Log in

Relevant bibliographies by topics / 3,4-Dihydro-2(1H)-quinolinone / Journal articles

To see the other types of publications on this topic, follow the link: 3,4-Dihydro-2(1H)-quinolinone.

Journal articles on the topic '3,4-Dihydro-2(1H)-quinolinone'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic '3,4-Dihydro-2(1H)-quinolinone.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Wu, Lingang, Yanan Hao, Yuxiu Liu, and Qingmin Wang. "NIS-mediated oxidative arene C(sp2)–H amidation toward 3,4-dihydro-2(1H)-quinolinone, phenanthridone, and N-fused spirolactam derivatives." Organic & Biomolecular Chemistry 17, no. 28 (2019): 6762–70. http://dx.doi.org/10.1039/c9ob01277j.

Full text

Abstract:

A new radical-mediated intramolecular arene C(sp²)–H amidation of 3-phenylpropanamides or [1,1′-biphenyl]-2-carboxamides was developed to prepare a series of 3,4-dihydro-2(1H)-quinolinone and phenanthridone derivatives in moderate to excellent yields (33–94%).

APA, Harvard, Vancouver, ISO, and other styles

2

Meiring, Letitia, Jacobus P. Petzer, and Anél Petzer. "Inhibition of monoamine oxidase by 3,4-dihydro-2(1H)-quinolinone derivatives." Bioorganic & Medicinal Chemistry Letters 23, no. 20 (October 2013): 5498–502. http://dx.doi.org/10.1016/j.bmcl.2013.08.071.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Tu, Shu-Jiang, Bo Jiang, Xiao-Tong Zhu, and Qiu-Yun Li. "Highly Efficient Synthesis of 3,4-Dihydro-2(1H)-quinolinone Derivatives under Microwave Heating." HETEROCYCLES 85, no. 7 (2012): 1615. http://dx.doi.org/10.3987/com-12-12489.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Zhao, He, Andrew Thurkauf, Julia Braun, Robin Brodbeck, and Andrzej Kieltyka. "Design, synthesis, and discovery of 3-piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives." Bioorganic & Medicinal Chemistry Letters 10, no. 18 (September 2000): 2119–22. http://dx.doi.org/10.1016/s0960-894x(00)00421-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Tsuritani, Takayuki, Yuhei Yamamoto, Masashi Kawasaki, and Toshiaki Mase. "Novel Approach to 3,4-Dihydro-2(1H)-quinolinone Derivatives via Cyclopropane Ring Expansion." Organic Letters 11, no. 5 (March 5, 2009): 1043–45. http://dx.doi.org/10.1021/ol802669r.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Oshiro, Yasuo, Yoji Sakurai, Seiji Sato, Nobuyuki Kurahashi, Tatsuyoshi Tanaka, Tetsuro Kikuchi, Katsura Tottori, Yasufumi Uwahodo, Takashi Miwa, and Takao Nishi. "3,4-Dihydro-2(1H)-quinolinone as a Novel Antidepressant Drug: Synthesis and Pharmacology of 1-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-3,4- dihydro-5-methoxy-2(1H)-quinolinone and Its Derivatives." Journal of Medicinal Chemistry 43, no. 2 (January 2000): 177–89. http://dx.doi.org/10.1021/jm980333v.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Zhu, Xiao-Tong, Qiu-yun Li, Bo Jiang, and Shu-Jiang Tu. "ChemInform Abstract: Highly Efficient Synthesis of 3,4-Dihydro-2(1H)-quinolinone Derivatives under Microwave Heating." ChemInform 43, no. 45 (October 11, 2012): no. http://dx.doi.org/10.1002/chin.201245178.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Oshiro, Yasuo, Yoji Sakurai, Seiji Sato, Nobuyuki Kurahashi, Tatsuyoshi Tanaka, Tetsuro Kikuchi, Katsura Tottori, Yasufumi Uwahodo, Takashi Miwa, and Takao Nishi. "ChemInform Abstract: 3,4-Dihydro-2(1H)-quinolinone as a Novel Antidepressant Drug: Synthesis and Pharmacology of 1-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl] -3,4-dihydro-5-methoxy-2(1H)-quinolinone and Its Derivatives." ChemInform 31, no. 16 (June 9, 2010): no. http://dx.doi.org/10.1002/chin.200016149.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Sun, Qun, Xiaoming Zhou, and Donald J. Kyle. "Solid-phase synthesis of 3,4-dihydro-2(1H)-quinazolinones and 3,4-dihydro-1H-quinazolin-2-thiones." Tetrahedron Letters 42, no. 25 (June 2001): 4119–21. http://dx.doi.org/10.1016/s0040-4039(01)00691-8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Rádl, Stanislav, Viktor Zikán, and František Šmejkal. "Syntheses of some N-carboxymethyl derivatives of 4,9-dihydro-3-methyl-4-oxo-1H-(2H)-pyrazolo[3,4-b]quinoline with antiviral effects." Collection of Czechoslovak Chemical Communications 50, no. 9 (1985): 2010–14. http://dx.doi.org/10.1135/cccc19852010.

