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Journal articles on the topic "324.218 3"
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Frommel, Monika. "§ 218: Straflos, aber rechtswidrig; zielorientiert, aber ergebnisoffen - Paradoxien der Übergangsregelungen des Bundesverfassungsgerichts." Kritische Justiz 26, no. 3 (1993): 324–35. http://dx.doi.org/10.5771/0023-4834-1993-3-324.
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Likutov, A. A., D. A. Mtvralashvili, M. A. Nagudov, O. M. Yugai, Yu E. Vaganov, S. V. Chernyshov, and O. A. Mainovskaya. "Factors limiting the endoscopic submucosal dissection in colorectal tumors." Koloproktologia 20, no. 2 (June 19, 2021): 50–56. http://dx.doi.org/10.33878/2073-7556-2021-20-2-50-56.
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Aim: to identify the risk factors for conversion of endoscopic submucosal dissection to abdominal surgery.Patients and methods: the prospective cohort study included 405 patients: 166 (40.9%) males and 239 (59.1%) females. The median age was 66 (59; 72) years old; the patients underwent endoscopic submucosal dissection of colorectal epithelial neoplasms.Results: the median size of the removed neoplasms was 3.0 (2.4; 4) cm, tumor was removed en bloc in 324/363 (89.2%) cases; and R0 resection margins were detected in 218/324 (67.3%) cases. Significant risk factors for conversion were: the tumor size ≥ 3.2 cm (OR 2.9, 95% CI 1.2–7.1, p = 0.017), lifting ≤ 3 mm (OR 41, 95% CI 15–105, p = 0.000002) and the tumor vascular pattern IIIa according Sano’s capillary pattern classification (OR 4.0, 95% CI 1.3–11.9, p = 0.013).Conclusion: endoscopic submucosal dissection is a safe way to remove colorectal neoplasms. However, the presence of conversion risk factors can influence the outcome of endoscopic treatment.
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Nieto, R., R. Quintana, E. Borba, L. Hernández, D. Fernández Ávila, L. F. Maurelli Torres, P. Alba, et al. "POS1519 BASELINE CHARACTERISTICS OF A LONGITUDINAL, MULTINATIONAL, MULTIETHNIC STUDY OF LUPUS PATIENTS, WITH OR WITHOUT LUPUS NEPHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (May 30, 2023): 1118.1–1120. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2738.
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BackgroundClinically evident kidney disease eventually occurs in up to one-half of SLE patients.ObjectivesTo describe sociodemographic, clinical, serological and treatment characteristics of a multicenter and multiethnic Latin American SLE cohort of patients with or without lupus nephritis (LN)MethodsGLADEL2.0 is an ongoing observational cohort. Patients were categorized according to renal involvement: Group I (LN never); II (prevalent renal involvement currently inactive); III (prevalent renal involvement, currently active) and IV (incident renal involvement). Demographic, clinical manifestations, treatments, disease activity were examined at baseline. A descriptive cross-sectional analysis was performed.ResultsA total of 991 SLE patients were included, 884 (89.2%) female and 656 (68.3%) Mestizos (Amerindian and European ancestry). Median (IQR) age at cohort entry was 35 (28-45) years and disease duration were 67 months (18-139). Patients with incident LN had a higher proportion of males, were younger, had shorter disease duration and were more frequently Mestizos. Pericarditis and anti-dsDNA were less frequent in group I and MMF in groups I and IV (Table 1). A predominance of class IV (49%) was evidenced in 510 patients in which a kidney biopsy was performed.ConclusionBaseline characteristics of GLADEL2.0 well characterized lupus patients’ cohort with or without LN are described with distinct demographic, clinical and laboratory patterns that will allow both centralized laboratory evaluation of urinary biomarkers and exploratory biomarker analyses including transcriptome and their impact on the outcome of these patients.Table 1.Sociodemographic and clinical characteristics and treatment at cohort entryVariableGroup I (n=393)Group II (n=213)Group III (n=224)Group IV (n=161)p-valueVariableGroup I (n=393)Group II (n=213)Group III (n=224)Group IV (n=161)p-valueFemale n%361/39391.9193/21390.6200/22489.3130/16180.70.002aEthnic group n%<0.001bAge (years)d39(30-48)38(30-48)30(25-37)33(25-40)<0.001cCaucasian106/37228.554/20826.037/22216.728/15917.6Disease duration (months)d77.1(32-146)106(52-187)64.4(25-130)3.0(0.7-26)<0.001Mestizo236/37263.4138/20866.3167/22275.2115/15972.3Education (years)d12.5(11-16)14(11-16)13(11-16)12(11-16)<0.001cIndigenous4/3721.12/2081.00/22202/1591.3Fevern%132/375(35.2)105/210(50.0)82/224(36.6)75/153(49.0)<0.001Afro-LAtin American26/3727.014/2086.718/2228.114/1598.8Discoid rashn%40/376(10.6)11/210(5.2)20/224(8.9)6/151(4.0)0.025Methylprednisolone bolusn%107/349(30.7)145/199(72.9)161/205(78.5)102/142(71.8)<0.001Pleuritisn%73/373(19.6)49/208(23.6)67/224(29.9)50/153(32.7)0.003Hydroxychloroquinen%321/365(87.9)182/205(88.8)194/220(88.2)121/136(89)0.985Pericarditisn%40/375(10.7)49/209(23.4)41/224(18.3)40/152(26.3)<0.001Azathioprinen%197/291(67.7)101/205(49.3)108/216(50.0)23/89(25.8)<0.001Anti-dsDNAn%231/361(64.0)167/204(81.9)194/216(89.8)134/150(89.3)<0.001Cyclophosphamide-IVn%47/289(16.3)129/202(63.9)139/214(65.0)38/89(42.7)<0.001Anti-Smn%88/324(27.2)47/167(28.1)73/187(39.0)60/128(46.9)<0.001Mycophenolaten%75/291(25.8)151/206(73.3)183/218(83.9)35/89(39.3)<0.001Positive Anti-Cardiolipinn%79/320(24.7)41/184(22.3)38/187(20.3)12/126(9.5)0.005Tacrolimusn%1/291(0.3)6/206(2.9)28/216(13.0)3/87(3.4)<0.001Positive Anti-B2GP1n%41/254(16.1)15/148(10.1)19/149(12.8)6/106(5.7)0.037Belimumabn%23/290(7.9)8/205(3.9)7/216(3.2)3/88(3.4)0.083Low C3n%228/367(62.1)158/205(77.1)193/218(88.5)137/150(91.3)<0.001Rituximabn%25/291(8.6)21/205(10.2)37/215(17.2)6/87(6.9)0.009Low C4n%244/367(66.5)155/203(76.4)193/217(88.9)134/150(89.3)<0.001SLEDAIc2(0-6)2(0-4)10(6-16)16(11-21.2)<0.001aChi-squared test was used.bFisher exact test was used.cKruskal-Wallis test was used.dMedian and IQRREFERENCES:NIL.Acknowledgements:NIL.Disclosure of InterestsRomina Nieto: None declared, Rosana Quintana: None declared, Eduardo Borba: None declared, Lucia Hernández: None declared, Diana Fernández Ávila: None declared, Laura Fernanda Maurelli Torres: None declared, Paula Alba: None declared, Florencia Bordon: None declared, Fernando Arizpe: None declared, Guillermo Berbotto: None declared, Rosa Serrano Morales: None declared, María Constanza Bertolaccini: None declared, Eduardo Kerzberg: None declared, Maria Gargiulo: None declared, Anabella Rodriguez: None declared, Vitalina Barbosa: None declared, Andrese Aline Gasparin: None declared, Fernando Cavalcanti: None declared, Laissa Alvino: None declared, Luciana parente costa seguro: None declared, Lucas de Oliveira Martins: None declared, Oscar Neira: None declared, loreto massardo: None declared, Gustavo Aroca Martínez: None declared, Ivana Nieto Aristizabal: None declared, PAUL ALEJANDRO MENDEZ PATARROYO: None declared, Antonio Iglesias Gamarra: None declared, Andrés Zúñiga: None declared, Olga Lidia Vera Lastra: None declared, Mario Pérez Cristóbal: None declared, Eduardo Martin-Nares: None declared, Luis Amezcua-Guerra: None declared, YELITZA CONCEPCION GONZALEZ BELLO: None declared, Jose Octavio Gonzalez Enriquez: None declared, Dionicio Ángel Galarza-Delgado: None declared, Carolina Vázquez: None declared, Marcelo Barrios: None declared, Magaly Alva: None declared, Cristina Reategui Sokolova: None declared, Ana Quiróz Alva: None declared, Teresandris Polanco Mora: None declared, Carina Pizzarossa: None declared, Martin Rebella: None declared, Maria Elena Crespo Espindola: None declared, ALVARO DANZA: None declared, Eloisa Bonfa: None declared, Graciela S Alarcon: None declared, Federico Zazzetti Employee of: Janssen Pharmaceutical Companies of Johnson & Johnson, Horsham, PA, USA, Ashley Orillion Employee of: Janssen Pharmaceutical Companies of Johnson & Johnson, Spring House, PA, USA, Urbano Sbarigia Employee of: Janssen Pharmaceutica NV, Beerse, BE, Guillermo Pons-Estel: None declared.
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Margolis, Eric, John Bennett, Marina Pavlova, Kenny Wong, Christopher Michael Pieczonka, Benjamin H. Lowentritt, Edward M. Uchio, and Melissa Conrad Stoppler. "Treatment decisions and outcomes for NCCN favorable intermediate-risk prostate cancer patients after receiving the 17-gene genomic prostate cancer score result." Journal of Clinical Oncology 39, no. 6_suppl (February 20, 2021): 218. http://dx.doi.org/10.1200/jco.2021.39.6_suppl.218.
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218 Background: Molecular assays are used to improve risk stratification in prostate cancer. This study determined how the 17-gene Genomic Prostate Score (GPS) assay guides treatment decisions in patients with NCCN favorable intermediate-risk prostate cancer. Methods: This retrospective study included 324 patients from 7 urology practices in the United States. All patients had NCCN favorable intermediate-risk prostate cancer, defined as <50% positive biopsy cores and only one of the following risk factors: grade group 2 (Gleason Score 3+4), clinical stage T2b-T2c, or PSA 10-20 ng/mL. All patients also had a GPS assay report dated May 2017 to April 2019. The GPS assay allows risk stratification into post-GPS very low-, low-, favorable intermediate-, unfavorable intermediate-, and high-risk groups, with higher GPS scores representing increased risk. Data were collected from patients' charts/electronic health records. The proportion of patients who selected active surveillance (AS) over immediate definitive treatment and AS, monotherapy, or multimodal therapy was calculated with 95% confidence intervals (CI) using the Clopper-Pearson method. Results: Patients comprised 79% with Gleason Score 3+4, 19% with PSA 10-20 ng/mL, and 2% with clinical stage T2b; median GPS result was 26. Post-GPS risk groups were 0%, 16%, 11%, 57%, and 16% very low-, low-, favorable intermediate-, unfavorable intermediate-, and high-risk groups respectively. Overall, 31% (95% CI 26%, 36%) of patients selected active surveillance (AS), with rate declining as post-GPS risk increased: 57% (95% CI 42%, 71%) selected AS in the post-GPS low-risk, 51% (95% CI 34%, 69%) in the post-GPS favorable intermediate-risk, 26% (95% CI 20%, 33%) in the post-GPS unfavorable intermediate-risk, and 6% (95% CI 1%, 16%) in the post-GPS high-risk group. Post-GPS unfavorable intermediate/high risk-patients were more likely to receive monotherapy than low/favorable intermediate-risk patients (high, 72%; unfavorable intermediate, 64%; favorable intermediate, 37%; and low, 37%); high-risk patients were more likely to receive multimodal therapy (high, 23%; unfavorable intermediate, 10%; favorable intermediate, 11%; and low, 6%). Median follow-up time was 18 months, and one prostate cancer-related metastasis and 2 deaths (neither prostate cancer-related) were reported. Complications (erectile dysfunction, urinary/bowel incontinence) were more common in treated than AS patients. AS persistence was 91% (95% CI 82%, 95%) at 12 months; patients discontinued AS due to disease progression (61%) or patient preference/unknown reasons (39%). Conclusions: The GPS result is associated with selection of AS and treatment intensity in this first examination of genomic classifiers in a cohort of prostate cancer patients with NCCN favorable intermediate-risk.
