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Catovsky, Daniel, Sue Richards, Estella Matutes, Anna Burford, Vasantha Brito-Babapulle, Claire Dearden, Philip Morris, and Andrew Pettitt. "Response to Therapy and Survival in CLL Is Influenced by Genetic Markers. Preliminary Analysis from the LRF CLL4 Trial." Blood 104, no. 11 (November 16, 2004): 13. http://dx.doi.org/10.1182/blood.v104.11.13.13.
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Abstract The randomised CLL4 trial was launched in 1999 to answer scientific and management issues. Since then, 730 patients with Binet stages A progressive, B and C have been randomised between 1) chlorambucil (10mg/m2 x 7 days), or 2) fludarabine (FDR) alone (40mg/m2 x 5 d oral or 25mg/m2 x 5 days IV), or FDR plus cyclophosphamide (FDR 24mg/m2 x 5 d oral or 25mg/m2 x 3 d IV plus cyclo 150mg/m2 x 5 d oral or 250mg/m2 x 3 d IV). Information on FISH analysis with 5 probes is available on 440 patients. The incidence of the genetic abnormalities is: 13q del (60%), trisomy 12 (15%), 6q del (8%), 11q del (19%), 17p del (11%); some markers are positive in more than one patient. Analysis by stage showed no differences in the distribution of these markers and analysis by age showed that patients with 13q del were younger (p=0.006) and those with 11q del were older (p=0.01). Analysis by response to all therapies (as the code of individual therapies has not been broken) in 343 patients is shown in Table 1. The results show clearly that almost half the patients with 17p del (p53 locus) are primary non-responders (NR) or show progressive disease (PD) following first line therapy, and have poor survival. 2yr survival of patients with none of these abnormalities was 87% (79%–95%), and using a hierarchical model with normals as the fifth group there was a clear trend in survival between groups (2p<0.00005). When the % of 17p del lymphocytes was correlated with response, it was apparent that the higher the % of 17p del cells the greater the proportion of non-responders (Table 2), with 20% 17p del being the critical threshold. When we grouped together cases with 6q, 11q and 17p deletion plus trisomy 12 (representing 42% of cases) there was a significantly lower response rate compared with the cases without those four abnormalities: CR/Nod PR 35% vs 47%, PR 33% vs 39%, and 32% vs 13%, (Chi-square 13.3; p=0.0003). This study demonstrates that the genetic abnormalities which can be shown in c.80% of patients with active CLL have a significant bearing on the response to treatment and early survival, confirming the survival differences reported by Dohner at al (N Engl J Med 343: 1910–16; 2000). It remains to be determined whether better therapies could overcome the low response rates of patients with poor prognostic genetic abnormalities. Table 1: FISH analysis by response (non-hierarchical) and survival Abnormality CR/Nod PR PR NR/PD p value* 2 yr survival (95% CI) * Analysis of individual abnormalities versus the rest; Chi-square test; **326 patients 17p del 33% 18% 48% 0.004 67% (50%–85%) 11q del 29% 44% 27% NS 73% (59%–86%) Trisomy 12 41% 31% 29% NS 72% (57%–87%) 6q del** 39% 29% 32% NS 75% (56%–95%) 13q del 42% 37% 21% NS 91% (86%–95%) Table 2: Correlation of response with proportion of 17p del lymphocytes % deletion No. cases CR/Nod PR PR NR/PD Chi-square 318.8; p<0.0001 <5 (negative) 310 43% 39% 18% 5–20 18 61% 22% 17% >20–100 15 0% 13% 87%
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Stieber, Mary. "A Note on A .AG. 410-28 and E. ALC. 347-56." Mnemosyne 52, no. 2 (1999): 150–58. http://dx.doi.org/10.1163/1568525991528851.
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Harlin, Matthew, Murat Yildirim, Pedro Such, Jessica Madera-McDonough, and Frank Larsen. "Pharmacokinetic Profile of Aripiprazole 2-Month Ready-to-Use 960 mg in Adult Patients With Schizophrenia or Bipolar I Disorder." CNS Spectrums 28, no. 2 (April 2023): 256. http://dx.doi.org/10.1017/s1092852923002006.
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AbstractIntroductionAripiprazole 2-month ready-to-use 960 mg (Ari 2MRTU 960) is a new long-acting injectable (LAI) antipsychotic formulation for gluteal administration every 2 months, intended for the treatment of schizophrenia and maintenance monotherapy treatment of bipolar I disorder (BP-I). This 32-week trial evaluated the safety, tolerability, and pharmacokinetic profile of multiple-dose administration of Ari 2MRTU 960 in clinically stable adult patients with a diagnosis of schizophrenia or BP-I, versus that of aripiprazole once-monthly 400 mg (AOM 400; an LAI indicated for the treatment of schizophrenia and maintenance monotherapy treatment of BP-I).MethodsThis was an open-label, multiple-dose, randomized, parallel-arm trial conducted at 16 sites in the US. Patients were randomized to receive Ari 2MRTU 960 every 56±2 days (n=132) or AOM 400 every 28±2 days (n=134). The primary objective was to establish the similarity of aripiprazole concentrations on the last day of the dosing interval, as well as exposure during the dosing interval (area under the concentration-time curve [AUC]), between Ari 2MRTU 960 and AOM 400 following multiple doses. It was pre-specified that the lower bound of the 90% confidence interval (CI) of the geometric means ratio (GMR) for these parameters must be >0.8.ResultsIn the Ari 2MRTU 960 group, 102 patients (77.3%) completed the study; in the AOM 400 group, 92 patients (68.7%) completed the study. The GMR of C56 for Ari 2MRTU 960 to C28 for AOM 400 was 1.011 (90% CI: 0.893, 1.145). The GMR (90% CI) of AUC0–56 for Ari 2MRTU 960 to AUC0–28 for AOM 400 was 1.006 (90% CI: 0.851, 1.190). Mean (standard deviation) maximum aripiprazole plasma concentration was 342 (157) ng/ml after the fourth Ari 2MRTU 960 dose and 344 (212) ng/ml after the eighth AOM 400 dose.ConclusionPharmacokinetic parameters were similar between Ari 2MRTU 960 and AOM 400.FundingOtsuka Pharmaceutical Development & Commercialization, Inc. (Princeton, NJ, USA) and H. Lundbeck A/S (Valby, Denmark).
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Zahari, Zarina, Nurul Amira Arnuin, Aslinda Maulat Mohd Fuhad, and Pipeng Lin. "Type of Sitting Posture and Low Back Pain among University Students." Environment-Behaviour Proceedings Journal 8, no. 24 (May 19, 2023): 247–52. http://dx.doi.org/10.21834/ebpj.v8i24.4683.
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Background: Prolonged sitting may cause faulty posture among students leading to low back pain (LBP). Objectives: 1. To compare the time spent sitting among students with and without LBP. 2. To determine the association between types of sitting posture and LBP. Methods: This cross-sectional online survey recruited 420 students. Findings: A majority (56%) of 343 respondents seated >10 hours daily. There was a significant total time spent between students with and without LBP. However, there was no association between types of sitting posture and LBP. Implications: Awareness of avoiding prolonged sitting should be emphasized among the students to minimize LBP. Keywords: Low back pain; Sitting habits; Sitting posture; Sitting time eISSN: 2398-4287 © 2023. The Authors. Published for AMER & cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), and cE-Bs (Centre for Environment-Behaviour Studies), College of Built Environment, Universiti Teknologi MARA, Malaysia DOI: https://doi.org/10.21834/ebpj.v8i24.4683
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Prayitno, Joko. "Penghilangan Senyawa Fenol Oleh Bakteri Yang Diisolasi dari Area Pertambangan Minyak Bumi." Jurnal Teknologi Lingkungan 17, no. 2 (December 20, 2016): 126. http://dx.doi.org/10.29122/jtl.v17i2.1067.
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The aim of this research was to study the effectiveness of local bacterial strains from oil-contaminated soil to degrade phenol. The study consisted of two experiments, using six individual strains and using mix of strains. Bacterial strains used in the first experiment were 1.3, 3.3 dan 8.2.1 (Bacillus sp.), strain 3.2 (Propionibacterium), strain 3.4 (Pseudomonas sp.), and strain 8.1.2 (Enterobacter sp.).Bacterial strains used in the second experiment were mix of all six strains (K6) and mix of three strains (K3) consisted of strain 3.4, 8.1.2 and 8.2.1 with the same ratio. The experiments were conducted in 100 mL Bushnell and Haas medium containing 300-400 ppm phenol for three days.Three strains (strain 3.4, 8.1.2, dan 8.2.1) had the highest phenol removal efficiency at day 3, i.e. 99-100%. COD values were decreased to 345-393 mg/L or 56-61.3% by those three strains. Mix culture K6 effectively removed phenol form the medium, but COD value decreased to only 56.7%. The fate of COD decrease was not the same as phenol removal by these strains (either in idividual or mix cultures), because phenol was degraded into intermediate compounds.
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Keizman, Daniel, Maya Ish-Shalom, Avivit Peer, Maya Gottfried, Hans J. Hammers, Mario A. Eisenberger, Victoria J. Sinibaldi, et al. "Metformin use and outcome of sunitinib treatment in diabetic patients with metastatic renal cell carcinoma." Journal of Clinical Oncology 33, no. 7_suppl (March 1, 2015): 440. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.440.
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440 Background: Sunitinib (Su) is a standard treatment (tx) for metastatic renal cell carcinoma (mRCC). Pre-clinical and clinical studies in several cancer types suggest that the antidiabetic agent metformin (Met) has antitumor activity. Met may negatively regulate mTOR activity. Its effect on the outcome of targeted therapies in mRCC is poorly defined. We analyzed the effect of Met use on the outcome sunitinib tx in diabetic patients (pts) with mRCC. Methods: We performed a retrospective study of an unselected cohort of diabetic pts with mRCC, who were treated with Su in 7 centers across 2 countries. Pts were divided into 2 groups: (1) Met users and (2) Met naive. The effect of Met use on response rate (RR), progression free survival (PFS) and overall survival (OS), was tested with adjustment of other known confounding risk factors using a chisquare test and partial likelihood test from Cox model. Furthermore, univariate and multivariate analyses of association between clinicopathologic factors and Met use, and outcome were performed using the entire pt cohort. Results: Between 2004-2014, 108 diabetic pts with mRCC were treated with sunitinib. There were 52 Met users (group 1) and 56 nonusers (group 2). The groups were balanced regarding the following clinicopathologic factors: age, gender, HENG risk, past nephrectomy, mRCC histology, ≥2 metastatic sites, lung/liver/bone metastasis, prior targeted tx, smoking status, use of angiotensin system inhibitors (ASIs), pre-tx neutrophil to lymphocyte ratio (NLR) >3, Su-induced hypertension (HTN), and Su dose reduction/tx interruption. Clinical benefit (partial response + stable disease) in group 1 vs. group 2 was 96% vs. 84%, while 4% vs. 16% had disease progression within the first 3 months of tx (p=0.054). Median PFS was 15 vs. 11.5 months (p=0.1). Median OS was 32 vs. 21 months (p=0.001). In multivariate analyses of the entire pt cohort (n=108), factors associated with PFS were active smoking (HR=2.7, p<0.0001) and pre-tx NLR >3 (HR 1.8, p=0.012). Factors associated with OS were Met use (HR 0.2, p<0.0001), HENG risk (HR 3.3, p=0.008), active smoking (HR=2.9, p<0.0001), liver metastases (HR 1.8, p=0.004), and pre-tx NLR >3 (HR 3.3, p<0.0001). Conclusions: Met use may improve the OS of diabetic pts with mRCC that are treated with Su.
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Botzki, Alexander, Daniel J. Rigden, Stephan Braun, Masatoshi Nukui, Sunnhild Salmen, Julia Hoechstetter, Günther Bernhardt, Stefan Dove, Mark J. Jedrzejas, and Armin Buschauer. "l-Ascorbic Acid 6-Hexadecanoate, a Potent Hyaluronidase Inhibitor." Journal of Biological Chemistry 279, no. 44 (August 18, 2004): 45990–97. http://dx.doi.org/10.1074/jbc.m406146200.
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Hyaluronidases are enzymes that degrade hyaluronan, an important component of the extracellular matrix. The mammalian hyaluronidases are considered to be involved in many (patho)physiological processes like fertilization, tumor growth, and metastasis. Bacterial hyaluronidases, also termed hyaluronate lyases, contribute to the spreading of microorganisms in tissues. Such roles for hyaluronidases suggest that inhibitors could be useful pharmacological tools. Potent and selective inhibitors are not known to date, althoughl-ascorbic acid has been reported to be a weak inhibitor ofStreptococcus pneumoniaehyaluronate lyase (SpnHL). The x-ray structure of SpnHL complexed withl-ascorbic acid has been elucidated suggesting that additional hydrophobic interactions might increase inhibitory activity. Here we show thatl-ascorbic acid 6-hexadecanoate (Vcpal) is a potent inhibitor of both streptococcal and bovine testicular hyaluronidase (BTH). Vcpal showed strong inhibition ofStreptococcus agalactiaehyaluronate lyase with an IC50of 4 μmand weaker inhibition of SpnHL and BTH with IC50values of 100 and 56 μm, respectively. To date, Vcpal has proved to be one of the most potent inhibitors of hyaluronidase. We also determined the x-ray structure of the SpnHL-Vcpal complex and confirmed the hypothesis that additional hydrophobic interactions with Phe-343, His-399, and Thr-400 in the active site led to increased inhibition. A homology structural model of BTH was also generated to suggest binding modes of Vcpal to this hyaluronidase. The long alkyl chain seemed to interact with an extended, hydrophobic channel formed by mostly conserved amino acids Ala-84, Leu-91, Tyr-93, Tyr-220, and Leu-344 in BTH.
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Tendulkar, Rahul D., Shree Agrawal, Tianming Gao, Jason A. Efstathiou, Thomas M. Pisansky, Jeff M. Michalski, Bridget F. Koontz, et al. "Contemporary Update of a Multi-Institutional Predictive Nomogram for Salvage Radiotherapy After Radical Prostatectomy." Journal of Clinical Oncology 34, no. 30 (October 20, 2016): 3648–54. http://dx.doi.org/10.1200/jco.2016.67.9647.
