Journal articles: '352.530 944'

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Mirahmadizadeh, Alireza, Mehdi Sharafi, Jafar Hassanzadeh, and Mozhgan Seif. "Prevalence and risk factors associated with tuberculosis and HIV coinfection in Iran: A multivariate firth logistic regression for rare events." Journal of Infection in Developing Countries 17, no. 12 (December 31, 2023): 1775–81. http://dx.doi.org/10.3855/jidc.17439.

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Introduction: Among the complications caused by HIV infection, tuberculosis (TB) is the most important challenge. The study aimed to determine the predictors of TB and HIV coinfection by using Firth logistic regression analysis. Methodology: This cross-sectional study was conducted on 32,168 HIV-positive patients diagnosed in Iran. The required information was obtained from the national HIV/AIDS surveillance data. Results: The prevalence of TB in HIV patients was 3.2%; the prevalence of TB in males and females was 944 (91.83%) and 84 (8.17%), respectively. Based on results of multivariate Firth logistic regression, male gender OR male/female = 1.91; injecting drug use (IDU) OR YES/NO = 1.46; illiterate or primary groups OR illiterate or primary /university = 2.23; high school group OR high school/ university = 2.24 all increased the risk of TB and HIV coinfection (p < 0.05). Also, having CD4 > 500 [OR CD4 > 500 / < 200 = 0.39], CD4 351-500 [OR351 / < 200 = 0.65], and CD4 200-350 [OR200-350 / < 200 = 0.64] decreased the risk of TB and HIV coinfection (p < 0.001). Conclusions: According to the results of this study, male gender, low education, injecting drug users, and low CD4 count at the time of diagnosis, were significant predictors of TB and HIV coinfection. Therefore, regular and periodic screening programs and linkage to the care and treatment of HIV patients need special attention.

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Viguier, Jérôme, Yvan Coscas, Chantal Touboul, Jean F. Morere, Jean-Yves Blay, Xavier B. Pivot, Christine Lhomel, and François Eisinger. "Knowledge of the French population on colorectal cancer screening: Data from the EDIFICE 3 survey." Journal of Clinical Oncology 31, no. 4_suppl (February 1, 2013): 352. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.352.

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352 Background: In France, following a pilot population-based screening program in 2002-2003, a national organized program targeting 17 million people was progressively implemented from 2005 to 2009. EDIFICE surveys are iterative polls focusing on cancer screening behavior. The EDIFICE 3 survey was conducted in 2011 and partly dedicated to knowledge of the colorectal cancer screening process. Methods: This third nationwide observational study, EDIFICE 3, was conducted via phone interviews among a representative sample of 946 subjects aged between 50 and 74 years, who had never been treated for cancer. 59% of the population declared having undergone colorectal cancer screening (fecal test or colonoscopy). Results: Interviewed about the screening process, 510/946 (54%) of the French population were unaware of the procedure after a positive fecal test and 782/946 (83%) were unaware of how soon a new test should be performed after a negative result. Only 79/946 (8%) were aware of what to do after either a positive or a negative test and 47% in one out of the two cases. 84% of subjects over assessed (by a factor 2 to 10) the probability of having cancer after a positive test. In contrast, 65% were aware of the possibility of a false negative test. Only 3% of our sample know both the right screening agenda (every other year) and the need for a colonoscopy after a positive test. Neither gender, educational level and socio economic level significantly impacted the rate of right answers. Conclusions: This study demonstrates a lack of detailed knowledge on the colorectal cancer screening process in the French national program. This raises the issue of the fairness of the process (an ethical issue) and may be a reason for the current poor uptake (an effectiveness issue). This should be tackled by improving the transmission of information, preferentially via general practitioners, institutional letters sent directly to subjects (in our survey these two media were found to be readily accepted) and lay press.

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Sundaresan, Siddarth, Ranbir Singh, and R. Wayne Johnson. "SILICON CARBIDE “SUPER” JUNCTION TRANSISTORS OPERATING AT 500 °C." Additional Conferences (Device Packaging, HiTEC, HiTEN, and CICMT) 2012, HITEC (January 1, 2012): 000162–66. http://dx.doi.org/10.4071/hitec-2012-wa15.

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1200 V/ 3 mm2 active-area SiC “Super” Junction Transistors (SJTs) display current gains as high as 88 and majority carrier operation up to 250 °C. The SJT operation shifts from purely unipolar to bipolar-mode at temperatures ≥ 300 °C. The leakage currents at a blocking voltage of 1200 V remain below 100 μA, even at 325 °C. Temperature-independent turn-on and turn-off times < 15 ns are measured up to 250 °C. A short-circuit withstand time of 22 μs at VDS=800 V, and a single-pulse avalanche energy of 20.4 mJ are measured. No degradation of the blocking I-V characteristics was observed after a 934 hour repetitive avalanche stress test.

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Buessing, Zachary, Bree Gaffney, Jenna McNelis, Haley F. Linder, Sara M. Tondini, and Joshua C. McCann. "332 Evaluating the Effects of Lactic Acid Adaptation in Beef Cattle Prior to an Acidosis Challenge." Journal of Animal Science 100, Supplement_3 (September 21, 2022): 159. http://dx.doi.org/10.1093/jas/skac247.295.

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Abstract The objective was to determine if a 7-day lactic acid adaptation in cannulated steers affected ruminal fermentation during an acidosis challenge. Steers (n=18; 790 ± 68 kg) were assigned to one of two treatments: control (CON) 500 mL of H2O or 1 mM DL-Lactic acid solution per kg steer BW (LAC). Steers were dosed with treatments via the cannula prior to feeding for seven days during the adaptation period. The adaptation diet consisted of 25% corn silage, 30% grass hay, 15% dry distillers grains, 25% dry rolled corn, 5% molasses and 10% supplement. To induce acidosis, steers were fasted for 24 hours and subsequently fed a high concentrate diet consisting of 15% corn silage, 15% dry distillers grains, 55% high moisture corn, 5% molasses, 10% supplement. Rumen fluid was collected throughout the acidosis challenge to measure fermentation characteristics including rumen pH, redox, ammonia, volatile fatty acids, and lactic acid. Data were analyzed using the MIXED procedure of SAS 9.4 with a repeated measures analysis. Dry matter intake was not affected (P ≥ 0.65) by treatment before or after the acidosis challenge. A treatment × time interaction was not observed (P = 0.83) for ruminal pH, but pH was affected (P < 0.01) by time and remained between 5.6 and 5.0 for about 14 hours during the challenge. A treatment × hour interaction tended (P = 0.08) to be observed for lactate; LAC had a greater concentration than CON at hour 14 during the challenge. However, a treatment × hour interaction was not detected (P ≥ 0.38) for ammonia, volatile fatty acids, fecal pH and redox potential. In conclusion, these results indicate that a 7-day lactic acid adaption at 1 mM per kg BW did not affect ruminal fermentation characteristics during an acidosis challenge.

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Veselovskii, Igor, Philippe Goloub, Thierry Podvin, Didier Tanre, Arlindo da Silva, Peter Colarco, Patricia Castellanos, et al. "Characterization of smoke and dust episode over West Africa: comparison of MERRA-2 modeling with multiwavelength Mie–Raman lidar observations." Atmospheric Measurement Techniques 11, no. 2 (February 16, 2018): 949–69. http://dx.doi.org/10.5194/amt-11-949-2018.

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Abstract. Observations of multiwavelength Mie–Raman lidar taken during the SHADOW field campaign are used to analyze a smoke–dust episode over West Africa on 24–27 December 2015. For the case considered, the dust layer extended from the ground up to approximately 2000 m while the elevated smoke layer occurred in the 2500–4000 m range. The profiles of lidar measured backscattering, extinction coefficients, and depolarization ratios are compared with the vertical distribution of aerosol parameters provided by the Modern-Era Retrospective Analysis for Research and Applications, version 2 (MERRA-2). The MERRA-2 model simulated the correct location of the near-surface dust and elevated smoke layers. The values of modeled and observed aerosol extinction coefficients at both 355 and 532 nm are also rather close. In particular, for the episode reported, the mean value of difference between the measured and modeled extinction coefficients at 355 nm is 0.01 km−1 with SD of 0.042 km−1. The model predicts significant concentration of dust particles inside the elevated smoke layer, which is supported by an increased depolarization ratio of 15 % observed in the center of this layer. The modeled at 355 nm the lidar ratio of 65 sr in the near-surface dust layer is close to the observed value (70 ± 10) sr. At 532 nm, however, the simulated lidar ratio (about 40 sr) is lower than measurements (55 ± 8 sr). The results presented demonstrate that the lidar and model data are complimentary and the synergy of observations and models is a key to improve the aerosols characterization.

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Delgadillo Guzmán, Leonor Guadalupe, Francisco José Argüello Zepeda, and Leonor González Villanueva. "Construcción de la EVIEES: Prácticas violentas por género en Educación Superior." Revista del Centro de Investigación de la Universidad la Salle 12, no. 46 (March 23, 2017): 39–78. http://dx.doi.org/10.26457/recein.v12i46.859.

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Este trabajo tuvo como objetivo construir una escala psicométrica sobre violencia escolar entre estudiantes y estudiantes-profesores de educación pública superior para determinar las prácticas violentas por género, utilizando el modelo desarrollado por Delgadillo (2010, 2012). Es un estudio cuantitativo, transversal, exploratorio. Se trabajó con 744 estudiantes universitarios, 354 hombres, 388 mujeres; se obtuvieron valores estadísticos pertinentes: adecuación muestral KMO de .940; esfericidad de Bartlett de .000; valores de comunalidad superiores a .500; varianza total explicada de 44.15%, 64 reactivos distribuidos en 8 factores; confiabilidad de α de Cronbach de .946; arrojando ocho indicadores: F1, física-psicológica; F2, desvalorización-control; F3, discriminación; F4, arbitrariedad; F5, indiferencia-desprecio; F6, desaprobación-rechazo; F7, abuso; F8, calumnia. Los resultados indican que las medias por grupo, según el sexo, los hombres son quienes presentan significativamente más interacciones violentas y encabezan los registros de violencia a comparación de las mujeres, independientemente del nivel escolar. Disponer de una herramienta psicométrica técnicamente sólida es la mayor contribución de este trabajo, sobretodo hablando de un tema escasamente abordado, la violencia horizontal y vertical en educación púbica superior. Esto significa que las IES (Instituciones de Educación Superior) junto con el sector de la administración de justicia, podrán hacer uso de esta herramienta, EVIESS para documentar evidencia objetiva en caso de queja o denuncia de violencia escolar por pares o no pares, para la protección de la garantía establecida en el artículo 3º, fracción II, inciso “c” de la Constitución Política de los Estados Unidos Mexicanos.

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Karaca, Melek, and Oktay Bektas. "Self-Regulation Scale for Science: A Validity and Reliability Study." International Journal on Social and Education Sciences 4, no. 2 (May 26, 2022): 236–56. http://dx.doi.org/10.46328/ijonses.302.

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Self-regulation is important at every stage of the education process and must be measured accurately in order to know at what students’ levels are. The aim of this study is to develop a scale that is able to validly and reliably determine the self-regulation levels of secondary school students regarding science. The study uses the survey design, a quantitative research method. The sample of the research consists of 500 students enrolled in three secondary schools in Kayseri Province’s Melikgazi district during 2018 spring semester. While preparing the scale, which was developed based on social cognitive theory, a literature review was conducted, expert opinions were sought, and a pilot study was conducted to test the suitability of the items. Exploratory and confirmatory factor analyses (EFA and CFA) were performed to ensure the construct validity. As a result of the EFA, a structure consisting of 26 questions was obtained whose three factors explain 48% of the variance. This structure was confirmed through CFA, which was conducted on the data obtained from a sample different than the one used in the EFA. Cronbach’s alpha of reliability for the scale was calculated as .940. As a result, a valid and reliable scale for science education based on social cognitive theory and Zimmerman’s self-regulation model was obtained that is simple enough that middle school student can understand it.

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Zhang, Pingping, Yantong Sun, Guobing Shi, Yin Sui, Qiuying Li, Yunbiao Tang, and Jingkai Gu. "Quantification of Niacin and Its Metabolite Nicotinuric Acid in Human Plasma by LC-MS/MS: Application to a Clinical Trial of a Fixed Dose Combination Tablet of Niacin Extended-Release/Simvastatin (500 mg/10 mg) in Healthy Chinese Volunteers." International Journal of Analytical Chemistry 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/212437.

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Our paper aimed to develop rapid, sensitive, and specific LC-MS/MS method for the quantification of niacin (NA) and its metabolite nicotinuric acid (NUA) in human plasma. Following protein precipitation with acetonitrile, the NA, NUA, and internal standard (5-fluorouracil) were separated on a Zorbax 300SB-C8column (250 mm × 4.6 mm, 5 μm) with a mobile phase consisting of methanol-2 mM ammonium acetate (3 : 97, v/v) at a flow rate of 1 mL/min (split 1 : 1). A tandem mass spectrometer equipped with electrospray ionization source was used as the detector and operated in negative ion mode. The linear concentration ranges of the calibration curves were 5–800 ng/mL for NA and NUA. The intra-assay RSD for quality control (QC) samples were from 5.0% to 8.7% for NA, and 5.5% to 7.6% for NUA. The interassay RSD for QC samples were from 2.8% to 9.4% for NA, and 3.7% to 5.8% for NUA. The relative errors for QC samples were from −2.2% to 2.3% for NA, and −0.6% to 3.2% for NUA. The method was successfully applied to the investigation of the pharmacokinetic profiles of NA, NUA in human after single dose administration of Niacin extended-release/Simvastatin tablet (500 mg/10 mg).

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Ghafouri-Fard, Soudeh, Atefe Abak, Bashdar Mahmud Hussen, Mohammad Taheri, and Guive Sharifi. "The Emerging Role of Non-Coding RNAs in Pituitary Gland Tumors and Meningioma." Cancers 13, no. 23 (November 28, 2021): 5987. http://dx.doi.org/10.3390/cancers13235987.

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Long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs) are non-coding transcripts which are involved in the pathogenesis of pituitary gland tumors. LncRNAs that participate in the pathogenesis of pituitary gland tumors mainly serve as sponges for miRNAs. CLRN1-AS1/miR-217, XIST/miR-424-5p, H19/miR-93a, LINC00473/miR-502-3p, SNHG7/miR-449a, MEG8/miR-454-3p, MEG3/miR-23b-3p, MEG3/miR-376B-3P, SNHG6/miR-944, PCAT6/miR-139-3p, lncRNA-m433s1/miR-433, TUG1/miR-187-3p, SNHG1/miR-187-3p, SNHG1/miR-302, SNHG1/miR-372, SNHG1/miR-373, and SNHG1/miR-520 are identified lncRNA/miRNA pairs that are involved in this process. Hsa_circ_0001368 and circOMA1 are two examples of circRNAs that contribute to the pathogenesis of pituitary gland tumors. Meanwhile, SNHG1, LINC00702, LINC00460, and MEG3 have been found to partake in the pathogenesis of meningioma. In the current review, we describe the role of non-coding RNAs in two types of brain tumors, i.e., pituitary tumors and meningioma.

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Lei, Qi, Runfeng Zhang, Xi Zou, Aiping Zhou, and Chun-Xia Du. "Multiple primary cancers in patients with gastric cancer: A retrospective study in China National Cancer Center." Journal of Clinical Oncology 38, no. 4_suppl (February 1, 2020): 337. http://dx.doi.org/10.1200/jco.2020.38.4_suppl.337.

