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Journal articles on the topic '330.322.54 (043)'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Rogers, Jonathan, Camarie Welgemoed, and Dorothy Gujral. "Does body mass index or subcutaneous adipose tissue thickness affect interfraction prostate motion in patients receiving radical prostate radiotherapy?" Journal of Radiotherapy in Practice 15, no. 4 (2016): 334–40. http://dx.doi.org/10.1017/s1460396916000364.

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AbstractAimIt is unclear whether body mass index (BMI) is a useful measurement for examining prostate motion. Patient’s subcutaneous adipose tissue thickness (SAT) and weight has been shown to correlate with prostate shifts in the left/right direction. We sought to analyse the relationship between BMI and interfraction prostate movement in order to determine planning target volume (PTV) margins based on patient BMI.Materials and methodsIn all, 38 prostate cancer patients with three implanted gold fiducial markers in their prostate were recruited. Height, mass and SAT were measured, and the ext

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Van der Heijde, D., L. S. Gensler, A. Deodhar, et al. "OP0105 EFFICACY AND SAFETY OF BIMEKIZUMAB IN ANKYLOSING SPONDYLITIS: 48-WEEK PATIENT-REPORTED OUTCOMES FROM A PHASE 2B, RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE-RANGING STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 68–69. http://dx.doi.org/10.1136/annrheumdis-2020-eular.323.

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Background:Bimekizumab (BKZ), a monoclonal antibody that selectively neutralises interleukin (IL)-17A and IL-17F, is a potential therapeutic option in ankylosing spondylitis (AS).Objectives:To report 48-week (wk) patient-reported outcomes (PROs) in patients (pts) with AS treated with BKZ in a phase 2b dose-ranging study (BE-AGILE;NCT02963506).Methods:Pts with active AS (Bath AS Disease Activity Index [BASDAI] ≥4; spinal pain ≥4 [0–10]), fulfilling modified New York criteria (central reading), and inadequate response/intolerance to NSAIDs were randomised according to the study design (Figure 1)

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Louhanepessy, Rebecca, Sushil Badrising, Vincent van der Noort, et al. "Clinical outcomes of a Dutch prospective observational registry of metastatic castration resistant prostate cancer (mCRPC) patients treated with radium-223 (Ra-223)." Journal of Clinical Oncology 37, no. 7_suppl (2019): 323. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.323.

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323 Background: In 2012 the ALSYMPCA study established a 3.6 month Overall Survival (OS) benefit of mCRPC patients treated with Ra-223 over placebo. To date clinical outcomes of Ra-223 treatment in a non-study population have not been prospectively evaluated. Methods: The ROTOR registry aimed to include 300 patients in 20 Dutch hospitals prior to Ra-223 treatment at the physician’s discretion. Clinical parameters collected included: positioning of Ra-223, Adverse Events (AE’s; CTCAE v4.03), Skeletal Related Events (SRE) and survival data. SRE was defined as radiotherapy to a bone metastasis, a

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Matevosyan, Karén, Christopher Madden, Fleur M. Aung, et al. "Management of Warfarin Associated Intracranial Hemorrhage with a 3-Factor Prothrombin Complex Concentrate and Low Dose Recombinant Factor VIIa." Blood 112, no. 11 (2008): 3397. http://dx.doi.org/10.1182/blood.v112.11.3397.3397.

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Abstract Background: Intracranial hemorrhage (ICH) is a serious complication of warfarin therapy. Plasma infusion is the current standard of care in the US, even though most guidelines recommend prothrombin complex concentrate (PCC) as the preferred therapy; PCC has several advantages over plasma including no ABO blood type requirement, no lengthy thawing and infusion process, and a very small volume of virally inactivated pure vitamin K-dependent factors (VKDF) content that causes neither volume overload nor TRALI. Ideal PCC should contain adequate amounts of all VKDF (4-factor). As our group

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Jensky-Squires, Nicole E., Christina M. Dieli-Conwright, Amerigo Rossuello, David N. Erceg, Scott McCauley, and E. Todd Schroeder. "Validity and reliability of body composition analysers in children and adults." British Journal of Nutrition 100, no. 4 (2008): 859–65. http://dx.doi.org/10.1017/s0007114508925460.

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We tested the validity and reliability of the BioSpace InBody 320, Omron and Bod-eComm body composition devices in men and women (n 254; 21–80 years) and boys and girls (n 117; 10–17 years). We analysed percentage body fat (%BF) and compared the results with dual-energy X-ray absorptiometry (DEXA) in adults and compared the results of the InBody with underwater weighing (UW) in children. All body composition devices were correlated (r 0·54–0·97; P ≤ 0·010) to DEXA except the Bod-eComm in women aged 71–80 years (r 0·54; P = 0·106). In girls, the InBody %BF was correlated with UW (r 0·79; P ≤ 0·

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Van der Heijde, D., A. Deodhar, L. S. Gensler, et al. "POS0226 BIMEKIZUMAB LONG-TERM SAFETY AND EFFICACY IN PATIENTS WITH ANKYLOSING SPONDYLITIS: 3-YEAR RESULTS FROM A PHASE 2B STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 332–33. http://dx.doi.org/10.1136/annrheumdis-2021-eular.156.

