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1
Costa, Eduardo Castro da, João Restle, Fabiano Nunes Vaz, Dari Celetino Alves Filho, Regis Augusto L. Carvalho Bernardes, and Fernando Kuss. "Características da Carcaça de Novilhos Red Angus Superprecoces Abatidos com Diferentes Pesos." Revista Brasileira de Zootecnia 31, no. 1 (February 2002): 119–28. http://dx.doi.org/10.1590/s1516-35982002000100014.
Abstract:
Foram avaliadas as características quantitativas da carcaça de novilhos Red Angus com idade média inicial de 8 meses e 189 kg, confinados durante 114, 144, 173 e 213 dias até os respectivos pesos de abate (PA) de 340, 370, 400 ou 430 kg, com idade de 12, 13, 14 e 15 meses. A dieta alimentar continha uma relação volumoso:concentrado de 56:44, contendo 13,13% de proteína bruta e 2,7 Mcal de energia digestível/kg MS. O corte serrote, embora tenha aumentado linearmente em peso (91,73; 103,26; 106,20 e 116,66 kg) frente ao aumento do peso de abate, decresceu linearmente quando expresso em relação ao peso de carcaça fria (50,55; 50,79; 50,16; e 48,86%). A porcentagem do corte costilhar foi a que sofreu maior incremento (23,36; 25,40; 28,50; e 35%) com o aumento do peso de abate, acompanhando o aumento na deposição de gordura de cobertura (3,91; 6,16; 6,16; e 9,58 mm). A área do músculo Longissimus dorsi (ALD) aumentou linearmente frente ao aumento do peso de abate (ALD = 27,48 + 0,083PA), enquanto a ALD/100 kg de carcaça fria decresceu linearmente (ALD/100 kg carcaça = 45,14 - 0,0425PA). Foi estimado, por intermédio da equação de regressão, que a espessura de gordura mínima exigida pelos frigoríficos (3 mm) teria sido alcançada com 327 kg de peso. Considerando o peso de carcaça mínimo de 180 kg, este seria atingido com um peso de abate de 337 kg. Utilizando novilhos da raça Red Angus para produção do superprecoce, o peso de abate não deve ser superior a 400 kg, para não exceder os 6 mm de gordura de cobertura, evitando o recorte do excesso.
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Costa, Eduardo Castro da, João Restle, Leonir Luiz Pascoal, Fabiano Nunes Vaz, Dari Celestino Alves Filho, and Miguelangelo Ziegler Arboitte. "Desempenho de Novilhos Red Angus Superprecoces, Confinados e Abatidos com Diferentes Pesos." Revista Brasileira de Zootecnia 31, no. 1 (February 2002): 129–38. http://dx.doi.org/10.1590/s1516-35982002000100015.
Abstract:
Foi avaliado o desempenho em confinamento de machos Red Angus confinados a partir dos oito meses de idade, quando apresentavam peso vivo médio de 189 kg, até atingirem os seguintes pesos pré-determinados (PA): 340, 370, 400 e 430 kg. O número de dias necessários para atingir os respectivos pesos foram de 114, 144, 168 e 209 dias, com 12, 13, 14 e 15 meses de idade. Os animais foram alimentados com uma dieta contendo 13,13% de proteína bruta e relação volumoso (silagem de milho):concentrado de 56:44. O ganho de peso médio diário foi de 1,32; 1,27; 1,23; e 1,15 kg respectivamente. O consumo médio diário de matéria seca (CMS), expresso em kg/dia/animal e por peso metabólico, não apresentou relação significativa com o peso de abate. Quando o CMS foi expresso por 100 kg de peso vivo, houve queda linear (CMS/100 kg PV= 3,599 - 0,003152PA) em relação ao aumento do peso de abate. O estado corporal melhorou linearmente com o aumento do peso de abate (ECF= 0,159 + 0,0103PA), enquanto a conversão alimentar piorou (CAMS= 1,585 + 0,01019PA), porém a mesma pode ser considerada muito boa, sendo, respectivamente, de 5,09; 5,35; 5,55; e 6,04 kg de MS/kg de ganho de peso. Foi estimado, por intermédio da equação de regressão, que, para atender o peso de carcaça e a gordura de cobertura mínimos exigidos, o peso de abate deveria ser de 337 e 327 kg, respectivamente.
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Petelytska, L., F. Bonomi, C. Cannistrà, E. Fiorentini, S. Peretti, S. Torracchi, P. Bernardini, et al. "POS1275 THE HETEROGENEITY OF DEFINING SEVERITY, PROGRESSION AND OUTCOMES IN SYSTEMIC SCLEROSIS-ASSOCIATED INTERSTITIAL LUNG DISEASE: RESULTS FROM A SYSTEMATIC LITERATURE REVIEW." Annals of the Rheumatic Diseases 82, Suppl 1 (May 30, 2023): 982.2–983. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2027.
Abstract:
BackgroundThe course of systemic sclerosis associated interstitial lung disease (SSc-ILD) is highly variable. The SSc-ILD progression (SILPRO) project aims at developing a disease specific model to define SSc-ILD progression predicting long-term, severe SSc-ILD. The evaluation of currently used definitions of severity, progression and outcomes recorded in SSc-ILD represents the highly needed first step to achieve this aim.ObjectivesTo identify definitions of progression, severity and outcomes related to SSc-ILD in the literature.MethodsA systematic literature review was conducted according to PRISMA guidelines in Medline, EMBASE and the Cochrane Library up to 31/12/2021. Eligible papers included > 10 adult SSc patients, with ILD as primary target (at least one of population, exposure, outcome). Original papers in English were considered, while papers related to secondary lung involvement, ILD onset as an outcome or reviews were excluded. Two reviewers independently identified eligible studies and extracted data, including the abovementioned definitions used.ResultsWe identified 299/8444 eligible papers, mostly reporting results of retrospective cohort studies (n=126, 42%), prospective cohort studies (n=120, 40%) and randomized clinical trials (n=24, 8%).A definition of SSc-ILD severity was included in 138 (46%) papers: it was based on high-resolution computed tomography (HRCT) data in 72 (52%) studies, on forced vital capacity (FVC) changes in 29 (21%), on combined FVC and carbon monoxide diffusing capacity (DLCO) changes in 14 (10%), on DLCO changes in 11 (8%). After combining some similar categories, 42 distinct definitions of SSc-ILD severity were identified (Figure 1 shows the most used).Figure 1.Most commonly used definitions of SSc-ILD severity (n papers).Sixty-one of 169 studies (36%) provided a definition of SSc-ILD “progression” referred to combined DLCO and FVC changes, 49 (29%) to FVC changes, 23 (14%) to DLCO changes, 18 (11%) to ILD extent on HRCT, 6 (4%) to combination of pulmonary function test (PFT), clinical signs and HRCT data, 5 (3%) to vital capacity decline, 5 (3%) to combination of PFT and HRCT data and 2 (1%) to other aspects (Table 1).Table 1.Most frequently used definitions of SSc-ILD progressionSSc mixed cohortsSSc-ILD cohortsTime, months(n papers)n patients (n papers)n ILD patients (n papers)n progressors(n papers)Time, months(n papers)n patients (n papers)n progressors (n papers)decline FVC>10%12 (8)24 (3)36 (3)>60 (2)Unk (3)3347 (17)1779 (16)605 (17)6 (3)12 (3)24 (4)>60 (4)1544 (14)263 (13)decline FVC>5%Unk (1)138 (1)100 (1)49 (1)12 (2)24 (1)Unk (1)836 (4)179 (3)decline FVC>3.3%----12 (2)Unk (1)734 (2)349 (2)decline DLCO>15%12 (2)24 (1)60 (2)568 (5)445 (5)135 (5)6 (2)12 (2)36 (1)60 (2)505 (7)168 (7)decline DLCO>10%12 (2)55 (1)>60 (1)Unk (2)340 (5)112 (2)86 (5)24 (1)14 (1)9 (1)decline FVC>10% or DLCO>15%6 (1)12 (6)24 (2)>36 (4)>60 (1)Unk (6)6170 (17)2327 (13)1144 (14)12 (8)24 (4)36 (1)>60 (3)Unk (8)1516 (20)449 (16)decline FVC >10% or DLCO>10%6 (1)12 (2)>36 (4)60 (1)531336181 (8)24 (1)36 (2)>36 (2)472 (5)47 (4)decline FVC≥10% or DLCO≥15% or ILD extent increase>20%12 (1)36 (1)24 (1)12 (1)56 (1)58 (1)12 (1)increased ILD extent>10%12 (2)347 (2)213 (2)6 (2)24 (2)145 (2)5 (2)increased ILD extent>20%---24 (1)Unk (1)22 (2)8 (2)increased ILD extent12 (1)37 (1)62 (1)1024 (3)440 (3)99 (3)12 (1)75 (1)34 (1)Among all articles, 47 outcomes related to SSc-ILD were identified from 153 papers. The most frequent outcomes represented hard endpoints, such as mortality (131 papers), end stage lung disease (8 papers), hospitalization (6 papers) and malignancies (4 papers).ConclusionThe studies reporting a definition of SSc-ILD “progression”, “severity” and “outcome” show a large heterogeneity. These results emphasize the need for developing a standardized, consensus definition of severe SSc-ILD, to link a disease specific definition of progression as a surrogate outcome for clinical trials and clinical practice.Acknowledgementson behalf of the SILPRO project investigators.Disclosure of InterestsLiubov Petelytska Grant/research support from: received research grant from Swiss National Research Foundation/Scholars at risk, Francesco Bonomi: None declared, Carlo Cannistrà: None declared, Elisa Fiorentini: None declared, Silvia Peretti: None declared, SARA Torracchi: None declared, Pamela Bernardini: None declared, Carmela Coccia: None declared, Riccardo De Luca: None declared, Alessio Economou: None declared, Juela Levani: None declared, Marco Matucci-Cerinic Speakers bureau: Actelion, Janssen, Inventiva, Bayer, Biogen, Boehringer, CSL Behring, Corbus, Galapagos, Mitsubishi, Samsung, Regeneron, Acceleron, MSD, Chemomab, Lilly, Pfizer, Roche., Consultant of: Actelion, Janssen, Inventiva, Bayer, Biogen, Boehringer, CSL Behring, Corbus, Galapagos, Mitsubishi, Samsung, Regeneron, Acceleron, MSD, Chemomab, Lilly, Pfizer, Roche., Oliver Distler Speakers bureau: 4P-Pharma, Abbvie, Acceleron, Alcimed, Altavant, Amgen, AnaMar, Arxx, AstraZeneca, Blade, Bayer, Boehringer Ingelheim, Corbus, CSL Behring, Galderma, Galapagos, Glenmark, Gossamer, iQvia, Kymera, Lupin, Medscape, Merck, Miltenyi Biotec, Mitsubishi Tanabe; Novartis, Prometheus, Redxpharna, Roivant and Topadur in the area of potential treatments of scleroderma and its complications, Consultant of: 4P-Pharma, Abbvie, Acceleron, Alcimed, Altavant, Amgen, AnaMar, Arxx, AstraZeneca, Blade, Bayer, Boehringer Ingelheim, Corbus, CSL Behring, Galderma, Galapagos, Glenmark, Gossamer, iQvia, Kymera, Lupin, Medscape, Merck, Miltenyi Biotec, Mitsubishi Tanabe; Novartis, Prometheus, Redxpharna, Roivant and Topadur in the area of potential treatments of scleroderma and its complications, Grant/research support from: 4P-Pharma, Abbvie, Acceleron, Alcimed, Altavant, Amgen, AnaMar, Arxx, AstraZeneca, Blade, Bayer, Boehringer Ingelheim, Corbus, CSL Behring, Galderma, Galapagos, Glenmark, Gossamer, iQvia, Kymera, Lupin, Medscape, Merck, Miltenyi Biotec, Mitsubishi Tanabe; Novartis, Prometheus, Redxpharna, Roivant and Topadur in the area of potential treatments of scleroderma and its complications. Research grants: Kymera, Mitsubishi Tanabe, Cosimo Bruni Speakers bureau: Eli-Lilly, Consultant of: Boehringer Ingelheim, Grant/research support from: Gruppo Italiano Lotta alla Sclerodermia (GILS), European Scleroderma Trials and Research Group (EUSTAR), Foundation for research in Rheumatology (FOREUM), Scleroderma Clinical Trials Consortium (SCTC). Educational grants from AbbVie.
