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1
Banaszak, Beata. "Assessment of serum concentrations of matrix metalloproteinases-2, -3 and -9, and tissue inhibitor of metalloproteinases-1 in children with primary hypertension." Pediatria i Medycyna Rodzinna 18, no. 4 (March 31, 2023): 345–50. http://dx.doi.org/10.15557/pimr.2022.0051.
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Introduction: Primary hypertension is regarded to be a growing health concern in children. The pathogenesis of primary hypertension is multifactorial. The role of altered levels of matrix metalloproteinases has been proposed. In hypertension, metalloproteinases are engaged not only in vascular remodelling but also in activation of vasoconstrictive agents. Aim of the study: We aimed at comparing the serum concentrations of matrix metalloproteinases-2, -3 and -9, and tissue inhibitor of metalloproteinases-1 in children with primary hypertension and normotensive peers. Materials and methods: We surveyed 23 children with primary hypertension, aged 14.75 years (median; interquartile range, IQR 3.66) and 23 normotensive subjects, aged 14.66 years (median; IQR 6.25). Serum concentrations of matrix metalloproteinases-2, -3 and -9, and tissue inhibitor of metalloproteinases-1 were measured using enzyme-linked immunosorbent method, and the scores were compared with Mann–Whitney U test, with the level of significance at p ≤ 0.05. Results: In children with primary hypertension, serum concentration of matrix metalloproteinase-2 [178.1 (IQR: 35.84) vs. 99.9 (IQR: 20.1) ng/mL], -3 [6.47 (IQR: 1.75) vs. 2.67 (IQR: 1.08) ng/mL], -9 [191.1 (IQR: 52.75) vs. 58.34 (IQR: 18.99) ng/mL] and tissue inhibitor of metalloproteinases-1 [863.9 (IQR: 192.9) vs. 335.41 (IQR: 109.99) ng/mL] were significantly higher than in the normotensive controls (p < 0.00001). Matrix metalloproteinase-9/tissue inhibitor of metalloproteinases-1 ratio [0.22 (IQR: 0.1) vs. 0.18 (IQR: 0.05)] was also significantly elevated in the hypertensive participants (p = 0.008). Conclusions: Elevated serum concentrations of matrix metalloproteinases-2, -3 and -9, and tissue inhibitor of metalloproteinases-1 in children with primary hypertension may indicate their role in the development of hypertension and/or on the presence of vascular remodelling at an early stage of the disease.
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Xiao, Chang Run, and Wen Zhao Zhang. "Optimization Research for Receivers Arrangement of LBL Acoustic Positioning System with PSO Algorithm." Applied Mechanics and Materials 333-335 (July 2013): 41–44. http://dx.doi.org/10.4028/www.scientific.net/amm.333-335.41.
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Three optimization models were proposed according to the problems emerged from self-propelled model test. And the object function to evaluated acoustic positionings precision of some given receivers arrays was created. The genetic algorithm code to solve this optimization problem was developed and validated by optimization model 1 afterwards. The optimum arrangements for model 1 and model 3 were acquired by calculating such code. The cross arrays was certificated to be the optimum ones. One new method to arrange acoustic receivers in self-propelled model test was drafted.
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Yang, Qian, Xiaoguang Shi, Weibang Li, Kaishan Song, Zhijun Li, Xiaohua Hao, Fei Xie, et al. "Fusion of Landsat 8 Operational Land Imager and Geostationary Ocean Color Imager for hourly monitoring surface morphology of lake ice with high resolution in Chagan Lake of Northeast China." Cryosphere 17, no. 2 (March 1, 2023): 959–75. http://dx.doi.org/10.5194/tc-17-959-2023.
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Abstract. The surface morphology of lake ice remarkably changes under the combined influence of thermal and mechanical forces. However, research on the surface morphology of lake ice and its interaction with climate is scarce. A large-scale linear structure has repeatedly appeared on satellite images of Chagan Lake in recent years. The Geostationary Ocean Color Imager (GOCI), with a 1 h revisit, and Landsat 8 Operational Land Imager (OLI), with a spatial resolution of 30 m, provide the possibility for the study of hourly changes in the large-scale linear structure. We merged the Landsat and GOCI images, using an Enhanced Spatial and Temporal Adaptive Reflectance Fusion Model (ESTARFM), and extracted the lengths and angles of the linear structure. We monitored the hourly changes in the surface morphology during the cold season from 2018 to 2019. The average length of the linear structure in the completely frozen period was 21 141.57 ± 68.36 m. The average azimuth angle was 335.48 ± 0.23∘, nearly perpendicular to the domain wind in winter. Through two field investigations during the two recent cold seasons, we verified the linear structure as being ice fractures and ridges. The evolution of surface morphology is closely associated with air temperature, wind, and shoreline geometry.
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Mallikarjuna, Koduru, Surya Veerendra Prabhakar Vattikuti, Ravi Manne, Gangarapu Manjula, Keelapattu Munirathnam, Srinivas Mallapur, Najat Marraiki, et al. "Sono-Chemical Synthesis of Silver Quantum Dots Immobilized on Exfoliated Graphitic Carbon Nitride Nanostructures Using Ginseng Extract for Photocatalytic Hydrogen Evolution, Dye Degradation, and Antimicrobial Studies." Nanomaterials 11, no. 11 (October 31, 2021): 2918. http://dx.doi.org/10.3390/nano11112918.
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Due to modernization and the scarcity of fossil fuel resources, energy demand is continuously increasing. In this regard, it is essential and necessary to create a renewable energy source that can meet future energy demands. Recently, the production of H2 by water splitting and removing pollutants from the water has been essential for issues of energy and environmental demands. Herein, g-C3N4 and Ag-g-C3N4 composite structures have been successfully fabricated by the ultrasonication method. The physio/photochemical properties of prepared g-C3N4 and Ag-g-C3N4 were examined with different analytical techniques such as FTIR, XRD, UV-DRS, SEM, TEM, PL, and XPS analyses. The silver quantum dots (QDS) anchored to g-C3N4 structures performed the profound photocatalytic activities of H2 production, dye degradation, and antimicrobial activity under visible-light irradiation. The Ag/g-C3N4 composite with an Ag loading of 0.02 mole has an optimum photoactivity at 335.40 μmol g−1 h−1, which is superior to other Ag loading g-C3N4 composites. The synthesized Ag/g-C3N4 nanoparticles showed potential microbial inhibition activity during the preliminary screening, and the inhibition zones were comparable to the commercial antibiotic chloramphenicol. The loading of Ag into g-C3N4 paves the suppression, recombination and transfer of photo-generated electron-hole pairs, leading to the enhancement of hydrogen production, the diminishment of pollutants in water under visible light irradiation, and antimicrobial activity against multidrug-resistant pathogens.
