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Journal articles on the topic '3-disubstituted oxindoles'

Author: Grafiati

Published: 6 September 2023

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1

Ortega-Martínez, Aitor, Cynthia Molina, Cristina Moreno-Cabrerizo, José Sansano, and Carmen Nájera. "Synthesis of 3,3-Disubstituted 2-Oxindoles by Deacylative Alkylation of 3-Acetyl-2-oxindoles." Synthesis 49, no. 23 (August 22, 2017): 5203–10. http://dx.doi.org/10.1055/s-0036-1590880.

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An innovative and efficient monoalkylation and nonsymmetrical 3,3-dialkylation of oxindoles has been achieved. First, the monoalkylation of 3-acetyl-2-oxindoles can be performed in good yields under mild reaction conditions using alkyl halides and benzyltrimethylammonium hydroxide (Triton B) as base at room temperature. This methodology is applied to construct the synthetically challenging compound 1,3-dimethyl-2-oxindole. Subsequent deacylative alkylation (DaA) of the alkylated 3-acetyl-2-oxindoles with alkyl halides takes place efficiently using LiOEt or by conjugate addition with electron-deficient alkenes in the presence of Triton B at room temperature under argon, affording the corresponding unsymmetrically 3,3-disubstituted 2-oxindoles. This simple methodology has been applied to the synthesis of precursors of horsfiline, esermethole, physostigmine, and phenserine alkaloids.

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2

Cui, Bao-Dong, Yong You, Jian-Qiang Zhao, Jian Zuo, Zhi-Jun Wu, Xiao-Ying Xu, Xiao-Mei Zhang, and Wei-Cheng Yuan. "3-Pyrrolyl-oxindoles as efficient nucleophiles for organocatalytic asymmetric synthesis of structurally diverse 3,3′-disubstituted oxindole derivatives." Chemical Communications 51, no. 4 (2015): 757–60. http://dx.doi.org/10.1039/c4cc08364d.

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3

Ding, Zhengtian, and Wangqing Kong. "Synthesis of Carbonyl-Containing Oxindoles via Ni-Catalyzed Reductive Aryl-Acylation and Aryl-Esterification of Alkenes." Molecules 27, no. 18 (September 11, 2022): 5899. http://dx.doi.org/10.3390/molecules27185899.

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Carbonyl-containing oxindoles are ubiquitous core structures present in many biologically active natural products and pharmaceutical molecules. Nickel-catalyzed reductive aryl-acylation of alkenes using aryl anhydrides or alkanoyl chlorides as acyl sources is developed, providing 3,3-disubstituted oxindoles bearing ketone functionality at the 3-position. Moreover, nickel-catalyzed reductive aryl-esterification of alkenes using chloroformate as ester sources is further developed, affording 3,3-disubstituted oxindoles bearing ester functionality at the 3-position. This strategy has the advantages of good yields and high functional group compatibility.

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4

Chen, Lin, Yong You, Ming-Liang Zhang, Jian-qiang Zhao, Jian Zuo, Xiao-Mei Zhang, Wei-Cheng Yuan, and Xiao-Ying Xu. "Organocatalytic asymmetric Michael addition of 3-substituted oxindoles to α,β-unsaturated acyl phosphonates for the synthesis of 3,3′-disubstituted oxindoles with chiral squaramides." Organic & Biomolecular Chemistry 13, no. 15 (2015): 4413–17. http://dx.doi.org/10.1039/c5ob00317b.

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5

Cheng, Wen-Fu, Ling-Yan Chen, Fang-Fang Xu, Wei-Yu Lin, Xinfeng Ren, and Ya Li. "Organocatalytic asymmetric Michael addition between 3-subsituted oxindoles and enals catalyzed by camphor sulfonyl hydrazine." Organic & Biomolecular Chemistry 17, no. 4 (2019): 885–91. http://dx.doi.org/10.1039/c8ob02934b.