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Tsyrenov, Chingis Ts. "Ruling Clans of the Eastern Jin Era (317–420 AD) and Early Chinese Buddhism." Humanitarian Vector 14, no. 6 (2019): 150–55. http://dx.doi.org/10.21209/1996-7853-2019-14-6-150-155.
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Wiendels, NJ, A. Knuistingh Neven, FR Rosendaal, P. Spinhoven, FG Zitman, WJJ Assendelft, and MD Ferrari. "Chronic Frequent Headache in the General Population: Prevalence and Associated Factors." Cephalalgia 26, no. 12 (December 2006): 1434–42. http://dx.doi.org/10.1111/j.1468-2982.2006.01210.x.
Abstract:
We studied the prevalence and short-term natural course of chronic frequent headache (CFH) in the general population and identified risk factors. In the Netherlands everyone is registered at a single general practice. We sent questionnaires to all persons ( n = 21 440) aged 25-55 years, registered at 16 general practices. We compared the characteristics of 177 participants with CFH (>14 headache days/month for >3 months) with 141 participants with infrequent headache (1-4 days/month) and 526 without headache (<1 day/month). The prevalence of CFH was 3.7% [95% confidence interval (CI) 3.4, 4.0]. In 5 months, 12% showed a clinically relevant decrease to <7 days/month. In both headache groups 70% were women vs. 41% in the group without headache. Compared with the group with infrequent headache, the CFH group had more subjects with low educational level [35% vs. 11%; odds ratio (OR) 4.3, 95% CI 2.3, 7.8], medication overuse (62% vs. 3%; OR 38.4, 95% CI 13.8, 106.9), sleeping problems (44% vs. 8%; OR 8.1, 95% CI 3.6, 18.1), a history of head/neck trauma (36% vs. 14%; OR 4.0, 95% CI 2.2, 7.1), high scores on the General Health Questionnaire (62% vs. 34%; OR 2.7, 95% CI 1.3, 3.6) and more smokers (45% vs. 19%; OR 3.1, 95% CI 1.9, 5.3). We conclude that headache frequency fluctuates. CFH is common and associated with overuse of analgesics, psychopathology, smoking, sleeping problems, a history of head/neck trauma and low educational level. Female sex is a risk factor for headache, not for chronification of headache.
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Fernández-Ontiveros, J. A., K. M. Dasyra, E. Hatziminaoglou, M. A. Malkan, M. Pereira-Santaella, M. Papachristou, L. Spinoglio, et al. "A CO molecular gas wind 340 pc away from the Seyfert 2 nucleus in ESO 420-G13 probes an elusive radio jet." Astronomy & Astrophysics 633 (January 2020): A127. http://dx.doi.org/10.1051/0004-6361/201936552.
Abstract:
A prominent jet-driven outflow of CO(2–1) molecular gas is found along the kinematic minor axis of the Seyfert 2 galaxy ESO 420-G13, at a distance of 340–600 pc from the nucleus. The wind morphology resembles the characteristic funnel shape, formed by a highly collimated filamentary emission at the base, and likely traces the jet propagation through a tenuous medium, until a bifurcation point at 440 pc. Here the jet hits a dense molecular core and shatters, dispersing the molecular gas into several clumps and filaments within the expansion cone. We also trace the jet in ionised gas within the inner ≲340 pc using the [Ne II]12.8 μm line emission, where the molecular gas follows a circular rotation pattern. The wind outflow carries a mass of ∼8 × 106 M⊙ at an average wind projected speed of ∼160 km s−1, which implies a mass outflow rate of ∼14 M⊙ yr−1. Based on the structure of the outflow and the budget of energy and momentum, we discard radiation pressure from the active nucleus, star formation, and supernovae as possible launching mechanisms. ESO 420-G13 is the second case after NGC 1377 where a previously unknown jet is revealed through its interaction with the interstellar medium, suggesting that unknown jets in feeble radio nuclei might be more common than expected. Two possible jet-cloud configurations are discussed to explain an outflow at this distance from the AGN. The outflowing gas will likely not escape, thus a delay in the star formation rather than quenching is expected from this interaction, while the feedback effect would be confined within the central few hundred parsecs of the galaxy.
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Restle, João, Paulo Santana Pacheco, Eduardo Castro da Costa, Aline Kellermann de Freitas, Fabiano Nunes Vaz, Ivan Luiz Brondani, and Juliano José de Resende Fernandes. "Apreciação econômica da terminação em confinamento de novilhos Red Angus superjovens abatidos com diferentes pesos." Revista Brasileira de Zootecnia 36, no. 4 (August 2007): 978–86. http://dx.doi.org/10.1590/s1516-35982007000400030.
Abstract:
Objetivou-se com este estudo avaliar economicamente a terminação em confinamento de novilhos Red Angus superjovens alimentados até atingirem os pesos de abate pretendidos de 340, 370, 400 e 430 kg (pesos reais obtidos: 340, 373, 401 e 434 kg). O número de dias necessários para atingir os respectivos pesos foi de 114, 144, 168 e 209 dias aos 12, 13, 14 e 15 meses de idade. Os animais foram alimentados com dieta contendo 13,26% de PB e relação volumoso (silagem de milho):concentrado de 56,21:43,79 na MS. Na formação e condução da lavoura para produção de volumoso, as operações mais representativas do custo total/ha foram, em ordem decrescente, adubação de plantio (21,21%), adubação de cobertura (12,86%), sementes (11,40%) e controle de plantas daninhas (5,78%) e de pragas (4,52%). A alimentação (volumoso mais concentrado) foi o componente de custo mais representativo (média de 77,2%) se desconsiderado o custo de compra do animal. Da alimentação, o concentrado foi o componente mais oneroso (58,3%). O custo/kg de ganho de peso incrementou linearmente com o aumento no peso de abate, sendo de 1,94; 2,06; 2,15 e 2,34 R$/kg, respectivamente, para os pesos de abate de 340, 373, 401 e 434 kg. O incremento no peso de abate de 340 para 434 kg reduziu a lucratividade da terminação em confinamento de novilhos Red Angus superjovens.
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Raya-Santos, C., J. Rosas, M. Marco, A. Pons-Bas, R. Gallego-Campuzano, J. C. Cortés-Quiroz, M. Shalabi, et al. "POS0168 IMPACT OF THE HYDROXYCHLOROQUINE LEVEL ON THE ECG QT INTERVAL IN PATIENTS WITH SYSTEMIC RHEUMATIC AUTOIMMUNE DISEASES: A REAL-LIFE STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (May 30, 2023): 307.2–307. http://dx.doi.org/10.1136/annrheumdis-2023-eular.6199.
Abstract:
Background:NIL.ObjectivesTo analyze the impact of the serum level of HCQ on the QTc interval, in patients with rheumatic systemic autoimmune diseases (RSAD), treated with this drug a long time.MethodsRetrospective study, among patients with RSAD, treated with HCQ > 1 year, dose 200-400 mg/day (cases). Serum HCQ level was measured and the QTc interval of the ECG. Patients with EASR not treated with HCQ were included as a control group for QTc: weight, current treatment, and ECG was performed to obtain QTc.In patients with RSAD, the following was collected: 1) Epidemiological data of the patient 2) RSAD: diagnosis, year of diagnosis, time of evolution of the disease, own clinical and autoimmunity data, treatment and dose 3) HCQ: time in treatment, toxicity, symptoms and serum level. 4) ECG; QTc and heart rate (HR).Results142 patients treated with HCQ for a mean of 8.3 (SD: 6.4) years, at a mean dose of 245 mcg/L (83.8), and 3.7 (1.3) mg/kg/day, are included. 129 (91%) are women, mean age: 57 (14.5) years, weight: 66 (15) kg. Diagnosis distribution: SLE: 72 (50%) patients, RA: 37 (26%), Sjögren syndrome: 18 (13%), palindromic rheumatism: 4 (3%), psoriatic arthritis: 3 (2%), antiphospholipid syndrome: 2 (1%) and other collagen diseases: 2 (1%) patients.Mean HCQ serum level: 185.6 mcg/L (124): 25 (28%) with a level <100 mcg/L (mean: 58 [28.5] mcg/L) and 117 (72%) >100 mcg/L (mean: 224 mcg/L [116]). On ECG, the mean HR: 72 bpm (11) and the mean QTc interval: 419 (33) ms, being prolonged (>440 ms) in 39 (27%) patients (range: 441-510 ms).Ten (7%) patients reported symptoms: palpitations: 7 (70%), dizziness in 2 (20%) and 1 (10%) patient an isolated pseudosyncopal picture (QTc: 441 ms); 58 (41%) patients were receiving treatment with a drug related to the risk of QTc prolongation: Possible (P: authorized doses, no risk of TdP): 8 (14%) patient, Conditional (C: risk in certain circumstances: excessive dose, interactions): 44 (76%), Defined (D: risk of TdP when used in licensed indications): 1 (2%). When comparing the mean QTc result of the EASR group treated with HCQ and the control group without HCQ (n: 32), no differences were detected (419.4 [33] vs 436 [51], p=0.072).Among patients with HCQ level >100 mcg/L (n: 117/82%) vs <100 mcg/L (n: 25/18%), the mean daily dose of HCQ received (250 mg [87.7] vs 220 mg [57.7], p=0.33) and the one adjusted to the weight of the patient in both is higher (3.76 [1.4] mg/kg vs 3.18 [1] mg/kg, p=0.016). No relationship was observed between the HCQ level and the QTc result.The 39 (27%) patients with QTc >440 ms vs the 103 (73%) with QTc ≤ 440 ms were significantly older (61 [14] years vs 55 [14] years, p=0.007) and higher heart rate (75 [12] bpm vs 71 [10.6] bpm, p=0.016). No differences were detected between QTc result and HCQ dose or level.ConclusionIn patients with EASR treated with maintenance doses of HCQ: 1) The serum level of HCQ is not related to prolongation of the QTc interval of the ECG. 2) QTc is significantly related to age and heart rate. 3) 40% of patients with prolonged HCQ treatment also receive other common drugs that can influence the QTc, however, it does not seem to cause symptoms of interest. 4) The EASR per se does not affect the QTc result.Table 1.Characteristics of the patients with according to the result of the QTc and the level of HCQQTc >440 ms N: 39 (27%)QTc<440 ms N: 103 (73%)pAge, mean (SD)61 (14.4)55 (14)0.007Female, n (%)36 (92)93 (90)0.85QTc, mean (SD)455.7 (14.8)405 (28)0.0001Heart rate, mean (SD)75 (12)71 (10.6)0.016Weight, mean (SD)70.4 (15.4)68.5 (15.2)0.61HCQ;Dose mcg/L, mean (SD)246.5 (88.4)244.6 (82.5)0.15Mg/kg HCQ, mean (SD)3.61 (1.44)3.68 (1.3)0.79Years in HCQ, mean (SD)8.7 (6.3)8.2 (6.5)0.48HCQ serum level mcg/L, mean (SD)192.5 (131.5)182.3 (121.5)0.67Range10-60310-658-HCQ >100 mcg/L N: 117 (82%)HCQ<100 mcg/L N: 25 (18%)pHCQ serum level, mean (SD)224.1 (116)58 (28.4)0.0001QTc, mean (SD)417 (34)427.5 (28)0.10Dose mcg/L, mean (SD)250.4 (87.7)220 (57.7)0.033Mg/kg HCQ, mean (SD)3.76 (1.4)3.18 (1.0)0.016Years in HCQ, mean (SD)8.03 (6.4)9.81 (6.4)0.20Weight, mean (SD)68.4 (15)72 (16)0.30AcknowledgementsThe study was supported by a research grant from the Marina Baixa Association for Research in Rheumatology (AIRE-MB).Disclosure of InterestsNone Declared.
