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Academic literature on the topic '34A55'

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Published: 1 June 2024

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Journal articles on the topic "34A55":

1

Hammad, Ma’mon Abu, Waseem Ghazi Alshanti, Ahmad Alshanty, and Roshdi Khalil. "Tensor Product Technique and Atomic Solution of Fractional Partial Differential Equations." Journal of Applied Mathematics 2024 (May 20, 2024): 1–4. http://dx.doi.org/10.1155/2024/7607714.

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In this paper, we investigate the atomic solution of a special type of fractional partial differential equations. Tensor product in Banach spaces, some properties of atom operators, and some properties of conformable fractional derivatives are utilized in such process.JEL Classification: 34G10, 34A55
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Yun, D., and Z. X. Yin. "3455." Ultrasound in Medicine & Biology 32, no. 5 (May 2006): P269. http://dx.doi.org/10.1016/j.ultrasmedbio.2006.02.1227.

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Adiningsih, Yuni, and Nami Lestari. "Peningkatan Kandungan Yodium pada Es Krim dari Rumput Laut Euchema Cottonii." Jurnal Riset Teknologi Industri 8, no. 15 (August 25, 2016): 18–26. http://dx.doi.org/10.26578/jrti.v8i15.1549.

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The purpose of this research is to increase the iodine content of processed foods such as ice cream with the addition of seaweed variations Euchema cotonii. Seaweed is one of the food sources that contain high fiber and iodine so good for health. Variables research done by adding seaweed to the dough ice cream with the amount of 25%, 50% and 75%. The test results showed the water content, protein, fat concentration increases with seaweed. Test results proximat ie water content ranged 34.55% -37.15%, protein 1.6% -4% range, fat 20.25% - 26.45 % range, ranged from 20.6 to 22.6% carbohydrate. The addition of seaweed showed elevated levels of iodine which is quite high due to the amount of seaweed is added. Test results iodine levels without seaweed ice cream of 2.07 ppm to 19.91 ppm with the addition of seaweed as much as 75%. Test hedonic/A indicates aroma, color, texture and taste almost preferred by the panelists. ABSTRAKTujuan penelitian ini adalah melakukan peningkatan kandungan yodium pada olahan pangan berupa es krim dengan variasi penambahan rumput laut jenis Euchema Cotonii. Rumput laut merupakan salah satu sumber bahan pangan yang mengandung serat dan yodium yang tinggi sehingga baik untuk kesehatan. Variabel penelitian dilakukan dengan penambahan rumput laut ke dalam adonan es krim dengan jumlah 25%, 50% dan 75%. Hasil uji menunjukan kadar air, protein, lemak meningkat seiring dengan bertambahnya konsentrasi rumput laut. Hasil uji proximat yaitu kadar air berkisar 34,55%-37,15%, protein berkisar 1,6%-4%, lemak berkisar 20,25%-26,45%, karbohidrat berkisar 20,6-22,6%. Penambahan rumput laut menunjukan peningkatan kadar yodium yang cukup tinggi seiring dengan jumlah rumput laut yang ditambahkan. Hasil uji kadar yodium es krim tanpa rumput laut sebesar 2,07 ppm menjadi 19,91 ppm dengan penambahan rumput laut sebanyak 75%. Uji hedonik/kesukaan menunjukan aroma, warna, tekstur dan rasa hampir disuka oleh panelis. Kata kunci : es krim, rumput laut Euchema Cottonii, yodium
4

Glantz, David M. "Red army motorization and mechanization program 1930–34155." Journal of Soviet Military Studies 3, no. 1 (March 1990): 135–55. http://dx.doi.org/10.1080/13518049008429977.

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da Costa, Marta. "Teaching Global Citizenship: A Canadian Perspective, Lloyd Kornelsen, Geraldine Balzer and Karen M. Magro (Eds) (2020)." Citizenship Teaching & Learning 18, no. 2 (June 1, 2023): 263–65. http://dx.doi.org/10.1386/ctl_00124_5.

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Review of: Teaching Global Citizenship: A Canadian Perspective, Lloyd Kornelsen, Geraldine Balzer and Karen M. Magro (Eds) (2020) Toronto and Vancouver: Canadian Scholars’ Press, 228 pp., ISBN 978-1-77338-198-5, p/bk, £34.55
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Mohanty, Vakul, Natalia Baran, Yuefan Huang, Shan He, Ramiz Iqbal, Jeffrey Tyner, Gordon Mills, Marina Konopleva, and Ken Chen. "Abstract 3455: Transcriptional and phenotypic heterogeneity underpinning venetoclax resistance." Cancer Research 83, no. 7_Supplement (April 4, 2023): 3455. http://dx.doi.org/10.1158/1538-7445.am2023-3455.