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3,3-Disubstituted oxindoles containing vicinal stereogenic carbon centers have been synthesized through organocatalytic asymmetric Michael addition between 3-substituted oxindoles and enals catalyzed by chiral camphor sulfonyl hydrazines (CaSHs).

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6

Rao, Madhuri P., Shubha S. Gunaga, Johannes Zuegg, Rambabu Pamarthi, and Madhu Ganesh. "Highly regio- and diastereoselective [3 + 2]-cycloadditions involving indolediones and α,β-disubstituted nitroethylenes." Organic & Biomolecular Chemistry 17, no. 42 (2019): 9390–402. http://dx.doi.org/10.1039/c9ob01429b.

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7

Zhang, Chun-Lin, You-Feng Han, and Song Ye. "N-Heterocyclic carbene-catalyzed β-addition of enals to 3-alkylenyloxindoles: synthesis of oxindoles with all-carbon quaternary stereocenters." Chemical Communications 55, no. 55 (2019): 7966–69. http://dx.doi.org/10.1039/c9cc03099a.

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8

Krishnan, Shyam, and Brian M. Stoltz. "Preparation of 3,3-disubstituted oxindoles by addition of malonates to 3-halo-3-oxindoles." Tetrahedron Letters 48, no. 43 (October 2007): 7571–73. http://dx.doi.org/10.1016/j.tetlet.2007.08.131.

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9

Li, Man, Fu-Sheng He, Long-Shan Ji, Ya-Ting Gao, Xin Zhang, Zhuo Yu, Miao Fang, Jie Wu, and Yue-Qiu Gao. "Synthesis and biological evaluation of fluorinated 3,4-dihydroquinolin-2(1H)-ones and 2-oxindoles for anti-hepatic fibrosis." RSC Advances 11, no. 11 (2021): 5923–27. http://dx.doi.org/10.1039/d0ra09430g.

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10

Cao, An-Zhu, Yu-Ting Xiao, Yan-Chen Wu, Ren-Jie Song, Ye-Xiang Xie, and Jin-Heng Li. "Copper-catalyzed C–H [3 + 2] annulation of N-substituted anilines with α-carbonyl alkyl bromides via C(sp3)–Br/C(sp2)–H functionalization." Organic & Biomolecular Chemistry 18, no. 11 (2020): 2170–74. http://dx.doi.org/10.1039/d0ob00399a.

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11

Xu, Lubin, Haohua Chen, Jian Liu, Lan Zhou, Qing Liu, Yu Lan, and Jian Xiao. "Chiral phosphoric acid-catalyzed asymmetric C(sp3)–H functionalization of biomass-derived 2,5-dimethylfuran via two sequential Cope-type rearrangements." Organic Chemistry Frontiers 6, no. 8 (2019): 1162–67. http://dx.doi.org/10.1039/c8qo01375f.

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The first organocatalytic asymmetric C(sp³)–H functionalization of biomass-derived 2,5-dimethylfuran with alcohols to afford enantioenriched furan-derived 3,3′-disubstituted oxindoles in high enantioselectivity.

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12

Liu, Yong-Liang, Xiao-Ping Wang, Jie Wei, and Ya Li. "Synthesis of oxindoles bearing a stereogenic 3-fluorinated carbon center from 3-fluorooxindoles." Organic & Biomolecular Chemistry 20, no. 3 (2022): 538–52. http://dx.doi.org/10.1039/d1ob01964c.

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13

Wang, Juanjuan, Danfeng Huang, Ke-Hu Wang, Xiansha Peng, Yingpeng Su, Yulai Hu, and Ying Fu. "Tin powder-promoted one-pot synthesis of 3-spiro-fused or 3,3′-disubstituted 2-oxindoles." Organic & Biomolecular Chemistry 14, no. 40 (2016): 9533–42. http://dx.doi.org/10.1039/c6ob01487a.