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Background:Bimekizumab (BKZ), a monoclonal antibody that selectively inhibits interleukin (IL)-17A and IL-17F, has demonstrated clinical efficacy and safety in patients with ankylosing spondylitis (AS) treated over a period up to 96 weeks.1,2Objectives:To report 3-year interim safety and efficacy of BKZ in patients with active AS from a phase 2b dose-ranging study (BE AGILE; NCT02963506) and its ongoing open-label extension (OLE; NCT03355573).Methods:BE AGILE study design has been described previously.1 Patients treated with BKZ 160 mg or 320 mg every 4 weeks (Q4W) at Week 48 in BE AGILE were

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Тулегенова, И. М., М. Т. Копбаева, Б. А. Омарова та А. Д. Сагатбаева. "ИЗУЧЕНИЕ МОРФОЛОГИИ КОРНЕВЫХ КАНАЛОВ ПЕРВЫХ ПРЕМОЛЯРОВ ВЕРХНЕЙ ЧЕЛЮСТИ У КАЗАХСКОЙ ПОПУЛЯЦИИ С ПОМОЩЬЮ КОНУСНО-ЛУЧЕВОЙ КОМПЬЮТЕРНОЙ ТОМОГРАФИИ". Farmaciâ Kazahstana, № 4 (26 вересня 2024): 111–18. http://dx.doi.org/10.53511/pharmkaz.2024.60.51.013.

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Глубокое понимание морфологии корневых каналов и сложности их системы имеет решающее значение для достижения успешных результатов лечения в эндодонтии. Точная диагностика и планирование лечения основаны на выявлении и учете уникальной анатомии каждого зуба. Обладая обширными знаниями о морфологии корневых каналов, врачи могут предвидеть и подготовиться к потенциальным трудностям, с которыми они могут столкнуться во время лечения. Цель исследования - проанализировать конфигурацию корневых каналов первых премоляров верхней челюсти у лиц казахской национальности с помощью конусно-лучевой компьюте

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Waikel, Rebekah L., Amna A. Othman, Tanviben Patel, et al. "Recognition of Genetic Conditions After Learning With Images Created Using Generative Artificial Intelligence." JAMA Network Open 7, no. 3 (2024): e242609. http://dx.doi.org/10.1001/jamanetworkopen.2024.2609.

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ImportanceThe lack of standardized genetics training in pediatrics residencies, along with a shortage of medical geneticists, necessitates innovative educational approaches.ObjectiveTo compare pediatric resident recognition of Kabuki syndrome (KS) and Noonan syndrome (NS) after 1 of 4 educational interventions, including generative artificial intelligence (AI) methods.Design, Setting, and ParticipantsThis comparative effectiveness study used generative AI to create images of children with KS and NS. From October 1, 2022, to February 28, 2023, US pediatric residents were provided images through

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Suichi, Tomoki, Sonoko Misawa, Minako Beppu, et al. "Prevalence, clinical profiles, and prognosis of POEMS syndrome in Japanese nationwide survey." Neurology 93, no. 10 (2019): e975-e983. http://dx.doi.org/10.1212/wnl.0000000000008062.

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ObjectiveTo elucidate current epidemiological, clinical profiles, and treatment of polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome.MethodsWe conducted a nationwide survey in 2015 using an established epidemiologic method. Data processing sheets were sent to all neurology and hematology specialist departments throughout Japan to identify patients with POEMS who were seen between April 2012 and March 2015.ResultsThe estimated number of patients with POEMS was 392 (95% confidence interval [CI] 320–464), and the prevalence was 0.3 per 100,000. Detailed cl

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He, Xin, Kyriakie Sarafoglou, Patricia Y. Fechner, et al. "Changes in Adrenal and Gonadal Androgens After 14-Day Treatment With CRF1 Receptor Antagonist, Crinecerfont (NBI-74788), in Men With Classic 21-Hydroxylase Deficiency." Journal of the Endocrine Society 5, Supplement_1 (2021): A78. http://dx.doi.org/10.1210/jendso/bvab048.157.

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Abstract Background: Congenital adrenal hyperplasia due to classic 21-hydroxylase deficiency (21OHD) causes cortisol insufficiency and androgen excess. A phase 2 trial of crinecerfont, a CRF1 receptor antagonist, in 18 adults with 21OHD showed prominent decreases in ACTH, 17-hydroxyprogesterone, and androstenedione (A4), and in women, testosterone (T), after 14 days of treatment. In men with 21OHD, T derives from both adrenals and testes; in poor disease control, A4/T ratio is elevated due to disproportionately increased adrenal A4 production and decreased testicular T production. We sought to

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Azhar, Ahsan, Sriram Yennu, Aashraya Ramu, et al. "Referral patterns and characteristics of uninsured versus insured patients referred to the outpatient supportive care center (SCC) at a comprehensive cancer center." Journal of Clinical Oncology 34, no. 26_suppl (2016): 116. http://dx.doi.org/10.1200/jco.2016.34.26_suppl.116.

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116 Background: Multiple barriers exist in providing quality palliative care to low-income patients with cancer. Such disparities may negatively influence effective management of symptoms including pain. Our objective was to compare referral patterns and characteristics (level of symptom distress) of uninsured vs insured patients. Methods: We reviewed randomly selected charts of 100 Indigent (IND) and 100 Medicaid (MC) patients and compared them with a random sample of 300 patients with insurance (INS) referred during the same time period (1/2010 to 12/2014) to our SCC. Data was collected for

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Pislegina, S. S., and S. A. Chetvertnykh. "NEW VARIETY OF FIELD PEAS VYATICH." AGRO-INDUSTRIAL TECHNOLOGIES OF THE CENTRAL RUSSIA 18, no. 4 (2020): 64–71. http://dx.doi.org/10.24888/2541-7835-2020-18-64-71.

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The article provides a brief economic and biological characteristics of a new variety of field peas Vyatich, transferred to the State variety testing in 2020. The variety was created by individual selection from the hybrid population of Kazanets x K-3283. According to morphological characteristics, Vyatich belongs to the varieties of the mustachioed morphotype. The stem is simple, medium length (45-120 cm), purple flowers, inflorescence-2-3 axillary brush flowers. Seeds are greenish-brown with a purple speck, medium-small with a fused peduncle (weight of 1000 seeds 140-170 g). The variety is m

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Müller, Martin C., Jorge Cortes, Dong-Wook Kim, et al. "Dasatinib Efficacy in Patients with Chronic Myeloid Leukemia in Chronic Phase (CML-CP) and Pre-Existing BCR-ABL Mutations." Blood 112, no. 11 (2008): 449. http://dx.doi.org/10.1182/blood.v112.11.449.449.