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Purpose We aimed to update a previously published, multi-institutional nomogram of outcomes for salvage radiotherapy (SRT) following radical prostatectomy (RP) for prostate cancer, including patients treated in the contemporary era. Methods Individual data from node-negative patients with a detectable post-RP prostate-specific antigen (PSA) treated with SRT with or without concurrent androgen-deprivation therapy (ADT) were obtained from 10 academic institutions. Freedom from biochemical failure (FFBF) and distant metastases (DM) rates were estimated, and predictive nomograms were generated. Results Overall, 2,460 patients with a median follow-up of 5 years were included; 599 patients (24%) had a Gleason score (GS) ≤ 6, 1,387 (56%) had a GS of 7, 244 (10%) had a GS of 8, and 230 (9%) had a GS of 9 to 10. There were 1,370 patients (56%) with extraprostatic extension (EPE), 452 (18%) with seminal vesicle invasion (SVI), 1,434 (58%) with positive surgical margins, and 390 (16%) who received ADT (median, 6 months). The median pre-SRT PSA was 0.5 ng/mL (interquartile range, 0.3 to 1.1). The 5-yr FFBF rate was 56% overall, 71% for those with a pre-SRT PSA level of 0.01 to 0.2 ng/mL (n = 441), 63% for those with a PSA of 0.21 to 0.50 ng/mL (n = 822), 54% for those with a PSA of 0.51 to 1.0 ng/mL (n = 533), 43% for those with a PSA of 1.01 to 2.0 ng/mL (n = 341), and 37% for those with a PSA > 2.0 ng/mL (n = 323); P < .001. On multivariable analysis, pre-SRT PSA, GS, EPE, SVI, surgical margins, ADT use, and SRT dose were associated with FFBF. Pre-SRT PSA, GS, SVI, surgical margins, and ADT use were associated with DM, whereas EPE and SRT dose were not. The nomogram concordance indices were 0.68 (FFBF) and 0.74 (DM). Conclusion Early SRT at low PSA levels after RP is associated with improved FFBF and DM rates. Contemporary nomograms can estimate individual patient outcomes after SRT in the modern era.
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Wiryawan, Drajad, Joni Suhartono, Siti Elda Hiererra, and Anderes Gui. "Factors Affecting Digital Banking Customer Satisfaction in Indonesia." International Journal of Application on Sciences, Technology and Engineering 1, no. 1 (February 28, 2023): 335–42. http://dx.doi.org/10.24912/ijaste.v1.i1.335-342.
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This paper aims to determine the factors that influence the satisfaction of using digital banking. The method used is UTAUT (Model Unified Theory of Acceptance and Use of Technology) 2 Modification to help specify variables such as Responsiveness, Usefulness, Ease of Use, History, Access Control, Data Privacy, Assurance, etc. Trust, Quality Transaction, User Intention, and User Satisfaction. This research collects data in a questionnaire distributed to digital banking users through a non-probability sampling method using a data collection technique, namely, snowball sampling. For information, the number of respondents obtained is 410 respondents, of which 56% are male and 44% are female. Further analysis concluded that the various variables significantly affect user satisfaction in using digital banks. For example, the access control variable has a value of 3.453 (on t-statistics), which shows that the access control variable has a significant value among other variables.
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Kuncoro, Sapto, Meinilwita Yulia, and Diding Suhandy. "APLIKASI UV SPECTROSCOPY DAN METODE SIMCA UNTUK KLASIFIKASI KOPI LIBERIKA TUNGKAL JAMBI DAN KOPI LIBERIKA PROBOLINGGO." Jurnal Teknik Pertanian Lampung (Journal of Agricultural Engineering) 10, no. 1 (March 25, 2021): 49. http://dx.doi.org/10.23960/jtep-l.v10i1.49-56.
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Tungkal Composite Jambi Liberika Coffee is one of the top qualities of Indonesian coffees that has received a geographic indication certificate (IGs). With its limited production and high prices, currently Tungkal Jambi Liberika coffee is one of the coffees that is prone to being counterfeited. The counterfeiting of Tungkal Jambi Liberika coffee is increasingly difficult to identify, especially in the form of ground roasted coffee. This study evaluated the potential application of UV spectroscopy technology to classify Tungkal Jambi Liberika coffee (with geographic indications) and normal Probolinggo Liberika coffee (non- geographic indications). A total of 120 samples for each Liberika coffee were prepared weighing 1 gram for each sample. Spectra measurements were carried out in the form of a coffee solution. Spectral data were taken using a UV-visible spectrometer with a wavelength interval of 200-400 nm (Genesys™ 10S UV-Vis, Thermo Scientific, USA). By using the average transformed spectra in the 250-350 nm interval, the differences between the two types of Liberika coffee can be clearly seen, especially at some wavelength peaks, namely 270 nm, 300 nm, 315 nm and 346 nm. The classification accuracy obtained for the SIMCA classification is 100% for both Tungkal Jambi Liberika and Probolinggo Liberika coffee. Keywords: authentication, classification accuracy, Tungkal Jambi Liberika coffee, SIMCA, UV Spectroscopy
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Costa, Eduardo Castro da, João Restle, Fabiano Nunes Vaz, Dari Celetino Alves Filho, Regis Augusto L. Carvalho Bernardes, and Fernando Kuss. "Características da Carcaça de Novilhos Red Angus Superprecoces Abatidos com Diferentes Pesos." Revista Brasileira de Zootecnia 31, no. 1 (February 2002): 119–28. http://dx.doi.org/10.1590/s1516-35982002000100014.
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Foram avaliadas as características quantitativas da carcaça de novilhos Red Angus com idade média inicial de 8 meses e 189 kg, confinados durante 114, 144, 173 e 213 dias até os respectivos pesos de abate (PA) de 340, 370, 400 ou 430 kg, com idade de 12, 13, 14 e 15 meses. A dieta alimentar continha uma relação volumoso:concentrado de 56:44, contendo 13,13% de proteína bruta e 2,7 Mcal de energia digestível/kg MS. O corte serrote, embora tenha aumentado linearmente em peso (91,73; 103,26; 106,20 e 116,66 kg) frente ao aumento do peso de abate, decresceu linearmente quando expresso em relação ao peso de carcaça fria (50,55; 50,79; 50,16; e 48,86%). A porcentagem do corte costilhar foi a que sofreu maior incremento (23,36; 25,40; 28,50; e 35%) com o aumento do peso de abate, acompanhando o aumento na deposição de gordura de cobertura (3,91; 6,16; 6,16; e 9,58 mm). A área do músculo Longissimus dorsi (ALD) aumentou linearmente frente ao aumento do peso de abate (ALD = 27,48 + 0,083PA), enquanto a ALD/100 kg de carcaça fria decresceu linearmente (ALD/100 kg carcaça = 45,14 - 0,0425PA). Foi estimado, por intermédio da equação de regressão, que a espessura de gordura mínima exigida pelos frigoríficos (3 mm) teria sido alcançada com 327 kg de peso. Considerando o peso de carcaça mínimo de 180 kg, este seria atingido com um peso de abate de 337 kg. Utilizando novilhos da raça Red Angus para produção do superprecoce, o peso de abate não deve ser superior a 400 kg, para não exceder os 6 mm de gordura de cobertura, evitando o recorte do excesso.
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Rocha-Loredo, Ana Guadalupe, Neptalí Ramírez-Marcial, and Mario González-Espinosa. "Riqueza y diversidad de árboles del Bosque Estacional Caducifolio en la Depresión Central de Chiapas." Botanical Sciences 87 (December 1, 2010): 89. http://dx.doi.org/10.17129/botsci.313.
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<p>Se evaluó la diversidad de árboles contenida en 96 parcelas circulares de 0.1 ha, distribuidas en un intervalo altitudinal entre 441 y 1,740 m en la Depresión Central de Chiapas. Las parcelas se clasificaron mediante un análisis de agrupamiento jerárquico y se ordenaron a lo largo de un gradiente ambiental por medio de un análisis de escalamiento multidimensional no métrico (NMDS). La clasificación permitió reconocer cinco asociaciones vegetales, tres de ellas correspondientes al bosque tropical caducifolio (BTC) y dos a los bosques de Quercus. La riqueza regional está representada por un total de 233 especies, en 152 géneros y 57 familias botánicas. La contribución de las parcelas a la diversidad total fue mayor en las asociaciones del bosque tropical caducifolio que en las de Quercus. La composición de especies estuvo dominada por individuos de etapas sucesionales tardías en las asociaciones del BTC (40-56%), en tanto que en los bosques de Quercus la mayor contribución fue de especies secundarias<br /> (46-54%). La ordenación (NMDS) mostró una relación significativa de las parcelas con 10 de 12 variables climáticas, de las cuales el promedio anual de la temperatura media del mes más caliente (r2 = 0.74, P <0.001) y la precipitación media anual (r2 = 0.85, P<0.001) fueron las más importantes. A pesar de que en la Depresión Central de Chiapas persiste menos del 2% de la cobertura forestal, la diversidad de árboles es relativamente alta, debido a la heterogeneidad ambiental que promueve el recambio de especies a nivel regional.</p>
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Raya-Santos, C., J. Rosas, M. Marco, A. Pons, J. C. Cortés-Quiroz, M. Shalabi, J. M. Senabre-Gallego, et al. "POS0369 IMPACT OF HYDROXYCHLOROQUINE LEVEL ON ECG QTC INTERVAL IN PATIENTS WITH RHEUMATIC SYSTEMIC AUTOIMMUNE DISEASES: A REAL-LIFE STUDY." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 438.2–438. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4046.
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ObjectivesTo analyze the impact of the serum level of hydroxychlroquine (OHCLQ) on the QTc interval of the ECG, in patients with rheumatic systemic autoimmune diseases (SARD), treated with this drug for a long timeMethodsRetrospective study, among patients with SARD, treated with OHCLQ ≥ 1 year, dose 200-400 mg/day. Serum OHCLQ level was measured by liquid chromatography and QTc interval by ECG (Welch Allyn 200; SF, N York, USA). Two control groups for QTc are included: Group-1: patients with SARD not treated with OHCQ; Group-2: healthy subjects without SARD. In both, weight and current treatment and an ECG were recorded.In patients with SARD was collected: 1) Epidemiological data: age, sex, weight, concomitant diseases, current treatment. 2) SARD: diagnosis, year of diagnosis, disease evolution time, clinical and autoimmunity data, treatment and dose. 3) OHCLQ: time in treatment, toxicity, symptoms (dizziness, syncope) and serum level. 4) ECG; QTc and heart rate (HR).Results65 patients treated with OHCLQ, mean 10.8 (6.5) years are included, diagnosed with SLE: 43 (66%) patients, RA: 15 (23%), palindromic rheumatism: 4 (6%), SS1º: 2 (3 %) and PsA: 1 (1%). 63 (97%) patients are women, with a mean age (SD): 58 (14.7) years, weight: 69 (15) kg. Mean dose of OHCLQ: 221 mcg/L (64), 3.24 (1) mg/kg/day.Mean serum OHCLQ level: 166 mcg/L (6.5): 18 (28%) patients with level <100 mcg/L (mean: 63 [0.7] mcg/L) and 47 (72%) with level >100 mcg/L L (mean 195 mg/XX [94]). On ECG, mean HR: 69 bpm (10) and mean QTc interval: 429.7 (84) ms, prolonged (>440 ms) in 23 (35%) of the patients.12 (18%) patients reported dizziness at some time and 29 (45%) were being treated with a drug related to the risk of QTc prolongation: Possible (P: at authorized doses no risk of TdP): 1 (2%) patient, Conditional (C: risk under excessive dose, interactions): 13 (20%), P+C: 4 (8%), C+C: 11 (17%).When comparing the mean QTc result of the group with OHCLQ and the control groups without OHCLQ (n: 41), the QTc is higher (p=0.062) than the group of healthy subjects (n: 23) and without differences with the control group EASR (n: 18), not treated with OHCLQ (p=0.70). Among patients with OHCLQ level >100 mcg/L (n: 47) vs <100 mcg/L (n: 18), patient weight (p=0.012), level (p<0.0001), and dose in mg /kg (p=0.03), is significantly higher at levels >100 mcg/L. No relationship was observed between the OHCLQ level and the QTc result.In 6 (9%) patients the OHCLQ dose is >3 mg/kg (mean: 5.35 [1] mg/kg, HR: 73 [14] bpm, OHCLQ dose: 367 [71] mcg/L), no detected significant differences in QTc (1 patient presented QTC >440). In patients with QTc >440 ms, older patient age, QTc result, and heart rate were significant. However, the dose in mg/kg of OHCLQ was lower in the group with QTc <440 ms (p=007).ConclusionIn patients with SARD treated with maintenance doses of OHCLQ of about 3 mg/kg/day, 1) The serum level of OHCLQ is not associated with QTc prolongation on the ECG. 2) QTc is significantly related to age and heart rate. 3) The EASR per se does not affect the QTc result.Table 1.Characteristics of patients with QTc greater than or less than 440 ms and with an OHCLQ level greater than or less than 100 mcg/L.QTc >440 ms N: 23 (35%)QTc ≤440 ms N: 42 (65%)pAge, mean (SD)64 (15)56 (14.5)0.007Female, n (%)22 (96)40 (95)0.85QTc, mean (SD)454 (23.9)416 (23.7)0.0001Symptoms, n (%)4 (17)4 (10)0.77Heart rate, mean (SD)74 (10.3)67 (10.3)0.016Weight, mean (SD)69 (15.1)67 (15.6)0.61Risk factors QTc prolongation Concomitant disease, n (%)4 (17)4 (10)0.77 Drugs, n (%)14 (61)15 (36)0.18OHCLQ;Dosis, mean (SD)209 (64.5)229 (15.8)0.15Mg/kg OHCLQ, media (SD)2.91 (1.06)3.43 (1.08)0.07Years in treatment, mean (SD)9.3 (6.6)10.5 (6.5)0.48OHCLQ serum level, media (SD)174.27 (94.6)162,4 (80)0.51OHCLQ >100 mcg/LOHCLQ ≤100 mcg/LN: 47 (72%)N: 18 (28%)pOHCLQ serum level, mean (SD)166 (94)63 (96.5)0.0001QTc, mean (SD)430 (24)431 (23)0.87Dosis mg, mean (SD)221 (65)208 (66.5)0.48Mg/kg OHCLQ, mean (SD)3.32 (1.1)2.65 (1.08)0.03Years in OHCLQ, mean (SD)10.8 (6.8)11.5 (6.9)0.71Weight, mean (SD)69 (15.3)80 (15.2)0.012AcknowledgementsEl estudio fue apoyado con una beca de investigación de la Asociación para la Investigación en Reumatología de la Marina Baixa (AIRE-MB).Disclosure of InterestsNone declared
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Solomon, Benjamin J., Federico Cappuzzo, Enriqueta Felip, Fiona H. Blackhall, Daniel B. Costa, Dong-Wan Kim, Kazuhiko Nakagawa, et al. "Intracranial Efficacy of Crizotinib Versus Chemotherapy in Patients With Advanced ALK-Positive Non–Small-Cell Lung Cancer: Results From PROFILE 1014." Journal of Clinical Oncology 34, no. 24 (August 20, 2016): 2858–65. http://dx.doi.org/10.1200/jco.2015.63.5888.