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Fujii, A. M., S. F. Vatner, J. Serur, A. Als, and I. Mirsky. "Mechanical and inotropic reserve in conscious dogs with left ventricular hypertrophy." American Journal of Physiology-Heart and Circulatory Physiology 251, no. 4 (October 1, 1986): H815—H823. http://dx.doi.org/10.1152/ajpheart.1986.251.4.h815.
Abstract:
We studied the left ventricular (LV) responses to infusions of norepinephrine and prenalterol, a specific beta 1-adrenergic receptor agonist, in conscious, chronically instrumented adult dogs with severe LV hypertrophy. The goal of this study was to determine the extent of compensation induced by LV hypertrophy in an animal model in which the pressure overload was gradually increased, as occurs in human pathological states. One to 2 yr after banding the ascending aorta of puppies, six dogs with severe LV hypertrophy (LV free-wall weight-to-body weight ratio 7.0 +/- 0.4 g/kg), and nine sham-operated littermates (LV free-wall weight-to-body weight ratio 4.0 +/- 0.2 g/kg) were studied. The dogs were instrumented with ultrasonic dimension crystals (to measure LV short-axis diameter and wall thickness), miniature LV pressure transducers, and LV and aortic catheters. In the control dogs norepinephrine (0.4 micrograms X kg-1 X min-1) increased LV systolic/diastolic pressure from 121 +/- 2/9 +/- 1 to 177 +/- 9/20 +/- 2 mmHg, mean arterial pressure from 97 +/- 2 to 143 +/- 9 mmHg, LV dP/dt from 3,363 +/- 123 to 5,174 +/- 343 mmHg/s, and mean systolic wall stress from 194 +/- 14 to 299 +/- 22 g/cm2, while mean velocity of circumferential fiber shortening (Vcf), (dD/dt/D)max, and heart rate did not change from base line. In dogs with LV hypertrophy norepinephrine increased LV pressure from 224 +/- 16/11 +/- 1 to 305 +/- 22/19 +/- 1 mmHg, mean arterial pressure from 90 +/- 2 to 132 +/- 4 mmHg, LV dP/dt from 3,246 +/- 156 to 5,619 +/- 345 mmHg/s, and mean systolic wall stress from 224 +/- 11 to 307 +/- 24 g/cm2.(ABSTRACT TRUNCATED AT 250 WORDS)
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Jackson, Carlton D., and Boon-Nam Blackwell. "Subchronic Studies of Tripelennamine in Fischer 344 Rats." Journal of the American College of Toxicology 10, no. 5 (September 1991): 493–502. http://dx.doi.org/10.3109/10915819109078646.
Abstract:
The purpose of this study was to determine the subchronic toxicity of the antihistamine tripelennamine and to allow selection of appropriate doses for chronic studies. Male and female Fischer 344 rats were administered tripelennamine hydrochloride in the feed at dose levels of 0, 300, 600, 1200, 2400, and 6000 ppm (as the free amine) for 14 days or at dose levels of 0, 150, 300, 600, 1200, and 2400 ppm for 90 days. In the 14-day study, all of the animals in the 6000 ppm groups died. All others survived until killed. Final body weights of treated groups were reduced from 3% to 25%. Cytoplasmic vacuolization of the liver was observed. In the 90-day study, a dose-dependent reduction in body weight gain was produced by tripelennamine, with a 10% reduction in final body weight occurring between 300 and 600 ppm. Reductions in various organ weights were found to be correlated with reduced final body weights. Tripelennamine produced cytoplasmic vacuolization or fatty change in the liver, cytomegaly and granular basophilic cytoplasm in the parotid salivary gland, and vacuolar degeneration of the bronchial epithelium of the lung. Based on the results of this study, it was determined that 400 ppm tripelennamine administered ad libitum in the feed to both male and female Fischer 344 rats would be an appropriate highest dose for a 2-year carcinogenicity study.
11
Grider, Jay S. "Patient Selection and Outcomes Using a LowDose Intrathecal Opioid Trialing Method for Chronic Nonmalignant Pain." Pain Physician 4;14, no. 4;7 (July 14, 2011): 343–51. http://dx.doi.org/10.36076/ppj.2011/14/343.
Abstract:
Background: Various methods exist for trialing patients for intrathecal drug delivery. Currently no standards exist regarding “best practices” for trialing techniques. Objectives: The specific aim of the current study is to report results of patients trialed using a low-dose intrathecal morphine technique in the treatment of chronic noncancer pain. Setting: academic pain medicine practice Study Design: Retrospective Review Method: Visual analog pain scores (VAS) were obtained at the initial visit, after a 6 week opioid-free interval prior to trial, at intrathecal doses of 25, 50, 100, 200 and 400 µg of intrathecal morphine during the trial, at one month post-implant, and current VAS. Additionally, intrathecal opioid doses at implant and current state are reported. Results: VAS scores at the initial visit and after 6 weeks of opioid cessation were identical. There was a significant improvement in VAS after the trial, which was sustained over the course of therapy. Additionally, the use of the protocol described in this article suggests that the doseresponse relationship following opioid cessation is in the 50-400 µg/d range for intrathecal morphine and that tolerance may be reversed during the 6 week opioid-free period. Limitations: Small trialing study Conclusions: Opioid taper and a 6 week opioid-free period may 1) improve long-term analgesia versus a combination of oral/ intrathecal drug delivery system therapy 2) it may be possible to maintain analgesia at microgram doses and 3) opioid tolerance may be reversible in 6 weeks. Further it appears that a dose response relationship for effective analgesia may be less than 400 µg of intrathecal morphine. Key Words: Intrathecal opioids, intrathecal drug delivery, oral opioid therapy, chronic noncancer pain
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AUGUSTO, MARCELO SOARES, SAMUEL SILVA, JORGE LUIZ XAVIER LINS CUNHA, ANA BEATRIZ DE ALMEIDA MOURA, ANA CAROLINE DE ALMEIDA MOURA, and ALLAN HEMERSON DE MOURA. "CRESCIMENTO E RENDIMENTO AGRÍCOLA DA CULTURA DO MILHO SOB DIFERENTES DISPONIBILIDADES HÍDRICAS." IRRIGA 26, no. 2 (June 30, 2021): 328–42. http://dx.doi.org/10.15809/irriga.2021v26n2p328-342.
Abstract:
CRESCIMENTO E RENDIMENTO AGRÍCOLA DA CULTURA DO MILHO SOB DIFERENTES DISPONIBILIDADES HÍDRICAS MARCELO AUGUSTO DA SILVA SOARES1; SAMUEL SILVA2; JORGE LUIZ XAVIER LINS CUNHA3; ANA BEATRIZ DE ALMEIDA MOURA4; ANA CAROLINE DE ALMEIDA MOURA5 E ALLAN HEMERSON DE MOURA6 1 Doutorando em Produção Vegetal, Departamento de Tecnologia da Produção, Universidade Federal de Alagoas (UFAL), Av. Lourival Melo Mota, S/N, Tabuleiro do Martins, 57072-970, Maceió, Alagoas, Brasil, marcelocico_@hotmail.com. 2 Professor do Instituto Federal de Alagoas (IFAL), Campus Piranhas, Av. Sergipe, 1477, 57460-000, Piranhas, Alagoas, Brasil, samuel.silva@ifal.edu.br 3 Professor do Centro de Engenharia e Ciências Agrárias (CECA), Universidade Federal de Alagoas (UFAL), Av. Lourival Melo Mota, S/N, Tabuleiro do Martins, 57072-970, Maceió, Alagoas, Brasil, jorge.cunha.xavier@gmail.com 4 Graduando em Zootecnia pelo Centro de Engenharia e Ciências Agrárias (CECA), Universidade Federal de Alagoas (UFAL), Av. Lourival Melo Mota, S/N, Tabuleiro do Martins, 57072-970, Maceió, Alagoas, Brasil, anabeatrizamoura@gmail.com 5 Graduando em Agronomia pelo Centro de Engenharia e Ciências Agrárias (CECA), Universidade Federal de Alagoas (UFAL), Av. Lourival Melo Mota, S/N, Tabuleiro do Martins, 57072-970, Maceió, Alagoas, Brasil, anacarolineamoura@outlook.com 6 Mestrando em Produção Vegetal, Departamento de Tecnologia da Produção, Universidade Federal de Alagoas (UFAL), Av. Lourival Melo Mota, S/N, Tabuleiro do Martins, 57072-970, Maceió, Alagoas, Brasil, allanmoura.h@gmail.com. 1 RESUMO O objetivo deste trabalho foi avaliar o efeito dos déficits e excessos hídricos no crescimento e rendimento agrícola do milho em diferentes épocas de cultivo na região de Rio Largo, AL. Para isso, foi conduzido um experimento no Campus de Engenharia e Ciências Agrárias da Universidade Federal de Alagoas. O delineamento foi em blocos casualizados, com quatro tratamentos e cinco repetições (E1= 28/05/14, E2-11/06/14, E3-25/06/14 e E4- 23/07/14). A primeira época de plantio foi a que apresentou maior altura do dossel (2,25 m), índice de área foliar (4,0 m2 m-2) e rendimento agrícola (8,03 t ha-1). A E4 apresentou a menor altura do dossel (0,9 m) e a menor produtividade agrícola foi observada na E3 (5,9 t ha-1). Isso aconteceu porque com base no balanço hídrico da cultura, quando o plantio é realizado até o primeiro decêndio de junho há uma melhor distribuição da chuva o que maximiza o potencial da cultura. Palavras-chave: produtividade de grãos, precipitação pluvial, balanço hídrico SOARES, M. A. S.; SILVA, S.; CUNHA, J. L. X. L.; MOURA, A. B A.; MOURA, A. C. A.; MOURA, A. H. GROWTH AND YIELD OF MAIZE CROP UNDER DIFFERENT WATER AVAILABILITIES 2 ABSTRACT This work aimed to evaluate the effects of hydric deficits and excesses on growth and yield of corn at different times of cultivation in the region of Rio Largo, Al. For this, an experiment was conducted at the Campus of Engineering and Agricultural Sciences of the Federal University of Alagoas. The statistical design was randomized blocks, with four treatments and five replications (E1 = 28/05/14, E2-11 / 06/14, E3-25 / 06/14, and E4- 23/07/14). The first planting season was the one with the highest canopy height (2.25 m), leaf area index (4.0 m2 m-2) and agricultural yield (8.03 t ha-1). The E4 had the lowest canopy height (0.9 m) and the lowest agricultural yield was observed in the E3 (5.9 t ha-1). This happened because based on the water balance of the crop, when planting is carried out until the first ten days of June, there is a better distribution of rain, which maximizes the crop's potential. Keywords: yield of grains, rainfall, water balance
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Frymoyer, Adam, Adam L. Hersh, Mohammed H. El-Komy, Shabnam Gaskari, Felice Su, David R. Drover, and Krisa Van Meurs. "Association between Vancomycin Trough Concentration and Area under the Concentration-Time Curve in Neonates." Antimicrobial Agents and Chemotherapy 58, no. 11 (August 18, 2014): 6454–61. http://dx.doi.org/10.1128/aac.03620-14.
