA-365 and 366 (final) under the Tariff Act of 1930, together with the information obtained in the investigations. Washington, DC: U.S. International Trade Commission, 1987.
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Commission, United States International Trade. Industrial phosphoric acid from Belgium and Israel: Determinations of the Commission in investigations nos. 701-TA-285 and 286 (preliminary) under the Tariff Act of 1930, together with the information obtained in the investigations, determinations of the Commission in investigations nos. 731-TA-365 and 366 (preliminary) under the Tariff Act of 1930, together with the information obtained in the investigations. Washington, DC: U.S. International Trade Commission, 1986.
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United States International Trade Commission. Industrial phosphoric acid from Belgium and Israel: Determinations of the Commission in investigations nos. 701-TA-285 and 286 (preliminary) under the Tariff Act of 1930, together with the information obtained in the investigations, determinations of the Commission in investigations nos. 731-TA-365 and 366 (preliminary) under the Tariff Act of 1930, together with the information obtained in the investigations. Washington, DC: U.S. International Trade Commission, 1986.
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Commission, United States International Trade. Certain acetylsalicylic acid (aspirin) from Turkey: Determination of the Commission in investigation no. 701-TA-283 (preliminary) under the Tariff Act of 1930, together with the information obtained in the investigation : determination of the Commission in investigation no. 731-TA-364 (preliminary) under the Tariff Act of 1930, together with the information obtained in the investigation. Washington, DC: U.S. International Trade Commission, 1986.
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Commission, United States International Trade. Porcelain-on-steel cooking ware from Spain: Determination of the Commission in investigation no. 701-TA-279 (preliminary) under the Tariff Act of 1930, together with the information obtained in the investigation : determination of the Commission in investigation no. 731-TA-336 (preliminary) under the Tariff Act of 1930, together with the information obtained in the investigation. Washington, DC: U.S. International Trade Commission, 1986.
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United States International Trade Commission. Certain acetylsalicylic acid (aspirin) from Turkey: Determination of the commission in investigation no. 701-TA-283 (final) under the Tariff Act of 1930, together with the information obtained in the investigation : determination of the commission in investigation no. 731-TA-364 (final) under the Tariff Act of 1930, together with the information obtained in the investigation. Washington, DC: U.S. International Trade Commission, 1987.
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United States International Trade Commission. Porcelain-on-steel cooking ware from Spain: Determination of the Commission in investigation no. 701-TA-279 (preliminary) under the Tariff Act of 1930, together with the information obtained in the investigation : determination of the Commission in investigation no. 731-TA-336 (preliminary) under the Tariff Act of 1930, together with the information obtained in the investigation. Washington, DC: U.S. International Trade Commission, 1986.
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United States International Trade Commission. Porcelain-on-steel cooking ware from Spain: Determination of the Commission in investigation no. 701-TA-279 (preliminary) under the Tariff Act of 1930, together with the information obtained in the investigation : determination of the Commission in investigation no. 731-TA-336 (preliminary) under the Tariff Act of 1930, together with the information obtained in the investigation. Washington, DC: U.S. International Trade Commission, 1986.
Book chapters on the topic "363.705 193":
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"Q 72-2 a) What was the primary blueprint for Art. 72 CISG? b) In what way has Art. 72 CISG extended this model? Q 72-3 a) How must the requirement that an anticipatory fundamental breach must be ‘clear’ be distinguished from the prerequisite in Art. 71 CISG that it must ‘become apparent’ that one party will not perform a sub-stantial part of its obligations? b) Wherein was the ‘clear’ committal of an anticipatory fundamental breach in C 72-1 to be seen? Q 72-4 Compare the ‘clarity’ requirement with the corresponding provisions in the UP 2004, the PECL, § 2-610(2) UCC, and § 323(4) BGB. Q 72-5 a) What is the purpose of the ‘notice’ requirement in Art. 72(2) CISG? b) In which cases will a notice within the meaning of Art. 72(2) CISG not be required? Cf. also C 72-2. Q 72-6 a) What are the consequences if no notice under Art. 72(2) CISG is given? b) What happens if the debtor cannot furnish any adequate assurance? Q 72-7 a) How is ‘repudiation’ defined in the UCC? b) Does the UCC make a similar distinction to that made under Arts 71, 72 CISG? c) What are the creditor’s possible remedies in case of repudiation by the other party? Q 72-8 a) How does the UCC settle the conflict between renewed willingness on behalf of the debtor to perform, and the creditor’s already having resorted to a remedy incompatible with the debtor’s performance of the contract? b) How is this question solved under the CISG? Q 72-9 In case of repudiation of the contract by one party, § 2-610(1)(b) UCC refers the other party to the general remedies in § 2-703(2). In fact, is there a difference, in comparison to the CISG, with respect to the remedies available to the conforming party?" In International Sales Law, 549–51. Routledge-Cavendish, 2007. http://dx.doi.org/10.4324/9780203945445-190.
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"Régions Francophones réels Francophones occasionnels Population Nombre % Nombre % AFRIQUE 30 001 000 4,7 40 617 000 6,3 645 000 000 Afrique du Nord-Est 219 000 0,31 700 000 2 83 400 000 Maghreb 14 455 000 24,7 17 030 000 29 58 400 000 Afrique subsaharienne 13 477 000 3,3 19 745 000 4,8 489 140 000 OCÉAN INDIEN 1 850 000 13,2 2 142 000 15,2 14 060 000 AMÉRIQUE 8 682 000 1,23 565 000 0,5 714 000 000 Amérique du Nord 7 286 000 2,93 2000 000 1,3 247 806 000 Amérique centrale, Caraïbes 1 216 000 0,7 365 000 0,2 176 794 000 Amérique du Sud 180 000 0,06 289 4000 000 ASIE 1 627 000 0,05 810 000 0,03 3 060 000 000 Proche et Moyen-Orient 1 491 000 0,8 800 000 0,4 186 000 000 Extrême-Orient 136 000 0,005 10 000 0,0004 2 874 000 000 EUROPE 63 952 000 8,19 200 000 0,1 789 000 000 Europe de l’Ouest 62 872 000 17,5 5 200 000 1,4 360 000 000 Europe de l’Est et URSS 1 080 000 0,34 000 000 0,9 429 000 000 OCÉANIE 350 000 1,3 33 000 0,1 26 000 000 MONDE 104 612 2 54 225 000 1 5 234 000 000." In Francotheque: A resource for French studies, 219. Routledge, 2014. http://dx.doi.org/10.4324/978020378416-36.
Conference papers on the topic "363.705 193":
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Gomes Filho, José Euderaldo Costa, Ariane Silva da Rocha, Gisele Aparecida Fernandes, Rossana Verónica Mendoza López, and Maria Paula Curado. "PRE- AND POSTMENOPAUSAL BREAST CANCER IN COMPARISON OF CLINICAL AND PATHOLOGICAL FEATURES, HISTOLOGY, BIOMARKERS, AND MOLECULAR CLASSIFICATION." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2043.
Abstract:
The aim of this study was to analyze the clinical and pathological evolution, morphology, hormonal biomarkers (estrogen, progesterone, HER2, and Ki-67), and molecular classification in pre- and postmenopausal patients (age ≤50 years and >50 years). This is a cross-sectional study of 705 female patients with breast cancer. A total of 55.9% (n=394) of patients were above 50 years, whereas 44.1% (n=311) were aged 50 years or below. The laterality of the tumor was similar in both age groups on the right side, 50.2% (n=156) for premenopausal and 53.3 (n=210) for postmenopausal (p=0.226), as was the anatomical sublocation in the external upper quadrant, 44.9% (n=140) for premenopausal and 48.7% (n=192) for postmenopausal (p=0.063). As for T clinical staging, 37% (n=115) were classified as T2 in premenopausal while 47% (n=185) as T1 in postmenopausal (p <0.001); N0, 46.3% (n=144) and 57.6% (n=227) (p=0.043); M0, 92.3% (n=287) and 95.7% (n=377) (p=0.072); and pathological grade T1, 41.8 (n=130) and 48.2% (n=190) (p=0.056); N0, 52.4% (n=163) and 60.4% (n=238) (p=0.121); M0 94.9% (n=374) and 93.9% (n=292) (p=0.332); invasive ductal carcinoma, 86.5% (n=269) and 81% (n=319) (p=0.134); histological grade 2, 42.1% (n=131) and 44.9 (n=177) (p<0.001); nuclear grade 3, 67.2% (n=209) and 54.1% (n=213) (p=0.002); HER2 negative, 75.7% (n=234) and 77.2% (n=295) (p=0.062); estrogen positive, 78.4% (n=243) and 78.4% (n=309) (p=0.731); progesterone positive, 70.6% (n=219) and 68.8% (n=271) (p=0.503); Ki-67 positive, 99.7% (n=303) and 100% (n=368) (p=0.005); and molecular classification defined as luminal B, 57.8% (n=178) and 49% (n=187) (p=0.009), respectively. We observed that in pre- and postmenopausal women with breast cancer, there was no difference in characteristics, anatomical location, and T staging. However, there was a significant difference in histological grade, nuclear grade, and the molecular subtype and staging.
