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Journal articles on the topic "301/.092 b"

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Togari, K., and M. Akasaka. "Okhotskite, a new mineral, an Mn3+-dominant member of the pumpellyite group, from the Kokuriki mine, Hokkaido, Japan." Mineralogical Magazine 51, no. 362 (October 1987): 611–14. http://dx.doi.org/10.1180/minmag.1987.051.362.17.

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AbstractOkhotskite, an Mn3+-dominant pumpellyite-group mineral, is monoclinic, A2/m, a = 8.887, b = 6.000, c = 19.55 Å, β = 97.08°, Z = 1. The formula is(Ca7.63Na0.17K0.01)Σ7.81(Mn2.752+Mg1.10)Σ3.85(Mn4.503+Al1.87Fe1.613+Ti0.02)Σ8.00Si12.13O39.71(OH)16.29,which simplifies to Ca8(Mn2+,Mg)4(Mn3+,Al,Fe3+)8Si12O5∂-n(OH)n. Strong lines in the X-ray powder diffraction pattern are: 4.76(60)(004, 111), 3.87(70)(202), 2.96(100)(115, 300), 2.88(25)(022), 2.72(70)(302), 2.67(45)(3̄04, 3̄11), 2.55(45)(024, 3̄13) and 2.38(45)(304).Its colour is deep orange with a pale orange streak and vitreous lustre. Transparent. Non-fluorescent. H6 (Mohs). Density (calc.) = 3.40 g/cm3. Optically biaxial negative, 2V(meas) = 46(5)°, 2V(calc) = 46°, dispersion indiscernible. Refractive indices: α = 1.782(5), β = 1.820(5), γ = 1.827(5). Orientation: Y = b, c∧Z = 9–14° in acute angle of β. Pleochroism is distinct: X yellow, Y and Z deep orange. Absorption: X < Y < Z.This mineral occurs as fine prisms up to 0.2 mm long and forms aggregates in network veinlets cutting hematite ore from the Kokuriki mine in the Tokoro district, eastern Hokkaido, Japan. Associated minerals are: hematite, piemontite, quartz, neotocite, bementite, apatite, Mn-oxides, inesite and rhodochrosite. The mineral is named okhotskite for the Sea of Okhotsk, along which the mine is located.
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Lazo Herrera, Luis Alberto, Bradly León Sánchez, Frank Hernández-García, Ignacio Robaina-Castillo, and Gicela Díaz Pita. "Multimedia educativa para el aprendizaje de la acupuntura y digitopuntura por estudiantes de Medicina." Investigación en Educación Médica, no. 32 (October 17, 2019): 51–60. http://dx.doi.org/10.22201/facmed.20075057e.2019.32.18155.