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337 Background: Gastric cancer (GC) is common in China. With the total incidence of cancer keeping rising in China, the occurrence of multiple primary cancers with GC is growing. Early detection and diagnosis of second or more primary cancers are vital for patients’ survival. Methods: Patients with multiple primary cancers containing gastric adenocarcinoma treated in China National Cancer Center from January 2010 to December 2017 were included. A 6-month interval was used to separate synchronous and metachronous cancers (according to IARC/IACR criteria). Results: 479 patients met the criteria were included, with 452 (94.4%), 24 (5.0%), 3 (0.6%) patients having two, three or more primary cancer sites respectively, contributing a total of 510 cancer sites besides stomach (Table). Malignancies at 257 (50.4%) sites occurred with GC synchronously, while 253 (49.6%) occurred metachronously. The median age at the diagnosis of first cancer was 59 (interquartile range [IQR], 53-66) years. The median interval between the diagnosis of first primary cancer and metachronous second one was 50.3 (IQR, 23.7-97.0) months. Cancers outside gastrointestinal (GI) tract were more likely to occur with GC metachronously, while GI tract cancers were more likely to occur synchronously (χ²=55.36, p<0.001). Out of 479 patients, there were 352 (73.6%) male and 127 (26.4%) female. The most common associated cancer was esophagus cancer (142, 40.3%) in male, and breast cancer (31, 25.4%) in female. 236 (49.8%) patients were current smokers or ex-smokers, and 190 (40.1%) were regular alcohol consumers. 110 (23.2%) had first-degree relative cancer family history, with 84 (17.7%) having GI tract cancer family history. Conclusions: GI tract including esophagus and colorectum should be carefully scrutinized during GC peri-operation period. Further genetic research is warranted to explore the potential pathogenesis of multiple primary cancers.[Table: see text]

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Demidov, Valery Anatolyevich. "Corrigendum to: V. A. Sokolov, “On the Existence Problem of Finite Bases of Identities in the Algebras of Recursive Functions”, Modeling and analysis of information systems, vol. 27, no. 3, pp. 304-315, 2020. DOI: https://doi.org/10.18255/1818-1015-2020-3-304-315." Modeling and Analysis of Information Systems 27, no. 4 (December 20, 2020): 510–11. http://dx.doi.org/10.18255/1818-1015-2020-4-510-511.

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The author regrets that in the original list the references [3] and [4] are in the wrong places and they should be rearranged. In addition, [3] has the wrong article title. The corrected reference list is shown below.The author would like to apologize for an inconvenience caused.References[1] A. I. Mal'tsev, “Constructive algebras I”, Russian Mathematical Surveys, vol. 16, no. 3, pp. 77-129, 1961.[2] A. I. Mal'tsev, Algoritmy i rekursivnye funktsii. Moscow: Nauka, 1965, In Russian.[3] R. M. Robinson, “Primitive recursive functions”, Bulletin of the American Mathematical Society, vol. 53, no. 10,pp. 925-942, 1947.[4] J. Robinson, “General recursive functions”, Proceedings of the American Mathematical Society, vol. 1, no. 6,pp. 703-718, 1950.[5] V. A. Sokolov, “Ob odnom klasse tozhdestv v algebre Robinsona”, in 14-ya Vsesoyuznaya algebraicheskaya konferentsiya: tezisy dokladov, In Russian, vol. 2, Novosibirsk, 1977, pp. 123-124.[6] P. M. Cohn, Universal Algebra. New York, Evanston, and London: Harper & Row, 1965.[7] A. Robinson, “Equational logic for partial functions under Kleene equality: a complete and an incomplete set of rules”, The Journal of Symbolic Logic, vol. 54, no. 2, pp. 354-362, 1989.

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Deodhar, A., R. Ranza, F. Ganz, T. Gao, J. Anderson, and A. Ostor. "OP0233 EFFICACY AND SAFETY OF UPADACITINIB IN PATIENTS WITH PSORIATIC ARTHRITIS AND AXIAL INVOLVEMENT." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 143–44. http://dx.doi.org/10.1136/annrheumdis-2021-eular.439.

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Background:Patients (pts) with psoriatic arthritis (PsA) and axial involvment exhibit greater disease activity and quality of life impairments compared with those without axial involvment.Objectives:To characterize PsA pts with and without axial involvement and compare efficacy of UPA vs placebo (PBO) in PsA pts with axial involvement.Methods:In SELECT-PsA 1 (NCT03104400; N=1705, non-biologic DMARD IR) and SELECT-PsA 2 (NCT03104374; N=642, biologic DMARD IR), pts with active PsA (≥3 swollen and ≥3 tender joints), active or historical psoriasis, and on ≤2 non-biologic DMARDs were randomized to once daily UPA 15 mg, UPA 30 mg, adalimumab 40 mg every other week (SELECT-PsA 1 only), or PBO. Efficacy was assessed in pts with axial involvement (diagnosed by investigators based on totality of information) pooled from the 2 studies. Assessments included change from BL in BASDAI, BASDAI Q2 (neck/back/hip pain) and Q3 (joint swelling/pain), and the AS Disease Activity Score (ASDAS-CRP), and percentage with BASDAI 50 response, ASDAS inactive disease (ID), ASDAS low disease activity (LDA), ASDAS major improvement (MI), and ASDAS clinically important improvement (CII). Uveitis and inflammatory bowel disease (IBD) adverse events were reviewed. Data on 24-week PBO-controlled period are presented.Results:Prevalence of axial involvment was 31.3% in SELECT-PsA 1 and 34.2% in SELECT-PsA 2 (Table). Treatment with UPA 15 mg and 30 mg resulted in significantly greater improvements from BL in the BASDAI, BASDAI Q2 (neck/back/hip pain) and Q3 (joint swelling/pain) and ASDAS-CRP at weeks 12 and 24 vs PBO (Figure). Similarly, significantly higher percentages of pts on UPA 15 mg and 30 mg achieved BASDAI 50, ASDAS ID, LDA, MI, and CII at weeks 12 and 24 vs PBO (Figure). One pt on UPA 30 mg had incident uveitis, and no IBD was reported on UPA.Table 1.Demographics and Baseline CharacteristicsSELECT-PsA 1SELECT-PsA 2Parameter, mean (SD)With Psoriatic Spondylitis(n=534)Without Psoriatic Spondylitis(n=1170)Pvalue*With Psoriatic Spondylitis(n=219)Without Psoriatic Spondylitis(n=421)Pvalue*BMI (kg/m2)29.9 (6.5)30.5 (6.9).081031.6 (8.0)31.3 (6.9).6226TJC6821.6 (15.1)19.2 (13.5).002227.5 (18.0)23.3 (16.2).0027SJC6611.7 (9.4)11.0 (7.9).118412.9 (9.2)11.7 (8.7).0804Physician’s Global Assessment (NRS 0–10)6.7 (1.6)6.5 (1.7).04376.6 (1.8)6.5 (1.7).1897HAQ-DI1.2 (0.6)1.1 (0.6).01701.2 (0.6)1.2 (0.7).2049n=531n=1164n=218n=416Presence of dactylitis, n (%)†188 (35.2)328 (28.0).002869 (31.5)100 (23.8).0348Presence of enthesitis, n(%)‡432 (80.9)884 (75.6).0147189 (86.3)337 (80.0).0125ASDAS–CRP3.4 (0.9)3.1 (1.0)<.00013.3 (1.0)3.2 (1.1).1032n=530n=1161n=217n=416BASDAI5.8 (2.0)5.3 (2.2)<.00016.2 (2.2)5.8 (2.2).0673n=530n=1161n=217n=416Morning Stiffness Duration (NRS 0–10; BASDAI Q6)5.0 (3.0)4.7 (3.0).03685.6 (3.2)5.1 (3.0).0454n=530n=1161n=217n=416Patient’s Assessment of Inflammatory Neck, Back, or Hip Pain (NRS 0–10; BASDAI Q2)5.8 (2.7)4.6 (3.2)<.00016.4 (2.8)5.4 (3.1).0001n=530n=1161n=217n=416*Calculated by t-test for continuous variables and chi-square test for categorical values. Bolded if <0.05.Defined as †LDI>0 and ‡total enthesitis count >0Conclusion:PsA pts with axial involvement had higher BL disease burden compared with those without axial involvement. UPA was efficacious in treating axial symptoms in pts with psoriatic spondylits.References:[1]van der Heijde D, et al. Lancet. 2019;394(10214):2108-2117.Acknowledgements:Abbvie funded the study. AbbVie participated in study design, research, analysis, data collection, interpretation of the data, reviewing, and approval. All authors had access to the relevant data and participated in the drafting, review, and approval of the abstract. No honoraria or payments were made for authorship. Medical writing support was provided by M Mehta, and J Matsuura of ICON plc (North Wales, PA) and was funded by AbbVie.Disclosure of Interests:Atul Deodhar Speakers bureau: Novartis and Pfizer, Consultant of: Novartis, Pfizer, AbbVie, Eli Lilly, UCB Pharma, GlaxoSmithKline, Galapagos, Janssen, Boehringer Ingelheim and Celgene, Grant/research support from: Novartis, Pfizer, AbbVie, Eli Lilly, UCB Pharma, GlaxoSmithKline, R Ranza Speakers bureau: AbbVie, Janssen, Lilly, Novartis, and Pfizer, Consultant of: AbbVie, Janssen, Lilly, Novartis, and Pfizer, Grant/research support from: AbbVie, Janssen, Fabiana Ganz Shareholder of: AbbVie, Employee of: AbbVie, Tianming Gao Shareholder of: AbbVie, Employee of: AbbVie, Jaclyn Anderson Shareholder of: AbbVie, Employee of: AbbVie, Andrew Ostor Consultant of: AbbVie, BMS, Roche, Janssen, Lilly, Novartis, Pfizer, UCB, Gilead, and Paradigm

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Marichev, V. N., V. A. Yushkov, N. V. Balugin, and D. A. Bochkovsky. "Результаты эксперимента по совместному лидарному и шар-баллоному зондированию тропосферы и стратосферы." Вестник КРАУНЦ. Физико-математические науки 46, no. 1 (March 8, 2024): 165–72. http://dx.doi.org/10.26117/2079-6641-2024-46-1-165-172.

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The current problem of climate change requires studying changes in the composition and properties of the atmosphere, affecting its radiation balance. Obtaining knowledge in this direction is possible through regular measurements of climate-forming components and atmospheric characteristics and their subsequent analysis. There are contact and remote methods and means of sensing the atmosphere at its different altitude levels, including aerological, aircraft, satellite, lidar and rocket. This paper proposes a technology for monitoring the aerosol component based on remote (lidar) and contact (aerological) optical sounding. The results of simultaneous remote (lidar) and direct (sonde) measurements of the vertical distribution of aerosol loading in the troposphere and stratosphere, carried out on January 27-30, 2022 and March 15-16, 2023 in Tomsk, are presented. The purpose of the experiment was to conduct joint lidarballoon measurements and validate aerosol backscatter profiles in the upper troposphere and stratosphere to create an all-weather lidar-balloon monitoring system of spatiotemporal and microphysical characteristics of aerosol. Good agreement is demonstrated in the obtained vertical profiles of the value of the backscatter ratio R(H) for close wavelengths (528 and 532 nm for the aerosol backscatter sonde and lidar, respectively). To restore the microphysical parameters of an aerosol during joint lidar-balloon experiments, the possibility of expanding 2-wave (355 and 532 nm) lidar measurements with an additional set of wavelengths (470, 850, 940 nm) using an optical balloon aerosol sonde was shown. Актуальная проблема климатических изменений требует изучения изменения состава и свойств атмосферы, влияющих на ее радиационный баланс. Получение знаний в данном направлении возможно на основе проведения регулярных измерений климатообразующих компонент и характеристик атмосферы и их последующего анализа. Существуют контактные и дистанционные методы и средства зондирования атмосферы на ее разных высотных уровнях, включая аэрологические, самолетные, спутниковые, лидарные и ракетные. В настоящей работе предложена технология мониторинга аэрозольной компоненты на основе дистанционного (лидарного) и контактного (аэрологического) оптического зондирования. Приводятся результаты одновременных дистанционных (лидарных) и прямых (зондовых) измерений вертикального распределения аэрозольного наполнения тропосферы и стратосферы, осуществленных 27-30 января 2022 и 15-16 марта 2023 в Томске. Целью эксперимента было проведения совместных лидарно-балонных измерений и валидация аэрозольных профилей обратного рассеяния в верхней тропосфере и стратосфере для создания всепогодной системы лидарно-баллонного мониторинга пространственно-временных и микрофизических характеристик аэрозоля. Продемонстрировано хорошее согласие в полученных вертикальных профилях значения отношения обратного рассеяния R(H) для близких длин волн (528 и 532 нм для аэрозольного зонда обратного рассеяния и лидара, соответственно). Для восстановления микрофизических параметров аэрозоля при проведении совместных лидарно-баллонных экспериментов показана возможность расширения 2-х волновых (355 и 532 нм) лидарных измерений дополнительным набором длин волн(470, 850, 940 нм) с помощью оптического баллонного аэрозольного зонда.

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Hemmige, Vagish, Cesar Arias, Siavash Pasalar, and Thomas P. Giordano. "934. Incidence of Skin and Soft-tissue Infection in People Living With HIV in a Large Urban Public Health Care System in Houston, Texas, 2009–2014." Open Forum Infectious Diseases 5, suppl_1 (November 2018): S32. http://dx.doi.org/10.1093/ofid/ofy209.074.

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Abstract Background Skin and soft-tissue infections (SSTIs) disproportionately impact patients with HIV. Recent declines have been noted in the incidence of SSTIs in the non-HIV population. We set out to study the epidemiology and microbiology of SSTIs in a population of 8,597 patients followed for HIV primary care in a large urban county system from January 1, 2009 to December 31, 2014. Methods SSTIs were identified from the electronic medical record (EMR) by the use of ICD-9 billing codes. Charts were reviewed to confirm the diagnosis of acute SSTI and abstract culture and susceptibility data. We calculated yearly SSTI incidence using Poisson regression with clustering by patient. Results 2202 SSTIs were identified. Of 503 (22.8%) cultured SSTIs, 332 (66.0%) included S. aureus as a pathogen, of which 287/332 (86.4%) featured S. aureus as the sole pathogen. Of S. aureus isolates with susceptibilities, 231/331 (69.8%) were methicillin-resistant, and the proportion did not vary by year (P = NS). The observed incidence of SSTI was 78.0 per 1,000 person-years (95% CI 72.9–83.4) and declined from 96.0 infections per 1,000 person-years in 2009 to 56.5 infections per 1,000 person years in 2014 (P < 0.001). Other significant predictors of SSTI incidence in both univariate as well as multivariate analysis included CD4 count, viral load, and being a Spanish-speaking Hispanic. Conclusion Although SSTI rates in a large urban HIV-infected outpatient cohort declined approximately 40% between 2009 and 2014, SSTIs remain a significant problem. Disclosures C. Arias, Merck & Co., Inc.: Grant Investigator, Research support. MeMed: Grant Investigator, Research support. Allergan: Grant Investigator, Research support

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Diao, Yaqin, Hengpeng Li, Sanyuan Jiang, and Xinyan Li. "Effects of Changing Fertilization since the 1980s on Nitrogen Runoff and Leaching in Rice–Wheat Rotation Systems, Taihu Lake Basin." Water 12, no. 3 (March 21, 2020): 886. http://dx.doi.org/10.3390/w12030886.

