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Academic literature on the topic '303.48/3/08'

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Published: 26 July 2024

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Journal articles on the topic "303.48/3/08"

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Wes, A., J. Sun, A. Foglio, K. Magoon, and J. Taylor. "S3-08 SESSION 3." Plastic and Reconstructive Surgery - Global Open 7 (August 2019): 34–35. http://dx.doi.org/10.1097/01.gox.0000582920.12029.eb.

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Dubb, A. "3-22-08 Forerunners of neurology." Journal of the Neurological Sciences 150 (September 1997): S173—S174. http://dx.doi.org/10.1016/s0022-510x(97)85703-6.

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MUTHUSAMY, V. V. "BR 08-3 MANAGEMENT OF DYSLIPIDEMIA IN HYPERTENSION." Journal of Hypertension 34, Supplement 1 (September 2016): e545. http://dx.doi.org/10.1097/01.hjh.0000501492.32355.c5.

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Walz, R., S. T. Terracciano, P. R. Wille, D. B. Nora, J. A. C. Ehlers, M. M. Bianchin, and S. R. Haussen. "3-40-08 Visual evoked potential in orbital pseudotumour." Journal of the Neurological Sciences 150 (September 1997): S197. http://dx.doi.org/10.1016/s0022-510x(97)85833-9.

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Bautin, Andrei, Anna Siganevich, Elena Malaya, Mikhail Gordeev, Evgenii Khomenko, Vladislav Solntsev, and Alexandr Marichev. "ASSA13-08-3 Influence of Cardiac Output on Sevoflurane Pharmacodynamics." Heart 99, Suppl 1 (April 2013): A36.2—A36. http://dx.doi.org/10.1136/heartjnl-2013-303992.111.

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Lylyk, P., A. Ferrario, and R. Ceratto. "3-07-08 Rendu-Osler-Weber (row) disease-endovascular therapeutic." Journal of the Neurological Sciences 150 (September 1997): S144. http://dx.doi.org/10.1016/s0022-510x(97)85548-7.

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"Mitteilungen 3/08." Der Ophthalmologe 105, no. 2 (February 2008): 207–8. http://dx.doi.org/10.1007/s00347-008-1722-2.

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"TOPIC 08-3 – Biomarkers." Archives of Cardiovascular Diseases Supplements 3 (May 2011): 46–48. http://dx.doi.org/10.1016/s1878-6480(11)70369-x.

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"Mitteilungen DGPPN 3/08." Der Nervenarzt 79, no. 3 (March 2008): 371–78. http://dx.doi.org/10.1007/s00115-008-2445-y.

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"10.1016/S0271-7964(08)70005-3." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.1016/s0271-7964(08)70005-3.

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Dissertations / Theses on the topic "303.48/3/08"

1

Kaye, Dan K. "Domestic violence during pregnancy in Uganda : the social context, biomedical consequences and relationship with induced abortion /." Kampala ; Stockholm, 2006. http://diss.kib.ki.se/2006/9970-867-08-3/.

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Chirico, Domenico <1966&gt. "Il presidente del consiglio dei ministri nell'ordinamento vigente e nelle prospettive di riforma." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6603/3/domenico_chirico_tesi.pdf.

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“Il Presidente del Consiglio dei Ministri nell'ordinamento vigente e nelle proposte di riforma”. La tesi si propone di ricostruire i caratteri propri della figura giuridica del Presidente del Consiglio nell’ordinamento vigente, sino alla analisi delle più recenti proposte di riforma costituzionale in tema. La dimensione analitico-sistematica proposta è stata sviluppata in riferimento alle concrete dinamiche economiche, politiche ed istituzionali, in relazione alle quali si è inteso verificare il tipo di rapporto tra esigenze di stabilizzazione del ciclo economico ed esigenze di stabilizzazione degli esecutivi, dando il dovuto rilievo al processo di integrazione della Unione Europea, come “motore” delle istanze di riforma del sistema economico ed istituzionale. Nel primo capitolo, si sono esplicitate le chiavi metodologiche secondo le quali si è inteso sviluppare il percorso di ricerca. Nel secondo capitolo si è operata una ricostruzione del quadro ordinamentale a base statutaria, come termine iniziale per poter cogliere al meglio la configurazione del ruolo poi assunta nell’ordinamento repubblicano; ciò come premessa necessaria ad una corretta ricostruzione diacronica, di tutti gli elementi rilevanti per poter comprendere la portata delle proposte attuali. Nel terzo capitolo, si è cercato di ricostruire il ruolo del presidente del consiglio, collocandolo nel quadro della dinamica attuazione/inattuazione dell’ordinamento repubblicano e alla luce dei caratteri del sistema politico, in modo da poter coniugare i tratti evolutivi imposti all’inquadramento della figura dalle dinamiche del sistema politico; così da poter conseguentemente cogliere gli elementi genetici di un dibattito politico istituzionale, che genera proposte di riforma organica, mediante l’analisi degli atti delle commissioni Parlamentari per le riforme. Nel quarto capitolo, a partire dalla apertura di una fase di c.d. “transizione”, si ricostruiscono le proposte specificamente finalizzate al riassetto del Presidente del Consiglio prodotte dalle commissioni parlamentari per le riforme, segnando le tappe di un percorso ancora aperto e dall’esito incerto.
The work analyses the institutional characters of the head of the government, in particular appointing the powers about his ministers and the powers of the government in Parliament, in connections with the legislative procedures. The analysis shows the importance of the party-system in conditioning the balance bitwin parliament and government. In particular, a plularistic asset of the party-sistem, based on a proportional electoral law, favourishes the weekness of the government. On this considerations, the istances of reform are oriented to enforce the government and simplify the party-system, in order to give as a result a “deciding democracy”, based on a strength Parliament and a strength Government.
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Agostini, Valentina <1982&gt. "La rete multidisciplinare dell'Emilia-Romagna per lo studio e la prevenzione della morte cardiaca improvvisa." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amsdottorato.unibo.it/9620/3/Agostini_Valentina_tesi.pdf.