Abstract:
ABSTRACTNational treatment guidelines for invasive methicillin-resistantStaphylococcus aureus(MRSA) infections recommend targeting a vancomycin 24-h area under the concentration-time curve (AUC0–24)-to-MIC ratio of >400. The range of vancomycin trough concentrations that best predicts an AUC0–24of >400 in neonates is not known. This understanding would help clarify target trough concentrations in neonates when treating MRSA. A retrospective chart review from a level III neonatal intensive care unit was performed to identify neonates treated with vancomycin over a 5-year period. Vancomycin concentrations and clinical covariates were utilized to develop a one-compartment population pharmacokinetic model and examine the relationships between trough and AUC0–24in the study neonates. Monte Carlo simulations were performed to examine the effect of dose, postmenstrual age (PMA), and serum creatinine level on trough and AUC0–24achievement. A total of 1,702 vancomycin concentrations from 249 neonates were available for analysis. The median (interquartile range) PMA was 39 weeks (32 to 42 weeks) and weight was 2.9 kg (1.6 to 3.7 kg). Vancomycin clearance was predicted by weight, PMA, and serum creatinine level. At a trough of 10 mg/liter, 89% of the study neonates had an AUC0–24of >400. Monte Carlo simulations demonstrated that troughs ranging from 7 to 11 mg/liter were highly predictive of an AUC0–24of >400 across a range of PMA, serum creatinine levels, and vancomycin doses. However, a trough of ≥10 mg/liter was not readily achieved in most simulated subgroups using routine starting doses. Higher starting doses frequently resulted in troughs of >20 mg/liter. A vancomycin trough of ∼10 mg/liter is likely adequate for most neonates with invasive MRSA infections based on considerations of the AUC0–24. Due to pharmacokinetic and clinical heterogeneity in neonates, consistently achieving this target vancomycin exposure with routine starting doses is difficult. More robust clinical dosing support tools are needed to help clinicians with dose individualization.
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Ram, P. S. Nithes, Santosh Haralkar, Abhishek Gawande, and Akhil Soni. "Knowledge, attitude and preventive behaviours regarding COVID-19 infection among medical students of Solapur, Maharashtra." International Journal Of Community Medicine And Public Health 9, no. 4 (March 25, 2022): 1744. http://dx.doi.org/10.18203/2394-6040.ijcmph20220848.
Abstract:
Background: It is important for medical students to know about COVID-19 in order for them to be a well-versed future health workers. The aim of the study was to assess the knowledge, attitude, and practice regarding COVID-19 infection among medical students at government medical college in western Maharashtra. To study the knowledge, attitude and practice regarding COVID-19 infection among medical students and to find the association between KAP levels and demographic variables.Methods: An observational descriptive study with cross sectional design was conducted during July 2021 on 400 Under Graduate medical students of a Government medical college.Results: Out of 400 students 53%- female (212); 47%- male (188). Most of the students belong to Hindu religion 86.75% (347), rest Muslim 39 (9.75%), Christians 14 (3.5%). Overall, 92%, 81%, 90.5% of surveyed medical students had adequate knowledge, attitude and practice towards COVID 19 pandemic respectively.Conclusions: In our study, students exhibited good knowledge, positive attitude, and sensible practices regarding COVID-19. Such KAP studies should be conducted across other medical college and we should educate our medical students so that we can use the help of medical students for management of mild covid cases if manpower crisis occurs.
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Johnscher, Michael, Frank Tappe, Oliver Niehaus, and Rainer Pöttgen. "The equiatomic intermetallics REPtCd (RE= La, Ce, Pr, Nd, Eu) and magnetic properties of CeAuCd." Zeitschrift für Naturforschung B 70, no. 3 (March 1, 2015): 197–202. http://dx.doi.org/10.1515/znb-2014-0255.
Abstract:
AbstractThe cadmium intermetallics REPtCd (RE = La, Ce, Pr, Nd, Eu) and CeAuCd were synthesized by induction-melting of the elements in sealed niobium ampoules followed by annealing in muffle furnaces. The samples were characterized by powder X-ray diffraction. The structures of CePtCd (ZrNiAl type, $P\bar 62m,$a = 763.8(6), c = 409.1(4) pm, wR2 = 0.0195, 298 F2 values, 14 variables) and EuPtCd (TiNiSi type, Pnma, a = 741.3(2), b = 436.4(1), c = 858.0(4) pm, wR2 = 0.0385, 440 F2 values, 20 variables) were refined from single-crystal data. The REPtCd structures exhibit three-dimensional networks of corner- and edge-sharing Cd@Pt2/6Pt2/3 and Cd@Pt4/4 tetrahedra, which leave cages for the rare earth atoms. Temperature-dependent magnetic susceptibility data of CeAuCd reveal a paramagnetic to antiferromagnetic phase transition at TN = 3.7(5) K.
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Patil, Nagaraj, K. V. Jagadeesh, K. Yamini Priyanka, Annapurna Kari, and Mubashir Angolkar. "Prevalence of anemia among adolescent girls in a North Karnataka school: a cross sectional study." International Journal Of Community Medicine And Public Health 5, no. 12 (November 24, 2018): 5360. http://dx.doi.org/10.18203/2394-6040.ijcmph20184817.
Abstract:
Background: World Health Organization (WHO) has defined ‘Adolescence’ as a period between 10 and 19 years. Anemia is a condition characterized by reduction in the number of red blood cells and/or hemoglobin concentration. Adolescent girls are at increased risk of anemia due to rapid growth and developmental process. The objectives of the study were to estimate the prevalence of anemia among adolescent girls in one of the schools in North Karnataka.Methods: A cross sectional study was conducted among adolescent girls in one of the CBSE Schools of north Karnataka. In 347 adolescent girls, data collection was carried out in the month of August 2017 through hematological assessment. All the adolescent girls between grade 7 and 12 were included in the study. Statistical analysis was conducted using statistical package for social sciences (SPSS) software version 20.0.Results: Out of 347 adolescent girls enrolled more than half 196 (56.5%) were mid adolescent with a mean age of 14.34±1.8. 54 (15.6%) were showing mild thinness and 14 (4.0%) were overweight. Overall prevalence of anemia was 44.4% (n=154). Where in 35.2% (n=122) were mild anemic followed by 8.9% (n=31) moderate anemia. Among the anemic girls, 79.8% (n=123) had attained their menarche and 6.5% (n=10) were reported passing worms in stools.Conclusions: Prevalence of anemia among school adolescent girls was found to be less. Among anemic girls, majority were showing mild anemia.
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Sukendar, Irwan, Eli Mas'idah, and Raka Wisnu Prayuda. "Penerapan Green Manufacturing pada IKM Dadi Mulyo." Applied Industrial Engineering Journal 5, no. 1 (June 1, 2021): 30–34. http://dx.doi.org/10.33633/aiej.v5i1.5151.
Abstract:
AbstractIKM Dadi Mulyo produces wood sawdust waste of approximately 400kg/day which if left for days on end will accumulate more and pollute the company's environment and the surrounding environment. Green Manufacturing method is used to perform analysis to reduce waste and increase added value. The research was conducted by direct observation and interviews. The results of the analysis show that the application of green manufacturing is able to reduce waste and increase added value by 50%. So that the increase in added value has the potential to improve the welfare of employees. Keywords: Waste, Green manufacturing, Value stream mapping, Future Stream Mapping, Value Added AbstrakIKM Dadi Mulyo menghasilkan limbah serbuk gergaji kayu kurang lebih 400 kg/hari yang apabila dibiarkan berhari-hari akan menjadi semakin menumpuk, mencemari lingkungan perusahaan dan lingkungan sekitar. Metode Green Manufacturing digunakan untuk melakukan analisis guna mengurangi pemborosan dan meningkatkan nilai tambah. Penelitian dilakukan dengan observasi langsung dan wawancara. Hasil analisis menunjukkan bahwa penerapan Green Manufacturing mampu mengurangi pemborosan dan meningkatkan nilai tambah sebesar 50%. Sehingga peningkatan nilai tambah berpotensi untuk meningkatkan kesejahteraan karyawan.Kata kunci: Waste, Green manufacturing, Value stream mapping, Future Stream Mapping, Value AddedReferensi[1] I. W. Sutarman, “Pemanfaatan Limbah Industri Pengolahan Kayu Di Kota Denpasar (Studi Kasus Pada Cv Aditya),” J. PASTI, vol. 10, no. 1, pp. 15–22, 2016.[2] Bahri S., “Pemanfaatan Limbah Industri Pengolahan kayu untuk pembuatan briket arang dalam mengurangi pencemaran lingkungan di Nangroe Aceh Darussalam,” J. Mek., vol. vol.4 no.2, pp. 410–415, 2007.[3] I. N. Tika, I. G. Ayu, T. Agustiana, D. Agus, and W. Erawan, “Pengolahan Limbah Serbuk Gergaji Kayu Menjadi Bata Akustik,” pp. 585–593, 2017.[4] I. Artikel, “Jurnal SENOPATI,” pp. 50–61, 2019.[5] U. Malik, “Jurusan Fisika Fakultas Matematika dan Imu Pengetahuan Alam Universitas Riau,” vol. I, no. 2, pp. 21–26, 1994.[6] P. O. Box and S. Lind, “Proceedings of the 2008 Winter Simulation Conference S. J. Mason, R. R. Hill, L. Mönch, O. Rose, T. Jefferson, J. W. Fowler eds.,” pp. 1922–1930, 2008.[7] C. B. Joung, J. Carrell, P. Sarkar, and S. C. Feng, “Categorization of indicators for sustainable manufacturing,” Ecol. Indic., vol. 24, pp. 148–157, 2013, doi: 10.1016/j.ecolind.2012.05.030.[8] T. Stock and G. Seliger, “Opportunities of Sustainable Manufacturing in Industry 4.0,” Procedia CIRP, vol. 40, no. Icc, pp. 536–541, 2016, doi: 10.1016/j.procir.2016.01.129.[9] S. Editor, Front Matter. 2014.[10] “13 Green Manufacturing.pdf.” .[11] A. M. Deif, “A system model for green manufacturing,” J. Clean. Prod., vol. 19, no. 14, pp. 1553–1559, 2011, doi: 10.1016/j.jclepro.2011.05.022.[12] W. Widada, “Reduce The Risk of Atherosclerosis through the wet Cupping Therapy,” J. Med. Sci. Clin. Res., vol. 6, no. 11, pp. 581–586, 2018, doi: 10.18535/jmscr/v6i11.102.[13] S. Sih, W. Wijayanti, and P. D. Sukmawati, “Potensi Limbah Serat Kayu Dari Pelepah Pisang Kering Sebagai Bahan Baku Pembuatan Frame Kacamata,” pp. 340–342.[14] S. Wardani, “Pemanfaatan Limbah Batu Bara ( Fly Ash ) Untuk Stabilitas Tanah Maupun Keperluan Teknik Sipil Lainnya Dalam Manggurangi Pencemaran Lingkungan,” Pengukuhan Guru Besar Fak. Tek. Univ. Diponogoro, pp. 1–71, 2008.
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Rechnitzer, A., and A. L. Owczarek. "On three-dimensional self-avoiding walk symmetry classes." Journal of Physics A: Mathematical and General 33, no. 14 (March 31, 2000): 2685–723. http://dx.doi.org/10.1088/0305-4470/33/14/307.
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Mañas, Manuel, Luis Martínez Alonso, and Elena Medina. "Dressing methods for geometric nets: I. Conjugate nets." Journal of Physics A: Mathematical and General 33, no. 14 (March 31, 2000): 2871–94. http://dx.doi.org/10.1088/0305-4470/33/14/317.
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Draayer, J. P., A. I. Georgieva, and M. I. Ivanov. "Deformations of the bosonsp(4,R) representation and its subalgebras." Journal of Physics A: Mathematical and General 34, no. 14 (March 30, 2001): 2999–3014. http://dx.doi.org/10.1088/0305-4470/34/14/307.