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The nitrogen (N) loss associated with intensive agricultural activities is a significant cause of eutrophication and algal blooms in freshwater ecosystems. Taihu Lake has experienced serious surface water quality deterioration and eutrophication problems since the 1980s. The objective of this study is to examine the effect of fertilization changes since the 1980s on the N loss with runoff and leaching in the rice–wheat cropping rotation system. According to the results published in the literature since the 1980s, we set up four fertilization scenarios—N1980s: a fertilization rate of 350 kg N·ha−1·year−1 with 30% in manure fertilization to simulate fertilization in the 1980s; NA1990s: a fertilization rate of 500 kg N·ha−1·year−1 with 10% in manure fertilization to simulate fertilization in the early 1990s; NL1990s: fertilization rate of 600 kg N·ha−1·year−1 with 10% in manure fertilization to simulate fertilization in the late 1990s; and N2000s: fertilization rate of 550 kg N·ha−1·year−1 with all chemicals to simulate fertilization in the 2000s. Then, we calibrated and validated the DNDC (denitrification–decomposition) model through field experiments in two rice–wheat rotation seasons from November 2011 to October 2013 and simulated the N loss with runoff and leaching since the 1980s. The results show that N losses with leaching in the four periods (N 1980s, NA1990s, NL1990s, and N2000s) were 5.2 ± 2.1, 9.4 ± 3.2, 14.4 ± 4.6 and 13.5 ± 4.6 kg N·ha−1·year−1, respectively. N losses with surface runoff were 7.9 ± 3.9, 18.3 ± 7.2, 25.4 ± 10.2, and 26.5 ± 10.6 kg N·ha−1·year−1, respectively. The total N loss through runoff and leaching showed an increasing trend from 1980 to the late 1990s, when it reached its peak. The increase in N export to water due to fertilizer application occurs mainly during the rainy season from March to August, and especially from June to August, when rainfall events and intensive rice fertilization activities are frequent. After the 1990s, when the fertilizer rate was above 500 kg N·ha−1·year−1, the crop yields no longer increased significantly, which indicates that the optimized fertilization rate to balance crop yields and N loss to water is lower than 500 kg N·ha−1·year−1. The increase in fertilizer use has been unnecessary since the early 1990s, and at least about 30% of the N loss could have been prevented without reducing crop yields.

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Joswig, Holger, Jonathan C. Lau, Mahmoud Abdallat, Andrew G. Parrent, Keith W. MacDougall, Richard S. McLachlan, Jorge G. Burneo, and David A. Steven. "Stereoelectroencephalography Versus Subdural Strip Electrode Implantations: Feasibility, Complications, and Outcomes in 500 Intracranial Monitoring Cases for Drug-Resistant Epilepsy." Neurosurgery 87, no. 1 (May 1, 2020): E23—E30. http://dx.doi.org/10.1093/neuros/nyaa112.

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Abstract BACKGROUND Both stereoelectroencephalography (SEEG) and subdural strip electrodes (SSE) are used for intracranial electroencephalographic recordings in the invasive investigation of patients with drug-resistant epilepsy. OBJECTIVE To compare SEEG and SSE with respect to feasibility, complications, and outcome in this single-center study. METHODS Patient characteristics, periprocedural parameters, complications, and outcome were acquired from a pro- and retrospectively managed databank to compare SEEG and SSE cases. RESULTS A total of 500 intracranial electroencephalographic monitoring cases in 450 patients were analyzed (145 SEEG and 355 SSE). Both groups were of similar age, gender distribution, and duration of epilepsy. Implantation of each SEEG electrode took 13.9 ± 7.6 min (20 ± 12 min for each SSE; P < .01). Radiation exposure to the patient was 4.3 ± 7.7 s to a dose area product of 14.6 ± 27.9 rad*cm2 for SEEG and 9.4 ± 8.9 s with 21 ± 22.4 rad*cm2 for SSE (P < .01). There was no difference in the length of stay (12.2 ± 7.2 and 12 ± 6.3 d). The complication rate was low in both groups. No infections were seen in SEEG cases (2.3% after SSE). The rate of hemorrhage was 2.8% for SEEG and 1.4% for SSE. Surgical outcome was similar. CONCLUSION SEEG allows targeting deeply situated foci with a non-inferior safety profile to SSE and seizure outcome comparable to SSE.

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Langer-Gould, A., KB Albers, SK Van Den Eeden, and LM Nelson. "Autoimmune diseases prior to the diagnosis of multiple sclerosis: a population-based case-control study." Multiple Sclerosis Journal 16, no. 7 (May 12, 2010): 855–61. http://dx.doi.org/10.1177/1352458510369146.

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The objective of this study was to determine whether patients with multiple sclerosis (MS) are more likely to have other autoimmune disorders particularly prior to the diagnosis of MS. We conducted a population-based case—control study of patients enrolled in the Northern California Kaiser Permanente Medical Care Program. Electronic clinical records through 2005 were used to ascertain incident and prevalent MS cases and identify the presence and timing of 44 other diagnoses. Controls were matched 5:1 for gender, age, and Kaiser membership characteristics. We identified 5296 MS cases (including 924 diagnosed between 2001 and 2004) and 26,478 matched controls. Prior to MS diagnosis, cases were more likely than controls to have uveitis (OR = 3.2, 95%; CI 1.7—5.7), inflammatory bowel disease (IBD, OR = 1.7; 95%CI 1.2—2.5), and Bell’s palsy (OR = 3.2; 95%CI 1.2—8.3). Cases were also more likely to develop Guillain— Barré syndrome (GBS, OR = 5.0; 95%CI 1.6—15.4) and bullous pemphigoid (OR = 6.7; 95%CI 1.5—29.9). Cases were not more likely than controls to have or to develop rheumatoid arthritis, lupus or thyroiditis. MS may share environmental triggers, genetic susceptibilities and/or alterations in immune homeostasis with IBD and uveitis, but not with other autoimmune disorders.

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Max, Wendy, Dorothy P. Rice, Eric Finkelstein, Robert A. Bardwell, and Steven Leadbetter. "The Economic Toll of Intimate Partner Violence Against Women in the United States." Violence and Victims 19, no. 3 (June 2004): 259–72. http://dx.doi.org/10.1891/vivi.19.3.259.65767.

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This study provides estimates of the economic cost of intimate partner violence perpetrated against women in the US, including expenditures for medical care and mental health services, and lost productivity from injury and premature death. The analysis uses national survey data, including the National Violence Against Women Survey and the Medical Expenditure Panel Survey, to estimate costs for 1995. Intimate partner violence against women cost $5.8 billion dollars (95% confidence interval: $3.9 to $7.7 billion) in 1995, including $320 million ($136 to $503 million) for rapes, $4.2 billion ($2.4 to $6.1 billion) for physical assault, $342 million ($235 to $449 million) for stalking, and $893 million ($840 to $946 million) for murders. Updated to 2003 dollars, costs would total over $8.3 billion. Intimate partner violence is costly in the US. The potential savings from efforts to reduce this violence are substantial. More comprehensive data are needed to refine cost estimates and monitor costs over time.

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Weng, Haiyong, Ya Tian, Na Wu, Xiaoling Li, Biyun Yang, Yiping Huang, Dapeng Ye, and Renye Wu. "Development of a Low-Cost Narrow Band Multispectral Imaging System Coupled with Chemometric Analysis for Rapid Detection of Rice False Smut in Rice Seed." Sensors 20, no. 4 (February 22, 2020): 1209. http://dx.doi.org/10.3390/s20041209.

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Spectral imaging is a promising technique for detecting the quality of rice seeds. However, the high cost of the system has limited it to more practical applications. The study was aimed to develop a low-cost narrow band multispectral imaging system for detecting rice false smut (RFS) in rice seeds. Two different cultivars of rice seeds were artificially inoculated with RFS. Results have demonstrated that spectral features at 460, 520, 660, 740, 850, and 940 nm were well linked to the RFS. It achieved an overall accuracy of 98.7% with a false negative rate of 3.2% for Zheliang, and 91.4% with 6.7% for Xiushui, respectively, using the least squares-support vector machine. Moreover, the robustness of the model was validated through transferring the model of Zheliang to Xiushui with the overall accuracy of 90.3% and false negative rate of 7.8%. These results demonstrate the feasibility of the developed system for RFS identification with a low detecting cost.

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Emmerick, Isabel Cristina Martins, Mônica Rodrigues Campos, Debora Castanheira, Jessica Muzy, Aline Marques, Luisa Arueira Chaves, and Mario Jorge Sobreira da Silva. "Lung Cancer Screening in Brazil Comparing the 2013 and 2021 USPSTF Guidelines." JAMA Network Open 6, no. 12 (December 11, 2023): e2346994. http://dx.doi.org/10.1001/jamanetworkopen.2023.46994.

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ImportanceIt is estimated that, from 2023 to 2025, lung cancer (LC) will be the second most frequent cancer in Brazil, but the country does not have an LC screening (LCS) policy.ObjectiveTo compare the number of individuals eligible for screening, 5-year preventable LC deaths, and years of life gained (YLG) if LC death is averted by LCS, considering 3 eligibility strategies by sociodemographic characteristics.Design, Setting, and ParticipantsThis comparative effectiveness research study assessed 3 LCS criteria by applying a modified version of the LC-Death Risk Assessment Tool (LCDRAT) and the LC-Risk Assessment Tool (LCRAT). Data are from the 2019 Brazilian National Household Survey. Participants included ever-smokers aged 50 to 80 years. Data analysis was performed from February to May 2023.ExposuresExposures included ever-smokers aged 50 to 80 years, US Preventive Services Task Force (USPSTF) 2013 guidelines (ever-smokers aged 55 to 80 years with ≥30 pack-years and &lt;15 years since cessation), and USPSTF 2021 guidelines (ever-smokers aged 50 to 80 years with 20 pack-years and &lt;15 years since cessation).Main Outcomes and MeasuresThe primary outcomes were the numbers of individuals eligible for LCS, the 5-year preventable deaths attributable to LC, and the number of YLGs if death due to LC was averted by LCS.ResultsIn Brazil, the eligible population for LCS was 27 280 920 ever-smokers aged 50 to 80 years (13 387 552 female [49.1%]; 13 249 531 [48.6%] aged 50-60 years; 394 994 Asian or Indigenous [1.4%]; 3 111 676 Black [11.4%]; 10 942 640 Pardo [40.1%]; 12 830 904 White [47.0%]; 12 428 536 [45.6%] with an incomplete middle school education; and 12 860 132 [47.1%] living in the Southeast region); 5 144 322 individuals met the USPSTF 2013 criteria for LCS (2 090 636 female [40.6%]; 2 290 219 [44.5%] aged 61-70 years; 66 430 Asian or Indigenous [1.3%]; 491 527 Black [9.6%]; 2 073 836 Pardo [40.3%]; 2 512 529 [48.8%] White; 2 436 221 [47.4%] with an incomplete middle school education; and 2 577 300 [50.1%] living in the Southeast region), and 8 380 279 individuals met the USPSTF 2021 LCS criteria (3 507 760 female [41.9%]; 4 352 740 [51.9%] aged 50-60 years; 119 925 Asian or Indigenous [1.4%]; 839 171 Black [10.0%]; 3 330 497 Pardo [39.7%]; 4 090 687 [48.8%] White; 4 022 784 [48.0%] with an incomplete middle school education; and 4 162 070 [49.7%] living in the Southeast region). The number needed to screen to prevent 1 death was 177 individuals according to the USPSTF 2013 criteria and 242 individuals according to the USPSTF 2021 criteria. The YLG was 23 for all ever-smokers, 19 for the USPSTF 2013 criteria, and 21 for the USPSTF 2021 criteria. Being Black, having less than a high school education, and living in the North and Northeast regions were associated with increased 5-year risk of LC death.Conclusions and RelevanceIn this comparative effectiveness study, USPSTF 2021 criteria were better than USPSTF 2013 in reducing disparities in LC death rates. Nonetheless, the risk of LC death remained unequal, and these results underscore the importance of identifying an appropriate approach for high-risk populations for LCS, considering the local epidemiological context.

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Az-zahra, Nindya, Lestari Lestari, and Havidh Pramadika. "PENGARUH PENAMBAHAN LARUTAN SURFAKTAN PADA LARUTAN POLIMER TERHADAP TEGANGAN ANTARMUKA DAN VISKOSITAS." PETRO:Jurnal Ilmiah Teknik Perminyakan 8, no. 2 (July 3, 2019): 71. http://dx.doi.org/10.25105/petro.v8i2.4779.

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This laboratory research uses surfactant X concentrations 0.05%, 0.1%, 0.3%, 0.5%, and 1%; with polymer P40 concentrations 500 ppm, 750 ppm, 1000 ppm, 1250 ppm, 1500 ppm, and 2000 ppm. The purpose of this study was to determine the addition of surfactant to polymer on viscosity and interfacial tension values.The lowest (CMC) interfacial tension value resulted in concentration 0.3% which is 8.08-E03 dyne/cm. With the addition of 0.3% surfactant to polymer solution (500 ppm, 750 ppm, 1000 ppm, 1250 ppm, 1500 ppm, and 2000 ppm) resulted in a decrease on viscosity value from 4.13 cp, 5.43 cp, 7.26 cp, 9.44 cp, 12.67 cp, and 20.68 cp to 3.52 cp, 5.1 cp, 6.82 cp, 9.23 cp, 11.35 cp, and 19.28 cp, also an increase on interfacial tension value from 8.08 dyne/cm to between 1-E02 dyne/cm.

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Chu, Jieying, Rachel Schell, Faqiang Wu, Michal Krawczyk, Daniel Whang, Segun Jung, Hyunjun Nam, et al. "Abstract 949: A single stranded DNA library preparation workflow used for hybridization capture based WES assay showed superior uniformity." Cancer Research 84, no. 6_Supplement (March 22, 2024): 949. http://dx.doi.org/10.1158/1538-7445.am2024-949.

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Abstract Introduction: In many instances in Precision Oncology Medicine fragmented DNA from formalin-fixed paraffin-embedded (FFPE) samples is the only option. The majority of such degradedsamples need to be sequenced using next generation sequencing (NGS) [1]. Standardizedguidelines highlight that a minimum of 500 × coverage depth is required for tissue analyses [2].However, coverage isn’t the only metric required for a successful NGS analysis. Highly uniformDNA libraries allow clinical labs to generate more hits from their screens, saving both time andmoney across the course of diagnosis therefore ultimately benefits patient care. The commerciallyavailable single stranded DNA library prep kit tested in this study renders all input moleculessingle-stranded before ligation therefore it recovers template molecules containing DNA nicks andlabile lesions thus maximizing library complexity. Method: 10 solid tumor FFPE derived DNA samples went through three different NGS workflows:100ng of DNA input in an amplicon-based assay 325 gene panel (Assay A), 60ng input for a 500gene mechanical sheared-based double strand DNA library preparation with hybridization captureassay (~500 gene panel, Assay B), 50ng and 10ng input for a enzymatic shear-based singlestranded DNA library preparation with hybridization capture assay (WES with 1000+ enhancedgene content, Assay C). Data from assays A and C was processed with in-house bioinformaticpipeline, while Assay B’s data was processed with a commercially available bioinformatic pipelinethat was bundled with the assay. NGS QC metrics were compared across the three datasets. Results: This novel single stranded DNA library preparation with hybridization capture workflowshowed superior QC metrics compared to the other two workflows, especially on coverageuniformity and percent target above 100X, with as low as 10ng input. Conclusion: Employing a novel commercially available DNA library preparation workflow in anNGS assay, NeoGenomics was able to rescue poor quality samples that had previously failed tomeet our internal uniformity metric on other NGS assays and generate robust and reportableresults with as low as 10ng DNA input.[1] Nagahashi et al., J Surg Res. 2017 Dec; 220: 125-132.[2] Cappello et al., J Pers Med. 2022 May; 12(5): 750. Citation Format: Jieying Chu, Rachel Schell, Faqiang Wu, Michal Krawczyk, Daniel Whang, Segun Jung, Hyunjun Nam, Kenneth B. Thomas, Fernando J. Lopez-Diaz, Vincent Funari, Julie A. Mayer, Shashi Kulkarni, Jiannan Guo, Steven P. Lau-Rivera. A single stranded DNA library preparation workflow used for hybridization capture based WES assay showed superior uniformity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 949.