Full text

Abstract:

The paper describes the syntheses of 4,9-dihydro-9-carboxymethyl-1,3-dimethyl-4-oxo-1H-pyrazolo[3,4-b]quinoline (Ic), 4,9-dihydro-9-carboxymethyl-2,3-dimethyl-4-oxo-2H-pyrazolo[3,4-b]quinoline (IIc), 4,9-dihydro-1-carboxymethyl-3-methyl-4-oxo-1H-pyrazolo[3,4-b]quinoline (Id), 4,9-dihydro-1-carboxymethyl-3,9-dimethyl-4-oxo-1H-pyrazolo[3,4-b]quinoline (If) and 4,9-dihydro-2-carboxymethyl-3,9-dimethyl-4-oxo-2H-pyrazolo[3,4-b]quinoline (IIf). The compounds were tested in vivo in mice for their efficacy against the virus A2-Hongkong and the encephalomyocarditis virus.

APA, Harvard, Vancouver, ISO, and other styles

11

Supriatno. "S-Phase Kinase-Associated Protein-2 and Nuclear Factor-kappa Beta as Molecular Targets of Oral Burkitt’s Lymphoma Cell Induced by Quinolinone Derivate-Vesnarinone." Current Signal Transduction Therapy 15, no. 2 (December 1, 2020): 88–93. http://dx.doi.org/10.2174/1574362413666180912113856.

Full text

Abstract:

Background: 3,4-Dihydro-6-[4-3,4-dimethoxybenzoyl-1-piperazinyl]-2(1H)-quinolinone (vesnarinone), a novel inotropic drug with unique and complex mechanisms of action, is known to show antitumor activity against several human malignancies. In the present study, vesnarinone-induced signal transduction of S-phase kinase-associated protein 2 (Skp2) and Nuclear Factor-kappa Beta (NF-κB) as molecular targets of oral malignant Burkitt’s lymphoma (Raji cells) was evaluated. Materials and Methods: Raji cells were incubated with vesnarinone at concentrations of 0, 1.25x10-2, 2.50x10-2, or 5.0x10-2 Molar. After 24 h, chemotactic cell migration was examined by a Boyden chamber kit. Apoptosis induction was observed by caspase-9 colorimetric assay. To evaluate levels of Skp2, NF-kB, and α-tubulin, Western blot analysis was performed. Results: Vesnarinone markedly suppressed chemotactic cell migration and significantly induced apoptosis by increasing the caspase-9 activity of Raji cells through down regulation of Skp2 and NF-κB. Conclusion: Vesnarinone decreased the expression of Skp2 and NF-κB indicating these molecules may be targeted for the treatment of oral malignant Burkitt’s lymphoma (BL). The results of this work offer a promising therapeutic approach for BL tumors.