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Matos-Abiague, A. "Bose-like oscillator in fractional-dimensional space." Journal of Physics A: Mathematical and General 34, no. 14 (March 30, 2001): 3125–38. http://dx.doi.org/10.1088/0305-4470/34/14/317.
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Aboanber, Ahmed Ebrahim, and Abdallah Alsayed Nahla. "Generalization of the analytical inversion method for the solution of the point kinetics equations." Journal of Physics A: Mathematical and General 35, no. 14 (March 28, 2002): 3245–63. http://dx.doi.org/10.1088/0305-4470/35/14/307.
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Horvat, Martin, and Tomaz Prosen. "Wigner function statistics in classically chaotic systems." Journal of Physics A: Mathematical and General 36, no. 14 (March 27, 2003): 4015–34. http://dx.doi.org/10.1088/0305-4470/36/14/307.
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Hunter, Kieran, Erika Andersson, Claire R. Gilson, and Stephen M. Barnett. "Maximum fidelity for a mirror symmetric set of qubit states." Journal of Physics A: Mathematical and General 36, no. 14 (March 27, 2003): 4159–72. http://dx.doi.org/10.1088/0305-4470/36/14/317.
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Chang, Zhiwei, Xiao-Lei Liu, Dan-Dan Yu, Hui-Qiong Han, Jian He, Rui-Rui Wang, Yong-Xu Jia, Jie Yan, and Yanru Qin. "Update results of anlotinib combined with penpulimab and nab-paclitaxel as first-line treatment for advanced esophageal squamous cell carcinoma (ESCC): A single-arm, open-label phase II clinical trial." Journal of Clinical Oncology 42, no. 16_suppl (June 1, 2024): e16017-e16017. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e16017.
Abstract:
e16017 Background: Recently, PD-1 blockades combined with dual chemotherapy in first-line setting exhibited encouraging efficacy for patients with ESCC. However, the safety profile of conventional dual chemotherapy remained unsatisfactory. Therefore, PD-1 blockades combined with anti-angiogenic tyrosine kinase inhibitors (TKIs) and single chemotherapy regimen might be a promising strategy. Anlotinib, a novel multitarget TKI primarily targeting VEGFR1-3, demonstrated promising therapeutic activity as first-line combination therapy or second-line monotherapy for patients with ESCC in China clinically. Therefore, this study was designed to explore the efficacy and safety of anlotinib combined with penpulimab (PD-1 blockade) and nab-paclitaxel as first-line therapy in advanced ESCC. Preliminary results were presented at the 2024 ASCO-GI Symposium (Abs 340), the consecutively updated results were presented in this report. Methods: Patients with previously untreated metastatic or locally advanced ESCC were recruited and treated with anlotinib (12mg, po, d1~14, q3w) and penpulimab (200mg, iv, d1, q3w) plus nab-paclitaxel (220mg/m2, iv, d1, q3w) until disease progression or unacceptable toxicity. The tumor response was assessed according to RECIST 1.1 using CT scans every two cycles. Adverse events were recorded by severity in accordance with the NCI CTC AE Version 5.0. The predefined sample size was 30. Primary endpoint was PFS and secondary endpoints included safety, ORR, DCR and OS. Results: From Jul 2022 to Dec 2023, a total of 27 patients were enrolled, 25 patients who had received first tumor response were included in this analysis. The best overall response indicated that there were 1 CR (4.0%), 18 PR (72.0%), 3 SD (12.0%) and 3 NE (12.0%). Therefore, the preliminary ORR was 76.0% (95%CI: 54.9%-90.6%), DCR was 88.0% (95%CI: 68.8%-97.5%). Median PFS of the 25 patients was not yet reached. Additionally, safety profile exhibited that the regimen was tolerable. The most common treatment-emergent adverse events among the 27 patients with the incidence > 20% were anemia (40.7%), peripheral nerve toxicity (37.0) and white blood cell decreased (25.9%). Common grade ≥3 treatment-emergent adverse events were white blood cell decreased (7.4%), diarrhea (3.7%), glutamic-pyruvic transaminase was elevated (3.7%), glutamic oxalacetic transaminase increased (3.7%), hypertension (3.7%) and immune enteritis (3.7%). Conclusions: The combination of anlotinib plus penpulimab and nab-paclitaxel as first-line therapy for advanced ESCC demonstrated promising efficacy and manageable safety profile. And the conclusions needed to be confirmed in subsequent trials.
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Akhmedova, Patimat Magomedovna. "Study of tomato breeding forms based on a complex of biological and economic characteristics." Agrarian Scientific Journal, no. 12 (December 13, 2022): 10–14. http://dx.doi.org/10.28983/asj.y2022i12pp10-14.
Abstract:
In Dagestan, there are local varieties of tomatoes that have valuable economic and biological characteristics: good yield, excellent taste qualities of fruits, high technological qualities, etc. In this regard, the Apple variety is of interest. However, the Apple variety is uneven and represents a motley population. There are deviations – low-yielding, weak-leaved, strongly exposed to sunburn, with different fruit shapes from rounded to flat. Fruit ripening also occurs at different times. Some plants bear fruit early, others-late. The research was carried out in order to improve the local Apple variety by the method of intra-variety family selection. The forms that meet the set goals are highlighted. These include numbers 22.43 and 56 from the early–maturing group, mid–late - 1a, 3, 3a, and 6a. Early–ripening forms 22, 43 and 56 had an advantage over the control in yield by 4.0 - 12.4 t/ha, i.e. by 7.1 - 22.1%, yield of commercial fruits by 5.9 -14.4t/ha or by 11.6 -28.5%, early yield by 1.4 – 3.7 t/ha. Mid-late - 3a, 1a, 3, 6a, had a yield higher by 5.0 – 11.3 t/ha or 10 -11.3%, the yield of commercial fruits was 6.8 -12.8 t/ha or 13.4 – 25.3% more than the control. According to the early harvest, number 6a stood out. Its harvest for the first collections was obtained above the control by 7.8 t / ha.
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Yeo, T. L., K. B. Ozanyan, F. Hindle, N. R. J. Poolton, and H. McCann. "Characteristics of Gasoline Fluorescence Using 404-nm Semi-Conductor Laser Diode Excitation." Applied Spectroscopy 56, no. 7 (July 2002): 846–51. http://dx.doi.org/10.1366/000370202760171509.
Abstract:
The recent availability of reliable and relatively low-cost GaN based semi-conductor laser diode sources emitting at 404 nm has opened many new areas for fluorescence based measurements. This article characterizes the fluorescence behavior of commercial liquid-phase gasoline samples using such excitation sources. Comparison is drawn with the emission when excited using broad-band sources at shorter wavelengths (340 nm). Here, 404 nm is shown to selectively excite the larger C xH y polycyclic aromatic hydrocarbons (PAH) commonly found as minor constituents of gasoline, mainly for ( x, y) ≥ (14, 10). Both Stokes and anti-Stokes shifted emission was observed in all the gasoline tested and in some PAH samples. The fluorescence is usually superimposed on Raman scattered laser light, arising from vibrations within the basic benzene structures. The fluorescence features of the gasoline samples tested were found to be broadly similar, but, because of its distinctive spectroscopic features, the fluorescence arising from benzo(a)pyrene was found to be one of the main variants. More generally, principal component analysis of the spectra was able to highlight differences between both the sample provenance and the fuel variety.
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Golyshko, Valentina S., V. A. Snezhitskiy, N. V. Matsiyeueskaya, and N. I. Prokopchik. "The frequency and characteristics of cardiovascular pathology in HIV-infected patients (according to aytopsy)." Clinical Medicine (Russian Journal) 95, no. 10 (December 4, 2017): 928–34. http://dx.doi.org/10.18821/0023-2149-2017-95-10-928-934.
Abstract:
Aim to study the frequency and structure of the cardiovascular diseases (CVD) deaths from HIV-infected patients. A retrospective analysis of medical records of 346 deaths of HIV-infected patients: 225 (65%) males (95% confidence interval - 95% CI 69,8-58,8) and 121 (35%) women (95% CI 30,1-40,1) at the age of 35.0 [32,0;38,0] years. Autopsy was performed in 150 (43,5%) patients (95% CI 38,2-48,6). GCC is installed in 77 (22.3 %) of 346 cases (95% CI of 18.2-26.9) . While 18 (5,2%) patients (95% CI 3,3-8,1) CVD was the main cause of death in 59 (17,1%) - concomitant diseases (95% CI 13,5-1,4). The structure of the CVD were presented with acute heart failure in 17 (4,9%) autopsy cases (95% CI 3,1-7,7) , hydropericardium - 14 (4.0%) of cases (95% CI 2,4-6,7), coronary heart disease in 14 (4.0%) of cases (95% CI 2,4-6,7), cardiomyopathy in 11 (3,2%) cases (95% CI 1,8-5,6), myocarditis in 10 (2.9%) cases (95% CI 1,6-5,2), infective endocarditis in 4 (1.2%) cases (95% CI 0.5-3.0), chronic pulmonary heart, in 4 (1.2%) cases (95% CI 0.5-3.0), effusion in 3 (0.9%) cases (95% CI 0,3 - 2,5). The defeat of the cardiovascular system in HIV-infected patients in 79,2% of cases were formed against the background of generalized of severe opportunistic infections and diseases. In patients not receiving antiretroviral therapy, have higher rates of death AIDS-associated CVD as compared to that in patients receiving therapy: 3,8% (95% CI 1.9-7,3) and 0 respectively (p=0.05).
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Mostafa, Nadia M., Laila Abdel-Fattah, Soheir A. Weshahy, Nagiba Y. Hassan, and Shereen A. Boltia. "Stability-Indicating Spectrofluorometric Method for the Determination of Some Cephalosporin Drugs via Their Degradation Products." Journal of AOAC INTERNATIONAL 98, no. 2 (March 1, 2015): 361–70. http://dx.doi.org/10.5740/jaoacint.14-088.
Abstract:
Abstract A stability-indicating spectrofluorometric method was investigated for the determination of three cephalosporin drugs, namely, cefpodoxime proxetil (CPD), cefixime trihydrate (CFX), and cefepime hydrochloride (CPM), via their acid and alkali degradation products. The three drugs were determined via their acid degradation at 432, 422, and 435 nm using an excitation wavelength of 310, 330, and 307 nm for CPD, CFX, and CPM determination, respectively, and via their alkali degradation at 407, 411, and 405 nm using an excitation wavelength of 310, 305, and 297 nm for CPD, CFX, and CPM determination, respectively. Linearity was achieved in the ranges of 0.35–3.50,0.4–4.0, and 0.3–3.0 μg/mL for the acid degradation products of CPD, CFX, and CPM, respectively, and in ranges of 0.05–0.5, 0.1–1.0, and 0.08–0.80 μg/mL for the alkali degradation products of CPD, CFX, and CPM, respectively. The method was validated for various parameters according to International Conference on Harmonization guidelines. The method was successfullyapplied for the determination of these cephalosporindrugs in pharmaceutical dosage forms with good accuracy and precision. The results obtained by the proposed spectrofluorometric method were compared with good agreement to the official HPLC method.
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Rosengarten, M. Yu, and L. D. Semenova. "Surgical care and ways to improve it in Tataria." Kazan medical journal 70, no. 1 (February 15, 1989): 1–4. http://dx.doi.org/10.17816/kazmj99725.
Abstract:
There are 75 medical preventive establishments, including RSB, RSB-2, DRKB, 11 city hospitals, 39 central republican hospitals, 2 regional, 14 district hospitals, 3 medical dispensaries, 3 dispensaries in TASSR.The number of surgeons per 10 000 inhabitants in 1987 is 3,6 (2,95 in 1978), beds per 10 000 inhabitants - 18,9 (16,8 in 1978). There is an insufficient number of trauma care beds in TASSR: 2,6 (in RSFSR - 4,0), oncological - 1,8 (in RSFSR - 2,3), proctological - 0,4 (in RSFSR - 0,6). The average number of bed days in 1987 for surgical patients was 332 in urban hospitals, and 327 in rural ones.