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Moita, Vitor Hugo C., Sung Woo Kim, and Marcos E. Duarte. "PSVII-2 Effects of xylanase and its optimal supplementation level on viscosity of jejunal digesta, nutrient digestibility, intestinal health, and growth performance of nursery pigs." Journal of Animal Science 99, Supplement_3 (October 8, 2021): 407–8. http://dx.doi.org/10.1093/jas/skab235.733.

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Abstract This study aimed to determine supplemental effects of xylanase (endo-β-1,4-xylanase, CJ BIO, Korea) and its optimal supplementation level on viscosity of jejunal digesta, nutrient digestibility, intestinal health, and growth performance of pigs. Sixty weaned pigs (6.9 ± 0.8 kg BW) were randomly allotted to 5 treatments based on a RCBD with initial BW and sex as block and fed in 3 phases (P1/2/3 for 10/14/14 d, respectively). Dietary treatment were the supplementation levels of xylanase providing (0, 220, 440, 880, and 1,760 XU/kg feed). Titanium dioxide (0.4%) was added to P3 diets as an indigestible marker to measure AID. On d 38, all pigs were euthanized to collect ileal and jejunal digesta to measure AID and viscosity, respectively; jejunal mucosa and tissue to measure intestinal health parameters. Data were analyzed using SAS 9.4. Xylanase supplementation from 0 to 350 XU/kg increased (P < 0.05) ADG (596 to 746 g/d) during the last week, whereas there was no effect by xylanase on the overall growth performance. Increasing xylanase supplementation reduced (P < 0.05) digesta viscosity (1.91 to 1.48 mPa.s); increased (P < 0.05) the AID of EE (83.9 to 89.5%), NDF (52.9 to 56.9%) and ADF (35.3 to 39.3%); tended to reduce Cupriavidus (P = 0.073; 1.33 to 0.63%) and Megasphaera (P = 0.063; 1.26 to 0.23%); and tended to increase Succinivibrio (P = 0.076; 1.10 to 2.71%) and Pseudomonas (P = 0.060; 4.89 to 13.29%). Xylanase supplementation from 0 to 520 XU/kg reduced (P < 0.05) jejunal MDA (0.99 to 0.58 µmol/mg protein). In conclusion, xylanase supplementation showed benefits on intestinal health by reducing digesta viscosity, oxidative stress status, and harmful bacteria in the jejunal mucosa and by increasing the AID of nutrients. Xylanase supplementation at a range of 350 to 520 XU/kg feed provided the most benefits.

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Nelson, Michael D., Luis A. Altamirano-Diaz, Stewart R. Petersen, Darren S. DeLorey, Michael K. Stickland, Richard B. Thompson, and Mark J. Haykowsky. "Left ventricular systolic and diastolic function during tilt-table positioning and passive heat stress in humans." American Journal of Physiology-Heart and Circulatory Physiology 301, no. 2 (August 2011): H599—H608. http://dx.doi.org/10.1152/ajpheart.00127.2011.

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The ventricular response to passive heat stress has predominantly been studied in the supine position. It is presently unclear how acute changes in venous return influence ventricular function during heat stress. To address this question, left ventricular (LV) systolic and diastolic function were studied in 17 healthy men (24.3 ± 4.0 yr; mean ± SD), using two-dimensional transthoracic echocardiography with Doppler ultrasound, during tilt-table positioning (supine, 30° head-up tilt, and 30° head-down tilt), under normothermic and passive heat stress (core temperature 0.8 ± 0.1°C above baseline) conditions. The supine heat stress LV volumetric and functional response was consistent with previous reports. Combining head-up tilt with heat stress reduced end-diastolic (25.2 ± 4.1%) and end-systolic (65.4 ± 10.5%) volume from baseline, whereas heart rate (37.7 ± 2.0%), ejection fraction (9.4 ± 2.4%), and LV elastance (37.7 ± 3.6%) increased, and stroke volume (−28.6 ± 9.4%) and early diastolic inflow (−17.5 ± 6.5%) and annular tissue (−35.6 ± 7.0%) velocities were reduced. Combining head-down tilt with heat stress restored end-diastolic volume, whereas LV elastance (16.8 ± 3.2%), ejection fraction (7.2 ± 2.1%), and systolic annular tissue velocities (22.4 ± 5.0%) remained elevated above baseline, and end-systolic volume was reduced (−15.3 ± 3.9%). Stroke volume and the early and late diastolic inflow and annular tissue velocities were unchanged from baseline. This investigation extends previous work by demonstrating increased LV systolic function with heat stress, under varied levels of venous return, and highlights the preload dependency of early diastolic function during passive heat stress.

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van Vollenhoven, R., T. Takeuchi, J. Aelion, N. Chávez, P. Mannucci Walter, A. Singhal, J. Swierkot, et al. "POS0655 LONG-TERM SAFETY AND EFFICACY OF UPADACITINIB IN PATIENTS WITH RHEUMATOID ARTHRITIS: 3-YEAR RESULTS FROM THE SELECT-EARLY STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 568–69. http://dx.doi.org/10.1136/annrheumdis-2021-eular.530.

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Background:Upadacitinib (UPA), an oral Janus kinase inhibitor, demonstrated significant improvements in signs, symptoms, and structural inhibition as monotherapy (mono) vs methotrexate (MTX) in MTX-naïve patients (pts) with rheumatoid arthritis (RA) through 48 weeks (wks).1Objectives:To report the efficacy and safety of UPA vs MTX mono up to 156 wks in pts with RA from the ongoing long-term extension (LTE) of the SELECT-EARLY trial.Methods:During the 48-wk double-blind study period, pts were randomized to UPA 15 or 30 mg once daily (QD) or MTX (titrated to 20 mg/wk by Wk 8). At Wk 26, pts who did not achieve Clinical Disease Activity Index (CDAI) remission (≤2.8) and had <20% improvement from baseline in tender or swollen joint count received blinded rescue therapy (addition of MTX for UPA groups and UPA 15 or 30 mg for MTX group). In the LTE, pts received open-label treatment once the last pt reached Wk 48. Efficacy assessments up to Wk 156 were summarized by randomized group and included American College of Rheumatology (ACR) responses, remission and low disease activity (LDA) measures, and change in modified Total Sharp Score (mTSS; up to 96 wks). Treatment-emergent adverse events (AEs) per 100 pt-years (PY) for pts on continuous mono were summarized through 156 wks. Non-responder imputation was used for binary endpoints for missing data and when pts received rescue therapy or prematurely discontinued the study drug.Results:Of 945 pts randomized and treated, 775 entered the LTE on study drug (including 57 rescued pts; MTX, 33; UPA 15 mg, 17; UPA 30 mg, 7). Overall, 161 (21%) pts discontinued during the LTE. At Wk 156, higher proportions of pts randomized to UPA achieved a 20/50/70% improvement in ACR response (ACR20/50/70), LDA, and remission vs MTX (Figure 1). Change from baseline in mTSS at Wk 96 favored UPA vs MTX (data not shown). Most AEs were numerically more frequent with UPA 30 mg. The overall rate of serious infection was numerically higher with UPA vs MTX (Table 1). Herpes zoster (HZ), neutropenia, non-melanoma skin cancer (NMSC), and creatine phosphokinase (CPK) elevation were more frequent with UPA vs MTX. Two active tuberculosis (TB) events were reported in each UPA arm; 3 adjudicated gastrointestinal (GI) perforation events were observed in the UPA 30 mg arm. Adjudicated major adverse cardiovascular events (MACEs) or venous thromboembolic events (VTEs) were comparable across treatment arms.Conclusion:UPA monotherapy showed sustained clinically meaningful responses including remission vs MTX through Wk 156 but higher rates of several AEs, including HZ, neutropenia, and CPK elevations; no new safety risks were observed compared with previous results.1,2References:[1]van Vollenhoven R, et al. Ann Rheum Dis 2019;78:376–7; 2. Cohen SB, et al. Ann Rheum Dis 2020;annrheumdis-2020-218510.Table 1.Safety overviewE/100 PY (95% CI)MTX mono(n=314; PY=601.9)UPA 15 mg QD mono(n=317; PY=703.4)UPA 30 mg QD mono(n=314; PY=687.6)Any AE240.2(228.0, 252.9)268.0(256.0, 280.4)292.5(279.8, 305.5)Any serious AE10.8 (8.3, 13.8)12.2 (9.8, 15.1)16.3 (13.4, 19.6)Any AE leading to discontinuation of study drug6.5 (4.6, 8.9)7.3 (5.4, 9.5)7.7 (5.8, 10.1)Any deatha0.7 (0.2, 1.7)0.9 (0.3, 1.9)1.0 (0.4, 2.1)Serious infection2.5 (1.4, 4.1)3.3 (2.1, 4.9)4.4 (2.9, 6.2)Opportunistic infection excluding TB and HZ0.2 (0.0, 0.9)0.1 (0.0, 0.8)0.3 (0.0, 1.1)HZ0.8 (0.3, 1.9)4.5 (3.1, 6.4)4.7 (3.2, 6.6)Active TB00.3 (0.0, 1.0)0.3 (0.0, 1.1)NMSC00.4 (0.1, 1.2)1.0 (0.4, 2.1)Malignancy other than NMSC1.0 (0.4, 2.2)0.6 (0.2, 1.5)1.2 (0.5, 2.3)Hepatic disorder14.1 (11.3, 17.5)12.5 (10.0, 15.4)15.0 (12.2, 18.2)GI perforationb000.4 (0.1, 1.3)Neutropenia2.2 (1.2, 3.7)4.5 (3.1, 6.4)5.7 (4.0, 7.8)CPK elevation1.8 (0.9, 3.3)7.7 (5.8, 10.0)15.4 (12.6, 18.6)MACEb0.3 (0.0, 1.2)0.4 (0.1, 1.2)0.6 (0.2, 1.5)VTEb0.3 (0.0, 1.2)0.4 (0.1, 1.2)0.6 (0.2, 1.5)Data were censored at the time of MTX or UPA addition for rescued ptsaIncludes treatment-emergent (≤30 days after the last dose of study drug) and non-treatment-emergent deaths. bAdjudicatedAcknowledgements:AbbVie funded this study; contributed to its design; participated in data collection, analysis, and interpretation of the data; and in the writing, review, and approval of the abstract. No honoraria or payments were made for authorship. Medical writing support was provided by Russell Craddock, PhD, of 2 the Nth (Cheshire, UK), and was funded by AbbVie.Disclosure of Interests:Ronald van Vollenhoven Speakers bureau: AbbVie, AstraZeneca, Biotest, Bristol-Myers Squibb, Galapagos, Gilead, GSK, Janssen, Pfizer, Sanofi, Servier, UCB, and Viela Bio, Consultant of: AbbVie, AstraZeneca, Biogen, Biotest, Bristol-Myers Squibb, Galapagos, Gilead, GSK, Janssen, Pfizer, Sanofi, Servier, UCB, and Viela Bio, Grant/research support from: Bristol-Myers Squibb, GSK, Eli Lilly, Pfizer, Roche, and UCB, Tsutomu Takeuchi Speakers bureau: AbbVie, AYUMI, Bristol-Myers Squibb, Chugai, Daiichi Sankyo, Dainippon Sumitomo, Eisai, Gilead, Mitsubishi Tanabe, Novartis, Pfizer, and Sanofi, Consultant of: Astellas, Chugai, and Eli Lilly, Grant/research support from: AbbVie, Asahi Kasei, Astellas, Chugai, Daiichi Sankyo, Eisai, Mitsubishi Tanabe, Nippon Kayaku, Shionogi, Takeda, and UCB, Jacob Aelion Grant/research support from: AbbVie, Amgen, AstraZeneca, Bristol-Myers Squibb, Celgene, Eli Lilly, Galapagos/Gilead, Genentech, GSK, Horizon, Janssen, Mallinckrodt, Nektar, Nichi-Iko, Novartis, Pfizer, Regeneron, Roche, Sanofi, Selecta, and UCB, Nilmo Chávez Speakers bureau: AbbVie, Janssen, and Pfizer, Consultant of: AbbVie, Janssen, and Pfizer, Grant/research support from: AbbVie, Galapagos, Gilead, Pfizer, and Sanofi, Pablo Mannucci Walter Consultant of: AbbVie, Grant/research support from: AbbVie, Bristol-Myers Squibb, Eli Lilly, Genentech/Roche, GSK, Janssen, and UCB, Atul Singhal Consultant of: AbbVie, Aclaris, Amgen, AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Gilead, Idorsia, Novartis, Oscotec, Pfizer, Regeneron, Roche/Genentech, Sanofi, Selecta, Takeda, UCB, and Viela Bio, Grant/research support from: AbbVie, Aclaris, Amgen, AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Gilead, Idorsia, Novartis, Oscotec, Pfizer, Regeneron, Roche/Genentech, Sanofi, Selecta, Takeda, UCB, and Viela Bio, Jerzy Swierkot Speakers bureau: AbbVie, Accord, BMS, Janssen, MSD, Pfizer, Roche, Sandoz, and UCB, Consultant of: AbbVie, Accord, BMS, Janssen, MSD, Pfizer, Roche, Sandoz, and UCB, Grant/research support from: AbbVie, Accord, BMS, Janssen, MSD, Pfizer, Roche, Sandoz, and UCB, Alan Friedman Shareholder of: May own stock or options in AbbVie, Employee of: AbbVie, Nasser Khan Shareholder of: May own stocks or options in AbbVie, Employee of: AbbVie, Yihan Li Shareholder of: May own stocks or options in AbbVie, Employee of: AbbVie, Xianwei Bu Shareholder of: May own stocks or options in AbbVie, Employee of: AbbVie, Justin Klaff Shareholder of: May own stock or options in AbbVie, Employee of: AbbVie, Vibeke Strand Consultant of: AbbVie, Amgen, Arena, AstraZeneca, Bayer, Bristol-Myers Squibb, Boehringer Ingelheim, Celltrion, Eli Lilly, Genentech/Roche, Gilead, GSK, Ichnos, Inmedix, Janssen, Kiniksa, MSD, Myriad Genetics, Novartis, Pfizer, Regeneron, Sandoz, Sanofi, Setpoint, and UCB

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Bernaudin, Francoise, Emmanuelle Lesprit, Lena Coïc, Cécile Arnaud, Emmanuelle Fleurence, Suzanne Verlhac, and Christophe Delacourt. "Long Term Prospective Follow-Up after Treatment Intensification in Pediatric Sickle Cell Patients: Comparative Effects of Transfusion Program (TP), Hydroxyurea (HU) or Stem Cell Transplant (SCT) on Annual Check-Ups." Blood 106, no. 11 (November 16, 2005): 3196. http://dx.doi.org/10.1182/blood.v106.11.3196.3196.