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Purpose Intracranial efficacy of first-line crizotinib versus chemotherapy was compared prospectively in the phase III PROFILE 1014 study in ALK-positive non–small-cell lung cancer. Patients and Methods Patients were randomly assigned to receive crizotinib (250 mg twice daily; n = 172) or chemotherapy (pemetrexed 500 mg/m2 plus cisplatin 75 mg/m2 or carboplatin at area under the curve 5 to 6, every 3 weeks for ≤ six cycles; n = 171). Patients with stable treated brain metastases (tBM) were eligible. Intracranial efficacy was assessed at baseline and every 6 or 12 weeks in patients with or without known brain metastases (BM), respectively; intracranial time to tumor progression (IC-TTP; per protocol) and intracranial disease control rate (IC-DCR; post hoc) were measured. The intent-to-treat population was also assessed. Results Of 343 patients in the intent-to-treat population, 23% had tBM at baseline. A nonsignificant IC-TTP improvement was observed with crizotinib in the intent-to-treat population (hazard ratio [HR], 0.60; P = .069), patients with tBM (HR, 0.45; P = .063), and patients without BM (HR, 0.69; P = .323). Among patients with tBM, IC-DCR was significantly higher with crizotinib versus chemotherapy at 12 weeks (85% v 45%, respectively; P < .001) and 24 weeks (56% v 25%, respectively; P = .006). Progression-free survival was significantly longer with crizotinib versus chemotherapy in both subgroups (tBM present: HR, 0.40; P < .001; median, 9.0 v 4.0 months, respectively; BM absent: HR, 0.51; P < .001; median, 11.1 v 7.2 months, respectively) and in the intent-to-treat population (HR, 0.45; P < .001; median, 10.9 v 7.0 months, respectively). Conclusion Compared with chemotherapy, crizotinib demonstrated a significantly higher IC-DCR in patients with tBM. Improvements in IC-TTP were not statistically significant in patients with or without tBM, although sensitivity to detect treatment differences in or between the two subgroups was low.
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Chen, Yen Chang, and Yung Ning Pan. "Effects of Grain Size and Rotational Speed on the Bio-Oil Yield in a Fast Pyrolysis Reactor Employing a Single Tapered Screw Extruder." Advanced Materials Research 347-353 (October 2011): 153–56. http://dx.doi.org/10.4028/www.scientific.net/amr.347-353.153.
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The effects of process parameters of biomass grain size (ranging from 0.425 to 3.35mm), rotational speed (ranging from 20 to 60rpm) and the pyrolysis temperature (ranging from 400 to 550 oC) on the yield of bio-oil were investigated in this study by using a fast pyrolysis reactor with a single tapered screw extruder. This study gives the optimal pyrolysis temperatures and rotational speeds for different grain sizes to achieve peak bio-oil yield. The results indicate that higher feed rates are required for larger grain sizes to achieve peak bio-oil yields. For instance, a 20rpm rotational speed is for 0.425~1.18mm grain sizes (50~57% bio-oil yield), while a 40rpm rotational speed is for 1.7~3.35mm grain sizes (56~60% bio-oil yield). This implies that the productivity of bio-oil can be significantly increased in the current system. For the case of 2.5~3.35mm grain size, which corresponds to an optimal rotational speed of 40rpm, the production rate was estimated to be around 4kg/h.
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Sreejamol, MG, R. Radhika, and Rajalakshmi Reghuvaran. "Selfitis: An Analysis on Prevalence and Attitude among College Students." Indian Journal of Psychiatric Nursing 20, no. 2 (2023): 133–36. http://dx.doi.org/10.4103/iopn.iopn_49_22.
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Abstract Introduction: Our daily lives now mostly revolve around our smartphones. Due to the widespread use of mobile phones, selfies have become the newest technical trend among young people. The most common practice of taking selfies in dangerous situations is proving to be a fatal one. The majority of these fatalities and injuries are from falls from great heights and posing with dangerous objects. Objective of the Study: The objective of this study was to assess the attitude and prevalence of selfitis among college students. Methodology: Descriptive design was used in this study. Convenience sampling technique was used to select 400 college students from a technical college of Ernakulam district, Kerala, within the age group of 16–24 years. The data were collected using two semi-structured questionnaires and Solanki Selfie Addiction Scale, a standardized tool for the assessment of selfie addiction. Results: It was found that 86% (344) were males and 14% (56) were females. Eighty-five percentage (340) of the study subjects had smartphone and only a few, 60 (15%) were not using it. About 59.5% (238) of them used all the enlisted social media. The prevalence of selfie addiction shows majority, 260 (65%) had mild selfie addiction, 76 (19%) had no selfie addiction but few had moderate 64 (16%) selfie addiction, and there was no severe selfie addiction. Result of attitude shows that 82% (328) have a neutral attitude, 16% (64) shows a positive attitude, and 2% (8) shows a negative attitude toward selfie. Conclusion: The result highlights the importance of providing education regarding the healthy use of social media.
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Costa, Eduardo Castro da, João Restle, Leonir Luiz Pascoal, Fabiano Nunes Vaz, Dari Celestino Alves Filho, and Miguelangelo Ziegler Arboitte. "Desempenho de Novilhos Red Angus Superprecoces, Confinados e Abatidos com Diferentes Pesos." Revista Brasileira de Zootecnia 31, no. 1 (February 2002): 129–38. http://dx.doi.org/10.1590/s1516-35982002000100015.
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Foi avaliado o desempenho em confinamento de machos Red Angus confinados a partir dos oito meses de idade, quando apresentavam peso vivo médio de 189 kg, até atingirem os seguintes pesos pré-determinados (PA): 340, 370, 400 e 430 kg. O número de dias necessários para atingir os respectivos pesos foram de 114, 144, 168 e 209 dias, com 12, 13, 14 e 15 meses de idade. Os animais foram alimentados com uma dieta contendo 13,13% de proteína bruta e relação volumoso (silagem de milho):concentrado de 56:44. O ganho de peso médio diário foi de 1,32; 1,27; 1,23; e 1,15 kg respectivamente. O consumo médio diário de matéria seca (CMS), expresso em kg/dia/animal e por peso metabólico, não apresentou relação significativa com o peso de abate. Quando o CMS foi expresso por 100 kg de peso vivo, houve queda linear (CMS/100 kg PV= 3,599 - 0,003152PA) em relação ao aumento do peso de abate. O estado corporal melhorou linearmente com o aumento do peso de abate (ECF= 0,159 + 0,0103PA), enquanto a conversão alimentar piorou (CAMS= 1,585 + 0,01019PA), porém a mesma pode ser considerada muito boa, sendo, respectivamente, de 5,09; 5,35; 5,55; e 6,04 kg de MS/kg de ganho de peso. Foi estimado, por intermédio da equação de regressão, que, para atender o peso de carcaça e a gordura de cobertura mínimos exigidos, o peso de abate deveria ser de 337 e 327 kg, respectivamente.
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Feng, Yu Hong, Jia Cheng Li, Qiang Lin, Xi Bin Wang, Zhou Xin Wu, Su Juan Pang, and Zhong Liang Sun. "Crystallinity and Thermal Decomposition of Dialdehyde Celluloses from Bacterial Cellulose." Key Engineering Materials 330-332 (February 2007): 1289–92. http://dx.doi.org/10.4028/www.scientific.net/kem.330-332.1289.
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A series of dialdehyde cellulose samples with varied aldehyde content were prepared by oxidation of bacterial cellulose with sodium periodate. The X-ray diffractometry profile showed that the crystallinity degree of bacterial cellulose was 66%, but that of the dialdehyde cellulose (containing 12% aldehyde ) was 56%. Thermal decomposition of these dialdehyde cellulose samples and bacterial cellulose were studied by thermogravimetry. The decomposition of bacterial cellulose in nitrogen started at 230 and rapid weight loss occurred between 300-400. The introduction of dialdehyde group to bacterial cellulose resulted in significant shifts of decomposition to lower temperature range. The decomposition of dialdehyde cellulose (12% aldehyde ) started at 180 and rapid weight loss between 200-350. The temperature of rapidest weight loss shifted from 340 of bacterial cellulose to 290 of the dialdehyde cellulose(12% aldehyde).
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Neciosup, Silvia P., Jose Quesada, David Callacondo, and Ivan Aguilar. "Prevalence of testicular microlithiasis association with testicular and extragonadal germ cell tumors in a Latin American population." Journal of Clinical Oncology 30, no. 5_suppl (February 10, 2012): 331. http://dx.doi.org/10.1200/jco.2012.30.5_suppl.331.
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331 Background: Testicular microlithiasis (TM) is a entity characterized by multiple areas of increased echogenicity on scrotal ultrasonography (U.S.). Studies have reported association between TM and testicular germ cell tumors (TGCT). However, a study assessing the association of TM and extragonadal germ cell tumors (EGCT) has not been performed. Methods: Scrotal U.S. were reviewed in 441 men randomly selected from our computerized database during the period 1998 and 2010 at our tertiary-care cancer hospital. The association of U.S. findings with medical records and a history of germ cell tumors (GCT) were evaluated. The type of tumor was confirmed at histology after surgery or biopsy. Exclusion criteria included age <15 years and history of orchidectomy. Results: The median age was 32 years (range 15 – 88). TM was present in 95 patients (22%) and GCT were found in 130 patients (29%). 105 of these had TGCT (seminoma, n=56 and no seminoma, n=49) and 25 had EGCT (mediastinal, n=16, retroperitoneal, n=6 and CNS, n=3). Concurrent diagnosis of a TGCT was more prevalent in TM patients than in patients without TM (36/95 [38%] versus 69/346[20%] OR 2.45 95% CI 1.49–4.0; p<0.0001) while a diagnosis of an EGCT was present in 13 patients with TM and 12 patient without TM (13/95 [14%] versus 12/346 [3%] OR 4.41 95% CI 1.94–10.03; p<0.0001). No statistical differences were found for histology type. Conclusions: The prevalence in Latin American of TM is higher than previous reports and strongly associated with TCGT and EGCT. The clinical impact of the relationship between EGCT and TM is yet unknown and further studies are needed to clarify its role in the management. We suggest that young high-risk referral patients with TM should undergo scrotal U.S. annually; when a testicular tumor is not evident by U.S., investigations to rule out an EGCT, as thoracic or abdominal CT scans, should be considered individually in each case.
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Bauer, A. G. C., J. H. P. Wilson, S. W. J. Lamberts, R. Docter, G. Hennemann, and T. J. Visser. "Handling of iodothyronines by the liver and kidney in patients with chronic liver disease." Acta Endocrinologica 116, no. 3 (November 1987): 339–46. http://dx.doi.org/10.1530/acta.0.1160339.
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Abstract. Possible arterio-venous gradients of T4, T3, rT3 and 3,3'-diiodothyronine (3,3'-T2) across the liver and the kidneys were measured in 9 patients with varying degrees of liver failure undergoing diagnostic catheterization. Plasma iodothyronine levels were measured in peripheral, hepatic and renal veins before and at 10-min intervals until 60 min after iv injection of 400 μg of TRH. In 2 patients estimated hepatic plasma flow and effective renal plasma flow were determined as well. In these 2 patients, no significant differences between iodothyronine levels in arterial and peripheral venous plasma were found. T4 and T3 levels were not significantly different between peripheral, renal and hepatic veins. Hepatic vein rT3 and 3,3'-T2 concentrations were 10.7 ± 8.3% (mean ± sd, P < 0.005) and 36 ± 18% (P < 0.001) lower than those in the peripheral vein (N = 9). Renal vein rT3 was just (6.2 ± 7.5%, P < 0.05) lower than rT3 in peripheral vein, whereas 3,3'-T2 was not different between the two veins. Estimates of hepatic and renal plasma flow were in agreement with values from the literature. On the basis of these data approximate hepatic clearance rates of 110 and 380 1/day for rT3 and 3,3'-T2 and a renal clearance rate of about 35 1/day for rT3 were calculated. Sixty min after TRH, plasma T3 was increased to 147 ± 56% (P < 0.05) and 3,3'-T2 in peripheral plasma was increased to 142 ± 36% (P < 0.025), whereas plasma T4 and rT3 did not change. These data suggest that the liver is the major site of plasma rT3 and 3,3'-T2 clearance in patients with mild liver disease and probably also in healthy humans. The kidneys may account for roughly 25% of plasma rT3 clearance. The increase in plasma 3,3'-T2 after TRH may be secondary to the rise in precursor T3, but thyroidal secretion of 3,3'-T2 is not excluded.
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Rogachev, S. O., E. A. Naumova, R. D. Karelin, V. A. Andreev, M. M. Perkas, V. S. Yusupov, and V. M. Khatkevich. "Structure and mechanical properties of Al–Ca–Mn–Fe– Zr–Sc eutectic aluminum alloy after equal channel angular pressing." Izvestiya Vuzov. Tsvetnaya Metallurgiya (Universities' Proceedings Non-Ferrous Metallurgy) 27, no. 2 (April 19, 2021): 56–65. http://dx.doi.org/10.17073/0021-3438-2021-2-56-65.