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Introducción: La Medicina Natural y Tradicional se aplica en Cuba como estrategia curricular en la carrera de medicina, constituyendo las tecnologías de la información y las comunicaciones uno de los métodos efectivos para su aplicación. Objetivo: Confeccionar una multimedia educativa para el aprendizaje de la acupuntura y digitopuntura por estudiantes de medicina. Método: Se realizó un estudio de desarrollo tecnológico en la Universidad de Ciencias Médicas de Pinar del Río, de septiembre de 2017 a enero de 2018. Para la confección de la multimedia se identificaron como etapas de trabajo la búsqueda y recopilación de información, la selección de herramientas y el diseño. Se validó el producto mediante criterios aportados por 18 expertos en la materia. Se evaluó la efectividad de la utilización del producto mediante un experimento pedagógico a los 28 estudiantes que integraron la muestra. Resultados: La multimedia muestra un diseño claro y atractivo. Ofrece una libre navegación donde se puede llegar, rápido y fácilmente al contenido deseado. En su totalidad los expertos evaluaron el producto de «muy adecuado», y todos los usuarios emitieron criterios de «bien» en los indicadores «Facilidad», «Funcionalidad» y «Originalidad», además de presentarse un comportamiento similar en los restantes. Al aplicar el Test de McNemar, todos los valores dieron significativos, demostrándose la efectividad de la herramienta elaborada. Conclusiones: La herramienta confeccionada permitió al estudiante de la carrera de medicina interactuar con los contenidos de la acupuntura y la digitopuntura, considerándose útil como material de apoyo en la docencia. Introducción La idea suicida consiste en el pensamiento de acabar con la propia existencia, el intento de suicidio, es la autoagresión llevada a cabo con la intención de morir que no resulta en la muerte del individuo. La idea e intento de suicidio es un problema multifactorial, resulta de una compleja interacción de factores biológicos, genéticos, psicológicos, económicos, sociológicos y ambientales, considerados factores de riesgo. Objetivo Identificar los factores de riesgo, idea e intento suicida, en estudiantes de medicina antes al iniciar el internado médico de pregrado en una universidad mexicana. Método Se trata de un estudio prospectivo, transversal, descriptivo, el análisis estadístico se realizó con el programa SPSS y se obtuvieron medidas de frecuencia simple, proporciones y medidas de tendencia central. Se utilizó T de student y Tau de Kendal, Rho de Spearman, y Pearson, y un valor < de 0.05 para correlación. Resultados Se encuestaron 740 alumnos, Hombres el 37.02%, Mujeres el 62.97%. Se identificaron los factores de riesgo, el total de los que contestaron tener idea suicida fueron 301 el 40.67%, intento suicida 52 el 7.02%. De acuerdo a la prueba T de student los valores fueron iguales para hombres y mujeres, con un nivel de significancia en la idea suicida de .092, y el intento suicida de .238, en cuanto a la correlaciones con las pruebas Tau b de Kendall la correlación es significativa en el nivel de 0.01 (bilateral), y Rho de Spearman la correlación es significativa en el nivel de 0.05 (bilateral), la correlación con la prueba de Pearson es significativa en el nivel 0.01 (bilateral) Conclusiones Identificamos los factores de riesgo, encontramos una correlación positiva entre idea e intento suicida, y consideramos que nuestro estudio podría ser la base de próximas investigaciones, para realizar detección temprana, tratamiento y seguimiento de los alumnos.
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Ha, Heon-Young, Jae Jang, Tae-Ho Lee, Chihyoung Won, Chang-Hoon Lee, Joonoh Moon, and Chang-Geun Lee. "Investigation of the Localized Corrosion and Passive Behavior of Type 304 Stainless Steels with 0.2–1.8 wt % B." Materials 11, no. 11 (October 25, 2018): 2097. http://dx.doi.org/10.3390/ma11112097.

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The pitting corrosion resistance and passive behavior of type 304 borated stainless steels (Febalance–18Cr–12Ni–1.5Mn–(0.19, 0.78, and 1.76 wt %)B) manufactured through conventional ingot metallurgy were investigated. The alloys were composed of an austenitic matrix and Cr2B phase, and the volume fraction of Cr2B increased from 1.68 to 22.66 vol % as the B content increased from 0.19 to 1.76 wt %. Potentiodynamic polarization tests measured in aqueous NaCl solutions revealed that the pitting corrosion resistance was reduced as the B content increased and the pits were initiated at the matrix adjacent to the Cr2B phase. It was found that the reduced resistance to pitting corrosion by B addition was due to the formation of more defective and thinner passive film and increased pit initiation sites in the matrix.
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Pirner, Maddison, Scott Doyle, Janna Mantua, Alexxa Bessey, Jacob Naylor, Bradley Ritland, Walter Sowden, Tina Burke, and Ashlee Mckeon. "307 Sleep and occupational wellbeing in active duty U.S Army Soldiers." Sleep 44, Supplement_2 (May 1, 2021): A122—A123. http://dx.doi.org/10.1093/sleep/zsab072.306.