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Abstract Treatment intensifications in SCD with HU, TP or SCT are applied in order to reduce SCD related complications but their comparative effects have still to be described. We report our experience concerning the annual check-up performed in SCD pediatric patients. Patients and Methods: Among our cohort of 397 SS/Sb0 pediatric SCD patients, 157 of them were intensified with HU (n= 86), TP (n=104) or SCT (n=36) and some of them received successively HU, TP and SCT. HU was proposed to patients > 3 years of age and having experienced more than 3 VOC/ACS/year or < 7g/dl severe anemia. TP defined as > 4 months program was applied in patients with cerebral vasculopathy defined by an history of stroke or abnormal TCD (> 200 cm/sec). TP was also proposed in patients with HU-failure and in patients with frequent VOC, less than 3 years old. SCT was proposed in patients with an indication of treatment intensification and an available HLA identical sibling donor. Annual check-up were performed in our day-care unit. We analysed 1261 check-ups performed and recorded since 1992 in 341 SS/Sb0 patients (sex: 164 F, 177 M). Median age was 8.8 ± 5.1 years. Mean number of annual check-ups per patient was 3.7 ± 2.8 (range 1 to 13): 816 were performed in non intensified patients, 196 in HU, 123 in TP and 126 in transplanted patients. Categories of age were distinguished: < 2 y of age (n=110), 2–5y (n=244), 5–10y (n=415), 10–15y (n=317) and 15–20y (n=175). Results: Respective follow-up were 4.4 y ± 3.3 in HU, 2.6 y ± 2.6 inTP and 5.8 y ± 4.7 in SCT patients. Comparison with non intensified patients showed that weight was significantly higher in SCT patients > 15 y of age (p=0.001), spleen size was significantly higher in (2–5y) young patients treated with HU (p=0.005) or TP (0.001) and in 5–10 y old patients on HU (p=0.046) but no difference was observed after the age of 10 y. O2 saturation was significantly improved after SCT (p<0.001) (98.8 ± 1.0 vs 97.1 ± 2.6) and was unchanged on HU and TP. Cardiac pulsations were significantly (p<0.001) decreased after all type of intensification. Biological data are shown (table1and 2). Conclusion : Treatment intensifications (TP, HU, SC) reduced the decrease of weight observed with aging in SCD patients and significantly reduced anemia using different mechanisms. SCT was the most effective to correct anemia, supress hemolysis and decrease leucocytosis. Intensif. n Follow-up HbF% Eryht Hb MCV Retic mean (SD) No 816 11.4 (9.2) 3.1 (0.9) 8.1 (1.2) 81.4 (8.9) 268.9 (105.2) HU 196 4.4 y. (3.3) 13.9 (7.0) 2.7 (0.6) 8.5 (1.2) 97.7 (13.7) 188 (83.8) TP 126 2.6 y.(2.7) 3.3 (3.1) 3.1 (0.6) 9.1 (1.4) 86.8 (4.8) 258.2 (126.0) SCT 123 5.8 y.(4.7) 4.6 (6.4) 4.3 (0.9) 11.4 (1.6) 81.5 (8.9) 89.4 (63.4) Intensif. n Tot Bili Conj Bili LDH Ferritin Leucocytes Platelets No 816 49.8 (34.4) 5.7 (3.4) 1016 (312) 192 (322) 13.2 (9.9) 385 (124) HU 196 47.5 (34.4) 5.0 (2.2) 943 (264) 399 (582) 9.7 (3.8) 352 (133) TP 126 58.8 (39.6) 5.6 (2.2) 973 (377) 2238 (6310) 13.1 (4.7) 365 (128) SCT 123 15.6 (13.9) 2.8 (4.2) 493 (200) 1099 (1386) 6.8 (3.3) 295 (109)

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Olsson, Daniel S., Eva Andersson, Ing-Liss Bryngelsson, Anna G. Nilsson, and Gudmundur Johannsson. "Excess Mortality and Morbidity in Patients with Craniopharyngioma, Especially in Patients with Childhood Onset: A Population-Based Study in Sweden." Journal of Clinical Endocrinology & Metabolism 100, no. 2 (February 1, 2015): 467–74. http://dx.doi.org/10.1210/jc.2014-3525.

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Abstract Context: Craniopharyngiomas (CPs) in adults have been associated with excess mortality. Objective: The aim of the study was to investigate mortality and morbidity in patients with childhood-onset and adult-onset CP. Methods: Patients with CP were identified and followed in Swedish national health registries, 1987 through 2011. The inclusion criteria for the CP diagnosis were internally validated against patient records in 28% of the study population. Settings: This was a nationwide population-based study. Patients: A total of 307 patients (151 men and 156 women) were identified and included (mean follow-up, 9 years; range, 0–25 years). The inclusion criteria had a positive predictive value of 97% and a sensitivity of 92%. Intervention: There were no interventions. Main Outcome Measures: Standardized mortality ratios (SMRs) and standardized incidence ratios (SIRs) with 95% confidence intervals were calculated using the Swedish population as the reference. Results: During the study, 54 patients died compared with the expected number of 14.1, resulting in an SMR of 3.2 (2.2–4.7) for men and 4.9 (3.2–7.2) for women. Patients with childhood-onset (n = 106) and adult-onset (n = 201) CP had SMRs of 17 (6.3–37) and 3.5 (2.6–4.6), respectively. Patients with hypopituitarism (n = 250), diabetes insipidus (n = 110), and neither of these (n = 54) had SMRs of 4.3 (3.1–5.8), 6.1 (3.5–9.7), and 2.7 (1.4–4.6), respectively. The SMR due to cerebrovascular diseases was 5.1 (1.7–12). SIRs were 5.6 (3.8–8.0) for type 2 diabetes mellitus, 7.1 (5.0–9.9) for cerebral infarction, 0.7 (0.2–1.7) for myocardial infarction, 2.1 (1.4–3.0) for fracture, and 5.9 (3.4–9.4) for severe infection. The SIR for all malignant tumors was 1.3 (0.8–2.1). Conclusions: This first nationwide population-based study of patients with CP demonstrated excess mortality that was especially marked in patients with childhood-onset disease and among women. Death due to cerebrovascular diseases was increased 5-fold. Hypopituitarism and diabetes insipidus were negative prognostic factors for mortality and morbidity. Patients with CP had increased disease burden related to type 2 diabetes mellitus, cerebral infarction, fracture, and severe infection.

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Omari, Ali M., Bertrand W. Parcells, Harlan B. Levine, Ari Seidenstein, Javad Parvizi, and Gregg R. Klein. "2021 John N. Insall Award: Aspirin is effective in preventing propagation of infrapopliteal deep venous thrombosis following total knee arthroplasty." Bone & Joint Journal 103-B, no. 6 Supple A (June 1, 2021): 18–22. http://dx.doi.org/10.1302/0301-620x.103b6.bjj-2020-2436.r1.

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Aims The optimal management of an infrapopliteal deep venous thrombosis (IDVT) following total knee arthroplasty (TKA) remains unknown. The risk of DVT propagation and symptom progression must be balanced against potential haemorrhagic complications associated with administration of anticoagulation therapy. The current study reports on a cohort of patients diagnosed with IDVT following TKA who were treated with aspirin, followed closely for development of symptoms, and scanned with ultrasound to determine resolution of IDVT. Methods Among a cohort of 5,078 patients undergoing TKA, 532 patients (695 TKAs, 12.6%) developed an IDVT between 1 January 2014 to 31 December 2019 at a single institution, as diagnosed using Doppler ultrasound at the first postoperative visit. Of the entire cohort of 532 patients with IDVT, 91.4% (486/532) were treated with aspirin (325 mg twice daily) and followed closely. Repeat lower limb ultrasound was performed four weeks later to evaluate the status of IDVT. Results Follow-up Doppler ultrasound was performed on 459/486 (94.4%) patients and demonstrated resolution of IDVT in 445/459 cases (96.9%). Doppler diagnosed propagation of IDVT to the popliteal vein had occurred in 10/459 (2.2%) cases. One patient with an IDVT developed a pulmonary embolus six weeks postoperatively. Conclusion The results of this study demonstrate a low rate of IDVT propagation in patients managed with aspirin. Additionally, no significant bleeding episodes, wound-related complications, or other adverse events were noted from aspirin therapy. Cite this article: Bone Joint J 2021;103-B(6 Supple A):18–22.

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Tanaka, Kenichi, Kazuya Hosokawa, Tomoko Ohnishi, Hisayo Sameshima, Takehiko Koide, and Ikuro Maruyama. "Combined Dabigatran and Antiplatelet Agents Assessed by the Novel Microchip-Based Flow Chamber System." Blood 120, no. 21 (November 16, 2012): 1167. http://dx.doi.org/10.1182/blood.v120.21.1167.1167.

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Abstract Abstract 1167 Evaluation of the overall antithrombotic activity of dabigatran in combination with antiplatelet agents is difficult because plasma-based clotting for dabigatran, and platelet aggregometry in anticoagulated blood are two separate tests which do not reflect physiological interactions between soluble factors and platelets. The use of a flow chamber could be more suitable in evaluating a flow-dependent platelet activation and coagulation responses. The aim of the current study was to comparatively evaluate antithrombotic effects of dabigatran in combination with dual antiplatelet therapy (aspirin plus P2Y12 blockade) using the microchip-based flow chamber (T-TAS, Fujimori Kogyo, Japan)(1), and thrombin generation (TG) assay (Thrombinoscope, Maastricht, the Netherlands)(2). After the local ethics committee approval, blood samples were obtained from consented 5 healthy volunteers in the tubes containing 3.2% sodium citrate. Whole blood samples were mixed with dabigatran (250, 500, 1000 nM), aspirin (100 nM) plus ARC-66096 (P2Y12 inhibitor, 1000 nM) at 25¡C for 10 min. Corn trypsin inhibitor (50 μg/ml) was used to prevent contact activation. The whole blood sample was perfused in the capillary pre-coated with collagen and thromboplastin at the shear rate of 240 or 600 s−1. The process of thrombus formation was monitored by flow pressure increases inside the capillary; (i) lag time before it reaches 10 kPa (T10), (ii) occlusion time (OT) is the lag time before it reaches 80 kPa as thrombus completely occludes the capillary, and (iii) AUC30 is an area under the flow pressure curve (under 80 kPa) after 30 min of perfusion. For TG assay, platelet-rich plasma (platelet count 150 × 103/μl) was prepared from citrated whole blood. TG was triggered by adding 20 μl of CaCl2-fluorogenic substrate buffer to 80 μl of the sample mixed with tissue factor (1 pM) in each well. The lag time (min), and peak thrombin concentration (nM) were evaluated. In the flow chamber, dabigatran inhibited white thrombus formation in a concentration dependent manner at shear rates of 240 and 600 s−1(Fig. 1). At 500 nM of dabigatran, OT was prolonged by ∼2-fold from the (non-treated) control at both shear rates. The combination of aspirin and AR-C66096 only weakly suppressed thrombus formation, but it enhanced the antithrombotic efficacy of dabigatran at both shear rates (Fig. 1). In TG measurements using platelet-rich plasma, dabigatran at 500 nM prolonged the by 3.17-fold, and reduced the peak by 57.6% compared to the untreated control (Table 1). Aspirin and AR-C66096 weakly prolonged the lag time without affecting the peak height. There were relatively small changes in these parameters when antiplatelet agents were combined with dabigatran (Table 1). Our results suggest that combined antithrombotic effects of dabigatran, aspirin, and P2Y12inhibition can be demonstrated in the whole blood using the flow chamber system compared without additional plasma preparation required for TG assay. The re-calcified whole blood was perfused at the shear rate of 240 s−1 or 600 s−1. Asp/AR-C=aspirin and AR-C66096 Table 1. Lag time (min) Peak (nM) Native Asp/AR-C Native Asp/AR-C Control 6.8 ± 0.8 9.4 ± 3.2 92.1 ± 23.7 91.2 ± 29.5 Dabi 250 nM 18.6 ± 5.4 21.1 ± 4.5 69.3 ± 20.6 52.2 ± 13.6 Dabi 500 nM 21.6 ± 5.3 26.2 ± 10.2 53.0 ± 5.8 47.8 ± 9.1 Dabi 1000 nM 30.2 ± 5.6 35.1 ± 6.3 23.0 ± 6.9 22.0 ± 8.4 Dabi=dabigatran, Native=no antiplatelet agents, Asp/AR-C=aspirin and AR-C66096 Disclosures: Hosokawa: Fujimori Kogyo: Employment. Ohnishi:Fujimori Kogyo: Employment. Sameshima:Fujimori Kogyo: Employment.

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Beviá-Romero, Álvaro, Francisco Quereda-Flores, Javier Díaz-Carnicero, Francisco Gómez-Palomo, María Ramos-Cebrián, Joaquín Espinosa-Vañó, Dario J. Castillo-Antón, Enrique Broseta-Rico, David Vivas-Consuelo, and Alberto Budía-Alba. "Kidney Transplant: Survival Analysis and Prognostic Factors after 10 Years of Follow-Up." Mathematics 11, no. 7 (March 28, 2023): 1640. http://dx.doi.org/10.3390/math11071640.

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The aim of this work is to analyse recipient and graft survival after kidney transplant in a three-year cohort and to identify predictive factors with up to 10 years of follow-up. Methods: retrospective consecutive cohort study of 250 kidney transplant recipients operated between 2010 and 2012. Multiorganic transplants and both dead-donor and living-donor transplants were included. Data were collected from electronic health records. A survival analysis was conducted using the Kaplan-Meier method and a Cox proportional-hazards multivariate model. Results: mean follow-up was 8.1 ± 3.2 years. Graft survival at 2, 5 and 10 years was 89.0%, 85.1% and 78.4% respectively. The multivariate model identified the following risk factors for graft loss: diabetic nephropathy (HR 3.2 CI95% [1.1–9.4]), delayed graft function (3.8 [2.0–7.4]), chronic kidney rejection (3.7 [1.2–11.4]), and early surgical complications (2.6 [1.4–5.1]). Conversely, combined transplant was found to be a protective factor for graft loss (0.1 [0.0–0.5]). Recipient patient survival was 94.3%, 90.0% and 76.6% at 2, 5 and 10 years respectively. The model identified the following mortality risk factors: older recipient age (1.1 [1.1–1.2]), combined transplant (7.6 [1.7–34.5]) and opportunistic infections (2.6 [1.3–5.0]). Conclusions: 10-year recipient and graft survival were 76.6% and 78.4% respectively. Main mortality risk factors were older recipient age, opportunistic infections and multiorganic transplant. Main graft loss risk factors were diabetic nephropathy, delayed graft function, chronic kidney rejection and early surgical complications.

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Gryaznova, N., Olga Konovalova, and Nataliya Pleshkova. "SERVQUAL Method in Retail Service Assessment." Food Processing: Techniques and Technology 50, no. 2 (June 27, 2020): 343–50. http://dx.doi.org/10.21603/2074-9414-2020-2-343-350.