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Leão, Enoque De Sousa, Jacira Neves da Costa Torreão, Marcos Jácome de Araújo, Leilson Rocha Bezerra, Carlo Aldrovandi Torreão Marques, Raimundo Ribeiro Ferreira, Romilda Rodrigues do Nascimento, Bárbara Silveira Leandro, and Ricardo Loiola Edvan. "Analysis of the potentiality haying of native forage species in semiarid region." Semina: Ciências Agrárias 38, no. 5 (October 3, 2017): 3319. http://dx.doi.org/10.5433/1679-0359.2017v38n5p3319.
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The objective of this study was to evaluate the potential hay production from Spiny Amaranth (Amaranthus spinosus), Hairy Woodrose (Merremia aegyptia), Malva (Sida galheirensis), Mucuna (Mucuna pruriens) and Ervanço (Froelichia humboldtiana), native forage species of the semiarid region of Brazil by observing morphological components of the plant, such as the dehydration curve, crude protein loss (CPL) curve, chemical composition of plant and hay and hay degradability in situ. There were differences (P < 0.05) among species on leaf, stem and inflorescence quantification with Ervanço, Hairy Woodrose, and Mucuna having a greater number of leaves. There was a linearly increasing response for the dehydration curve of the five forage plants species. Mucuna forage had the greatest hay point at 800 g kg-1 dried matter (DM) after 11.8 hours and Woodrose had a lower dehydration efficiency, which required 25 hours of sun exposure. There was no difference in CPL. Mucuna had the lowest crude protein (CP), neutral detergent fiber (NDF) and acid detergent fiber (ADF) content, 8.4, 67.7 and 73.8 g kg DM-1 in hay in relation to the plant, respectively. Ervanço, Spiny Amaranth, Hairy Woodrose and Malva hay had more of soluble fraction “a” of DM of 31.0, 26.2, 22.1 and 9.7 g kg-1 DM than Mucuna, respectively. Spiny Amaranth and Malva hay had values of 335.4 and 193.2 g kg-1 DM of fraction “b” more than Ervanço hay, respectively. For fraction “a’’ of CP, Spiny Amaranth and Hairy Woodrose hay obtained 312.6 and 227.4 g kg-1 CP more than that observed for Malva, respectively. Mucuna had better hay potential among the forage studied in the semiarid region of Brazil.
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Blanco-Garavito, Rocio, Polina Astroz, Salomon Yves Cohen, and Eric H. Souied. "Influence of Fasting followed by Acute Water Ingestion on Subfoveal Choroidal Thickness in Eyes of Healthy Subjects." Ophthalmology @ Point of Care 1, no. 1 (January 2017): oapoc.0000013. http://dx.doi.org/10.5301/oapoc.0000013.
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Purpose To investigate the influence of at least 12 hours of fasting followed by acute water ingestion on macular choroidal thickness in eyes of healthy subjects. Methods Prospective case series study including healthy volunteers from April 1, 2015 to May 31, 2015. Macular choroidal thickness was measured on enhanced depth imaging optical coherence tomography (EDI-OCT) and on swept-source (SS)-OCT after 12 hours of fasting, and 60 minutes after acute water ingestion (750 mL in 5 minutes). Results A total of 52 eyes of 26 healthy volunteers were included in this study. The mean age for participants was 32 years old. After 12 hours of fasting, the mean (±SD) subfoveal choroidal thickness was 335.43 (±104.82) μm on EDI-OCT and 286.16 (±80.32) μm on SS-OCT. The mean (±SD) subfoveal choroidal thickness after acute water intake was 352.32 (±120.36) μm and 290.5 (±85.86) μm, respectively. There was no significant difference between the mean subfoveal thickness at baseline and 60 minutes after acute water ingestion for any of the choroidal imaging techniques (p = 0.1386 for EDI-OCT and p = 0.0659 for SS-OCT). Conclusions These results suggest that choroidal circulation can physiologically quickly adapt to systemic vascular changes in healthy eyes. Choroidal thickness did not depend upon the hydration status for the subjects participating in this study.
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Quach, Y. Nhu, and Ocktaeck Lim. "An Investigation of the Effect of Propylene Gas Flame on Emissions and Temperature Distribution of a Preheated Metal Plate." Sustainability 15, no. 16 (August 12, 2023): 12306. http://dx.doi.org/10.3390/su151612306.
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This study investigates the effect of the propylene gas flame on the emissions and temperature distribution of the metal plate during the preheating process. Experimental tests were carried out using a preheating system with a cylindrical chamber for emissions measurement and a metal plate placed near the torch head. Emissions were measured using a gas analyzer, while the temperature distribution of the metal plate was measured using an infrared thermal camera and thermocouples. The findings reveal that the emissions decrease as the equivalence ratio is increased as it approaches a ratio of 1. However, when the appropriate equivalence ratio is reached, NOx emissions will rise and then gradually fall. The peak temperature of propane fuel is higher than that of other fuels because of the concentrated flame. Propane fuel can achieve a peak temperature of 347.65 °C, surpassing both propylene fuel (275.45 °C) and acetylene fuel (335.45 °C). Using a propylene gas flame results in a reduction in emissions of carbon monoxide and nitrogen oxides compared to a propane flame. But, acetylene fuel produces the most NOx emissions, reaching 450.79 ppm for the experimental conditions. Additionally, the temperature distribution of the preheated metal plate was more uniform with the propylene gas flame, indicating improved heat transfer. However, the peak temperature of the metal plate was slightly lower when using the propylene gas flame.
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Nazarchuk, Evgeny V., Oleg I. Siidra, Diana O. Nekrasova, Vladimir V. Shilovskikh, Artem S. Borisov, and Evgeniya Y. Avdontseva. "Glikinite, Zn3O(SO4)2, a new anhydrous zinc oxysulfate mineral structurally based on OZn4 tetrahedra." Mineralogical Magazine 84, no. 4 (April 30, 2020): 563–67. http://dx.doi.org/10.1180/mgm.2020.33.