31
Nived, Ola, Per B. Johansen, and Gunnar Sturfelt. "Standardized Ultraviolet-A Exposure Provokes Skin Reaction in Systemic Lupus Erythematosus." Lupus 2, no. 1_suppl (February 1993): 247–50. http://dx.doi.org/10.1177/0961203393002001111.
Abstract:
The immediate, 1 day and 14 days skin reaction was determined in 23 female SLE patients and 23 age-matched controls after standardized exposure to ultraviolet light of the UV-A wavelengths (320-440 nm). Eighteen of the patients and 12 of the controls were photosensitive by history. Eight separate sites on the buttocks were exposed to UV-A light, four sites at doses between 42 and 252 kJ/m2 and four sites with longpass filters (320, 345, 360 and 375 nm). The reactions on test sites were graded by two independent observers unaware of given doses or filter location. All patients and controls reacted with immediate erythema irrespectively of the presence or absence of photosensitivity. After 1 day, 39% of controls and 78% of patients had erythema and the reactions were more pronounced to longwave UV-A light (>320 nm) in the patients (P < 0.001). After 14 days, six patients, but no control, had persistent erythema (P = 0.04). Interestingly, three of the four patients without anamnestic photosensitivity did not react on days 1 or 14, while the pattern seen in the controls on day 1 was totally unpredictable with regard to reported photosensitivity. These findings strongly suggest that a considerable proportion of SLE patients show pathological skin reactions to physiological doses of longwave UV-A and not only the far more studied shortwave UV-B (290-320 nm). The responsible chromatophore for the UV-A reaction is not known.
32
Wilson, Gary M., W. Kelley Thomas, and Andrew T. Beckenbach. "Intra- and inter-specific mitochondrial DNA sequence divergence in Salmo: rainbow, steelhead, and cutthroat trouts." Canadian Journal of Zoology 63, no. 9 (September 1, 1985): 2088–94. http://dx.doi.org/10.1139/z85-307.
Abstract:
Two forms of Salmo gairdneh with different life histories (steelhead and rainbow trout) were compared using restriction endonuclease analysis of mitochondrial DNA. A total of 19 individuals from four populations were studied for each of the two forms, using 14 restriction enzymes. In addition, five cutthroat trout samples were included as an interspecific comparison. These enzymes revealed a total of 81 cut sites, representing a sample of more than 400 nucleotides per fish. Of these sites, 25 were phylogenetically informative, dividing the 43 fish into 10 clonal lines, 8 Salmo gairdneri and 2 Salmo clarki. Results indicated detectable divergence between all geographic populations of steelhead and rainbow trout except Pennask rainbow trout, Coquihalla steelhead, and Wampus Creek rainbow trout. Other steelhead populations analysed showed a closer phylogenetic relationship to each other than to rainbow trout populations analysed. Intraspecific divergence was in most cases 1% or less, with a 1.5% maximum. Interspecific divergence between S. gairdneri and S. clarki was between 2% and 3.5%.
33
Vareesangthip, Kornchanok, and Andrew Davenport. "Comparison of measuring serum osmolality and equations estimating osmolality in peritoneal dialysis patients." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 40, no. 5 (January 13, 2020): 509–12. http://dx.doi.org/10.1177/0896860819896135.
Abstract:
The osmolar gap increases with kidney failure. A number of equations have been proposed to calculate serum osmolality, allowing determination of the osmolar gap by comparison with measured osmolality. As glucose and icodextrin absorption can potentially interfere with the laboratory measurement of serum sodium, a key component in equations calculating osmolality, we reviewed the performance of 14 equations used to calculate serum osmolality compared to the measurement of serum osmolality in 144 patients with peritoneal dialysis (PD); 81 (56.3%) males, 76 (52.5%) diabetics, mean age of 64.4 ± 16.3 years, 115 (79.9%) prescribed icodextrin and 38 (26.4%) 22.7 g/L glucose dialysates. Measured serum osmolality was 311 (304–320) mosmo/kg (mmol/kg), whereas calculated osmolality for the 14 equations ranged from a median of 274 (269–284) mosmo/kg to 307 (300–316) mosmo/kg. Bland–Altman mean bias showed that measured serum osmolality was greater than the calculated osmolality ranging from 4.0 mosmo/kg to 36.2 mosmo/kg between the 14 equations, with wide 95% limits of agreement (LoA) ranging from −27.1 mosmo/kg to 19.4 mosmo/kg and from −58.5 mosmo/kg to −13.8 mosmo/kg. Only 2 of the 14 equations gave a mean osmolar gap of <10 mosmo/kg and showed no systematic bias, median serum osmolality of 307 (300–316) and 303 (298–312) mosmo/kg, Spearman ρ of 0.57, 0.62, both p < 0.001, respectively. Our study would suggest that only 2 of the 14 equations we compared with measured serum osmolality showed no systematic bias, but still had too great a bias to be useful in clinical practice. As such we propose a new equation to calculate serum osmolality in patients with PD.
34
Vadchenko, S. G., A. S. Sedegov, and I. D. Kovalev. "Thermal explosions in (Ti, Zr, Hf, Nb, Ta) carbon mixtures." Powder Metallurgy аnd Functional Coatings 17, no. 3 (September 19, 2023): 14–21. http://dx.doi.org/10.17073/1997-308x-2023-3-14-21.
Abstract:
This research focuses on investigating the ignition and thermal explosion behavior of (Ti, Zr, Hf, Nb, Ta) + 5C mixtures that have been mechanically activated. First, we mechanically activated the metal powder mixtures to produce composite particles consisting of Ti, Zr, Hf, Nb, and Ta, followed by the addition of carbon, and re-activation. An activation time of 120 min at 347 rpm resulted in the formation of solid solutions from the metals in the mixture, while large tantalum particles were preserved. The resulting mixtures were then pressed into pellets, which were heated in argon until ignition occurred. The ignition process involves multiple phases, with the first being inert heating, followed by progressive heating at t = 420÷450 °C, and a subsequent endothermic phase transformation at 750–770 °C. The temperature then rises rapidly, resulting in a thermal explosion that forms complex carbides, leaving some unreacted tantalum behind. The (Ti, Zr, Hf, Nb, Ta)C5 activated mixtures and high entropy solid solution are unstable and release titanium and zirconium carbides when heated above 1300 °C, causing changes to the composition of the (Ti, Zr, Hf, Nb, Ta)C5 final product. When diluted by adding 25 and 50 % of the final product, the effective activation energy Ea for the (Ti, Zr, Hf, Nb, Ta) + 5C reaction in the 1100–1580 °C temperature range was found to be 34 kJ/mol.
35
Sarosiek, Shayna R., Gottfried R. von Keudell, Jonas Paludo, Monika Salkar, Barnabie Agatep, Anjali Franco, Samuel Crawford, Michelle Pacia, and Jorge J. Castillo. "Real-World Outcomes Following Dose Modifications of First-Line Ibrutinib in Patients with Waldenström Macroglobulinemia." Blood 142, Supplement 1 (November 28, 2023): 3780. http://dx.doi.org/10.1182/blood-2023-181925.
Abstract:
Background: In patients with Waldenström macroglobulinemia (WM), continuous once-daily ibrutinib-based therapy has been associated with long-term progression-free survival. In addition, patients who continued ibrutinib-based treatment had better survival outcomes than those who discontinued treatment within the first few years. Evidence based on a single-center retrospective study suggests that dose reduction (DR) can be used to effectively manage ibrutinib-related adverse events (AEs) and avoid early treatment discontinuation. However, real-world data on outcomes in patients with WM after ibrutinib DR are limited. In this real-world study, we analyzed short-term (1-year follow-up) dosing patterns and time to treatment discontinuation (TTD) in patients with WM, with and without DR, who were receiving first-line (1L) ibrutinib. Methods: Medicare Fee-for-Service closed-claim medical or pharmacy records were used to identify patients diagnosed with WM who initiated 1L single-agent ibrutinib (420 mg/day) from January 2014 to December 2020. Observed patients were enrolled in Medicare ≥12 months before and after ibrutinib initiation and had post-initiation AEs (both prevalent and incident AEs with DR recommendation from the US Prescribing Information), as identified via ICD-9 or ICD-10 codes. Ibrutinib DR was defined as a reduction of the starting dose following the first AE within the 1-year follow-up period. Patients without a DR were defined as those who had received ibrutinib 420 mg per day during the 1-year follow-up period. Patients with a DR in the absence of AEs and patients with a DR prior to any AE were excluded from the analysis. Demographics, clinical characteristics, time to first AE, and TTD were analyzed among cohorts with and without DR. TTD was defined and evaluated as the time from first observed AE after ibrutinib initiation to the earliest occurrence of (1) a gap of >120 days between the end of 1L therapy and the follow-up period, (2) initiation of a next line of therapy, or (3) death. TTD was analyzed using Kaplan-Meier methodology, log rank test, and a Cox proportional hazards model adjusted for baseline and time-varying covariates. Results: We identified 404 patients (DR, n = 58 [14%]; no DR, 346 [86%]). Overall, 249 patients (62%) were men, 267 patients (66%) had hypertension, 55 patients (14%) had atrial fibrillation, and 114 patients (28%) had other cardiovascular conditions at baseline. The mean ± SD age at baseline was 77 ± 8 years. In both cohorts, the median Charlson Comorbidity Index was 4.0. Among the 404 patients, mean ± SD time from ibrutinib initiation to first AE was 28 ± 44 days. Mean ± SD time between first AE and DR was 137 ± 102 days. Mean TTD was 8.3 months (DR) and 6.2 (no DR) ( P = 0.018; Figure). At 6 and 12 months of follow-up, fewer patients with DR discontinued treatment compared with patients without DR (6 months: 24% vs 46%, P = 0.002; 12 months: 36% vs 50%, P = 0.064). After controlling for baseline and time-varying demographic and clinical characteristics, patients with DR were not significantly more likely to discontinue treatment compared with patients without DR (hazard ratio [95% CI], DR vs no DR: 1.24 [0.86-1.78]). Conclusion: These short-term (1-year follow-up) findings suggest TTD was not impacted by DR of ibrutinib following AEs. Thus, ibrutinib DR can be an effective strategy to manage AEs while maintaining clinical efficacy. Of note, causal association between AE and subsequent DR cannot be inferred from the claims database due to the cross-sectional nature of this study.
36
Saunders, Andrew. "Book reviewsClinics in diagnostic ultrasound, 14. Co-ordinated diagnostic imaging. Edited by SimeoneJoseph, pp. xiv + 345, 1984 (Churchill Livingstone, New York/Edinburgh), £36.00. ISBN 0–443–08296." British Journal of Radiology 58, no. 691 (July 1985): 598. http://dx.doi.org/10.1259/0007-1285-58-691-598-c.
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Sieber, C. C., P. G. Mosca, and R. J. Groszmann. "Effect of somatostatin on mesenteric vascular resistance in normal and portal hypertensive rats." American Journal of Physiology-Gastrointestinal and Liver Physiology 262, no. 2 (February 1, 1992): G274—G277. http://dx.doi.org/10.1152/ajpgi.1992.262.2.g274.