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Multicomponent eutectic alloys developed in recent years based on the Al–Ca system have high practical application prospects due to their low density, high corrosion resistance, good processability when casting, and high formability in the as-annealed state. Alloy hardening is achieved by doping with Mn, Fe, Zr, Sc and other elements. Obtaining an ultrafine-grained state in aluminum alloys by the methods of severe plastic deformations, e.g. equal channel angular pressing (ECAP), significantly increases the complex of their mechanical properties. In this regard, the purpose this paper was aimed to study the effect of warm ECAP on the structure, mechanical properties and thermal stability of the eutectic aluminum alloy, wt.%: Al–3.5Ca–0.9Mn–0.5Fe–0.1Zr–0.1Sc. The ECAP process was carried out on as-cast alloy specimens with a diameter of 20 mm (temperature 400 °C, route BC, channel intersection angle 110°, number of passes N = 6). It is shown that as a result of ECAP, a developed substructure with high-density dislocations and released nanosized Al6(Mn, Fe), and Al3Sc particles is formed in the alloy, as well as primary coarse Al6(Mn, Fe) particles and eutectic Al4Ca particles are reduced in size. Such a change in the structure during ECAP leads to the significant hardening of the alloy: its strength properties increased by 1.5–2.0 times, and relative elongation decreased by 1.3 times in the longitudinal section sample and slightly changed in the «transverse» section sample as compared to the initial condition.
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Djordjevic, Mladen, Tzenko Vatchev, Zdenka Girek, Milan Sevic, Bogoljub Zecevic, Jasmina Zdravkovic, and Mirko Ivanovic. "Reaction of different tomato cultivars toward race 1 of Fusarium oxysporum f. sp. lycopersici." Genetika 44, no. 1 (2012): 109–18. http://dx.doi.org/10.2298/gensr1201109d.
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The aim of this study was to examine the reaction of different tomato cultivars towards race 1 of Fusarium oxysporum f. sp. lycopersici. The researched tomato cultivars were: Adonis, Gruzanski zlatni, Jasmin crveni, Narvik SPF and SP109, breeding lines Hom-3, Hom-4, L-4, S-49, S-31, S- 35, SPA, SPR,V-100, 34/56, 93/10 and 93/16. Reaction to pathogen were tested in F1 generation, as well, in combination of 93/16 x V-100, S-35 x L- 4, S-49 x SPA, 34/56 x SPR, S-49 x Hom-4, 93/16 x Hom-3 and 93/10 x S- 31. Plants were inoculated by submerging wounded roots in to pathogen suspension. Disease was assessed 30 days after inoculation. After evaluation 15 cultivars expressed resistance toward this pathogen. Among them 93/10 x S-31, Hom-3 and 93/10 had average disease rating 1,0. Other genotypes had average disease ratings as follows: Narvik SPF and S-49 (1,1), 34/56, Hom-4 and S-49 x Hom-4 (1,2), while Adonis, 93/16 x Hom-3, 34/56 x SPR and 93/16 x V-100 had average disease rating 1,3. Cultivars SPR and 93/16 had 1,7 ADR, meanwhile Sp-109 had 1,8 average rating. Genotypes SPA (2,1), S-49 x SPA (2,1), V-100 (2,2) and L-4 (2,6) belong to the group of tolerant genotypes who did not expressed typical symptoms of chlorosis and wilt of plant but expressed some level of necrosis of xylem in lower part of plants. Most sensitive to fusarium wilt were S-35 x L-4 (3,3), S-35 (3,5), S-31 (3,6), Gruzanski zlatni (3,8) and Jasmin Crveni with average disease rating of 4,0.
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Gorlov, L. E., M. V. Glavatskikh, R. Yu Barkov, and A. V. Pozdniakov. "Mechanical properties and electrical conductivity of Al–Y–Sс–Er cold worked alloy." Izvestiya. Non-Ferrous Metallurgy, no. 2 (April 25, 2023): 49–56. http://dx.doi.org/10.17073/0021-3438-2023-2-49-56.
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Aluminum alloys alloyed with rare earth and transition metal are promising materials for electric energy transportation due to their high properties of strength, thermal stability, and electrical conductivity. The features of strengthening, their mechanical properties and electrical conductivity of Al–0.2Y–0.2Sc–0.3Er alloy after cold rolling have been established. The alloy as a cast structure is presented by aluminum solid solution (Al) and dispersed eutectics with τ2 (Al75-76Er11-17Y7-14) phase upon complete dissolution of scandium in (Al), and a content of yttrium and erbium at the level of 0.2–0.3 % each. Cold rolling the ingot accelerates strengthening upon annealing at 270 and 300 °C, reducing the time of achieving peak hardness. The maximum strengthening due to precipitation of L12 dispersoid of Al3(Sc,Y,Er) phase with the average particle size up to 10 nm is achieved after 7 h of annealing at 300 °C after cold rolling. This shows the prevailing heterogeneous mechanism of nucleation due to defects accumulated during cold rolling which stimulates strengthening. The eutectic particles are located mainly along the boundaries, elongated in the rolling direction. Irrespective of the mode of sheet fabrication, the alloy demonstrates high thermal stability up to 400 °C. During annealing of the sheets to 450 °C, their non-recrystallized structure is retained. Ingot annealing at t = 300 °C in 7 h and cold rolling with subsequent annealing under the same conditions provide a high level of mechanical properties and electrical conductivity: σ0.2 = 194 MPa, σu = 210 MPa, δ = 12.1 % and IACS – 60,1 %. The alloy has demonstrated high yield stress up to 100 h of annealing at t = 300 °C.
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Flück, Daniela, Laura E. Morris, Shailesh Niroula, Christine M. Tallon, Kami T. Sherpa, Mike Stembridge, Philip N. Ainslie, and Ali M. McManus. "UBC-Nepal expedition: markedly lower cerebral blood flow in high-altitude Sherpa children compared with children residing at sea level." Journal of Applied Physiology 123, no. 4 (October 1, 2017): 1003–10. http://dx.doi.org/10.1152/japplphysiol.00292.2017.
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Developmental cerebral hemodynamic adaptations to chronic high-altitude exposure, such as in the Sherpa population, are largely unknown. To examine hemodynamic adaptations in the developing human brain, we assessed common carotid (CCA), internal carotid (ICA), and vertebral artery (VA) flow and middle cerebral artery (MCA) velocity in 25 (9.6 ± 1.0 yr old, 129 ± 9 cm, 27 ± 8 kg, 14 girls) Sherpa children (3,800 m, Nepal) and 25 (9.9 ± 0.7 yr old, 143 ± 7 cm, 34 ± 6 kg, 14 girls) age-matched sea level children (344 m, Canada) during supine rest. Resting gas exchange, blood pressure, oxygen saturation and heart rate were assessed. Despite comparable age, height and weight were lower (both P < 0.01) in Sherpa compared with sea level children. Mean arterial pressure, heart rate, and ventilation were similar, whereas oxygen saturation (95 ± 2 vs. 99 ± 1%, P < 0.01) and end-tidal Pco2 (24 ± 3 vs. 36 ± 3 Torr, P < 0.01) were lower in Sherpa children. Global cerebral blood flow was ∼30% lower in Sherpa compared with sea level children. This was reflected in a lower ICA flow (283 ± 108 vs. 333 ± 56 ml/min, P = 0.05), VA flow (78 ± 26 vs. 118 ± 35 ml/min, P < 0.05), and MCA velocity (72 ± 14 vs. 88 ± 14 cm/s, P < 0.01). CCA flow was similar between Sherpa and sea level children (425 ± 92 vs. 441 ± 81 ml/min, P = 0.52). Scaling flow and oxygen uptake for differences in vessel diameter and body size, respectively, led to the same findings. A lower cerebral blood flow in Sherpa children may reflect specific cerebral hemodynamic adaptations to chronic hypoxia. NEW & NOTEWORTHY Cerebral blood flow is lower in Sherpa children compared with children residing at sea level; this may reflect a cerebral hemodynamic pattern, potentially due to adaptation to a hypoxic environment.
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Fry, R. "200 THE USE OF LONG-ACTING FSH-MAP5 IN SHEEP SUPEROVULATION PROGRAMS." Reproduction, Fertility and Development 29, no. 1 (2017): 208. http://dx.doi.org/10.1071/rdv29n1ab200.
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The administration of sustained-release FSH-MAP5 in a 2-injection protocol has been shown to be as effective as a multiple-FSH injection protocol in inducing superovulation in cattle (Bo and Mapletoft 2014 Theriogenology 81, 38) and in sheep (Fry et al. 2016 Reprod. Fertil. Dev. 28, 250); however, the effect on embryo quality in the latter experiment was unclear. The following experiment further investigated the effect of FSH-MAP5 on ovulation rate and embryo quality in a sheep multiple-ovulation embryo transfer (MOET) program conducted in the breeding season. Two hundred sixteen Dohne merino ewes received a 12-day CIDR-S device containing 0.33 g of progesterone (Zoetis, Florham Park, NJ, USA) plus 200 mg of FSH IM (Folltropin-V; Vetoquinol, Belleville, Canada) and 400 IU of eCG IM (Pregnecol: Vetoquinol) in 4 treatment groups. Group 1 (n = 51) received 7 injections (a.m., p.m.) of FSH in saline (2.5, 2.0, 1.5, 1.5, 1.0, 1.0, and 0.5 mL) starting 2.5 days before CIDR withdrawal and 400 IU of eCG in saline at the time of the first FSH injection. Group 2 (n = 53) received 6 injections (a.m., p.m.) of FSH in saline (3.0, 2.0, 1.5, 1.5, 1.0, and 1.0 mL) starting 2.5 days before CIDR withdrawal and 400 IU of eCG in saline at CIDR withdrawal. Group 3 (n = 56) received 3.3 mL of FSH in hyaluronan (50 mg of MAP5, Vetoquinol) and 400 IU of eCG in saline 2.5 days before CIDR withdrawal and 1.7 mL of FSH-MAP5 at 0.5 days before CIDR withdrawal. Group 4 (n = 56) received 3.3 mL of FSH-MAP5 at 2.5 days before CIDR withdrawal, 1.7 mL of FSH-MAP5 at 0.5 days before CIDR withdrawal, and 400 IU of eCG in saline at CIDR withdrawal. Ewes were inseminated with semen collected and pooled from 5 rams at 36 to 40 h after CIDR withdrawal. Donor ewes were slaughtered 6 days after AI, corpora lutea were counted on the ovary, and ova/embryos were collected. Data for corpora lutea, total ova/embryo, and transferable embryo was analysed by the Kruskal–Wallis test and differences between groups were determined by the Dunn’s test. Results are shown in Table 1. There were no differences in the mean number of ovulations or total ova/embryo collected between any group (P > 0.05); however, those receiving eCG at the time of CIDR withdrawal (Groups 2 and 4) had significantly more transferable embryos than those receiving eCG at the time of the first FSH injection (Groups 1 and 3). In conclusion, the administration of the sustained-release FSH-MAP5 in a 2-injection protocol in sheep was as effective as a multiple-FSH injection protocol in inducing multiple ovulations and yielded similar number of transferable embryos, whereas the administration of eCG at the time of CIDR withdrawal resulted in more transferable embryos, possibly by improving fertilisation rates. Table 1. Results1
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Aquino, Leonardo A. de, Mário Puiatti, Paulo RG Pereira, Francisco HF Pereira, Igor R. Ladeira, and Mariana RS Castro. "Produtividade, qualidade e estado nutricional da beterraba de mesa em função de doses de nitrogênio." Horticultura Brasileira 24, no. 2 (June 2006): 199–203. http://dx.doi.org/10.1590/s0102-05362006000200015.
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O N é fundamental para a produtividade e a qualidade das hortaliças, todavia há carência de informações sobre seu uso em beterraba de mesa. Neste trabalho objetivou-se avaliar a produtividade, a qualidade e o estado nutricional nitrogenado da beterraba em função do N aplicado. Foram utilizadas quatro doses de N (0; 100; 200 e 400 kg ha-1de N), no delineamento blocos casualizados, com quatro repetições. Aos 28 dias após o transplante (dat), avaliou-se o estado nutricional nitrogenado por meio do teor de N-NO-3 nas folhas e clorofilômetro (SPAD). Na colheita (56 dat), foram avaliados: área foliar, produção de massas fresca (MF) e seca (MS) e teores de N-NO-3 e N-total nas folhas e raizes tuberosas e de sólidos solúveis totais nas raizes tuberosas. Com o incremento das doses de N, observaram-se aumentos para todas as características avaliadas. Aos 28 dias após o transplantio, o teor de N-NO-3 e unidades SPAD, correspondentes a 95% da produção máxima foram, respectivamente, de 2.575 mg kg-1 de MS e 44,7 unidades SPAD. Considerando-se apenas os aspectos quantitativo e econômico da produtividade de raizes, a dose de máxima eficiência econômica é de 343 kg ha-1 de N; todavia, ao serem considerados os aspectos quantitativo e qualitativo, a dose recomendada é de 193 kg ha-1 de N.
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Kräuter, Marianne, Taher Abu Ali, Barbara Stadlober, Roland Resel, Katrin Unger, and Anna Maria Coclite. "Tuning the Porosity of Piezoelectric Zinc Oxide Thin Films Obtained from Molecular Layer-Deposited “Zincones”." Materials 15, no. 19 (September 30, 2022): 6786. http://dx.doi.org/10.3390/ma15196786.
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Porous zinc oxide (ZnO) thin films were synthesized via the calcination of molecular layer-deposited (MLD) “zincone” layers. The effect of the MLD process temperature (110 °C, 125 °C) and of the calcination temperature (340 °C, 400 °C, 500 °C) on the chemical, morphological, and crystallographic properties of the resulting ZnO was thoroughly investigated. Spectroscopic ellipsometry reveals that the thickness of the calcinated layers depends on the MLD temperature, resulting in 38–43% and 52–56% of remaining thickness for the 110 °C and 125 °C samples, respectively. Ellipsometric porosimetry shows that the open porosity of the ZnO thin films depends on the calcination temperature as well as on the MLD process temperature. The maximum open porosity of ZnO derived from zincone deposited at 110 °C ranges from 14.5% to 24%, rising with increasing calcination temperature. Compared with the 110 °C samples, the ZnO obtained from 125 °C zincone yields a higher porosity for low calcination temperatures, namely 18% for calcination at 340 °C; and up to 24% for calcination at 500 °C. Additionally, the porous ZnO thin films were subjected to piezoelectric measurements. The piezoelectric coefficient, d33, was determined to be 2.8 pC/N, demonstrating the potential of the porous ZnO as an, e.g., piezoelectric sensor or energy harvester.