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Pittelkow, Merle-Marie, Ymkje Anna de Vries, Rei Monden, Jojanneke A. Bastiaansen, and Don van Ravenzwaaij. "Comparing the evidential strength for psychotropic drugs: a Bayesian meta-analysis." Psychological Medicine 51, no. 16 (October 8, 2021): 2752–61. http://dx.doi.org/10.1017/s0033291721003950.
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AbstractApproval and prescription of psychotropic drugs should be informed by the strength of evidence for efficacy. Using a Bayesian framework, we examined (1) whether psychotropic drugs are supported by substantial evidence (at the time of approval by the Food and Drug Administration), and (2) whether there are systematic differences across drug groups. Data from short-term, placebo-controlled phase II/III clinical trials for 15 antipsychotics, 16 antidepressants for depression, nine antidepressants for anxiety, and 20 drugs for attention deficit hyperactivity disorder (ADHD) were extracted from FDA reviews. Bayesian model-averaged meta-analysis was performed and strength of evidence was quantified (i.e. BFBMA). Strength of evidence and trialling varied between drugs. Median evidential strength was extreme for ADHD medication (BFBMA = 1820.4), moderate for antipsychotics (BFBMA = 365.4), and considerably lower and more frequently classified as weak or moderate for antidepressants for depression (BFBMA = 94.2) and anxiety (BFBMA = 49.8). Varying median effect sizes (ESschizophrenia = 0.45, ESdepression = 0.30, ESanxiety = 0.37, ESADHD = 0.72), sample sizes (Nschizophrenia = 324, Ndepression = 218, Nanxiety = 254, NADHD = 189.5), and numbers of trials (kschizophrenia = 3, kdepression = 5.5, kanxiety = 3, kADHD = 2) might account for differences. Although most drugs were supported by strong evidence at the time of approval, some only had moderate or ambiguous evidence. These results show the need for more systematic quantification and classification of statistical evidence for psychotropic drugs. Evidential strength should be communicated transparently and clearly towards clinical decision makers.
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Bianchi, Marta A., Francesca Scazzina, Daniele Del Rio, Silvia Valtueña, Nicoletta Pellegrini, Laura Franzini, Maria Luisa Callegari, et al. "Ability of a high-total antioxidant capacity diet to increase stool weight and bowel antioxidant status in human subjects." British Journal of Nutrition 104, no. 10 (June 28, 2010): 1500–1507. http://dx.doi.org/10.1017/s0007114510002424.
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There is limited knowledge about the possible effect of unabsorbed dietary antioxidants that reach the large intestine on bowel habits. The aim of the present study was to investigate whether a dietary recommendation directed to increase diet total antioxidant capacity (TAC) is able to affect gut function in human subjects. In this cross-over intervention, nineteen subjects followed a high-TAC (HT) and a low-TAC (LT) diet for 2 weeks, which were comparable for energy, macronutrient, total dietary fibre and alcohol contents. At the end of each intervention period, the 48 h stool output was recorded. In the faecal samples obtained from a subset of nine subjects, moisture, pH, ammonia content,LactobacillusandBifidobacteriumcounts, faecal water antioxidants and genotoxicity were measured. A 3 d weighed food record was used to assess the diet composition during HT and LT diet intake. Significant increases in the intake of TAC, vitamins E and C and phenolic compounds were observed during the HT diet intake. The higher intake of antioxidants led to increased 48 h stool output (324 (sd38) g in HTv. 218 (sd22) g in LT), and to higher TAC and total phenolic concentrations in faecal water. No significant variation in the other measured parameters was observed between the diets. In conclusion, a diet selected to raise the intake of dietary antioxidants is able to increase stool bulk and antioxidant content of faeces.
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Falchi, Lorenzo, Michael J. Keating, Susan Lerner, Xuemei Wang, Sara S. Strom, William G. Wierda, and Alessandra Ferrajoli. "Other Cancers in Patients with Chronic Lymphocytic Leukemia Requiring Therapy: Association with Prognostic Factors and Impact On Survival." Blood 120, no. 21 (November 16, 2012): 3896. http://dx.doi.org/10.1182/blood.v120.21.3896.3896.
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Abstract Abstract 3896 Chronic lymphocytic leukemia (CLL) is associated with an increased incidence of other cancers (OC). Potential risk factors for OC in CLL include immune disturbances, shared risk factors, genetic predisposition and chemotherapy. While reports on OC in patients with CLL have been typically descriptive in nature, detailed information regarding the clinical features of OC, relationship with the time of diagnosis of CLL, patient characteristics, prognostic factors and survival have been missing. We report an analysis of OC in pts with CLL requiring therapy, with a post therapy observation time of 5 years or longer. We reviewed our database and selected pts with CLL seen at our center who underwent treatment and who have a follow-up of at least 5 years after therapy. We studied pts with an OC either before or after the diagnosis and/or treatment of CLL and compared them with patients without OC. Richter's transformation of CLL was not considered an OC in this analysis. A total of 1,364 pts with CLL referred between 1963 and 2007 with a median follow up time of 8.2 years (range 5–28) were studied. Among these, we identified 324 pts (24%) with OC. Sixty-eight pts were diagnosed with >1 OC [2 OC (62 pts), 3 OC (4 pts) or 4 OC (2 pts)], for a total of 400 individual OC. Of the 324 pts with OC, OC preceded the diagnosis of CLL in 117 pts (36%), with a median time from OC to CLL of 80 (0–455) months, OC occurred after the diagnosis of CLL but before treatment in 49 pts (15%), with median time from CLL to OC of 22 (0–131) months. OC occurred after treatment of CLL in 158 pts (49%), with a median time from treatment to OC of 94 (0–304) months. The type, frequency and timing of OC are summarized in table 1. Clinical characteristics and traditional prognostic factors were not significantly different between pts with and without OC, with the exception of age, as pts with OC are older than pts without OC at the time of referral (median age: 60 vs 55 years, p<.0001). We next analyzed the distribution of the newer prognostic parameters in these two groups. Fifty-three % of pts with OC had unmutated IGHV genes, 65% were ZAP70+, 22% CD38+, 8% had del17p, 27% del11q, 22% +12, 20% negative FISH, and 23% del13q. Sixty-one % of pts without OC had unmutated IGHV genes, 58% were ZAP70+, 26% CD38+, 6% had del17p, 17% del11q, 22% +12, 26% negative FISH, and 29% del13q. A trend toward significance (p.07) for a higher incidence of del11q was observed in pts with OC. At the time of this analysis 536 (39%) pts have died and 828 (61%) are alive. One hundred seventy six/324 (54%) pts with OC are alive, vs 652/1040 (63%) pts without OC (p<.007). Median overall survival (OS) has not been reached in either pt group at a median follow up of 95 (61–284) months for pts with OC and 98 (61–340) months for pts without OC. Causes of death were: progression of CLL (99), CLL-related complications (121), OC (43), complications of stem cell transplant (16), events unrelated to CLL (39) and unknown causes (218). In pts with OC, the OC itself was the cause of death in 37%. Other causes of death were CLL/CLL-related complications in 44%, complications of stem cell transplant in 8%, and events unrelated to CLL in 11%. In contrast, in pts without OC CLL/CLL-related complications accounted for 83% of deaths, complications of stem cell transplant for 4%, and events unrelated to CLL for 13%. In conclusion, in pts with CLL requiring therapy and with post therapy follow up of >5 years, the incidence of OC is 24%. Among pts with OC, there is a trend for higher number of pts with del11q. In pts with OC, OC itself is a major cause of death, while the vast majority of deaths among pts without OC are caused by CLL or CLL-related complications. Table 1. Distribution of OC (1364 pts). Site of OC 1st case Total cases OC prior/at CLL OC after CLL After diagnosis After treatment NMSC1 124 144 41 26 77 PROSTATE 43 54 18 7 29 MELANOMA 26 34 16 2 16 BREAST 23 26 14 2 10 MDS/AML2 16 18 0 0 18 LUNG 14 21 0 1 20 NEUROENDOCRINE 3 6 1 0 5 HEAD AND NECK 12 16 3 2 11 UROTHELIAL CELL CANCERS 11 12 7 2 3 GI3 (including pancreas and liver) 10 18 4 3 11 KIDNEY 10 11 4 3 4 NHL4 and MM5 8 12 0 0 12 TESTIS/OVARY 6 6 4 0 2 THYROID 6 7 5 1 1 SARCOMAS 4 5 4 0 1 UTERUS 2 3 3 0 0 OTHERS6 6 7 3 0 4 TOTALS 324 400 127 49 224 1 non-melanoma skin cancers; 2 myelodysplastic syndrome/acute myeloid leukemia; 3 gastrointestinal; 4 non-Hodgkin's lymphoma; 5 multiple myeloma; 6 includes: brain, nasopharyngeal, penis carcinoma, mesothelioma, unknown primary. Disclosures: No relevant conflicts of interest to declare.
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Sung, Ki-Chul, Sarah H. Wild, and Christopher D. Byrne. "Resolution of Fatty Liver and Risk of Incident Diabetes." Journal of Clinical Endocrinology & Metabolism 98, no. 9 (September 1, 2013): 3637–43. http://dx.doi.org/10.1210/jc.2013-1519.
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Context: Fatty liver is associated with an increased risk of type 2 diabetes, but whether an increased risk remains in people in whom fatty liver resolves over time is not known. Objective: The objective of the study was to assess the risk of incident diabetes at a 5-year follow-up in people in whom: 1) new fatty liver developed; 2) existing fatty liver resolved, and 3) fatty liver severity worsened over 5 years. Design and Methods: A total of 13 218 people without diabetes at baseline from a Korean occupational cohort were examined at baseline and after 5 years, using a retrospective study design. Fatty liver status was assessed at baseline and follow-up as absent, mild, or moderate/severe using standard ultrasound criteria. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for incident diabetes at follow-up were estimated after controlling for multiple potential confounders. Results: Two hundred thirty-four people developed incident diabetes. Over 5 years, fatty liver resolved in 828, developed in 1640, and progressed from mild to moderate/severe in 324 people. Resolution of fatty liver was not associated with a risk of incident diabetes [aOR 0.95 (95% CIs 0.46, 1.96), P = .89]. Development of new fatty liver was associated with incident diabetes [aOR 2.49 (95% CI 1.49, 4.14), P < .001]. In individuals in whom severity of fatty liver worsened over 5 years (from mild to moderate/severe), there was a marked increase in the risk of incident diabetes [aOR 6.13 (2.56, 95% CI 14.68) P < .001 (compared with the risk in people with resolution of fatty liver)]. Conclusion: Change in fatty liver status over time is associated with markedly variable risks of incident diabetes.
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Giardini, Isabela, Katia Soares da Poça, Paula Vieira Baptista da Silva, Valnice Jane Caetano Andrade Silva, Deborah Santos Cintra, Karen Friedrich, Barbara Rodrigues Geraldino, Ubirani Barros Otero, and Marcia Sarpa. "Hematological Changes in Gas Station Workers." International Journal of Environmental Research and Public Health 20, no. 10 (May 20, 2023): 5896. http://dx.doi.org/10.3390/ijerph20105896.