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Abstract Dasatinib (SPRYCEL®) is an effective BCR-ABL inhibitor that is 325-fold more potent than imatinib and 16-fold more potent than nilotinib in vitro against unmutated BCR-ABL. Across a series of phase II and III trials, dasatinib has demonstrated durable efficacy in patients with CML following resistance, suboptimal response, or intolerance to imatinib. BCR-ABL mutations are an important cause of imatinib failure and suboptimal response. Here, the efficacy of dasatinib in patients with CML-CP who had baseline BCR-ABL mutations following imatinib treatment was analyzed using data from thr

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Galbreath, Melyn, Bill Campbell, Paul La Bounty, et al. "Effects of Adherence to a Higher Protein Diet on Weight Loss, Markers of Health, and Functional Capacity in Older Women Participating in a Resistance-Based Exercise Program." Nutrients 10, no. 8 (2018): 1070. http://dx.doi.org/10.3390/nu10081070.

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Resistance training and maintenance of a higher protein diet have been recommended to help older individuals maintain muscle mass. This study examined whether adherence to a higher protein diet while participating in a resistance-based exercise program promoted more favorable changes in body composition, markers of health, and/or functional capacity in older females in comparison to following a traditional higher carbohydrate diet or exercise training alone with no diet intervention. In total, 54 overweight and obese females (65.9 ± 4.7 years; 78.7 ± 11 kg, 30.5 ± 4.1 kg/m2, 43.5 ± 3.6% fat) w

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Duarte, Rafael F., Carmen Canals, Francesco Onida, et al. "Allogeneic Hematopoietic Cell Transplantation for Patients With Mycosis Fungoides and Sézary Syndrome: A Retrospective Analysis of the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation." Journal of Clinical Oncology 28, no. 29 (2010): 4492–99. http://dx.doi.org/10.1200/jco.2010.29.3241.

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PurposeTo analyze the outcome of allogeneic transplantation for mycosis fungoides and Sézary syndrome (MF/SS) in terms of nonrelapse mortality (NRM), relapse/progression (REL), progression-free survival (PFS), and overall survival (OS) and to identify factors associated with the outcome.Patient and MethodsSixty patients with MF (n = 36) and SS (n = 24) who received a first allogeneic hematopoietic cell transplantation (HCT) from a matched related (mRD; n = 45) or unrelated donor (mUD; n = 15) between 1997 and 2007 and who were registered in the European Group for Blood and Marrow Transplantati

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Schwitzguebel, Adrien J., Frank C. Kolo, Jérôme Tirefort, et al. "Efficacy of Platelet-Rich Plasma for the Treatment of Interstitial Supraspinatus Tears: A Double-Blinded, Randomized Controlled Trial." American Journal of Sports Medicine 47, no. 8 (2019): 1885–92. http://dx.doi.org/10.1177/0363546519851097.

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Background: The benefits of platelet-rich plasma (PRP) for the treatment of rotator cuff tears remain inconclusive, as it is administered either as an adjuvant to surgical repair or as a primary infiltration without targeting the index lesion, which could dilute its effect. Purpose: To determine whether PRP infiltrations are superior to saline solution infiltrations (placebo) at improving healing, pain, and function when injected under ultrasound guidance within isolated interstitial supraspinatus tears. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: In this single-c

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Zhai, W. D., M. H. Dai, B. S. Chen, et al. "Seasonal variations of sea–air CO<sub>2</sub> fluxes in the largest tropical marginal sea (South China Sea) based on multiple-year underway measurements." Biogeosciences 10, no. 11 (2013): 7775–91. http://dx.doi.org/10.5194/bg-10-7775-2013.

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Abstract. Based upon 14 field surveys conducted between 2003 and 2008, we showed that the seasonal pattern of sea surface partial pressure of CO2 (pCO2) and sea–air CO2 fluxes differed among four different physical–biogeochemical domains in the South China Sea (SCS) proper. The four domains were located between 7 and 23° N and 110 and 121° E, covering a surface area of 1344 × 103 km2 and accounting for ~ 54% of the SCS proper. In the area off the Pearl River estuary, relatively low pCO2 values of 320 to 390 μatm were observed in all four seasons and both the biological productivity and CO2 upt

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Dunning, K. R., L. K. Akison, D. L. Russell, R. J. Norman, and R. L. Robker. "428. Normal follicle growth and maturation in a three-dimensional in vitro culture system: follicular environment manipulation and assessment of oocyte outcomes." Reproduction, Fertility and Development 20, no. 9 (2008): 108. http://dx.doi.org/10.1071/srb08abs428.

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In vivo, the oocyte matures in a niche environment surrounded by somatic cells, and later in ovarian follicular development, by follicular fluid. Maternal diet influences the environment in which an oocyte matures but the mechanisms by which an altered metabolic profile, such as hyperinsulinemia, affects oocyte quality are not known. We investigated the use of a three dimensional follicle culture system allowing direct manipulation of the follicular environment thus circumventing systemic hormonal and metabolic effects. Secondary follicles (113.4 ± 1.02µm, n = 54) were isolated from mice at d1

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Buchan, Marissa, Melanie Guirette, Nancy Buderer, et al. "Equivalence of Ina, an AI-based nutrition platform, to human dietitians for counseling patients with cancer." Journal of Clinical Oncology 43, no. 16_suppl (2025): 12117. https://doi.org/10.1200/jco.2025.43.16_suppl.12117.