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A convenient and efficient method for the constructions of 3-spirooxindole derivatives or 3,3′-disubstituted oxindoles has been developed from one-pot reactions of isatins, hydrazides or aromatic amines, 2-(bromomethyl)acrylic ester in the presence of a catalytic amount of Brønsted or Lewis acid promoted by tin powder instead of toxic stannanes.

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14

Nakazaki, Atsuo, Keitaro Miyagawa, and Toshio Nishikawa. "Diastereoselective Synthesis of 3,3-Disubstituted Oxindoles from N-Aryl-3-Chlorooxindoles Bearing C–N Axial Chirality via Nucleophilic Substitution." Synlett 26, no. 08 (February 24, 2015): 1116–20. http://dx.doi.org/10.1055/s-0034-1380266.

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Diastereoselective synthesis of 3,3-disubstituted oxindoles was examined using racemic N-aryl-3-chlorooxindoles bearing C–N axial chirality. The reaction involved the nucleophilic substitution of 3-chlorooxindoles via an ortho-azaxylylene intermediate in the presence of AgBF4 and MS 4 Å. High diastereoselectivities (up to >95:<5) were achieved in the formation of 3-alkyl-3-aryloxindole derivatives when electron-rich arenes were used.

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15

Devi, Manju, Amol P. Jadhav, and Ravi P. Singh. "KOH-mediated stereoselective alkylation of 3-bromooxindoles for the synthesis of 3,3′-disubstituted oxindoles with two contiguous all carbon quaternary centres." New Journal of Chemistry 45, no. 19 (2021): 8445–48. http://dx.doi.org/10.1039/d0nj06283a.

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16

Deng, Fei, Shin A. Moteki, and Keiji Maruoka. "Catalytic Asymmetric Alkylation of 3-Aryl-Substituted Oxindoles to give 3,3-Disubstituted Oxindoles under Phase-Transfer Conditions." Asian Journal of Organic Chemistry 3, no. 4 (March 12, 2014): 395–98. http://dx.doi.org/10.1002/ajoc.201400011.

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17

Feng, Ting-Ting, Xuan Huang, Xiong-Li Liu, De-Hong Jing, Xiong-Wei Liu, Feng-Ming Guo, Ying Zhou, and Wei-Cheng Yuan. "Highly regioselective synthesis of 3-alkenyl-oxindole ring-fused 3,3′-disubstituted oxindoles via direct gamma-substitution of Morita–Baylis–Hillman carbonates of isatins with 3-substituted oxindoles." Org. Biomol. Chem. 12, no. 46 (October 2, 2014): 9366–74. http://dx.doi.org/10.1039/c4ob01523a.

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18

Meerakrishna, Ramakrishnan Suseela, Suresh Snoxma Smile, Mohanakumaran Athira, Venkata Surya Kumar Choutipalli, and Ponnusamy Shanmugam. "Diverse reactivity of isatin-based N,N′-cyclic azomethine imine dipoles with arynes: synthesis of 1′-methyl-2′-oxospiro [indene-1,3′-indolines] and 3-aryl-3-pyrazol-2-oxindoles." New Journal of Chemistry 44, no. 27 (2020): 11593–601. http://dx.doi.org/10.1039/d0nj01684e.

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Reaction of aryne with isatin based N,N′-cyclic AMI 1,3-dipole afforded 3,3-disubstituted oxindole while methyl substitution on the pyrrolidine ring of 1,3-dipole directed [3+2] cycloaddition products.

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19

Deng, Fei, Shin A. Moteki, and Keiji Maruoka. "ChemInform Abstract: Catalytic Asymmetric Alkylation of 3-Aryl-Substituted Oxindoles to Give 3,3-Disubstituted Oxindoles under Phase-Transfer Conditions." ChemInform 45, no. 45 (October 23, 2014): no. http://dx.doi.org/10.1002/chin.201445125.