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(1) Background: Benzene, toluene, and xylene isomers (BTX) are present in gasoline. Exposure to benzene may lead to the appearance of a series of signs, symptoms, and complications, which are characterized by benzene poisoning, which is an occupational disease. This study evaluated the presence of signs and symptoms related to occupational exposure and whether occupational exposure to BTX is associated with the development of hematological changes. (2) Material and Methods: This cross-sectional epidemiological study included 542 participants, in which 324 were gas station workers (GSWs) and 218 were office workers (OWs) with no occupational exposure to benzene. To characterize the type of exposure (exposed and not exposed), trans,trans-Muconic acid (tt-MA), Hippuric acid (HA), and Methylhippuric acid (MHA) were used as exposure biomarkers. The tt-MA analysis revealed that the GSWs had 0.29 mg/g of urinary creatinine and the OWs had 0.13 mg/g of urinary creatinine. For HA, the GSWs presented 0.49 g/g of creatinine while the OWs presented 0.07. MHA analysis revealed that the GSWs had 1.57 g/g creatinine and the OWs had 0.01 g/g creatinine. Occupation habits and clinical symptoms were collected by questionnaire and blood samples were analyzed for hematological parameters. The persistence of hematological changes was evaluated with three serial blood collections every 15 days followed by laboratory hematological analysis. A descriptive analysis by the Chi-square test method was performed to evaluate the association between occupational exposure to fuels and the occurrence of changes in hematological parameters. (3) Results: In the GSWs, the most described signs and symptoms were somnolence (45.1%), headache (38.3%), dizziness (27.5%), tingling (25.4%), and involuntary movement (25%). Twenty GSWs that presented hematological alterations performed serial collections fifteen days apart. In addition, these workers presented total leukocyte counts above the upper limit and lymphocyte counts close to the lower limit. Leukocytosis and lymphopenia are hematological alterations present in chronic benzene poisoning. (4) Conclusions: The results found an initial change in different hematological parameters routinely used in clinics to evaluate health conditions. These findings reveal the importance of valuing clinical changes, even in the absence of disease, during the health monitoring of gas station workers and other groups that share the same space.
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Shah, Jatin, Joan Blade, Pieter Sonneveld, Jesus San Miguel, Donghan Luo, Keith C. Lantz, Colin Lowery, Jean-Luc Harousseau, and Robert Z. Orlowski. "The Effect of Paraprotein Heavy Chain and Free Light Chain Types on the Efficacy of Pegylated Liposomal Doxorubicin + Bortezomib Versus Bortezomib Alone in Patients with Relapsed/Refractory Multiple Myeloma." Blood 112, no. 11 (November 16, 2008): 5190. http://dx.doi.org/10.1182/blood.v112.11.5190.5190.
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Abstract Background: Many factors influence the choice of salvage therapy in relapsed/refractory multiple myeloma (RRMM), including various disease characteristics such as light chain and heavy chain subtypes. Patients with light chain only myeloma are a biologically and phenotypically distinct subset of patients from those with IgG, IgA, IgM, or IgD disease. Evidence exists that the presence of different paraprotein heavy and light chain subtypes may affect treatment outcomes. We investigated the effect of the presence of paraprotein heavy and light chain types on the efficacy and safety of pegylated liposomal doxorubicin (PLD) + bortezomib (B) versus B alone based on the phase III randomized trial of PLD+B vs. B alone in RRMM, which demonstrated improved time to progression (TTP) with PLD+B (Orlowski, JCO 2007). Methods: Eligible patients were randomized to bolus IV B 1.3 mg/m2 on days 1, 4, 8, and 11 of each 3-week cycle (n=322) or to the same B regimen plus IV PLD 30 mg/m2 on day 4 (n=324) of each cycle. The subsets of patients with light chain and heavy chain multiple myeloma subtypes were analyzed retrospectively. Results: The presence of light chain myeloma was observed in 77 patients. Few patients had IgM/IgD subtype myeloma (4 and 6 patients, respectively), while the majority of patients had IgG (n=379) or IgA (n=265) subtypes. Time to disease progression (TTP) and complete response (CR) + partial response (PR) rates for PLD+B vs B alone in patients with light chain, IgG, and IgA myeloma subtypes are listed in the table. PLD+B B P valueb Hazard Ratioc a. Based on Kaplan-Meier product-limit estimates. b. Based on stratified Log-rank test. c. A hazard ratio >1 indicates an advantage for PLD+B. d. Cochran-Mantel-Haenszel test controlling for Beta2 microglobulin and response to initial treatment. Light chain, N 40 37 TTP, Median days (95% CI)a 276 (171, n/a) 117 (85, 173) .003 3.09 (1.42, 6.73) Total CR+PR, n/evaluable (%) 22/39 (56) 10/33 (30) .030d IgG subtype, N 182 197 TTP 282 (221, 331) 199 (170, 222) .002 1.67 (1.20, 2.31) Total CR+PR 70/173 (41) 81/194 (42) .915d IgA subtype, N 88 77 TTP 250 (218, n/a) 205 (177, 236) .506 1.22 (0.68, 2.18) Total CR+PR 46/79 (58) 39/72 (54) .723d Results showed that the combination of PLD+B had significant benefit over B alone in TTP (PLD+B led to longer TTP than B alone) for IgG paraprotein and light chain subtypes. Safety profiles for the 2 regimens in these subsets of patients with heavy or light chain myeloma were consistent with the known toxicities of the 2 agents used. Conclusions: These data demonstrate that the combination of PLD+B is an important treatment option in patients with RRMM. Patients with light chain only disease had the largest incremental benefit from the addition of PLD with an absolute increase in TTP of 159 days as well as an increase in the overall response rate from 30% to 56%.
Dissertations / Theses on the topic "324.218 3"
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Rodrigues, Filipe Martim Abreu. "Imparidades v.s. amortização do Goodwill : estudo de caso Air Liquide." Master's thesis, Instituto Superior de Economia e Gestão, 2020. http://hdl.handle.net/10400.5/21050.
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Mestrado em Contabilidade, Fiscalidade e Finanças EmpresariaisO goodwill é um tema que tem gerado bastante discussão na literatura. Enquanto que alguns autores defendem o atual método da imparidade, outros acham que este método não fornece informação relevante para os utilizadores das demostrações financeiras. Neste sentido, a UE emitiu a Diretiva 2013/34/UE que recomenda às empresas que adotem o método da amortização no que respeita à contabilização subsequente do goodwill. A Air Liquide aplica o método da imparidade no cálculo do seu goodwill. Este estudo tem como o objetivo estudar o impacto da alteração do método de contabilização do goodwill, para o método da amortização, nas demonstrações financeiras com base em dois cenários. O primeiro cenário consiste em atribuir uma vida útil de 10 anos a todo o goodwill, enquanto que no segundo cenário, o goodwill do segmento de negócio Gás tem uma vida útil de 40 anos e o restante goodwill uma vida de 20 anos. Uma vez que a empresa possui uma elevada percentagem do ativo representado por goodwill, a aplicação do método da amortização levou a uma redução materialmente relevante do ativo da empresa (-58,82% no cenário I e -20,66% no cenário II), devido à redução do valor do goodwill da empresa. A aplicação do método da amortização levou ainda a um aumento dos gastos de amortização o que gerou um impacto negativo nas demostrações financeiras da empresa. Os rácios financeiros e de rendibilidade foram afetados de forma negativa. No entanto, os rácios de Rendibilidade do Capital Próprio e ROA tiveram uma variação positiva.
Goodwill is a topic that has generated o lot of discussion in the literature. While some authors defend the current method of impairment, other believe that this method also lead to an increase in does not provide useful information for the users of financial statements. That said, the EU issued the Directive 213/14/EU which recommends companies to adopt the amortization method when doing the subsequent accounting for goodwill. Air Liquide applies the impairment method when accounting for goodwill. This study aims to analyze the impact of changing the method of accounting for goodwill, to the amortization method, on the financial statements based on two scenarios. On the first scenario all goodwill has a useful life of 10 years, while on the second scenario, all goodwill allocated to the business segment Gas has a useful life of 40 years and the remaining goodwill a useful life of 20 years. The company has a high asset percentage represented by goodwill and the application of the amortization method led to a material reduction in the company's asset (-58,82% on the scenario I and -20,66% on scenario II), due to the goodwill reduction. The application of the amortization method also led to an increase in the amortization expenses, which had a negative impact on the company's financial statements. The financial and profitability ratios were negatively affected. However, the Return of Equity and ROA ratios had a positive variation.
info:eu-repo/semantics/publishedVersion
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Schenk, Franz. "An Active Domain Node Architecture for the Semantic Web." Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-0006-B3B7-3.
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VALENTE, LAURA. "GREGORIO NAZIANZENO Eij" ejpiskovpou" [carm. II,1,13. II,1,10] Introduzione, testo critico, commento e appendici." Doctoral thesis, 2018. http://hdl.handle.net/11393/251619.