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Nel 2018, alcuni professionisti dell’Azienda Sant’Orsola-Malpighi e dell’Università di Bologna hanno costituito un gruppo multidisciplinare con lo scopo di fornire una diagnosi eziologica nei casi di morte cardiaca improvvisa (MCI). Tutti i casi di MCI in soggetti di età > 1 anno e ≤ 55 anni sono stati sottoposti ad uno studio anatomo-patologico del cuore presso l’Unità di Patologia Cardiovascolare del Sant’Orsola-Malpighi. I casi con sospetta malattia genetica e i casi con cuore strutturalmente normale sono stati avviati ad analisi presso la Genetica Medica. In alcuni casi è stato necessario procedere ad indagini tossicologiche o microbiologiche. Ai familiari dei pazienti deceduti è stato successivamente offerto uno screening cardiologico clinico e strumentale. Nei due anni di attività sono giunti all’attenzione dell’Unità di Patologia Cardiovascolare 50 casi di MCI. L’età media dei soggetti è risultata 35±13.6 anni. Il 100% dei casi è stato sottoposto ad esame cardio-patologico completo, il 64% dei casi è stato sottoposto ad analisi genetica, il 44% ad indagini tossicologiche e il 4% ad indagini microbiologiche. L’approccio scelto ha permesso di raggiungere un elevato grado di certezza diagnostica nell’85.5% dei casi e, in particolare, una diagnosi certa è stata posta nel 60.5% dei casi. Nella nostra casistica le malattie non ischemiche del miocardio rappresentano la causa più frequente di MCI (39.9%). Fra queste le miocarditi/malattie infiammatorie del miocardio, sono il 42.3%. Le malattie coronariche sono risultate la causa della MCI nel 23.1% dei casi e la patologia dissecativa delle coronarie costituiva una percentuale consistente di questo sottogruppo (20%). I cuori strutturalmente normali rappresentano il 14.5% della nostra casistica. Le indagini tossicologiche hanno fornito un importante contributo. In 10 famiglie sono state proposte indagini di screening ai parenti di primo grado.
Nel 2018, alcuni professionisti dell’Azienda Sant’Orsola-Malpighi e dell’Università di Bologna hanno costituito un gruppo multidisciplinare con lo scopo di fornire una diagnosi eziologica nei casi di morte cardiaca improvvisa (MCI). Tutti i casi di MCI in soggetti di età > 1 anno e ≤ 55 anni sono stati sottoposti ad uno studio anatomo-patologico del cuore presso l’Unità di Patologia Cardiovascolare del Sant’Orsola-Malpighi. I casi con sospetta malattia genetica e i casi con cuore strutturalmente normale sono stati avviati ad analisi presso la Genetica Medica. In alcuni casi è stato necessario procedere ad indagini tossicologiche o microbiologiche. Ai familiari dei pazienti deceduti è stato successivamente offerto uno screening cardiologico clinico e strumentale. Nei due anni di attività sono giunti all’attenzione dell’Unità di Patologia Cardiovascolare 50 casi di MCI. L’età media dei soggetti è risultata 35±13.6 anni. Il 100% dei casi è stato sottoposto ad esame cardio-patologico completo, il 64% dei casi è stato sottoposto ad analisi genetica, il 44% ad indagini tossicologiche e il 4% ad indagini microbiologiche. L’approccio scelto ha permesso di raggiungere un elevato grado di certezza diagnostica nell’85.5% dei casi e, in particolare, una diagnosi certa è stata posta nel 60.5% dei casi. Nella nostra casistica le malattie non ischemiche del miocardio rappresentano la causa più frequente di MCI (39.9%). Fra queste le miocarditi/malattie infiammatorie del miocardio, sono il 42.3%. Le malattie coronariche sono risultate la causa della MCI nel 23.1% dei casi e la patologia dissecativa delle coronarie costituiva una percentuale consistente di questo sottogruppo (20%). I cuori strutturalmente normali rappresentano il 14.5% della nostra casistica. Le indagini tossicologiche hanno fornito un importante contributo. In 10 famiglie sono state proposte indagini di screening ai parenti di primo grado.
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Kirsten, Gerhardus Petrus <1994&gt. "Order reduction of semilinear differential matrix and tensor equations." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amsdottorato.unibo.it/10010/3/Final_AMS.pdf.

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In this thesis, we are interested in approximating, by model order reduction, the solution to large-scale matrix- or tensor-valued semilinear Ordinary Differential Equations (ODEs). Under specific hypotheses on the linear operators and the considered domain, these ODEs often stem from the space discretization on a tensor basis of semilinear Partial Differential Equations (PDEs) with a dimension greater than or equal to two. The bulk of this thesis is devoted to the case where the discrete system is a matrix equation. We consider separately the cases of general Lipschitz continuous nonlinear functions and the Differential Riccati Equation (DRE) with a quadratic nonlinear term. In both settings, we construct a pair of left-right approximation spaces that leads to a reduced semilinear matrix differential equation with the same structure as the original problem, which can be more rapidly integrated with matrix-oriented integrators. For the DRE, under certain assumptions on the data, we show that a reduction process onto rational Krylov subspaces obtains significant computational and memory savings as opposed to current approaches. In the more general setting, a challenging difference lies in selecting and constructing the two approximation bases to handle the nonlinear term effectively. In addition, the nonlinear term also needs to be approximated for efficiency. To this end, in the framework of the Proper Orthogonal Decomposition (POD) methodology and the Discrete Empirical Interpolation Method (DEIM), we derive a novel matrix-oriented reduction process leading to a practical, structure-aware low order approximation of the original problem. In the final part of the thesis, we consider the multidimensional setting. Here we extend the matrix-oriented POD-DEIM algorithm to the tensor setting and illustrate how we can apply it to systems of such equations. Moreover, we discuss how to integrate the reduced-order model and, in particular, how to solve the resulting tensor-valued linear systems.
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Brandoni, Domitilla <1994&gt. "Tensor-Train decomposition for image classification problems." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amsdottorato.unibo.it/10121/3/phd_thesis_DomitillaBrandoni_final.pdf.