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12117 Background: Addressing nutritional issues in patients with cancer can reduce symptoms, shorten hospitalizations, enhance treatment adherence, and improve quality of life. However, most patients never receive nutrition counseling due to dietitian workforce shortages and healthcare access disparities. Advances in artificial intelligence (AI) and high rates of mobile device utilization among all demographics provide opportunities to expand reach. This study assessed if guidance from an expert-designed AI nutrition platform, “Ina”, is equivalent to that of human Oncology-Credentialed Registe

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MacMillan, Margaret L., Bruce R. Blazar, Todd E. Defor, et al. "Alternative Donor Hematopoietic Cell Transplantation for Patients with Fanconi Anemia." Blood 120, no. 21 (2012): 3081. http://dx.doi.org/10.1182/blood.v120.21.3081.3081.

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Abstract Abstract 3081 Hematopoietic cell transplantation (HCT) is the only proven curative therapy for the hematological abnormalities in patients with Fanconi anemia (FA). In the mid-1990s, survival after alternative donor (AD)-HCT was reported to be 18% with excessive rates of regimen-related toxicity, graft failure, graft-versus-host-disease (GVHD) and opportunistic infections (OI). Between 1990 and 2010, 127 FA patients underwent AD-HCT at the University of Minnesota using one of 5 consecutive, prospective phase I-II total body irradiation (TBI) containing clinical trials, representing th

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Oxenham, Chantal, Lewis Haddow, Cristian Sandulescu, et al. "P076 Five years of feedback for the newly diagnosed course – an evaluation of a peer-led intervention for people diagnosed with HIV." Sexually Transmitted Infections 93, Suppl 1 (2017): A41.3—A42. http://dx.doi.org/10.1136/sextrans-2017-053232.121.

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IntroductionNew diagnosis of HIV can be psychologically challenging, and presents an important opportunity to improve health literacy and engagement in care. Peer-led interventions are an effective means of providing support to people living with HIV (PLWH). We present an evaluation of a newly-diagnosed course (NDC) in London.MethodThe NDC, established in its current form in 2011, is accessible to ‘those recently diagnosed or struggling with diagnosis’. Providing a structured, peer-led, group-based, participatory programme delivered by experienced facilitators. NDC comprises 6 sessions (21 con

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Derda, E., E. Szymanska, M. Meglicka, A. Wiernicka, M. Osiecki, and J. Kierkus. "P395 The frequency of SARS-CoV-2 infection and the impact of vaccination on the disease morbidity in Polish pediatric patients with Inflammatory Bowel Disease treated with biologic therapies." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i825. http://dx.doi.org/10.1093/ecco-jcc/jjad212.0525.

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Abstract Background Little is known about morbidity of Covid-19 infection in pediatric patients with inflammatory bowel diseases (IBD) treated with biologic medications. The aim of this study was to evaluate the frequency of SARS-CoV-2 infection in children with IBD who received biologic therapies. Methods A prospective, observational cohort study to evaluate coronavirus disease 2019 (COVID-19) vaccination state, and its effect on the disease course among pediatric patients with IBD. The questionnaire included information concerning numbers of vaccine doses, patients’ medication and disease ac

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Messous, Salma, Imen Trabelsi, Khaoula Bel Haj Ali, et al. "Two-day versus seven-day course of levofloxacin in acute COPD exacerbation: a randomized controlled trial." Therapeutic Advances in Respiratory Disease 16 (January 2022): 175346662210997. http://dx.doi.org/10.1177/17534666221099729.

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Introduction: Duration of antibiotic treatment in acute exacerbation of COPD (AECOPD) is most commonly based on expert opinion. Typical administration periods range from 5 to 7 days. A 2-day course with levofloxacin was not previously assessed. We performed a randomized clinical trial to evaluate the efficacy of 2-day versus 7-day treatment with levofloxacin in patients with AECOPD. Methods and analysis: Patients with AECOPD were randomized to receive levofloxacin for 2 days and 5 days placebo ( n = 155) or levofloxacin for 7 days ( n = 155). All patients received a common dose of intravenous

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Alpizar-Rodriguez, D., F. Irazoque-Palazuelos, T. S. Rodriguez-Reyne, et al. "POS1242 FACTORS ASSOCIATED WITH MORTALITY IN PATIENTS WITH RHEUMATIC DISEASES AND COVID-19 IN MEXICO." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 904.1–904. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3342.

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Background:As of the 25th of January 2021, more than 150 thousand deaths as consequence of COVID-19 have been reported in Mexico [1]. Advanced age, male gender and comorbidities have been described as risk factors for severe disease and mortality in general population [2]. COVID-19 mortality in Mexican patients with rheumatic and musculoskeletal diseases (RMDs) is unknown.Objectives:To describe characteristics of Mexican patients with RMDs and COVID-19, and to analyse factors associated with mortality.Methods:The Global Rheumatology Alliance COVID-19 (GRA) physician reported registry, is an in

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Gustorff, Burkhard, Chris Poole, Herwig Kloimstein, Nicole Hacker, and Rudolf Likar. "Treatment of neuropathic pain with the capsaicin 8% patch: Quantitative sensory testing (QST) in a prospective observational study identifies potential predictors of response to capsaicin 8% patch treatment." Scandinavian Journal of Pain 4, no. 3 (2013): 138–45. http://dx.doi.org/10.1016/j.sjpain.2013.04.001.