APA, Harvard, Vancouver, ISO, and other styles

12

Yokozaki, Hiroshi, Reiko Ito, Shigehiro Ono, Ken Hayashi, and Eiichi Tahara. "Effect of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone (vesnarinone) on the growth of gastric cancer cell lines." Cancer Letters 140, no. 1-2 (June 1999): 121–28. http://dx.doi.org/10.1016/s0304-3835(99)00061-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

KODAMA, Kazuhisa, Shinsuke NANTO, and Michitoshi INOUE. "Phase I study of OPC-8212: 3,4-dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)-2(1H)-quinolinone, a new oral inotropic agent." Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 20, no. 4 (1989): 709–18. http://dx.doi.org/10.3999/jscpt.20.709.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Nath, Anisetti Ravinder, and Malladi Srinivas Reddy. "Design, Synthesis, Antibacterial and Antifungal Activity of Novel 2-[(E)-2-aryl-1-ethenyl]-3-(2-sulfanyl-1H-benzo[d]imidazole-5-yl)-3,4- dihydro-4-quinolinones." E-Journal of Chemistry 9, no. 3 (2012): 1481–89. http://dx.doi.org/10.1155/2012/795698.

Full text

Abstract:

The novel 2-[(E)-2-aryl-1-ethenyl]-3-(2-sulfanyl-1H-benzo[d]imidazole-5-yl)-3,4- dihydro-4-quinolinones (4a-j) analogs were synthesized by Knoevenagel condensation of a solution of 2-methyl-3-(2-sulfanyl-1H-benzo[d]imidazole-5-yl)-3,4-dihydro-4-quinazolinone (3) with aromatic aldehyde in presence of catalytic amount of piperidine. Compounds (4a-j) showed significant biological activity against all the standard strains. All the synthesized compounds were characterized on the basis of their IR,1H NMR, MASS spectroscopic data and elemental analyses. All the compounds have been tested for antimicrobial and antifungal activity by the cup-plate method.

APA, Harvard, Vancouver, ISO, and other styles

15

Rao, Nalla Krishna, Tentu Nageswara Rao, Botsa Parvatamma, Y. Prashanthi, and Ravi Kumar Cheedarala. "Novel Synthesis of 4-Benzylidene-2-((1-phenyl-3,4-dihydroisoquinoline-2(1H)-yl)methyl) oxazol-5(4H)-one Derivatives Using 1,2,3,Tetrahydroisoquinoline and their Antimicrobial Activity." Current Organic Synthesis 17, no. 5 (July 27, 2020): 396–403. http://dx.doi.org/10.2174/1570179417666200415151228.

Full text

Abstract:

Aims: A series of six 4-benzylidene-2-((1-phenyl-3,4-dihydro isoquinoline-2(1H)-yl)methyloxazol- 5(4H)-one derivatives were synthesized by condensation of substituted aryl aldehydes with 2-(2-(1-phenyl-3,4- dihydro isoquinoline-2(1H)-acetamido)acetic acid in the presence of sodium acetate, acetic anhydride and zinc oxide as catalysts. Background: Novel Synthesis of 4-Benzylidene-2-((1-phenyl-3,4-dihy droisoquinoline-2(1H)-yl)methyl)oxazol- 5(4H)-one derivatives using 1,2,3,Tetrahydroisoquinoline and their antimicrobial activity. Objective: The title compounds can be synthesized from 1,2,3,4-tetrahydroisoquinoline. Methods: The target molecules, i.e., 4-benzylidene-2-((1-phenyl-3, 4-dihydro isoquinoline-2(1H)-yl) methyl) oxazol-5(4H)-one derivatives (8a-8f) have been synthesized from 1,2,3,4-tetrahydroisoquinoline which was prepared from benzoic acid in few steps. Results: All the six compounds were evaluated based on advanced spectral data (1H NMR, 13C NMR & LCMS), and the chemical structures of all compounds were determined by elemental analysis. Conclusion: Antibacterial activity of the derivatives was examined for the synthesized compounds and results indicate that compound with bromine substitution has a good activity profile.

APA, Harvard, Vancouver, ISO, and other styles

16

Rádl, Stanislav, and Viktor Zikán. "Synthesis of 1,2, and 9-methyl derivatives of 4,9-dihydro-6-methoxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and 4,9-dihydro-6-hydroxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and their antiviral activity." Collection of Czechoslovak Chemical Communications 52, no. 3 (1987): 788–92. http://dx.doi.org/10.1135/cccc19870788.