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In these last years a great effort has been put in the development of new techniques for automatic object classification, also due to the consequences in many applications such as medical imaging or driverless cars. To this end, several mathematical models have been developed from logistic regression to neural networks. A crucial aspect of these so called classification algorithms is the use of algebraic tools to represent and approximate the input data. In this thesis, we examine two different models for image classification based on a particular tensor decomposition named Tensor-Train (TT) decomposition. The use of tensor approaches preserves the multidimensional structure of the data and the neighboring relations among pixels. Furthermore the Tensor-Train, differently from other tensor decompositions, does not suffer from the curse of dimensionality making it an extremely powerful strategy when dealing with high-dimensional data. It also allows data compression when combined with truncation strategies that reduce memory requirements without spoiling classification performance. The first model we propose is based on a direct decomposition of the database by means of the TT decomposition to find basis vectors used to classify a new object. The second model is a tensor dictionary learning model, based on the TT decomposition where the terms of the decomposition are estimated using a proximal alternating linearized minimization algorithm with a spectral stepsize.
Negli ultimi anni si è registrato un notevole sviluppo di nuove tecniche per il riconoscimento automatico di oggetti, anche dovuto alle possibili ricadute di tali avanzamenti nel campo medico o automobilistico. A tal fine sono stati sviluppati svariati modelli matematici dai metodi di regressione fino alle reti neurali. Un aspetto cruciale di questi cosiddetti algoritmi di classificazione è l'uso di aspetti algebrici per la rappresentazione e l'approssimazione dei dati in input. In questa tesi esamineremo due diversi modelli per la classificazione di immagini basati sulla decomposizione Tensor-Train (TT). In generale, l'uso di approcci tensoriali è fondamentale per preservare la struttura intrinsecamente multidimensionale dei dati. Inoltre l'occupazione di memoria per la decomposizione Tensor-Train non cresce esponenzialmente all'aumentare dei dati, a differenza di altre decomposizioni tensoriali. Questo la rende particolarmente adatta nel caso di dati di grandi dimensioni. Inoltre permette, attraverso l'uso di opportune strategie di troncamento, di limitare notevolmente l'occupazione di memoria senza ricadute negative sulle performance di classificazione. Il primo modello proposto in questa tesi è basato su una decomposizione diretta del database tramite la decomposizione TT. In questo modo viene determinata una base che verrà di seguito utilizzata nella classificazione di nuove immagini. Il secondo è invece un modello di dictionary learning tensoriale sempre basato sulla decomposizione TT in cui i termini della decomposizione sono determinati utilizzando un nuovo metodo di ottimizzazione alternato con l'utilizzo di passi spettrali.
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Guerrini, K. "DEVELOPMENT OF A LC/MS-MS METHOD FOR THE STUDY OF THE RATIOS BETWEEN MORPHINE, MORPHINE-3-beta-D-GLUCURONIDE AND MORPHINE-6-beta-D-GLUCURONIDE IN BLOOD SAMPLES FROM HEROIN FATALITIES"." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/170503.

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In heroin fatalities the diagnosis of the cause of death may be particularly difficult because of several reasons, such as the relationship between lethal dose and current individual tolerance, the complexity of heroin metabolism, the presence of systemic dysfunction, and the contemporary use of other drugs of abuse. Thus, a wide variability is present in post-mortem blood concentration of morphine (MOR), the main metabolite of heroin, which is usually the most important analytical result for the interpretation of the cause of death. Recently, increasing interest has grown towards the role of the metabolites morphine-3-β-D-glucuronide (M3G) and morphine-6-β-D-glucuronide (M6G) in mediating heroin effects. The aim of this PhD study has been the development of a LC/MS-MS method for the determination of MOR, M3G and M6G in autopsy blood samples. An ESI-QqQ Mass Spectrometer, operating in positive ionisation and MRM mode, was used. Chromatographic separation was achieved thanks to a Reversed-Phase method, using a C18 column and a gradient elution with a binary mobile phase. SPE technique was employed to extract the analytes from biological samples. After validation, the method was applied to twenty-five blood specimens collected from cases of suspected fatal heroin overdose. The concentrations and the molar ratios of MOR, M3G and M6G were investigated. The influence of some risk factors, such as the contemporary use of alcohol, methadone or cocaine, was also studied.
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Zhu, Boheng <1990&gt. "Promoting Weight Loss and Psychological Well-being in patients with obesity: A Sequential Combination of Behavioral Lifestyle and Well-Being Intervention." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amsdottorato.unibo.it/9561/3/Zhu_Boheng_tesi.pdf.

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Introduction: Behavioral lifestyle interventions focused on diet and physical activity are a cornerstone for the treatment of obesity. However, their effects vary substantially across individuals in terms of magnitude and durability. Personalized approaches that target psychological well-being may facilitate healthy behaviors and sustained weight loss. Objectives: This study aimed to explore whether the sequential combination of behavioral lifestyle and well-being intervention (BLI/WBI) may result in more favorable outcomes than behavioral lifestyle intervention alone (BLIA) in promoting weight loss (primary outcome) and improving psychological well-being, distress, dietary behaviors, and physical activity (secondary outcomes). Methods: 83 patients with obesity were randomly assigned to the BLI/WBI group (n=38) or the BLIA group (n=43). Participants in the BLIA group received a 12-week behavioral weight loss program, while those in the BLI/WBI received the same program followed by an additional 4-week well-being intervention. Data were collected at pretreatment (baseline, T1), at the end of BLI/WBI (T2), and at 6-month follow-up (T3). Results: There was a significant weight loss in both treatment groups at the end of BLI/WBI and 6-month follow-up. The BLI/WBI group showed greater improvements in anxiety symptoms (β=-1.92 [-3.66 to -0.18], p< 0.05) at the end of BLI/WBI and in depressive symptoms (β= -2.28[-4.20 to -0.37], p< 0.05) at 6-month follow-up compared to the BLIA group. Conclusions: The WBI showed no additional effect on weight loss. However, the secondary outcomes indicate that the WBI may reduce vulnerability to depressive and anxiety symptoms in obese patients. Future studies are needed to explore whether the psychological benefits of WBI can foster long-term weight loss maintenance.
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CARRARO, CATERINA. "Uso di tecnologie omiche per lo sviluppo di farmaci: studio su composti 3-cloropiperidinici." Doctoral thesis, Università degli studi di Padova, 2022. http://hdl.handle.net/11577/3442034.