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AbstractA new mineral glikinite, ideally Zn3O(SO4)2, was found in high-temperature exhalative mineral assemblages in the Arsenatnaya fumarole, Second scoria cone of the Great Tolbachik Fissure Eruption (1975–1976), Tolbachik volcano, Kamchatka Peninsula, Russia. Glikinite is associated closely with langbeinite, lammerite-β, bradaczekite, euchlorine, anhydrite, chalcocyanite and tenorite. It is monoclinic, P21/m, a = 7.298(18), b = 6.588(11), c = 7.840(12) Å, β = 117.15(3)°, V = 335.4(11) Å3 and R1 = 0.046. The eight strongest lines of the powder X-ray diffraction pattern [d in Å (I) (hkl)] are: 6.969(56)(00$\bar{1}$), 3.942(52)(101), 3.483(100)(00$\bar{2}$), 3.294(49)(020), 2.936(43)(120), 2.534(63)(201), 2.501(63)(20$\bar{3}$) and 2.395(86)(02$\bar{2}$). The chemical composition determined by electron-microprobe analysis is (wt.%): ZnO 42.47, CuO 19.50, SO3 39.96, total 101.93. The empirical formula calculated on the basis of O = 9 apfu is Zn2.07Cu0.97S1.98O9 and the simplified formula is Zn3O(SO4)2. Glikinite is a Zn,Cu analogue of synthetic Zn3O(SO4)2. The crystal structure of glikinite is based on OZn4 tetrahedra sharing common corners, thus forming [Zn3O]4+ chains. Sulfate groups interconnect [Zn3O]4+ chains into a 3D framework.
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Doma, Kenji, and Glen Bede Deakin. "The effects of strength training and endurance training order on running economy and performance." Applied Physiology, Nutrition, and Metabolism 38, no. 6 (June 2013): 651–56. http://dx.doi.org/10.1139/apnm-2012-0362.
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This study examined the acute effect of strength and endurance training sequence on running economy (RE) at 70% and 90% ventilatory threshold (VT) and on running time to exhaustion (TTE) at 110% VT the following day. Fourteen trained and moderately trained male runners performed strength training prior to running sessions (SR) and running prior to strength training sessions (RS) with each mode of training session separated by 6 h. RE tests were conducted at baseline (Base-RE) and the day following each sequence to examine cost of running (CR), TTE, and lower extremity kinematics. Maximal isometric knee extensor torque was measured prior to and following each training session and the RE tests. Results showed that CR at 70% and 90% VT for SR-RE (0.76 ± 0.10 and 0.77 ± 0.07 mL·kg–0.75·m–1) was significantly greater than Base-RE (0.72 ± 0.10 and 0.70 ± 0.11 mL·kg–0.75·m–1) and RS-RE (0.73 ± 0.09 and 0.72 ± 0.09 mL·kg–0.75·m–1) (P < 0.05). TTE was significantly less for SR-RE (237.8 ± 67.4 s) and RS-RE (275.3 ± 68.0 s) compared with Base-RE (335.4 ± 92.1 s) (P < 0.01). The torque during the SR sequence was significantly reduced for every time point following the strength training session (P < 0.05). However, no significant differences were found in torque following the running session (P > 0.05), although it was significantly reduced following the strength training session (P < 0.05) during the RS sequence. These findings show that running performance is impaired to a greater degree the day following the SR sequence compared with the RS sequence.
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Malli, Foteini, Despoina Papakosta, Katerina Antoniou, Maria Dimadi, Vlassis Polychronopoulos, Katerina Malagari, Anastasia Oikonomou, Demosthenes E. Bouros, and Zoe Daniil. "Combined pulmonary fibrosis and emphysema characteristics in a Greek cohort." ERJ Open Research 5, no. 1 (February 2019): 00014–2018. http://dx.doi.org/10.1183/23120541.00014-2018.
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BackgroundCombined pulmonary fibrosis and emphysema (CPFE) has recently received great attention, with studies suggesting that it presents a distinct clinical entity while others have challenged this hypothesis. This nationwide study aimed to describe a large cohort of Greek CPFE patients and to examine potential prognostic factors for survival.MethodsThis retrospective study included 97 patients with CPFE. Demographic and clinical data, pulmonary function tests, echocardiography results and bronchoalveolar lavage analysis were recorded.ResultsMost patients were male (94.8%) and 92% were current or ex-smokers. Spirometry results were abnormal (forced vital capacity (FVC) 72.9±19.9% pred and forced expiratory volume in 1 s/FVC 82.9±9.7%) with reduced diffusing capacity of the lung for carbon monoxide (DLCO) (42.3±17.4% pred). Mean systolic pulmonary arterial pressure was 41.9±19.7 mmHg and pulmonary hypertension was present in 58.8% of patients. Mean 6-min walk distance was 335.4±159.4 m. Mean emphysema score was 14.23±8.69% and mean interstitial lung disease (ILD) extent was 39.58±19.82%. Mean survival was 84 months (95% CI 72–96 months). Patients with DLCO ≥39% pred had better survival than patients with DLCO <39% pred (p=0.031). Patients with ILD extent ≥30% had worse survival than patients with ILD extent <30% (p=0.037).ConclusionsOur results indicate that CPFE patients have preserved lung volumes associated with disproportionately reduced DLCO, while reduced DLCO and increased ILD extent was associated with worse prognosis.
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Shan, Jun, Xintong Ding, Mengchang He, Wei Ouyang, Chunye Lin, and Xitao Liu. "Mechanism of birnessite-promoted oxidative dissolution of antimony trioxide." Environmental Chemistry 17, no. 4 (2020): 345. http://dx.doi.org/10.1071/en19193.
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Environmental contextThe release of antimony and its compounds to the environment can present a toxic hazard for humans. We evaluated the use of birnessite to dissolve antimony trioxide and found that birnessite accelerated the dissolution process, and ~50% of the oxidised antimony was absorbed. The results can help evaluate the bioavailability of antimony in the environment. AbstractThe most important naturally occurring forms of antimony (Sb) are the ore mineral stibnite (Sb2S3) and its principal weathering product antimony trioxide (Sb2O3). Moreover, most Sb is released into the environment as Sb2O3 from manufacturing, formulations, processing, and the use and disposal of Sb products. In this study, birnessite (δ-MnO2) was employed to promote Sb2O3 dissolution. The Sb2O3 dissolution rate accelerated from ~2% to >99% after 9 days of reaction, and more than 98% of the dissolved SbIII was oxidised into SbV in the presence of birnessite. The birnessite-promoted oxidative dissolution mechanism of Sb2O3 was studied through experiments on the effects of the reaction time and pH. The release rate of Sb in the aqueous phase at the initial stage (335.4 μmol L−1 day−1, pH 6.5) was much higher than that at the late stage (13.28 μmol L−1 day−1, pH 6.5), and when the pH increased from 4.7 to 8.0, the Sb release rate decreased from 351.2 μmol L−1 day−1 to 257.7 μmol L−1 day−1. The dissolution promotion effects of birnessite on Sb2O3 were the most evident under acidic and neutral conditions (the percentages of dissolved Sb2O3 under acidic and neutral conditions were 98.3% and 100.0% after 9 days of reaction). Not all of the produced SbV was released in the reaction solution because ~50% of it was adsorbed by birnessite, and the amount of Sb adsorbed increased with increasing pH. Therefore, alkaline conditions are shown to reduce the release of SbV by inhibiting Sb2O3 dissolution (86.7%) and enhancing SbV adsorption. These results could help clarify the geochemical cycle and fate of Sb in the environment.