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Hendricks, Robert C., Thomas A. Griffin, George A. Bobula, Robert C. Bill, and Harold W. Howe. "Integrity Testing of Brush Seal in Shroud Ring of T-700 Engine." In ASME 1993 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1993. http://dx.doi.org/10.1115/93-gt-373.
Abstract:
A split-ring brush seal was fabricated, installed between two labyrinth-honeycomb shroud seals, and tested in the fourth-stage turbine of a T-700 engine. The annealed Haynes 25 bristles rubbed directly against the nonconditioned, irregular René 80 turbine blade shroud surface. A total of 21 hr of cyclic and steady-state data were taken with surface speeds to 335 m/s (1100 ft/s) and shroud temperatures to 620 °C (1150 °F). Wear appeared to be rapid initially, with an orange flash of hot brush fragments during the first engine startup, to minimal after 10 hr of operation. The brush survived the testing but experienced some bristle pullouts and severe bristle wear; some turbine interface wear and possible material transfer was noted. Future design concerns center on tribological behavior at the interface with or without lubricants.
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Gomes Filho, José Euderaldo Costa, Ariane Silva da Rocha, Gisele Aparecida Fernandes, Rossana Verónica Mendoza López, and Maria Paula Curado. "SOCIODEMOGRAPHIC AND LIFESTYLE FACTORS IN PRE- AND POSTMENOPAUSAL PATIENTS WITH BREAST CANCER." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2103.
Abstract:
To analyze pre- and postmenopausal patients with breast cancer with regard to sociodemographic factors. This is a crosssectional study with 705 patients with breast cancer. Patients aged 50 years and older accounted for 55.9% (n=394), whereas those aged 50 years or younger accounted for 44.1% (n=311). For both pre- and postmenopausal patients, there is greater proportional access through the Unified Health System (SUS), 62.7% (n=195) and 51.5% (n=203) (p=0.002); married, 65.9% (n=205) and 52.8% (n=208) (p<0.001); white ethnicity, 75.9% (n=236) and 77 (n=302) (p=0.623); and undergraduate level, 48.1% (n=149) and 40.1% (n=158) (p<0.001). For 82.7% (n=272) of the SUS participants and 80.9% (n=276) of those with complementary health care (p<0.001), the first mammogram was performed between the ages of 18 and 40 years; own housing for 74.2% (n=230) and 85.6% (n=333) (p<0.001), denied tobacco use, 78.1% (n=243) and 64.8% (n=254) (p<0.001); and alcohol consumption, 76.2% (n=237) and 86.2% (n=337) (p<0.001); the reference of cancer cases in the family occurred in 55.9% (n=118) and 63.7% (n=174) (p=0.300); however, breast cancer cases were reported in only 44.1% (n=93) and 36.3% (n=99) (p=0.187); the body mass index (BMI) was considered eutrophic, 43.7% (n=136) and 37.9% (n=149) (p<0.001). The pre- and postmenopause results showed differences regarding access to treatment, marital status, education, housing, first mammogram, alcohol and tobacco consumption, and BMI. Therefore, sociodemographic and lifestyle factors show a difference in patients with breast cancer in pre- and postmenopause.
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Gomes Filho, José Euderaldo Costa, Ariane Silva da Rocha, Gisele Aparecida Fernandes, Rossana Verónica Mendoza López, and Maria Paula Curado. "CLINICAL AND PATHOLOGICAL CHARACTERISTICS AND MOLECULAR SUBTYPES IN A PROSPECTIVE COHORT OF PATIENTS WITH BREAST CANCER ACCORDING TO ACCESS TO TREATMENT: SUPPLEMENTARY HEALTH CARE VERSUS UNIFIED HEALTH SYSTEM." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2042.
Abstract:
The aim of this study was to describe the clinical and pathological characteristics and molecular subtypes in a prospective cohort of patients with breast cancer based on access to treatment — Supplementary Health Care versus Unified Health System (UHS). This is a cross-sectional study aligned to a prospective cohort developed at Hospital AC Camargo Cancer Center with 705 female patients, aged between 18 and 93 years and diagnosed with breast cancer. They had access to treatment by Supplementary Health (56.5%, n=398). Tumor topography for both UHS and Supplementary Health group include higher right breast, 53.4% (n=164) and 50.8 (n=202) (p=0.226); sublocation in the upper outer quadrant, 40.4% (n=124) and 52.3% (n=208) (p<0.001); T1 clinical staging, 37.8% (n=116) and 42.2% (n=168) (p<0.001); N0, 50.5% (n=155) and 54.3% (n=216) (p=0.109); and M0, 95.1% (n=292) and 93.5% (n=372) (p=0.667), respectively. For both UHS and Supplementary Health, pathological classification T1, 44.6 (n=137) and 46% (n=183) (p<0.001); the presence of regional lymph nodes and distant metastasis showing no difference in N0, 59.6% (n=183) and 54.8% (n=218) (p=0.451); M0, 93.8% (n=288) and 95% (n=378) (p=0.306); invasive ductal carcinoma, 81.4% (n=250) and 84.9% (n=338) (p<0.001); histological grade 2, 42.7% (n=131) and 44.5 (n=177) (p<0.001); nuclear grade 3, 60.3% (n=185) and 59.5% (n=237) (p=0.421); HER2 negative, 73.2% (n=216) and 79% (n=313) (p<0.001); estrogen positive, 80.4% (n=246) and 76.9% (n=306) (p=0.228); progesterone positive, 80.4% (n=246) and 76.9% (n=306) (p=0.280); Ki-67 positive, 99.6% (n=278) and 100% (n=393) (p<0.001); and molecular classification defined as Luminal B, 56.8% (n=167) and 50% (n=328), respectively. Access to treatment by UHS or Supplementary Health demonstrated significant difference in tumor sublocation, clinical and pathological T staging, morphology, histological grade, HER2, and Ki76, whereas there was no difference for clinical and pathological N and M staging, nuclear grade, estrogen, progesterone, and molecular classification.
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Li, X., J. L. Gaddis, and T. Wang. "Mist/Steam Cooling by a Row of Impinging Jets." In ASME Turbo Expo 2001: Power for Land, Sea, and Air. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/2001-gt-0151.
Abstract:
Closed loop steam has been chosen for cooling airfoils in heavy frame Advanced Turbine Systems (ATS) to improve efficiency. Enhanced cooling by the use of mist is considered to have potential to augment cooling by internal steam alone. Water droplets generally less than 10μm are added to 1.3 bar steam and injected through a row of four discrete round jets onto a heated surface. The Reynolds number is varied from 7500 to 22500 and the heat flux varied from 3.3 to 13.4 kW/m2. The mist increases the heat transfer coefficient along the stagnation line and downstream wanes in about 5 jet diameters. The heat transfer coefficient improves by 50 to 700 percent at the stagnation line for mist concentrations 0.75 to 3.5 percent by weight, depending on conditions. Off-axis maximum cooling occurs in most of the mist/steam flow but not in the steam-only flow. CFD simulation indicates that this off-axis cooling peak is caused by droplets’ interaction with the target walls.