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Introduction. Service quality and variety is currently the key success factor in retail trade. Retail service assessment can improve customer experience. The SERVQUAL method makes it possible to evaluate the service quality and solve the detected problems in customer service, thus securing the brand loyalty. Study objects and methods. The present research was based on a customer service survey conducted among 500 customers of the Lenta hypermarket in Kemerovo (Russia) in 2018. The results of the questionnaire underwent a SERVQUAL analysis. The obtained data on the customers’ needs and the degree of their satisfaction with the hypermarket customer service made it possible to develop recommendations for the retail chain. Results and discussion. The respondents answered three groups of questions: expectations, experience, and importance. The assortment of goods proved to be the most important factor, and there were no complaints in this respect regarding the Lenta retail chain. The attended time was rated second. Its assessment demonstrated a gap between the expectations and the experience (Q = –1.3). Retail space service also proved important; however, this aspect of service quality demonstrated the greatest gap between expectations and experience. Conclusion. The three-part SERVQUAL questionnaire helped to reveal the problems in the organization of the shopping service. The subsequent improvement will be important for consumers and the retail chain.

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Demetrio, D., A. Magalhaes, M. Oliveira, R. Santos, and R. Chebel. "11 Invivo-derived embryo pregnancy rates at Maddox Dairy from 2008 to 2018." Reproduction, Fertility and Development 32, no. 2 (2020): 130. http://dx.doi.org/10.1071/rdv32n2ab11.

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Maddox Dairy, located in Riverdale, CA, USA, is a Holstein herd that milks 3500 cows with a 305-day mature-equivalent milk production of 12 800 kg, and they have been producing high genetic animals by embryo transfer (ET) since the early 1980s. Invivo-derived embryos from Holstein donors were transferred fresh (grade 1 or 2) or frozen (grade 1), at morula (4), early blastocyst (5), or blastocyst (6) stage, to virgin heifers (VH, natural oestrus, 13-15 months old) or lactating cows (LC, Presynch-Ovsynch, 86 days in milk, first or second lactation) 6 to 9 days after oestrus. Pregnancy diagnosis was done by transrectal ultrasonography at 32-46 days in VH and by the IDEXX PAG test at 30 days in LC. June, July, August, September, and October were called critical months (first service AI conception rate drops below 44%) and compared with the other months. The data from 32 503 ETs between January 2008 and December 2018 are summarised on Table 1. Pregnancy rates (PR) are lower for LC recipients than for VH. Embryo transfers performed 7 or 8 days after oestrus had higher PR in both types of recipients and embryos, but Day 6 and 9 oestrus are also used with fair results. The season does not seem to affect PR. There is not enough difference in the combination of stage and days from oestrus for invivo-derived embryos. These numbers do not belong to a planned experiment. Several management changes during the years were made, which make it very difficult to apply statistical methods to analyse the data correctly. They are used as a tool to make decisions in an attempt to improve future results. Table 1.Pregnancy rate (PR) of virgin heifers (top) and lactating cows (bottom)-fresh (SH) and frozen (OZ) invivo-derived embryo transfer1 Heat-months SH-ST4 SH-ST5 SH-ST6 SH-All OZ-ST4 OZ-ST5 OZ-ST6 OZ-All PR% n PR% n PR% n PR% n PR% n PR% n PR% n PR% n Heifers 6 d-CM 62 934 66 243 68 69 63 1246 56 473 58 219 62 42 57 734 6 d-OM 62 1623 67 489 69 211 64 2323 56 600 55 296 48 137 55 1033 6 d-T 62 2557 67 732 69 280 63 3569 56 1073 57 515 51 179 56 1767 7 d-CM 64 1506 68 495 67 221 65 2222 60 822 62 340 63 156 61 1318 7 d-OM 66 2723 68 1021 69 510 67 4254 57 1120 59 581 57 231 58 1932 7 d-T 66 4229 68 1516 69 731 67 6476 58 1942 60 921 60 387 59 3250 8 d-CM 65 1348 64 518 67 322 65 2188 59 595 64 258 63 108 61 961 8 d-OM 66 2166 68 886 70 510 67 3562 61 770 60 364 51 130 60 1264 8 d-T 66 3514 67 1404 69 832 66 5750 60 1365 62 622 56 238 60 2225 9 d-CM 60 109 56 43 70 20 60 172 60 5 33 6 50 4 47 15 9 d-OM 58 129 63 57 60 40 60 226 63 16 50 18 75 4 58 38 9 d-T 59 238 60 100 63 60 60 398 62 21 46 24 63 8 55 53 All-CM 64 3897 66 1299 67 632 65 5828 58 1895 61 823 63 310 60 3028 All-OM 65 6641 67 2453 69 1271 66 10 365 58 2506 58 1259 53 502 58 4267 All-T 65 10 538 67 3752 69 1903 66 16 193 58 4401 60 2082 57 812 59 7295 Lactating cows 6 d-CM 54 265 48 86 50 12 53 363 38 141 31 77 50 10 36 228 6 d-OM 49 463 52 203 45 56 50 723 46 101 48 54 59 27 48 182 6 d-T 51 728 51 289 46 68 51 1086 41 242 38 131 57 37 42 410 7 d-CM 54 755 59 274 56 103 55 1137 43 928 48 450 43 192 45 1570 7 d-OM 55 914 66 367 54 109 58 1393 46 1052 45 564 47 353 46 1969 7 d-T 55 1669 63 641 55 212 57 2530 45 1980 46 1014 46 545 45 3539 8 d-CM 63 252 68 82 76 33 65 368 48 219 56 80 42 33 50 332 8 d-OM 61 257 64 161 53 47 61 466 50 191 53 77 56 16 51 284 8 d-T 62 509 65 243 63 80 63 834 49 410 55 157 47 49 50 616 All-CM 56 1272 58 442 60 148 57 1868 44 1288 47 607 43 235 45 2130 All-OM 55 1634 62 731 51 212 56 2582 47 1344 46 695 48 396 47 2435 All-T 55 2906 60 1173 55 360 57 4450 45 2632 47 1302 46 631 46 4565 1ST=stage; CM=critical months (June, July, August, September, and October); OM=other months.

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Mihiretie, Hylemariam, Bineyam Taye, and Aster Tsegaye. "Magnitude of Anemia and Associated Factors among Pediatric HIV/AIDS Patients Attending Zewditu Memorial Hospital ART Clinic, Addis Ababa, Ethiopia." Anemia 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/479329.

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Background. Anemia is one of the most commonly observed hematological abnormalities and an independent prognostic marker of HIV disease. The aim of this study was to determine the magnitude of anemia and associated factors among pediatric HIV/AIDS patients attending Zewditu Memorial Hospital (ZMH) ART Clinic in Addis Ababa, Ethiopia.Methods. A cross-sectional study was conducted among pediatric HIV/AIDS patients of Zewditu Memorial Hospital (ZMH) between August 05, 2013, and November 25, 2013. A total of 180 children were selected consecutively. Stool specimen was collected and processed. A structured questionnaire was used to collect data on sociodemographic characteristics and associated risk factors. Data were entered into EpiData 3.1.1. and were analyzed using SPSS version 16 software. Logistic regressions were applied to assess any association between explanatory factors and outcome variables.Results. The total prevalence of anemia was 22.2% where 21 (52.5%), 17 (42.5%), and 2 (5.0%) patients had mild, moderate, and severe anemia. There was a significant increase in severity and prevalence of anemia in those with CD4+ T cell counts below 350 cells/μL (P<0.05). Having intestinal parasitic infections (AOR = 2.7, 95% CI, 1.1–7.2), having lower CD4+ T cell count (AOR = 3.8, 95% CI, 1.6–9.4), and being HAART naïve (AOR = 2.3, 95% CI, 1.6–9.4) were identified as significant predictors of anemia.Conclusion. Anemia was more prevalent and severe in patients with low CD4+ T cell counts, patients infected with intestinal parasites/helminthes, and HAART naïve patients. Therefore, public health measures and regular follow-up are necessary to prevent anemia.

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Weng, Wenhan, Xiao Li, Shushi Meng, Xianping Liu, Peng Peng, Zhenfan Wang, Jianfeng Li, and Jun Wang. "Video-assisted thoracoscopic thymectomy is feasible for large thymomas: a propensity-matched comparison." Interactive CardioVascular and Thoracic Surgery 30, no. 4 (January 28, 2020): 565–72. http://dx.doi.org/10.1093/icvts/ivz320.

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Abstract OBJECTIVES Video-assisted thoracoscopic thymectomy is becoming the preferable approach for early-stage thymoma. However, large thymomas are still recognized as a relative contraindication due to the possible risk of incomplete resection or capsular disruption. Thus, the aim of this study is to evaluate the feasibility of video-assisted thoracoscopic thymectomy for large thymomas. METHODS Patients diagnosed with Masaoka stage I–IV thymoma between April 2001 and December 2018 were retrospectively reviewed. All patients were divided into 2 groups: thymoma <5.0 cm (group A) and thymoma ≥5.0 cm (group B). Propensity score matching analysis was performed to compare postoperative results. Recurrence-free survival and overall survival were compared for oncological evaluation. RESULTS A total of 346 patients were included in this study. In the propensity score matching analysis, 126 patients were included both in group A and group B. There was no significant difference between these 2 groups in terms of the R0 resection rate (95.2% vs 94.4%, P = 1.000), conversion rate (1.6% vs 3.2%, P = 0.684), operation time (119.4 ± 48.4 vs 139.1 ± 46.6 min, P = 0.955), blood loss (93.2 ± 231.7 vs 100.5 ± 149.3 ml, P = 0.649), duration of chest drainage (2.7 ± 1.6 vs 2.8 ± 2.0 days, P = 0.184), length of hospitalization (5.0 ± 3.9 vs 5.2 ± 2.9 days, P = 0.628) or postoperative complications (5.9% vs 8.5%, P = 0.068). There was no significant difference between these 2 groups in terms of the overall survival (P = 0.271) and recurrence-free survival (P = 0.288). CONCLUSIONS Video-assisted thoracoscopic thymectomy is a safe and effective approach for large thymomas (≥5 cm) with comparable surgical and oncological results.

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Rozalén, Juana, María de las Mercedes García-Martínez, María Engracia Carrión, Manuel Carmona, Horacio López-Córcoles, Katrina Cornish, and Amaya Zalacain. "Adapting the Accelerated Solvent Extraction Method for Resin and Rubber Determination in Guayule Using the BÜCHI Speed Extractor." Molecules 26, no. 1 (January 1, 2021): 183. http://dx.doi.org/10.3390/molecules26010183.

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Guayule (Parthenium argentatum Gray) is a promising alternative source to Hevea brasiliensis for the production of natural rubber, which can reach levels of 8–9% under industrialized farming conditions. The most common method for determining rubber concentration is by accelerated solvent extraction (ASE), a technique developed by the Dionex Corporation and almost exclusively performed with the Dionex ASE-200 or 350 systems. Herein, it is sought to apply and adapt the most common methods used in the literature for the Dionex system to another extraction platform, the BÜCHI Speed Extractor E-914. Results showed that using a sand sandwich method to confine the sample in the center and exploiting a larger cell volume (80 mL) for extraction prevents the occurrence of overpressure and problems with clogging. Under optimized conditions, the coefficient of variation was <15% for both resin quantification for samples containing 5.0–15.8% of resin and for rubber quantification for samples with 1.7–10.3% rubber content. The extraction time for resin (2 cycles of 5 min each) was smaller than for rubber (2 cycles of 20 min each). It would be interesting to carry out interlaboratory comparisons to standardize the method at an international level.

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Gibson, Dustin G., Adaeze C. Wosu, George William Pariyo, Saifuddin Ahmed, Joseph Ali, Alain B. Labrique, Iqbal Ansary Khan, Elizeus Rutebemberwa, Meerjady Sabrina Flora, and Adnan A. Hyder. "Effect of airtime incentives on response and cooperation rates in non-communicable disease interactive voice response surveys: randomised controlled trials in Bangladesh and Uganda." BMJ Global Health 4, no. 5 (September 2019): e001604. http://dx.doi.org/10.1136/bmjgh-2019-001604.

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BackgroundThe global proliferation of mobile phones offers opportunity for improved non-communicable disease (NCD) data collection by interviewing participants using interactive voice response (IVR) surveys. We assessed whether airtime incentives can improve cooperation and response rates for an NCD IVR survey in Bangladesh and Uganda.MethodsParticipants were randomised to three arms: a) no incentive, b) 1X incentive or c) 2X incentive, where X was set to airtime of 50 Bangladesh Taka (US$0.60) and 5000 Ugandan Shillings (UGX; US$1.35). Adults aged 18 years and older who had a working mobile phone were sampled using random digit dialling. The primary outcomes, cooperation and response rates as defined by the American Association of Public Opinion Research, were analysed using log-binomial regression model.ResultsBetween 14 June and 14 July 2017, 440 262 phone calls were made in Bangladesh. The cooperation and response rates were, respectively, 28.8% (353/1227) and 19.2% (580/3016) in control, 39.2% (370/945) and 23.9% (507/2120) in 50 Taka and 40.0% (362/906) and 24.8% (532/2148) in 100 Taka incentive groups. Cooperation and response rates, respectively, were significantly higher in both the 50 Taka (risk ratio (RR) 1.36, 95% CI 1.21 to 1.53) and (RR 1.24, 95% CI 1.12 to 1.38), and 100 Taka groups (RR 1.39, 95% CI 1.23 to 1.56) and (RR 1.29, 95% CI 1.16 to 1.43), as compared with the controls. In Uganda, 174 157 phone calls were made from 26 March to 22 April 2017. The cooperation and response rates were, respectively, 44.7% (377/844) and 35.2% (552/1570) in control, 57.6% (404/701) and 39.3% (508/1293) in 5000 UGX and 58.8% (421/716) and 40.3% (535/1328) in 10 000 UGX groups. Cooperation and response rates were significantly higher, respectively in the 5000 UGX (RR 1.29, 95% CI 1.17 to 1.42) and (RR 1.12, 95% CI 1.02 to 1.23), and 10 000 UGX groups (RR 1.32, 95% CI 1.19 to 1.45) and (RR 1.15, 95% CI 1.04 to 1.26), as compared with the control group.ConclusionIn two diverse settings, the provision of an airtime incentive significantly improved both the cooperation and response rates of an IVR survey, with no significant difference between the two incentive amounts.Trial registration numberNCT03768323.

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Odion, Dennis C. "Fire in California's Ecosystems Neil G. Sugihara, Jan W. van Wagtendonk, Kevin E. Shaffer, Joann Fites Kaufman, Andrea E. Thode . University of California Press. Berkeley, CA. 612 pp $75.00. ISBN: ISBN-13 948-0-520-24605-8." Madroño 54, no. 4 (October 18, 2007): 354–65. http://dx.doi.org/10.3120/0024-9637(2007)54[354:fice]2.0.co;2.

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Desai, Payal C., Luca Delatore, Deborah Hanes, Amy Rettig, Miranda Gill, Jason Walsh, Emily Graham, and Eric Adkins. "A Successful Model for Adult Emergency Medicine Protocol Implementation for Sickle Cell Disease." Blood 126, no. 23 (December 3, 2015): 2078. http://dx.doi.org/10.1182/blood.v126.23.2078.2078.