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AbstractBackground and aimsPeripheral neuropathic pain (PNeP) is a chronic and disabling condition for which no predictors of response to treatment have yet been identified. Clinical studies show that while many patients with PNeP respond positively to treatment with the capsaicin 8% patch, others do not. This study used quantitative sensory testing (QST) to determine whether any patient characteristics can predict response to treatment with the capsaicin 8% patch.MethodsThis was a prospective, non-placebo-controlled, observational study. Patients used the Visual Analogue Scale (VAS) to assess

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Planchon, F., A. J. Cavagna, D. Cardinal, L. André, and F. Dehairs. "Late summer particulate organic carbon export and twilight zone remineralisation in the Atlantic sector of the Southern Ocean." Biogeosciences Discussions 9, no. 3 (2012): 3423–77. http://dx.doi.org/10.5194/bgd-9-3423-2012.

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Abstract. During the Bonus-GoodHope (BGH) expedition (Jan–Mar 2008) we studied the water column distribution of total 234Th and biogenic particulate Ba (Baxs) in the Atlantic sector of the Southern Ocean. The objective was to assess the export flux of particulate organic carbon (POC) from the surface to the mesopelagic twilight zone along a section between the Cape Basin and Weddell Gyre. Export production of POC was estimated from steady state and non steady state export fluxes of 234Th which were converted into POC fluxes, using the POC/234Th ratio of large (>53 μm) suspended particles, c

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Pascal, Laurent, Odile Beyne Rauzy, Sabine Brechignac, et al. "Highly Transfused MDS Patients Often Have Cardiac Iron Overload, as Shown by MRI Assessment." Blood 116, no. 21 (2010): 2906. http://dx.doi.org/10.1182/blood.v116.21.2906.2906.

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Abstract Abstract 2906 Background: Cardiac complications of transfusional iron overload are well documented in various inherited anemias. In regularly transfused MDS, the deleterious role of iron overload on cardiac disease is more disputed, due in particular to frequent concomitant causes of cardiac failure. Cardiac MRI T2* allows accurate and specific measurement of iron content. Methods: We prospectively evaluated in 4 centers of the GFM by standardized and transferable MRI methods both cardiac T2* according to Anderson (Eur Heart J. 2001Dec;22(23):2171-9) and liver iron content (LIC) accor

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Azpiri-López, J. R., I. J. Colunga-Pedraza, D. Á. Galarza-Delgado, et al. "AB0240 RHEUMATOID ARTHRITIS CLINICAL ACTIVITY IS NOT ASSOCIATED TO CARDIOVASCULAR RISK AS MEASURED BY TRADITIONAL RISK SCALES." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1304.2–1305. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3099.

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BackgroundRheumatoid arthritis (RA) patients have a higher cardiovascular risk (CVR) than the general population, being atherosclerotic cardiovascular disease the main cause of mortality [1]. Such increased could be explained by traditional CVR factors and chronic inflammatory state of disease. Clinical activity of disease, which is evaluated by DAS-28, is a parameter that denotes the current inflammatory status. [2]ObjectivesTo compare CVR, by six scales: ACC/AHA ASCVD 2013, Framingham lipids and BMI, SCORE2, QRISK3 and Reynolds risk score, according to clinical activity of RA patients using

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Sokolowska, Bozena, Aleksandra Nowaczynska, Ksenia Bykowska, et al. "JAK2 Mutational Status, Hemostatic Risk Factors and Thrombophilic Factors in Essential Thrombocythemia (ET) Patients." Blood 112, no. 11 (2008): 4542. http://dx.doi.org/10.1182/blood.v112.11.4542.4542.

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Abstract The recently discovered JAK 2 V617F activating tyrosine-kinase mutation has been found in 50–70% of Essential Thrombocythemia (ET) patients. Increased risk of thrombosis in patients with this mutation, especially homozygous for JAK2 V617F, has been reported. Other factors that increase the risk of thrombosis arising from ET itself include hereditary thrombophilic factors like antithrombin, protein C, and protein S deficiencies, the mutation of the prothrombin gene and the Leiden mutation of factor V, the MTHFR gene mutation, but also increase or decrease level of coagulation factors.

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Knapper, Steven, Robert K. Hills, James D. Cavenagh, et al. "A Randomised Comparison of the Sequential Addition of the FLT3 Inhibitor Lestaurtinib (CEP701) to Standard First Line Chemotherapy for FLT3-Mutated Acute Myeloid Leukemia: The UK Experience." Blood 124, no. 21 (2014): 3736. http://dx.doi.org/10.1182/blood.v124.21.3736.3736.

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Abstract Activating mutations of the receptor tyrosine kinase FLT3 are seen at diagnosis in one-third of younger adults with acute myeloid leukemia (AML) and are associated with an increased risk of relapse. FLT3 remains the subject of intense clinical interest as a therapeutic target. To date FLT3-targeted monotherapy has produced only transient clinical responses with no prospective trial producing an overall survival benefit. Here we report the results of the first randomised trial of a FLT3 inhibitor (Lestaurtinib, CEP701) given sequentially to chemotherapy as first line treatment for newl

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Baraliakos, X., E. Pournara, D. D. Gladman, P. J. Mease, S. Jahandideh, and L. Coates. "POS1110 PATIENT CLUSTERS IDENTIFIED BY MACHINE LEARNING: DATA FROM A POOLED ANALYSIS OF PHASE-3 TRIALS OF SECUKINUMAB IN PSORIATIC ARTHRITIS, ANKYLOSING SPONDYLITIS AND PSORIATIC ARTHRITIS WITH AXIAL MANIFESTATIONS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 879.1–879. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2975.