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Abstract Introduction Insufficient sleep is ubiquitous among active duty service members in operational settings. Although insufficient sleep has been linked to poor cognitive, psychological, and physiological outcomes in military populations, little research has investigated the impact of insufficient sleep on Soldier occupational wellbeing. This study examined the longitudinal association between sleep quality and occupational functioning in a population of active duty U.S. Army Soldiers. Methods Sixty male Soldiers (age 25.41±3.74 years) participated. Sleep quality and occupational outcomes were assessed four weeks apart (before and after an annual training mission). Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Occupational outcome measures included the Emotional Exhaustion Scale, Walter Reed Functional Impairment Short Scale, Role Overload Scale, and Perceived Stress Scale. Linear regressions assessed the prediction of PSQI Global Score on occupational outcome scores. Student’s t-tests compared occupational outcomes between “good” and “poor” sleepers (PSQI Global Score &gt; 5 = poor sleeper). Results Poorer sleep quality at baseline broadly predicted poor occupational outcomes post-training. Specifically, higher PSQI Global Scores predicted higher emotional exhaustion (B = 1.6, p &lt; 0.001, R2 = 0.25), functional impairment (B = 0.29, p &lt; 0.03, R2 = 0.14), role overload (B = 28, p &lt; 0.008, R2 = 0.12), and perceived stress (B = 0.34, p &lt; 0.004, R2 = 0.2). Furthermore, occupational outcome scores were significantly higher in poor sleepers than good sleepers: emotional exhaustion: (t(58) = -4.18, p &lt; .001); functional impairment: (t(59) = -3.68, p = .001); role overload (t(58) = -3.20, p = .002); and perceived stress (t(58) = -2.43, p = .02). Conclusion This study identified a longitudinal relationship between sleep quality and occupational outcomes, suggesting that service members with poor sleep may be at risk for experiencing poor workplace wellbeing. Given the association between service member wellbeing and likelihood to re-enlist, insufficient sleep may negatively impact Soldier attrition. Future studies should aim to augment sleep quality and track occupational outcomes in this population. Support (if any) This work was funded by the Military Operational Medicine Research Program of the United States Army Medical Research and Development Command.
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Lykova, Inna, Ralph Rowe, Glenn Poirier, Henrik Friis, and Kate Helwig. "Mckelveyite group minerals – Part 4: Alicewilsonite-(YLa), Na2Sr2YLa(CO3)6 ⋅ 3H2O, a new lanthanum-dominant species from the Paratoo mine, Australia." European Journal of Mineralogy 36, no. 2 (March 22, 2024): 301–10. http://dx.doi.org/10.5194/ejm-36-301-2024.

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Abstract. The new mckelveyite group mineral, alicewilsonite-(YLa), Na2Sr2YLa(CO3)6 ⋅ 3H2O, was found together with kamphaugite-(Y), paratooite-(Y), bastnäsite-(La), and decrespignyite-(Y) coating along fractures in dolomite at the Paratoo copper mine, South Australia, Australia. It occurs as pale pink to colourless pseudohexagonal tabular crystals up to 150 µm in size. The streak is white; the lustre is vitreous. The mineral has no cleavage. Dcalc is 3.37 g cm−3. Alicewilsonite-(YLa) is optically biaxial (−), α = 1.556(2), β= 1.582(2), γ= 1.592(2), 2V (meas.) = 60(2)°, 2V (calc.) = 63° (589 nm). The IR spectrum is reported. The composition (wt %, average of seven analyses) is Na2O 7.43, CaO 2.00, SrO 18.43, BaO 1.64, Y2O3 9.59, La2O3 11.74, Pr2O3 1.29, Nd2O3 5.74, Sm2O3 0.44, Eu2O3 0.09, Gd2O3 0.95, Dy2O3 1.15, Ho2O3 0.25, Er2O3 0.89, Yb2O3 0.29, CO2 29.78, H2O 6.18, total 97.88. The empirical formula calculated on the basis of six cations with 3 H2O molecules is as follows: Na2.10Ca0.31Sr1.56Ba0.10Y0.74La0.63Pr0.07 Nd0.30Sm0.03Eu0.01Gd0.04Dy0.05Ho0.01Er0.04 Yb0.01(CO3)5.92(H2O)3. The mineral is triclinic, P1, a= 8.9839(2), b= 8.9728(3), c= 6.7441(2) Å, α= 102.812(2)°, β= 116.424(2)°, γ= 60.128(2)°, and V= 422.17(2) Å3 and Z= 1. The strongest reflections of the powder X-ray diffraction pattern [d,Å(I)(hkl)] are 6.03(43)(001), 4.355(100)(11‾0, 2‾1‾1, 120), 4.020(30)(1‾11, 210, 1‾2‾1), 3.188(29)(2‾1‾2, 11‾1, 121), 2.819(96)(002, 1‾12, 211, 1‾2‾2), 2.592(40)(3‾01, 030, 3‾3‾1), 2.228(33)(2‾21, 4‾2‾1, 2‾4‾1). 2.011(36)(2‾22, 003, 420, 2‾4‾2), 1.9671(32)(3‾03, 301, 03‾2, 032, 3‾3‾3, 331). The crystal structure was solved and refined from single-crystal X-ray diffraction data (R1= 0.058).
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Saghir, Sultan A. M., Amer A. Almaiman, Aishah K. A. Shatar, Norris Naim, and Huda S. Baqir. "HemoCue against Coulter LH-750 in the estimation of hemoglobin levels of blood donors in mobile collection settings: a comparative study." Medical Journal of Indonesia 27, no. 4 (December 31, 2018): 250–5. http://dx.doi.org/10.13181/mji.v27i4.2635.