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Abstract Venetoclax (VEN), an inhibitor of anti-apoptotic protein BCL2 is an important therapeutic intervention in acute myeloid leukemia (AML). However, development of resistance to VEN and its combinations is common, which poses a significant clinical challenge to the management of AML. Heterogeneity in resistance can exist not only across different tumors but also within the same tumor. While some mechanisms of resistance have been revealed, others remain elusive. Here, we derive a VEN resistance signature from AML cell-lines in CCLE, and utilize non-negative matrix factorization to decompose the signature and systematically define four transcriptionally distinct clusters of VEN resistant AML patient using the BeatAML cohort, consisting of 186 patients. By integrating gene expression and drug response profiles from these patients, we elucidate distinct expression programs underlying VEN resistance in these clusters and their associated vulnerabilities. Samples in Cluster 1 are characterized by high frequency of DNMT3A and RAS (KRAS and NRAS) mutations, strong monocytic phenotype and high PI3K-mTOR signaling, oxidative phosphorylation (OXPHOS) and fatty acid metabolism, indicating improved metabolic fitness. These samples also show remarkable sensitivity to panobinostat, an HDAC inhibitor, which suppresses mTORC1 signaling and OXPHOS. Cluster 3, in contrast, is characterized by TP53 and SRSF2 mutations, high CTL infiltration and activation of JAK-STAT and MAPK signaling, which regulate pro-survival pathways and proliferation. They also show selective sensitivity to JAK family inhibitors. Cluster 3-like AML cell-lines also show remarkable sensitivity to the JAK inhibitor, ruxolitinib. Cluster 2 samples exhibit high rates of NRAS mutations and suppression of HOX genes. Finally, Cluster 4 samples are transcriptionally similar to VEN sensitive patients, but show higher interferon signaling and higher rates of DNMT3A and IDH1 mutations. We validated these clusters using the TCGA AML (n=173) and a second BeatAML cohort (n=182).We further confirmed the existence and therapeutic value of these clusters by projecting them onto single-cell RNA-seq data obtained from a patient before and after VEN+azacitidine treatment. In pre-treatment cells, both VEN sensitive (41%) and resistance (59%) signatures were present in the patient tumor, however, post-treatment we observed that Cluster 1 (5%) and Cluster 2 (93%) like resistant cells accounted for most of the tumor cells. While Cluster 1 like cells were characterized by activation of metabolic pathways, the more proliferative Cluster 2 like cells dominated the tumor after relapse. Our study systematically identified and characterized mechanistic heterogeneity in venetoclax resistant AMLs and can aid therapeutic decision making and development of effective combination therapies with venetoclax. Citation Format: Vakul Mohanty, Natalia Baran, Yuefan Huang, Shan He, Ramiz Iqbal, CTD2 consortium, Jeffrey Tyner, Gordon Mills, Marina Konopleva, Ken Chen. Transcriptional and phenotypic heterogeneity underpinning venetoclax resistance [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3455.
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Lehrman, Sally. "Nobel laureates in bid to revamp science teaching." Nature 391, no. 6663 (January 1998): 113. http://dx.doi.org/10.1038/34255.

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Cambón, María Isabel, and Gema Pedrón. "Herramientas macroprudenciales en el ámbito de los fondos de inversión abiertos." Revista de Estabilidad Financiera, Número 45 (otoño 2023) (December 4, 2023): 51–76. http://dx.doi.org/10.53479/34855.

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La relevancia que han cobrado las entidades y actividades financieras no bancarias en los últimos años ha centrado la atención de supervisores y reguladores a efectos de preservar la estabilidad financiera. Se ha iniciado un debate a escala internacional sobre la conveniencia de desarrollar la política macroprudencial en el ámbito de los fondos de inversión. Los riesgos más importantes para la estabilidad financiera que pueden emanar de estas instituciones se originan, principalmente, por los desajustes entre las condiciones de liquidez de su cartera y las de sus reembolsos o por un apalancamiento elevado. Las herramientas macroprudenciales disponibles en este ámbito son múltiples y de diferente naturaleza, y existe una gran disparidad entre las jurisdicciones. Actualmente están en marcha relevantes iniciativas internacionales, impulsadas por la Organización Internacional de Comisiones de Valores y el Consejo de Estabilidad Financiera, destinadas a promover y homogeneizar el conjunto de herramientas disponibles y su aplicación. En este artículo se describen las herramientas existentes en España, detallando el objetivo que persiguen y la posibilidad de acción por parte del regulador. Asimismo, se compara la situación de España con la de otras jurisdicciones europeas. La comparativa revela la amplia disponibilidad en España tanto de información como de herramientas para la gestión de los riesgos.
9

Hosted, Thomas J., Tim Wang, and Ann C. Horan. "Characterization of the Streptomyces lavendulae IMRU 3455 linear plasmid pSLV45." Microbiology 150, no. 6 (June 1, 2004): 1819–27. http://dx.doi.org/10.1099/mic.0.26994-0.