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Invitato a Costantinopoli da una delegazione nicena, che ne chiedeva l’intervento a sostegno della comunità ortodossa locale, Gregorio di Nazianzo accantonò il desiderio di dedicarsi alla vita contemplativa e si recò nella Neja ÔRwvmh: non poteva certo immaginare che negli anni trascorsi nella capitale (dagli inizi del 379 al luglio del 381) avrebbe conosciuto, a distanza di breve tempo, l’apice e il fallimento della sua attività politico-ecclestiastica. Alla guida di un piccolo gruppo di fedeli, radunati in una sala udienze privata ribattezzata Anastasia, Gregorio esercitò con impegno i suoi doveri pastorali, spendendosi soprattutto nella lotta dottrinale contro l’eresia ariana. L’elezione come vescovo della città, avvenuta per volere dell’imperatore Teodosio, rappresentò il riconoscimento dei meriti del Cappadoce nella restaurazione e nel consolidamento dell’ortodossia nicena, ma, allo stesso tempo, aprì la strada a una stagione tutt’altro che scevra di asprezze, destinata a lasciare amari ricordi nel cuore dell’autore. Chiamato a presiedere il concilio episcopale del 381, indetto con l’obiettivo di risolvere lo scisma antiocheno e condannare le eresie del tempo, il Nazianzeno sperimentò sulla propria i conflitti interni ed i giochi di potere cui si era ridotto l’episcopato. Alla malattia, che debilitò il fisico dell’autore e ne ostacolò la partecipazione a svariate attività pubbliche, si aggiunse l’ostilità dei colleghi, in particolare di alcuni vescovi egiziani, che contestarono la legittimità della sua elezione sul seggio di Costantinopoli, in quanto già vescovo nella sede di Sasima. Stanco e malato, amareggiato dai continui scontri e dall’ennesimo attacco subito dagli avversari, Gregorio decise di farsi da parte e, rassegnate le dimissioni dalla cattedra episcopale, lasciò Costantinopoli, senza neppure aspettare la conclusione del sinodo. Nella natia Cappadocia, lontano fisicamente dal clima tumultuoso e dai dispiaceri della capitale, ma turbato dalle calunnie e dalle ingiustizie subite da coloro che riteneva amici, il Nazianzeno sfogò le proprie delusioni nella scrittura poetica. All’esperienza costantinopolitana e in particolare al contesto delle dimissioni dalla cattedra vescovile fanno riferimento i carmi oggetto di questa tesi di dottorato: II,1,10 (Ai sacerdoti di Costantinopoli e alla città stessa) e II,1,13 (Ai vescovi), rispettivamente di 18 distici elegiaci e 217 esametri. In essi si intrecciano più suggestioni: la meditazione e il riecheggiamento interiore degli eventi che hanno coinvolto l’autore, la difesa del suo operato, ma soprattutto la violenta invettiva contro i vescovi, scaturita non solo dal risentimento per le vicende personali, ma dallo sdegno dell’autore per la corruzione morale e l’impreparazione della gerarchia ecclesiastica. La tesi di dottorato si apre con una bibliografia ricca e aggiornata degli studi concernenti il Cappadoce; in essa sono indicati i diversi contributi, cui si fa riferimento nel mio lavoro. Segue un’ampia introduzione che presenta i carmi sotto molteplici aspetti. Dal momento che l’invettiva contro i vescovi costituisce l’argomento principale di entrambi i
componimenti, ho approfondito innanzitutto questo aspetto, ripercorrendone le testimonianze nell’esperienza biografica e nell’opera letteraria dell’autore: da quanto emerso, la polemica contro la gerarchia ecclesiastica raggiunge certamente il suo apice negli eventi costantinopolitani, ma non va ad essi circoscritta, dal momento che se ne ha traccia anche negli scritti gregoriani riconducibili ai primi anni del sacerdozio e al periodo successivo al ritorno a Nazianzo. Si è cercato poi di stabilire la data di composizione dei carmi in analisi, che, dati i contenuti, furono sicuramente scritti dall’autore nel periodo di ritorno in patria, fase in cui gli studiosi collocano buona parte della produzione poetica del Cappadoce. Più precisamente ho individuato il terminus post quem nel luglio del 381, mese in cui la cattedra costantinopolitana lasciata vacante dal Nazianzeno fu affidata a Nettario: in entrambi i testi, infatti, si fa riferimento a questo personaggio, sebbene non sia menzionato esplicitamente. Segue un’analisi dettagliata della struttura compositiva e delle tematiche dei carmi, nella quale si mostra come, pur nella loro diversità, le due poesie presentino moltissime consonanze e parallelismi a livello strutturale, in particolare nella parte incipitaria, in cui si registra la condivisione dello stesso verso iniziale, e nella sezione conclusiva. Sempre nell’introduzione è affrontato lo studio della tradizione manoscritta e dei rapporti tra i codici: i carmi in oggetto risultano attestati in 34 manoscritti (di cui 17 fondamentali per la costituzione del testo) databili dall’XI al XVI secolo e riconducibili alle raccolte antiche Σ e Δ, nei quali sono traditi sempre uno di seguito all’altro: nello specifico II,1,13 precede immediatamente II,1,10. La parte centrale della tesi è costituita dal testo critico di ciascun carme, seguito da traduzione e commento. La tesi costituisce il primo lavoro di questo tipo per il carme II,1,13; II,1,10 è stato invece oggetto di studio di due recenti edizioni: quella dei primi undici poemata de seipso del Nazianzeno curata da Tuilier - Bady - Bernardi per LesBL ed edita nel 2004 e un’edizione commentata di Simelidis, pubblicata nel 2009. Suddetti lavori non hanno rappresentato un ostacolo al progetto. Nessuno di essi infatti ha previsto lo studio simultaneo dei due testi poetici, che, a mio giudizio, non possono essere compresi a fondo se svincolati l’uno dall’altro; non sono risultati immuni da pecche sotto il profilo della critica testuale; il commento è assente nell’edizione francese, scarno e non sempre condivisibile in quella del Simelidis. La tesi è infine corredata da tre appendici che permettono di seguire la fortuna dei componimenti poetici. La prima di esse è dedicata al Commentario di Cosma di Gerusalemme ai Carmi del Nazianzeno, collocato tra la fine del VII e inizio l’VIII secolo. Il commentario, tradito da un unico manoscritto, il Vaticanus graecus 1260 del XII secolo, ha visto la sua editio princeps nel 1839 a cura del cardinale Angelo Mai nel secondo volume del suo Spicilegium Romanum, ristampata con lievi modifiche nel volume 38 della Patrologia Graeca. Una più recente edizione è stata curata da Lozza nel 2000. Nell’opera di Cosma vengono analizzati trentaquattro versi di carme II,1,13 e due di carme II,1,10; l’ampiezza delle citazioni va da un minimo di un verso a un massimo
di 5. Segue un’appendice dedicata alle parafrasi bizantine, che in alcuni manoscritti contenenti i carmi, accompagnano il testo poetico. Tali spiegazioni in prosa, composte in un momento non precisabile della trasmissione dell’opera gregoriana, sono anonime, di diverso livello letterario e da intendere come un testo in continua evoluzione, oggetto di modifiche da parte di ciascun copista. Nel caso dei testi in oggetto le parafrasi trasmesse sono tre, chiamate, sulla scia di studi precedenti, Paraphr. 1, Paraphr. 2, Paraphr. 3 e delle quali la tesi fornisce l’editio princeps. L’ultima appendice è costituita dalla traduzione latina dei carmi di Giacomo Oliva da Cremona, redatta nella seconda metà del XVI secolo per incarico del Cardinal Guglielmo Sirleto e testimonianza del grande interesse per il Cappadoce in questo periodo storico. Il lavoro dell’Oliva, rimasta inedito per la morte del committente e probabilmente anche per il suo scarso valore letterario, è trasmesso da due manoscritti autografi, il Vaticanus Barberinianus lat. 636 (B) e il Vaticanus lat. 6170 (V) e trova nella tesi la sua editio princeps.
Books on the topic "324.218 3"
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Мазур, О. С. Цивільне право України. Київ: Центр навчальної літератури, 2006.
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United States. Congress. House. Committee on Foreign Affairs. Consideration of miscellaneous bills and resolutions: Full committee markup before the Committee on Foreign Affairs, House of Representatives, One Hundred Third Congress, second session, on H. Res. 323, H. Con. Res. 180, H. Con. Res. 124, H.R. 3813, H.R. 4429, H. Con. Res. 111, H.R. 4635, H.J. Res. 388, H. Res. 476, H. Res. 471, H. Con. Res. 151, H.R. 2826, S.J. Res. 204, proposed legislative language to implement the Uruguay Round, H. Con. Res. 250, H.R. 5030, H.R. 5034, H.R. 4541, H. Con. Res. 257, H.R. 4950, H.R. 5108, H. Con. Res. 286, H. Con. Res. 279, H.R. 5155, H. Con. Res. 302, H. Res. 561, S. Con. Res. 74, H. Con. Res. 216, H. Con. Res. 278, and H. Res. 560, January 25, February 9, March 16, May 18, June 23, July 19, August 3, September 13 and 28, and October 3, 1994. Washington: U.S. G.P.O., 1994.
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3
United States United States Government US Marine Corps. Electronic Warfare - Marine Corps Reference Publication MCRP 3-32D. 1 (Formerly MCWP 3-40. 5) 4 April 2018. Independently Published, 2022.
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United States United States Government US Marine Corps. Electronic Warfare - Marine Corps Reference Publication MCRP 3-32D. 1 (Formerly MCWP 3-40. 5) 4 April 2018. Independently Published, 2022.
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Kosiński, Eryk, ed. Prawo energetyczne Ukrainy. Wybór źródeł/ Енергетичне законодавство України. Вибір джерел/ Energy Law of Ukraine. Selection of sources. Adam Mickiewicz University Press, 2018. http://dx.doi.org/10.14746/amup.9788323237273.
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Publikacja zawiera tłumaczenia na język polski oraz język angielski trzech podstawowych ukraińskich aktów prawnych regulujących sektor energetyczny: 1) ustawy Ukrainy nr 2019-VIII z dnia 13 kwietnia 2017 r. o rynku energii elektrycznej, 2) ustawy Ukrainy nr 329-VIII z dnia 9 kwietnia 2015 r. o rynku gazu ziemnego, oraz 3) ustawy Ukrainy nr 1540-VIII z dnia 22 września 2016 r. o Komisji Narodowej ds. Regulacji Państwowej w Zakresie Energetyki i Usług Komunalnych. Wskazane akty prawne poprzedza wybór przepisów Konstytucji Ukrainy (dokonany przez redaktora pracy), określających „konstytucję gospodarczą” Ukrainy, tj. te przepisy Konstytucji, które odnoszą się do ustroju gospodarczego państwa. Niniejsze opracowanie stanowi pierwszą z dwóch publikacji zaplanowanych w ramach projektu badawczego Narodowego Centrum Nauki nr 2016/21/B/HS5/00054, umowa nr UMO-2016/21/B/HS5/00054, pt. „Regulacja sektora energetycznego w Unii Europejskiej oraz na Ukrainie. Porównanie celów i prawnych środków regulacji sektora energetycznego”. Więcej informacji o projekcie na stronie NCN: https://projekty.ncn.gov.pl/opisy/332425-pl.pdf
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Moloney, Kim. Who Matters at the World Bank? Oxford University PressOxford, 2022. http://dx.doi.org/10.1093/oso/9780192857729.001.0001.
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Abstract This book answers the question, “who matters?” in a 32-year history (1980–2012) of policy change within the World Bank’s public sector management and public sector governance agenda. The book is anchored within the public administration discipline and its understanding of bureaucracy, bureaucratic politics, and stakeholder influences. In response to constructivist scholars’ concerns about politics and the organizational culture of international civil servants within international organizations, this book uses stakeholder theory and a bureaucratic politics approach to suggest the normality of politics, policy debate, and policy evolution. The book also highlights the fact that for 21 of the 32 years, it was the international civil servants of the World Bank and not external stakeholders who led, developed, and institutionalized this sector’s agenda. In doing so, the book explains how one sector of the Bank’s work rose, against the odds, from encompassing just under 3 percent of approved projects in 1980 to its inclusion within 73 per cent of all projects approved between 1991 and 2012.
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Mapping dietary salt/sodium reduction policies and initiatives in the Region of the Americas. Pan American Health Organization, 2021. http://dx.doi.org/10.37774/9789275123232.
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The aim of this study was to map existing country policies and initiatives addressing population dietary sodium reduction in the Region of the Americas; to identify policy gaps following what is outlined in the World Health Organization (WHO) “Best Buys” most cost-effective recommendations for the prevention and control of diet-related noncommunicable diseases (NCDs); and to discuss priorities for future work to reduce population salt/sodium intake. We analyzed data from 34 countries in the Region. A review of different databases informed the mapping. Databases included (1) responses from the online Survey on National Initiatives for Salt/Sodium Reduction in the Americas carried out by PAHO in 2016; (2) the databases from the 2017 and 2019 PAHO Country Capacity Surveys for NCDs and Risk Factors; and (3) the repositories of legislation of the PAHO REGULA initiative as of 2018. Research in these databases was complemented by electronic searches on official websites from the ministries of health, education, and agriculture and the library of the national congress in each country. Additionally, when available, government regulatory gazettes were reviewed. National policies that have adopted the most cost-effective interventions for preventing and controlling diet-related NCDs of WHO “Best Buys” included reformulating food products with both voluntary (n=11/34) and mandatory (n=2/34) targets; establishing a supportive environment in public institutions (n=13/34); consumer awareness programs (n=26/34) and behavior-change communication and mass media campaigns (n=(0/34); and implementing front-of-pack labeling (n=5/34). We also found that some countries have implemented regulations that restrict marketing of foods high in salt/sodium to children (n=5/34), or are using nutritional labeling that includes sodium content, either voluntary (n=9/34) or mandatory (n=10/34). However, no country in the Region has implemented taxes on high salt/sodium foods. Based on our review, we concluded that there has been a significant advance in policies to reduce sodium intake in the Region of the Americas in recent years. However, we identified that the level of implementation is quite varied and is challenging to assess. Despite the progress, there remains much work to do on this issue, especially in countries where there is limited or no action yet. Reducing sodium consumption is a cost-effective intervention that can save many lives by preventing and reducing the burden of diet-related NCDs. Therefore, a further call to action is needed for governments to accelerate efforts to meet the 2025 global target of a 30% relative reduction in mean population intake of sodium.
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Berman, Joshua A. Blending Discordant Laws in Biblical Narrative. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780190658809.003.0009.
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This chapter highlights a peculiar phenomenon in biblical literature outside of the Pentateuch: a biblical writer will invoke iterations of a given law from two or more of the Pentateuch’s four corpora. Scholars have assumed that this phenomenon was limited to post-exilic literature, and stemmed from the exigencies of exile and return that created an urgent need to create a vehicle that would grant legitimacy to various communities and their legal traditions. However, the broad array of books in which such legal blending is found mandates us to question whether the legal blend is strictly a literary phenomenon of the post-exilic period. Moreover, the phenomenon obliges us to question the long-standing assumption that diverging iterations of the same law in two (or more) of the Torah’s law corpora are inherently mutually exclusive. Sources: Josh 20:1–9; Judg 6:25–31; 1 Sam 15:2, 1 Sam 28:3–25; 2 Kgs 4:1–7; Jer 34:12–17; Neh 5:1–12.