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Background: The fast and outpatient setting for a determination of the hemoglobin (Hb) level is a well-recognized prerequisite to detect anemia in blood donors. This study aimed to evaluate the performance of the HemoCue methods (HemoCue B-Hb and HemoCue-301) against Coulter LH-750 as a reference method for Hb determination.Methods: This study was an experimental cross-sectional study. It includes 455 blood samples that were collected from volunteer blood donors between January 15, 2010 and February 15, 2011. The performance of the three methods and their comparisons were assessed using the analysis of coefficients of variation (CV), linear regression, and mean difference. Correlation coefficient and Bland–Altman plots were drawn to compare the two HemoCue measurements and the automated cell analyzer against each other and to evaluate their results. The Hb concentrations were compared using the concordance correlation coefficient.Results: The findings exhibited that the CV for the three methods Coulter LH-750, HemoCue B-Hb, and HemoCue-301 were 0.60%, 0.72%, and 0.92%, respectively. A statistically significant difference was observed between the means of the Hb measurements for the three methods (p<0.001). The HemoCue B-Hb and HemoCue-301 methods showed the best agreement, and the Coulter LH-750 method gave a lower Hb value compared with the two HemoCue methods. The results showed a positive correlation of HemoCue Hb results compared with the reference method.Conclusion: All three methods provide a good agreement for Hb determination. The new device HemoCue-301 was found to be more accurate compared with HemoCue B-Hb and Coulter LH-750.
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McKinley, Lauren E., Sabrina Hua, Julia Stal, Maya S. D'Eon, Niloofar Afari, and Terry A. Cronan. "Predictors of Quality of Life Among Breast Cancer Patients." Californian Journal of Health Promotion 19, no. 1 (September 8, 2021): 1–12. http://dx.doi.org/10.32398/cjhp.v19i1.2642.

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Over 3.1 million women living in the U.S. have been diagnosed with breast cancer. The purpose of the present study was to determine whether stage of cancer, psychological distress, cognitive fusion (fusion of one’s thoughts and emotions), mindfulness, and resilience were related to quality of life among breast cancer patients. Participants were 24 women, aged 41-71, diagnosed with stage 0-3 breast cancer, recruited to participate in a pilot intervention study. All data for this study were collected at the baseline assessment. A multiple linear regression analysis explained 79.1% of the total variance in quality of life, F(5, 14) = 15.400, p < .001, Adjusted R2 = .791. Higher resilience significantly predicted higher quality of life (b = 2.392, p = .002), whereas higher stage of cancer (b = -8.068, p = .030) and higher levels of psychological distress (b = -1.737, p < .001) significantly predicted lower quality of life. Contrary to the hypotheses, higher levels of mindfulness significantly predicted lower quality of life (b = -0.612, p = .022). Cognitive fusion did not significantly predict quality of life (p > .05). More research is needed to determine how various factors predict quality of life among breast cancer patients.
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Shaw, Gregory, Gary Slater, and Louise M. Burke. "Changes in the Supplementation Practices of Elite Australian Swimmers Over 11 Years." International Journal of Sport Nutrition and Exercise Metabolism 26, no. 6 (December 2016): 565–71. http://dx.doi.org/10.1123/ijsnem.2016-0060.