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20

Cui, Bao-Dong, Yong You, Jian-Qiang Zhao, Jian Zuo, Zhi-Jun Wu, Xiao-Ying Xu, Xiao-Mei Zhang, and Wei-Cheng Yuan. "ChemInform Abstract: 3-Pyrrolyl-Oxindoles as Efficient Nucleophiles for Organocatalytic Asymmetric Synthesis of Structurally Diverse 3,3′-Disubstituted Oxindole Derivatives." ChemInform 46, no. 23 (May 22, 2015): no. http://dx.doi.org/10.1002/chin.201523124.

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21

Zuo, Jian, Zhi-Jun Wu, Jian-Qiang Zhao, Ming-Qiang Zhou, Xiao-Ying Xu, Xiao-Mei Zhang, and Wei-Cheng Yuan. "Preparation of 3-Sulfonylated 3,3-Disubstituted Oxindoles by the Addition of Sulfinate Salts to 3-Halooxindoles." Journal of Organic Chemistry 80, no. 1 (December 8, 2014): 634–40. http://dx.doi.org/10.1021/jo502270a.

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22

Song, Xiang-Jia, Hong-Xia Ren, Min Xiang, Chen-Yi Li, Ying Zou, Xia Li, Zhi-Cheng Huang, Fang Tian, and Li-Xin Wang. "Organocatalytic Enantioselective Michael Addition between 3-(3-hydroxy-1H-pyrazol-1-yl)Oxindole and β-Nitrostyrene for the Preparation of Chiral Disubstituted Oxindoles." Journal of Organic Chemistry 85, no. 14 (June 25, 2020): 9290–300. http://dx.doi.org/10.1021/acs.joc.9b03337.

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23

Kaur, Jasneet, Anita Kumari, and Swapandeep Singh Chimni. "Grinding assisted, column chromatography free decarboxylative carbon-carbon bond formation: Greener synthesis of 3, 3-disubstituted oxindoles." Tetrahedron 73, no. 6 (February 2017): 802–8. http://dx.doi.org/10.1016/j.tet.2016.12.070.

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24

Lee, Hyun Ju, Ko Hoon Kim, Se Hee Kim, and Jae Nyoung Kim. "Palladium-catalyzed oxidative arylation of trisubstituted olefin: an efficient synthesis of 3-(disubstituted)alkylidene-oxindoles." Tetrahedron Letters 54, no. 2 (January 2013): 170–75. http://dx.doi.org/10.1016/j.tetlet.2012.10.122.

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25

Jia, Shi-Kun, Long-Long Song, Yu-Bing Lei, A. Gopi Krishna Reddy, Dong Xing, and Wen-Hao Hu. "A Rh(ii)-catalyzed three-component reaction of 3-diazooxindoles with N,N-disubstituted anilines and glyoxylates for the synthesis of 3-aryl-3-substituted oxindoles." Organic & Biomolecular Chemistry 14, no. 43 (2016): 10157–60. http://dx.doi.org/10.1039/c6ob01907b.

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26

Zuo, Jian, Zhi-Jun Wu, Jian-Qiang Zhao, Ming-Qiang Zhou, Xiao-Ying Xu, Xiao-Mei Zhang, and Wei-Cheng Yuan. "ChemInform Abstract: Preparation of 3-Sulfonylated 3,3-Disubstituted Oxindoles by the Addition of Sulfinate Salts to 3-Halooxindoles." ChemInform 46, no. 22 (May 15, 2015): no. http://dx.doi.org/10.1002/chin.201522152.

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27

You, Yong, Zhi-Jun Wu, Zhen-Hua Wang, Xiao-Ying Xu, Xiao-Mei Zhang, and Wei-Cheng Yuan. "Enantioselective Synthesis of 3,3-Disubstituted Oxindoles Bearing Two Different Heteroatoms at the C3 Position by Organocatalyzed Sulfenylation and Selenenylation of 3-Pyrrolyl-oxindoles." Journal of Organic Chemistry 80, no. 16 (August 12, 2015): 8470–77. http://dx.doi.org/10.1021/acs.joc.5b01491.