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Holzborn, Timo, Holger Alfes, Anne d`Arcy, Marcus Assion, Christiane Breuer, Philipp Dietz, Jörn Ebermann, et al. WpPG. Erich Schmidt Verlag GmbH & Co. KG, 2014. http://dx.doi.org/10.37307/b.978-3-503-15606-1.
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Zentraler Gegenstand dieses Kommentars ist das Wertpapierprospektgesetz (WpPG). Dieses wird durch die EU-Prospektverordnung (809/2004/EG), die im Hinblick auf Gliederung und Mindestinhaltvorgaben des Prospekts direkt anwendbares europäisches Recht darstellt, ergänzt. Die Kommentierung der maßgeblichen Anhänge dieser Verordnung ist hinter § 7 WpPG, welcher den Mindestinhalt festlegt, implementiert. Die entsprechenden Hauptzulassungsnormen in den §§ 32 ff. BörsG und §§ 1 bis 12 BörsZulV sowie die Prospekthaftung in den §§ 21 ff. WpPG werden ebenfalls kommentiert. Die Darstellung des Schweizer Wertpapierprospektrechts gewährt einen wichtigen Einblick und bietet einen hilfreichen Vergleichsmaßstab.
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Innovación Docente y Calidad Institucional : Jornadas de Innovación Docente e Investigación Educativa UZ, Zaragoza, 5 y 6 de septiembre de 2019. Universidad de Zaragoza, 2021. http://dx.doi.org/10.26754/uz.978-84-09-29715-3.
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Índice de Contenidos Aplicación de metodologías activas I 9 Estrategias de gamificación, y aprendizaje entre pares, para la adquisición de competencias 13 Herramientas para la gestión de los recursos digitales en los procesos de enseñanza-aprendizaje 28 Gamificación de la Cristalografía mediante la App XtereO 40 Educación Visual y Plástica comprometida con el entorno próximo 49 Experiencias de coordinación entre el profesorado 67 Diseño de actividades multidisciplinares de Ciencias de la Naturaleza y Matemáticas 71 Evaluación del aprendizaje 99 Impacto del Concurso de Cristalización en la Escuela en Aragón en el profesorado participante. 103 ¿Influye el género en la evaluación entre iguales? 113 Acciones de integración y orientación de estudiantes 133 Competencias digitales para estudiantes de la Universidad de Zaragoza 158 La organización emocional del aula en la gestión de la actividad docente 164 La motivación como herramienta para mejorar la tasa de aprobados en la asignatura de Contabilidad Financiera II. 20 Gamificación a través de diferentes aplicaciones como innovación docente en el grado de Ciencias de la Actividad Física y del Deporte 33 Utilización de vídeos y cuestionarios para la mejora del proceso de enseñanza-aprendizaje de conocimientos requeridos en la asignatura “Criterios de diseño de máquinas” 58 Acercando a los estudiantes de magisterio una experiencia colaborativa realizada en Educación Primaria 78 La formación de los futuros maestros desde un modelo interdisciplinar para las enseñanzas de Lengua Castellana y LIJ. 88 Evaluación de necesidades y seguimiento del aprendizaje en competencias de comunicación académica en inglés a través de un focus group en ADEi 121 Percepción de los estudiantes de los grados de la Facultad de Economía y Empresa sobre el uso y utilidad de las tutorías 137 Integración de los estudiantes de ADE en el mercado laboral a través del programa de prácticas y actividades externas. 148 Promoviendo la reflexión entre docentes acerca delas bases fundamentales sobre las que construirla ciudadanía digital 171 Estudio de opinión de los alumnos del Grado en Medicina sobre las limitaciones éticas de la ciencia 179 Percepción social de la ciencia por los alumnos del Grado en Medicina 185 La dirección de Trabajos Fin de Grado (TFG) en el marco de las nuevas modalidades de educación universitaria a distancia: algunas claves metodológicas para su adecuada ejecución 191 Experiencia piloto para mejorar las competencias de trabajo en equipo y comunicación oral en asignaturas de ingeniería 198 Otras metodologías activas II. 207 Metodologías activas basadas en juegos de razonamiento para fomentar el aprendizaje 211 El dispositivo móvil en el aula, ¿herramienta educativa o distracción? 217 Mejora de la adquisición de competencias a través del modelo de aula inversa 224 El customer journey map en la formación de la empatía y la innovación 232 La gamificación en el aula para la mejora de la participación del alumno en el estudio de la asignatura de Esplacnología. 239 Los cuestionarios Moodle como una herramienta para mejorar la calidad de la docencia y fomentar el aprendizaje en el aula universitaria 246 Un canal de YouTube como mecanismo de adquisición de competencias transversales 251 Arte y reciclaje en los entornos educativos (Trash art) 260 Didáctica con la gamificación y el videojuego mediante una intervención multidisciplinar para estudiantes del Grado de Maestro 270 YouTube como repositorio de vídeos docentes de apoyo a la docencia 278 Aplicación de Metodologías Activas III 287 Combinación de la Técnica Just in Time Teaching y los Serious Games con el enfoque pedagógico Flipped Learning en Educación Superior 291 Aprendizaje de lenguas para la inclusión social 303 Gamificación y role playing en la enseñanza de Derecho Procesal Penal, intervención de la Persona Jurídica y cumplimiento normativo 310 Integrando diferentes aplicaciones TIC en la docencia universitaria: uso de Screencast-o-matic, Canva y Pocket 317 Evaluación del uso de diferentes TIC en la docencia universitaria: grupo MultiFlipTech 323 Experiencias de mejora de la calidad de las titulaciones 335 Coordinación de agentes y mejora de los instrumentos de evaluación de las prácticas escolares: selección de las dimensiones a calificar 339 Enseñanza a distancia en el grado en Gestión y Administración Pública 345 Selección y rendimiento de los estudiantes en la asignatura Organización y Gestión Interna 356
Book chapters on the topic "324.218 3"
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Poland, Therese M., Toral Patel-Weynand, Deborah M. Finch, Chelcy Ford Miniat, Deborah C. Hayes, and Vanessa M. Lopez. "Correction to: Invasive Species in Forests and Rangelands of the United States." In Invasive Species in Forests and Rangelands of the United States, C1. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-45367-1_17.
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The original version of this book was revised as the editor has provided belated corrections for Page xiv, Page 2, Page 19, Page 32, Page 141, Page 159, Page 191, Page 192, Page 194, Page 213, Page 325, Page 343, Page 366, Page 368, and Page 423.
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Gerstendörfer, Monika, and Robert Jütte. "Der § 218 — Das Bundesverfassungsgericht und seine Geschlechterpolitik." In Friedens- und Konfliktforschung, 351–81. Wiesbaden: VS Verlag für Sozialwissenschaften, 1996. http://dx.doi.org/10.1007/978-3-322-97349-8_9.
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Maltry, Karola, and Renate Rausch. "Der Konflikt um den § 218: Ein ungelöster Geschlechterkonflikt." In Friedens- und Konfliktforschung, 329–52. Wiesbaden: VS Verlag für Sozialwissenschaften, 1999. http://dx.doi.org/10.1007/978-3-322-95171-7_13.
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Herwig, Hedda. "Das Urteil des Bundesverfassungsgerichts zu § 218 als Ausdruck herrschender Sexualmoral." In Sexualmoral und Zeitgeist im 19. und 20. Jahrhundert, 147–64. Wiesbaden: VS Verlag für Sozialwissenschaften, 1990. http://dx.doi.org/10.1007/978-3-322-97227-9_8.
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Haribabu, Sangathoti, Muralimohan Cheepu, Venkateswarlu Devuri, and Venkata Charan Kantumuchu. "Optimization of Welding Parameters for Friction Welding of 304 Stainless Steel to D3Tool Steel Using Response Surface Methodology." In Techno-Societal 2018, 427–37. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-16962-6_44.
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Führich, Ernst. "Pauschalreise-Richtlinie 90/314/EWG: Notwendige Änderungen aus deutscher Sicht." In Reiserecht, 19–33. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-09459-4_2.
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Marino, Andrea, Marco Pesce, and Raffaella Succi. "Access to emergency care services and inequalities in living standards: Some evidence from two Italian northern regions." In Proceedings e report, 135–40. Florence: Firenze University Press and Genova University Press, 2023. http://dx.doi.org/10.36253/979-12-215-0106-3.24.
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Rapid access to emergency medical care is crucial in reducing the implications of negative health events in terms of both mortality and disability. Thus, in a well-designed health system the geographical distribution of emergency care services should be able to minimize the share of people whose access time lies beyond critical thresholds. In spite of this, statistical information measuring accessibility to emergency care services at a highly disaggregated level is unavailable in Italy. This paper makes a step in filling this gap, by providing geographically detailed estimates of accessibility in two northern regions, Liguria and Lombardia. To do so, we use three data sources: 1) georeferenced population data measured at the currently most possible detailed level (census enumeration areas, CEAs) from the 2011 Population Census; 2) open data on location of emergency care services; 3) crowdsourced data on road travel distances. Elaborating these data with an efficient algorithm based on open source routing machine provides us with a clear mapping of particularly disadvantaged areas. We find that in 2013 the population share whose access time to emergency care services lies beyond a critical –and policy relevant- threshold of 60 minutes is fairly limited (about 0.1% in both regions). Regional differences emerge when setting lower thresholds. We briefly discuss how accessibility may have evolved in recent years, based upon some conjecture on population dynamics at the CEA level and updated information on emergency care centers. Finally, we analyze how differences in accessibility are related to a set of characteristics describing the population’s living conditions. Different results emerge. In particular, older and less educated people in Liguria face significantly lower access to emergency care. Overall, our results suggest that spatial differences in accessibility -within and between regions- should be considered a relevant determinant of health inequality.
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Hubmer, G., M. Rauchenwald, P. Vilits, and G. Suppan. "304 Hydronephrosen: Indikation, Operationstechnik und Ergebnisse über einen Zeitraum von 24 Jahren." In 40. Tagung, 28. September–1. Oktober 1988, Saarbrücken, 22–23. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-83800-2_7.
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Guelachvili, Guy, and Nathalie Picqué. "16O3 Coriolis and Anharmonic Coupling Parameters of the (114), (213), Dark (080) and (321) Interacting States." In Molecular Constants Mostly from Infrared Spectroscopy, 157. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-57960-2_82.
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Guelachvili, Guy, and Nathalie Picqué. "18O3 Resonance Coupling Parameters of the (025), (430), (501), (214), (115), and the Dark (322) Interacting States." In Molecular Constants Mostly from Infrared Spectroscopy, 558. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-57960-2_350.
Full textConference papers on the topic "324.218 3"
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Kuner, R., M. Laible, S. Gangi-Maurici, C. Walter, C. Bender, G. Schaefer, H. Klocker, M. Oed, V. Bukur, and U. Sahin. "PO-324 Detection of high-risk prostate cancer biomarkers by RNA sequencing and qPCR method." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.354.
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Коробов, Д. С., and А. В. Борисов. "Изучение ресурсной зоны укрепления Подкумское 3 в окрестностях Кисловодска." In Археологические открытия 2018 год. Crossref, 2020. http://dx.doi.org/10.25681/iaras.2020.978-5-94375-326-8.318-321.
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Alfarano, G., C. Balestrieri, M. Audano, M. Milan, G. Diaferia, N. Mitro, and G. Natoli. "PO-324 Interferon regulatory factor 1 (IRF1) regulates inflammatory and metabolic phenotypes in pancreatic ductal adenocarcinoma." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.837.