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Thirty nine elite Australian swimmers (13 AIS, 26 OTHER) completed a standardized questionnaire regarding their supplement use during a pre competition camp. The data were compared with a similar study conducted 11 years earlier (11 AIS, 23 OTHER) and framed around the classification system of the Sport Supplement Program of the Australian Institute of Sport. The prevalence of supplement use remained constant over time (2009: 97%, 1998: 100%). However, the current swimmers used a greater number of dietary supplements (9.2 ± 3.7 and 5.9 ± 2.9; p = .001), accounted for by an increase in the reported use of supplements with a greater evidence base (Sports Foods, Ergogenics, and Group B supplements). In contrast, fewer supplements considered less reputable (Group C and D) were reported by the 2009 cohort (0.7 ± 1.0 and 1.6 ± 1.3; p = .003). AIS swimmers reported a greater use of Ergogenics (4.3 ± 1.8 and 3.1 ± 1.7; p = .002), and less use of Group C and D supplements overall (0.8 ± 1.2 and 1.3 ± 1.2; p = .012), which was explained primarily by a smaller number of these supplements reported by the 2009 group (1998 AIS: 1.5 ± 1.4, 2009 AIS: 0.2 ± 0.6; p = .004). Although the prevalence of supplement use has not changed over time, there has been a significant increase in the number and type of products they are using. The potential that these changes can be attributed to a Sports Supplement Program merit investigation.
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Abdalla, Marwah, Sumayya Shurovi, Michelle David, Talea Cornelius, Ari Shechter, and Joseph Schwartz. "0912 The Association Between Somatization and Sleep." SLEEP 47, Supplement_1 (April 20, 2024): A391—A392. http://dx.doi.org/10.1093/sleep/zsae067.0912.

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Abstract Introduction Somatization, the experience of having somatic symptoms (e.g., pain, fatigue, dizziness) with resultant psychological distress, has been described among working adults and contributes to work-related absences. Whether somatization affects employees’ sleep quality and sleep duration is unclear. We examined the association of somatization with sleep quality and duration. Methods Data came from the 4th wave of the multi-site Worksite Blood Pressure Study, which assessed psychological factors and ambulatory blood pressure. A total of 472 participants without major cardiovascular disease from 10 worksites in NYC were recruited across 4 waves and ~11 years. At Wave 4, participants completed the Brief Symptom Inventory (BSI) and a sleep questionnaire derived from the Sleep Heart Health Study. Items from the BSI were averaged and T-scored (normed to mean=50, SD=10). Items assessing sleep quality were averaged (higher scores indicated worse sleep quality). Weekday sleep duration was also reported using a one-time sleep diary. Analyses were restricted to participants providing complete data (N= 238). Linear regression models were specified predicting (1) sleep quality and, separately (2) sleep duration from somatization. Covariates were age, sex, race/ethnicity, body mass index, marital status, years of education, family income, employment status, and average work hours per week. Results Of the 238 participants, 79.8% were male, 11.8% were Black, 5.9% were Hispanic/Latinx, and 76.5% were married. Median family income was $70,000-$79,999. Mean age was 52.4 years (SD=8.1), mean years of education was 17.9 (SD=3.1), mean body mass index was 27.9 kg/m2 (SD=3.8), and mean hours worked per week (among those currently employed; n=191) was 42.0 (SD=10.9). Mean somatization score was 49.5 (SD=9.3), mean sleep quality was 8.4 (SD=4.3), and mean sleep duration was 6.5 hours/night (SD=1.1). Higher somatization scores were significantly associated with worse sleep quality, B=0.15, 95% CI 0.09, 0.20, p&lt; 0.001. The association of somatization with sleep duration was not significant, B= 0.01, 95% CI -0.00, 0.02, p=0.18. Conclusion There was an association between somatization and sleep quality but not with sleep duration. Future research should examine whether treatment modalities for somatization among working adults improve sleep quality and overall occupational health. Support (if any) P01HL47540, NIH/NHLBI K23HL141682
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Cosme, Ismael, Andrey Kosarev, Francisco Temoltzi Avila, and Adrian Itzmoyotl. "Comparison of Doping of Gey Si1-y:H (y>0.95) Films Deposited by Low Frequency PECVD at High (300°C) and Low (160°C) Temperatures." MRS Proceedings 1426 (2012): 295–99. http://dx.doi.org/10.1557/opl.2012.865.