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28

Wu, Chongyang, Guofeng Li, Wangsheng Sun, Ming Zhang, Liang Hong, and Rui Wang. "Organocatalytic Highly Enantioselective Monofluoroalkylation of 3-Bromooxindoles: Construction of Fluorinated 3,3′-Disubstituted Oxindoles and Their Derivatives." Organic Letters 16, no. 7 (March 18, 2014): 1960–63. http://dx.doi.org/10.1021/ol500517d.

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29

Kim, Ko Hoon, Hye Ran Moon, Junseong Lee, and Jae Nyoung Kim. "Palladium-Catalyzed Construction of Spirooxindoles by Arylative Cyclization of 3-(γ,δ-Disubstituted)allylidene-2-Oxindoles." Advanced Synthesis & Catalysis 357, no. 4 (February 4, 2015): 701–8. http://dx.doi.org/10.1002/adsc.201400965.

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30

Lee, Hyun Ju, Ko Hoon Kim, Se Hee Kim, and Jae Nyoung Kim. "ChemInform Abstract: Palladium-Catalyzed Oxidative Arylation of Trisubstituted Olefin: An Efficient Synthesis of 3-(Disubstituted)alkylidene-oxindoles." ChemInform 44, no. 15 (March 25, 2013): no. http://dx.doi.org/10.1002/chin.201315107.

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31

Kókai, Eszter, Gyula Simig, and Balázs Volk. "Literature Survey and Further Studies on the 3-Alkylation of N-Unprotected 3-Monosubstituted Oxindoles. Practical Synthesis of N-Unprotected 3,3-Disubstituted Oxindoles and Subsequent Transformations on the Aromatic Ring." Molecules 22, no. 1 (December 26, 2016): 24. http://dx.doi.org/10.3390/molecules22010024.

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32

Chen, Lin, Yong You, Ming-Liang Zhang, Jian-qiang Zhao, Jian Zuo, Xiao-Mei Zhang, Wei-Cheng Yuan, and Xiao-Ying Xu. "ChemInform Abstract: Organocatalytic Asymmetric Michael Addition of 3-Substituted Oxindoles to α,β-Unsaturated Acyl Phosphonates for the Synthesis of 3,3′-Disubstituted Oxindoles with Chiral Squaramides." ChemInform 46, no. 34 (August 2015): no. http://dx.doi.org/10.1002/chin.201534147.

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33

Pathan, Mohsinkhan Y., Santosh S. Chavan, Taufeekaslam M. Y. Shaikh, Shridhar H. Thorat, Rajesh G. Gonnade, and Shafeek A. R. Mulla. "Facile One-Pot Multi-Component Synthesis of Spirooxindoles and 3, 3’-Disubstituted Oxindoles via sp3 C-H Activation/Functionalization of Azaarenes." ChemistrySelect 2, no. 28 (September 29, 2017): 9147–52. http://dx.doi.org/10.1002/slct.201701507.

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34

Zuo, Jian, Yu-Hua Liao, Xiao-Mei Zhang, and Wei-Cheng Yuan. "Organocatalyzed Enantioselective Decarboxylative Stereoablation Reaction for the Construction of 3,3′-Disubstituted Oxindoles Using β-Ketoacids and 3-Halooxindoles." Journal of Organic Chemistry 77, no. 24 (December 7, 2012): 11325–32. http://dx.doi.org/10.1021/jo302048v.

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35

Kim, Ko Hoon, Hye Ran Moon, Junseong Lee, and Jae Nyoung Kim. "ChemInform Abstract: Palladium-Catalyzed Construction of Spirooxindoles by Arylative Cyclization of 3-(γ,δ-Disubstituted)allylidene-2-Oxindoles." ChemInform 46, no. 31 (July 16, 2015): no. http://dx.doi.org/10.1002/chin.201531140.