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Zharikov, A. N., V. G. Lubyanskiy, A. R. Aliev, V. V. Seroshtanov, and K. E. Vlasov. "Experience in surgical treatment of enteroatmospheric fistulas in the late period of postoperative peritonitis." Acta Biomedica Scientifica 8, no. 2 (May 4, 2023): 225–36. http://dx.doi.org/10.29413/abs.2023-8.2.22.
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Background. Enteroatmospheric fistulas (EAF) that occur during the use of the “open abdomen” surgical tactics are a complex surgical pathology with a high mortality rate.The aim. To assess the effectiveness of treatment of various forms of enteroatmospheric fistulas in patients with postoperative peritonitis using vacuum aspiration technology.Methods. We assessed the results of the surgical treatment of 46 patients with EAF in the late course of postoperative peritonitis (PP). Three clinical and morphological groups were distinguished: group 1 (n = 24) – EAF in small wounds of the anterior abdominal wall; group 2 (n = 15) – EAF opening into limited cavities; group 3 (n = 7) – EAF opening into laparostoma wounds. In group 1, a fistula was formed using continuous aspiration devices or VAC systems. In group 2, we used continuous aspiration of intestinal contents from the cavity. In group 3, laparostoma was treated using vacuum devices with isolation of the intestinal fistula and simulation of a floating enterostoma.Results. Group 3 of patients with EAF was characterized by a high flow rate (1224.2 ± 210.3 ml), duration of treatment (87.3 ± 12.5 day), extensive laparostoma (335.4 ± 14.3 сm2), high mortality rate (57.1 %). The best results of treatment were obtained in groups 1 and 2. The flow rate was 675.8 ± 154.3 and 541.3 ± 114.1 ml, the duration of treatment was 2 or 3 times less (37.7 ± 6.1 and 26.4 ± 5.2 days), the mortality rate was 8.3 % and 6.7 % respectively.Conclusion. EAF that occur when using the “open abdomen” surgical tactics due to the impossibility of their isolation in extensive wounds of the anterior abdominal wall are complicated clinical and morphological forms. For their treatment, it is advisable to use VAC systems, aimed at the treatment of both the anterior abdominal wall wound itself and the intestinal fistula opening into it for its gradual extraterritorialization by modeling a floating enterostoma in a vacuum device.
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Abdullah, M. A. N., D. Pahlasari, A. Nurhaliza, U. Hasanah, E. M. Sari, C. I. Novita, and M. Ammar. "Identification of reproduction performance of Thoroughbred and Gayo horses in Bener Meriah Regency, Aceh Province, Indonesia." IOP Conference Series: Earth and Environmental Science 1341, no. 1 (May 1, 2024): 012014. http://dx.doi.org/10.1088/1755-1315/1341/1/012014.
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Abstract The objective of this research was to identify the reproductive performance of Gayo horses and Thoroughbred horses. This research was conducted in Bener Meriah District, Aceh Province through a survey method. In this case, the research location was chosen intentionally (purposive sampling). The total population of Gayo horses in Bener Meriah is currently 227 horses. Among them, 78 horses were taken as the research samples with minimum requirement that the horses involved have at least given birth 2 times. Furthermore, the required data in this study were the reproductive performance characteristics of Gayo horses and Thoroughbred horses including: (1) estrous cycle; (2) estrous duration; (3) first mating age; (4) gestation period; (5) foaling interval; and (6) postpartum mating age. Based on the results, the data obtained are that the average length of estrous cycle of Gayo horses is 20.75±1.67 days, while Thoroughbred horses is 29±1.59 days. Furthermore, the length of time in estrous for Gayo horses is 5.80±1.20 days, while Thoroughbred Horses is 7.30±1.70 days. In addition, the average first mating for Gayo horse is 3.78±1.19 years, while for Thoroughbred horses is 3.10 ± 0.65 years. Furthermore, the gestational period of Gayo horse has an average of 335.40±5.00 days, while for Thoroughbred horses is 336.66±3.41 days. The foaling interval of Gayo horse is 458.43±37.14 days, while Thoroughbred horse is 477±16.65 days. Last, the average postpartum mating of Gayo horse is 123.03± 37.73 days, while the Thoroughbred horse is 141.26±15.88. Furthermore, the data obtained identified that the reproductive performance of Gayo and thoroughbred horse in Bener Meriah Regency is in normal condition.
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Kumar, Suneel, Satish Kumar, A. K. Dhaka, Ved Prakash, Shesh nath Pandey, and Hanuman Prasad Pandey. "Effect of foliar supplementation of water soluble fertilizer on growth, yield and economics of wheat crop (Triticum aestivum L.)." Environment and Ecology 42, no. 1 (January 2024): 116–23. http://dx.doi.org/10.60151/envec/trxl5819.
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A field experiment was conducted during rabi season of 2015-16 at Agronomy Research Farm of Chaudhary Charan Singh Haryana Agricultural University, Hisar, Haryana, to evaluate the effects of foliar application of water soluble fertilizers on growth, yield attributes and yield of wheat. The soil of the experimental plot was sandy loam in texture, low in available nitrogen (131.3 kg ha-1), medium in available phosphorus (17.2 kg ha-1), and high in available potassium (335.4 kg ha-1). The soil was alkaline in reaction (pH 7.8). The experiment was laid out in randomized block design with 17 treatments having three replications. The treatments comprising two fertilizers level i.e., Recommended dose of fertilizer (RDF) (150 kg N + 60 kg P2O5 + 60 kg K2O ha-1) and 75% of RDF and supplemented with foliar application of water soluble fertilizers viz. Urea phosphate (17:44) @ 1.5%, NPK (18:18:18) @ 1.5%, ZnSO4 @ 0.5% and Urea 2% at different stages. One treatment was control where no fertilizer applied. Growth parameters viz, plant height, dry matter accumulation, crop growth rate and leaf area index were increased with T9 i.e., RDF along with foliar application of water soluble fertilizers NPK (18:18:18) @ 1.5% at 40 DAS followed by Urea phosphate (17:44) @ 1.5% at 65 DAS. Among treatments, application of RDF along with foliar application of water soluble fertilizers NPK (18:18:18) @ 1.5% at 40 DAS followed by Urea phosphate (17:44) @ 1.5% at 65 DAS exhibited the highest values of yield attributes, viz. effective tillers/ meter row length (mrl), number of spikeletes/spike, number of grains/spike and 1000-grains weight which led to the highest grain yield (6220 kg ha-1) However, alternate application of NPK (18:18:18) @ 1.5% and Urea phosphate (17:44) @ 1.5% or vice versa produced statistically similar grain yield of wheat at the same level of fertilizer application. RDF or 75% RDF along with foliar application of NPK (18:18:18) @ 1.5% was slightly superior as compared to RDF or 75% RDF along with foliar application of Urea phosphate (17:44) @ 1.5% irrespective of time of application.