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Tumor heterogeneity and complex resistance mechanisms undermine the therapeutic value of existing anticancer options, generating a pressing demand for alternative accessible and effective leads. In this sense, our group recently introduced 3-chloropiperidines (3-CePs) as a novel class of alkylating agents designed to improve the pharmacological profile of nitrogen mustard (NM) chemotherapeutics. Previous works described the improved alkylating properties of bifunctional 3-chloropiperidines (B-CePs) compared to the reference NM chlorambucil, exploring the effect of different linker structures on their reactivity with DNA and dissecting the mechanism of B-CePs alkylation at guanines. From these premises, this project further investigated the chemical space and antiproliferative value of these anticancer candidates. First, an explorative set of monofunctional analogues (M-CePs) was introduced to study the effect of a single reactive center on the activity of compounds. Notably, despite reduced DNA cleavage relative to the bifunctional compounds, these new agents showed nanomolar cytotoxicity indexes against test cancer cells, along with an unexpected tropism for a pancreatic adenocarcinoma cell line (BxPC-3), demonstrating to be valid alternatives for the future development of this class of compounds. Previous works showed that aromatic linkers decreased the alkylation potency compared to aliphatic analogues. Since classical nitrogen mustards with milder electrophilicity are known to be also less toxic in vivo, we further expanded our library of compounds with a new and enlarged set of aromatic B-CePs. Interestingly, aromatic agents exerted a remarkable activity against 2D and 3D cancer cell cultures as well as an exclusive tropism for BxPC-3 cells, as observed for M-CePs. As a general rule, slower reactivity and enhanced transported-mediated uptake profiles were demonstrated to boost cytotoxicity against the more complex model of three-dimensional spheroids. The tropism for pancreatic adenocarcinoma BxPC-3 cells was further observed for a third set of Lys-ester derivatives bearing appended instead of embedded aromatic linkers. In this other study, an extended set of derivatives bearing Lys-ester/amide linkers with various aromatic and aliphatic side chains was investigated in terms of cellular activity and consumption kinetics due to ring hydroxylation in aqueous solution, a competing reaction which abates the fraction of compound able to alkylate the biological target. Our results highlighted that the lower DNA reactivity of Lys-ester aromatic analogues was compensated by a longer stability to hydroxylation, allowing them to preserve valuable indexes of cytotoxicity. In the last work presented here, we investigated the molecular bases of the observed 3-CePs tropism for the pancreatic adenocarcinoma cell line. Representative mono- and bifunctional compounds were thoroughly analyzed by the use of a multi-omic approach to investigate the molecular determinants of cell susceptibility to our drug candidates. We analyzed transcriptional changes and chromatin status upon treatment in a high- (pancreatic adenocarcinoma BxPC-3) and low-sensitive (colorectal adenocarcinoma HCT-15) cancer cell lines, demonstrating that BxPC-3 cells were unable to control proteostasis and DNA damage response in stress conditions when exposed to our alkylating agents. Furthermore, we derived perturbation-informed signatures predicting compound sensitivity and identified potentially more susceptible target tumor types for the further development of clinical candidates. We believe that our results exemplify the potential of a multi-omic approach in offering a versatile framework to support drug discovery toward precision oncology.
Tumor heterogeneity and complex resistance mechanisms undermine the therapeutic value of existing anticancer options, generating a pressing demand for alternative accessible and effective leads. In this sense, our group recently introduced 3-chloropiperidines (3-CePs) as a novel class of alkylating agents designed to improve the pharmacological profile of nitrogen mustard (NM) chemotherapeutics. Previous works described the improved alkylating properties of bifunctional 3-chloropiperidines (B-CePs) compared to the reference NM chlorambucil, exploring the effect of different linker structures on their reactivity with DNA and dissecting the mechanism of B-CePs alkylation at guanines. From these premises, this project further investigated the chemical space and antiproliferative value of these anticancer candidates. First, an explorative set of monofunctional analogues (M-CePs) was introduced to study the effect of a single reactive center on the activity of compounds. Notably, despite reduced DNA cleavage relative to the bifunctional compounds, these new agents showed nanomolar cytotoxicity indexes against test cancer cells, along with an unexpected tropism for a pancreatic adenocarcinoma cell line (BxPC-3), demonstrating to be valid alternatives for the future development of this class of compounds. Previous works showed that aromatic linkers decreased the alkylation potency compared to aliphatic analogues. Since classical nitrogen mustards with milder electrophilicity are known to be also less toxic in vivo, we further expanded our library of compounds with a new and enlarged set of aromatic B-CePs. Interestingly, aromatic agents exerted a remarkable activity against 2D and 3D cancer cell cultures as well as an exclusive tropism for BxPC-3 cells, as observed for M-CePs. As a general rule, slower reactivity and enhanced transported-mediated uptake profiles were demonstrated to boost cytotoxicity against the more complex model of three-dimensional spheroids. The tropism for pancreatic adenocarcinoma BxPC-3 cells was further observed for a third set of Lys-ester derivatives bearing appended instead of embedded aromatic linkers. In this other study, an extended set of derivatives bearing Lys-ester/amide linkers with various aromatic and aliphatic side chains was investigated in terms of cellular activity and consumption kinetics due to ring hydroxylation in aqueous solution, a competing reaction which abates the fraction of compound able to alkylate the biological target. Our results highlighted that the lower DNA reactivity of Lys-ester aromatic analogues was compensated by a longer stability to hydroxylation, allowing them to preserve valuable indexes of cytotoxicity. In the last work presented here, we investigated the molecular bases of the observed 3-CePs tropism for the pancreatic adenocarcinoma cell line. Representative mono- and bifunctional compounds were thoroughly analyzed by the use of a multi-omic approach to investigate the molecular determinants of cell susceptibility to our drug candidates. We analyzed transcriptional changes and chromatin status upon treatment in a high- (pancreatic adenocarcinoma BxPC-3) and low-sensitive (colorectal adenocarcinoma HCT-15) cancer cell lines, demonstrating that BxPC-3 cells were unable to control proteostasis and DNA damage response in stress conditions when exposed to our alkylating agents. Furthermore, we derived perturbation-informed signatures predicting compound sensitivity and identified potentially more susceptible target tumor types for the further development of clinical candidates. We believe that our results exemplify the potential of a multi-omic approach in offering a versatile framework to support drug discovery toward precision oncology.
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9

Lanza, Leonardo <1986&gt. "IL JAZZ NEL VENETO: 3 MODELLI DI ORGANIZZAZIONE ARTISTICA NEL TERRITORIO." Master's Degree Thesis, Università Ca' Foscari Venezia, 2014. http://hdl.handle.net/10579/3982.

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Partendo da un'analisi preliminare dei processi improvvisativi che sono all'origine della musica Jazz, considero 3 diverse realtà organizzative del territorio veneziano che si occupano di promuovere e dare impulso a questo genere musicale: Veneto Jazz, Vicenza Jazz e Caligola, con una breve premessa introduttiva, in riferimento ad Umbria Jazz, la madre di tutti i Festival Jazz che si sono succeduti in Italia. L'obiettivo di studio dell'elaborato, è quello di mettere in evidenza per ognuna delle 3 diverse organizzazioni i seguenti elementi: i problemi organizzativi e di gestione, i problemi economico-finanziari, gli aspetti comunicativi e le ricadute extra-artistiche sul territorio (turismo e immagine), la considerazione sociologica (tipo di pubblico che accede a queste manifestazioni, il comportamento degli Enti locali nei confronti di queste organizzazioni artistiche (in che modo vengono finanziati i Festival Jazz in funzione delle politiche turistiche), la promozione dei musicisti italiani oltre ai già affermati musicisti americani.
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10

SPAGNUOLO, GAIA. "MARCATORI MOLECOLARI AD IMPATTO TRASLAZIONALE NEL CARCINOMA EPATOCELLULARE." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/217460.