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Grumolato, L., A. Guernet, D. Alexandre, L. Brunet, MDM Blanquer Rosselló, R. Sachidanandam, S. Aaronson, and Y. Anouar. "Po-327 Modelling intratumor heterogeneity through CRISPR-barcodes." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.840.
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Simon, T., S. Mamlouk, S. Khouja, M. Andrea, L. Dido, K. Detjen, M. Pavel, F. Rossner, J. Haybäck, and C. Sers. "PO-329 Genomic aberration in pancreatic neuroendocrine tumours (PNET)." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.359.
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Astley, R., G. Cheng, A. Droop, E. Black, M. Knowles, and C. Hurst. "PO-323 Tumour evolution in non-muscle-invasive bladder cancer." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.353.
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Tarabichi, M., I. Martincorena, M. Gerstung, F. Markowetz, P. Spellman, Q. Morris, OC Lingjærde, D. Wedge, P. Van Loo, and WG Pcawg. "PO-329 Rejecting neutral tumour evolution across human cancer types." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.842.
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Thangavelu, PU, LE Reid, M. Lim, M. Molaei, AE McCart Reed, JM Saunus, E. Dray, PT Simpson, SR Lakhani, and PHG Duijf. "PO-321 Causes and consequences of WDHD1 overexpression in breast cancer." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.351.
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Marzouka, NAD, P. Eriksson, D. Lindgren, F. Liedberg, C. Bernardo, G. Sjödahl, H. Axelson, and M. Höglund. "PO-326 Genetic stability of multiple recurrences in bladder cancer patients." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.839.
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Berg, KCG, A. Sveen, M. Høland, M. Berg, M. Hektoen, S. Alagaratnam, A. Nesbakken, K. Søreide, and RA Lothe. "PO-325 Novel recurrent high-level amplifications in microsatellite stable colorectal cancer." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.355.
Full textReports on the topic "324.218 3"
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Dorman, Eleanor, Zara Markovic-Obiago, Julie Phillips, Richard Szydlo, and Darren K. Patten. Wellbeing in UK Frontline Healthcare Workers During Peaks One and Three of the COVID-19 Pandemic: A Retrospective Cross-Sectional Analysis. Science Repository, December 2022. http://dx.doi.org/10.31487/j.ejgm.2022.01.01.
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Background: COVID-19 had a huge impact on the wellbeing of healthcare workers (HCWs). This is well documented during the first peak of the pandemic. With cases in the UK rising for a third peak, hospitalisations and deaths surpassing the first, there is very little known about the mental health of HCWs during this time. Methods: Using a questionnaire, data was collected from patient-facing staff at Barking, Havering, and Redbridge University Trust to quantify and compare the period prevalence of symptoms of depression, anxiety, and PTSD during the first peak (P1: March-May 2020) and third peak (P3: December 2020-Feburary 2021) of the COVID-19 pandemic as well as wellbeing service use, demographics of responders and what they found most difficult during the peaks. Results: Of 158 responders, only 22·4% felt they had enough access to wellbeing services during P1 and 21·5% in P3. Of those who used wellbeing services 34·4% found them useful in P1 and 34·6% in P3. 70·3% of responders felt that not enough was done for staff wellbeing. The median anxiety score decreased from P1 (10(range 5-17)) to P3 (8(range 4-16)) p=0·031. Under 30-year-olds’ depression and PTSD scores increased from P1 to P3 (depression: P1 7(1-11), P3 8(3-14), p=0·048, PTSD: P1 4(0-7) peak 3 5(2-9), p=0·037). Several groups showed a decrease in anxiety scores from P1 to P3 including; over 30-year-olds (P1 10(5-17), P3 7(3-15) p=0·002), BME responders (P1 8(3·75-15) P3 6·5(1-12) p=0·006), AHP (P1 14(7-19), P3 11(5-19) p=0·005), ITU workers (P1 15(8-18·25) P3 12(5·75-18·25) p=0·004), and those who were redeployed (P1 8(5-18·25), P3 5(2-14·75), p=0·032). Conclusion: We have observed changes in mental health symptoms within the study population as the peaks of the pandemic continue. With the majority of responders reporting they felt not enough had been done for their wellbeing support - and of those who used the wellbeing services only around 1/3 felt they were useful - we hope that this paper can help inform wellbeing provision and identify groups at higher risk of developing mental health symptoms.
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Erdman, Richard, Geoffrey Dahl, Hanina Barash, Israel Bruckental, Avi Shamay, and Anthony Capuco. Management Strategies to Maximize Skeletal Growth Rate in Dairy Heifers. United States Department of Agriculture, July 2002. http://dx.doi.org/10.32747/2002.7695848.bard.
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The objectives of this study were to determine the effects of recombinant bovine somatotropin (bST) and added dietary rumen undegradable protein (RUP) on organ and tissue weights and body composition in growing dairy heifers. A total of 32 Holstein heifers, 3 months of age at the beginning of the study were used in the experiment. Eight heifers were slaughtered at 3 mo of age to determine pre- treatment body composition. The remaining heifers were randomly assigned to treatments (n=6) consisting of 0.1 mg/kg body weight per day of bST and 2% added dietary RUP (dry matter basis) applied in a 2X2 factorial design. A total of six heifers per treatment group (3 each at 5 and 10 mo of age), were slaughtered to determine body composition an organ masses. There was a trend for increased live and empty body weights (EB:W), carcass and non-carcass components for heifers treated with bST or fed RUP. Added RUP increased rumen and reticulum weights whereas administration of bST tended to increase the weights of small and large intestine at 10 months of age by 22 % and 26%, respectively. Spleen, heart, and kidney weights at 10 months of age were increased 36%, 28% and 23% for bST treatments respectively, compared with controls. Rates of ash and protein deposition between 3 and 10 months of age were increased by bST by 7.2 g/d and 28.9 g/d, respectively, while no treatment differences were observed for rates of fat and energy deposition. Bovine somatotropin significantly altered the metabolism of growing heifers in a manner that led to increased protein and ash deposition, and tended to reduce fat percentage, and there was a similar tendency observed with added RUP. This suggests that nutritional and endocrine manipulations could increase growth rates of skeletal and lean tissues without increasing fat deposition in prepubertal dairy heifers.
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Lucas, Brian. Lessons Learned about Political Inclusion of Refugees. Institute of Development Studies, May 2022. http://dx.doi.org/10.19088/k4d.2022.114.
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Most refugees and other migrants have limited opportunities to participate in politics to inform and influence the policies that affect them daily; they have limited voting rights and generally lack effective alternative forms of representation such as consultative bodies (Solano & Huddleston, 2020a, p. 33). Political participation is ‘absent (or almost absent) from integration strategies’ in Eastern European countries, while refugees and other migrants in Western Europe do enjoy significant local voting rights, stronger consultative bodies, more funding for immigrant organisations and greater support from mainstream organisations (Solano & Huddleston, 2020a, p. 33).This rapid review seeks to find out what lessons have been learned about political inclusion of refugees, particularly in European countries.In general, there appears to be limited evidence about the effectiveness of attempts to support the political participation of migrants/refugees. ‘The engagement of refugees and asylum-seekers in the political activities of their host countries is highly understudied’ (Jacobi, 2021, p. 3) and ‘the effects that integration policies have on immigrants’ representation remains an under-explored field’ (Petrarca, 2015, p. 9). The evidence that is available often comes from sources that cover the entire population or ethnic minorities without specifically targeting refugees or migrants, are biased towards samples of immigrants who are long-established in the host country and may not be representative of immigrant populations, or focus only on voting behaviour and neglect other forms of political participation (Bilodeau, 2016, pp. 30–31). Statistical data on refugees and integration policy areas and indicators is often weak or absent (Hopkins, 2013, pp. 9, 28–32, 60). Data may not distinguish clearly among refugees and other types of migrants by immigration status, origin country, or length of stay in the host country; may not allow correlating data collected during different time periods with policies in place during those periods and preceding periods; and may fail to collect a range of relevant migrant-specific social and demographic characteristics (Bilgili et al., 2015, pp. 22–23; Hopkins, 2013, p. 28).
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Reifenberg, Dirk, and Veronika Phillips. Internationale Studierendenmobilität in Deutschland: Ergebnisbericht zum ersten Benchmark internationale Hochschule (BintHo) im Wintersemester 2020/21. Deutscher Akademischer Austauschdienst (DAAD), April 2023. http://dx.doi.org/10.46685/daadstudien.2023.05.
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An der ersten Befragung im Rahmen des BintHo-Projekts im Wintersemester 2020/21 nahmen insgesamt über 117.000 Studierende teil, darunter auch rund 14.000 internationale Studierende. Die Befragten stammten von insgesamt 74 teilnehmenden Universitäten (33), Hochschulen für angewandte Wissenschaften (34), Pädagogischen Hochschulen (4) sowie Kunst- und Musikhochschulen (3) in 14 Bundesländern mit Studierendenzahlen zwischen knapp 400 und über 50.000 Studierenden. Die erste BintHo-Befragungsrunde verfügt damit über eine beeindruckende Datengrundlage. Aufgrund der hohen Anzahl und des breit gefächerten Spektrums teilnehmender Hochschulen und befragter Studierender liefern diese Befunde eine aussagekräftige Beschreibung des Stands der internationalen Studierendenmobilität in Deutschland zu Beginn der 2020er Jahre. In Zukunft sollen die BintHo-Befragungen alle drei Jahre wiederholt werden. Die erste BintHo-Befragung liefert spannende und größtenteils erfreuliche Befunde: So zeigt sich beispielsweise, dass für mehr als drei Viertel der befragten internationalen Studierenden Deutschland die erste Wahl als Gastland war. Die wichtigsten Gründe für das Studium in der Bundesrepublik waren dabei ein attraktives Studienangebot und gute Studienbedingungen an den Hochschulen, das internationale Renommee des deutschen Studienabschlusses sowie gute berufliche Perspektiven nach dem Studium. Zugleich wünschten sich rund 40 Prozent der einheimischen Studierenden mehr internationale Kommilitonen und Kommilitoninnen, nur ein Prozent hätte gerne weniger internationale Studierende an der eigenen Hochschule. Betrachtet man die Befunde zur Auslandsmobilität der einheimischen Studierenden, so zeigt sich: Die wichtigsten Motive für einen Auslandsaufenthalt sind die Persönlichkeitsentwicklung, kulturelles Interesse und der Wunsch, neue Erfahrungen im Gastland außerhalb der Universität zu machen. Die BintHo-Studie belegt auch einen Zusammenhang zwischen dem Verhalten von Lehrenden und der Auslandsmobilität ihrer Studierenden: Unter den Studierenden die angaben, dass sie nie von Lehrenden zu einem Auslandsaufenthalt ermutigt wurden, fällt der Anteil der auslandsmobilen Studierenden am niedrigsten aus. Besonders hoch fällt dieser Anteil hingegen in der Gruppe der Befragten aus, die erklärten, alle Lehrenden ermutigten sie zu einem Auslandsaufenthalt.
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Pavlovic, Noel, Barbara Plampin, Gayle Tonkovich, and David Hamilla. Special flora and vegetation of Indiana Dunes National Park. National Park Service, 2024. http://dx.doi.org/10.36967/2302417.