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Tosoian, Jeffrey J., Simpa Samuel Salami, Srinivas Nallandhighal, Tonye A. Jones, Komal R. Plouffe, Fuad F. Elkhoury, Todd Matthew Morgan, et al. "Molecular characterization of longitudinally tracked prostate cancer foci in men on active surveillance for low-risk disease." Journal of Clinical Oncology 37, no. 7_suppl (March 1, 2019): 56. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.56.
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56 Background: The biological trajectory of Gleason score 6 (GS6) prostate cancer (PCa) in men on active surveillance (AS) is unknown. We herein evaluate the potential for high grade PCa to arise clonally from GS 6 disease and determine the capacity of tissue-based biomarkers to predict grade progression. Methods: Men on AS with GS6 PCa who underwent magnetic resonance imaging/ultrasound (MRI/US) fusion biopsy on two occasions from 2012 through 2017 were enrolled. Tumor foci were tracked and re-sampled using the MRI/US fusion biopsy platform. ERG immunohistochemistry (IHC) and DNA/RNA next generation sequencing (NGS) were performed on formalin-fixed paraffin-embedded (FFPE) initial and repeat biopsy specimens to assess tumor clonality and evaluate candidate molecular markers of PCa grade progression. Results: Sixty-seven men of median age 64 years (IQR 59-69) and PSA 4.9 ng/ml (IQR 3.3-6.4) underwent repeat sampling of a single tracked tumor focus using MRI/US fusion biopsy. The median interval to repeat biopsy was 11 months (IQR 6-13). On repeat biopsy, 31 (46%) men progressed to high-grade (GS≥7) disease (n = 24, GS 3+4 = 7; n = 7, GS ≥4+3 = 7). Among the 67 subjects, ERG IHC status was concordant between initial and repeat biopsy in 64 (96%). Of 134 total specimens obtained (67 initial + 67 repeat biopsies), ERG status determined by NGS was concordant with ERG status by IHC in 132 (99%). Comparing the initial biopsy specimens in men who did versus did not undergo grade progression on follow up biopsy, derived cell cycle progression (CCP) scores (median 57.3 vs. 44.0, p = 0.11) and genomic prostate scores (GPS; median 73.8 vs. 64.4, p = 0.15) were not significantly different. Similarly, expression of FOLH1, PCAT4, SCHLAP1, and SPINK1 on initial biopsy did not significantly differ among men who did and did not undergo grade progression. Conclusions: Use of MRI/US fusion biopsy facilitated resampling of the same clonal focus of cancer over time, with high concordance of ERG status determined by both IHC and NGS. Derived genomic classifiers and candidate individual gene expression markers measured on initial biopsy tissue were not significantly different between patients who progressed and those who did not.
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Demetrio, D., A. Magalhaes, M. Oliveira, R. Santos, and R. Chebel. "11 Invivo-derived embryo pregnancy rates at Maddox Dairy from 2008 to 2018." Reproduction, Fertility and Development 32, no. 2 (2020): 130. http://dx.doi.org/10.1071/rdv32n2ab11.
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Maddox Dairy, located in Riverdale, CA, USA, is a Holstein herd that milks 3500 cows with a 305-day mature-equivalent milk production of 12 800 kg, and they have been producing high genetic animals by embryo transfer (ET) since the early 1980s. Invivo-derived embryos from Holstein donors were transferred fresh (grade 1 or 2) or frozen (grade 1), at morula (4), early blastocyst (5), or blastocyst (6) stage, to virgin heifers (VH, natural oestrus, 13-15 months old) or lactating cows (LC, Presynch-Ovsynch, 86 days in milk, first or second lactation) 6 to 9 days after oestrus. Pregnancy diagnosis was done by transrectal ultrasonography at 32-46 days in VH and by the IDEXX PAG test at 30 days in LC. June, July, August, September, and October were called critical months (first service AI conception rate drops below 44%) and compared with the other months. The data from 32 503 ETs between January 2008 and December 2018 are summarised on Table 1. Pregnancy rates (PR) are lower for LC recipients than for VH. Embryo transfers performed 7 or 8 days after oestrus had higher PR in both types of recipients and embryos, but Day 6 and 9 oestrus are also used with fair results. The season does not seem to affect PR. There is not enough difference in the combination of stage and days from oestrus for invivo-derived embryos. These numbers do not belong to a planned experiment. Several management changes during the years were made, which make it very difficult to apply statistical methods to analyse the data correctly. They are used as a tool to make decisions in an attempt to improve future results. Table 1.Pregnancy rate (PR) of virgin heifers (top) and lactating cows (bottom)-fresh (SH) and frozen (OZ) invivo-derived embryo transfer1 Heat-months SH-ST4 SH-ST5 SH-ST6 SH-All OZ-ST4 OZ-ST5 OZ-ST6 OZ-All PR% n PR% n PR% n PR% n PR% n PR% n PR% n PR% n Heifers 6 d-CM 62 934 66 243 68 69 63 1246 56 473 58 219 62 42 57 734 6 d-OM 62 1623 67 489 69 211 64 2323 56 600 55 296 48 137 55 1033 6 d-T 62 2557 67 732 69 280 63 3569 56 1073 57 515 51 179 56 1767 7 d-CM 64 1506 68 495 67 221 65 2222 60 822 62 340 63 156 61 1318 7 d-OM 66 2723 68 1021 69 510 67 4254 57 1120 59 581 57 231 58 1932 7 d-T 66 4229 68 1516 69 731 67 6476 58 1942 60 921 60 387 59 3250 8 d-CM 65 1348 64 518 67 322 65 2188 59 595 64 258 63 108 61 961 8 d-OM 66 2166 68 886 70 510 67 3562 61 770 60 364 51 130 60 1264 8 d-T 66 3514 67 1404 69 832 66 5750 60 1365 62 622 56 238 60 2225 9 d-CM 60 109 56 43 70 20 60 172 60 5 33 6 50 4 47 15 9 d-OM 58 129 63 57 60 40 60 226 63 16 50 18 75 4 58 38 9 d-T 59 238 60 100 63 60 60 398 62 21 46 24 63 8 55 53 All-CM 64 3897 66 1299 67 632 65 5828 58 1895 61 823 63 310 60 3028 All-OM 65 6641 67 2453 69 1271 66 10 365 58 2506 58 1259 53 502 58 4267 All-T 65 10 538 67 3752 69 1903 66 16 193 58 4401 60 2082 57 812 59 7295 Lactating cows 6 d-CM 54 265 48 86 50 12 53 363 38 141 31 77 50 10 36 228 6 d-OM 49 463 52 203 45 56 50 723 46 101 48 54 59 27 48 182 6 d-T 51 728 51 289 46 68 51 1086 41 242 38 131 57 37 42 410 7 d-CM 54 755 59 274 56 103 55 1137 43 928 48 450 43 192 45 1570 7 d-OM 55 914 66 367 54 109 58 1393 46 1052 45 564 47 353 46 1969 7 d-T 55 1669 63 641 55 212 57 2530 45 1980 46 1014 46 545 45 3539 8 d-CM 63 252 68 82 76 33 65 368 48 219 56 80 42 33 50 332 8 d-OM 61 257 64 161 53 47 61 466 50 191 53 77 56 16 51 284 8 d-T 62 509 65 243 63 80 63 834 49 410 55 157 47 49 50 616 All-CM 56 1272 58 442 60 148 57 1868 44 1288 47 607 43 235 45 2130 All-OM 55 1634 62 731 51 212 56 2582 47 1344 46 695 48 396 47 2435 All-T 55 2906 60 1173 55 360 57 4450 45 2632 47 1302 46 631 46 4565 1ST=stage; CM=critical months (June, July, August, September, and October); OM=other months.
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Moser, Othmar, Norbert Tripolt, Peter Pferschy, Anna Obermayer, Harald Kojzar, Alexander Mueller, Hakan Yildirim, Caren Sourij, Max Eckstein, and Harald Sourij. "Performance of the Intermittently Scanned Continuous Glucose Monitoring (isCGM) System during a High Oral Glucose Challenge in Adults with Type 1 Diabetes—A Prospective Secondary Outcome Analysis." Biosensors 11, no. 1 (January 15, 2021): 22. http://dx.doi.org/10.3390/bios11010022.
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To assess intermittently scanned continuous glucose monitoring (isCGM) performance for different rates of change in plasma glucose (RCPG) during glycemic challenges in type 1 diabetes (T1D). Nineteen people with T1D (7 females; age 35 ± 11 years; HbA1c 7.3 ± 0.6% (56 ± 7 mmol/mol)) performing two glycemic challenges (OGTT) were included. During OGTTs, plasma glucose was compared against sensor glucose for timepoints 0 min (pre-OGTT), +15 min, +30 min, +60 min, +120 min, +180 min, and +240 min by means of median absolute (relative) difference (MARD and MAD) and Clarke Error Grid (CEG), then was stratified for RCPG and glycemic ranges. Overall, MARD was 8.3% (4.0–14.8) during hypoglycemia level 1 18.8% (15.8–22.0), euglycemia 9.5% (4.3–15.1), hyperglycemia level 1 9.4% (4.0–17.2), and hyperglycemia level 2 7.1% (3.3–11.9). The MARD was associated with the RCPG (p < 0.0001), detailing significant differences in comparison of low, moderate, high, and very high RCPG (p = 0.014). Overall, CEG resulted in 88% (212 values) of comparison points in zone A, 12% (29 values) in zone B, and 0.4% (1 value) in zone D. The isCGM system was accurate during OGTTs. Its performance was dependent on the RCPG and showed an overestimation of the actual reference glucose during hypoglycemia.
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Bayram, John M., David F. Hamilton, and David H. Saunders. "Epidemiology of American Football Injuries at Universities in the United Kingdom." Orthopaedic Journal of Sports Medicine 8, no. 10 (October 1, 2020): 232596712096020. http://dx.doi.org/10.1177/2325967120960206.
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Background: College-level American football injury data are routinely collected; however, data relating to American football injuries at universities in the United Kingdom have never been reported. Purpose: To describe the epidemiology of UK university American football injuries. Study Design: Descriptive epidemiology study. Methods: An online survey tool was used to collect the injury data of 410 players from 56 UK university teams who participated in the 2014-2015 British Universities and College Sports American football season. Survey data were collected from January to February 2016 and were analyzed to determine the incidence and patterns of injury. Results: Overall, 710 injuries and 204 concussions were self-reported among the 410 participants, of which 334 (81.5%) were injured and 131 (32.0%) experienced concussion symptoms. The rate of injury per 100 athlete-seasons was greater in defensive players (195.3) than offensive players (155.1). The most common injuries were knee and ankle ligament injuries. Most injuries were classified as severe (time loss of >4 weeks). Conclusion: UK university American football injuries differ markedly from those reported for US colleges. UK university players appear to have less playing experience, greater concussion risks, more severe injuries, and a greater proportion of injuries in defensive players versus offensive players.
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Kim, J. S., H. S. Kim, and K. A. Lee. "THU0332 ULTRASONOGRAPHIC EVALUATION FOR SALIVARY GLAND INVOLVEMENT IN SYSTEMIC SCLEROSIS." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 396.1–397. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3432.
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Background:While salivary gland ultrasound (SGUS) has widely used for evaluating Sjögren’s syndrome, information on SGUS findings of systemic sclerosis (SSc) is limited.Objectives:We aimed to evaluate the salivary gland involvement in patients with SSc using SGUS.Methods:We consecutively included patients with SSc fulfilling American College of Rheumatology/European League against Rheumatism (ACR/EULAR) 2013 classification criteria, primary Sjögren’s syndrome (pSS) fulfilling ACR/EULAR 2016 classification criteria, and idiopathic sicca syndrome. All patients underwent SGUS examination using the Outcome Measures in Rheumatology (OMERACT) definition of a SGUS scoring system. The hyperechoic bands using 0-3 scoring system (none/<25% of the parenchyma/25-50% />50%) and intraglandular power Doppler signal (PDS) were assessed. Hocevar scoring system (0-48) comprising parenchymal echogenicity, homogeneity, hypoechoic areas, hyperechogenic reflections, and clearness of posterior borders were also evaluated.Results:A total of 147 patients were included in the study: SSc (n=59), pSS (n=56), and idiopathic sicca syndrome (n=32). The proportion of the highest OMERACT grades among the four glands≥ 2 were significantly higher in SSc (54.2%) and pSS (62.5%) than idiopathic sicca syndrome (3.1%). Total OMERACT SGUS scores, total fibrosis scores, Hocevar score were significantly higher in SSc and pSS compared to idiopathic sicca syndrome (Table 1). The proportion of the highest fibrosis grades among the four glands ≥2 were significantly higher in SSc (79.7%) than pSS (62.5%) and idiopathic sicca syndrome (46.9%). There were no significant differences in PDS among 3 groups. Twenty-one patients (65.6%) of 32 SSc patients with OMERACT grade ≥2 were anti-centromere antibody (ACA)-positive compared with 9/27 (33.3%) SSc patients with scores of 0–1. The positivity of anti-Ro-60/SSA were also significantly higher in SSc patients with SGUS grade ≥2 (37.5%) than those with SGUS scores of 0–1 (3.7%). In SSc group, there was no significant difference in auto-antibody profile and organ involvement between patients with fibrosis scores ≥2 and those with scores 0-1.Table 1.Characteristics of the study population included in the studySSc(n =59)pSS(n =56)Idiopathic sicca syndrome(n =32)P- value(SSc vs pSS)P- value(SSc vs idiopathic sicca)P- value(pSS vs idiopathic sicca)Age, mean (SD), years54.8 (12.1)60.5 (11.9)62 (11.2)0.0130.0060.559Female, n (%)53 (89.8)56 (100)28 (87.5)0.0280.7370.015Anti-Ro-60/SSA, n (%)13 (22.0)39 (69.6)7 (21.9)<0.0010.986<0.001ACA, n (%)30 (30.8)8 (14.3)2 (6.3)<0.001<0.0010.238Anti-topoisomerase, n (%)16 (27.1)0 (0)0 (0)<0.001<0.0011.000Max OMERACT US grade ≥ 2, n (%)32 (54.2)35 (62.5)1 (3.1)0.369<0.001<0.001Total SGUS scores, median (IQR)4.0 (6)7.0 (8)0 (1)0.231<0.001<0.001Max fibrosis US grade ≥ 2, n (%)47 (79.7)35 (62.5)15 (46.9)0.0420.0040.263Total fibrosis scores, median (IQR)6 (3)6 (6)4 (4)0.674< 0.0010.006PDS sum scores of four salivary glands, median (IQR)2 (5)0 (4)0 (2)0.1310.1521.000Conclusion:Based on OMERACT definitions for SGUS, more than half of the patients with SSc, especially those with ACA, had salivary gland involvement. Salivary glandular fibrosis is more prominent in patients with SSc than those with pSS and idiopathic sicca syndrome.References:[1]Jousse-Joulin S, et al. Video clip assessment of a salivary gland ultrasound scoring system in Sjogren’s syndrome using consensual definitions: an OMERACT ultrasound working group reliability exercise. Ann Rheum Dis. 2019;78(7):967-73.Disclosure of Interests:None declared
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Puzhel, A. O., V. A. Borisov, A. R. Osipov, I. V. Petlin, A. D. Kiselev, and L. N. Adeeva. "Fluoride processing of oil hydrocarbon cracking catalyst with REE concentrate extraction." Izvestiya Vuzov Tsvetnaya Metallurgiya (Universities Proceedings Non-Ferrous Metallurgy) 1, no. 1 (February 11, 2021): 28–35. http://dx.doi.org/10.17073/0021-3438-2021-1-28-35.