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Streptomyces lavendulae IMRU 3455 contains two large linear plasmids designated pSLV45 (45 kb) and pSLV195 (195 kb). A cosmid, pSPRX604, containing 42 kb from pSLV45 was cloned and sequenced. pSLV45 was tagged with a hygromycin-resistance marker by homologous recombination to generate the derivatives pSLV45.680 and pSLV45.681. An apramycin-resistance marker was introduced into S. lavendulae IMRU 467 using the pSPR910 integration vector to yield the recipient strain SPW910. The self-transmissible nature of pSLV45 was determined by transfer of pSLV45.680 and pSLV45.681 from the donor strains SPW680 and SPW681 into the recipient strain SPW910. Southern analysis indicated the presence of hygromycin- and pSLV45-hybridizing sequences within SPW910 exconjugants. PFGE analysis confirmed pSLV45.680 and pSLV45.681 were transferred intact and formed freely replicating linear plasmids. Sequence analysis of pSPRX604 revealed genes predicted to be involved in plasmid transfer, partitioning and regulation. The transfer of the linear plasmid pSLV45 from S. lavendulae IMRU 3455 into S. lavendulae IMRU 467 may allow the development of pSLV45 as an actinomycete-to-actinomycete conjugative shuttle vector.
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Romisher, Alison, Alexa Cohen, and Elizabeth Jones. "34255 Disparity exists between urban versus rural reach of teledermatology following COVID-19." Journal of the American Academy of Dermatology 87, no. 3 (September 2022): AB43. http://dx.doi.org/10.1016/j.jaad.2022.06.207.

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Journal articles Dissertations / Theses Books

Dissertations / Theses on the topic "34A55":

1

Janati, Hicham. "Advances in Optimal transport and applications to neuroscience." Electronic Thesis or Diss., Institut polytechnique de Paris, 2021. http://www.theses.fr/2021IPPAG001.

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Les dispositifs d'imagerie cérébrale peuvent donner un aperçu de l'activité neuronale à plusieurs endroits et points dans le temps. En pratique, les études d'imagerie cérébrales sont généralement menées pour plusieurs personnes suivant le même protocole expérimental. L'inférence des régions actives du cerveau est un problème inverse mal posé qui ne peut être résolu qu'en ajoutant des hypothèses a priori sur les solutions. Plusieurs hypothèses préalables ont été poursuivies dans la littérature, comme la favorisation des solutions parcimonieuses ou la résolution du problème pour plusieurs sujets à la fois. Cependant, aucune ne profite de la géométrie spatiale du problème. Le but de cette thèse est d'exploiter au maximum les aspects multisujets, spatiaux et temporels des données de magnétoencéphalographie pour améliorer le conditionnement du problème inverse. À cette fin, nos contributions s'articulent autour de trois axes : le transport optimal (OT), la régression multi-tâches parcimonieuse et les séries temporelles. En effet, la capacité de l'OT à mesurer les disparités spatiales entre les distributions le rend très bien adapté à la comparaison et l'aggrégation des cartes d'activation neurales en fonction de leur forme et de leur emplacement sur la surface du cortex cérébral. Pour des raisons numériques, on utilise la formulation entropique du transport optimal, qui, selon nous, comporte deux pièces manquantes importantes. D'un point de vue théorique, elle n'a aucune expression analytique à ce jour, et d'un point de vue pratique, l'entropie conduit à une augmentation significative de la variance, phénomène connu sous le nom de biais entropique. Nous complétons ce puzzle en étudiant les Gaussiennes multivariées pour lesquelles nous découvrons une forme close de l'OT entropique et proposons des algorithmes débiaisés pour calculer des barycentres de transport optimal rapides et précis. Ensuite, nous définissons une pénalité multitâche basé sur l'OT et des pénalités de parcimonie pour résoudre le problème inverse pour plusieurs sujets afin de promouvoir des solutions cohérentes sur le plan spatial. Nos résultats sur des données réelles mettent en évidence les avantages de l'utilisation de l'OT comme régularisation par rapport aux pénalités de régression multitâches classiques. Enfin, nous proposons une nouvelle divergence pour comparer et moyenner des données spatio-temporelles basée sur un alignement temporel entre des observations spatialement similaires, le tout via un algorithme rapide et adapté aux GPUs
Brain imaging devices can provide a glimpse at neural activity in multiple spatial locations and time points. Moreover, neuroimaging studies are usually conducted for multiple individuals undergoing the same experimental protocol. Inferring the underlying sources is a challenging inverse problem that can only be tackled by biasing the solutions with prior domain knowledge. Several prior hypotheses have been pursued in the literature such as promoting sparse over dense solutions or solving the problem for multiple subjects at once. However, none take advantage of the particular spatial geometry of the problem. The purpose of this thesis is to exploit the multi-subject, spatial and temporal aspects of magneto-encephalography data as much as possible to improve the conditioning of the inverse problem. To that end, our contributions revolve around three axes: optimal transport (OT), sparse multi-task regression and time series. Indeed, the ability of OT to capture spatial disparities between measures makes it very well suited to compare and average neural activation patterns based on their shape and location over the cortical surface of the brain. For the sake of scalability, we take advantage of the entropic formulation of optimal transport, which we argue has two important missing pieces. From a theoretical perspective, it has no closed form analytical expressions, and from a practical perspective, entropy leads to a significant increase in variance known as "entropic bias". We complete this puzzle by studying multivariate Gaussians for which we uncover an entropic OT closed form and propose "debiased" algorithms to compute fast and accurate optimal transport barycenters. Second, we define a multi-task prior based on OT and sparse penalties to jointly solve the inverse problem for multiple subjects to promote spatially coherent solutions. Our real data experiments highlight the benefits of using OT as a prior over classical multi-task regression penalties. Finally, we propose a loss function to compare and average spatio-temporal data that computes temporal alignments across spatially similar observations of the data via a fast GPU friendly algorithm
2

Dumenil, Sylvie. "Influence de concentrations subinhibitrices d'amikacine sur l'activité élastolytique de"Pseudomonas aeruginosa" IFO 3455." Paris 5, 1991. http://www.theses.fr/1991PA05P101.