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Abstract Introduction: Sickle Cell Disease (SCD) affects approximately 1 in 350 African American newborn infants each year in the United States and 70,000-100,000 people in the United States. Vaso-occlusive pain crisis is the most common complication that results in patients seeking emergency care for sickle cell disease. In the US in 2006, an estimated 232,381 emergency department (ED) visits were related to sickle cell disease, which resulted in approximately $356 million of ED health care costs and $2.6 billion of combined ED and inpatient costs. Initial pediatric data suggests that time to opiate initiation effectively decreased the total ED length of stay, and total intravenous opiates. While adult ED protocols have been implemented, results on time to first opiate as well as health care utilization has been variable. Methods: A multidisciplinary quality improvement group was formed to improve emergency room department care delivery for patients with sickle cell disease. The existing NIH 2014 sickle cell guideline and Tanabe protocol was modified to include individualized pain plans (Figure 1). The primary goal was defined as average time to first opiate of < 60 minutes. The secondary goal was to improve long term health care utilization as measures by length of ED stay and readmission rates for patients with sickle cell disease. The data was compared to a year prior to protocol implementation given the seasonal variations observed in patient admissions and encounter volumes. For reporting, those patients that require a toxicology screen prior to opiate administration were excluded from the data analysis. Results: There were a total of 352 encounters from 102 unique patients that occurred time of protocol initiation (January 2015-June 2015). The average time to first opiate in January 2014 was 170 min and June 2014 was 166min. After protocol implementation, the average time to first opiate in January 2015 was 123 min and June 2015 62 min (Figure 2). The readmission rate compared to May and June 2014 was decreased by 43% and 20% in May and June 2015, respectively. The average length of ED stay decreased from 9.4 hrs in June 2014 to 5.0 hrs in June 2015 (Figure 3). Conclusion: With a collaborative multi-disciplinary approach, successful ED protocol implementation is feasible. The collaboration can lead to better patient care with improvement in time to analgesia. The model may also contribute to reduction in health care utilization. Figure 1. ED Pain Protocol Algorithm Figure 1. ED Pain Protocol Algorithm Figure 2. Time to First Opiate (mins) Figure 2. Time to First Opiate (mins) Figure 3. Length of Stay in the Emergency Department (Hrs) Figure 3. Length of Stay in the Emergency Department (Hrs) Disclosures Desai: Pfizer: Consultancy.

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Hsia, Renee Y., Stefany Zagorov, Nandita Sarkar, Michael T. Savides, Madeline Feldmeier, and Newton Addo. "Patterns in Patient Encounters and Emergency Department Capacity in California, 2011-2021." JAMA Network Open 6, no. 6 (June 22, 2023): e2319438. http://dx.doi.org/10.1001/jamanetworkopen.2023.19438.

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ImportanceThe health care system has undergone major changes in the past decade, and emergency department (ED) crowding has worsened over time; however, the most recent patterns in ED capacity and use in California have yet to be studied.ObjectiveTo analyze patterns in ED capacity and utilization in California hospitals from 2011 to 2021.Design, Setting, and ParticipantsThis retrospective cohort study used data from the California Department of Health Care Access and Information and the US Census Bureau to analyze ED facility characteristics from more than 400 general acute care hospitals with more than 320 EDs in California as well as patients who presented to those EDs between January 1, 2011, and December 31, 2021.Main Outcomes and MeasuresLinear patterns (measured by percentage change) in total annual ED capacity (volume of hospital beds, EDs, ED treatment stations, and trauma centers) and ED use (ED visits by disposition and acuity) were assessed as primary outcomes. Patterns in ambulance diversion hours and the number of patients who left the ED without being seen were also examined as secondary outcomes. Visit acuity was categorized into 5 levels by increasing severity (minor, low to moderate, moderate, severe without threat, and severe with threat) based on California Department of Health Care Access and Information descriptions corresponding to Current Procedural Terminology codes.ResultsIn the prepandemic period (2011-2019), the total population of California increased from 37 638 369 to 39 512 223 (5.0%; 95% CI, 4.1%-5.8%), then decreased to 39 237 836 in 2021 (0.7%; 95% CI, −3.9% to 2.5%). Over the entire study period (2011-2021), the total California population increased by 4.2% (95% CI, 3.3%-5.2%). From 2011 to 2019, the annual number of ED visits increased from 12 054 885 to 14 876 653 (23.4%; 95% CI, 20.0%-26.8%) before decreasing to 12 944 692 in 2021 (−13.0%; 95% CI, −33.1% to 7.1%); from 2011 to 2021, total ED visits increased by 7.4% (95% CI, 5.6%-9.1%). From 2011 to 2021, the total number of EDs decreased from 339 to 326 (−3.8%; 95% CI, −4.4% to −3.2%) and the total number of hospital beds decreased from 75 940 to 74 052 (−2.5%; 95% CI, −3.3% to −1.6%), while the number of ED treatment stations in these fewer EDs increased from 7159 to 8667 (21.1%; 95% CI, 19.7%-22.4%). The number of visits rated as severe with threat also increased, from 2 011 637 in 2011 to 3 375 539 in 2021 (67.8%; 95% CI, 59.7%-75.9%), while visits rated as minor decreased from 913 712 to 336 071 (−63.2%; 95% CI, −75.2% to −51.2%) over the same period.Conclusions and RelevanceIn this cohort study, multiple measures of ED capacity did not proportionally increase with the increasing demand for services; however, the COVID-19 pandemic appears to have substantially affected some of these patterns. These findings may be helpful to policy makers and health care stakeholders when planning resource allocation of limited health care resources.

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Hodges, Gethin, Jannik Pallisgaard, Anne-Marie Schjerning Olsen, Patricia McGettigan, Mikkel Andersen, Maria Krogager, Kristian Kragholm, et al. "Association between biomarkers and COVID-19 severity and mortality: a nationwide Danish cohort study." BMJ Open 10, no. 12 (December 2020): e041295. http://dx.doi.org/10.1136/bmjopen-2020-041295.

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ObjectiveTo evaluate the association between common biomarkers, death and intensive care unit (ICU) admission in patients with COVID-19.DesignRetrospective cohort study. From electronic national registry data, we used Cox analysis and bootstrapping to evaluate associations between baseline levels of biomarkers and standardised absolute risks of death/ICU admission, adjusted for age and gender.SettingAll hospitals in Denmark.Participants1310 patients aged ≥18 years admitted to hospital with COVID-19 from 27th of February to 1st of May 2020, with available biochemistry data.Main outcome measuresA composite of death/ICU admission occurring within 30 days.ResultsOf the 1310 patients admitted to hospital (54.6% men; median age 73.6 years), 352 (26.9%) experienced the composite endpoint and 263 (20.1%) died. For the composite endpoint, the absolute risks for moderately and severely elevated C reactive protein (CRP) were significantly higher, 21.5% and 39.2%, respectively, compared with 5.0% for those with normal CRP. Moderately and severely elevated leucocytes were significantly higher, 34.5% and 46.6% risk, respectively, compared with 23.2% for those with normal leucocytes. Moderately and severely decreased estimated glomerular filtration rates (eGFR) were significantly higher, 41.5% and 45.9% risk, respectively, compared with 30.4% for those with normal/mildly decreased eGFR. Normal and elevated ureas were significantly higher, 22.3% and 40.6% risk, respectively, compared with 7.3% for those with low urea. Elevated D-dimer was significantly higher, 31.8% risk, compared with 17.5% for those with normal D-dimer. Moderately and severely elevated troponins were significantly higher, 27.7% and 57.3% risk, respectively, compared with 9.4% for those with normal troponin. Elevated procalcitonin was significantly higher, 52.1% risk, compared with 28.0% for those with normal procalcitonin.ConclusionIn this nationwide study of patients admitted with COVID-19, elevated levels of CRP, leucocytes, procalcitonin, urea, troponins and D-dimer, and low levels of eGFR were associated with higher standardised absolute risk of death/ICU admission within 30 days.

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Derenzo, Neide, Daiany Joice Cuba de Miranda, Samuel Luciano Pereira da Silva, Igor Fernando Neves, Renata Rodrigues Mendonça, Drielly Lima Valle Folha Salvador, Heloá Costa Borim Christinelli, and Kely Paviani Stevanato. "Perfil do atendimento de urgência e emergência em uma base do noroeste do Paraná." Research, Society and Development 10, no. 5 (May 1, 2021): e14010514859. http://dx.doi.org/10.33448/rsd-v10i5.14859.

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Objetivo: Analisar o perfil epidemiológico das ocorrências de uma base descentralizada do SAMU 192 em um município do Noroeste do Paraná. Metodologia: O presente estudo é retrospectivo, analítico, de abordagem quantitativa. Para tal, foram utilizadas as fichas de atendimentos realizados entre janeiro a março de 2019. Foram coletados dados referentes às características sociodemográficas das vítimas e os tipos de atendimentos de urgência e emergência realizados pelos profissionais. O Presente estudo foi submetido e aprovado pelo Comitê de Ética em Pesquisa da Universidade Estadual do Paraná, respeitando os preceitos éticos da Resolução 466/2012 e 510/2016 do Conselho Nacional de Saúde, sob protocolo de aprovação nº 3.313.124 Resultados: Observou que das 941 fichas de atendimentos analisadas 653 (69,4%) por causas clínicas, 196 (20,8%) por traumas, 62 (6,6%) ocorrências psiquiátricas e 30 (3,2%) causas gineco-obstétricas. Evidenciou diferença estatística significativa na comparação entre os sexos, em relação à natureza da ocorrência e o tipo de ambulância disponibilizada para o atendimento. Além disso, os homens atendidos pelo SAMU, apresentaram 1,5 vezes mais chances de demandar de atendimento de uma USA. Conclusões: A análise mostrou a necessidade da elaboração de ações intersetoriais de promoção e prevenção a saúde relacionado a informação sobre os sinais e sintomas característicos de urgência e emergência.

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Derungs, Nussbaumer, Sommer, Leutenegger, and Furrer. "Frequency of Trainee Operations in General Surgery at a Non-University Teaching Hospital." Swiss Surgery 9, no. 6 (December 1, 2003): 257–62. http://dx.doi.org/10.1024/1023-9332.9.6.257.

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Einleitung: Auch nach Einführung des neuen Weiterbildungsreglements zum Facharzt Chirurgie, stellt die Erfüllung des Operationskatalogs die wohl wichtigste Anforderung dar. Anhand unserer Operationszahlen soll untersucht werden, ob an einer nicht-universitären Ausbildungsklinik der Kategorie A die Facharztanwärter (= Assistenzärzte ohne Facharzt-Titel) mit unserem gegenwärtigen Konzept die geforderten Eingriffe durchführen können. Methode: Für acht Tracereingriffe wurden die Fallzahlen der nicht zusatzversicherten Patienten im Zeitraum 1998-2002 retrospektiv erfasst und bezüglich Weiterbildungsstand des Operateurs untersucht. Das Team umfasste in diesem Zeitraum insgesamt 51 Assistenzärzte (71 Weiterbildungsjahre), davon 18 Facharzt-Anwärter (35 Weiterbildungsjahre, inklusive Rotationen auf die Intensivstation, den Notfall und in andere chirurgische Fachbereiche, wie z.B. die Urologie). Resultate: Bezüglich aller Tracereingriffe werden die Medianwerte (= Anzahl Eingriffe pro Ausbildungsjahr pro Facharztanwärter) erreicht, welche zur Erfüllung des Ausbildungsziels im Sinne der "Chirurgie des Häufigen" nach vier Jahren Weiterbildung nötig sind: Appendektomie 8.9, laparoskopische Cholezystektomie 7.3, offene Inguinalhernienoperation 9.4, Varizenoperation 12.1, offene Sigmaresektion 3.2, Osteosynthesen hüftnahe Fraktur und Malleolarfraktur 6.9, Strumektomie 5.0. Schlussfolgerung: Die Weiterbildungsziele im Hinblick auf die Erfüllung des Operationskataloges wurden erreicht. Mit einer weiterhin konsequenten Umsetzung unseres strukturierten Weiterbildungskonzeptes und gleichbleibenden Fallzahlen dürften die Anforderungen an unsere chirurgische Weiterbildungsstätte auch in Zukunft erfüllt werden können. Noch nicht absehbar ist, inwieweit sich die neuen Arbeitsverträge mit der Arbeitszeitreduktion auf die Facharztausbildung auswirken werden.

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Quanjer, Philip H., André Capderou, Mumtaz M. Mazicioglu, Ashutosh N. Aggarwal, Sudip Datta Banik, Stevo Popovic, Francis A. K. Tayie, Mohammad Golshan, Mary S. M. Ip, and Marc Zelter. "All-age relationship between arm span and height in different ethnic groups." European Respiratory Journal 44, no. 4 (July 25, 2014): 905–12. http://dx.doi.org/10.1183/09031936.00054014.

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The objective of the present study was to establish multiethnic, all-age prediction equations for estimating stature from arm span in males and females.The arm span/height ratio (ASHR) from 13 947 subjects (40.9% females), aged 5–99 years, from nine centres (in China, Europe, Ghana, India and Iran) was used to predict ASHR as a function of age using the lambda, mu and sigma method. Z-scores for forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC in 1503 patients were calculated using measured height and height calculated from arm span and age.ASHR varied nonlinearly with age, was higher in males than in females and differed significantly between the nine sites. The data clustered into four groups: Asia, Europe, Ghana and Iran. Average predicted FEV1, FVC and FEV1/FVC using measured or predicted height did not differ, with standard deviations of 4.6% for FEV1, 5.0% for FVC and 0.3% for FEV1/FVC. The percentages of disparate findings for a low FEV1, FVC and FEV1/FVC in patients, calculated using measured or predicted height, were 4.2%, 3.2% and 0.4%, respectively; for a restrictive pattern, there were 1.0% disparate findings.Group- and sex-specific equations for estimating height from arm span and age to derive predicted values for spirometry are clinically useful.

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Kumar, Anuj, Anukul Jindal, Apurva Singh, Reshma Roy, Om Prakash Kumar, and Tanweer Ali. "A closed modified V-shaped uniplanar triple band ACS fed antenna for wireless applications." Bulletin of Electrical Engineering and Informatics 9, no. 4 (August 1, 2020): 1497–505. http://dx.doi.org/10.11591/eei.v9i4.2148.

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In the proposed paper, a uniplanar asymmetric coplanar strip (ACS) fed antenna with closed V-shaped radiating patch of size printed on FR4 substrate with loss tangent ( =0.02, height (h)=1.6mm, and dielectric constant of 4.4 covering WiMAX, X-band and WLAN applications is presented. The proposed closed V-shaped radiating patch is formed by joning two rectangular stubs. The resultant shape of the radiating patch is obtained by adding rectangular strips to feed line until desired multiband results are achieved. The advantage of this structure is that it forms simple configuration as well as helps the overall antenna in attaining three distinict useful frequency band with good impedance matching for S11-10 dB criteria. The proposed ACS fed antenna operates at 3.1 (WiMAX), 5.0 (WLAN) and 9.9 (X-band) GHz with impedance bandwidth ranging from 2.7-3.9 GHz, 4.4-5.5 GHz and 9.5-10.3 GHz in simulation. Under measurement the proposed antenna shows multiband phenomenon at 3.2, 5.3 and 9.7 GHz with impedance bandwidth ranging from 2.8-3.7 GHz, 4.6-5.4 GHz and 9.4-10 GHz, respectively. The antenna exhibits simulated gain of 2.51, 1.18 and 1.96 dB at the corresponding frequency bands of 3.1, 5.0 and 9.9 GHz. The key parameters of the antenna like length and width of the multi-branched strips are optimized to get the multiband operation. The deisign simulation is carried out in Ansys HFSS (High frequency Simulation Software) where different characteristics of the proposed antenna are investigated. The evolution and optimization process is dealt in detail with the help of S11, VSWR, current distributions, radiation patterns and gain.