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Abdrashitova, M. R., A. R. Abushaeva, and M. K. Sadigova. "Influence of structure-forming recipe ingredients on the quality of pumpkin marmalade." Innovations and Food Safety, no. 1 (May 7, 2024): 29–45. http://dx.doi.org/10.31677/2311-0651-2024-43-1-29-45.
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Analyzing the assortment of the market for marmalade products, it is worth noting that there is a tendency to introduce natural products in the form of vegetable or fruit puree into the recipe composition, as the demand for confectionery products for therapeutic, prophylactic, and functional purposes, as well as for products with dietary properties, is growing. This work aims to study the influence of structure-forming recipe ingredients on the quality of pumpkin jelly marmalade. Pumpkin puree was used as the primary raw material for producing jelly marmalade, food agar was used as a gelling agent, and natural honey was used as a sweetener. During the study, organoleptic, physicochemical, and microbiological quality indicators of semi-finished pumpkin products and finished marmalade samples were determined. The color assessment of the finished products was carried out using a colorimeter NR-UO (China). Pumpkin semi-finished and finished products meet regulatory documentation requirements regarding organoleptic, physico-chemical, and microbiological quality indicators. When food agar is used as a gelling agent, the degree of color increases due to the transparency of the structure, and the red (+a*) and yellow (+b*) components in samples containing food agar are successfully combined and give the finished product an attractive orange color. To increase the nutritional -value, it is proposed to use cinnamon or coconut flakes, which have beneficial properties, to sprinkle the surface of finished products. The price for 1 kg of pumpkin jelly marmalade was: control sample - 335.46 rubles, “Məkhəbbət” with cinnamon - 748.85 rubles, “Məkhəbbət” with coconut flakes - 725.36 rubles. For a new type of confectionery products, regulatory and technical documentation STO, TI, RC 00493497-005-2022 “Halal” pumpkin jelly marmalade “Məkhəbbət” has been drawn up.
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Jabboury, K. W., A. Wong, K. Sexton, L. Rogers, K. King, C. Reilly, S. Thomas, P. Curtis, O. Mangini, and R. Behar. "Limited impact of tamoxifen following dose-intensive L-FAC multimodality therapy of breast cancer." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 10741. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.10741.
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10741 Background: Front-line dose-intensive L-FAC has demonstrated a favorable 5-year relapse free survival pattern (ASCO 2004 #739). Tamoxifen was given for 5 years to ER+ patients after L-FAC completion. We evaluated the impact of adding tamoxifen to L-FAC. By design, this pilot study excluded low-risk patients not candidates for chemotherapy. Methods: 109 breast cancer patients were enrolled (4 excluded due to treatment violations) from 6/1989 to 1/2003: 20 Stage I (S), 52 S-II, 22 S-III, for a total of 94 patients. 11 S-IV patients were excluded from survival analysis. Adverse tumor presentations included: ER- 49, PgR- 60, P53+ 24, non-diploid 39, histological grade III 37, CerbB2+ 33. L-FAC included 72 hour (h) iv infusion 400mg/m2/day (d) 5-fluorouracil (F) modulated by iv bolus 200mg/m2/d X3 leucovorin (L), concomitantly with 24h iv d1 600–1000mg/m2 cyclophosphamide (C), 48h iv d2 + d3 60mg/m2 doxorubicin (A). S-I and S-II were given 6 courses and 8 for S-III. Increasing A + C dose level and/or shortening treatment intervals < 3 weeks with growth factors provided intensification. 40 patients received tamoxifen. Results: At a median follow-up of 74 months (range 9–214), 73 (78%) are alive (1 with relapse). Relapse free survival was: S-I 95%, S-II 81%, S-III 78%. At average course intervals of 18 days, dose intensity A/C mg/m2/wk was 24.2 / 335.4 with evidence of WHO grade III/IV stomatitis in 43%, neutropenia 59%, cumulative thrombocytopenia 50%, hand-foot syndrome 32% of patients. Aside from delayed relapse associated with tamoxifen, relapse-free survival >82 months was similar with and without tamoxifen. No relapse was observed after >53 months in ER- tumors despite showing higher frequency of adverse tumor risk factors. Conclusion: The impact of adding tamoxifen appears quite limited in a patient population with adverse tumor presentation treated with dose-intensive L-FAC. No significant financial relationships to disclose.
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Hayes, Craig P., Erica D’Aquila, Daniel Bertolino, and Bisrat K. Abraham. "1323. Clinic-Level Factors Associated with Antiretroviral Prescription Rates." Open Forum Infectious Diseases 6, Supplement_2 (October 2019): S478. http://dx.doi.org/10.1093/ofid/ofz360.1186.