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Farghal, Aser Soliman Ahmed. "Physiological MR imaging of small bowel : implementation, validation and interpretation." Thesis, University of East Anglia, 2011. https://ueaeprints.uea.ac.uk/34255/.

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Holmes, Christopher. "Economistic fallacies in contemporary capitalism : a Polanyian analysis of regimes of marketised social protection." Thesis, University of Warwick, 2010. http://wrap.warwick.ac.uk/34555/.

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Karl Polanyi used the notion of economistic fallacy in order to flag up the way in which formal definitions of the economy – rooted in the assumption of economising, self-interested market behaviour – were routinely applied as universal and rational by economists, political scientists, policy makers and in general public discourse. This thesis is a critical re-application of the notion of economistic fallacy in theoretical, historical and contemporary perspective. I argue that, although Polanyi’s broad generalisations are unsuitable for contemporary analysis, the same basic type of fallacy can be observed in various specific policy settings. Roughly speaking, the thesis comprises two halves. In the first, I focus on theoretical matters, arguing for a consideration of Polanyi specifically as a political economist of ideas. This, I argue, gets us closer to some of Polanyi’s most interesting analytical intentions whilst freeing us from some of the apparent ontological contradictions latent in his various texts. From there, I develop Polanyi’s insights on the role of ideas in capitalist development, foregrounding the notion of economistic fallacy as a key conceptual device. In the second half of the thesis, I apply this analysis over three case studies, one on global financial regulation, one on climate change and one on welfare provision in the UK. These areas are chosen as contemporary reflections of the three ‘fictitious commodities’ that Polanyi identified as uniquely important loci of economistically fallacious logics, namely money, land and labour. In each case, I note how specific versions of economistic fallacy have guided policies that aim to deliver forms of social protection via market mechanisms and market actors – what I call ‘marketised social protection’. This is in distinction to the straightforward (often state-led) societal self-protection that Polanyi and latter-day Polanyians have typically focused upon. I argue that the policies discussed are economistically fallacious to the extent that they rely on unrealistic, overly rationalist assumptions about the nature of society, the natural environment and people, respectively. I show instead how the dynamics of capital accumulation that such regimes serve to legitimate and protect – dynamics that I refer to as forms of ‘market self-protection’ – act to continually undermine the success of such policy programmes. This, I argue, is a distinctive tension in the ideational and material landscape of contemporary capitalism.
5

Eaton, Natasha Jane. "Imaging Empire : the trafficking of art and aesthetics in British India c.1772 to c.1795." Thesis, University of Warwick, 2000. http://wrap.warwick.ac.uk/34755/.

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This dissertation explores the complex entanglements of an artistic traffic between two distinct 'visual economies' in eastern India, c.1772-c.1795. Both late Mughal and early colonial cultures were undergoing transformation, to the extent that during this era the nascent colonial artistic diaspora collapsed. Three inter-related areas will be interrogated: the prestation and commercial circulation of imagery between London, Calcutta and Murshidabad, the dichotomies of political and aesthetic spheres, and colonial representations of late Mughal culture as embroiled by such frameworks. Chapter one examines India-painted subjects in a metropolitan aesthetic sphere, thus acting as crucial juxtaposition for the refiguration of British art in Calcutta, which is the subject of the following section. Hastings' regime wielded British art as part of an intensely spectacular colonial governmentality, but his successor Cornwallis, took a tougher line with devastating effect. A diversity of competing, derivative idioms ousted professional colonial painting forever; its artistic schema penetrated to 'grass-roots' level through the creation of a 'Company School' which transposed the practice of the patua caste. Chapters five to seven investigate nawabi perceptions of British imagery. Hastings introduced the gifting of large-scale portraits; artefacts ill-suited to Indian interiors and aesthetic interiority - perhaps not even viewed as 'art'. The final chapter, through representations of the nawabs of Murshidabad and Lucknow, traces the evolution of British pictures as accoutrements of Mughal sovereignty. By 1795 both courts possessed permanent if 'hybrid' expositions of colonial imagery which transgressed established Indian and British classifications, as well as indicating more profound redefinitions of Indian comportment, consumption and taste. The intersection of 'visual economies' by way of an exploration of diverse zones of transculturation and processes of translation, provides a vital lens for recovering Indian and British agency - both elite and subaltern, in the oft-uneasy formation of a colonial aesthetic forum.
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Chryssochoidis, George. "Rolling out new products across international markets : causes of delays." Thesis, University of Warwick, 1997. http://wrap.warwick.ac.uk/34655/.