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It is proposed to use a spent cracking catalyst of petroleum hydrocarbons containing 1 wt.% of rare earth element (REE) oxides as an alternative REE feed source. The study covers the process of removing silicon in the form of ammonium hexafluorosilicate (NH4)2SiF6 by sintering an oil cracking catalyst sample with NH4F and subsequent (NH4)2SiF6 sublimation to produce an aluminum-containing concentrate of rare earth elements. The orthogonal central compositional planning of the experiment was used to study the effect of three factors: sublimation temperature (350 to 400 °С), duration (40 to 80 min), and weight of the catalyst fluorinated sintered mass (5 to 10 g) on the (NH4)2SiF6 sublimation completeness. Results obtained in the experiment were used to build a second-order model, which correlate with experimental data. The dynamics of (NH4)2SiF6 sublimation removal was determined for sublimation durations of τ = 10, 20, 40 and 80 min at processing temperatures of 350, 375 and 400 °C. The (NH4)2SiF6 removal degree values calculated based on the second-order model for τ = 44, 48, 52, 56, 60, 64, 68, 72, and 76 min fit well the experimental curves. Spectra of fluorinated catalyst samples before and after sublimation were studied using X-ray phase analysis and IR spectroscopy. The data of IR spectroscopy and X-ray phase analysis are in good agreement and show that (NH4)2SiF6, (NH4)3AlF6 and unreacted NH4F are present in the catalyst with NH4F sintered mass, and only aluminum compounds are detected – NH4AlF4 and AlF3 after sublimation. These data indicate the completeness of the sublimation removal of silicon from the catalyst and NH4F sintered mass with NH4AlF4 and AlF3 aluminum compounds only observed after sublimation. REE concentration is 15 % due to silicon removal.
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Caycho-Rodriguez, Tomas, José Ventura-León, Karla Azabache-Alvarado, Miguel Barboza-Palomino, Ingrid Fergusson Cárdenas, and Claudio Rojas-Jara. "Evidencias psicométricas iniciales de la escala de autoeficacia para envejecer (EAEE) en adultos mayores peruanos." Psychologia 12, no. 2 (July 1, 2018): 47–60. http://dx.doi.org/10.21500/19002386.3421.
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El estudio examina las evidencias psicométricas de la Escala de Autoeficacia para Envejecer (EAEE) en una muestra de 400 adultos mayores (75.2% mujeres y 24.8% hombres) de la ciudad de Trujillo (Perú) con una edad promedio de 73.37 años (DE = 7.86). Los participantes completaron la EAEE junto con medidas de satisfacción con la vida y depresión. El análisis factorial exploratorio (AFE), reveló que la EAEE presentaba una estructura factorial unidimensional. El análisis factorial confirmatorio (AFC), mostró que el modelo unidimensional tenía un ajuste aceptable (S-Bχ2 = 54.02, df = 345 p = .001; S-Bχ2/df = 1.54; CFI = .97; RMSEA = .052 [IC90% .021, .078]; y SRMR = .049; AIC= 118.96) y una confiabilidad adecuada (ω = .88 [IC95% .84 – .91]; α = .88 [IC95%: .84 - .91]). Los puntajes de la EAEE se correlacionaron de manera positiva con la satisfacción con la vida (r = .56, p< .01 [IC95%: .46, .79]) y negativa con la depresión (r = -.48, p< .01 [IC95%: -.37, -.73]). Los resultados sugieren que la EAEE presenta evidencias de validez basada en la estructura interna, convergente y discriminante, así como una adecuada confiabilidad.
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Chan, Kam C., Picheng Lee, and Gim S. Seow. "Why did management and auditors fail to identify ineffective internal controls in their initial SOX 404 reviews?" Review of Accounting and Finance 7, no. 4 (October 31, 2008): 338–54. http://dx.doi.org/10.1108/14757700810920757.
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PurposeThe purpose of this paper is to investigate the rationale for the failure of management and auditors to identify material internal control weaknesses (ICWs) in their initial Sarbanes‐Oxley Act of 2002 (SOX) 404 reviews, resulting in subsequent restatement of their opinions.Design/methodology/approachThe paper focuses on the factors associated with the failure of management and auditor to identify material internal controls weaknesses in their initial SOX 404 reports. Logistic regression is run on a sample of 56 firms that reported material internal controls weaknesses in their amended internal control reports and a control group of 344 firms that reported material internal controls weaknesses (i.e. ineffective internal controls) in their initial internal control reports for 2004.FindingsThe results show that firm size, the use of a Big 4 auditor, the ratio of non‐audit to total fees, and the need for accounting restatements are positively associated with the probability to file an amended internal control report. The number of ICWs and the number of audit committee meetings are negatively associated with the probability to file an amended internal control report.Practical implicationsThe paper's findings suggest that regulators and corporate boards should consider providing more guidelines on audit committee practices in addition to the audit committee structure. For example, more guidance by the board is needed to ensure that the audit committee is active in overseeing the company's auditor–client relationship and its internal audit function.Originality/valueEmpirical findings on factors associated with the failure of management and auditor to identify material ICWs in their SOX 404 review can contribute to an understanding of factors affecting the efficiency of the SOX 404 review by attributing such failure to either inherent factors such as operational complexity and industry membership or to managerial choices in auditor‐client relationship and corporate governance issues. An understanding of these factors can help companies and the Public Company Accounting Oversight Board and the Securities and Exchange Commission in their efforts to improve the effectiveness and the efficiency of the current SOX 404 process.
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Rizzo, Huber, Lilian Gregory, Jeferson Silva Carvalho, Gabriel José Moura Fraga, Fernanda Ramos Santana Santos, Ivy Tasso Gomes, José Wilton Pinheiro Junior, Zenáide Maria de Morais, and Silvio Arruda Vasconcellos. "Inquérito sorológico e fatores de riscos associados a ovinos soropositivos a Leptospira spp. no estado de Sergipe, Brasil." Medicina Veterinária (UFRPE) 14, no. 3 (October 19, 2020): 185. http://dx.doi.org/10.26605/medvet-v14n3-2448.
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O objetivo desse estudo foi determinar a ocorrência e os fatores associados à soropositividade para Leptospira spp. em ovinos do estado de Sergipe, Brasil, a partir de 1.200 amostras coletadas de sessenta propriedades das suas três mesorregiões entre os anos de 2011 e 2012. Foi observada, pela reação de soroaglutinação microscópica, 37,7% (452/1.200; IC: 0.357-0.396) de ovinos soropositivos com 93,3% (56) de propriedades com pelo menos um animal positivo. Os sorogrupos reagentes predominantes foram: Sejroe (32,1%), Icterohaemorrhagiae (23,5%) e Grippotyphosa (22,4%), com presença também de reações para Australis (7,1%), Pomona (3,8%), Autumnalis (3,5%), Panama (3,3%), Ballum (1,8%), Andamana (1,3%), Hebdomadis (0,9%) e Seranga (0,4%). As titulações variaram de 100 a 3.200, sendo que 77,2% delas ≤ 400. Os fatores associados à presença de ovinos soropositivos a Leptospira spp. foram: criações de subsistência (p=0,000, OR=3,08, IC95%=1,99-4,78) e com finalidade de produção de matrizes e reprodutores (p=0,000, OR=2,19, IC95%=1,46-3,28). As infecções por Leptospira spp. estão ostensivamente presentes nos rebanhos ovinos do estado de Sergipe, sendo necessária a adoção de práticas de manejo adequadas, direcionadas ao controle de roedores e criação consorciada com bovinos que podem levar a contaminação dos alimentos e pastagens.
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Walker, Amanda, Surabhi Batra, Kristin Wong, and Philip Kasirye. "Sickle Cell Disease and Hydroxyurea Knowledge, Views and Perceptions Among 400 Sickle Cell Patients and Caregivers at Mulago Hospital Sickle Cell Clinic: A Global Health Study in Kampala, Uganda." Blood 142, Supplement 1 (November 28, 2023): 2512. http://dx.doi.org/10.1182/blood-2023-189438.
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Background: In 2017, hydroxyurea was approved for the treatment of all sickle cell patients with genotype HbSS in Uganda following overwhelming support from the NOHARM trial conducted in a malaria endemic region at Mulago National Referral Hospital's Sickle Cell Clinic. Between January 2019 and June 2022, immediately following nationwide approval and distribution of hydroxyurea, hydroxyurea was prescribed a total of 4017 (51.2%) times out of the 7851 HbSS patient visits to the clinic according to data available from the clinic. Aims:The purpose of this study is to investigate the knowledge, perceptions, and beliefs of patients with sickle cell disease and their caregivers attending this clinic in Kampala regarding their disease, complications, genetic impact, general anticipated course of treatment or natural history of disease, and hydroxyurea. Methods: A total of 400 (56%) out of 713 patients were surveyed over a 3-week period using standardized, pretested questionnaires administered orally by trained research personnel in both English (253, 63%) and Luganda (147, 36.8%), which are the most common local languages and dialects spoken by patients in Kampala. Three-hundred and twenty-one (80.3%) participants were caregivers and 79 (19.8%) were children with sickle cell disease between 12- and 17-years-old. Results: Most participants reported receiving counseling about sickle cell disease (333; 83.3%) largely by hematologists (286; 85.9%), however, several knowledge gaps were identified. Two-hundred and ninety-seven (74.3%) participants reported not knowing the type of sickle cell or genotype of the patient. Moreover, presentation of various options did not significantly improve recognition of the correct genotype, with only 121 (30.3%) participants correctly identifying HbSS. Three-hundred and twenty-eight (82%) participants correctly identified the heritable transmission of the disease from both parents; however, caregivers exhibited limited understanding of genetic risk with only 31 (9.7%) correctly identifying the one in four chances of having a subsequent child with sickle cell disease when both parents are carriers. Hydroxyurea counseling was reported by 326 (81.5%) of participants, and 307 (76.7%) participants reported that the patient received hydroxyurea, with most patients taking the medication for at least 1 year. Of the 93 (23.5%) participants who identified the patient had never received hydroxyurea, 32 (34.4%) were uncertain if the patient would be eligible and 56 (57%) believed the patient was eligible to take the medication. Participants identified hydroxyurea benefits as decreases in pain (332; 83%), hospitalization (162; 40.8%), need for blood transfusion (148; 37%), need for pain medication (87; 21.8%), infections (42; 61%), weight loss (22; 31.9%), length of hospital stay (18; 4.5%), and incidence of stroke (10; 2.5%). Slightly more than half of patients had no concerns about hydroxyurea (218; 54.5%). Most patients with concerns (182; 45.5%) identified hydroxyurea's high cost as their main concern (141; 77.5%). Other rumors and fears about hydroxyurea included: negative affects on internal organs such as the liver or kidneys (54; 29.7%), other negative side effects (27; 14.8%), inaccessibility in pharmacies and remote areas (18; 10%), harm due to stopping or missing doses (16; 8.8%), ineffectiveness (16; 8.8%), additional indications as a cancer medication (9; 4.9%), and younger children's difficulty swallowing pills (6; 3.3%). Conclusion:Given the significantly improved morbidity and mortality of sickle cell patients who are adherent to hydroxyurea, it is necessary to address the rumors, misconceptions, and gaps in understanding of the genetic impact of the disease as well as the risks and benefits of hydroxyurea therapy. At the population level, learning is impacted by education levels, literacy rates, health literacy rates, and other cultural and societal factors, thus teaching should be culturally competent and inclusive with verbal and visual methods. The high cost of the medication and lack of consistent supply seem to be the most prohibitive factors in patient acceptance and adherence to take hydroxyurea. With only 1% of Uganda's population covered by health insurance, it is imperative for system-wide changes to address the affordability and accessibility of hydroxyurea and/or to extend the coverage of health insurance to those in need.
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Brzezińska-Ślebodzińska, Ewa, and A. B. Ślebodziński. "Changes in thyroxine, 3,3',5-triiodothyronine and 3,3'5'-triiodothyronine content in the thyroid gland and in serum to thyroid tissue iodothyronine ratios during ontogenesis in the fetal pig." Acta Veterinaria Hungarica 52, no. 4 (October 1, 2004): 379–87. http://dx.doi.org/10.1556/avet.52.2004.4.1.
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The concentrations of thyroxine (T4), 3,3',5-triiodothyronine (T3) and 3,3',5'-triiodothyronine (reverse T3; rT3) in thyroid gland tissue and serum of the fetal pig (n = 68) from day 39 to 113 of gestation were measured. Tracer quantities of iodothyronines, displaying the onset of thyroid hormone activity, were found in the thyroid tissue on day 39, i.e. before the appearance of a measurable quantity of iodothyronines in the serum. The T4 and T3 thyroidal content showed the first rise between days 56 and 76. Then, T3 was increasing sharply from day 92 till birth, while T4 content was decreasing from about day 76 to a low value between day 92 and 105, and then showing an increase shortly before birth. The rT3 content was the highest on day 39 and then it was steadily decreasing to reach a nadir on about day 76. Measurable amounts of thyroid hormones (TH) in the serum were observed not earlier than on day 46 of gestation. Near birth, the tissues of the pig fetus are in a milieu characterised by the highest blood TH concentrations. The serum to thyroid concentration ratio for rT3 and T4 was generally below 1.0 until the last trimester of gestation, when it was over 5.0 for rT3 and over 4.0 for T4. By contrast, the T3 serum to thyroid ratio was below 0.5 throughout the gestation. The results show that the fetal pig thyroid displays a low rT3 and T4 content, but the marked T3 elevation observed near term supports the view that a high production and secretion of T3 near term may be a critical factor for normal postnatal adaptation to extrauterine cooling in the pig.
