Relevant bibliographies by topics / 3-disubstituted oxindoles

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Academic literature on the topic '3-disubstituted oxindoles'

Author: Grafiati
Published: 6 September 2023

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Journal articles on the topic "3-disubstituted oxindoles"

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Ortega-Martínez, Aitor, Cynthia Molina, Cristina Moreno-Cabrerizo, José Sansano, and Carmen Nájera. "Synthesis of 3,3-Disubstituted 2-Oxindoles by Deacylative Alkylation of 3-Acetyl-2-oxindoles." Synthesis 49, no. 23 (August 22, 2017): 5203–10. http://dx.doi.org/10.1055/s-0036-1590880.

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An innovative and efficient monoalkylation and nonsymmetrical 3,3-dialkylation of oxindoles has been achieved. First, the monoalkylation of 3-acetyl-2-oxindoles can be performed in good yields under mild reaction conditions using alkyl halides and benzyltrimethylammonium hydroxide (Triton B) as base at room temperature. This methodology is applied to construct the synthetically challenging compound 1,3-dimethyl-2-oxindole. Subsequent deacylative alkylation (DaA) of the alkylated 3-acetyl-2-oxindoles with alkyl halides takes place efficiently using LiOEt or by conjugate addition with electron-deficient alkenes in the presence of Triton B at room temperature under argon, affording the corresponding unsymmetrically 3,3-disubstituted 2-oxindoles. This simple methodology has been applied to the synthesis of precursors of horsfiline, esermethole, physostigmine, and phenserine alkaloids.
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2

Cui, Bao-Dong, Yong You, Jian-Qiang Zhao, Jian Zuo, Zhi-Jun Wu, Xiao-Ying Xu, Xiao-Mei Zhang, and Wei-Cheng Yuan. "3-Pyrrolyl-oxindoles as efficient nucleophiles for organocatalytic asymmetric synthesis of structurally diverse 3,3′-disubstituted oxindole derivatives." Chemical Communications 51, no. 4 (2015): 757–60. http://dx.doi.org/10.1039/c4cc08364d.

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3

Ding, Zhengtian, and Wangqing Kong. "Synthesis of Carbonyl-Containing Oxindoles via Ni-Catalyzed Reductive Aryl-Acylation and Aryl-Esterification of Alkenes." Molecules 27, no. 18 (September 11, 2022): 5899. http://dx.doi.org/10.3390/molecules27185899.

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Carbonyl-containing oxindoles are ubiquitous core structures present in many biologically active natural products and pharmaceutical molecules. Nickel-catalyzed reductive aryl-acylation of alkenes using aryl anhydrides or alkanoyl chlorides as acyl sources is developed, providing 3,3-disubstituted oxindoles bearing ketone functionality at the 3-position. Moreover, nickel-catalyzed reductive aryl-esterification of alkenes using chloroformate as ester sources is further developed, affording 3,3-disubstituted oxindoles bearing ester functionality at the 3-position. This strategy has the advantages of good yields and high functional group compatibility.
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Chen, Lin, Yong You, Ming-Liang Zhang, Jian-qiang Zhao, Jian Zuo, Xiao-Mei Zhang, Wei-Cheng Yuan, and Xiao-Ying Xu. "Organocatalytic asymmetric Michael addition of 3-substituted oxindoles to α,β-unsaturated acyl phosphonates for the synthesis of 3,3′-disubstituted oxindoles with chiral squaramides." Organic & Biomolecular Chemistry 13, no. 15 (2015): 4413–17. http://dx.doi.org/10.1039/c5ob00317b.

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5

Cheng, Wen-Fu, Ling-Yan Chen, Fang-Fang Xu, Wei-Yu Lin, Xinfeng Ren, and Ya Li. "Organocatalytic asymmetric Michael addition between 3-subsituted oxindoles and enals catalyzed by camphor sulfonyl hydrazine." Organic & Biomolecular Chemistry 17, no. 4 (2019): 885–91. http://dx.doi.org/10.1039/c8ob02934b.