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The problem of delays in product rollout becomes more unwieldy for new products that are being launched across many countries. This concern rises when firms operate in rapid technological change and high internationalisation business environments. This study aims to form an empirically based body of knowledge about rollout of new products across international markets, build strong theory and provide insights for better practice. The study focuses on both static and dynamic aspects of the management of new product rollout across international markets. The investigation considers an extensive set of variables describing the company's external and internal environment, as well as the company's action across borders. It attempts more precisely to identify: - whether timeliness in new product rollout relates to new product success; - whether companies roll out new products across their international markets simultaneously or sequentially; and - the factors that lead to delay in rollout schedules and their interaction. A six-phase research methodology was designed and implemented. These phases were: (1) a review of literature across several streams of research; (2) a pilot telephone interview study; (3) exploratory interviews in 6 companies and a preliminary cross-case analysis; (4) the refinement of methodological and theoretical framework issues; (5) an additional series of research interviews in 24 more companies; and (6) a second cross-case analysis. These were followed by the formulation of a model and the estimation of the magnitude of direct, indirect and total effects of each factor upon rollout timeliness. The main findings were: - Timely rolled-out projects were far more successful than delayed rolled-out projects. - Sequential new product rollouts were more frequent than simultaneous ones. Delays were consistently featured in the cases of sequential new product rollouts. - The main factors that lead to delay in rollout schedules were: insufficiency of marketing and technological resources, poor internal communications between the HQ and the country markets, lack of synergies in product handling by the sales force in both the HQ and the country markets, lack of synergies in customer familiarity with the product, lack of proficiency in the new product development process and a deficient product.
7

Goff, M. "A critical investigation of electronic patient records in the NHS in England : tracing an elusive object through its actor-network." Thesis, University of Salford, 2014. http://usir.salford.ac.uk/34355/.

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This study is a critical investigation of electronic patient records in the National Health Service in England. It explores whether EPRs benefit clinicians in the context of a technology that has been explicitly designed to fulfil multiple purposes, both clinical and non-clinical, and is critical in its motivation to challenge their apparent sense of inevitability. Against the backdrop of a government vision of a nationally networked EPR the research takes a meso level perspective using primary data from interviews with users across multiple NHS Trusts and healthcare settings. The study uses Actor-Network Theory from the outset as both a methodological and theoretical approach with the aim to be revelatory about the interests at work in sustaining this technology and to question whether clinicians bear the costs of network-building for the EPR. This has shaped the trajectory of the research, which is as a consequence highly reflexive and in which theoretical and methodological concerns are given equal weight to investigation of EPRs. Whilst EPRs undoubtedly benefit clinicians fundamentally through improved access to patient information, benefits are constrained by material and social interests that reproduce existing relations. In particular, non-clinical agendas are strongly inscribed within EPRs, reshaping clinical work practices by defining what may and must be recorded, and shifting attention within clinical care. A performative conception of EPRs acknowledges the messy and multiple realities and enables theorisation of the technology as complicit in a reshaping of reality towards informatized healthcare. EPRs mediate a quantification of clinical practice that implies additional work for clinicians, and new regimes of control based around recording in the EPR. The study paints a complex and subtle picture of the use of EPRs by mapping its actor-network through the experiences of users and conceptualising the EPR as emerging from a messy, heterogeneous network of socio-material relations.
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Kaewkangsadan, Viriya. "Evaluation of immune cell infiltrates and expression of cytokines/biological molecules in the microenvironment of tumours and tumour-draining axillary lymph nodes in patients with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy : crucial contribution to immune-mediated tumour cell death." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/34155/.

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Background: Neoadjuvant chemotherapy (NAC) is being used as first line treatment in women with large and locally advanced breast cancers (LLABCs). However, the response to NAC is difficult to predict. Growing evidence suggests that these patients are immunosuppressed and that circulating immunosuppressive regulatory cells and humoral factors affect the response to NAC. We explored the possible role of the in situ tumour immune milieu in inducing and affecting the responses to NAC, and the contribution of concomitant systemic circulating regulatory cells. Methods: Paraffin-embedded breast cancers and ipsilateral axillary lymph nodes (ALNs) from pre- and post-NAC samples of a cohort of 33 women with LLABCs, 16 of whom had their blood regulatory cells previously investigated. Various immune cell infiltrations and expression of cytokines/biological molecules in the specimens were studied using appropriate monoclonal antibodies and immunohistochemistry. Statistical analysis was carried out using non-parametric tests with SPSS version 21. Results: High levels of pre-NAC tumour-infiltrating lymphocytes (TILs) (p < 0.001) and subsets of CD4⁺T cells (intratumoural, p=0.023; peritumoural, p=0.001), CD8+T cells (intratumoural, p=0.008; peritumoural, p=0.002) and CD56⁺NK cells (intratumoural, p=0.001; peritumoural, p < 0.001) were significantly associated with a pathological complete response (pCR). High levels of CD163⁺macrophages were also significantly associated with a good pathological response (p=0.004) and pCR (p=0.008). There was a positive correlation between the CD8:FOXP3 ratio and grade of pathological response. In multivariate analyses, TILs and peritumoural CD56+NK cells were found to be independent predictive factors for pCR. There was a significantly high expression of IL-10 in post-NAC breast specimens with poor responses to NAC (p < 0.001). NAC significantly reduced infiltrating T regulatory cells (Tregs) (p=0.001) and PD1⁺T cells (p=0.005), as well as expression of IL-4 (p=0.016). There was no significant difference between the percentages (%) of immune cells present in ALNs with or without metastases but there was a T helper-2 cytokine polarisation in metastatic ALNs. Metastatic ALNs with a high % of CD8+T cells (p=0.048) and low % of FOXP3+Tregs (p=0.019) were significantly associated with an ALN pCR. There was a significantly positive correlation between circulating and intratumoural infiltrating Tregs following NAC (p=0.003). Conclusions: The tumour immune microenvironment is a key factor in achieving a good pathological response with NAC. Tumour and blood immune parameters may be clinically useful in identifying women with LLABCs likely to respond to NAC. Our findings also suggest that the beneficial effects of NAC are mediated via modulation of anticancer immunity, in particular by reduction of T regulatory cells and immunosuppressive humoral factors.
9