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Justo, Edward R., Benjamin M. Reeves, Robert S. Ware, Janelle C. Johnson, Tom R. Karl, Nelson D. Alphonso, and Robert N. Justo. "Comparison of outcomes in Australian indigenous and non-indigenous children and adolescents undergoing cardiac surgery." Cardiology in the Young 27, no. 9 (June 1, 2017): 1694–700. http://dx.doi.org/10.1017/s1047951117000993.

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AbstractBackgroundPopulation-based registries report 95% 5-year survival for children undergoing surgery for CHD. This study investigated paediatric cardiac surgical outcomes in the Australian indigenous population.MethodsAll children who underwent cardiac surgery between May, 2008 and August, 2014 were studied. Demographic information including socio-economic status, diagnoses and co-morbidities, and treatment and outcome data were collected at time of surgery and at last follow-up.ResultsA total of 1528 children with a mean age 3.4±4.6 years were studied. Among them, 123 (8.1%) children were identified as indigenous, and 52.7% (62) of indigenous patients were in the lowest third of the socio-economic index compared with 28.2% (456) of non-indigenous patients (p⩽0.001). The indigenous sample had a significantly higher Comprehensive Aristotle Complexity score (indigenous 9.4±4.2 versus non-indigenous 8.7±3.9, p=0.04). The probability of having long-term follow-up did not differ between groups (indigenous 93.8% versus non-indigenous 95.6%, p=0.17). No difference was noted in 30-day mortality (indigenous 3.2% versus non-indigenous 1.4%, p=0.13). The 6-year survival for the entire cohort was 95.9%. The Cox survival analysis demonstrated higher 6-year mortality in the indigenous group – indigenous 8.1% versus non-indigenous 5.0%; hazard ratio (HR)=2.1; 95% confidence intervals (CI): 1.1, 4.2; p=0.03. Freedom from surgical re-intervention was 79%, and was not significantly associated with the indigenous status (HR=1.4; 95% CI: 0.9, 1.9; p=0.11). When long-term survival was adjusted for the Comprehensive Aristotle Complexity score, no difference in outcomes between the populations was demonstrated (HR=1.6; 95% CI: 0.8, 3.2; p=0.19).ConclusionThe indigenous population experienced higher late mortality. This apparent relationship is explained by increased patient complexity, which may reflect negative social and environmental factors.

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Rashid, Tanweer, Karl Li, Jon B. Toledo, Ilya Nasrallah, Nicholas M. Pajewski, Sudipto Dolui, John Detre, et al. "Association of Intensive vs Standard Blood Pressure Control With Regional Changes in Cerebral Small Vessel Disease Biomarkers." JAMA Network Open 6, no. 3 (March 1, 2023): e231055. http://dx.doi.org/10.1001/jamanetworkopen.2023.1055.

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ImportanceLittle is known about the associations of strict blood pressure (BP) control with microstructural changes in small vessel disease markers.ObjectiveTo investigate the regional associations of intensive vs standard BP control with small vessel disease biomarkers, such as white matter lesions (WMLs), fractional anisotropy (FA), mean diffusivity (MD), and cerebral blood flow (CBF).Design, Setting, and ParticipantsThe Systolic Blood Pressure Intervention Trial (SPRINT) is a multicenter randomized clinical trial that compared intensive systolic BP (SBP) control (SBP target &lt;120 mm Hg) vs standard control (SBP target &lt;140 mm Hg) among participants aged 50 years or older with hypertension and without diabetes or a history of stroke. The study began randomization on November 8, 2010, and stopped July 1, 2016, with a follow-up duration of approximately 4 years. A total of 670 and 458 participants completed brain magnetic resonance imaging at baseline and follow-up, respectively, and comprise the cohort for this post hoc analysis. Statistical analyses for this post hoc analysis were performed between August 2020 and October 2022.InterventionsAt baseline, 355 participants received intensive SBP treatment and 315 participants received standard SBP treatment.Main Outcomes and MeasuresThe main outcomes were regional changes in WMLs, FA, MD (in white matter regions of interest), and CBF (in gray matter regions of interest).ResultsAt baseline, 355 participants (mean [SD] age, 67.7 [8.0] years; 200 men [56.3%]) received intensive BP treatment and 315 participants (mean [SD] age, 67.0 [8.4] years; 199 men [63.2%]) received standard BP treatment. Intensive treatment was associated with smaller mean increases in WML volume compared with standard treatment (644.5 mm3 vs 1258.1 mm3). The smaller mean increases were observed specifically in the deep white matter regions of the left anterior corona radiata (intensive treatment, 30.3 mm3 [95% CI, 16.0-44.5 mm3]; standard treatment, 80.5 mm3 [95% CI, 53.8-107.2 mm3]), left tapetum (intensive treatment, 11.8 mm3 [95% CI, 4.4-19.2 mm3]; standard treatment, 27.2 mm3 [95% CI, 19.4-35.0 mm3]), left superior fronto-occipital fasciculus (intensive treatment, 3.2 mm3 [95% CI, 0.7-5.8 mm3]; standard treatment, 9.4 mm3 [95% CI, 5.5-13.4 mm3]), left posterior corona radiata (intensive treatment, 26.0 mm3 [95% CI, 12.9-39.1 mm3]; standard treatment, 52.3 mm3 [95% CI, 34.8-69.8 mm3]), left splenium of the corpus callosum (intensive treatment, 45.4 mm3 [95% CI, 25.1-65.7 mm3]; standard treatment, 83.0 mm3 [95% CI, 58.7-107.2 mm3]), left posterior thalamic radiation (intensive treatment, 53.0 mm3 [95% CI, 29.8-76.2 mm3]; standard treatment, 106.9 mm3 [95% CI, 73.4-140.3 mm3]), and right posterior thalamic radiation (intensive treatment, 49.5 mm3 [95% CI, 24.3-74.7 mm3]; standard treatment, 102.6 mm3 [95% CI, 71.0-134.2 mm3]).Conclusions and RelevanceThis study suggests that intensive BP treatment, compared with standard treatment, was associated with a slower increase of WMLs, improved diffusion tensor imaging, and FA and CBF changes in several brain regions that represent vulnerable areas that may benefit from more strict BP control.Trial RegistrationClinicalTrials.gov Identifier: NCT01206062

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Chaudhary, Neha, Manmohan Singh Brar, Shradha Mishra, and Avneet Randhawa. "Descriptive profile of patients attending antirabies clinic: a hospital based study of animal bite cases in Patiala." International Journal Of Community Medicine And Public Health 7, no. 6 (May 27, 2020): 2326. http://dx.doi.org/10.18203/2394-6040.ijcmph20202493.

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Background: The word “Rabies” is derived from Latin word ‘Rabus’, which in turn is derived from the Sanskrit word ‘Rabhas’ which means ‘to do violence’. In India, the dog has always existed as the main reservoir of rabies. Globally Asia contributes to highest Rabies mortality; with the highest incidence reported in India followed by China.Methods: A cross-sectional study was conducted at the antirabies clinic during the period of one year (2016-2017). A self-administered, pretested questionnaire was used to extract information on demographic profile, biting animal, nature of biting dog, vaccination status, WHO category of bite, site of bite. Information of 500 animal bite cases were collected during the study period.Results: Maximum cases were reported among children below 15 years age group i.e. 157 (31.4%). Majority reported cases 342 (68.40%) were males and maximum reported cases 338 (67.60%) were from urban area. Majority 472 (94.4%) were bitten by dogs. Approximately two third (66.74%) of the biting dogs were stray while, among the total 157 (33.26%) pet dogs; approximately only one third 59 (37.58%) were vaccinated.Conclusions: Since young children are more at risk of animal bite. So, educational sessions providing knowledge to protect themselves from bites should be a part of School Health Programme. A cooperative approach involving measures like proper garbage disposal, discouraging community owned dogs, helping dog catching squad and sterilization will help to reduce the dog population.

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Kumar, Ch Laxman, D. Sai Chandar, Narendar D, and Shireesha V. "Randomized Placebo-Controlled Clinical Study on the Role of Zinc in Low Birth Weight Neonates." International Journal of Pharmaceutical Sciences and Nanotechnology 7, no. 2 (May 31, 2014): 2423–28. http://dx.doi.org/10.37285/ijpsn.2014.7.2.3.

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Low birth weight (LBW) is one of the important causes of neonatal mortality and morbidity in developing countries. It is hypothesized that LBW neonates are zinc deficient and that might adversely affect postnatal growth. The objective of the investigation was to compare the effect of oral zinc supplementation on growth of low birth weight neonates by randomized controlled trail. 100 LBW neonates between 1501-2499 gm were randomized into zinc and placebo groups. We supplemented zinc 10 mg/day to zinc group and multivitamin drops to placebo group for 28 days. Measure the weight and length according to study schedule. Primary outcome was increment in weight and length and data were analyzed by SPSS. The mean birth weight was 1850 ± 302 gm and 1813 ± 271 gm for zinc and placebo groups, respectively. After 28 days 2595 ± 503 gm with mean weight gain of 26 ± 11 gm/day in zinc group and 2322 ± 472 gm with mean weight gain of 18 ± 9.4 gm/day in placebo group, which was statistically significant (p < 0.001). There was significant length gain (p < 0.001) in zinc group compare to placebo group. Zinc group experienced remarkably less problems like sepsis, duration of hospital stay and jaundice. There were no adverse effects noted in zinc group. Zinc supplementation for LBW neonates was found effective to enhance growth in neonatal period.

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Tinambunan, Deviana, Fanny Silooy, Alfret Luasunaung, Ivor Lembondorong Labaro, Mariana E. Kayadoe, Effendi Pengihutan Sitanggang, Arman Thamin, and Heffry V. Dien. "Mapping of Fishing Areas and Fish Catches by Purse Sine KM. Rebert." Jurnal Ilmiah PLATAX 10, no. 1 (April 14, 2022): 115. http://dx.doi.org/10.35800/jip.v10i1.39694.

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The division of Indonesian waters into several fisheries management areas illustrates very different habitat characteristics and has a diversity of biological resources that may vary. WPPNRI 716 is a management area in Indonesian waters which includes the waters of the Sulawesi Sea and the northern part of Halmahera Island. This research was carried out by the purse seiner KM. Rebert carried out fishing operations in the waters of the Sulawesi Sea at WPPNRI 716. Data collection was carried out for 4 months, namely from October 2021 - to January 2022, with the aim of knowing the distribution area of catching and KM. Rebert catches. KM. Rebet catchment area based on the GPS point is located at WPPNRI 716, which is 81.5 miles from the fishing base (Tumumpa Beach Fishery Port). The number of catches in October (trip 1) was 6350 kg, in October (trip 2) was 4807 kg, in November (trip 3) was 10245 kg, in December (tip 4), was 4234 kg, in December (trip 5) as much as 4280 Kg, in January (trip 6) as many as 2645, and in January (trip 7) 4350 Kg. Judging from the type of catch during the research, there was 13265 kg of mackerel scad (Decapterus sp), then 12953 kg of skipjack tuna (Katsuwonus pelamis L), 4884 kg of yellowfin tuna (Thunnus albacares), and 4100 kg of mackerel tuna (Euthinnus affinis). Selar fish (Selaroides sp) as much as 904 Kg, jackfish (Caranx sp) as much as 500 Kg, rainbow runner fish (Elagatis bipinnulatus) as much as 350 Kg, and the lowest is bullet tuna (Auxis rochei) fish as much as 55 Kg.Keywords: Mapping; KM. Rebert; Purse SeinerAbstrakPembagian wilayah perairan Indonesia ke dalam beberapa kawasan pengelolaan perikanan menggambarkan karakteristik habitat yang sangat berbeda dan memiliki keanekaragaman sumberdaya hayatinya yang dapat saja berbeda. WPPNRI 716 merupakan wilayah pengelolaan di perairan Indonesia yang meliputi perairan Laut Sulawesi dan sebelah Utara Pulau Halmahera.Penelitian ini dilaksanakan kapal pukat cincin (purse seiner) KM. Rebert yang melakukan operasi penangkapan ikan di perairan Laut Sulawesi pada WPPNRI 716. Pengambilan data dilakukan selama 4 bulan yaitu pada bulan Oktober 2021 - Januari 2022, dengan tujuan untuk mengetahui daerah sebaran penangkapan dan hasil tangkapan KM. Rebert. Daerah penangkapan KM. Rebet berdasarkan titik GPS berada pada WPPNRI 716 yang berjarak dari fishing base (Pelabuhan Perikanan Pantai Tumumpa) ± 81,5 mil. Jumlah hasil tangkapan pada bulan bulan Oktober (trip 1) sebanyak 6350 Kg, bulan Oktober (trip 2) sebanyak 4807 Kg, bulan November (trip 3) sebanyak 10245 Kg, bulan Desember (tip 4), sebanyak 4234 Kg, bulan Desember (trip 5) sebanyak 4280 Kg, bulan Januari (trip 6) sebanyak 2645, dan bulan Januari (trip 7) 4350 Kg. Dilihat dari jenis tangkapan selama penelitan adalah ikan layang (Decapterus sp) sebanyak 13265 Kg, kemudian ikan cakalang (Katsuonus pelamis L) sebanyak 12953 Kg, ikan tuna sirip kuning (Thunnus albacares) sebanyak 4884 Kg, ikan tongkol (Auxis rochei) sebanyak 4100 Kg ikan selar (Selaroides sp) sebanyak 904 Kg, ikan kuwe (Caranx sp) sebanyak 500 Kg, ikan sunglir (Elagatis bipinnulatus) sebanyak 350 Kg, dan yang paling rendah adalah ikan tongkol (Auxis rochei) sebanyak 55 Kg.Kata Kunci:Pemetaan; KM. Rebert; Pukat Cincin.

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Ognerubov, Dmitrii V., Alexander Sedaghat, Sergey I. Provatorov, Andrey S. Tereshchenko, Olivier F. Bertrand, Ivo Bernat, Goar K. Arutyunyan, et al. "A Randomized Trial Comparing Short versus Prolonged Hemostasis with Rescue Recanalization by Ipsilateral Ulnar Artery Compression: Impact on Radial Artery Occlusion—The RESCUE-RAO Trial." Journal of Interventional Cardiology 2020 (October 22, 2020): 1–7. http://dx.doi.org/10.1155/2020/7928961.

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Background. Despite the enormous benefits of radial access, this route is associated with a risk of radial artery occlusion (RAO). Objective. We compared the incidence of RAO in patients undergoing transradial coronary angiography and intervention after short versus prolonged hemostasis protocol. Also we assessed the efficacy of rescue 1-hour ipsilateral ulnar artery compression if RAO was observed after hemostasis. Material and Methods. Patients referred for elective transradial coronary procedures were eligible. After 6 F radial sheath removal, patients were randomized to short (3 hours) (n = 495) or prolonged (8 hours) (n = 503) hemostasis and a simple bandage was placed over the puncture site. After hemostasis was completed, oximetry plethysmography was used to assess the patency of the radial artery. Results. One thousand patients were randomized. Baseline characteristics were similar between both groups with average age 61.4 ± 9.4 years (71% male) and PCI performed on half of the patients. The RAO rate immediately after hemostasis was 3.2% in the short hemostasis group and 10.1% in the prolonged group ( p < 0.001 ). Rescue recanalization was successful only in the short group in 56.2% (11/19); at hospital discharge, RAO rates were 1.4% in the short group and 10.1% in the prolonged group ( p < 0.001 ). Conclusion. Shorter hemostasis was associated with significantly less RAO compared to prolonged hemostasis. Rescue radial artery recanalization was effective in > 50%, but only in the short hemostasis group.

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