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36

Wu, Chongyang, Guofeng Li, Wangsheng Sun, Ming Zhang, Liang Hong, and Rui Wang. "ChemInform Abstract: Organocatalytic Highly Enantioselective Monofluoroalkylation of 3-Bromooxindoles: Construction of Fluorinated 3,3′-Disubstituted Oxindoles and Their Derivatives." ChemInform 45, no. 37 (August 28, 2014): no. http://dx.doi.org/10.1002/chin.201437132.

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37

Liu, Xiong-Wei, Zhen Yao, Guan-Lian Wang, Zhi-Yong Chen, Xiong-Li Liu, Min-Yi Tian, Qi-Di Wei, Ying Zhou, and Jian-Fei Zhang. "Efficient 1,6-addition reactions of 3-substituted oxindoles: Access to isoxazole-fused 3,3′-disubstituted oxindole scaffolds and hexahydro-1h-pyrido[2,3-b]indol-2-one scaffolds." Synthetic Communications 48, no. 12 (May 23, 2018): 1454–64. http://dx.doi.org/10.1080/00397911.2018.1454475.

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38

Zhou, Rong, Rongfang Liu, Kai Zhang, Ling Han, Honghui Zhang, Wenchao Gao, and Ruifeng Li. "Metal-free formal carbon–halogen bond insertion: facile syntheses of 3-halo 3,3′-disubstituted oxindoles and spirooxindole-γ-butyrolactones." Chemical Communications 53, no. 51 (2017): 6860–63. http://dx.doi.org/10.1039/c7cc03765a.

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39

Moon, Hye Ran, Ko Hoon Kim, Junseong Lee, and Jae Nyoung Kim. "Synthesis of 3-(γ,δ-Disubstituted)allylidene-2-Oxindoles from Isatins by Wittig Reaction with Morita-Baylis-Hillman Bromides." Bulletin of the Korean Chemical Society 36, no. 1 (January 2015): 219–25. http://dx.doi.org/10.1002/bkcs.10053.

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40

Ohmatsu, Kohsuke, Yuichiro Ando, and Takashi Ooi. "Asymmetric Substitution at the Tetrasubstituted Chiral Carbon: Catalytic Ring-Opening Alkylation of Racemic 2,2-Disubstituted Aziridines with 3-Substituted Oxindoles." Journal of the American Chemical Society 135, no. 50 (December 10, 2013): 18706–9. http://dx.doi.org/10.1021/ja411647x.

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41

Wang, Dong-Chao, Hai-Xia Wang, Er-Jun Hao, Xiao-Han Jiang, Ming-Sheng Xie, Gui-Rong Qu, and Hai-Ming Guo. "Synthesis of 3,3-Disubstituted Oxindoles Containing a 3-(4-Aminobut-2-ynyl) Unit via Domino Heck-Sonogashira Reaction in Water." Advanced Synthesis & Catalysis 358, no. 3 (January 18, 2016): 494–99. http://dx.doi.org/10.1002/adsc.201500887.

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42

Zuo, Jian, Yu-Hua Liao, Xiao-Mei Zhang, and Wei-Cheng Yuan. "ChemInform Abstract: Organocatalyzed Enantioselective Decarboxylative Stereoablation Reaction for the Construction of 3,3′-Disubstituted Oxindoles Using β-Ketoacids and 3-Halooxindoles." ChemInform 44, no. 22 (May 13, 2013): no. http://dx.doi.org/10.1002/chin.201322114.

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43

You, Yong, Zhi-Jun Wu, Jian-Feng Chen, Zhen-Hua Wang, Xiao-Ying Xu, Xiao-Mei Zhang, and Wei-Cheng Yuan. "Organocatalytic Asymmetric Michael Addition of 3-Pyrrolyloxindoles to β-Phthalimidonitroethene for the Synthesis of 3,3′-Disubstituted Oxindoles Bearing Contiguous 3,α,β-Triamino Functionality." Journal of Organic Chemistry 81, no. 13 (June 17, 2016): 5759–65. http://dx.doi.org/10.1021/acs.joc.6b00896.