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Silva, Grazielle Rosa da Costa e., Carla de Almeida Silva, Thaynara Lorrane Silva Martins, Winny Éveny Alves Moura, Lorrany Brito Montalvão, Karine Alves Cunha, Karlla Antonieta Amorim Caetano, Leonora Rezende Pacheco, Sheila Araújo Teles, and Megmar Aparecida dos Santos Carneiro. "Violência sexual entre imigrantes e refugiados de Goiás: prevalência e fatores associados." In XIII Congresso da Sociedade Brasileira de DST - IX Congresso Brasileiro de AIDS - IV Congresso Latino Americano de IST/HIV/AIDS. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/dst-2177-8264-202133p117.
Abstract:
Introdução: A migração é inerente à humanidade e, independentemente dos motivos de deslocamento, várias barreiras são enfrentadas pela população imigrante estrangeira e refugiada. A violação de direitos humanos, aqui representada pelos abusos sexuais, vêm aumento nesse grupo emergente e, consequentemente, o risco de infecções sexualmente transmissíveis. Objetivo: Estimar a prevalência do relato de violência sexual entre imigrantes e refugiados de Goiás e seus fatores associados. Métodos: Estudo transversal realizado de julho de 2019 a janeiro de 2020. Participaram 312 imigrantes e refugiados da região do Centro Goiano, Goiás. Foram incluídos indivíduos que relataram já ter iniciado atividade sexual. Todos foram entrevistados a partir de perguntas sobre dados sociodemográficos, imigração e comportamentos sexuais. A relação entre as variáveis preditoras e o relato de violência sexual foi analisada por meio da regressão logística. O estudo foi aprovado pelo Comitê de Ética da Universidade Federal de Goiás. Resultados: Participaram 312 indivíduos, sendo 56,4% homens e 43,6% mulheres. A maioria possuía idade entre 30 e 49 anos (51,3%), união estável (53,9%) e escolaridade de 6 a 12 anos (44,1%). Em relação às características de migração, 67,9% eram provenientes do Haiti (67,9%), enquanto 36,3% da Venezuela (26,3%); 23,4% viviam na condição de refugiados e 55,4% estavam no Brasil havia menos de um ano. A prevalência do relato de relação sexual forçada foi de 9,3%. As variáveis ser mulher (odds ratio=3,1, intervalo de confiança 95% 1,3–7,5) e ter feito sexo com parceria sabidamente portadora de infecções sexualmente transmissíveis (odds ratio=7,6, intervalo de confiança 95% 1,6–36) foram associados significativamente à violência sexual. Conclusão: Os dados afirmam uma condição presente de vulnerabilidade entre os imigrantes e refugiados investigados. É importante destacar o processo de feminização da imigração estrangeira e a necessidade de ações de educação em saúde visando ao empoderamento da mulher e à prevenção da saúde sexual.
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Lima, Reângela Cintia Rodrigues de Oliveira, Marli Teresinha Gimeniz Galvão, Juliana da Cunha Maia, and Maria Robervânia Rodrigues Lima. "Exposição do HIV em crianças no Ceará no período de 2020 a 2022." In XIV Congresso da Sociedade Brasileira de DST - X Congresso Brasileiro de AIDS - V Congresso Latino Americano IST/HIV/AIDS. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/dst-2177-8264-202335s1041.
Abstract:
Introdução: A epidemia de HIV passou a ter expressiva participação de mulheres no seu perfil epidemiológico e consequente aumento na exposição de crianças. Segundo o Ministério da Saúde do Brasil, considera-se criança exposta toda criança nascida de mãe HIV+ ou que tenha sido amamentada por mulher sabidamente com a infeção. Buscando reduzir a transmissão vertical, são preconizados medidas de controle que incluem o monitoramento de crianças expostas. Objetivo: Verificar a ocorrência de casos de crianças <12 anos expostas ao HIV no Ceará, no período de 2020 a 2022. Métodos: Estudo analítico e descritivo, realizado em julho de 2023, com dados secundários disponíveis nos boletins epidemiológicos de HIV de 2022 e pela plataforma IntegraSUS do Estado do Ceará, Brasil. O nível de confiança adotado foi 95%. Resultados: Entre 2020 e 2022, foram notificados 784 casos de crianças expostas ao HIV, tendo sua maior incidência nos anos de 2020 e 2021, com 276 (35%) e 362 (46%) casos, respectivamente. Maior ocorrência de casos (n=665) em crianças com <7 dias de vida (84,9%, média=222 ± DP=87,1, IC±19,3%). Entre 7 e 27 dias foram 59 casos (7,5%); com 1 ano, 4 (0,5%) casos; e entre 2 e 12 anos, 2 (0,2%) casos em cada ano. Foram ignorados 17 (2,2%) registros dessa informação no ano de 2021 e foram registrados 35 casos de AIDS em crianças <5 anos. Conclusão: Neste estudo foi evidenciado número expressivo de transmissão vertical de HIV em crianças. Urge no acompanhamento pré-natal com detecção precoce da infeção, tratamento adequado reduzindo possibilidade da transmissão vertical, pois crianças expostas ao HIV têm maior risco de intercorrências infecciosas, sendo significativo o impacto da AIDS para os serviços de saúde e, especialmente, para o binômio mãe-filho.
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Oliveira, Fábio Alves, Maria Alix Leite Araújo, Valéria Lima de Barros, Marilene Alves Oliveira Guanabara, Maria Vilani de Matos Sena, and Léa Dias Pimentel Gomes Vasconcelos. "Análise da puericultura de crianças notificadas com sífilis congênita na atenção primária à saúde." In XIII Congresso da Sociedade Brasileira de DST - IX Congresso Brasileiro de AIDS - IV Congresso Latino Americano de IST/HIV/AIDS. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/dst-2177-8264-202133p091.
Abstract:
Introdução: A sífilis congênita é resultado da transmissão do Treponema pallidum da gestante infectada com sífilis para o bebê, causando consequências graves para os recém nascidos. Objetivo: Analisar a puericultura de crianças notificadas com sífilis congênita na atenção primária em saúde. Métodos: Estudo descritivo realizado no município de Fortaleza, Ceará, que incluiu crianças notificadas com sífilis congênita nos anos de 2017 e 2018, em que havia registro de atendimento em unidades primárias de saúde. As variáveis analisadas foram: número de consultas, adequação do período da consulta para a idade, realização e resultado do teste não treponêmico de sangue periférico e no líquor, titulação, alteração liquórica, diagnóstico radiológico de ossos longos, realização de triagem auditiva e oftalmológica. Utilizou-se o programa Statistical Package for the Social Sciences, versão 20.0, e os resultados foram apresentados por meio de tabelas com medidas de tendência central. Resultados: Foram notificados, no Sistema de Informação de Agravos de Notificação, 1.611 casos de sífilis congênita e analisados 715 por corresponderem às crianças que apresentaram registro de pelo menos uma consulta de puericultura na unidade primária de saúde. Compareceram à unidade com um, dois, quatro, seis, nove e 12 meses, 68,7%, 36,3%, 19,6%, 9,9%, 3,0% e 0,1% crianças, respectivamente. Não houve registro de atendimento com 18 a 24 meses. Setecentos e treze (99,6%) receberam menos de oito consultas, 92,8% duas consultas, 73% três consultas, 55,5% quatro consultas, 27,9% cinco, 14,1% seis, 5,3% sete e 1,8% oito consultas. Encontraram-se informações de tratamento para sífilis em 7,2% prontuários, de realização de radiografia de ossos longos em 3,5%, de avaliação oftalmológica em 1,9%, de exame de Estudo Laboratorial de Doenças Venéreas em 1,3% e avaliação liquórica em 0,1%. O FTABs (sigla inglesa para fluorescent treponemal antibody absorption test) foi realizado aos 18 meses em 52%. Conclusão: A puericultura de crianças com sífilis congênita em Fortaleza não atende às diretrizes recomendadas pelo Ministério da Saúde.
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Ostrowski, JJ, K. Parikh, and A. Umar. "Piloting Tom Brown, a locally produced supplementary therapeutic food for the management of moderate acute malnutrition in Gombe State, Nigeria." In MSF Paediatric Days 2024. NYC: MSF-USA, 2024. http://dx.doi.org/10.57740/bvijtc.