Full text

Abstract:

The paper describes syntheses of 4,9-dihydro-6-methoxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline (Ia), its 1-methyl derivative (Ic), 1,9-dimethyl derivative (Ie), 2-methyl derivative (IIa), and 2,9-dimethyl derivative (IIc). Demethylation of these compounds with hydrobromic acid afforded 4,9-dihydro-6-hydroxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline (Ib), its 1-methyl derivative (Id), 1,9-dimethyl derivative (If), 2-methyl derivative (IIb), and 2,9-dimethyl derivative (IId) respectively. 4,9-Dihydro-6-hydroxy-3,9-dimethyl-4-oxo-1H-pyrazolo[3,4-b]quinoline (Ig) was prepared by demethylation of Ie and/or IIc with pyridine hydrochloride. The compounds prepared were tested for antiviral activity in vivo in mice against influenza virus A2-Hongkong and encephalomyocarditis virus.

APA, Harvard, Vancouver, ISO, and other styles

17

Fadel, Salah, Youssef Hajbi, Mostafa Khouili, Said Lazar, Franck Suzenet, and Gérald Guillaumet. "Synthesis of 3,4-dihydro-1,8-naphthyridin-2(1H)-ones via microwave-activated inverse electron-demand Diels–Alder reactions." Beilstein Journal of Organic Chemistry 10 (January 28, 2014): 282–86. http://dx.doi.org/10.3762/bjoc.10.24.

Full text

Abstract:

Substituted 3,4-dihydro-1,8-naphthyridin-2(1H)-ones have been synthesized with the inverse electron-demand Diels–Alder reaction from 1,2,4-triazines bearing an acylamino group with a terminal alkyne side chain. Alkynes were first subjected to the Sonogashira cross-coupling reaction with aryl halides, the product of which then underwent an intramolecular inverse electron-demand Diels–Alder reaction to yield 5-aryl-3,4-dihydro-1,8-naphthyridin-2(1H)-ones by an efficient synthetic route.

APA, Harvard, Vancouver, ISO, and other styles

18

Barluenga, José, Jesús Jardón, and Vicente Gotor. "Synthesis of 3,4-Dihydro-2(1H)-pyridinone Derivatives." Synthesis 1988, no. 02 (1988): 146–48. http://dx.doi.org/10.1055/s-1988-27496.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Prince, P., F. R. Fronczek, and R. D. Gandour. "Methyl 3,4-dihydro-1-oxo-2(1H)-naphthylidenehydroxyacetate." Acta Crystallographica Section C Crystal Structure Communications 45, no. 4 (April 15, 1989): 689–90. http://dx.doi.org/10.1107/s0108270188013162.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

TOMINAGA, MICHIAKI, HIDENORI OGAWA, EIYU YO, SHUJI YAMASHITA, YOUICHI YABUUCHI, and KAZUYUKI NAKAGAWA. "Studies on positive inotropic agents. IV. Synthesis of 5-(3-amino-2-hydroxypropoxy)-3,4-dihydro-8-hydroxy-2(1H)-quinolinone derivatives." CHEMICAL & PHARMACEUTICAL BULLETIN 35, no. 9 (1987): 3699–704. http://dx.doi.org/10.1248/cpb.35.3699.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Ali, Abdelselam A., and Kevin N. Winzenberg. "Preparation of 1-[(3-Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-pyridinone Derivatives from Aza Annulation Reactions of N-[(3-Trifluoromethyl)phenyl]-Substituted Enaminones." Australian Journal of Chemistry 58, no. 12 (2005): 870. http://dx.doi.org/10.1071/ch05188.

Full text

Abstract:

Reaction of 3-trifluoromethylaniline with the 1,3-diketones 1a–1c and 5a–5d affords the N-[(3-trifluoromethyl)phenyl]-substituted enaminones 2a–2c and 6a–6d. Reaction of 2a with the acryloyl chloride derivatives 3a–3c gives the 1-[(3-trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-pyridinones 4a, 4c, 4d; in a similar manner the 2(1H)-pyridinone 4b is obtained from 2b. Reaction of 6c, 6d with acryloyl chloride affords the 2,5(1H,3H)-quinolinedione derivatives 7 and 9 together with the acrylamides 8a, 8b. The 2(1H)-pyridinones 12a, 12b and the 3,4-dihydro-2(1H)-pyridinone 13 are prepared using routes involving the reaction of 2a with ethyl propiolate, dimethyl acetylenedicarboxylate, and maleic anhydride.