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44

MORENO-CABRERIZO, CRISTINA, AITOR ORTEGA-MARTÍNEZ, CYNTHIA MOLINA, CARMEN NÁJERA, and JOSÉ M. SANSANO. "Deacylative alkylation (DaA) of N-methyl-3-acetyl-2-oxindole for the synthesis of symmetrically 3,3-disubstituted 2-oxindoles. An access gate to anticancer agents and natural products." Anais da Academia Brasileira de Ciências 90, no. 1 suppl 2 (2018): 1089–99. http://dx.doi.org/10.1590/0001-3765201820170783.

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45

Ohmatsu, Kohsuke, Yuichiro Ando, and Takashi Ooi. "ChemInform Abstract: Asymmetric Substitution at the Tetrasubstituted Chiral Carbon: Catalytic Ring-Opening Alkylation of Racemic 2,2-Disubstituted Aziridines with 3-Substituted Oxindoles." ChemInform 45, no. 27 (June 20, 2014): no. http://dx.doi.org/10.1002/chin.201427114.

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46

Wang, Dong-Chao, Hai-Xia Wang, Er-Jun Hao, Xiao-Han Jiang, Ming-Sheng Xie, Gui-Rong Qu, and Hai-Ming Guo. "Cover Picture: Synthesis of 3,3-Disubstituted Oxindoles Containing a 3-(4-Aminobut-2-ynyl) Unit via Domino Heck-Sonogashira Reaction in Water (Adv. Synth. Catal. 3/2016)." Advanced Synthesis & Catalysis 358, no. 3 (February 2, 2016): 506. http://dx.doi.org/10.1002/adsc.201600052.

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47

Wang, Xiaogang, Jin Zhang, Yuan He, Di Chen, Chao Wang, Fangzhou Yang, Weitao Wang, Yangmin Ma, and Michal Szostak. "Ruthenium(II)-Catalyzed Ortho-C–H Alkylation of Naphthylamines with Diazo Compounds for Synthesis of 2,2-Disubstituted π-Extended 3-Oxindoles in Water." Organic Letters 22, no. 13 (June 19, 2020): 5187–92. http://dx.doi.org/10.1021/acs.orglett.0c01811.

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48

Piemontesi, Cyril, Qian Wang, and Jieping Zhu. "Synthesis of 3,3-disubstituted oxindoles by one-pot integrated Brønsted base-catalyzed trichloroacetimidation of 3-hydroxyoxindoles and Brønsted acid-catalyzed nucleophilic substitution reaction." Organic & Biomolecular Chemistry 11, no. 9 (2013): 1533. http://dx.doi.org/10.1039/c2ob27196f.

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49

Piemontesi, Cyril, Qian Wang, and Jieping Zhu. "ChemInform Abstract: Synthesis of 3,3-Disubstituted Oxindoles by One-Pot Integrated Broensted Base-Catalyzed Trichloroacetimidation of 3-Hydroxyoxindoles and Broensted Acid-Catalyzed Nucleophilic Substitution Reaction." ChemInform 44, no. 29 (July 1, 2013): no. http://dx.doi.org/10.1002/chin.201329113.

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50

Kim, Su Yeon, Sangku Lee, Gieun Kim, Beom Kyu Min, and Jae Nyoung Kim. "Synthesis of 3-(β,δ-Disubstituted)allylidene-2-oxindoles by SN 2′ Reaction of Phosphorous Ylides with Carbonates of Isatin-derived Moritas-Baylis-Hillman Adducts." Bulletin of the Korean Chemical Society 38, no. 9 (July 21, 2017): 1097–100. http://dx.doi.org/10.1002/bkcs.11193.

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