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L’epatocarcinoma (EC) è un tumore maligno ad elevata morbilità e mortalità la cui speranza di cura è basata su diagnosi precoce e terapia individualizzata. Ad oggi il trattamento di elezione è rappresentato dalla chirurgia e l’unico farmaco con comprovata efficacia terapeutica è un presidio biologico di recente introduzione ad azione anti-tirosinochinasica (Sorafenib). La gestione ottimale del paziente con EC è sempre più influenzata dalla possibilità di disporre di marcatori molecolari da utilizzarsi nella pratica clinica a significato diagnostico, prognostico e predittivo. Il presente lavoro si propone come contributo all’identificazione e validazione di specifici indicatori biologici nella diagnostica del piccolo EC, predizione della recidiva del tumore resecato e della sensibilità individuale alla risposta al trattamento farmacologico nella forma avanzata. E già stato dimostrato che l’accuratezza della diagnosi precoce di EC su biopsia epatica puo’ essere migliorata in maniera significativa dalla valuatazione dell’espressione combinata di alcuni marcatori recentmente proposti e già utilizzati nella pratica clinica. Abbiamo cercato di ottimizzare questo pannello valutando il contributo aggiuntivo della catena pesante della clatrina (CHC) che è componente essenziale nel sistema di trasporto vescicolare intra ed extracellulare, già segnalato come sovraregolato negli epatociti tumorali maligni. Utilizzando una casistica di EC di piccole dimensioni e di lesioni precancerose di controllo e documentando l’espressione della molecola con tecnica immunocitochimica, abbiamo verificato la sua efficacia in termini di accuratezza diagnostica. In particolare l’introduzione di CHC si è dimostrata in grado di incrementare la sensibilità del pannello dal 46,8% al 63,8% a fronte del mantenimento di una specificità assoluta. E’ noto come il processo di carcinogenesi epatica origini anche sulla base di alterazioni delle vie molecolari che governano i processi di tipo ossidativo, con importante ruolo di protezione svolto dalla famiglia dei citocromi. Alcuni studi di espressione genica hanno già evidenziato che la recidiva di malattia tumorale nel fegato sia influenzata dalla disregolazione di alcuni citocromi, tra cui CYP1A2. Abbiamo inteso verificare e validare il ruolo del citocromo CYP1A2 nella qualità di possibile marcatore ad impatto traslazionale nella recidiva dell’EC attraverso il suo dosaggio immuncitochimico nel parenchima epatico non tumorale. Utilizzando una casistica omogenea di pazienti portatori di EC ad eziologia virale (virus C dell’epatite) e a follow-up noto, il dosaggio di CYP1A2 è risultato associato in maniera statisticamente significativa, sia in analisi univariata che multivariata al tempo libero da recidiva tumorale (p=0.012). In particolare la ridotta espressione del citocromo negli epatociti non tumorali, interpretabile come background più suscettibile alla trasformazione neoplastica “de novo”, risultava in grado di predire una più rapida ripresa della malattia. La terapia farmacologica dell’EC è attualmente somministrata a pazienti portatori di forme avanzate senza tenere conto della reale e individuale suscettibilità all’azione del farmaco. Vi è una forte esigenza clinica di selezionare i pazienti candidabili al trattamento anche per gli elevati costi della terapia, ma nessun marcatore, sia esso tissutale o sierologico, si è rivelato ad oggi capace di soddisfare questi requisiti. Abbiamo inteso esplorare se i miRNA, che costituiscono una famiglia eterogenea ma fondamentale di molecole regolatrici della traduzione, potessero a loro volta candidarsi a possibili marcatori biologici di predizione della sensibilità al trattamento farmacologico dell’EC. A questo scopo, partendo da un pool amplissimo di miRNA, abbiamo proceduto ad una loro progressiva selezione sulla base della loro disregolazione nonchè associazione con il tempo di progressione della malattia dopo trattamento. Lo studio è stato condotto su biopsie epatiche pretrattamento di EC di pazienti omogeneamente trattati con Sorafenib. La selezione delle molecole e la validazione delle stesse è stata condotta in due casistiche distinte di cui la seconda utilizzata come coorte di validazione. Abbiamo cosi potuto individuare un unico miRNA con meccanismo di azione e geni targets poco conosciuti, il cui sovradosaggio valutato con tecnica di real-time PCR risultava fortemente e statisticamente associato ad una prolungata stabilizzazione della malattia tumorale (p=0.009). L’insieme di questi risultati dimostra che la crescente domanda di marcatori di medicina personalizzata per ottimizzare la gestione del paziente oncologico (con EC nel nostro caso), possa essere soddisfatta attraverso l’applicazione di tecniche relativamente semplici e riproducibili quali l’immunocitochimica e l’analisi quantitativa del messaggero, condotte sia su tessuti tumorali che non tumorali. Naturalmente affinchè il dosaggio di una molecola possa entrare nella pratica clinica corrente, candidandosi come un autentico marcatore molecolare, è necessaria, come nei nostri casi, un’ulteriore validazione in studi di tipo prospettico.
Hepatocellular carcinoma (HCC) is a malignant tumor with high morbidity and mortality worldwide. The treatment is based on early diagnosis and individualized therapy. Today surgery is the primary strategy for patients with HCC and Sorafenib, an anti tyrosine kinase drug, represents the only available drug with proven efficacy. The discovery of new molecular markers (diagnostic, prognostic and predictive) that can be translate in the clinical practice represents the improvement in the management of these patients. The present research is aimed at identifying and validating biological markers related to the early HCC diagnosis and to predict HCC relapse. In addition the individual sensibility to pharmacological treatment in patients with advanced HCC is also evaluated. It has been shown that the accuracy of the HCC early diagnosis on the liver biopsy can be significantly improved by combining histological features with molecular markers, recently proposed and applied in the clinical practice. We have optimized this molecular panel for evaluating the contribution of the clathrin heavy chain (CHC), which is an essential component of intra and extracellular vesicular transport, and previously reported as an up-regulated molecule in malignant liver cells. Using a series of small HCC and control precancerous lesions we tested, by immunohistochemical analysis, whether CHC expression contribute to improve the histopathological diagnostic accuracy. We found that the introduction of CHC increases the sensitivity from 46,8% to 63,8% and maintains an absolute specificity. It is now ascertained that hepatocarcinogenesis is based on alterations in a wide variety of molecular pathways controlling oxidative processes and that cytochromes family plays a protective role in this context. Additionally, gene expression profiles have shown that relapse of HCC is caused by some cytochromes deregulations (i.e. CYP1A2). We verified and validated the CYP1A2 role in relation to relapse of disease by immunohistochemistry and its quantification in non-tumoral liver parenchyma. By investigating a homogeneous series of HCC patients with HCV infection and known follow-up, we demonstrated that the CYP1A2 dosage was associated with the recurrence-free survival (p=0,012) in both univariate and multivariate analyses. Moreover, CYP1A2 expression decreased in non-tumoral hepatocytes, the most susceptible background to “de novo” neoplastic transformation, predicted a faster recurrence of disease. The pharmacological therapy of HCC is currently administered to patients with advanced disease, without any discrimination according to the individual drug susceptibility. There is a compelling clinical need to select patients more suitable to underwent pharmacological treatment, because of the elevated cost. Furthemore, there is no still histological and/or serological biomarker, capable to satisfy these requirements. For this reason, we explored whether miRNA, heterogeneous family of regulatory molecules of translation, can be used as new molecular predictive markers of sensitivity to HCC treatment. For this purpose, starting from a wide pool of miRNA, we progressively selected those deregulated and associated with time to progression of disease after treatment. This research was conducted on liver biopsies sampled before treatment in patients treated with Sorafenib. The selection and validation of miRNA were conducted on two distinct series of patients. Among these the second group of patients has been used as a validation set. We identified a single miRNA, with mechanism of action ad genes target unknown, which when appears overexpressed, by real-time PCR analysis, was strongly and statistically associated with prolonged stabilization of tumor disease (p=0,009). The above findings all suggest that the increasing demand for customized markers to optimized the management of HCC patients can be investigated through the application of relatively simple and reproducibly techniques (including immunohistochemistry and real-time PCR) on both tumoral and non-tumoral tissue. Further validation in prospective studies is required to pursue a personalized dosage of new molecular markers to be introduced in the current clinical practice.
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Books on the topic "303.48/3/08"