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ABSTRACTIn this work we present the results of comparative study n- and p-doping of Ge:H and Ge0.96Si0.04 :H films deposited by LF PECVD at high deposition temperature (HT) Td=300°C and low deposition temperature (LT) Td=160°C. The concentration of boron and phosphorus in solid phase was measured by means of SIMS technique. Such parameters as spectral dependence of absorption coefficient, room temperature conductivity σRT and activation energy Ea for both intrinsic and doped films were obtained. The doping range studied in gas phase was for boron [B]gas= 0 to 0.15% and for phosphorus [P]gas= 0 to 0.2%. In general effect of deposition temperature on P and B doping has been demonstrated. For LT films changes of [P]gas=0.04% to 0.22% resulted in more than 2 orders increasing conductivity and reducing activation energy from Ea=0.28 to 0.16 eV. HT films in the range of [P]gas=0.04% to 0.2% demonstrated saturation of conductivity. HT films showed continuous reducing Ea with increase of [P]gas. In the case of boron doping both HT and LT films had a minimum of conductivity at certain values of [B]gas=0.05% (LT films) and 0.04% (HT films) and related maximums of activation energy Ea(max) at the same doping with Ea(max)=0.47 eV for HT and Ea(max)=0.53 eV for LT films. It suggests a compensation of electron conductivity in un-doped films for low B doping. Further raising [B]gas leads to reducing Ea and the smallest Ea=0.27 eV was obtained at [B]gas=0.18% for HT films and Ea=0.33 eV at [B]gas=0.14% for LH films.
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Books on the topic "301/.092 b"

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1932-2010, Parker Robert B., ed. Robert B. Parker's Fool me twice: A Jesse Stone novel. New York: G. P. Putnam's Sons, 2012.

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HanC, Buechler, and Buechler Judith-Maria, eds. The world of Sofía Velasquez: The autobiography of a Bolivian market vendor. New York: Columbia University Press, 1996.

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1943-, Wilkinson Richard G., Marmot M. G, and World Health Organization. Regional Office for Europe., eds. Social determinants of health: The solid facts. 2nd ed. Copenhagen: WHO Regional Office for Europe, 2003.

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Plutarch. Life of Antony. Cambridge: Cambridge University Press, 1988.

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Harriet Martineau, first woman sociologist. Oxford [England]: Berg, 1992.

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Pierre Bourdieu: Agent Provocateur. Bloomsbury Publishing Plc, 2004.

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Pierre Bourdieu: Agent Provocateur. Bloomsbury Publishing Plc, 2004.

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Patrick Geddes: Social evolutionist and city planner. London: Routledge, 1993.

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Patrick Geddes: Social evolutionist and city planner. London: Routledge, 1990.

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Barnett, Mac, and Mike Lowery. Mac Undercover (Mac B. , Kid Spy #1). Scholastic, Incorporated, 2018.

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Conference papers on the topic "301/.092 b"

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Fox, A. M., David A. B. Miller, J. E. Cunningham, J. E. Henry, W. Y. Jan, and G. Livescu. "Excitonic saturation intensity in GaAs/AlGaAs quantum well optical modulators." In OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1989. http://dx.doi.org/10.1364/oam.1989.mb2.