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Blanchet, Didier, and Jean-Noël Biraben. "Essai sur le mouvement de la population de Paris et de ses environs depuis le XVIe siècle." Population Vol. 53, no. 1 (January 1, 1998): 215–48. http://dx.doi.org/10.3917/popu.p1998.53n1-2.0248.
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Résumé Biraben (Jean-Noël), Blanchet (Didier).- Essai sur le mouvement de la population de Paris et de ses environs depuis le XVIe siècle Représentant peut-être 15 % de la population urbaine de la France, Paris, malgré la perte de ses registres d'état civil en 1871, ne pouvait être négligé dans l'enquête nationale de reconstitution du mouvement de la population. Sur les 5 millions d'actes détruits, qui allaient de 1515 à 1859, 2,9 millions ont été reconstitués par la commission officielle de l'état civil, environ 0,2 million par la seconde reconstitution des Archives de Paris, 56 000 antérieurs à 1650 avaient été recopiés par Laborde, et à peu près autant par Guiblet. Avec diverses autres copies, on peut estimer à 3,3 millions le nombre d'actes rétablis. La représentativité de ce matériel disparate, testé par comparaison avec les relevés statistiques de l'époque, est plus incertaine lorsqu'on remonte dans le temps ; nous avons tenté avec lui une reconstitution numérique du mouvement de la population de Paris. Selon les registres de 87 paroisses sur les 202 qui entourent Paris à moins de 20 km, les aléas annuels présentent une bonne covariation qui laisse penser que la courbe de Paris n'est pas sans fondements. Nous nous sommes appuyés aussi sur les recensements les plus crédibles de Paris, soit 294 000 habitants en 1565, 220 000 après le siège de 1590, 440 000 en 1636, 480 000 en 1684, peut-être 529 000 en 1767, et 609 000 en 1792. Malgré de nombreuses tentatives pour borner la croissance de Paris (1548, 1644, 1672, 1719...) la population de la ville n'est restée stationnaire qu'entre 1672 et 1719, lors de la création de quatre villes nouvelles satellites.
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Blanchet, Didier, and Jean-Noël Biraben. "Essay on the Population of Paris and its Vicinity Since the Sixteenth Century (Population, 1-2, 1998)." Population Vol. 54, HS1 (December 1, 1999): 155–88. http://dx.doi.org/10.3917/popu.p1999.11n1.0188.
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Résumé Biraben (Jean-Noël), Blanchet (Didier).- Essai sur le mouvement de la population de Paris et de ses environs depuis le XVIe siècle Représentant peut-être 15 % de la population urbaine de la France, Paris, malgré la perte de ses registres d'état civil en 1871, ne pouvait être négligé dans l'enquête nationale de reconstitution du mouvement de la population. Sur les 5 millions d'actes détruits, qui allaient de 1515 à 1859, 2,9 millions ont été reconstitués par la commission officielle de l'état civil, environ 0,2 million par la seconde reconstitution des Archives de Paris, 56 000 antérieurs à 1650 avaient été recopiés par Laborde, et à peu près autant par Guiblet. Avec diverses autres copies, on peut estimer à 3,3 millions le nombre d'actes rétablis. La représentativité de ce matériel disparate, testé par comparaison avec les relevés statistiques de l'époque, est plus incertaine lorsqu'on remonte dans le temps ; nous avons tenté avec lui une reconstitution numérique du mouvement de la population de Paris. Selon les registres de 87 paroisses sur les 202 qui entourent Paris à moins de 20 km, les aléas annuels présentent une bonne covariation qui laisse penser que la courbe de Paris n'est pas sans fondements. Nous nous sommes appuyés aussi sur les recensements les plus crédibles de Paris, soit 294 000 habitants en 1565, 220 000 après le siège de 1590, 440 000 en 1636, 480 000 en 1684, peut-être 529 000 en 1767, et 609 000 en 1792. Malgré de nombreuses tentatives pour borner la croissance de Paris (1548, 1644, 1672, 1719...) la population de la ville n'est restée stationnaire qu'entre 1672 et 1719, lors de la création de quatre villes nouvelles satellites.
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Quispe H., Silvio, Roberto Miranda C., Edwin Yucra S., and Hernán Quispe H. "Uso y manejo productivo de suelos en la cuenca Huanquisco del municipio de Ancoraimes." CIBUM SCIENTIA 1, no. 1 (April 28, 2022): 24–31. http://dx.doi.org/10.53287/knke8587jx20f.
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El objetivo de la investigación, evaluar el manejo de suelo en tres comunidades del municipio de Ancoraimes (cuenca Huanquisco): Chinchaya, Cohani y Chojñapata. En la comunidad de Chinchaya el uso de suelo es para área urbana con un 3,6%, agricultura intensiva 21,5%, agricultura extensiva 18,5%, pastoreo extensivo 36,1% y arbustos con 18,4%. El uso de tractor es de un 65,0% para el cultivo de papa. Su cultivo de mayor importancia es la cebolla con 57,0%. En animales cuentan con bovinos (98,0%) y ovinos (59,0%); en la comunidad de Cohani, el uso de suelo está clasificado en área urbana 3,6%, agricultura intensiva 14,7%, agricultura extensiva 5,9%, pastoreo extensivo 73,7% y cuerpos de agua 2,1%. El uso de tractor es de un 49,0% para el cultivo de papa. Su cultivo de mayor importancia es la papa con 82,0%. En animales cuentan con bovinos (56%), ovinos (87,0%), llamas (90,0%) y alpacas (10,0%) y en la comunidad de Chojñapata, el uso de suelo está clasificado en área urbana 0,1%, agricultura intensiva 9,1%, pastoreo intensivo 56,6%, pastoreo extensivo 34,3% y cuerpos de agua 2,1%. El uso de yunta es de un 44,0% para el cultivo de papa. El cultivo de mayor importancia es la papa con 50,0%. En animales cuentan con bovinos (25,0%), ovinos (94,0%), llamas (96,0%) y alpacas (50,0%).
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Giebel, Sebastian, Sylwia Oborska, Joanna Romejko-Jarosinska, Jarosław Dybko, Joanna Mańko, Joanna Sawczuk-Chabin, Agata Szymańska, et al. "Plerixafor for patients who fail cytokine-or chemotherapy-based stem cell mobilization: Results of a prospective study by the Polish Lymphoma Research Group (PLRG)." Acta Haematologica Polonica 49, no. 4 (December 31, 2018): 234–39. http://dx.doi.org/10.2478/ahp-2018-0027.
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AbstractAutologous hematopoietic stem cell transplantation (autoHSCT) requires collection of sufficient number of hematopoietic stem cells. The goal of this study was to evaluate efficacy of plerixafor used in patients with lymphoid malignancies failing conventional stem cell mobilization.This was a prospective, non-interventional study. All consecutive patients (n = 109) treated with plerixafor in 11 centers were reported. The drug was used either in case of previous mobilization failure (n = 67) or interventionally, in case of insufficient CD34+ cell output during current mobilization (n = 42). Successful mobilization was defined as resulting in collection of ≥ 2 × 106 CD34+ cells/kg for single autoHSCT or ≥ 4 × 106 CD34+ cells/kg for double procedure.The overall rate of successful mobilization was 55% (55% for single and 56% for double autoHSCT). The median total number of collected CD34+ cells/kg was 2.4 (range, 0-11.5) for patients intended for a single transplantation while 4.0 (0.6-16.9) for double procedure. The number of circulating CD34+ cells increased after the use of plerixafor regardless of baseline values. The median fold increase was 3.3 (0.3-155). Data from this observational study confirm high efficacy of plerixafor used in routine clinical practice as salvage for patients with lymphoid malignancies failing conventional stem cell mobilization.
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Such, Pedro, Murat Yildirim, Jessica Madera-McDonough, and Leslie Citrome. "Safety And Efficacy of Aripiprazole 2-Month Ready-to-Use 960 mg in Adult Patients With Schizophrenia." CNS Spectrums 28, no. 2 (April 2023): 242–43. http://dx.doi.org/10.1017/s109285292300175x.
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AbstractBackgroundAripiprazole 2-month ready-to-use 960 mg (Ari 2MRTU 960) is a new long-acting injectable (LAI) antipsychotic formulation for gluteal administration every 2 months. This 32-week trial evaluated the safety, pharmacokinetics, and efficacy of multiple-dose administration of Ari 2MRTU 960 in clinically stable adults with schizophrenia or bipolar I disorder (BP-I), versus that of aripiprazole once-monthly 400 mg (AOM 400; an LAI indicated for the maintenance treatment of schizophrenia in adult patients stabilized with oral aripiprazole [indication varies by country]). Safety and efficacy outcomes in the subpopulation of patients with schizophrenia are reported here.MethodsPatients with schizophrenia were randomized to receive Ari 2MRTU 960 every 56±2 days or AOM 400 every 28±2 days. Safety and tolerability assessments included adverse event (AE) reporting, Visual Analogue Scale [VAS] scores (scale range: 0–100) for patient-reported injection site pain, and extrapyramidal symptom (EPS) monitoring. Efficacy was evaluated at Week 32 using mean (standard deviation [SD]) Clinical Global Impression – Improvement (CGI-I) score, and mean (SD) change from baseline in Clinical Global Impression – Severity (CGI-S) score, Subjective Well-being under Neuroleptic Treatment – Short Form [SWN-S] Total score, and Positive and Negative Syndrome Scale (PANSS) Total score.ResultsStudy completion rate was 79.3% (73/92 patients) in the Ari 2MRTU 960 group and 67.7% (63/93 patients) in the AOM 400 group. Demographics and disease characteristics were well balanced between groups at baseline (mean [SD] PANSS Total score: Ari 2MRTU 960, 62.0 [13.5]; AOM 400, 61.8 [13.5]; mean (SD) CGI-S score: Ari 2MRTU 960, 3.3 [0.9]; AOM 400, 3.1 [0.9]). Treatment-emergent AE (TEAE) incidence was 66.3% with Ari 2MRTU 960 and 63.4% with AOM 400. The most frequent TEAEs were increased weight (Ari 2MRTU 960, 21.7%; AOM 400, 18.3%) and injection site pain (Ari 2MRTU 960, 15.2%; AOM 400, 9.7%). Mean (SD) VAS score for pain after last injection was 1.5 (4.58) with Ari 2MRTU 960 and 1.3 (2.79) with AOM 400. Minimal change was seen in EPS in either group. At Week 32, mean (SD) CGI-I score was similar between groups (Ari 2MRTU 960, 3.5 [1.0]; AOM 400, 3.6 [0.9]). Minimal change from baseline was seen at Week 32 in CGI-S score and SWN-S Total score. There was no clinically meaningful difference between the groups for PANSS Total score (difference of least squares mean change from baseline [95% confidence interval]: -0.9 [-3.5, 1.8]; p=0.5154).ConclusionsIn patients with schizophrenia, administration of Ari 2MRTU 960, as compared with AOM 400, was generally well tolerated, and clinical stability was maintained during the study.FundingOtsuka Pharmaceutical Development & Commercialization, Inc. (Princeton, NJ, USA) and H. Lundbeck A/S (Valby, Denmark).
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Wendler, Wilsey M., Ty Lawrence, Michael S. Davis, Phil J. Rincker, Nathan Pyatt, and Wally Koers. "76 Camera vision grading and objective tenderness outcomes of steers fed lubabegron fumarate for the final 56 d of the feeding period." Journal of Animal Science 102, Supplement_3 (September 1, 2024): 225–26. http://dx.doi.org/10.1093/jas/skae234.262.
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Abstract Limited research has compared no beta-agonist, ractopamine and lubabegron in feedlot cattle. We evaluated carcass quality and yield variables using a camera grading instrument and also examined objective tenderness outcomes. Treatments were negative control (no beta-ligand; CON), Optaflexx (ractopamine hydrochloride, 300 mg·steer-1·d-1 for 35 d; OPT), and Experior (lubabegron fumarate, 36 mg·steer-1·d-1 for 56 d + 4 d removal; 0EXP) fed for 198 d. Additional EXP treatments investigated total days on feed (DOF) of 184 d (-14EXP), 212 d (+14EXP) and 226 d (+28EXP). Carcasses (n = 2,517) were instrument graded 24 h post-mortem. Longissimus tenderness and lipid content were evaluated in a subset (n = 361) of carcasses via slice shear force and ether extract. Statistical analyses were conducted using mixed models; pen was the experimental unit, treatment was the fixed effect, block was a random effect, and means were separated with the Tukey-Kramer adjustment. Longissimus muscle area (LMA) was 4.0 to 6.2 cm2 larger (P < 0.01) for steers fed EXP compared with CON, which did not differ from OPT. Weight corrected LMA (LMA:HCW) was 1.3 cm2/100 kg larger (P < 0.01) for -14EXP compared with CON. Marbling score was 31 to 39 points lower (P < 0.01) for -14EXP compared with CON and OPT, whereas 0EXP, +14EXP and +28EXP were similar to CON and OPT. Total number of fat pieces within the longissimus did not differ (P = 0.11) across treatments, however number of fat pieces in the lateral one-half of the longissimus decreased (P ≤ 0.03) for -14EXP and +28EXP, whereas +14EXP tended (P = 0.09) to decrease compared with CON. Total meat area was 3.7 percentage points greater (P < 0.01) for -14EXP compared with CON; +14EXP and +28EXP tended (P = 0.07) to be greater than CON. Total fat area was 1.6 to 1.8 percentage points less (P ≤ 0.02) for 0EXP, +14EXP, and +28EXP when compared with CON. Compared with CON, dorsal-ventral longissimus distance increased (P < 0.01) by 3.3 to 5.4% for -14EXP, 0EXP, +14EXP and +28EXP. Medial-lateral longissimus distance increased 1.9 to 2.5 % (P < 0.01) for +14EXP and +28EXP compared with CON, whereas -14EXP tended (P = 0.08) to increase. Percentage intramuscular fat (IMF) was similar (P ≥ 0.44) for +14EXP, +28EXP, and OPT compared with CON, whereas 0EXP tended (P = 0.09) to be less. Marbling score and IMF were moderately correlated (r = 0.66). Slice shear force values were 20.1% greater (P < 0.02) for +14EXP compared with CON, whereas 0EXP tended (P = 0.09) to be greater and +28EXP, -14EXP and OPT were similar (P ≥ 0.28) to CON. These findings illustrate the effect of EXP on carcass traits and tenderness in feedlot cattle.