APA, Harvard, Vancouver, ISO, and other styles

22

Zlatkovic, Dragan, and Niko Radulovic. "Study of lithium aluminium hydride reduction of 5-acetyl-1,6-dimethyl-4-phenyl-3,4-dihydropyrimidin-2(1h)-one." Facta universitatis - series: Physics, Chemistry and Technology 15, no. 1 (2017): 17–22. http://dx.doi.org/10.2298/fupct1701017z.

Full text

Abstract:

In this paper, we investigated the LiAlH4-reduction of 5-acetyl-1,6-dimethyl- 4-phenyl-3,4-dihydropyrimidin-2(1H)-one (N-methylated Biginelli compound). Following the reduction and SiO2-promoted dehydration, (Z)-5-ethylidene-1-methyl-6- methylene-4-phenyltetrahydropyrimidin-2(1H)-one was isolated as the major product (33% yield). Chromatographic separation of the reaction products also allowed us to isolate (yield in parentheses) and fully spectrally characterize: 1,6-dimethyl-4-phenyl- 5-vinyl-3,4-dihydropyrimidin-2(1H)-one (20%), 5-ethyl-1,6-dimethyl-4-phenyl-3,4- dihydro-pyrimidin-2(1H)-one (9%), 5-(1-hydroxyethyl)-1,6-dimethyl-4-phenyl-3,4- dihydropyrimidin-2(1H)-one (5%). A possible mechanism explaining the formation of these products is proposed.

APA, Harvard, Vancouver, ISO, and other styles

23

Karpov, Sergey, Arthur Grigor’ev, Yakov Kayukov, Iuliia Gracheva, and Victor Tafeenko. "Cascade Regioselective Heterocyclization of 2-Acyl-1,1,3,3-tetracyanopropenides: Synthesis of Pyrrolo[3,4-c]pyridine and Pyrrolo[3,4-d]thieno[2,3-b]pyridine Derivatives." Synlett 28, no. 13 (May 2, 2017): 1592–95. http://dx.doi.org/10.1055/s-0036-1588823.

Full text

Abstract:

2-Acyl-1,1,3,3-tetracyanopropenides (ATCN) undergo cascade heterocyclization under the action of aliphatic thiols, resulting in the formation of 6-(alkylthio)-4-amino-1-aryl(alkyl)-1-hydroxy-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-7-carbonitriles. The involvement of methyl mercaptoacetate to this reaction leads to the formation of the methyl 4,8-diamino-1-aryl-1-hydroxy-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-d]thieno[2,3-b]pyridine-7-carboxylates, containing a new fused heterocyclic scaffold.

APA, Harvard, Vancouver, ISO, and other styles

24

Simonetti, Sebastián O., Enrique L. Larghi, and Teodoro S. Kaufman. "A convenient approach to an advanced intermediate toward the naturally occurring, bioactive 6-substituted 5-hydroxy-4-aryl-1H-quinolin-2-ones." Organic & Biomolecular Chemistry 14, no. 9 (2016): 2625–36. http://dx.doi.org/10.1039/c5ob02680f.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Kolosov, M. A., and V. D. Orlov. "Synthesis of derivatives of 5-(4,5-dihydro-1H-3-pyrazolyl)-3,4-dihydro-2(1H)-pyrimidone." Chemistry of Heterocyclic Compounds 45, no. 7 (July 2009): 873–75. http://dx.doi.org/10.1007/s10593-009-0343-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Castro, Rosane de P., Carolina da S. Matos, Cláudia A. do Nascimento, Cecília M. A. Oliveira, Lucília Kato, Luciano M. Lião, and José R. Sabino. "Absolute configuration of strictosidinic acid." Acta Crystallographica Section C Crystal Structure Communications 68, no. 4 (March 14, 2012): m94—m96. http://dx.doi.org/10.1107/s0108270112010372.