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Exciton saturation adversely limits the switching speed of GaAs/AlxGa1-xAs quantum well electroabsorptive optical modulators. We have studied the dependence of the exciton saturation intensity Isx on the strength of the applied field and the height and width of the AlGaAs barriers. Five PIN photodiodes were grown by molecular beam epitaxy with the quantum wells comprising the intrinsic region. The well width was kept nominally constant, but x ranged from 0.2 to 0.4 and the barrier thickness L b varied between 31 and 95 Å. We found that Isx increases with applied field, and also depends strongly on x and Lb.For L b = 65 Å at zero applied field, Isx increased from 1.3 to 43 kW cm−2 on reducing x from 0.4 to 0.2. Similarly, for x = 0.3 at zero bias, Isx increased from 3.1 to 18 kW cm−2 on reducing Lb from 95 to 31 Å. These results can be explained in terms of a reduction of the carrier lifetime caused by barrier and field dependent tunneling rates. The field dependence of the carrier escape time for the sample with x = 0.31 and Lb = 31 Å was measured by the time-resolved electroabsorption technique.1,2 The measured escape time is ~100 ps at fields below 30 kV cm−1 and decreases to ~10 ps at fields above 60 kV cm−1.
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Jiang, Jing, Christopher J. Kirk, and Tony Muchamuel. "Abstract 4796: Carfilzomib and ONX 0912 reduce the level of STAT3 phosphorylation in human B-cell lymphoma cells in vitro and in vivo." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4796.

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Randi, A. M., E. Sacchi, and M. Cattaneo. "ORALLY ADMINISTERED VITAMIN B PROLONGS THE BLEEDING TIME AND INHIBITS PLATELET AGGREGATION IN HUMAN VOLUNTEERS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643446.

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It is known that mM concentrations of vitamin B6 inhibit human platelet aggregation and fibrin formation in vitro. There are very few and controversial data on the ex vivo effects of vitamin B6 on hemostatic parameters. We evaluated the effects of oral administration of vitamin B6 on bleeding time (BT), fibrin formation, platelet aggregation (PA) and the release reaction (RR). Vitamin B6 300 mg/day p.o., was given to 18 healthy volunteers (8 M, 10 F, aged 23-35) for 8 days. BT was measured before the first dose (Baseline), 2 hr after the first (Day 1) and the last dose (Day 8). In 7 subjects BT was measured also 7 days after the suspension of the drug (Day 15). Before and 2 hr after the first dose, prothrombin time (PT), partial thromboplastin time (PTT), thrombin time (TT), PA and the RR induced by different concentrations of ADP, PAF-acether, collagen (coll), epinephrine (epi), arachidonate (AA) were studied. BT was significantly prolonged after vitamin B6 administration, and returned to baseline values 7 days after suspension of the drug. PA and the RR induced by 1 uM ADP, 1 ug/ml coll or 5 uM epi were significantly inhibited 2 hours after vitamin B6 administration. Vitamin B6, however, did not affect PA or the RR induced by 0.2-2 uM PAF-acether, 2 uM ADP, 1 mM AA, 2 ug/ml coll, nor did it affect PT, PTT or TT. These data show that orally administered vitamin B impairs primary hemostasis, but does not affect fibrin 6 formation, as measured with standard coagulation tests.
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4

Cheng, Kun, Jian Deng, Rong Cai, Libo Qian, Peiyao Qi, and Bingzheng Ke. "Study on Natural Circulation Flow Instabilities in Rod Bundle Channel Under Rolling Condition." In 2020 International Conference on Nuclear Engineering collocated with the ASME 2020 Power Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/icone2020-16362.

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Abstract The effects of rolling condition on the flow instability characteristics of natural circulation (NC) in rod bundle channel were experimentally studied. A 3 × 3 rod bundle channel is used as the testing section. The experimental system pressure range is 0.2 to 0.6 MPa, and the range of inlet subcooling is 10 to 70 °C. The ranges of rolling motion amplitude and period are 10 ∼ 20° and 10 ∼ 30s, respectively. Two typical two-phase flow instabilities in rod bundle channel under rolling condition were found in experiments: (a) the trough-type oscillation caused by the vapor generation at the minimum point of flow fluctuation and (b) the compound oscillation formed by the superposition of the trough-type oscillation and DWOI. Experimental results show that the rolling motion can reduce the threshold heating power of trough-type oscillation and cause the occurrence of NC flow instability in advance. But the rolling motion cannot affect the dimensionless boundary of DWOI in rod bundle channel.
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5

Kent, R. "CORONARY THROMBOLYSIS AND PREVENTION OF RE0CCLUSI0N WITH RECOMBINANT DOUBLECHAIN TISSUE PLASMINOGENACTIVATOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643744.