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Abstract Background Despite overall high antiretroviral (ARV) prescription (Rx) rates for the treatment of HIV in New York City (NYC), clinic-level Rx rates can vary greatly by clinic. Previous literature suggests reasons for deferring ARV Rx include patient readiness or comorbidities and provider biases. We investigated the impact of these and other factors on clinic-level ARV Rx rates within NYC. Methods Data were obtained from the 2016 HIV Clinic Survey which contained questions related to clinic capacity and other clinic and patient characteristics. Multivariate linear regression models were developed from literature sourced variables and manual stepwise selection. These models were evaluated for predictive strength based on their respective root mean square error (RMSE) and adjusted R-squared (AR2) values. Results Among the 104 HIV primary care clinics, representing the care of 49,654 people living with HIV (PLWH), ARV Rx rates ranged from 41.4% to 100.0% (IQR: 92.1%-99.6%). An increase in clinic-level ARV Rx rates was found to be significantly associated with an increase in clinic-level viral load suppression rates. In the stepwise multiple linear regression model (Table 1), decreases in ARV Rx rates were associated with several factors: (1) care delivered at three specific healthcare networks; (2) infrequently seeing patients with excessive alcohol use; (3) a high proportion of PLWH ages 24 and below; (4) a low proportion of the clinic population that were PLWH; (5) a low proportion of Hispanic/Latino patients; (6) and a high number of other medical services available on-site (P < 0.05). This model was found to have a 20.4% reduction in the RMSE and a 335.4% increase in the AR2 value when compared with the literature sourced model (Table 1), indicating greater predictive accuracy and greater explanation of the variability in clinic-level ARV rates. Conclusion ARV Rx rates were better predicted by the model adjusting for clinic-level factors previously unreported in the literature including network affiliations, the number of medical services provided, and the proportion of PLWH seen at the clinic. Given the role of ARVs in clinical outcomes, it is important to further explore and address how these clinic-level factors may support or obstruct the prescribing of ARVs in order to support the care of PLWH. Disclosures All authors: No reported disclosures.
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Garzanova, L., L. P. Ananyeva, O. Koneva, O. Ovsyannikova, O. Desinova, M. Starovoytova, R. Shayakhmetova, and A. Khelkovskaia-Sergeeva. "AB0707 Changes of immunoglobulin G and frequency of infections in systemic sclerosis patients during long-term rituximab therapy." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 1480.1–1480. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3671.
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BackgroundDecrease of immunoglobulin G (IgG) could often be observed during rutuximab (RTX) therapy in systemic sclerosis (SSc) and other autoimmune diseases. Lower lever of IgG could be associated with an increased risk of secondary infectious complications. However, there are very few data on changes of IgG in SSc during long-term RTX therapy.ObjectivesTo evaluate changes of Ig G and the frequency of infectious adverse events (AE) in SSc patients (pts) on RTX therapy during long-term follow-up.MethodsOur prospective study included 78 pts with SSc received RTX therapy. The mean follow-up period was 50.2±23 months. The mean age was 48.2±13.7 years, female-64 pts (82%), the diffuse cutaneous subset of the disease had 48 pts (62%), limited - 24 (31%), overlap - 6 (7%). The mean disease duration was 5.4±3.4 years. 92% of pts were positive for ANA and 71% of them were positive for antitopoisomerase-1. All pts received prednisolone at a dose of 11.8±4.1 mg/day, immunosupressants at inclusion received 40% of them. The IgG was evaluated over the periods: at baseline (point 0), 12-18 mo (point 1), 24-60 mo (point 2) and 66-84 mo (point 3) after initiation of RTX therapy. IgG levels was measured using ELISA. Normal IgG reference values ranged within 7.0-16.0 g/l. AE were assessed and recorded by a physician at a hospital immediately after the infusion of RTX, then by patient reported outcome during the observation period. Severe AE were defined as those that required hospitalization for more than 24 hours and life-threatening situations. The results are presented in the form of mean values and standard deviations.ResultsThere was a significant decrease of IgG during RTX therapy (Table 1). However, the level of IgG remained within normal limits. Initially lower level of IgG had 6 pts (8%). And further at point 1 there was 12 pts (15%) with decrease of IgG below normal limits, at point 2 - 12 pts (15%) and at point 3 - 5 pts (6%). When we compared the level of IgG between point 2 and 3 - no significant differences were found.Table 1.Changes of IgG level during RTX treatment.ParametersPoint 0 (n=78)Point 1(n=78)Point 2(n=76)Point 3(n=27)PPoint 0-1PPoint 0-2PPoint 0-3IgG, g/l, M±σ12.3±4.210.6±3.49.6±2.89.6±2.60.00010.00010.01Cumulative mean dose of RTX, g, M±σ-1.8±0.53.9±1.34.8±2.1---AE was evaluated over the period of 335.4 patient-years (PY). Infectious AE were reported in 34 patients (44%), the overall frequency was 10.2/100 PY (95% Confidence Interval (CI) 7.1-13.8). No serious opportunistic infections were reported. The highest frequency of infectious AE was observed in the first 2-6 months after the first infusion of RTX, however these were mainly mild AE (82%). The frequency of serious infections was 1.8/100 PY (95% CI 0.7-3.8). There was a decrease of infectious AE in the follow-up period (4.4/100 PY, 95% CI 2.5-7.2 – at period from 24 month of RTX therapy).ConclusionIn our study, a significant decrease of IgG was noted in SSc pts during the first 5 years of RTX therapy, but later its level stabilized and remained within normal limits. A decrease of IgG in the first year after the initiation of RTX therapy was accompanied by an increase in the frequency of infectious AE. However, with an increase of the cumulative dose of RTX, there was no increase in infectious AE. Monitoring of IgG levels may be useful for SSc pts on RTX therapy for early identification of the risk for developing infectious complications.Disclosure of InterestsNone declared
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Smith, Louise, Kate L. E. Phillips, and Russell D. Keenan. "Hydroxyurea Therapy for Sickle Cell Disorders in Childhood: Adherence to Therapy Transforms Lives and Needs to be the Focus - the Experience of Alder Hey Children's Hospital." Blood 126, no. 23 (December 3, 2015): 990. http://dx.doi.org/10.1182/blood.v126.23.990.990.