Abstract:
Vasoactive effects of natural somatostatin (SRIF-14) and its analogue octreotide were studied in in vitro perfused superior mesenteric arterial beds of normal (Sham) and portal hypertensive (PVL) rats. Tested concentrations covered the whole range used in clinical settings (10(-10) to 10(-5) M for SRIF-14 and 10(-11) to 10(-6) M for octreotide, respectively). Vessel resistances only minimally changed to infusions of SRIF-14 (from 3.5 +/- 0.4 to 3.7 +/- 0.5 mmHg.ml-1.min and 3.8 +/- 0.3 to 3.9 +/- 0.4 mmHg.ml-1.min for PVL and Sham) and octreotide (from 3.3 +/- 0.2 to 3.4 +/- 0.4 mmHg.ml-1.min and 3.8 +/- 0.4 to 4.0 42- 0.4 mmHg.ml-1.min for PVL and Sham). The same was true for bolus injections. In contrast, norepinephrine induced significant increases in vessel resistance (up to 110.6 +/- 20.1 mmHg.ml-1.min). In conclusion, SRIF-14 and octreotide exert no direct effect on vascular smooth muscle tone in splanchnic resistance vessels of Sham and PVL rats. The vasoconstriction reported in vivo seems therefore probably mediated by the ability of these peptides to inhibit the secretion of vasodilatatory substances.
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Nursyahra, Muhammad Rizki, and Rizki. "Efektivitas Bokashi Daun Kelapa Sawit (Elaeis guineensis Jacq) Terhadap Produksi Kacang Kedelai (Glycine max (L.) Merr.) di Pasaman Barat." Biotropic : The Journal of Tropical Biology 4, no. 1 (February 29, 2020): 8–14. http://dx.doi.org/10.29080/biotropic.2020.4.1.8-14.
Abstract:
The low production of soybeans in the West Pasaman district is due to severeal factors, including the lack of community knowledge in soybean farming which results in less productive yields obtained by farmer and the high use of inorganic fertilizers continuously resulting in less productive soil. This study was experimental research using a completely randomized design (CRD). The treatments given were 6 treatments and 5 replications, the treatments used were 15 gram TSP (A treatment) as control treatments, 300 gram bokashi (B treatment), 400 gram bokashi (C treatment), 500 gram bokashi (D treatment), 600 gram bokashi (E treatment), 700 gram bokashi (F treatment). The data obtained were analyzed by analysis of variance and then continued by LSD test at α level of 5%. Observed parameters were the number of planting seeds and weight of 50 seeds per plant. The results of this study indicated that bokashi fertilizer had no significant effect on the number of seeds but it had significant effect on the weight of 50 seeds and the best result was found in B treatment (300 gram bokashi/polybag). This research had environmental conditions with temperatures of 30 – 340 C, environmental humidity of 63 – 80%, wind speeds of 0,2 to 2,8 m/s, and soil pH of 5,4 to 7,0.
39
Sinaga, Maria Magdalena, Djagal Wiseso Marseno, and Manikharda Manikharda. "Application of Liquid Smoke from Rubber Wood Clone PB-340 as Latex Coagulant and Preservation of Natural Rubber Coagulum." agriTECH 43, no. 1 (February 28, 2023): 85. http://dx.doi.org/10.22146/agritech.70487.
Abstract:
The utilization of rubber wood waste in the form of liquid smoke has the potential to overcome environmental problems caused by the industry. Therefore, this study aimed to determine the potential of liquid smoke from rubberwood clone PB 340 to be used as a coagulant and preservative. Rubber wood waste was processed into liquid smoke using the pyrolysis method with a temperature of 400°C. Determination of the composition of liquid smoke was carried out using gas chromatography-mass spectrometry (GC-MS) analysis. The results showed that the rubber wood clone PB 340 contained 57.78% cellulose, 12.16% hemicellulose, and 19.01% lignin. Furthermore, volatile analysis with GC-MS showed that liquid smoke from rubber wood clone PB 340 contained 58 organic compounds. Some compounds in liquid smoke were phenols, furans, furfurals, acetic acid, and cyclopentene. The product was then tested for its performance as a latex coagulant at several concentrations of 5%, 10%, 15%, 20%, and 25% v/v, as well as storage time of 1, 7, and 14 days. The treated latex samples that had turned into coagulums were examined for their sheet quality parameters, including initial plasticity (P0), plasticity retention index (PRI), total volatile compounds, impurity, and ash content. The outcomes from all comparisons of pure liquid smoke concentrations and storage time of up to 14 days of the coagulum samples showed that in the initial plasticity value (P0), the plasticity retention index (PRI), volatile matter, ash content, and dirt content had met the applied Standard Indonesian Rubber (SIR).
40
WALLACH, VAN, and FRANK GLAW. "A new mid-altitude rainforest species of Typhlops (Serpentes: Typhlopidae) from Madagascar with notes on the taxonomic status of T. boettgeri Boulenger, T. microcephalus Werner, and T. capensis Rendahl." Zootaxa 2294, no. 1 (November 20, 2009): 23–38. http://dx.doi.org/10.11646/zootaxa.2294.1.2.
Abstract:
We describe a new Typhlops species from mid-altitude rainforest (ca. 950 m elevation) of the Andasibe region in central eastern Madagascar. Typhlops andasibensis sp. nov. is a medium-sized species (up to 340 mm total length) and can be separated from all other Malagasy typhlopids by the combination of 26 midbody scale rows, less than 400 middorsals, and a T–V supralabial imbrication pattern. Typhlops microcephalus is confirmed as a valid species, T. boettgeri is resurrected from the synonymy of T. arenarius, and T. capensis is synonymized with Ramphotyphlops exocoeti. Keys to the three genera and 14 described species of Madagascar and Comoro typhlopids are provided.
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ter AVEST, Ewoud, Suzanne HOLEWIJN, Anton F. H. STALENHOEF, and Jacqueline de GRAAF. "Variation in non-invasive measurements of vascular function in healthy volunteers during daytime." Clinical Science 108, no. 5 (April 22, 2005): 425–31. http://dx.doi.org/10.1042/cs20040300.
Abstract:
Although it is often recommended to standardize the time of day when performing non-invasive measurements of vascular function, the exact influence of the time of day on the outcome of IMT (intima-media thickness), PWV (pulse wave velocity), AIX (augmentation index) and FMD (flow-mediated dilatation) measurements has not been reported before. Nineteen healthy volunteers visited our department on two different occasions: the first visit was at 09:00 hours after an overnight fast, and the second visit was at 14:00 hours after a standardized breakfast. Non-invasive measurements of atherosclerosis were performed twice at 09:00 hours and once on the second visit at 14:00 hours. Measurement of IMT, PWV, AIX and FMD was reproducible according to the method of Bland and Altman. The absolute difference between repeated measurements at 09:00 hours showed no significant difference compared with the absolute difference between 09:00 and 14:00 hours for IMT (0.029±0.014 compared with 0.021±0.014 mm; P=0.27), PWV (0.63±0.50 compared with 0.75±0.74 m/s; P=0.52), AIX (4.0±4.0 compared with 5.5±5.2%; P=0.35) and FMD (3.8±3.7 compared with 4.2±2.9%; P=0.70). In conclusion, our results show that, in healthy volunteers during the daytime, IMT, PWV, AIX and FMD outcomes are not confounded by variation in the exact time of the examination as long as other (exogenous) conditions, including food intake, smoking and intake of alcohol, are carefully controlled for.
42
Baumann, Brian C., Jiwei He, Wei-Ting Hwang, Kai Tucker, Justin E. Bekelman, Harry W. Herr, Seth P. Lerner, et al. "Validating a local failure risk stratification for use in a prospective study of adjuvant radiation in bladder cancer." Journal of Clinical Oncology 33, no. 7_suppl (March 1, 2015): 347. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.347.
Abstract:
347 Background: To inform the design of trials of adjuvant radiation (RT) for bladder cancer, a local failure (LF) risk grouping has been proposed and externally validated that stratifies radical cystectomy (RC) pts into 3 groups based on pathologic factors. This stratification was developed using historical surgical databases and may not reflect outcomes in the observation arm of a modern trial. The purpose of the study is to assess whether trial accrual bias or improving surgical techniques over time impact the validity of the stratification or reduce the LF risk estimates for each subgroup. Methods: The LF stratification was developed using 2 cohorts treated with RC +/- chemo: a single-institution cohort of 442 pts (1990-2008) and the multi-center SWOG 8710 cohort of 264 pts (1987-1998). To assess the impact of trial accrual bias, we excluded pts who developed LF, DM, died, or were lost to follow up <90 days from surgery or completing post-op chemo as these pts are very unlikely to be enrolled in an adjuvant RT trial. 3-yr LF rates were estimated using Gray’s test. The stratification was considered valid if all 3 risk groups had significantly different LF rates. To assess the impact of improving surgical techniques over time, a Fine-Gray regression estimated the association of LF and year of RC while controlling for risk group. Results: Using the stricter criteria, 10% of SWOG pts and 14% from the other cohort were excluded. Analysis of the remaining pts confirmed 3 subgroups with significantly different LF risk: low risk (stage ≤pT2), intermediate risk (≥pT3 with negative margins and ≥10 nodes identified at surgery), and high risk (≥pT3 with positive margins OR <10 nodes identified) with 3-yr LF rates of 7%, 17%, and 36%, respectively (p<0.01), nearly identical to the rates when not accounting for accrual bias. Year of RC was not associated with LF risk on univariate analysis or after controlling for risk group in the SWOG, single-institution, or combined cohorts. Conclusions: These results suggest that neither trial accrual bias nor improvements in surgical techniques over time invalidate the LF risk stratification or substantially affect LF estimates. The proposed stratification is promising for use in adjuvant RT trials.
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Nguyen, Van Loi, Vu Dung Luu, Thi Minh Phuong Vu, and Van Tam Vu. "Nghiên cứu một số yếu tố liên quan đến kết quả sử dụng vòng nâng cổ tử cung trong điều trị dự phòng sẩy thai và sinh non ở Bệnh viện Phụ Sản Hải Phòng." Tạp chí Phụ sản 16, no. 4 (June 1, 2019): 45–49. http://dx.doi.org/10.46755/vjog.2019.4.567.
Abstract:
Nghiên cứu mô tả cắt ngang trên 125 thai phụ đã được đặt vòng nâng cổ tử cung tại Bệnh viện Phụ Sản Hải Phòng từ tháng 4/2016 đến tháng 4/2018.
Mục tiêu: Nghiên cứu một số yếu tố liên quan đến kết quả sử dụng vòng nâng cổ tử cung trong điều trị dự phòng sẩy thai và sinh non ở Bệnh viện Phụ Sản Hải Phòng.
Kết quả: Tuổi thai trung bình khi sinh ở những thai phụ đặt vòng nâng cổ tử cung (CTC) là 34,7±4,9 tuần, tỷ lệ sinh từ 28 tuần đến đủ tháng là 91,2%, tỷ lệ sơ sinh sống là 90,4%. Các yếu tố ảnh hưởng có ý nghĩa thống kê đến hiệu quả vòng nâng CTC: điều trị phối hợp (OR=0,1, 95%CI: 0,03-0,4), tuổi thai khi đặt vòng nâng CTC (OR=4,0, 95%CI: 1,6-8,3), tiền sử sinh non (OR=3,5, 95%CI: 1,6-7,9), tiền sử khâu vòng CTC (OR=3,7, 95%CI: 1-14), xuất hiện cơn co tử cung sau đặt vòng nâng CTC (OR=2,6, 95%CI: 1,0-6,4).
Kết luận: Các yếu tố điều trị phối hợp (thuốc/ hoặc phối hợp khâu vòng CTC); đặt vòng nâng CTC khi tuổi thai dưới 20 tuần làm giảm tỷ lệ sinh non khi đặt vòng nâng cổ tử cung (p<0,05); tiền sử khâu vòng cổ tử cung, tiền sử sinh non làm tăng tỷ lệ sinh non khi đặt vòng nâng CTC (p<0,05).
44
Sreejamol, MG, R. Radhika, and Rajalakshmi Reghuvaran. "Selfitis: An Analysis on Prevalence and Attitude among College Students." Indian Journal of Psychiatric Nursing 20, no. 2 (2023): 133–36. http://dx.doi.org/10.4103/iopn.iopn_49_22.