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Books, Switchback, ed. 1/3/08: P.F.S. Presents: Announcement: On the Switchback Books blog. Chicago, Illinois: Switchback Books, 2007.

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Ohio Genealogical Society. Fulton County Chapter. Fulton County, Ohio, birth records transcriptions: Book #3 1902-08 & 1920-24. Swanton, Ohio: Fulton County Chapter of the Ohio Genealogical Society, 2009.

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Ohio Genealogical Society. Fulton County Chapter. Fulton County, Ohio, death records transcriptions: Book #3 1902-08 & 1920-24. Swanton, Ohio: Fulton County Chapter of the Ohio Genealogical Society, 2009.

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H, Marwan S., and Indonesia. Kejaksaan Negeri (Banda Aceh), eds. Surat dakwaan no. reg. perk. 08/SUBV/BACEH/3/1991, terdakwa, nama lengkap Marwan, S.H. ... [Banda Aceh]: Kejaksaan Negeri Banda Aceh, 1991.

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Sawyer, Larry. P.F.S. Presents (Philly Free School Presents),1/3/08 readers in P.F.S. Post: From P.F.S. Post anthology. Edited by Adam Fieled. Philadelphia, PA: P.F.S. Post, 2007.

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Eliasson, Olafur. Olafur Eliasson : life in space 3 : 09.05.2008: [Zumtobel Group annual report [=] Geschäftsbericht : facts & figures [=] Zahlen & Fakten 2007/08. Edited by Engberg-Pedersen Anna and Studio Olafur Eliasson. Dornbirn: Zumtobel, 2008.

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Halle, Steve. P.F.S. Presents, Philly Free School Presents, Andersonville, Chicago, 1/3/08 readers in P.F.S. Post: From P.F.S. Post anthology. Edited by Adam Fieled. Philadelphia, PA: P.F.S. Post, 2007.

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Ларионова, О. Н. Лабиринт для троглодитов. Ленинград: Детская литература, 1991.

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Ларионова, О. Н. Лабиринт для троглодитов. Ленинград: Детская литература, 1991.

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Україна, Закони. Закони України. Vol. 6. Київ: Інститут законодавства Верховної Ради України, 1996.

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Book chapters on the topic "303.48/3/08"

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Abad, LI, Ben Martínez, S. Valencia, A. Gaupp, W. Gudat, and Ll Balcells. "Surface Resistance of La2/3Ca1/3MnO3 Epitaxial Thin Films Grown on Top of LaAlO3." In Advances in Science and Technology, 87–92. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-08-7.87.

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Abad, LI, V. Laukhin, S. Valencia, M. Varela, Ll Balcells, and Ben Martínez. "Structural and Magnetotransport Properties of Coherently Strained La2/3Ca1/3MnO3 Epitaxial Thin Films." In Advances in Science and Technology, 81–86. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-08-7.81.

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Turek, Ilja, K. Carva, and J. Kudrnovsky. "Transport Properties of (Ga,Mn)As Diluted Magnetic Semiconductors in the Bulk and in Layered Systems." In Advances in Science and Technology, 1–10. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-08-7.1.

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Ustinov, V. V., L. N. Romashev, M. A. Milyaev, T. P. Krinitsina, and A. M. Burkhanov. "Metamagnetic Transitions and Stepwise GMR in Uniaxial Fe/Cr Superlattices." In Advances in Science and Technology, 104–9. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-08-7.104.

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Continenza, Alessandra, Silvia Picozzi, Gianni Profeta, Luca Ottaviano, Maurizio Passacantando, Franco D'Orazio, and Franco Lucari. "First-Principles Approach to Mn-Doped Group IV Semiconductors: Comparison with Experiments and Outlook." In Advances in Science and Technology, 11–20. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-08-7.11.

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Castellano, Carlo, A. Martinelli, M. Ferretti, M. R. Cimberle, R. Cantelli, and Francesco Cordero. "Local Structure and Dynamic Properties of Mn Substituted Manganites Studied by EXAFS and Anelastic Spectroscopy." In Advances in Science and Technology, 110–15. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-08-7.110.

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Da Costa, Victor, and M. Romeo. "Disorder Effects on Tunneling Junctions." In Advances in Science and Technology, 116–20. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-08-7.116.

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Auslender, M. "A Magnetoelectric Effect in Low-Carrier Density Colossal Magnetoresistance Materials." In Advances in Science and Technology, 21–26. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-08-7.21.

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Zhang, Yue Bin, Thirumany Sritharan, and Sean Li. "Isolated and Grouped Co Spins in Polycrystalline Zn1-xCoxO Oxides." In Advances in Science and Technology, 27–30. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-08-7.27.

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Banerjee, Pushan, and B. Ghosh. "A Contacting Technology to Magnetic Semiconductors." In Advances in Science and Technology, 31–35. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-08-7.31.