Abstract:
BACKGROUND AND OBJECTIVES Over 50,000 children in Nigeria’s Gombe state have moderate acute malnutrition (MAM) and are at risk of deteriorating to severe acute malnutrition (SAM). An effective strategy to reduce mortality is through a targeted supplementary feeding programme delivered within community-based management of acute malnutrition (CMAM) interventions. We present findings from an outpatient therapeutic programme (OTP) which used Tom Brown for treating children with MAM. Tom Brown is a locally produced flour blend of sorghum, soybeans, and groundnuts, consumed as a sweetened porridge. METHODS We conducted retrospective analysis of patient data from OTP sites in three local government areas between October 2022 and December 2023. Data were extracted for children aged 6-59 months diagnosed with MAM, defined as absence of oedema; weight-for- height z-score (WHZ) ≥-3 and <-2; and/or mid upper arm circumference (MUAC) ≥11.5 and <12.5 cm. Those enrolled for at least 14 days and receiving 1.5 kg per week of Tom Brown were included. RESULTS Of the 1,207 cases of MAM treated, 1,089 (90.2%) recovered i.e. had two consecutive visits with WHZ >-2 and MUAC < 12.5 and no severe clinical complications; 91 (7.5%) defaulted; 21 (1.7%) did not improve; 4 (<1%) were transferred out; and 2 (<1%) died at the end of follow- up. During treatment, 197 (16.3%) deteriorated to SAM and were switched to ready-to-use therapeutic food. All deaths (n=2) deteriorated to SAM. For children who recovered without deterioration, average enrolment length was 36.3 (±15.8) days and average weight gain was 4.21 (±3.03) g/kg/day. CONCLUSIONS With acceptable recovery and low death rates, Tom Brown is a feasible alternative for treatment of MAM. Made with cheaper ingredients, it can potentially reach more children for the same cost, particularly when combined with frequent screening and early diagnosis in the community. Timely follow-up of defaulters may also improve adherence. Research is needed to understand Tom Brown’s effectiveness compared to commercial products or combination with cash-based assistance.
10
Ostrowski, JJ, K. Parikh, and A. Umar. "Piloting Tom Brown, a locally produced supplementary therapeutic food for the management of moderate acute malnutrition in Gombe State, Nigeria." In MSF Paediatric Days 2024. NYC: MSF-USA, 2024. http://dx.doi.org/10.57740/3mfoft.
Abstract:
BACKGROUND AND OBJECTIVES Over 50,000 children in Nigeria’s Gombe state have moderate acute malnutrition (MAM) and are at risk of deteriorating to severe acute malnutrition (SAM). An effective strategy to reduce mortality is through a targeted supplementary feeding programme delivered within community-based management of acute malnutrition (CMAM) interventions. We present findings from an outpatient therapeutic programme (OTP) which used Tom Brown for treating children with MAM. Tom Brown is a locally produced flour blend of sorghum, soybeans, and groundnuts, consumed as a sweetened porridge. METHODS We conducted retrospective analysis of patient data from OTP sites in three local government areas between October 2022 and December 2023. Data were extracted for children aged 6-59 months diagnosed with MAM, defined as absence of oedema; weight-for- height z-score (WHZ) ≥-3 and <-2; and/or mid upper arm circumference (MUAC) ≥11.5 and <12.5 cm. Those enrolled for at least 14 days and receiving 1.5 kg per week of Tom Brown were included. RESULTS Of the 1,207 cases of MAM treated, 1,089 (90.2%) recovered i.e. had two consecutive visits with WHZ >-2 and MUAC >12.5 and no severe clinical complications; 91 (7.5%) defaulted; 21 (1.7%) did not improve; 4 (<1%) were transferred out; and 2 (<1%) died at the end of follow- up. During treatment, 197 (16.3%) deteriorated to SAM and were switched to ready-to-use therapeutic food. All deaths (n=2) deteriorated to SAM. For children who recovered without deterioration, average enrolment length was 36.3 (±15.8) days and average weight gain was 4.21 (±3.03) g/kg/day. CONCLUSIONS With acceptable recovery and low death rates, Tom Brown is a feasible alternative for treatment of MAM. Made with cheaper ingredients, it can potentially reach more children for the same cost, particularly when combined with frequent screening and early diagnosis in the community. Timely follow-up of defaulters may also improve adherence. Research is needed to understand Tom Brown’s effectiveness compared to commercial products or combination with cash-based assistance.
Reports on the topic "363.705 193":
1
Leonard, Talayna, Robert Lemme, Cati Kral, Briana Santiago, Chris Elberts, Stephanie Dewald, Patrick McGonagill, et al. High-Percentage of Early Resectable Pancreatic Ductal Adenocarcinoma is Unidentified on Abdominal CT Obtained for Unrelated Diagnosis. Science Repository, December 2021. http://dx.doi.org/10.31487/j.aco.2021.02.03.
Abstract:
Objective: Pancreatic ductal adenocarcinoma (PDAC) has the best survival when detected early with 5-year survival near 40% for small, resectable PDAC. We evaluate the undiagnosed PDAC imaging features on routine CT and their impact on resectability. Methods: 76 of the screened 134 CTs from 1/1/2012 to 12/31/2018 using our tumor registry were obtained prior to PDAC diagnosis for other indications at least one month before presentation. Each cross-sectional study was reviewed for features of early PDAC: pancreatic mass, pancreatic ductal dilatation, perivascular/peripancreatic soft-tissue infiltration, omental lesions/ascites, and lymphadenopathy. When such features were detectible by the reviewing radiologists, the original CT readings were classified as concordant/discrepant. Descriptive statistics are reported for discrepant reads, tumor resectability, and tumor size. Results: Of the 76 cases from 46 unique subjects (30 male/16 female), 25 CTs (33%) had undetected PDAC imaging features: masses (15/19 unreported), ductal dilatation (16/20 unreported), and peripancreatic/perivascular soft-tissue infiltration (20/36 unreported). 63% of early PDAC features were not identified initially. One year before clinical diagnosis, 75-80% of the PDAC cases were resectable; at < 6 months before clinical diagnosis, only 29% were resectable. Conclusion: Improving early detection of key PDAC features on routine CT examinations can potentially improve patient outcomes.
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Sanabria Castellanos, Cindy Marleyi, Jorge Luis Díaz Moreno, and Hernán Quijada Bonilla. Investigación de brote por COVID-19 en un Centro de Protección de Personas Mayores, Leticia–Amazonas, mayo de 2020. Instituto Nacional de Salud, January 2021. http://dx.doi.org/10.33610/01229907.2021v3n1a2.
Abstract:
Antecedentes: en Leticia, Amazonas, en un Centro de Protección se presentó un brote por COVID-19. El primer resultado confirmado correspondió a una persona mayor con síntomas respiratorios. Objetivo: caracterizar las variables sociodemográficas y epidemiológicas de la población confirmada por COVID-19 en el centro de protección de personas mayores en Leticia, Amazonas en mayo de 2020. Materiales y métodos: se realizó un estudio de brote con diseño descriptivo transversal, en el cual se recolectó información de casos confirmados y probables por COVID-19 en personas de 60 años y más y funcionarios en un Centro de Protección en Leticia, Amazonas. Resultados: el centro de protección presentó 33 beneficiarios, con media de edad de 75,6 años. El 96,8 % (30) de los beneficiarios fue mayor de 60 años, el 70,5 % (12/17) del total de casos confirmados en población beneficiaria presentó síntomas; se identificó una razón de prevalencia 2,25 (IC 95 %: 1,02–4,97). La tasa de ataque en beneficiarios fue 51,6 % y en funcionarios de 48,4 %. Conclusión: las personas mayores alojadas en centros de protección presentan una alta tasa de contagios y muertes asociada a la presencia de comorbilidades y a la inapropiada implementación de protocolos de bioseguridad y cuidado.
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Santos Sales, Déborah, Mariana Beiral Hammerle, Rayanne da Silva Souza, Patricia Gomes Pinheiro, Débora Viana Freitas, Ana Carolina F. Herzog, Daniel Lucas de L. S. Santos, et al. Long Covid-19 Syndrome: the Prevalence of Neuropsychiatric Symptoms in Patients with Olfactory Disorders. Progress in Neurobiology, December 2023. http://dx.doi.org/10.60124/j.pneuro.2023.30.01.