Mewar, Devesh. "Studies on autoantigens in rheumatoid arthritis." Thesis, University of Sheffield, 2003. http://etheses.whiterose.ac.uk/3455/.

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This thesis describes the use of phage display for the isolation of autoantigens in rheumatoid arthritis. The potential of the technology is demonstrated by the isolation of an autoantigen, eukaryotic translation elongation factor 1a1 (eEF 1 (x 1)) from a fibroblast cDNA library using rounds of selective enrichment with IgG from RA patients. Subsequently in order to isolate joint-specific antigens a phage-displayed cDNA library from rheumatoid pannus was generated and screened with analogous procedures. From the clones isolated, putative candidate autoantigens were identified. The presence of anti- eEF 1a1 autoantibodies in approximately 20% of patients with RA was confirmed and extended in larger panels of sera, and the finding of anti-eEF la1 shown to be relatively specific for RA. In contrast autoantibodies to the activation-induced negative regulator of T cells, CTLA-4 were not found in contrast to a previous report. The relevance of these findings for the use of antibodies in the diagnosis and prediction of disease characteristics in RA are discussed.
10

Freier, De Ferrari Luisa Feline. "A reverse migration paradox? : policy liberalisation and new south-south migration to Latin America." Thesis, London School of Economics and Political Science (University of London), 2016. http://etheses.lse.ac.uk/3455/.

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In past decades, immigration policies in Latin America developed in stark contrast to other regions. Whereas most countries moved towards more restrictive policies, many Latin American countries liberalised their immigration policy frameworks and recently passed laws that expand individual rights in unprecedented ways. At the same time, migratory movements in Latin America are in flux, one of the most noteworthy recent developments being the increase in extra-continental immigration from Africa, Asia and the Caribbean. This PhD explores a reverse migration paradox inherent in the reciprocal causal relationship between immigration policy liberalisation and new south-south migration. The first paper uses a mixed approach of legal analysis and process tracing to show this paradox in the cases of Argentina, Brazil and Ecuador. It analyses the tension between liberal discourses and policies that invoke the universality of migrants’ rights and free human mobility, on the one hand, and the rejection of recently increasing irregular south–south migration on the other. Using a difference-in-difference design, the second paper tests the impact of Ecuador’s policy of visa freedom of 2008 on previously restricted countries in Asia, Africa and the Caribbean, and shows that immigration from these regions more than doubled. Qualitative findings confirm that visa freedom was the main determinant of migrants’ decision to move to Ecuador and further show great variance of migrant characteristics. The third paper is based on 35 in-depth interviews, which collectively demonstrate that perceived security threats of domestic and international political actors, which led to the partial reintroduction of tourist visa requirements for ten African and Asian countries by 2010, were closely intertwined with racism. Taken together, the three papers have important implications for the study of immigration policies, south-south migration and the securitisation of migration.
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Books on the topic "34A55":

1

Collado, Faustino. Legislacion municipal: Relación, clasificación y síntesis : Ley 3455 de organización municipal. Herrera, Santo Domingo: Union de Vecinos Activos (UVA), 1997.

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Administration, United States Congress House Committee on House. Mahatma Gandhi memorial: Report (to accompany H.R. 3455) (including cost estimate of the Congressional Budget Office). [Washington, D.C.?: U.S. G.P.O., 1988.

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United States. Congress. House. Committee on House Administration. Mahatma Gandhi memorial: Report (to accompany H.R. 3455) (including cost estimate of the Congressional Budget Office). [Washington, D.C.?: U.S. G.P.O., 1988.

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United States. Congress. House. Committee on House Administration. Mahatma Gandhi memorial: Report (to accompany H.R. 3455) (including cost estimate of the Congressional Budget Office). [Washington, D.C.?: U.S. G.P.O., 1988.

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Nielsen, Laura Beth, and Robert L. Nelson, eds. Handbook of Employment Discrimination Research. Dordrecht: Springer Netherlands, 2005. http://dx.doi.org/10.1007/1-4020-3455-5.