Abstract:
Abstract Introduction: Our daily lives now mostly revolve around our smartphones. Due to the widespread use of mobile phones, selfies have become the newest technical trend among young people. The most common practice of taking selfies in dangerous situations is proving to be a fatal one. The majority of these fatalities and injuries are from falls from great heights and posing with dangerous objects. Objective of the Study: The objective of this study was to assess the attitude and prevalence of selfitis among college students. Methodology: Descriptive design was used in this study. Convenience sampling technique was used to select 400 college students from a technical college of Ernakulam district, Kerala, within the age group of 16–24 years. The data were collected using two semi-structured questionnaires and Solanki Selfie Addiction Scale, a standardized tool for the assessment of selfie addiction. Results: It was found that 86% (344) were males and 14% (56) were females. Eighty-five percentage (340) of the study subjects had smartphone and only a few, 60 (15%) were not using it. About 59.5% (238) of them used all the enlisted social media. The prevalence of selfie addiction shows majority, 260 (65%) had mild selfie addiction, 76 (19%) had no selfie addiction but few had moderate 64 (16%) selfie addiction, and there was no severe selfie addiction. Result of attitude shows that 82% (328) have a neutral attitude, 16% (64) shows a positive attitude, and 2% (8) shows a negative attitude toward selfie. Conclusion: The result highlights the importance of providing education regarding the healthy use of social media.
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Obukhova, Olga A., Ildar A. Kurmukov, Nail M. Egofarov, Mariya G. Kolesnichenko, Yuriy V. Kirillov, Svetlana S. Povaga, Natal’ya A. Belyaeva, et al. "Impact of perioperative high-protein nutritional support on postoperative outcomes in the treatment of primary lung cancer: Russian prospective multicenter comparative study (NUTRILUNC-study)." Clinical nutrition and metabolism 4, no. 3 (May 9, 2024): 150–64. http://dx.doi.org/10.17816/clinutr625481.
Abstract:
BACKGROUND: Up to 60% of lung cancer pts experience weight loss. Prevalence of sarcopenia in patients (pts) with non-small cell lung cancer (NSCLC) is about 43% and is an independent predictor of worse overall survival. It was shown that nutritional support improves outcomes in pts with cancer. AIM: To evaluate impact of perioperative nutritional support on surgical treatment outcomes of patients with NSCLC. MATERIALS AND METHODS: Patients with primary NSCLC (n=112, 69 males), aged 57,2±8,2, awaiting lung surgery and being at risk of malnutrition (Nutritional Risk Screening Assessment 2002 score ≥3) were randomized into 2 groups. Study group (n=55) received oral nutritional support (Nutridrink Compact Protein, Nutricia LLC), 250 ml/d (36 g of protein, 612 kcal) for 14 d before and 14 d after surgery in addition to standard diet. Control group (n=57) had a standard diet. The number of respiratory complications after surgery, length of hospitalization, anthropometric, functional, laboratory parameters, quality of life (according to Quality of Life Questionnaire Core-30) were assessed. Results were presented as mean ± standard deviation. Differences were considered significant at p ≤0.05. RESULTS: In the study group there were fewer respiratory complications (p 0.01), and a shorter length of hospitalization (p=0.03). Body weight in the study group did not change significantly, while in the control group it decreased (0.15±3.7 kg versus loss of 3.47±3.6 kg). Results of six-minute walk test and hand grip dynamometry were higher in the study group then in the control group (411.8±56.0 m versus 383.2±52.1 m; 33.5±8.4 kg versus 27.1±6.8 kg). Quality of life was better in the study group, p 0.05. The total protein and albumin levels were higher in the study group (70.9±5.6 g/l versus 63.1±4.0 g/l; 38.5±5.8 g/l versus 33.2±3.0 g/l). One patient in study group experienced 1st grade diarrhea. CONCLUSION: In patients with NSCLC at risk of malnutrition perioperative nutritional support with high protein oral nutritional support has a positive effect on surgical treatment outcomes.
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Huber, Stephan M., and Michael F. Horster. "Expression of a hypotonic swelling-activated Cl conductance during ontogeny of collecting duct epithelium." American Journal of Physiology-Renal Physiology 275, no. 1 (July 1, 1998): F25—F32. http://dx.doi.org/10.1152/ajprenal.1998.275.1.f25.
Abstract:
Developmental expression of ion channels possibly participating in regulatory volume decrease was studied in rat embryonic ( day E17) and perinatal ( days P1–6) ureteric bud and in postnatal ( P9–14) cortical collecting duct cells in primary monolayer culture. In isotonic bath solution, whole cell conductance (in nS/10 pF) was highest in E17 (4.0 ± 0.5, n = 31) compared with P1–6 (2.0 ± 0.1, n = 16) and P9–14 (1.3 ± 0.2, n = 12) due to a decreasing contribution of a DIDS-sensitive Cl conductance, from E17 (2.8 ± 0.7, n = 12) to P1–6 (0.53 ± 0.07, n = 9) and P9–14 (0.05 ± 0.1, n = 7). Cl conductance in E17 exhibited a permselectivity of I ≈ Cl ≈ Br ≫ gluconate, and it activated time dependently. Hypotonic bath solution induced a large increase of whole cell conductance in P1–6 and in P9–14 but not in E17 (by 20.0 ± 3.7, 21.5 ± 5.5, and 4.9 ± 1.7; n = 11, 12, and 25, respectively) due to the activation of a time-dependently inactivating Cl conductance with a permselectivity of I ≥ Br > Cl ≫ gluconate. In conclusion, the expression of Cl channels, as studied in vitro, appears to shift from an apparently constitutively active embryonic to a hypotonic swelling-activated type during late embryonic development of the collecting duct.
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Gleeson, C. M., W. J. Curry, C. F. Johnston, and K. D. Buchanan. "Occurrence of WE-14 and chromogranin A-derived peptides in tissues of the human and bovine gastro-entero-pancreatic system and in human neuroendocrine neoplasia." Journal of Endocrinology 151, no. 3 (December 1996): 409–20. http://dx.doi.org/10.1677/joe.0.1510409.
Abstract:
Abstract Antisera were generated to the synthetic peptides SREWEDS and KELTAE which correspond to residues 315–321 and 332–337 of human chromogranin A (CgA) respectively. KELTAE represents the C-terminal hexapeptide of WE-14, and SREWEDS (residue 316 human CgA Lys/Arg substitution) represents the C-terminal heptapeptide of the Intervening Peptide, located between pancreastatin and WE-14. The antisera were employed to study the occurrence of WE-14 and CgA-derived peptides in human and bovine gastro-entero-pancreatic (GEP) tissues and in a range of human GEP neuroendocrine tumours. Immunocytochemical analyses of normal human and bovine tissues demonstrated that each antiserum immunostained endocrine cells throughout the GEP tract. Variable intensities of immunostaining were detected in neoplastic tissues. Quantitatively, the highest levels of SREWEDS and KELTAE immunoreactivity were detected in pancreatic extracts, with lower levels in gastrointestinal tissues. Elevated levels of each immunoreactant were detected in neoplastic tissues. Chromatographic analysis resolved several SREWEDS-related peptides and a major KELTAE-related peptide that co-eluted with synthetic human WE-14. The present study has demonstrated that CgA is processed to generate distinct peptide products in normal and neoplastic tissues of the GEP system. A single molecular species co-eluting with synthetic human WE-14 was predominant and consistently detected in all the tissues studied. Journal of Endocrinology (1996) 151, 409–420
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Diener, Hans-Christoph, Piero Barbanti, Carl Dahlöf, Uwe Reuter, Julia Habeck, and Jana Podhorna. "BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: Results from a phase II study." Cephalalgia 31, no. 5 (December 20, 2010): 573–84. http://dx.doi.org/10.1177/0333102410388435.
Abstract:
Methods: Four hundred and sixty-one adult subjects with migraine were randomised to one of five treatments, the oral antagonist at the calcitonin gene-related peptide (CGRP) receptor BI 44370 TA (50 mg, 200 mg, 400 mg), active comparator eletriptan 40 mg or placebo. The analysis included 341 subjects who took study medication. Results: The primary endpoint, pain-free after two hours, was reached by significantly more subjects in the BI 44370 TA 400 mg (20/73 = 27.4%) and eletriptan 40 mg (24/69 = 34.8%) groups compared to placebo (6/70 = 8.6%, p = .0016), but not by subjects in the BI 44370 TA 200 mg group (14/65 = 21.5%). The effect of 50 mg BI 44370 TA (5/64 = 7.8%) was similar to that of placebo. Analysis of secondary endpoints supported the conclusion from the primary analysis. The frequency of adverse events was low in all groups. Conclusion: Efficacy of BI 44370 TA was shown in a dose-dependent manner in the treatment of acute migraine attacks.
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Naqeeb, Mohammed R., and Dina M. Abdulmannan. "Clinical Profiles of Obstructive Hydrocephalus in Patient with Von Hippel–Lindau." Majalah Kedokteran Bandung 56, no. 2 (June 29, 2024): 153–56. http://dx.doi.org/10.15395/mkb.3347.
Abstract:
Von-Hippel-Lindau (VHL) is an autosomal dominant disease that affects multiple systems that may result in benign and malignant multisystem tumors. The estimated incidence of VHL is 1 in 36,000 births. Disease incidence ranges from 10 to 40 years, with an average of 26 years, and it impacts diverse ethnic groups. VHL results from mutations in the germ line that have been mapped to chromosome 3P25. Currently, this is the only gene known to cause the syndrome. This study presented a case of obstructive hydrocephalus in a patient with VHL. A 19-year-old female was referred to the Eye Clinic for a diagnosis of papilledema. She began to experience vagal abdominal discomfort for no apparent reason. Per exam, the patient had 20/20 OD and 20/400 OS, with an intraocular pressure of 14 OU. The patient's MRI revealed a posterior fossa cranial cystic brain lesion that was obstructing the fourth ventricle and causing obstructive hydrocephalus. Early detection, management, and focal laser treatment of capillary hemangiomas in the retina's periphery led to favorable visual outcomes. Even after vitreoretinal surgery, the tumors may cause exudative retinal detachment and have an inferior visual prognosis if left untreated.
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Furman, Matthew Jason, Mitchell Cahan, Philip Cohen, Giles Francis Whalen, and Laura A. Lambert. "Association of interval appendectomy with risk of neoplasm." Journal of Clinical Oncology 30, no. 4_suppl (February 1, 2012): 430. http://dx.doi.org/10.1200/jco.2012.30.4_suppl.430.
Abstract:
430 Background: The role of interval appendectomy after conservative management of perforated appendicitis remains controversial. Determining the etiology of perforated appendicitis is one reason to perform interval appendectomies. This study hypothesizes that there is an increased rate of neoplasm in patients undergoing interval appendectomy. Methods: This is a retrospective review of all patients over 18 years of age who underwent appendectomy for presumed appendicitis from January, 2006 to December, 2010 at a single, tertiary care institution. Demographic data, pathologic diagnosis, clinico-pathologic characteristics, interval resection rate, and complication data were collected and analyzed. Results: During the study period, 376 patients underwent appendectomy. The mean age was 41 years (range 18 to 94). Interval appendectomy was performed in 18 patients (5.0%) (age 28 to 74). Neoplasms were identified in 14 patients (3.7 %); 6 were found in patients who had undergone interval appendectomy (33%). Nine were mucinous tumors (69.2%), 5 of which were associated with interval appendectomies. Neoplasms were identified in 8.3% of patients between 35 and 55 years old. Conclusions: Mucinous neoplasms of the appendix were found in 33% of patients undergoing interval appendectomy. Interval appendectomies should be considered in all patients 35 years and older due to increased risk of appendiceal neoplasm. [Table: see text]