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The Indiana Dunes (comprised of 15 geographic units (see Figure 1) which include Indiana Dunes National Park, Dunes State Park, and adjacent Shirley Heinze Land Trust properties) are remarkable in the Midwest and Great Lakes region for the vascular plant diversity, with an astounding 1,212 native plant species in an area of approximately 16,000 acres! This high plant diversity is the result of the interactions among postglacial migrations, the variety of soil substrates, moisture conditions, topography, successional gradients, ?re regimes, proximity to Lake Michigan, and light levels. This richness is all the more signi?cant given the past human alterations of the landscape resulting from logging; conversion to agriculture; construction of transportation corridors, industrial sites, and residential communities; ?re suppression; land abandonment; and exotic species invasions. Despite these impacts, multiple natural areas supporting native vegetation persist. Thus, each of the 15 units of the Indiana Dunes presents up to eight subunits varying in human disturbance and consequently in ?oristic richness. Of the most signi?cant units of the park in terms of number of native species, Cowles Dunes and the Dunes State Park stand out from all the other units, with 786 and 686 native species, respectively. The next highest ranked units for numbers of native species include Keiser (630), Furnessville (574), Miller Woods (551), and Hoosier Prairie (542). The unit with lowest plant richness is Heron Rookery (220), with increasing richness in progression from Calumet Prairie (320), Hobart Prairie Grove (368), to Pinhook Bog (380). Signi?cant natural areas, retaining native vegetation composition and structure, include Cowles Bog (Cowles Dunes Unit), Howes Prairie (Cowles Dunes), Dunes Nature Preserve (Dunes State Park), Dunes Prairie Nature Preserve (Dunes State Park), Pinhook Bog, Furnessville Woods (Furnessville), Miller Woods, Inland Marsh, and Mnoke Prairie (Bailly). Wilhelm (1990) recorded a total of 1,131 native plant species for the ?ora of the Indiana Dunes. This was similar to the 1,132 species recorded by the National Park Service (2014) for the Indiana Dunes. Based on the nomenclature of Swink and Wilhelm (1994), Indiana Dunes National Park has 1,206 native plant species. If we include native varieties and hybrids, the total increases to 1,244 taxa. Based on the nomenclature used for this report?the Flora of North America (FNA 2022), and the Integrated Taxonomic Information System (ITIS 2022)?Indiana Dunes National Park houses 1,206 native vascular plant species. As of this writing (2020), the Indiana Dunes is home to 37% of the species of conservation concern in Indiana (241 out of 624 Indiana-listed species): state extirpated = 10 species, state endangered = 75, and state threatened = 100. Thus, 4% of the state-listed species in the Indiana Dunes are extirpated, 31% endangered, and 41% threatened. Watch list and rare categories have been eliminated. Twenty-nine species once documented from the Indiana Dunes may be extirpated because they have not been seen since 2001. Eleven have not been seen since 1930 and 15 since 1978. If we exclude these species, then there would be a total of 1,183 species native to the Indiana Dunes. Many of these are cryptic in their life history or diminutive, and thus are di?cult to ?nd. Looking at the growth form of native plants, <1% (nine species) are clubmosses, 3% (37) are ferns, 8% (297) are grasses and sedges, 56% (682) are forbs or herbs, 1% (16) are herbaceous vines, <1% (7) are subshrubs (woody plants of herbaceous stature), 5% (60) are shrubs, 1% (11) are lianas (woody vines), and 8% (93) are trees. Of the 332 exotic species (species introduced from outside North America), 65% (219 species) are forbs such as garlic mustard (Alliaria petiolata), 15% (50 species) are graminoids such as phragmites (Phragmites australis ssp. australis), 2% (seven species) are vines such as ?eld bindweed (Convulvulus arvensis), <1% (two species) are subshrubs such as Japanese pachysandra (Pachysandra terminalis), 8% (28 species) are shrubs such as Asian bush honeysuckle (Lonicera spp.), 1% (three species) are lianas such as oriental bittersweet (Celastrus orbiculatus), and 8% (23 species) are trees such as tree of heaven (Ailanthus altissimus). Of the 85 adventive species, native species that have invaded from elsewhere in North America, 14% (11 species) are graminoids such as broom sedge (Andropogon virginicus), 57% (48 species) are forbs such as fall phlox (Phlox paniculata), 5% (six species) are shrubs such as Carolina allspice (Calycanthus floridus), 3% (two species) are subshrubs such as holly leaved barberry (Berberis repens), 1% (one species) is a liana (trumpet creeper (Campsis radicans), 3% two species) are herbaceous vines such as tall morning glory (Ipomoea purpurea), and 17% (15 species) are trees such as American holly (Ilex opaca). A total of 436 species were found to be ?special? based on political rankings (federal and state-listed threatened and endangered species), species with charismatic ?owers, and those that are locally rare.
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Larramendy, Peter, Linnea Hall, and Annie Little. Landbird trends 2016–2021, and 2021 annual report: Channel Islands National Park. National Park Service, August 2023. http://dx.doi.org/10.36967/2299629.
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The National Park Service (NPS) began monitoring landbirds at Channel Islands National Park in 1993 as part of its long-term inventory and monitoring program. The park’s landbird monitoring later became part of the NPS Inventory and Monitoring Division’s Mediterranean Coast Network long-term monitoring programs. Consequently, landbird monitoring has been conducted during every breeding season since 1993. In this report, we summarize data collected during the 2021 breeding season and we analyze trends in a select number of species. Landbird monitoring was conducted between 10 March and 22 May 2021. Using distance-based sampling methods in a standardized protocol, birds were counted on 334 of 338 permanent point count stations (99%) across the Channel Islands monitored for landbirds. These surveys were conducted at 29 of 33 points on Santa Barbara Island, 8 of 8 on East Anacapa Islet, 112 of 112 on Santa Cruz Island, 40 of 40 on San Miguel Island, and 145 of 145 on Santa Rosa Island. Four points on Santa Barbara Island were not counted due to nesting California Brown Pelicans (Pelecanus occidentalis) and Western Gulls (Larus occidentalis); 3 of 4 points (i.e., 17, 19, and 20) were also not counted in 2016–2021 to avoid disturbing breeding pelicans. This was the first monitoring season that the permanent line transects on Santa Barbara, East Anacapa, and San Miguel Islands were not surveyed. During the 2021 monitoring season, Channel Islands National Park decided to stop using line transects and focus on point count stations only, based on an external review of the landbird monitoring program. Fifty-six bird species were counted at point count stations across all of the islands in 2021. Parkwide, 40 of these species are breeders in Channel Islands National Park. Parkwide, the 10 most detected breeding landbirds in 2021 were, in descending order: Spotted Towhee, Song Sparrow, Bewick’s Wren, Orange-crowned Warbler, House Finch, Western Meadowlark, Horned Lark, Common Raven, Island Scrub-Jay, and Pacific-slope Flycatcher (scientific names in Table 2 and Appendix A). On East Anacapa Islet, 26 landbird species have been counted since 1993; 7 species were counted in 2021. No new transient species were detected in 2021; 6 transient or visiting species have been counted on the island overall since 1993. On Santa Barbara Island, 50 landbird species have been counted since 1993; 13 species were counted in 2021. Lincoln’s Sparrow was a new transient species counted in 2021 on Santa Barbara; 23 transient or visiting species have been counted on the island since 1993. On Santa Cruz Island, 78 landbird species have been counted since 2013; 45 species were counted in 2021. Hermit Warbler, Lawrence’s Goldfinch and Warbling Vireo were new transient species counted in 2021 on Santa Cruz Island; 21 transient or visiting species have been counted on this island since 2013. On San Miguel Island, 70 landbird species have been counted since 1993; 10 were counted in 2021. No transient species were counted in 2021; 32 transient or visiting species have been counted on the island since 1993. On Santa Rosa Island, 78 landbird species have been counted since 1994; 39 were detected in 2021. No new transient species were counted in 2021 on Santa Rosa; 21 transient or visiting species have been counted on the island since 1994. Nonnative and invasive birds were counted on only 1 of the 5 islands in 2021: 23 European Starlings on Santa Rosa Island. However, anecdotal sightings of nonnative species occurred more frequently (i.e., outside of survey times) on Santa Cruz and Santa Rosa Islands in 2021. The highest numbers of nonnative species detections occurred on Santa Rosa Island, with 25 detections of Eurasian Collared Dove (primarily at the Historic Ranch), 18 detections of European Starling (Historic Ranch), 2 detections of Brown-headed Cowbird, and 1 Rock Pigeon detection (Historic Ranch). Other species were not reported by Channel Islands National Park landbird monitors or in eBird in 2021. This was the first annual monitoring report since the Coonan and Dye (2016) trend report to incorporate density estimates for particular species across Channel Islands National Park. Parkwide, 13 species were analyzed using the Distance Package in R. Of the 13 species analyzed, 5 had either increasing or decreasing densities from 2016 to 2021. All park islands except for Santa Barbara had a species that showed an increasing or decreasing trend from 2016 to 2021. Horned Lark and House Finch on San Miguel Island were the only species to show decreasing trends from 2016 to 2021, which is opposite from the trend presented by Coonan and Dye (2016).
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Hall, Linnea, Peter Larramendy, Lena Lee, and Annie Little. Landbird monitoring 2020 annual report: Channel Islands National Park. National Park Service, 2023. http://dx.doi.org/10.36967/2301088.
Full textAbstract:
The National Park Service (NPS) began monitoring landbirds at Channel Islands National Park in 1993 as part of its long-term inventory and monitoring program. The park?s landbird monitoring later became part of the NPS Inventory and Monitoring Division?s Mediterranean Coast Network long-term monitoring programs. Consequently, landbird monitoring has been conducted in the park during every breeding season since 1993. In this report, we summarize data collected during the 2020 breeding season. Landbird monitoring was conducted between 1 April and 30 June 2020. Using distance-based sampling methods in a standardized protocol, birds were counted on 7 of 10 permanent line transects (70%) (2 of 3 on Santa Barbara Island, 1 of 1 on East Anacapa Island, and 4 of 5 on San Miguel Island). Two transects were not sampled in 2020 because of nesting California Brown Pelicans (Pelecanus occidentalis) on Santa Barbara Island (i.e., Canyons Transect) and reduced person hours and unfavorable winds on San Miguel Island (i.e., San Miguel Hill Transect). For point counts, 225 of 338 (67%) permanent stations were counted (i.e., 30 of 33 points on Santa Barbara Island, 8 of 8 on East Anacapa Island, 100 of 112 on Santa Cruz Island, 40 of 40 on San Miguel Island, and 47 of 145 on Santa Rosa Island). The 8 Prisoners? Cove points were not counted in 2020. Three points were not counted on Santa Barbara Island due to nesting pelicans: these points and the transect were also not counted in 2016?2019 to avoid disturbing breeding pelicans. Other points (i.e., on east Santa Cruz Island and Santa Rosa Island) were not counted due in large part to the global COVID-19 pandemic. Traveling to and from the park was only granted to essential NPS staff for the majority of the landbird season. Fifty-one bird species were counted from points and transects across all of the islands in 2020; 39 of these are breeding species on the island. Parkwide, the 10 most commonly detected breeding landbirds in 2020 were, in descending order: Horned Lark, Spotted Towhee, Song Sparrow, White-crowned Sparrow, Western Meadowlark, Orange-crowned Warbler, Bewick?s Wren, Island Scrub-Jay, House Finch, and Common Raven. On East Anacapa Island, 26 landbird species have been counted since 1993; 5 species were counted in 2020. No new transient species were detected in 2020; 10 transient or visiting species (nonbreeding, native species recorded only once or twice during surveys) have been counted on the island overall since 1993. On Santa Barbara Island, 49 landbird species have been counted since 1993; 15 species were counted in 2020. The highest number of Horned Lark since 1993 were counted in 2020 (n = 451). Warbling Vireo was a new transient species counted in 2020 on Santa Barbara; 30 transient or visiting species have been counted on the island since 1993. On Santa Cruz Island, 74 landbird species have been counted since 2013; 34 species were counted in 2020. Bullock?s Oriole was a new transient species counted in 2020 on Santa Cruz; 21 transient or visiting species have been counted on this island since 2013. On San Miguel Island, 69 landbird species have been counted since 1993; 14 were counted in 2020. No transient species were counted in 2020; 34 transient or visiting species have been counted on the island since 1993. On Santa Rosa Island, 75 landbird species have been counted since 1994; 26 were detected in 2020. Rose-breasted Grosbeak was a new transient species counted in 2020 on Santa Rosa Island; 30 transient or visiting species have been counted on the island since 1994. Across all the 5 islands, 3 transient or visiting bird species were newly counted in 2020, for a total of 77 such species counted since NPS monitoring began on the islands. Nonnative and invasive birds were counted on only 1 of the 5 islands in 2020: 4 European Starlings on Santa Rosa Island. However, anecdotal sightings of nonnative species occurred much more frequently (i.e., outside of the point and transect counts), and were made on all islands except Anacapa in 2020. The highest numbers of nonnative species detections occurred on Santa Cruz Island, with 33 detections of Eurasian Collared Dove (primarily at the Main Ranch area in the Central Valley), 15 detections of Brown-headed Cowbird (primarily at Scorpion Harbor), and 15 detections of European Starling (primarily at the Main Ranch and Scorpion Harbor). House Sparrows were observed fewer times, but on all islands except Anacapa; cowbirds occurred on all islands except Anacapa and San Miguel; and Rock Pigeon occurred on Santa Barbara and Santa Cruz Islands. In 2020, despite the COVID-19 pandemic, 67% of all points and 77% of all transects were counted among the 5 islands. Santa Rosa received the lightest sampling of points (32%), due to the difficulty of getting observers onto the island. Even with diminished sampling, species richness (number of species) values fell in predictable patterns: richness was greatest on the larger islands (75 on Santa Rosa, 73 on Santa Cruz) and least on the smallest islands (26 on Anacapa, 48 on Santa Barbara). We continue to recommend that nonnative invasive species, such as European Starlings on Santa Rosa Island, be removed before their numbers become harder to manage. Also, because Distance analyses assist statistically with evaluations of trends, we continue to recommend that a trend analysis using program DISTANCE, or newer hierarchical distance analyses, should be used after the 2020 season to assess 5-year trends in breeding species? numbers following the 2015 trend analysis conducted by Coonan and Dye (2016).