Abstract:
Background: Among the frequently reported symptoms in long-term COVID-19 syndrome, we can highlight olfactory disorders depression, anxiety, and fatigue. OD can affect people's physical and mental health and can lead to neuropsychiatric symptoms. Objective: Determine the prevalence of symptoms of depression, anxiety, and fatigue in patients with olfactory disorders induced by long-term COVID-19; and investigate this impact on the quality of life. Methods: The study included 30 patients with confirmed long-term COVID-19, with persistent complaints of olfactory dysfunction. OD was evaluated by the connecticut smell test. Neuropsychiatric disorders were evaluated by the fatigue severity and hospital anxiety and depression scales. Quality of life was accessed using the SF-36. Results: 70% of the patients had different degrees of hyposmia and 20% had anosmia. The most prevalent symptom was depression with 66.7% of the sample. More than half of patients also had symptoms of anxiety and fatigue (53,3% both). The most affected dimensions of SF-36 were emotional, vitality, role physical and mental health (36.6 ± 44.0, 44.3 ± 28.7, 47.5 ± 42.7, 49.8 ± 24.7 respectively). There was a moderate negative correlation between symptoms of depression and the physical role and mental health dimension. There was a moderate negative correlation between anxiety and general health, vitality, social functioning, and mental health dimensions. Symptoms of fatigue obtained a moderate negative correlation in the physical function dimension. Conclusion: The prevalence of symptoms of depression, anxiety and fatigue is high in patients with olfactory disorders induced by long-term COVID-19, with a negative impact on the quality of life of these patients, highlighting the role emotional aspect.
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Hall, Linnea, Peter Larramendy, Lena Lee, and Annie Little. Landbird monitoring 2020 annual report: Channel Islands National Park. National Park Service, 2023. http://dx.doi.org/10.36967/2301088.
Abstract:
The National Park Service (NPS) began monitoring landbirds at Channel Islands National Park in 1993 as part of its long-term inventory and monitoring program. The park?s landbird monitoring later became part of the NPS Inventory and Monitoring Division?s Mediterranean Coast Network long-term monitoring programs. Consequently, landbird monitoring has been conducted in the park during every breeding season since 1993. In this report, we summarize data collected during the 2020 breeding season. Landbird monitoring was conducted between 1 April and 30 June 2020. Using distance-based sampling methods in a standardized protocol, birds were counted on 7 of 10 permanent line transects (70%) (2 of 3 on Santa Barbara Island, 1 of 1 on East Anacapa Island, and 4 of 5 on San Miguel Island). Two transects were not sampled in 2020 because of nesting California Brown Pelicans (Pelecanus occidentalis) on Santa Barbara Island (i.e., Canyons Transect) and reduced person hours and unfavorable winds on San Miguel Island (i.e., San Miguel Hill Transect). For point counts, 225 of 338 (67%) permanent stations were counted (i.e., 30 of 33 points on Santa Barbara Island, 8 of 8 on East Anacapa Island, 100 of 112 on Santa Cruz Island, 40 of 40 on San Miguel Island, and 47 of 145 on Santa Rosa Island). The 8 Prisoners? Cove points were not counted in 2020. Three points were not counted on Santa Barbara Island due to nesting pelicans: these points and the transect were also not counted in 2016?2019 to avoid disturbing breeding pelicans. Other points (i.e., on east Santa Cruz Island and Santa Rosa Island) were not counted due in large part to the global COVID-19 pandemic. Traveling to and from the park was only granted to essential NPS staff for the majority of the landbird season. Fifty-one bird species were counted from points and transects across all of the islands in 2020; 39 of these are breeding species on the island. Parkwide, the 10 most commonly detected breeding landbirds in 2020 were, in descending order: Horned Lark, Spotted Towhee, Song Sparrow, White-crowned Sparrow, Western Meadowlark, Orange-crowned Warbler, Bewick?s Wren, Island Scrub-Jay, House Finch, and Common Raven. On East Anacapa Island, 26 landbird species have been counted since 1993; 5 species were counted in 2020. No new transient species were detected in 2020; 10 transient or visiting species (nonbreeding, native species recorded only once or twice during surveys) have been counted on the island overall since 1993. On Santa Barbara Island, 49 landbird species have been counted since 1993; 15 species were counted in 2020. The highest number of Horned Lark since 1993 were counted in 2020 (n = 451). Warbling Vireo was a new transient species counted in 2020 on Santa Barbara; 30 transient or visiting species have been counted on the island since 1993. On Santa Cruz Island, 74 landbird species have been counted since 2013; 34 species were counted in 2020. Bullock?s Oriole was a new transient species counted in 2020 on Santa Cruz; 21 transient or visiting species have been counted on this island since 2013. On San Miguel Island, 69 landbird species have been counted since 1993; 14 were counted in 2020. No transient species were counted in 2020; 34 transient or visiting species have been counted on the island since 1993. On Santa Rosa Island, 75 landbird species have been counted since 1994; 26 were detected in 2020. Rose-breasted Grosbeak was a new transient species counted in 2020 on Santa Rosa Island; 30 transient or visiting species have been counted on the island since 1994. Across all the 5 islands, 3 transient or visiting bird species were newly counted in 2020, for a total of 77 such species counted since NPS monitoring began on the islands. Nonnative and invasive birds were counted on only 1 of the 5 islands in 2020: 4 European Starlings on Santa Rosa Island. However, anecdotal sightings of nonnative species occurred much more frequently (i.e., outside of the point and transect counts), and were made on all islands except Anacapa in 2020. The highest numbers of nonnative species detections occurred on Santa Cruz Island, with 33 detections of Eurasian Collared Dove (primarily at the Main Ranch area in the Central Valley), 15 detections of Brown-headed Cowbird (primarily at Scorpion Harbor), and 15 detections of European Starling (primarily at the Main Ranch and Scorpion Harbor). House Sparrows were observed fewer times, but on all islands except Anacapa; cowbirds occurred on all islands except Anacapa and San Miguel; and Rock Pigeon occurred on Santa Barbara and Santa Cruz Islands. In 2020, despite the COVID-19 pandemic, 67% of all points and 77% of all transects were counted among the 5 islands. Santa Rosa received the lightest sampling of points (32%), due to the difficulty of getting observers onto the island. Even with diminished sampling, species richness (number of species) values fell in predictable patterns: richness was greatest on the larger islands (75 on Santa Rosa, 73 on Santa Cruz) and least on the smallest islands (26 on Anacapa, 48 on Santa Barbara). We continue to recommend that nonnative invasive species, such as European Starlings on Santa Rosa Island, be removed before their numbers become harder to manage. Also, because Distance analyses assist statistically with evaluations of trends, we continue to recommend that a trend analysis using program DISTANCE, or newer hierarchical distance analyses, should be used after the 2020 season to assess 5-year trends in breeding species? numbers following the 2015 trend analysis conducted by Coonan and Dye (2016).
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Larramendy, Peter, Linnea Hall, and Annie Little. Landbird trends 2016–2021, and 2021 annual report: Channel Islands National Park. National Park Service, August 2023. http://dx.doi.org/10.36967/2299629.