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Snowdon, R., and G. F. Birch. "The nature and distribution of copper, lead, and zinc in soils of a highly urbanised sub-catchment (Iron Cove) of Port Jackson, Sydney." Soil Research 42, no. 3 (2004): 329. http://dx.doi.org/10.1071/sr03017.
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Iron Cove catchment (~1500 ha) on the southern shores of Port Jackson (Sydney) has been highly urbanised (>90%) for a considerable time (1800s). A map of the area was divided into squares 200 by 200 m and a soil sample was taken randomly in each defined area from the dominant land use type in each square (n = 374). The objectives of the study were to determine the distribution and sources of heavy metals (Cu, Pb, Zn) in surface soils over the catchment and to assess soil quality in terms of guidelines and bioavailability of these metals.The concentrations of Cu, Pb, and Zn were determined for total soil and on a normalised basis. These metals are elevated across the whole catchment, with mean total concentrations for Cu, Pb, and Zn of 62, 410, and 343 mg/kg and 50 percentiles of 44, 203, and 224 mg/kg, respectively, whereas mean enrichment over background is 2, 5.5, and 4.6 times, respectively. Such a wide, regional metal enrichment is probably related to atmospheric deposition from industry inside and beyond the catchment. The highest concentrations of most metals were in soils from the north-east part of the catchment in an area where dwellings and buildings are oldest and where major roads and railway lines converge. Normalise data suggest sources of these metals are roads, railway lines, and older lead-painted houses. Independent studies in the catchment support roads as being an important source of metals in the area. Total soil chemistry indicates that 34, 33, and 56% of the samples were above the Australian and New Zealand Environment and Conservation Council (ANZECC) and National Health and Medical Research Council (NH&MRC) guidelines for Cu, Pb, and Zn, respectively, and selective extraction procedures (EDTA and HCl) indicate that 46–86% of these metals may be bioavailable.
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Pimentel, Lindsey E., Sriram Yennurajalingam, Gary B. Chisholm, Tonya Edwards, Maria Guerra-Sanchez, Maxine Grace Jaucian De La Cruz, Marieberta Vidal, Kimberson Tanco, and Eduardo Bruera. "Impact of a dedicated supportive care center telephone triaging program (SCCTP) for patients with advanced cancer." Journal of Clinical Oncology 31, no. 31_suppl (November 1, 2013): 54. http://dx.doi.org/10.1200/jco.2013.31.31_suppl.54.
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54 Background: Due to high symptom burden in advanced cancer patients, ongoing symptom management for outpatient palliative care patients is vital. More patients are receiving outpatient care; Yet, most palliative care patients receive less than 2 follow ups. Nurse telephone care can improve quality of life in these patients. Our aim was to determine frequency and care provided by Supportive Care Center Telephone Program (SCCTP) in advanced cancer patients. Methods: 400 consecutive patients who utilized palliative care service, 200 from outpatient Supportive Care Center (SCC) and 200 from inpatient Palliative Care (IPC), were followed for 6 months starting 3/2012 to examine call frequency and reason and outcomes including pain and other symptoms [Edmonton Symptom Assessment Scale (ESAS) and Memorial Delirium Assessment Scale (MDAS)] associated with utilization of SCCTP. We also examined the effect of SCCTP interventions on pain, ESAS and counseling needs. Results: 375 patients were evaluable. Median age 59 years, 53% female, 70% white. Most frequent cancer type were gastrointestinal (20%, p < 0.0001) for IPC and thoracic (23%, p <0.0001) for SCC. SCC patients had higher prevalence of CAGE positivity (28% SCC vs 11% IPC, p <0.0001), ESAS SDS(p=0.0134), depression(p=0.0009), anxiety(p=0.0097) and sleep(p=0.0015); MDAS scores were significantly higher in IPC (p<0.0001).115/400 patients (29%) utilized SCCTP. 96/115 outpatients (83%) used the SCCTP vs 19/115 IPC (17%). Common reasons for calls were pain (24%), pain medication refills (24%) and counseling (12%). Of 115 phone calls, 340 recommendations were made; 43% (145/340) were regarding care at home; 56% of these recommendations were regarding opioids. Patients who utilized SCCTP had worse pain(p=0.0059), fatigue(p=0.0448), depression(p=0.0410), FWB(p=0.0149) and better MDAS scores(p=0.0138) compared to non-utilizers. Conclusions: There was more frequent SCCTP use by outpatients than inpatients. Most common reason for utilization was pain control. Frequently, recommendations were made to continue symptom management at home. Patients who utilized SCCTP had worse pain, fatigue, depression, well-being scores and better delirium scores.
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Suntharalingam, Mohan, Kathryn Winter, David H. Ilson, Adam Dicker, Lisa A. Kachnic, Andre A. Konski, Bapsi Chakravarthy, et al. "The initial report of RTOG 0436: A phase III trial evaluating the addition of cetuximab to paclitaxel, cisplatin, and radiation for patients with esophageal cancer treated without surgery." Journal of Clinical Oncology 32, no. 3_suppl (January 20, 2014): LBA6. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.lba6.
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LBA6 Background: RTOG 0436 is a randomized Ph III trial designed to evaluate the benefit of cetuximab added to the concurrent chemoradiation for patients undergoing non-operative management of esophageal carcinoma. Methods: Pts with biopsy-proven squamous cell or adenocarcinoma of the esophagus (T1N1M0; T2-4 AnyN M0; Any T/N M1a) were randomized to weekly concurrent cisplatin (50 mg/m2), paclitaxel (25 mg/m2), and daily radiation 50.4 Gy/1.8 Gy fractions ± weekly cetuximab (400 mg/m2 day 1 then weekly 250 mg/m2). Patients were stratified by histology, tumor size (< 5 cm vs > 5cm), and the status of celiac lymph nodal involvement. Overall survival (OS) was the primary endpoint, with a planned accrual of 420 pts to detect an increase in 2-year OS from 41% to 53%; 80% power and 1-sided 0.025 alpha. An interim analysis of cCR was planned for the first 150 of each histology. Results: The study accrued 344 pts from 2008-2013 and 328 were eligible. Based on interim analyses, the study stopped accruing adeno pts in 5/2012 and SCC pts in 1/2013. Pts were well matched for pretreatment characteristics: 80% with T3/4 disease, 66% N1, and 19% with celiac nodal involvement. Incidence of grade 3/4/5 treatment (tx) related AEs was 45%, 22%, 4% in Arm 1 (cetuximab) and 49%, 17%, 1% in Arm 2 (no cetuximab). A cCR rate of 56% was observed in Arm 1 vs 59% in Arm 2 (p=0.72). No differences were seen in cCR between tx arms for either histology. The 12 and 24 mo OS rates for cCR pts were 79% and 58% vs 53% and 30% for those with residual disease (p<0.0001). Median follow-up for all pts is 15.4 mos. The 12 and 24 mo OS (95% CI) for Arm 1 is 64% (56%, 71%) and 44% (36%, 52%) vs 65% (57%, 72%) and 42% (34%, 50%) for Arm 2 (p=0.70). Adeno pts (n=203) had a 12 and 24 mo OS of 65% and 43% for Arm 1 vs 64% and 41% for Arm 2 (p=0.37). The 12 and 24 mo OS for the 125 SCC pts was 62% and 46% for Arm 1 vs 67% and 43% for Arm 2 (p=0.97). Conclusions: The addition of cetuximab to concurrent chemoradiation did not improve OS. There were no differences in cCR rates by tx arm. These Ph III results point to little benefit for current EGFR targeted agents in the tx of esophageal cancer. Supported by RTOG CA21661 and CCOP CA3742 NCI grants and Bristol Myers Squibb. Clinical trial information: NCT00655876.
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Tallman, Martin, Gordon Dewald, Hillard Lazarus, Sharavi Gandham, Gene Nelson, Brent Logan, Jacob Rowe, et al. "Impact of Cytogenetics on Outcome of Mismatched Unrelated Donor Hematopoietic Stem Cell Transplantation for Adults with AML." Blood 104, no. 11 (November 16, 2004): 830. http://dx.doi.org/10.1182/blood.v104.11.830.830.
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Abstract Matched unrelated donor hematopoietic stem cell transplantation (MUD HSCT) is a potentially curative treatment for patients with acute myeloid leukemia (AML). The graft-versus-leukemia (GVL) effect may be potent enough to overcome the otherwise poor prognosis associated with AML though its efficacy for high risk cytogenetic subgroups is uncertain. To test this hypothesis, we analyzed outcomes by cytogenetic risk group in 324 patients in first complete remission (CR1), and 440 in CR2 undergoing NMDP-facilitated MUD HSCT between 1988–2002. Using the SWOG/ECOG classification of cytogenetic risk groups (Slovak et al. Blood, 2000) cytogenetics were classified as favorable in 14% of patients, intermediate in 71% and unfavorable in 16%. 56% of the patients were male and 42% were > 35 years at HSCT. 76% of patients and donors were matched at HLA-A, -B and -DRB1, 17% were mismatched at one or more loci and 7% were potentially matched (serologically matched at HLA-A and -B and potentially allele matched at -DR). Disease Status N Kaplan-Meier Estimate for Survival at 5 years Kaplan-Meier Estimate for Disease-Free Survival at 5 years Cumulative Incidence for 100 Day Transplant-Related Mortality Cumulative Incidence for Relapse at 5 years * p-value indeterminate; ** p=0.01 CR1 324 32 ± 6% 32 ± 5% 32 ± 5% 18 ± 4% Intermediate 227 33 ± 7% 32 ± 7% 31 ± 6% 16 ± 5%* Unfavorable 85 31 ± 11% 31 ± 10% 29 ± 10% 23 ± 9%* CR2 440 36 ± 5% 35 ± 5% 25 ± 4% 16 ± 3% Favorable 93 46 ± 10% 44 ± 10% 25 ± 9% 10 ± 6%** Intermediate 313 33 ± 6% 32 ± 5% 27 ± 5% 16 ± 4%** Unfavorable 34 37 ± 17% 38 ± 16% 15 ± 12% 32 ± 15%** These data suggest that with the exception of the 5-year relapse rate, results of cytogenetics have little apparent influence on the outcome for patients undergoing MUD HSCT for AML in CR1. In CR2, results in patients with favorable cytogenetics appear to be better than those with intermediate or unfavorable cytogenetics, but are not statistically significantly different. Effective GVL and protection against relapse is observed, even in high risk cytogenetic subgroups. In this retrospective study, other prognostic factors may influence the outcome, but overall survival for patients with unfavorable cytogenetics appears at least as good as previously reported for matched sibling HSCT.
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Allen, G., S. M. Illingworth, S. J. O'Shea, S. Newman, A. Vance, S. J. B. Bauguitte, F. Marenco, et al. "Atmospheric composition and thermodynamic retrievals from the ARIES airborne TIR-FTS system – Part 2: Validation and results from aircraft campaigns." Atmospheric Measurement Techniques 7, no. 12 (December 12, 2014): 4401–16. http://dx.doi.org/10.5194/amt-7-4401-2014.
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Abstract. This study validates trace gas and thermodynamic retrievals from nadir infrared spectroscopic measurements recorded by the UK Met Office Airborne Research Interferometer Evaluation System (ARIES) – a thermal infrared, Fourier transform spectrometer (TIR-FTS) on the UK Facility for Airborne Atmospheric Measurements (FAAM) BAe-146 aircraft. Trace-gas-concentration and thermodynamic profiles have been retrieved and validated for this study throughout the troposphere and planetary boundary layer (PBL) over a range of environmental variability using data from aircraft campaigns over and around London, the US Gulf Coast, and the Arctic Circle during the Clear air for London (ClearfLo), Joint Airborne IASI (Infrared Atmospheric Sounding Interferometer) Validation Experiment (JAIVEx), and Measurements, process studies, and Modelling (MAMM) aircraft campaigns, respectively. Vertically resolved retrievals of temperature and water vapour (H2O), and partial-column retrievals of methane (CH4), carbon monoxide (CO), and ozone (O3) (over both land and sea) were compared to corresponding measurements from high-precision in situ analysers and dropsondes operated on the FAAM aircraft. Average degrees of freedom for signal (DOFS) over a 0–9 km column range were found to be 4.97, 3.11, 0.91, 1.10, and 1.62 for temperature, H2O, CH4, CO, and O3, respectively, when retrieved on 10 vertical levels. Partial-column mean biases (and bias standard error) between the surface and ~ 9 km, when averaged across all flight campaigns, were found to be −0.7(±0.3) K, −479(±56) ppm, −11(±2) ppb, −3.3(±1.0) ppb, and +3.5(±1.0) ppb, respectively, whilst the typical a posteriori (total) uncertainties for individually retrieved profiles were 0.4, 9.5, 5.0, 21.2, and 15.0 %, respectively. Averaging kernels (AKs) derived for progressively lower altitudes show improving sensitivity to lower atmospheric layers when flying at lower altitudes. Temperature and H2O display significant vertically resolved sensitivity throughout the column, whilst trace gases are usefully retrieved only as partial-column quantities, with maximal sensitivity for trace gases other than H2O within a layer 1 and 2 km below the aircraft. This study demonstrates the valuable atmospheric composition information content that can be obtained by ARIES nadir TIR remote sensing for atmospheric process studies.
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PAI, Chih-Hung, Kuo-Min KO, and Troy SANTOS. "A Study of the Effect of Service Recovery on Customer Loyalty Based On Marketing Word Of Mouth in Tourism Industry." Revista de Cercetare si Interventie Sociala 64 (March 6, 2019): 74–84. http://dx.doi.org/10.33788/rcis.64.6.
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