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The dose response (DR) of tissue plasminogen activator (t-PA) in patients (pts) with acutemyocardial infarction (AMI) and the efficacy of 4-6 hr maintenance infusions (M) of t-PA in preventing early reocclusion (R) have been reported in small numbers of pts. No studies have determined the efficacy of longer M in limiting short term R.In two related trials weexamined DR and long term M in a large numberof pts. We administered a uniform t-PA product [>98% double chain (DC)] to 223 pts 3.1 ±1.1 hrs after the onset of AMI.Pts received 0.25 - 0.95 megaunits (MU)/kg/90min and then underwent coronary angiography(CA):Responders were defined by TIMI grades 2 or 3. Results were In a logistic regression anaylsis the coefficient for dose was significant(p<.02). Two subsets of the above pts received M. Groups A (4l pts) and B (51 pts) had received 0.26 - 0.40 and 0.4l - 0.54 MU/kg/90 min respectively. 66% of A and 78%of B were responders, received an additional 90 minof t-PA at 1/3 the initial rate and then 1 of4 M for 9-21 hrs (mean total 17.2±4.5 hrs) at which time CA was repeated. Results for A + B were:For all pts fibrinogen decreases were mild. Bleeding was primarily related to vascular invasion and M length. We conclude that the DR for DC tPA can be accurately defined and long term M to limit .short term R are feasible. Future studies may define t-PA dosing regimens suited for specific clinical situations.
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6

Wallin, R., and T. Saldeen. "DEVELOPMENT OF A SPECIFIC RADIODMMUNOASSAY FOR DETERMINATION OF PEPTIDES DERIVED FROM HUMAN LEUKOCYTE ELASTASE DEGRADATION OF HUMAN FIBRIN (OGEN)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643899.

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This paper describes a RIA for determination of the vasoactive peptide BB 30-43 and related peptides derived from leukocyte elastase degradaticn of human fibrin(ogen). The peptide was synthesized and could easily be labelled with 125I.Rabbits were iirmunized with BB 30-43 conjugated to bovine albumin. The antibody was found to bind about 5C% of the tracer in absence of BB 30-43 in a ˜1/800 diluticn. The RIA can detect peptide concentrations between 50 - 25000 pmol/L. The crossreaction with fibrinogen is very low (<0.001%) and with plas-min derived fibrin(ogen) peptides Bβ 1-42 and BB 15-42 also low (<0.2%). Plasma samples can be analyzed without any pretreatment. In an in vitro study fibrin and fibrincgen was degraded with plasmin or leukocyte elastase. Plasmin degradaticn of fibrin and fibrincgen did not release peptides which cross-reacted with our antibody, whereas leukocyte elastase degradation released peptides from both fibrin and fibrinogen which crossreact whith the antibody.The imnunolqgical activity was not changed after degrading peptide Bβ 30-43 with a) trypsin, b) plasmin, c) batraxobin, d) thrombin, e) elastase, at +37°,1 h, in a molar ratio of 1:100. Even degradaticn by elastase (1:3.5) +37°, 1 h, did not destroy the iirmunological activity.The imriunolcgical stability of peptide B< 30-43 in EDTA-plasma (+37°) seems to be very good. In citrated and heparinized plasma the activity of this peptide seems to vanish quite fast. In spite of these results we have detected high levels of iirmunolcgical activitiy in citrated or heparinized patient plasma. The molecular distribution of the peptides detected in plasma by our RIA corresponded to a fragnent containing about 25 amino acids. This fragnent seemes to be rather stable in plasma. When this fragnent was degraded with elastase in vitro a peptide with a molecular size resembling BB 30-43 was obtained. Over 300 patient samples have been studied. About 20 per cent were positive and the highest levels were found in patients with ARDS, septicaemia, severe renal failure, pulmonary embolism, pneumonia and pulmonary congestion.
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