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BackgroundUniversally acceptable criteria to define axial psoriatic arthritis (PsA) are lacking. Machine learning (ML) algorithms can detect patterns from large clinical datasets and identify clusters with potential therapeutic or prognostic significance in PsA patients (pts) with axial manifestations.[1]ObjectivesTo identify pt clusters based on baseline (BL) demographics and clinical indicators to support characterisation of the axial PsA phenotype within the spondyloarthritis (SpA) spectrum.MethodsPooled BL demographics and clinical data of secukinumab (SEC)-treated pts from 10 Phase-3 stud

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Jillella, Anand, Prachi Karkhanis, Rashmi Sharma, et al. "A Multi-Center Prospective Study Utilizing a Simplified Treatment Algorithm Complemented By Expert Support Decreases Induction Mortality and Improves Survival in Acute Promyelocytic Leukemia (APL). Results of the APL Trial in Georgia, South Carolina and Neighboring States." Blood 128, no. 22 (2016): 2793. http://dx.doi.org/10.1182/blood.v128.22.2793.2793.

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Abstract Background: APL is a highly curable malignancy with reported survival above 90% in many co-operative group studies. However these spectacular results are not evident in the general population. US SEER data and other population based studies from Swedish Cancer Registry and Brazil showed that early deaths (ED) can be as high as 30%, leading to a considerably lower survival compared to clinical trials where ED is around 5-10%. Decreasing ED remains a global challenge and the highest priority at all leukemia treatment centers and will result in population wide survival in this most curab

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Pérez-Jacobo, Fernando, Luis Villela Villela, Edgar Velásquez-Vega, et al. "Phase I and Preliminary Results of a Phase II Study (TERAPLASCoV2) of Convalescent Plasma in Patients with Severe and Life-Threatening Pneumonia Caused By Sars-Cov-2." Blood 136, Supplement 1 (2020): 30–31. http://dx.doi.org/10.1182/blood-2020-140631.

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Introduction: The current coronavirus disease- 2019 (COVID-19) pandemic has caused a sudden increase in pneumonia cases, with a case-fatality rate of 10.9% in Mexico. Two inpatient groups have been defined, with different clinical evolution: cases of severe pneumonia and those with life-threatening disease (Acute respiratory distress syndrome [ARDS], invasive mechanical ventilation [IMV] requirement, and multiorgan involvement). Currently, there is no effective treatment. Convalescent plasma (CP) has been used to treat another viral infections and outbreaks since the last century. The rational

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Rugo, Hope S., Patrick Neven, Isabel Saffie, et al. "Abstract PD13-05: Alpelisib + fulvestrant in patients with PIK3CA-mutated, HR+, HER2— advanced breast cancer (ABC) who received chemotherapy or endocrine therapy (ET) as immediate prior treatment: BYLieve Cohort C primary results and exploratory biomarker analyses." Cancer Research 82, no. 4_Supplement (2022): PD13–05—PD13–05. http://dx.doi.org/10.1158/1538-7445.sabcs21-pd13-05.

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Abstract Introduction: Alpelisib (ALP), an inhibitor and degrader of phosphatidylinositol-3-kinase α (PI3Kα), + fulvestrant (FUL) demonstrated efficacy in PIK3CA-mutated, HR+, HER2- ABC in the phase 3 SOLAR-1 trial, which included only 20 patients (pts) with prior CDK4/6 inhibitor (CDKi) in the PIK3CA-mutated cohort. BYLieve (NCT03056755), a phase 2, open-label, 3-cohort noncomparative study, evaluates ALP + endocrine therapy (ET; FUL or letrozole [LET]) in pts with PIK3CA-mutated, HR+, HER2- ABC, progressing on/after prior therapies, including CDKi + ET. Cohorts A and B were restricted to pts

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Mariette, X., S. Borchmann, S. Aspeslagh, et al. "POS0824 CARDIOVASCULAR (CV) AND MALIGNANCY EVENTS IN THE FILGOTINIB (FIL) RHEUMATOID ARTHRITIS (RA) CLINICAL DEVELOPMENT PROGRAM UP TO 8.3 YEARS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 707.1–708. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1425.

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BackgroundFIL is a Janus kinase (JAK) 1 preferential inhibitor for the treatment of RA. Data from the ORAL Surveillance post-marketing study (NCT02092467) suggest that in patients with active RA aged ≥50 years with ≥1 CV risk factor, the risks of cancer and major adverse cardiovascular events (MACE) are higher with the pan-JAK inhibitor tofacitinib vs tumor necrosis factor inhibitors, with higher rates in those aged ≥65 vs <65 years.[1]ObjectivesTo assess the incidence of malignancies excluding non-melanoma skin cancer (NMSC), NMSC, MACE and venous thromboembolism (VTE) in patients treated

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Fiala, Mark A., Soo Park, Camille N. Abboud, et al. "Remobilization with G-CSF Is Less Effective Than the Initial Mobilization in Healthy Donors Undergoing Peripheral Blood Stem Cell Collection for Allogeneic Transplantation." Blood 124, no. 21 (2014): 850. http://dx.doi.org/10.1182/blood.v124.21.850.850.

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Abstract Background: The need to repeat peripheral blood stem cell (PBSC) mobilization and collection arises infrequently in healthy donors, but may be required due to insufficient initial collection, graft failure, or relapse of the recipient’s disease. Currently no published data exists on the efficacy of remobilization of healthy PBSC donors. Studies of remobilization in patients undergoing autologous transplantation (ASCT) have largely focused on the use of alternative mobilization agents such as chemotherapy or plerixafor. Boeve et al (Bone Marrow Transplant, 2004) reported that remobiliz

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Warmansyah, Jhoni, Afriyane Ismandela, Dinda Fatma Nabila, et al. "Smartphone Addiction, Executive Function, and Mother-Child Relationships in Early Childhood Emotion Dysregulation." JPUD - Jurnal Pendidikan Usia Dini 17, no. 2 (2023): 241–66. http://dx.doi.org/10.21009/jpud.172.05.