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Emmermacher, Julia. 3D-Druck mit lebenden Zellen. Wiesbaden: Springer Fachmedien Wiesbaden, 2021. http://dx.doi.org/10.1007/978-3-658-34455-9.

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Schumann, René, Stefan Oswald, and Philippe Gillen. Verhandeln mit System. Wiesbaden: Springer Fachmedien Wiesbaden, 2021. http://dx.doi.org/10.1007/978-3-658-34055-1.

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Frank-Fahle, Constantin, and Roland Falder. Quick Guide Grenzüberschreitender Mitarbeitereinsatz. Wiesbaden: Springer Fachmedien Wiesbaden, 2021. http://dx.doi.org/10.1007/978-3-658-34855-7.

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Engelen, Andreas, Clara von Gagern, and Monika Engelen. Opportunity Recognition. Wiesbaden: Springer Fachmedien Wiesbaden, 2021. http://dx.doi.org/10.1007/978-3-658-34955-4.

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Jürgensen, Silke M. Ende der Machtposition!? Wie Mitarbeiterführung wirklich gelingt. Wiesbaden: Springer Fachmedien Wiesbaden, 2021. http://dx.doi.org/10.1007/978-3-658-34355-2.

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Book chapters on the topic "34A55":

1

Kumar, M. "3455 Chemical Shifts and Coupling Constants for C15H21N6PS3." In Chemical Shifts and Coupling Constants for Phosphorus-31, 3464. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-32069-9_3457.

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Donohue, John J., and Peter Siegelman. "The Evolution of Employment Discrimination Law in the 1990s: A Preliminary Empirical Investigation." In Handbook of Employment Discrimination Research, 261–84. Dordrecht: Springer Netherlands, 2005. http://dx.doi.org/10.1007/1-4020-3455-5_13.

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Cottier, Thomas. "Towards a Common External Economic Policy of the European Union." In Common Commercial Policy after Lisbon, 3–15. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-34255-4_1.

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Brown, Colin M. "Changes in the Common Commercial Policy of the European Union After the Entry into Force of the Treaty of Lisbon: A Practitioner’s Perspective." In Common Commercial Policy after Lisbon, 163–83. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-34255-4_10.

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Hindelang, Steffen. "The Autonomy of the European Legal Order." In Common Commercial Policy after Lisbon, 187–98. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-34255-4_11.

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Lavranos, Nikolaos. "Designing an International Investor-to-State Arbitration System After Opinion 1/09." In Common Commercial Policy after Lisbon, 199–219. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-34255-4_12.

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Rovetta, Davide. "Investment Arbitration in the EU After Lisbon: Selected Procedural and Jurisdictional Issues." In Common Commercial Policy after Lisbon, 221–33. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-34255-4_13.

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Ziegler, Andreas R. "The New Competence of the European Union in the Area of Foreign Direct Investment (FDI): A Third Country Perspective." In Common Commercial Policy after Lisbon, 235–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-34255-4_14.

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Terhechte, Jörg Philipp. "(National) Constitutional Law Limitations on the Advancement of the EU’s Common Commercial Policy." In Common Commercial Policy after Lisbon, 19–28. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-34255-4_2.

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Weiß, Wolfgang. "Common Commercial Policy in the European Constitutional Area: EU External Trade Competence and the Lisbon Decision of the German Federal Constitutional Court." In Common Commercial Policy after Lisbon, 29–47. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-34255-4_3.

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Conference papers on the topic "34A55":

1

"Pages 3452 - 3455 intentionally left blank." In IGARSS 2004. 2004 IEEE International Geoscience and Remote Sensing Symposium. IEEE, 2004. http://dx.doi.org/10.1109/igarss.2004.1370449.

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"Selección de proyectos de inversión en actuaciones de energías renovables mediante el Proceso Analítico en Red (ANP) combinado con DEMATEL." In 27th International Congress on Project Management and Engineering. Asociación Española de Dirección e Ingeniería de Proyectos (AEIPRO), 2023. http://dx.doi.org/10.61547/3455.

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Walker, Alice M., Jacqueline J. Stevens, and Paul B. Tchounwou. "Abstract 3455: Arsenic trioxide modulates DNA synthesis and apoptosis in lung carcinoma cells." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3455.

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Huang, Wen-Chien. "Abstract 3455: Biologic functions of BMX/BTK in non-small cell lung cancer." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-3455.

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Wallin, Hanna, Kersti Alm, and Magnus Abrahamson. "Abstract 3455: Cystatin C decreases proliferation of melanoma cells by affecting mitosis length." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-3455.

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Rezapour, Shabnam, Janet K. Allen, and Farrokh Mistree. "Uncertainty Propagation in a Supply Chain / Network With Uncertain Facility Performance." In ASME 2014 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/detc2014-34255.