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Conference papers on the topic "303.48/3/08"

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"IEEE SoutheastCon 08 Huntsville, Alabama April 3–6." In IEEE SoutheastCon 2008. IEEE, 2008. http://dx.doi.org/10.1109/secon.2008.4494236.

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Troxell, ML, D. Ang, A. Warrick, C. Beadling, and CL Corless. "Abstract P2-08-03: Phosphatidylinositol-3-kinase mutations are common in lobular neoplasia." In Abstracts: Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012; San Antonio, TX. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/0008-5472.sabcs12-p2-08-03.

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Бондарь, С. С. "Мониторинг функционального состояния внутренних органов у пациентов с пневмонией методом активной радиометрии." In ТЕНДЕНЦИИ РАЗВИТИЯ НАУКИ И ОБРАЗОВАНИЯ. «Л-Журнал», 2016. http://dx.doi.org/10.18411/lj2016-3-08.

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Pursley, Jacob, Tyler Soenen, Curtis Maxon, Nicholas Putnam, and Patrick Thomas. "Lower Length Scale Informed Continuum Modeling of Femtosecond Laser Processing." In American Physical Society March Meeting, American Physical Society, 3/03/2024-3/08/2024 Minneapolis, MN Minneapolis Convention Center. US DOE, 2024. http://dx.doi.org/10.2172/2318647.

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Воробйова, О. "ПОТЕНЦІАЛ РОЗВИТКУ ЗАПОВІДНОГО ФОНДУ ОДЕСЬКОЇ ОБЛАСТІ ЯК ТЕРИТОРІАЛЬНОГО ПРИРОДНОГО АКТИВУ." In Об’єкти природно-заповідного фонду України: сучасний стан та шляхи забезпечення ефективної їх діяльності. Національний природний парк «Мале Полісся», 2023. http://dx.doi.org/10.61584/3-4-08-2023-3.

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Burugu, S., D. Gao, and TO Nielsen. "Abstract PD5-08: Expression of LAG-3 in breast cancer, and its association with subtype and outcome." In Abstracts: 2016 San Antonio Breast Cancer Symposium; December 6-10, 2016; San Antonio, Texas. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.sabcs16-pd5-08.

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Sims, JD, M. Taguaim, C. Hanson, X. Cui, and LK Medina-Kauwe. "Abstract P5-08-08: A human epidermal growth factor receptor 3 (HER3)-binding nanoparticle targets and kills Herceptin®-resistant human epidermal growth factor receptor 2 (HER2)-positive breast cancer." In Abstracts: Thirty-Sixth Annual CTRC-AACR San Antonio Breast Cancer Symposium - Dec 10-14, 2013; San Antonio, TX. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/0008-5472.sabcs13-p5-08-08.

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Нелаева, Ю. В., А. А. Нелаева, А. Е. Южакова, А. А. Вердиева, А. Ш. Амирова, А. В. Бучельникова, and А. А. Вострикова. "ЦИРКАДИАННЫЕ РИТМЫ И ИХ ВЛИЯНИЕ НА МЕТАБОЛИЧЕСКИЕ ПОКАЗАТЕЛИ ПРИ НАРУШЕНИИ УГЛЕВОДНОГО ОБМЕНА." In Сборник тезисов III Конференции по лечению и диагностике сахарного диабета «Фундаментальная и клиническая диабетология в 21 веке: от теории к практике». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/diaconfiii25-26.05.23-72.

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Abstract:
ЦЕЛЬ: проанализировать результаты анкетирования видов хронотипов, степени физической адаптации, особенностей организации сна и бодрствования у лиц с нарушением углеводного обмена (НУО). МАТЕРИАЛЫ И МЕТОДЫ: пациенты были распределены на 5 групп: 1 группа (n-80) – контрольная без висцерального ожирения, 2 группа (n-80) – лица с ожирением, 3 группа (n-80) – лица с предиабетом, 4 группа (n-80) – лица с сахарным диабетом 2 типа (СД2) с длительностью заболевания до 5 лет и 5 группа (n-80) – лица с СД2 с микроангиопатиями. Среднее значение окружности талии в группах с ожирением и НУО составило 98,6±3,4 см – висцеральное ожирение. Среди исследуемых лиц 77% женщин и 23% муж- чин, средний возраст – 58,6±3 лет. Анкетирование проводилось по опросникам: Horne-Austberga, IPAQ, MCTQ и PSQI. РЕЗУЛЬТАТЫ: по результатам теста Horne-Austberga во всех группах преобладает промежуточный хронотип: наибольшее количество – в группе с предиабетом (89%), а наименьшее – с СД2 до 5 лет (43%). Во всех группах наблюдался поздний отход ко сну: 1 группа – 23:30–01:00, 2 группа – 22:45–00:50, 3 группа — 22:55–00:30, 4 группа – 22:35–00:30 и 5 группа – 22:40–00:29, с увеличением продолжительности сна до 08:03, 08:24, 08:15, 09:00, 08:37 соответственно. По данным опросника IPAQ в контрольной группе у 100% – доста- точный уровень физической активности. Доля пациентов с гиподинамией в возрасте 40–65 лет преобла- дала в группе с предиабетом (88%), старше 65 лет – в группе с СД2 с микроангиопатиями (54%). Результаты Мюнхенского теста демонстрируют смещение времени засыпания и пробуждения на позднее время в рабо- чие и выходные дни: тенденция наибольшего смещения наблюдалась в группах с НУО – на 76 и 42 минуты соответственно, а наименьшего – в контрольной группе здоровых – на 27 и 33 минуты. При анализе данных Мюнхенского и Питтсбургского тестов выявлены особенности в расхождении между временем засыпания и пробуждения на 41 и 21 минуты только в группе с СД2 с микроангиопатиями. ВЫВОДЫ: преобладание промежуточного хронотипа во всех исследуемых группах, позднее время пробуждения и засыпания, увеличение продолжительности сна, хроническая разница между эндогенными часами в рабочие и выходные дни при наличии факторов риска (висцеральное ожирение, гиподинамия) свидетельствуют в пользу формирующегося «джетлага» и опосредованно повышают риск прогрессиро- вания НУО. Изменения качества сна за последний 1 месяц (по результатам опросника PSQI) может быть обусловлено современным ритмом жизни и связано со снижением адаптационных механизмов в поддер- жании метаболического равновесия. Десинхроноз является одним из дополнительных факторов риска развития НУО. Дальнейшее изучение циркадианных ритмов позволит персонализировано подходить к прогнозированию НУО при осуществлении профилактических мероприятий.
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Nanda, Swagat, Sapna Kumari, and Rudra Sankar Dhar. "Design and Performance Analysis of 3-Fin 08 nm Physical Gate Length SOI FinFETs Employing Gate Stacked High-K Dielectrics." In 2023 IEEE 3rd International Conference on Applied Electromagnetics, Signal Processing, & Communication (AESPC). IEEE, 2023. http://dx.doi.org/10.1109/aespc59761.2023.10390364.