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Early childhood emotional dysregulation is critical in recognizing and preventing psychological well-being disorders, laying the groundwork for developing healthy emotional behaviors early on. This study aims to determine the direct influence of smartphone addiction, executive function, and the mother-child relationship on emotional dysregulation in early childhood in West Sumatra. This research method is a quantitative survey. The data collection technique in this research uses a questionnaire design on 309 parents who were selected using a simple random sampling method. This data processing

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Merryman, Reid W., Gabriela Spilberg, Patrizia Mondello, et al. "Interim Positron Emission Tomography (iPET) Assessed Using Deauville Score for Patients with Follicular Lymphoma Receiving First-Line Chemoimmunotherapy." Blood 136, Supplement 1 (2020): 37–38. http://dx.doi.org/10.1182/blood-2020-135919.

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Background: While most patients (pts) with follicular lymphoma (FL) have excellent outcomes with frontline chemoimmunotherapy (CIT), a subset of pts will experience early progression, which is associated with inferior survival. Earlier identification of high-risk FL pts could allow for intervention with novel treatments to forestall early progression. Current prognostic tools are imperfect, particularly for pts receiving bendamustine-based regimens, and novel biomarkers are needed. In Hodgkin lymphoma, interim positron emission tomography (iPET) evaluated based on Deauville score (DS) is highl

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Magnus, Dan, Santosh Bhatta, and Julie Mytton. "432 Establishing injury surveillance in emergency departments in Nepal: epidemiology and burden of paediatric injuries." Emergency Medicine Journal 37, no. 12 (2020): 825.2–827. http://dx.doi.org/10.1136/emj-2020-rcemabstracts.7.

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Aims/Objectives/BackgroundGlobally, injuries cause more than 5 million deaths annually. Children and young people are a particularly vulnerable group and injuries are the leading cause of death in people aged 5–24 years globally and a leading cause of disability.In most low and middle-income countries where the majority of global child injury burden occurs, systems for routinely collecting injury data are limited. There is a continuing need for better data on childhood injuries and for injury surveillance.The aim of our study was to introduce a hospital-based injury surveillance tool – the fir

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Vivek, K. Mukherjee, and V. Pokharkar Omkar. "Enzyme assisted extraction of polyphenols from Niger seed meal: a review." Biolife 4, no. 1 (2022): 121–29. https://doi.org/10.5281/zenodo.7312615.

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<strong>ABSTRACT</strong> The changing global economy and the food surpluses around the world have now stimulated an interest in seeking a new alternative crop especially an Oilseed Crop. Niger seed (<em>G. abyssinica)</em> is drawing commercial and academic attention because of its nutritional value, biological activities and excellent antioxidant properties. Niger seed has diverse application and hence this seed is of great industrial importance. Presence of polyphenols in Niger seed has been reported previously. Phenolic compounds, naturally found in plants are of considerable interest and

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M., N. Abubacker, and Mehala T. "Physico-chemical analysis of textile dye effluent using microbial consortia mediated degradation process." Biolife 5, no. 1 (2022): 60–67. https://doi.org/10.5281/zenodo.7359415.

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<strong>ABSTRACT</strong> Physico-chemical analysis of textile dye effluent have shown higher concentrations of total solids, total suspended solids, total dissolved solids, biological oxygen demand, chemical oxygen demand, dissolved oxygen, total hardness, carbonate, bicarbonate alkalinities, chloride, calcium, magnesium, sodium, sulphate, zinc, chromium, copper and lead was found to be above permissible levels of WHO standards which ensure the presence of pollutant overloaded in the textile effluent. Bacterial consortia was developed with <em>Bacillus subtilis </em>(NCBT 012), <em>Clostridiu

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Dibyendu, Talukdar. "Arsenic bioaccumulation and tolerance in terrestrial fern Ampelopteris prolifera (Retz.) Copel and aquatic fern, Azolla pinnata R. Br. are related to coordinated but differential responses of their antioxidant defense components." Biolife 4, no. 3 (2022): 460–70. https://doi.org/10.5281/zenodo.7321839.

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<strong>ABSTRACT</strong> Present study aims to analyze the arsenate bioaccumulation and antioxidant defense responses in fronds of terrestrial fern <em>Ampelopteris prolifera</em> (Retz.) Copel and an aquatic fern <em>Azolla pinnata</em> R. Br. Both the ferns were exposed to increased concentrations of sodium arsenate (As; 0, 20, 60, 100, and 160 mg L<sup>-1</sup>) with Hoagland nutrient solution. Shoot dry weight reduced in both ferns at 160 mg As L<sup>-1</sup> with higher decline in <em>A. pinnata</em> than <em>A. prolifera</em>. Fronds accumulated considerably higher As than roots but, co

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"EPIDEMIOLOGY OF TRAUMATIC SPINAL CORD INJURY IN SALAH-ALDEEN PROVINCE- IRAQ." International Journal of Medical Science in Clinical Research and Review 05, no. 05 (2022): 652–56. https://doi.org/10.5281/zenodo.7110273.

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Original Research Paper <strong>EPIDEMIOLOGY OF TRAUMATIC SPINAL CORD INJURY IN SALAH-ALDEEN PROVINCE- IRAQ</strong> <strong>Authors:</strong> <strong><sup>1</sup></strong><strong>Dr. Harith Ahmed Azeez, <sup>2</sup>Mozheer A. Abood, <sup>3</sup>Abeer Jassim Hamdan,<sup>4</sup>Dr. Zaid Al-Attar,<sup>5</sup>Dr. Husam H. Alkhafaji <sup>6</sup>Naseem Jaafar Sadiq, <sup>7</sup>Dr. Khalaf A. A.</strong> <em><sup>1,2,7</sup></em><em>Medical Rehabilitation Hospital, Tikrit</em> <em><sup>3</sup></em><em>Shaikh Zayed Hospital</em> <em><sup>4</sup></em><em>Al-Kindy College of Medicine / University of Ba

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AYANKOSO, Micheal Taiwo, Damilola Miracle OLUWAGBAMILA, and Olugbenga Samson ABE. "EFFECTS OF ACTIVATED CHARCOAL ON LIVESTOCK PRODUCTION: A REVIEW." Slovak Journal of Animal Science 56, no. 01 (2023): 46–60. http://dx.doi.org/10.36547/sjas.791.