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Decentralized production systems in supply chains / networks makes them more profitable and agile than traditional enterprises with centralized production systems. However, this decentralization makes supply chains / networks more vulnerable respect to uncertainties which are unavoidable. Today’s supply chains / networks producing and supplying their products to markets are characterized by uncertain demands (called demand-side uncertainty) and uncertainties associated with the performances of their constituent production facilities (called supply-side uncertainty). Supply-side uncertainty is due to the fact that there is not any perfect production system. Sparse literature of supply-side uncertainty management in supply chains / networks is only restricted to supply chains / networks with single-echelon supply processes. However most of the real case supply chains / networks have longer production processes involving suppliers of suppliers, suppliers, component manufacturers, assemblers, etc. In this paper we fill this gap of the literature by considering a supply chain/network with multi-echelon supply process including unreliable production facilities working in markets with uncertain demands. We show that in such a complex production process in addition to investigating the local effects of the uncertainties in the performances of their corresponding facilities, it is necessary to consider their global and cumulative effect on the performance of the entire supply chain/networks by following the propagation of these uncertainties in the flow of the material and product. Not only we introduce and describe the salient features of uncertainty propagation phenomenon in supply chains/networks, but also we demonstrate its quantification approach. Finally we propose mathematical models and solution approaches that can provide robust production plans for the supply chain/network that are protected against all demand and supply side uncertainties and their propagated effects. Performances of the proposed models and solution approaches are tested with test problems and a real case problem from automotive industry.
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Jödicke, Ralph, Uwe Jungnickel, and Andreas Müller. "Lie Group Modeling of Nonlinear Helical Beam Elements." In ASME 2014 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/detc2014-34355.

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A viscoelastic beam model is presented based on SE(3) group theory. We discretize a rod with beams between finite frames on the rod and regard the configurations of these frames as elements of the SE(3) Lie group. Two subsequent frames are connected by a beam. The curvatures and strains are assumed to be constant on the trajectory between them. If the deflection curve of the beam is modeled as a helix, the resulting beam model is geometrical exact for large bending deformations. The stiffness matrices of the discrete beam elements result from the potential extensional and shearing energy as well as from the potential bending and torsion energy. The benefit of this SE(3) modeling for translational elastic coordinates and for translational forces in comparison to an SO(3) × ℝ3 variant is demonstrated.
8

Jung, Sangjin, Timothy W. Simpson, and Oyku Asikoglu. "Using Interfaces to Drive Module Definition: Investigating the Impact of a New Design Dependency Measure." In ASME 2014 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/detc2014-34555.

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Structural representations for interfaces between modules and components in a product vary widely in the literature. After reviewing several structural approaches to interface definition, a new weighted design dependency measure is described. The new representation takes into account both six different types of interfaces as well as their relative strength and frequency within a product architecture. The resulting design dependency measure provides a means for designers to quantify the change resistance in a product. In this paper, we investigate the use of this new design dependency measure to drive module identification. Specifically, we compare the resulting modules obtained by optimizing Design Structure Matrices (DSMs) using standard 0-1 representations of the interfaces to those obtained using the new design dependency measure. The results indicate that the weighted design dependency measure leads to more a logical definition of modules that maximizes within module dependencies and minimizes interactions between modules.
9

Ma, Jungmok, and Harrison M. Kim. "Predictive Usage Mining for Sustainability of Complex Systems Design." In ASME 2014 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/detc2014-34755.

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A new perspective of dynamic LCA (life cycle assessment) is proposed with the predictive usage mining for sustainability (PUMS) algorithm. By defining usage patterns as trend, seasonality, and level from a time series of usage information, predictive LCA can be conducted in a real time horizon. Large-scale sensor data of product operation is analyzed in order to mine usage patterns and build a usage model for LCA. The PUMS algorithm consists of handling missing and abnormal values, seasonal period analysis, segmentation analysis, time series analysis, and predictive LCA. A newly developed segmentation algorithm can distinguish low activity periods and help to capture patterns more clearly. Furthermore, a predictive LCA method is formulated using a time series usage model. Finally, generated data is used to do predictive LCA of agricultural machinery as a case study.
10

Aliende Urrutia, Usue, Philip Webb, and Mark Summers. "Analysis of Design for X Methodologies for Complex Assembly Processes: A Literature Review." In ASME 2014 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/detc2014-34955.

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Historically, products have been developed following the “we design it, you build it” approach. Design and production belonged to two independent entities, with no feedback from downstream activities to upstream activities. In order to avoid redesign costs caused by the lack of feedback, pioneer organisations began to apply methodologies such as ‘Design for Assembly’ or ‘Design for Manufacture’ on a daily basis. Over the years, further research has been carried out to refine these generic methodologies adding previously unconsidered perspectives, such as quality, reliability, environmental, etc. which evolved into a concept called ‘Design-for-X’ (DfX). However, existing methodologies have largely focused on simply reducing product’s structural costs, without taking into consideration other important aspects of more complex assembly processes common in the aerospace industry. The complex assembly process that this paper focuses on is the systems’ installation process within the aerospace business. The installation of fuel, electrical and other systems must follow strict aerospace regulations, intra-organisational design rules, safety policies and many more restrictions, which are not considered as key factors in current methodologies. In this paper, we endeavour to provide an extensive analysis of existing DfX methodologies and support our conclusion that there is an opportunity to develop a new methodology which will ease the aerospace systems’ installation process for the shop-floor operator.

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