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3,3-Disubstituted oxindoles containing vicinal stereogenic carbon centers have been synthesized through organocatalytic asymmetric Michael addition between 3-substituted oxindoles and enals catalyzed by chiral camphor sulfonyl hydrazines (CaSHs).
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6

Rao, Madhuri P., Shubha S. Gunaga, Johannes Zuegg, Rambabu Pamarthi, and Madhu Ganesh. "Highly regio- and diastereoselective [3 + 2]-cycloadditions involving indolediones and α,β-disubstituted nitroethylenes." Organic & Biomolecular Chemistry 17, no. 42 (2019): 9390–402. http://dx.doi.org/10.1039/c9ob01429b.

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7

Zhang, Chun-Lin, You-Feng Han, and Song Ye. "N-Heterocyclic carbene-catalyzed β-addition of enals to 3-alkylenyloxindoles: synthesis of oxindoles with all-carbon quaternary stereocenters." Chemical Communications 55, no. 55 (2019): 7966–69. http://dx.doi.org/10.1039/c9cc03099a.

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8

Krishnan, Shyam, and Brian M. Stoltz. "Preparation of 3,3-disubstituted oxindoles by addition of malonates to 3-halo-3-oxindoles." Tetrahedron Letters 48, no. 43 (October 2007): 7571–73. http://dx.doi.org/10.1016/j.tetlet.2007.08.131.

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9

Li, Man, Fu-Sheng He, Long-Shan Ji, Ya-Ting Gao, Xin Zhang, Zhuo Yu, Miao Fang, Jie Wu, and Yue-Qiu Gao. "Synthesis and biological evaluation of fluorinated 3,4-dihydroquinolin-2(1H)-ones and 2-oxindoles for anti-hepatic fibrosis." RSC Advances 11, no. 11 (2021): 5923–27. http://dx.doi.org/10.1039/d0ra09430g.

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10

Cao, An-Zhu, Yu-Ting Xiao, Yan-Chen Wu, Ren-Jie Song, Ye-Xiang Xie, and Jin-Heng Li. "Copper-catalyzed C–H [3 + 2] annulation of N-substituted anilines with α-carbonyl alkyl bromides via C(sp3)–Br/C(sp2)–H functionalization." Organic & Biomolecular Chemistry 18, no. 11 (2020): 2170–74. http://dx.doi.org/10.1039/d0ob00399a.

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Books on the topic "3-disubstituted oxindoles"

1

Pellissier, Hélène, Ramon Rios Torres, Renato Dalpozzo, and Swapandeep Singh Chimni. Asymmetric Synthesis of 3, 3-Disubstituted Oxindoles. World Scientific Publishing UK Limited, 2019.

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Book chapters on the topic "3-disubstituted oxindoles"

1

"3-Hetero-3-Substituted Oxindoles." In Asymmetric Synthesis of 3,3-Disubstituted Oxindoles, 271–302. WORLD SCIENTIFIC (EUROPE), 2019. http://dx.doi.org/10.1142/9781786347305_0006.

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2

"Enantioselective Synthesis of 3-Substituted-3-Hydroxyoxindoles." In Asymmetric Synthesis of 3,3-Disubstituted Oxindoles, 205–69. WORLD SCIENTIFIC (EUROPE), 2019. http://dx.doi.org/10.1142/9781786347305_0005.

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3

"Catalytic Asymmetric Synthesis of 3-Substituted-3-Amino-2-Oxindoles." In Asymmetric Synthesis of 3,3-Disubstituted Oxindoles, 151–204. WORLD SCIENTIFIC (EUROPE), 2019. http://dx.doi.org/10.1142/9781786347305_0004.

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You might also be interested in the extended bibliographies on the topic '3-disubstituted oxindoles' for particular source types:
Journal articles
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