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Brown, Yolanda, Twonia Goyer, and Maragaret Harvey. Heart Failure 30-Day Readmission Frequency, Rates, and HF Classification. University of Tennessee Health Science Center, December 2020. http://dx.doi.org/10.21007/con.dnp.2020.0002.
Full textAbstract:
30 Day Hospital Readmission Rates, Frequencies, and Heart Failure Classification for Patients with Heart Failure Background Congestive heart failure (CHF) is the leading cause of mortality, morbidity, and disability worldwide among patients. Both the incidence and the prevalence of heart failure are age dependent and are relatively common in individuals 40 years of age and older. CHF is one of the leading causes of inpatient hospitalization readmission in the United States, with readmission rates remaining above the 20% goal within 30 days. The Center for Medicare and Medicaid Services imposes a 3% reimbursement penalty for excessive readmissions including those who are readmitted within 30 days from prior hospitalization for heart failure. Hospitals risk losing millions of dollars due to poor performance. A reduction in CHF readmission rates not only improves healthcare system expenditures, but also patients’ mortality, morbidity, and quality of life. Purpose The purpose of this DNP project is to determine the 30-day hospital readmission rates, frequencies, and heart failure classification for patients with heart failure. Specific aims include comparing computed annual re-admission rates with national average, determine the number of multiple 30-day re-admissions, provide descriptive data for demographic variables, and correlate age and heart failure classification with the number of multiple re-admissions. Methods A retrospective chart review was used to collect hospital admission and study data. The setting occurred in an urban hospital in Memphis, TN. The study was reviewed by the UTHSC Internal Review Board and deemed exempt. The electronic medical records were queried from July 1, 2019 through December 31, 2019 for heart failure ICD-10 codes beginning with the prefix 150 and a report was generated. Data was cleaned such that each patient admitted had only one heart failure ICD-10 code. The total number of heart failure admissions was computed and compared to national average. Using age ranges 40-80, the number of patients re-admitted withing 30 days was computed and descriptive and inferential statistics were computed using Microsoft Excel and R. Results A total of 3524 patients were admitted for heart failure within the six-month time frame. Of those, 297 were re-admitted within 30 days for heart failure exacerbation (8.39%). An annual estimate was computed (16.86%), well below the national average (21%). Of those re-admitted within 30 days, 50 were re-admitted on multiple occasions sequentially, ranging from 2-8 re-admissions. The median age was 60 and 60% male. Due to the skewed distribution (most re-admitted twice), nonparametric statistics were used for correlation. While graphic display of charts suggested a trend for most multiple re-admissions due to diastolic dysfunction and least number due to systolic heart failure, there was no statistically significant correlation between age and number or multiple re-admissions (Spearman rank, p = 0.6208) or number of multiple re-admissions and heart failure classification (Kruskal Wallis, p =0.2553).
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Söderberg, Linda, Stefan Palm, Caroline Ek, and Johan Östergren. Fem års DNA-analys av avelsfisk - kompensationsodlad lax och havsöring från åtta älvar. Department of Aquatic Resources, Swedish University of Agricultural Sciences, 2023. http://dx.doi.org/10.54612/a.1tnjl9jc1a.
Full textAbstract:
För att kompensera för kraftigt minskad naturlig reproduktion orsakad av vattenkraftsutbyggnad sker odling och utsättning av betydande mängder lax och havsöring i ett flertal av våra större vattendrag. Varje år tas nya avelsfiskar in för kramning (sea ranching). I Sverige ska all kompensationsodlad utsatt fisk vara fettfeneklippt. Tidigare märktes även en andel av lax- och havsöringsungarna (smolten) med yttre så kallade Carlinmärken, där inrapporterade återfynd har använts för olika studier och uppföljningar. Av flera olika anledningar har dock dessa märkningar i princip upphört. Som ett alternativ till yttre märkning har molekylärgenetiska analyser av återvändande avelsfisk börjat användas för att samla in information om de kompensationsodlade lax- och havsöringsstammarna. Genom att dra nytta av det faktum att samtliga individer bär på en unik genuppsättning, går det att baserat på data från återkommande DNA-analyser av avelsfisk göra diverse uppföljningar av odlingsverksamheten. De första DNA-analyserna genomfördes 2014. Därefter har antalet stammar som omfattas av analyserna gradvis ökat. Resultat från DNA-analyser av lax och havsöring erhållna till och med aveln 2018 har presenterats tidigare (Söderberg m.fl. 2019). I denna rapport ges en uppdaterad sammanställning av slutsatser och erfarenheter baserad på fortsatta analyser (t.o.m. aveln 2022) av totalt sju lax- och sex havsöringsstammar. Samtliga de undersökta lax- och havsöringsstammarna uppvisade jämförelsevis hög genetisk variationsgrad, vilket kan förklaras av att det genom åren ingått inslag av älvsfrämmande individer bland de kramade avelsfiskarna. För lax i Skellefteälven observerades dock en signifikant minskad variationsgrad (färre anlagsvarianter) från 2014 till 2022 vilken kan återspegla en relativt hög förekomst av sterila hanar i kombination med att man relativt nyligen övergått till att para en hona med endast en hane. Under samma tidsperiod uppvisade laxen i Ljusnan tecken på ökad genetisk variationsgrad, vilket sammanfaller med en kraftigt ökad andel identifierad älvsfrämmande avelsfisk (från 3-4 % 2014-2015 till drygt 50 % 2022, en extremt hög nivå). Med undantag för Ljusnan varierade den genomsnittliga andelen älvsfrämmande lax mellan 0,3 och 3,3 %. Även för havsöring var andelen älvsfrämmande avelsfisk identifierad via DNA låg och utan något exempel på en större förändring över tid. Hos båda arterna härstammade de flesta älvsfrämmande avelsfiskarna från geografiskt mer närliggande älvar. Hittills (t.o.m. 2022) har ca 25 % av de DNA-analyserade avelslaxarna identifierade föräldrar från tidigare år, där Skellefteälven och Lagan dominerar tack vare längst tidsserier. Inom några år förväntas föräldrar till samtliga odlade individer från de sju laxstammar som ingår i projektet att kunna identifieras. För havsöring, som analyserats under kortare tid, är andelen med identifierade föräldrar hittills endast 8 %. Även för denna art förväntas en snabbt ökande andel avelsfisk med identifierade föräldrar under de kommande åren. Andelen identifierade helsyskon som råkat bli parade med varandra varierade mellan noll och några få procent per år och stam, med tendens till något högre andelar hos havsöring jämfört med lax. Avslutningsvis ges några exempel där DNA-baserade föräldraskapsbestämningar (för lax) använts som utgångspunkt för storleksjämförelser av hanar och honor med olika antal år i havet, ursprungsidentifieringar av kustfångade odlade individer, konstruktion av stamträd (pedigree) samt beräkningar av genetiskt effektiv populationsstorlek (Ne). Baserat på antal återvändande avkommor per kramad förälder beräknades Ne för lax i Skellefteälven och Lagan till omkring 200 respektive 320 (per generation), vilket understiger det långsiktiga mål om Ne ≥ 500 som ofta refereras till i genetiska bevarandesammanhang. För att erhålla ökade effektiva populationsstorlekar krävs sannolikt fler avelslaxar i kombination med åtgärder som syftar till att ge en minskad variation i antalet avkommor per förälder.
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Dudoit, Alain, Molivann Panot, and Thierry Warin. Towards a multi-stakeholder Intermodal Trade-Transportation Data-Sharing and Knowledge Exchange Network. CIRANO, December 2021. http://dx.doi.org/10.54932/mvne7282.
Full textAbstract:
The performance of supply chains used to be mainly the concern of academics and professionals who studied the potential efficiencies and risks associated with this aspect of globalisation. In 2021, major disruptions in this critical sector of our economies are making headlines and attracting the attention of policy makers around the world. Supply chain bottlenecks create shortages, fuel inflation, and undermine economic recovery. This report provides a transversal and multidisciplinary analysis of the challenges and opportunities regarding data interoperability and data sharing as they relate to the ‘Great Lakes - St. Lawrence Seaway Trade Corridor’ (GLSLTC)’s intermodal transportation and trade data strategy. The size and scope of this trade corridor are only matched by the complexity of its multimodal freight transportation systems and growing urbanization on both sides of the Canada-US border. This complexity is exacerbated by the lack of data interoperability and effective collaborations between the different stakeholders within the various jurisdictions and amongst them. Our analytical work relies on : 1) A review of the relevant documentation on the latest challenges to supply chains (SC), intermodal freight transport and international trade, identifying any databases that are to be used.; 2) A comparative review of selected relevant initiatives to give insights into the best practices in digital supply chains implemented in Canada, the United States, and the European Union.; 3) Interviews and discussions with experts from Transport Canada, Statistics Canada, the Canadian Centre on Transportation Data (CCTD) and Global Affairs Canada, as well as with CIRANO’s research community and four partner institutions to identify databases and data that they use in their research related to transportation and trade relevant data availabilities and methodologies as well as joint research opportunities. Its main findings can be summarized as follow: GLSLTC is characterized by its critical scale, complexity, and strategic impact as North America’s most vital trade corridor in the foreseeable further intensification of continental trade. 4% of Canadian GDP is attributed to the Transportation and Logistics sector (2018): $1 trillion of goods moved every year: Goods and services imports are equivalent to 33% of Canada’s GDP and goods and services exports equivalent to 32%. The transportation sector is a key contributor to the achievement of net-zero emissions commitment by 2050. All sectors of the Canadian economy are affected by global supply chain disruptions. Uncertainty and threats extend well beyond the COVID-19 Pandemic. “De-globalization” and increasing supply chains regionalization pressures are mounting. Innovation and thus economic performance—increasingly hinges on the quantity and quality of data. Data is transforming Canada’s economy/society and is now at the center of global trade “Transport data is becoming less available: Canada needs to make data a priority for a national transportation strategy.” * “How the Government of Canada collects, manages, and governs data—and how it accesses and shares data with other governments, sectors, and Canadians—must change.”