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Abstract Following Baby HUG trial results and other recent publications it is recommended by US evidence based guidance (NHLBI, 2014) that all children with sickle cell disorders be offered Hydroxyurea/Hydroxycarbamide (HU) therapy from 9 months. In the UK this is generally not the practice and there remains great reluctance to use HU. Only a minority of patients in the UK are offered HU therapy and many have never heard of it. There is no information at all on HU on the national UK Sickle Cell Society website. Here, we present the experience of our first 37 patients on HU therapy over a total of 975 patient months, specifically the effects of good adherence to HU therapy. Our target was to aim for daily doses of 35mg/kg. 10 patients were identified as poor adherers based on parent admission and failure to collect prescriptions regularly enough to maintain daily dosing, all other patients were considered to have good adherence. Doses actually achieved in patients who had been on therapy for more than 6 months had a mean of 28.5mg/kg. Overall, haemoglobin (Hb) level increased post-HU treatment to 92.0g/L from 80.6g/L, while reticulocytes decreased from 335.4 x109/L to 127.6 x109/L (n=37; p <0.0001 in both cases). 2 patients had minor transient cytopenia which recovered quickly without the need for dose reduction. In those patients with doses <26mg/kg, HbF was 20.4% as compared to 29.2% in those on doses >26mg/kg (p =0.0151). This suggests we have not reached the maximum tolerated dose in some patients and could continue to push doses higher with the benefit of improving HbF levels further. In 27 patients, who say that they are adhering to daily HU therapy and are collecting prescriptions regularly, HbF was 30.6%, significantly higher than the 14.9% recorded in the poor adherer group (p <0.0001; Figure 1A). In good adherers who had been on therapy for more than 6 months, 5/24 achieved HbF of >40% and had HbS levels approaching trait. No patient failed to respond as measured by rise in HbF or reduction in crisis symptoms and only 4/24 failed to achieved HbF of >20%, but still had excellent increases from pre-HU therapy. 3 of these 4 have not reached their maximum dose yet and we will be increasing the HU further. In good adherers, Hb increased to 95.8 g/L compared to 84.8g/L in poor adherers (p =0.0380; Figure 1B) and reticulocytes reduced to 102 x109/L in good adherers compared to 176 x109/L in poor adherers (p =0.0034; Figure 1C). 19/24 good adherers achieved normal reticulocyte counts. The experience has been overwhelmingly positive and patients and families lives are being transformed in practice. With good adherence to HU therapy, no patient failed to respond either in haematological parameters or clinical symptoms. Good adherers now have fewer admissions to hospital; 0.90 days/patient/year compared to poor adherers 6.3 days/patient/year (p <0.0001) and there is an obvious improvement in growth of patients once they are established on therapy. We now have many children who have forgotten what sickle pain feels like, and enjoy improved school attendance and more active lives. Some patients even play competitive sports including cross country running, which was unheard of before HU therapy. No patient had to discontinue therapy due to any toxicity. No patient developed a high transcranial Doppler or proteinuria, and in two patients who had proteinuria at commencement of HU therapy, this has resolved. HU therapy has been so successful that we now have only one patient with sickle cell disease in our practice of 70 patients who is on a transfusion programme. Our next goals are to expand the HU programme to the rest of our patients and to increase the speed at which we achieve maximum tolerated doses. Our focus can then be on initiatives to improve adherence since our data indicate that adherence to therapy is critical. With good HU therapy adherence no patient failed to respond and therefore we envisage a minor role for transfusion programmes and BMT in the future. Our goal is also to disseminate this overwhelmingly positive experience to treating professionals, patients and families in the UK with Sickle Cell Disorder. Figure 1. Figure 1. Disclosures No relevant conflicts of interest to declare.
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Moses, Yilleng T., Sweta Bastia, Niharika Kumar, and Yatendra S. Chaudhary. "Surface Modification of Nickel Titanate Nanocubes with Ultra‐small Palladium and Platinum Nanocrystals to Promote Solar Hydrogen Generation under Visible Light." ChemistrySelect 8, no. 37 (October 4, 2023). http://dx.doi.org/10.1002/slct.202301990.
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AbstractModification of nickel titanate nanocubes with metal nanocrystals is a viable approach to build a Schottky heterojunction for efficient hydrogen generation. The deconvoluted XPS spectrum of Pt 4 f (peaks at 72.0 and 75.5 eV corresponding to Pt° and Pt2+) and Pd 3d3/2 (335.4 and 336.7 eV corresponding to Pd° and Pd2+) and presence of lattice fringes in HRTEM at 2.19 Å of Pd°, reveal the formation of heterojunction in Pd−NiTiO3 and Pt−NiTiO3 nanocubes. The solar hydrogen generation investigation exhibits 2‐fold enhancement in HER (130 and 165 μmol g−1 h−1 while using Pt−NiTiO3 and Pd−NiTiO3, respectively) than that of bare NiTiO3 (88 μmol g−1 h−1). The creation of heterojunctions between titanates and metal nanoparticles, facilitating efficient transport of photo‐generated electron to empty or partially filled d or f orbitals of metals, thereby lowering electron‐hole recombination rate, as revealed by shorter average lifetime 29 ns (Pd−NiTiO3) than 64 ns (NiTiO3). Further, the unison of faster charge transfer kinetics as revealed by the Nyquist plot, more negative flatband potential (Efb −0.3 vs. RHE) leading to appropriate band bending, reduced overpotential requirement, higher oxygen vacancies (19.46 %) and uniform dispersion of metal atoms on NiTiO3 surfaces that are acting as trapping centers etc. are enabling improved hydrogen generation in the case of Pd−NiTiO3.
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Prusty, Meenakhi, Debashish Swain, M. A. Alim, Monika Ray, and Debadatta Sethi. "Effect of Integrated Nutrient Management on Yield, Economics and Post-harvest Soil Properties of Sweet Corn Grown under Mid-Central Table Land Zone of Odisha." International Journal of Plant & Soil Science, April 16, 2022, 55–61. http://dx.doi.org/10.9734/ijpss/2022/v34i1430990.
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Sweet corn (Zea mays var. saccharata), popularly known as sugar corn or pole corn is a specialty maize having high sugar content at milk or early dough stage. As the corn is considered as an exhaustive crop, requires more nutrient, so integrated nutrient management practices play an important role in sustaining productivity of sweet corn. A field experiment was conducted during 2019 and 2020 in order to study the effect of integrated nutrient management on sweet corn yield and post harvest soil properties. Different growth parameters like plant height (206 cm), cob length (28.5 cm), cob girth (16.43 cm), no of seed rows per cob (18.80), no of grains per row (47.55) and green cob wt. (335.43g) were found highest in integrated package where bio fertilizer consortia, B and Zn were applied along with STD fertilization (T6). Total harvested yield of sweet corn including stover (2.58 to 2.98 t ha-1) and kernel (1.33 to 2.37t ha-1) varied from 3.91 to 5.35 t ha-1 in different treatments and was observed highest in T6 (5.35 t ha-1). Harvest index (44.29%), B: C ratio (3.15) and 1000 kernel weight (198.90 g) was also recorded highest in treatment T6. The post- harvest soil properties were also recorded highest in T6 where bio fertilizer consortia, B and Zn were applied along with STD fertilization in the INM package.
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Naik, D. Vijay Kumar, B. V. Bhaskara Reddy, Akkari Srividhya, R. Sarada Jayalakshmi Devi, L. Prasanthi, and Lakshminarayana R. Vemireddy. "Quantitative Trait Loci (QTL) Detection and Validation of Linked Markers Associated with Yellow Mosaic Virus Resistance in Urdbean [Vigna mungo (L.) Hepper] in Andhra Pradesh." Indian Journal Of Agricultural Research, Of (April 30, 2022). http://dx.doi.org/10.18805/ijare.a-5895.