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Кумпан, Н. А., and Е. А. Агапова. "К проблеме эмиграции и адаптации русских граждан в США." In ТЕНДЕНЦИИ РАЗВИТИЯ НАУКИ И ОБРАЗОВАНИЯ. НИЦ «Л-Журнал», 2016. http://dx.doi.org/10.18411/lj2016-5-3-08.

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Reports on the topic "303.48/3/08"

1

Raymond, David J. Use of NRL P-3 and ELDORA in TPARC/TCS-08. Fort Belvoir, VA: Defense Technical Information Center, September 2009. http://dx.doi.org/10.21236/ada531417.

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Raymond, David J. Use of NRL P-3 and ELDORA in TPARC/TCS-08. Fort Belvoir, VA: Defense Technical Information Center, September 2008. http://dx.doi.org/10.21236/ada532956.

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Raymond, David J. Use of NRL P-3 and ELDORA in TPARC/TCS-08. Fort Belvoir, VA: Defense Technical Information Center, September 2010. http://dx.doi.org/10.21236/ada542063.

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Robertson, A. Second generation PFBC systems R and D - Phase 2 and Phase 3. Monthly technical report, 08/01/1999--08/31/1999. Office of Scientific and Technical Information (OSTI), September 1999. http://dx.doi.org/10.2172/774497.

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Murphy, Dennis. CSL Issue Paper. March 2008, Volume 3-08. New Media and the Warfighter. Workshop Initial Impressions. Fort Belvoir, VA: Defense Technical Information Center, March 2008. http://dx.doi.org/10.21236/ada484350.

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ARMY ENGINEER SCHOOL FORT LEONARD WOOD MO. Engineer: The Professional Bulletin of Army Engineers. Volume 38, PB 5-08-3/4, July-December 2008. Fort Belvoir, VA: Defense Technical Information Center, December 2008. http://dx.doi.org/10.21236/ada495976.

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7

Wilcox, S. Solar Technology Validation Project - Iberdrola Renewables, Inc.: Cooperative Research and Development Final Report, CRADA Number CRD-08-298-3. Office of Scientific and Technical Information (OSTI), August 2013. http://dx.doi.org/10.2172/1090971.

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8

Lamontagne, M., P. Archambault, and S. Halchuk. Macroseismic information for the seven largest moderate earthquakes of the Charlevoix seismic zone, Quebec, between 1870 and 2021: February 3, 1902, M 4.5; September 30, 1924, M 5.2; January 08, 1931, M 4.9; October 19, 1939, M 5.3; October 14, 1952, M 4.5; August 19, 1979, M 4.8; March 6, 2005, M 4.7. Natural Resources Canada/CMSS/Information Management, 2021. http://dx.doi.org/10.4095/329135.

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Abstract:
This Open File Report provides the available macroseismic information for the seven largest moderate earthquakes that occurred in the Charlevoix Seismic Zone between 1870 and 2021. These earthquakes and their moment magnitude (M) are: 1) February 3, 1902, M 4.5; 2) September 30, 1924, M 5.2; 3) January 08, 1931, M 4.9; 4) October 19, 1939, M 5.3; 5) October 14, 1952, M 4.5; 6) August 19, 1979, M 4.8; 7) March 6, 2005, M 4.7. Five, possibly six, of these seven earthquakes occurred in the northeast portion of the CSZ, where the largest event of the period, the 1925 M 6.2 earthquake, also occurred. For each locality where the earthquakes were felt, macroseismic information is given and interpreted on the Modified Mercalli Intensity Scale. The original mail questionnaires filled by postmasters for earthquakes no. 3, 4, 5 and 6 are lost. Consequently, the main sources of information are the newspaper accounts except for no. 7 for which web-based questionnaires are available. The macroseismic information from localities in Canada and in the US (from NOAA) are tabulated in Microsoft Excel spreadsheets. Most newspaper clippings that have macroseismic information are included. The Open File also provides Google Earth kmz files that allow the felt information reports to be viewed in a spatial tool.
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9

Kerber, Steve, and Derek Alkonis. Lahaina Fire Comprehensive Timeline Report. UL Research Institutes, April 2024. http://dx.doi.org/10.54206/102376/vqkq5427.

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On August 8-9, 2023, the town of Lahaina, Hawaiʻi (on the island of Maui), endured a devastating fire fueled by environmental conditions, leading to 101 fatalities, widespread destruction, and devastating community impacts. The Fire Safety Research Institute (FSRI) conducted an extensive data collection effort to establish a comprehensive timeline and fact base around the Lahaina fires. This Lahaina Fire Comprehensive Timeline Report (Phase 1) report focuses on the events that occurred prior to, during, and immediately following the Lahaina fire, such as preparedness efforts, weather and its impact to infrastructure, and other fires occurring on Maui for the time period beginning at 14:55 (2:55 p.m. HST) on August 8, 2023, and concluding at 08:30 (8:30 a.m.) on August 9, 2023. Data from the three (3) other Maui fires is also included in specific sections to give context to the situation in Lahaina.
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10

Turnquist, Michael. PR460-223602-R01 Response to Corrosion Intersecting the Longitudinal Seam in Liquid Pipelines. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), June 2024. http://dx.doi.org/10.55274/r0000069.

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The primary objectives of project EC-02-13 "Response to Corrosion Interacting with the Longitudinal Seam in Liquid Pipelines" are to clarify what analysis methodologies are appropriate to assess corrosion intersecting a pipeline longitudinal seam weld (LSW) and to develop recommended guidelines to effectively manage these types of features. The overall project scope included execution of destructive testing of corrosion features intersecting an LSW, material property testing of LSWs produced by multiple manufacturing methods, detailed engineering analysis, and a literature review of all past relevant research. This project is funded by the Crack Management Strategic Research Priority (SRP) and is being executed in parallel with sibling projects EC-02-12 "Evaluation of Selective Seam Weld Corrosion Susceptibility," NDE-4-13 "Selective Seam Weld Corrosion Detection with In-line Inspection Technologies," IM-3-03 "Comprehensive Review and Assessment Guidelines for SSWC," IM-1-08 "Pragmatic Application of MegaRule RIN 1 - 192.712 Toughness Values," and NDE-2-15 "SSWC Identification, Sizing, and Measuring Grooving Ratio In the Ditch."
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