Abstract:
The National Park Service (NPS) began monitoring landbirds at Channel Islands National Park in 1993 as part of its long-term inventory and monitoring program. The park’s landbird monitoring later became part of the NPS Inventory and Monitoring Division’s Mediterranean Coast Network long-term monitoring programs. Consequently, landbird monitoring has been conducted during every breeding season since 1993. In this report, we summarize data collected during the 2021 breeding season and we analyze trends in a select number of species. Landbird monitoring was conducted between 10 March and 22 May 2021. Using distance-based sampling methods in a standardized protocol, birds were counted on 334 of 338 permanent point count stations (99%) across the Channel Islands monitored for landbirds. These surveys were conducted at 29 of 33 points on Santa Barbara Island, 8 of 8 on East Anacapa Islet, 112 of 112 on Santa Cruz Island, 40 of 40 on San Miguel Island, and 145 of 145 on Santa Rosa Island. Four points on Santa Barbara Island were not counted due to nesting California Brown Pelicans (Pelecanus occidentalis) and Western Gulls (Larus occidentalis); 3 of 4 points (i.e., 17, 19, and 20) were also not counted in 2016–2021 to avoid disturbing breeding pelicans. This was the first monitoring season that the permanent line transects on Santa Barbara, East Anacapa, and San Miguel Islands were not surveyed. During the 2021 monitoring season, Channel Islands National Park decided to stop using line transects and focus on point count stations only, based on an external review of the landbird monitoring program. Fifty-six bird species were counted at point count stations across all of the islands in 2021. Parkwide, 40 of these species are breeders in Channel Islands National Park. Parkwide, the 10 most detected breeding landbirds in 2021 were, in descending order: Spotted Towhee, Song Sparrow, Bewick’s Wren, Orange-crowned Warbler, House Finch, Western Meadowlark, Horned Lark, Common Raven, Island Scrub-Jay, and Pacific-slope Flycatcher (scientific names in Table 2 and Appendix A). On East Anacapa Islet, 26 landbird species have been counted since 1993; 7 species were counted in 2021. No new transient species were detected in 2021; 6 transient or visiting species have been counted on the island overall since 1993. On Santa Barbara Island, 50 landbird species have been counted since 1993; 13 species were counted in 2021. Lincoln’s Sparrow was a new transient species counted in 2021 on Santa Barbara; 23 transient or visiting species have been counted on the island since 1993. On Santa Cruz Island, 78 landbird species have been counted since 2013; 45 species were counted in 2021. Hermit Warbler, Lawrence’s Goldfinch and Warbling Vireo were new transient species counted in 2021 on Santa Cruz Island; 21 transient or visiting species have been counted on this island since 2013. On San Miguel Island, 70 landbird species have been counted since 1993; 10 were counted in 2021. No transient species were counted in 2021; 32 transient or visiting species have been counted on the island since 1993. On Santa Rosa Island, 78 landbird species have been counted since 1994; 39 were detected in 2021. No new transient species were counted in 2021 on Santa Rosa; 21 transient or visiting species have been counted on the island since 1994. Nonnative and invasive birds were counted on only 1 of the 5 islands in 2021: 23 European Starlings on Santa Rosa Island. However, anecdotal sightings of nonnative species occurred more frequently (i.e., outside of survey times) on Santa Cruz and Santa Rosa Islands in 2021. The highest numbers of nonnative species detections occurred on Santa Rosa Island, with 25 detections of Eurasian Collared Dove (primarily at the Historic Ranch), 18 detections of European Starling (Historic Ranch), 2 detections of Brown-headed Cowbird, and 1 Rock Pigeon detection (Historic Ranch). Other species were not reported by Channel Islands National Park landbird monitors or in eBird in 2021. This was the first annual monitoring report since the Coonan and Dye (2016) trend report to incorporate density estimates for particular species across Channel Islands National Park. Parkwide, 13 species were analyzed using the Distance Package in R. Of the 13 species analyzed, 5 had either increasing or decreasing densities from 2016 to 2021. All park islands except for Santa Barbara had a species that showed an increasing or decreasing trend from 2016 to 2021. Horned Lark and House Finch on San Miguel Island were the only species to show decreasing trends from 2016 to 2021, which is opposite from the trend presented by Coonan and Dye (2016).
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Chou, Roger, Azrah Y. Ahmed, Benjamin J. Morasco, Christina Bougatsos, Tracy Dana, Rongwei Fu, and Terran Gilbreath. Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: 2023 Update. Agency for Healthcare Research and Quality, August 2023. http://dx.doi.org/10.23970/ahrqepccer250update2023.
Abstract:
Objectives. To update the evidence on benefits and harms of cannabinoids and other plant-based compounds to treat sub-acute and chronic pain in adults and adolescents using a living systematic review approach. Data sources. Ovid® MEDLINE®, PsycINFO®, Embase®, the Cochrane Library, and SCOPUS® databases; and reference lists of included studies were searched to April 23, 2023. Review methods. An updated protocol with expanded inclusion criteria (addition of sub-acute [4 to 12 weeks’ duration] pain and adolescents) was posted on the PROSPERO registry. We grouped studies based on their THC to CBD ratio and by product type, i.e. whole-plant (extracted or purified), or synthetic. We conducted random effects meta-analyses and categorized magnitude of benefit (large, moderate, small, or no effect [less than small]). Results. Two new RCTs (n=115 and 15) and two new observational studies (N=2,071) were added for this annual update; no study addressed subacute pain or adolescents. One new RCT compared high and low THC to CBD ratio products versus placebo; the other new RCT evaluated was very small and had methodological limitations. Since the inception of this living review, from 5,228 total abstracts identified, 23 RCTs (N=2,035) and 10 observational studies (N=15,840) assessing different cannabinoids were included; no study evaluated kratom. Studies were primarily short term, and 58 percent enrolled patients with neuropathic pain. Comparators were primarily placebo or usual care. Strength of evidence was low, unless indicated otherwise. Compared with placebo, plant-extracted, comparable ratio THC to CBD oral spray was associated with a small decrease in pain severity (7 RCTs, N=632, 0 to 10 scale, mean difference [MD] −0.54, 95% confidence interval [CI] −0.95 to −0.19, I2=39%; SOE: moderate) and overall function (6 RCTs, N=616, 0 to 10 scale, MD −0.42, 95% CI −0.73 to −0.16, I2=32%; SOE: moderate) versus placebo. There was no effect on study withdrawals due to adverse events. There was a large increased risk of dizziness and sedation, and a moderate increased risk of nausea (dizziness: 6 RCTs, N=866, 31.0% vs. 8.0%, relative risk [RR] 3.57, 95% CI 2.42 to 5.60, I2=0%; sedation: 6 RCTs, N=866, 8.0% vs. 1.2%, RR 5.04, 95% CI 2.10 to 11.89, I2=0%; and nausea: 6 RCTs, N=866, 13% vs. 7.5%, RR 1.79, 95% CI 1.19 to 2.77, I2=0%). Synthetic high-THC to CBD ratio products were associated with a small improvement in pain severity, a moderate increase in sedation, and a large increase in risk of nausea following the addition of one new RCT (pain: 7 RCTs, N=448, 0 to 10 scale, MD −0.95, 95% CI −1.81 to −0.25, I2=60%; sedation: 4 RCTs, N=386, 19% vs. 12%, RR 1.60, 95% CI 1.01 to 2.95, I2=8%; nausea: 3 RCTs, N=353, 11.1% vs. 5.2%, RR 2.22, 95% CI 0.90 to 5.05; I²=0%). There was also moderate SOE for a large increased risk of dizziness (3 RCTs, N=353, 29% vs. 11%, RR 2.52, 95% CI 1.20 to 4.82, I2=41%). Extracted whole-plant high-THC to CBD ratio products (oral) were associated with a large increased risk of study withdrawal due to adverse events (1 RCT, viii 13.9% vs. 5.7%, RR 3.12, 95% CI 1.54 to 6.33) and dizziness (1 RCT, 62.2% vs. 7.5%, RR 8.34, 95% CI 4.53 to 15.34); outcomes assessing benefit were not reported or insufficient. Evidence (including observational studies) on whole-plant cannabis, topical or oral CBD, low-THC to CBD products (2 new RCTs), other cannabinoids, comparisons with active non-cannabis treatments or between cannabis-related products, and impact on use of opioids also remained insufficient. Evidence was not available on important harms such as psychosis, cannabis use disorder, and cognitive effects. Conclusions. Low to moderate strength evidence suggests small improvements in pain (mostly neuropathic), and moderate to large increases in common adverse events (dizziness, sedation, nausea) with high and comparable THC to CBD ratio extracted cannabinoids and synthetic products versus placebo during short-term treatment (1 to 6 months) in adults with chronic pain. Evidence for low-THC to CBD ratio products, whole-plant cannabis, and other comparisons, outcomes, and plant-based compounds was unavailable or insufficient to draw conclusions.