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Background: The YMD is one of the serious viral diseases in blackgram and is being transmitted by whitefly (Bemisia tabaci). The development of YMV resistant blackgram varieties is one of the important aspects for sustainable blackgram production. Marker assisted selection and genetic transformation could be utilized in developing YMV resistant blackgram genotypes. Methods: We attempted to map the QTLs governing YMV resistance in blackgram employing parents i.e., PBG32 (susceptible) and PU31 (resistant). Parental polymorphic studies were conducted using 147 SSR markers and genotyping and phenotyping data were used for QTL mapping. The markers, CEDG097 and CEDG172 that flanked to qYMV1 QTL were validated in 25 blackgram genotypes. Result: SSR markers showed 16% polymorphism between the parents. By using F2 genotypic data, genetic linkage map was constructed and total genetic map length observed was 335.47 cm. Single QTL (qYMV1) for YMV tolerance was detected and located between markers CEDG097 and CEDG172 with LOD score value of 2.76. The PVE by qYMV1 is 13.10% and the QTL is tightly linked (0 cM) to the left flanking marker CEDG97, which denotes a major QTL. Genotyping of the 25 known blackgram genotypes employing CEDG097 and CEDG172 markers, CEDG097 showed 91% linkage in known resistant and susceptible varieties to the YMV disease reaction and CEDG172 exhibited 74% linkage in known varieties to the YMV disease reaction. The resistance alleles (PU31 allele) of both markers i.e. CEDG097 and CEDG172 were recorded in VBN7, LBG922, LBG933 and TBG130-1 hence, these genotypes can be considered as potent YMV resistant varieties and also can be used as donor parents in resistance breeding programmes.
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Banwarth, M. R., K. L. DeAtley, C. A. Gifford, T. K. Schohr, and Z. D. McFarlane. "Bull selection and management in extensive rangeland production systems of California: A producer survey." Translational Animal Science, October 5, 2022. http://dx.doi.org/10.1093/tas/txac138.
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Abstract California’s approximately 660,000 head of beef cattle are highly dependent on range bulls used to produce offspring that can perform across the state’s diverse ecological regions. Bulls need to be functional on rugged coastal landscapes, rolling foothills, deserts, and in high-elevation terrain. Few data exist that indicate factors related to selection, maintenance, and longevity of bulls used in rangeland landscapes. Objectives herein, were to assess factors influencing bull purchasing, management, and culling decisions of California beef producers. Surveys were mailed to the California Cattlemen’s Association membership (n = 1,410) with ~ 16% response rate (n = 227). Mean age and years of bull selection experience of respondents was 61 ± 1 years and 27 ± 1 years, respectively. Respondents managed cattle on a total of 694,949 ha of owned, private leased, and leased public rangelands in California and surrounding states. Cow-calf herd size was 333 ± 92 head and bull battery averaged 18 ± 2 head with average bull longevity of 5 ± 1.3 years. The average price paid for bulls in the last 2 years was $5007 ± 163.33, while the highest price paid in the last 5 years was $7291 ± 335.40. Survey responses were used to define current factors driving management after purchase and for subsequent breeding seasons. After bull purchase, 48% of producers turned bulls out directly with females, while 52% held bulls until the following breeding season. Additionally, most producers (70%) did not manage bulls to reduce condition after purchase. Semen quality analysis, a major component of a breeding soundness exam, was evaluated annually by 45% of respondents, while 20% of respondents never evaluated semen quality. Respondents indicated bull age (35%) and structural soundness (29%) as the most common factors for culling bulls. This research shows that despite the variability in operation demographics, there were similarities in beef bull selection and management across the state. Additionally, these data suggest the need for additional research focused on bull selection and management to maximize producer investment in reproduction.
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Eckerstrom, F., V. E. Hjortdal, M. Dellborg, P. Eriksson, and Z. Mandalenakis. "Mortality in patients with Ebstein anomaly: a two-country, population-based cohort study including 530 patients." European Heart Journal 43, Supplement_2 (October 1, 2022). http://dx.doi.org/10.1093/eurheartj/ehac544.1813.
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Abstract Background Low birth prevalence and referral bias constitutes significant obstacles in extending our knowledge regarding the natural history of Ebstein anomaly (EA). Purpose In an extensive two-country register-based collaboration we aimed to investigate the survival in EA patients with respect to associated congenital cardiac malformations Methods Patients born in the period 1970–2017 and diagnosed with EA were identified in Danish and Swedish nationwide medical registries and subsequently merged. Each EA patient was matched by birth year and gender with ten controls without congenital heart disease from the general population. Cox proportional hazard regression model and Kaplan-Meier survival function were used to compute risk of mortality (hazard ratio) and survival. Follow-up started at birth and patients became risk at time of EA diagnosis. Results We included 530 patients and 5,300 matched controls; median follow-up was 10.5 years (interquartile range: 3.5–20.9). In the total EA cohort, 43% (n=228) underwent cardiac surgery, predominantly EA-related surgery (81%). Approximately half of the cohort had an isolated EA (n=248), 11% (n=57) had a concomitant atrial septal defect only, and 42% (n=225) other associated congenital cardiac malformations. The 35-year survival in patients with isolated EA was 93%, superior compared with patients with concomitant atrial septal defect (ASD) (83%) and patients with other associated congenital cardiac malformations (72%), Figure 1. Patients with isolated non-operated EA had a risk of mortality of 25.6 (95% confidence interval (CI): 9.0–72.6) compared with the general population. Correspondingly, the risk in patients with surgically managed isolated EA was 21.7 (95% CI: 3.9–118.5). Patients with non-operated EA and a concomitant ASD (only) revealed a 10-fold increased risk of mortality (95% CI: 1.5–75.1) compared with the general population. The risk of mortality was substantially higher in both non-operated and operated EA patients with other associated congenital cardiac malformations, HR of 106.3 (95% CI: 31.8–335.4) and 42.6 (95% CI: 18.5–97.8), respectively. Conclusions Concomitant congenital cardiac malformations are common in EA patients and have major influence on survival, irrespective of treatment pathway (surgical versus non-surgical). Nonetheless, isolated non-operated EA patients have a 25-fold increased risk of mortality compared with the general population. Interestingly, concomitant ASD in non-operated patients seems protective in terms of risk of mortality. Funding Acknowledgement Type of funding sources: Foundation. Main funding source(s): Novo Nordisk Foundation.