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Aerts, R. (1997). Nitrogen partitioning between resorption and decomposition pathways: a trade-off between nitrogen use efficiency and litter decomposability? Oikos, 80(3), 603−406. Ahmedna, M., Marshall, W. E. & Rao, R. O. (2000). Granular Activated Carbons from Agricultural By-Products: Preparation, Properties, and Application in Cane Sugar Refining. LSU AgCenter: Bulletin Number 869. Albiker, D. & Zweifel, R. (2019). Pflanzenkohle im Futter oder in der Einstreu und ihre Wirkung auf die Stickstoffretention und Leistung von Broilern. Wissenschaftstagung Ökologischer Landbau. Kassel: S

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Ricci, Fabrizio, Nay Aung, Sabina Gallina, et al. "Cardiovascular magnetic resonance reference values of mitral and tricuspid annular dimensions: the UK Biobank cohort." Journal of Cardiovascular Magnetic Resonance 23, no. 1 (2020). http://dx.doi.org/10.1186/s12968-020-00688-y.

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Abstract Background Mitral valve (MV) and tricuspid valve (TV) apparatus geometry are essential to define mechanisms and etiologies of regurgitation and to inform surgical or transcatheter interventions. Given the increasing use of cardiovascular magnetic resonance (CMR) for the evaluation of valvular heart disease, we aimed to establish CMR-derived age- and sex-specific reference values for mitral annular (MA) and tricuspid annular (TA) dimensions and tethering indices derived from truly healthy Caucasian adults. Methods 5065 consecutive UK Biobank participants underwent CMR using cine balanc

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Kunanitthaworn, Natchaya, Oramai Mueangmo, Jutamad Saheng, et al. "Seroprevalence of hepatitis A virus antibodies among children and adolescents living in Northern Thailand: an implication for hepatitis A immunization." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-023-44643-0.

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AbstractThis cross-sectional study aimed to assess seroprevalence of hepatitis A virus (HAV) antibodies and identify factors associated with HAV seropositivity among children and adolescents aged 1–18 years who resided in Chiang Mai, Thailand. Sociodemographic characteristics, sanitation/hygiene, and history of HAV vaccination were collected. Anti-HAV IgG antibody was determined, and a level ≥ 1.0 S/CO defined HAV seropositivity. We enrolled 300 participants; median age 8.7 years, 54% male, and 13% overweight (BMI z-score: + 1 to + 2 standard deviation [SD]). Sixty-five participants (22%) were

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Kotnik, Katja Zdešar, Barbara Koroušić Seljak, Matej Gregorič, Gregor Jurak, and Petra Golja. "Questionable advisability of vitamin and mineral dietary supplement use in adolescents." BMC Nutrition 9, no. 1 (2023). http://dx.doi.org/10.1186/s40795-023-00768-z.

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Abstract Objective Present study aimed to assess potential health risk in Slovenian adolescents due to inadequate diet and/or dietary supplement (DS) use. Methods Data on DS use, micronutrient intake (24-h recall), eating habits (FFQ), body height and mass were collected within ACDSi (Analysis of Children’s Development in Slovenia) cross-sectional study conducted in 2014. Adolescents enrolled in first year of 15 secondary schools (average (SD) age: 15.4 (0.7) years, N = 342) were included in the sample. Results Adolescents’ use of DS (especially multivitamins ingested as a popular drink (60%),

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Chongmuenwai, Adisorn, Phumin Silathong, Tana Rattanakitkoson, Thanyaphon Sukpongthai, and Nualchavee Permthongchoochai. "Factors Affecting Postoperative Functional Outcomes in Older Patients with Hip Fractures at Maharat Nakhon Ratchasima Hospital." Journal of Southeast Asian Orthopaedics, February 21, 2023. http://dx.doi.org/10.56929/jseaortho-023-0175.

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Purpose: To identify prognostic factors for 6-month postoperative functional outcomes in older patients with hip fractures. Methods: This single-center prospective cohort study was conducted from January 2020 to December 2020. Patient factors and the preinjury Barthel index were collected from the patients at admission. The Barthel index was assessed again 6 months postoperatively to define functional outcomes. Minimal clinically important differences (MCIDs) between preinjury and 6-month functional outcomes were used to classify patients into satisfactory or unsatisfactory groups. The 6-month

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Gale, Chris, Don Sharkey, Kathryn E. Fitzpatrick, et al. "Characteristics and outcomes of neonates hospitalised with SARS-CoV-2 infection in the UK by variant: a prospective national cohort study." Archives of Disease in Childhood - Fetal and Neonatal Edition, November 15, 2023, fetalneonatal—2023–326167. http://dx.doi.org/10.1136/archdischild-2023-326167.

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ObjectiveNeonatal infection with wildtype SARS-CoV-2 is rare and good outcomes predominate. We investigated neonatal outcomes using national population-level data to describe the impact of different SARS-CoV-2 variants.DesignProspective population-based cohort study.SettingNeonatal, paediatric and paediatric intensive care inpatient care settings in the UK.PatientsNeonates (first 28 days after birth) with confirmed SARS-CoV-2 infection who received inpatient care, March 2020 to April 2022. Neonates were identified through active national surveillance with linkage to national SARS-CoV-2 testing

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