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DiGrande, Laura, Christine Bevc, Jessica Williams, Lisa Carley-Baxter, Craig Lewis-Owen, and Suzanne Triplett. Pilot Study on the Experiences of Hurricane Shelter Evacuees. RTI Press, September 2019. http://dx.doi.org/10.3768/rtipress.2019.rr.0035.1909.
Abstract:
Community members who evacuate to shelters may represent the most socially and economically vulnerable group within a hurricane’s affected geographic area. Disaster research has established associations between socioeconomic conditions and adverse effects, but data are overwhelmingly collected retrospectively on large populations and lack further explication. As Hurricane Florence approached North Carolina in September 2018, RTI International developed a pilot survey for American Red Cross evacuation shelter clients. Two instruments, an interviewer-led paper questionnaire and a short message service (SMS text) questionnaire, were tested. A total of 200 evacuees completed the paper survey, but only 34 participated in the SMS text portion of the study. Data confirmed that the sample represented very marginalized coastline residents: 60 percent were unemployed, 70 percent had no family or friends to stay with during evacuation, 65 percent could not afford to evacuate to another location, 36 percent needed medicine/medical care, and 11 percent were homeless. Although 19 percent of participants had a history of evacuating for prior hurricanes/disasters and 14 percent had previously utilized shelters, we observed few associations between previous experiences and current evacuation resources, behaviors, or opinions about safety. This study demonstrates that, for vulnerable populations exposed to storms of increasing intensity and frequency, traditional survey research methods are best employed to learn about their experiences and needs.
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Ward, Kimiora. Sierra Nevada Network white pine monitoring: 2022 annual report. National Park Service, 2023. http://dx.doi.org/10.36967/2301003.
Abstract:
Five-needle white pines (Family Pinaceae, Genus Pinus, Subgenus Strobus), and in particular whitebark pine (Pinus albicaulis), limber pine (P. flexilis), and foxtail pine (P. balfouriana) are foundation species in upper subalpine and treeline forests of several National Park Service Pacific West Region parks, including Sequoia and Kings Canyon National Parks (SEKI) and Yosemite National Park (YOSE). The Sierra Nevada Network Inventory & Monitoring Program, in collaboration with the Klamath Network, Upper Columbia Basin Network, and Mojave Desert Network have implemented a joint long-term monitoring protocol to assess the current status and future trends in high elevation white pine communities. Key demographic parameters within white pine forest communities will be estimated by monitoring individual trees within permanent plots through time. This report documents the results of the 2022 field season, which was the ninth year of monitoring in SEKI and YOSE. The 2021 goal was to complete the first full measure of the third of three rotating panels (Panel 3) for each species-park population: YOSE-whitebark pine, SEKI-whitebark pine, and SEKI-foxtail pine. Each panel consists of 12 permanent 50 x 50 m (2,500 m2) plots that were randomly selected for each of the three populations. The full sampling array thus includes a total of 36 whitebark pine plots in YOSE, 36 whitebark pine plots in SEKI, and 36 foxtail pine plots in SEKI. Data from plot surveys will be used to characterize white pine forest community dynamics in SEKI and YOSE, including changes in tree species composition, forest structure, forest health, and demographics. Partial measures of Panel 3 were completed in 2017 (11 plots) in Yosemite whitebark pine, in 2017 (9 plots) in SEKI whitebark pine, and in 2014 (7 plots) and 2017-2018 (8, 1 plots) in foxtail pine. In 2022, the first full measure of all Panel 3 plots (and 2nd or 3rd remeasure of most plots) was successfully completed, and installation was completed on four of these plots in SEKI whitebark pine and two in foxtail pine. In total, the crew visited 36 sites during the 2022 field season, all from Panel 3. Within the 36 completed Panel 1 plots, a total of 6,398 trees were measured. Species composition, forest structure, and factors affecting tree health and reproduction including incidence and severity of white pine blister rust (Cronartium ribicola) infection, mountain pine beetle (Dendroctonus ponderosae) infestation, dwarf mistletoe (Arceuthobium spp.) infection, canopy kill, and female cone production were recorded. During the 2022 field season crews continued to count the total number of mature cones per tree for whitebark and foxtail pine, use crown condition codes to assess crown health, and tag individual seedlings to be tracked through time. All three of these procedures started in 2017 and are to be evaluated by each of the three participating networks over several years, to determine whether they should become permanent changes to the monitoring protocol. In YOSE, all 12 Panel 3 whitebark pine plots were measured. A total of 2,720 trees were sampled, which included 977 live whitebark pine trees and 1,605 other live conifers. An additional 135 trees (including 26 whitebark) were recorded as dead. The average number of live whitebark pine trees per plot was 81 (SD = 94). White pine blister rust (WPBR) aecia were observed on five whitebark pine in one plot in YOSE in 2022, and no trees in any plot had inactive cankers showing three or more indicators of WPBR. WPBR had previously been documented in this plot, so the number of plots where rust has ever been observed in Yosemite remains unchanged at six. However, an infection documented in plot 42 in 2021 was not observed again when the plot was resampled in 2022, so it is possible this number should be five. Mountain pine beetle activity was observed on one live whitebark pine and three live and one dead lodgepole pine in YOSE in 2022. Despite documentation of many stands impacted by beetle attack in the field crew notes, the quantified rate of MPB attack was lower than in 2021. Twenty-one percent of live whitebark pine trees produced female cones. Cone-bearing trees averaged 7 (SD = 10) cones/tree. Whitebark pine seedling density averaged 80 (SD = 152) seedlings per hectare. The largest number of whitebark pine seedlings found in a plot was 51 and five of the twelve plots contained whitebark seedlings. All 12 Panel 3 SEKI whitebark pine plots were measured in 2022, and installation was completed on four of these, so this Panel is now fully installed. Within these plots, 2,179 live whitebark pine, 10 live foxtail pine, and 297 other live conifers were sampled (including 5 live western white pine). The average number of live whitebark pine trees per plot was 181 (SD = 125). Although the crew observed white pine blister rust in seven SEKI whitebark Panel 3 plots, no active cankers (aecia) were observed, and no trees displayed 3 of 5 indicators, so no infections were quantified. Mountain pine beetle activity was observed in 18 live and 23 dead whitebark pine and 1 live and one dead lodgepole pine within three plots in SEKI. Dwarf mistletoe was not encountered. Seven percent of live whitebark pine trees produced female cones. Cone-bearing trees averaged 3.7 (SD = 3.6) cones/tree. Whitebark seedling regeneration averaged 700 (SD = 752) seedlings per hectare. The largest number of whitebark seedlings found in a plot was 19, and two of the 12 plots did not contain any whitebark seedlings. In the foxtail pine Panel 3, all 12 plots were measured in 2022, and installation was completed on two of these, so installation of the panel is now complete. Within these plots we measured 309 live foxtail pine, 302 live whitebark pine, and 380 other live conifers, including four live western white pine. An additional 112 dead or recently dead trees and 22 unidentified snags were also measured, 19 of which were foxtail pine. The average number of foxtail pine trees per plot was 26 (SD = 26). No signs of blister rust infection or mistletoe were observed on foxtail pine. Mountain pine beetle activity was observed on one dead foxtail pine, one live whitebark pine, and seven live and one dead lodgepole pines within four plots. Sixty-two percent of the foxtail pine trees produced female cones. Cone-bearing trees averaged 33 (SD = 53) cones/tree. Seven foxtail pine seedlings were recorded within five plots, resulting in an estimated 72 (SD = 98) seedlings per hectare. Eight whitebark pine seedlings and three lodgepole pine seedlings were also found within three additional plots.
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Franzén, Fredrik, Anna Lingman, and Emma Svahn. Biologisk recipientkontroll vid Oskarshamns kärnkraftverk : årsrapport för 2023. Department of Aquatic Resources, Swedish University of Agricultural Sciences, 2024. http://dx.doi.org/10.54612/a.j5a16unsqn.
Abstract:
Oskarshamns kärnkraftverk (OKG AB) påverkar den omgivande havsmiljön, främst genom användning av kylvatten. Den kylvattenpåverkade recipienten Hamnefjärdens vattentemperatur var i medeltal 3,3 °C varmare än det opåverkade närreferensområdet Borholmsfjärden under 2023. Revisionsavställningen under vår- och försommarperioden var något längre än vanligt. Under 2023 pågick inga särskilda studier av fiskförluster i kylvattenhanteringen och det rapporterades inga avvikande händelser från kraftverkets silstation. Revisionsavställningen från mitten av april till början av juni innebar en utebliven värmeökning i Hamnefjärden, vilket sannolikt påverkade resultatet i vårfisket med biologiska länkar till att en större andel av arterna var så kallade kallvattenarter som har högre förekomst i vatten med lägre temperaturer. Även ryssjefisket bör ha påverkats av detta och det kan vara en del i förklaringen till de låga ålfångsterna. I ryssjorna var förekomsten av både svartmunnad smörbult och storspigg hög i år igen. I sommar- och höstfiskena var fångsterna stora av abborre, mört, björkna och andra karpfiskar. I de med nätlänkar och nordiska kustöversiktsnät var även fångsterna av strömming stora. De skillnader vi såg i fiskfångsterna mellan områdena kan förklaras av naturliga skillnader i temperatur, exponeringsgrad och geografisk lokalisering snarare än påverkan av varmvattenutsläppen från kärnkraftverket. I vårens fiske med kustöversiktsnät utanför Hamnefjärdens mynning registrerades något fler strömmingar än de föregående tre åren, men fångsterna av de flesta för fisket vanligen förekommande arterna var låga. Störning från säl noterades i 75 procent av fiskeansträngningarna. Kalla vårar och försomrar under både 2022 och 2023 har gett avsaknad av både årsyngel och ett år gamla abborrar i provfisken både i Simpevarp och referensområdena. De varma somrarna 2018 och 2021 har däremot resulterat i att en ovanligt stor andel av de fångade abborrarna i provfiskena var två respektive fem år gamla. Antalet årsyngel av abborre och mört i höstens undersökningar med undervattensdetonationer var obefintligt respektive lågt i Hamnefjärden 2023. Konditionsvärdet för abborr- och mörthonor låg i samtliga områden omkring Simpevarp och Kvädöfjärden på eller över gränsvärdet för god kondition. Vid 2023 års provtagningar påträffades inga abborrhonor med missbildade gonader i något av ovan nämnda områden. Majoriteten av fiskar med sjukdomssymptom fångades i Simpevarp. Endast en sjuk fisk noterades i Kvädöfjärden. Fångsterna i yrkesfisket efter vandrande ål, så kallad blankål, var något högre 2023 än föregående fyra år, men återigen ett av de lägsta sedan journalföringen av detta fiske startades 1972. Under 2023 års undersökning av fauna på mjuka bottnar registrerades totalt 20 arter i Simpevarp och 19 arter i referensområdet Kvädöfjärden när stationer på båda djupen räknas in. Blåmussla följt av östersjömussla var de vanligast förekommande arterna på grunda bottnar både i Simpevarp och Kvädöfjärden. På de djupa bottnarna var den rörbyggande havsborstmasken Pygospio elegans den mest förekommande arten i Simpevarp medan motsvarande i Kvädöfjärden var Östersjömussla.
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Pavlovic, Noel, Barbara Plampin, Gayle Tonkovich, and David Hamilla. Special flora and vegetation of Indiana Dunes National Park. National Park Service, 2024. http://dx.doi.org/10.36967/2302417.
Abstract:
The Indiana Dunes (comprised of 15 geographic units (see Figure 1) which include Indiana Dunes National Park, Dunes State Park, and adjacent Shirley Heinze Land Trust properties) are remarkable in the Midwest and Great Lakes region for the vascular plant diversity, with an astounding 1,212 native plant species in an area of approximately 16,000 acres! This high plant diversity is the result of the interactions among postglacial migrations, the variety of soil substrates, moisture conditions, topography, successional gradients, ?re regimes, proximity to Lake Michigan, and light levels. This richness is all the more signi?cant given the past human alterations of the landscape resulting from logging; conversion to agriculture; construction of transportation corridors, industrial sites, and residential communities; ?re suppression; land abandonment; and exotic species invasions. Despite these impacts, multiple natural areas supporting native vegetation persist. Thus, each of the 15 units of the Indiana Dunes presents up to eight subunits varying in human disturbance and consequently in ?oristic richness. Of the most signi?cant units of the park in terms of number of native species, Cowles Dunes and the Dunes State Park stand out from all the other units, with 786 and 686 native species, respectively. The next highest ranked units for numbers of native species include Keiser (630), Furnessville (574), Miller Woods (551), and Hoosier Prairie (542). The unit with lowest plant richness is Heron Rookery (220), with increasing richness in progression from Calumet Prairie (320), Hobart Prairie Grove (368), to Pinhook Bog (380). Signi?cant natural areas, retaining native vegetation composition and structure, include Cowles Bog (Cowles Dunes Unit), Howes Prairie (Cowles Dunes), Dunes Nature Preserve (Dunes State Park), Dunes Prairie Nature Preserve (Dunes State Park), Pinhook Bog, Furnessville Woods (Furnessville), Miller Woods, Inland Marsh, and Mnoke Prairie (Bailly). Wilhelm (1990) recorded a total of 1,131 native plant species for the ?ora of the Indiana Dunes. This was similar to the 1,132 species recorded by the National Park Service (2014) for the Indiana Dunes. Based on the nomenclature of Swink and Wilhelm (1994), Indiana Dunes National Park has 1,206 native plant species. If we include native varieties and hybrids, the total increases to 1,244 taxa. Based on the nomenclature used for this report?the Flora of North America (FNA 2022), and the Integrated Taxonomic Information System (ITIS 2022)?Indiana Dunes National Park houses 1,206 native vascular plant species. As of this writing (2020), the Indiana Dunes is home to 37% of the species of conservation concern in Indiana (241 out of 624 Indiana-listed species): state extirpated = 10 species, state endangered = 75, and state threatened = 100. Thus, 4% of the state-listed species in the Indiana Dunes are extirpated, 31% endangered, and 41% threatened. Watch list and rare categories have been eliminated. Twenty-nine species once documented from the Indiana Dunes may be extirpated because they have not been seen since 2001. Eleven have not been seen since 1930 and 15 since 1978. If we exclude these species, then there would be a total of 1,183 species native to the Indiana Dunes. Many of these are cryptic in their life history or diminutive, and thus are di?cult to ?nd. Looking at the growth form of native plants, <1% (nine species) are clubmosses, 3% (37) are ferns, 8% (297) are grasses and sedges, 56% (682) are forbs or herbs, 1% (16) are herbaceous vines, <1% (7) are subshrubs (woody plants of herbaceous stature), 5% (60) are shrubs, 1% (11) are lianas (woody vines), and 8% (93) are trees. Of the 332 exotic species (species introduced from outside North America), 65% (219 species) are forbs such as garlic mustard (Alliaria petiolata), 15% (50 species) are graminoids such as phragmites (Phragmites australis ssp. australis), 2% (seven species) are vines such as ?eld bindweed (Convulvulus arvensis), <1% (two species) are subshrubs such as Japanese pachysandra (Pachysandra terminalis), 8% (28 species) are shrubs such as Asian bush honeysuckle (Lonicera spp.), 1% (three species) are lianas such as oriental bittersweet (Celastrus orbiculatus), and 8% (23 species) are trees such as tree of heaven (Ailanthus altissimus). Of the 85 adventive species, native species that have invaded from elsewhere in North America, 14% (11 species) are graminoids such as broom sedge (Andropogon virginicus), 57% (48 species) are forbs such as fall phlox (Phlox paniculata), 5% (six species) are shrubs such as Carolina allspice (Calycanthus floridus), 3% (two species) are subshrubs such as holly leaved barberry (Berberis repens), 1% (one species) is a liana (trumpet creeper (Campsis radicans), 3% two species) are herbaceous vines such as tall morning glory (Ipomoea purpurea), and 17% (15 species) are trees such as American holly (Ilex opaca). A total of 436 species were found to be ?special? based on political rankings (federal and state-listed threatened and endangered species), species with charismatic ?owers, and those that are locally rare.