Full text

Abstract:

The absolute configuration of strictosidinic acid, (2S,3R,4S)-3-ethenyl-2-(β-D-glucopyranosyloxy)-4-{[(1S)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]methyl}-3,4-dihydro-2H-pyran-5-carboxylate, was determined from its sodium chloride trihydrate, poly[[diaqua((2S,3R,4S)-3-ethenyl-2-(β-D-glucopyranosyloxy)-4-{[(1S)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-2-ium-1-yl]methyl}-3,4-dihydro-2H-pyran-5-carboxylate)sodium] chloride monohydrate], {[Na(C26H32N2O9)(H2O)2]Cl·H2O}n. The strictosidinic acid molecule participates in intermolecular hydrogen bonds of the O—H...O and O—H...Cl types. The solid-state conformation was observed as a zwitterion, based on a charged pyridine N atom and a carboxylate group, the latter mediating the packing through coordination with the sodium cation.

APA, Harvard, Vancouver, ISO, and other styles

27

Soares, Júlio C. A. V., and Luiza R. S. Dias. "N′-Acetyl-3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine-4-carbohydrazide." Molbank 2020, no. 1 (January 7, 2020): M1104. http://dx.doi.org/10.3390/m1104.

Full text

Abstract:

Synthesis of N′-acetyl-3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine-4-carbohydrazide from the phenyl acetates of 3-acetyl-5-(3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine-4-yl)-2,3-dihydro-1,3,4-oxadiazol-2-yl in alkaline medium and its characterization by spectroscopic methods.

APA, Harvard, Vancouver, ISO, and other styles

28

B. Klimova, Tatiana, Elena I. Klimova, Simón O. Hernández, and Marcos G. Martínez. "Synthesis of Ferrocenyl-3,4-dihydro-1H-pyrimidin-2-ones." HETEROCYCLES 60, no. 10 (2003): 2231. http://dx.doi.org/10.3987/com-03-9831.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Srinivas, Avula, Malladi Sunitha, and Sriramoju Shamili. "Synthesis and Biological Evaluation of Novel Pyrane Glycosides." Acta Chimica Slovenica 67, no. 4 (December 15, 2020): 1061–71. http://dx.doi.org/10.17344/acsi.2019.5752.

Full text

Abstract:

A series of novel (5R)-5-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-3-(4-fluorophenyl)-2,6-diphenyl-3,3a,5,6-tetrahydro-2H-pyrazolo[3,4-d]thiazoles 11a–g and (5R)-5-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-3-(4-fluorophenyl)-6-phenyl-3,3a,5,6-tetrahydroisoxazolo[3,4-d]thiazoles 12a–g were synthesized by the reaction of chalcone derivatives of (R,Z)-2-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-5-(4-fluorobenzylidene)-3-phenylthiazolidin-4-ones 10a–g with phenylhydrazine and hydroxylamine hydrochloride. The chemical structures of newly synthesized compounds were elucidated by IR, NMR, MS and elemental analysis. The compounds 11a–g and 12a–g were evaluated for their antibacterial activity and antifungal activity.

APA, Harvard, Vancouver, ISO, and other styles

30

Henao, J. A., A. Palma, V. V. Kouznetsov, and J. M. Delgado. "X-ray powder diffraction data for two new N-substituted 3,4-dihydrospiro-2(1H) quinolines." Powder Diffraction 14, no. 4 (December 1999): 249–52. http://dx.doi.org/10.1017/s0885715600010617.

Full text

Abstract:

The X-ray powder diffraction patterns for two N-substituted tetrahydroquinolines are reported. N-(α-Chloroacetyl)-6-methoxy-3,4-dihydro-4-methylspiro[cyclohexane-1′,2(1H)quinoline], C18H24ClNO2, and N-(α-chloroacetyl)-6-chloro-3,4-dihydro-4-methylspiro[cyclohexane-1′,2(1H)-quinoline], C17H21Cl2NO are monoclinic, with refined unit cell parameters a=1.4471(3), b=0.9600(4), c=1.1948(3) nm, β=93.21(2)°, V=1.6573(6) nm3, Z=4, Dx=1.29 gcm−3, and a=1.4487(3), b=0.9878(2), c=1.1390(2) nm, β=91.66(2)°, V=1.6294(4) nm3, Z=4, and Dx=1.32 gcm−3, respectively, with space group P21/n (No. 14).Key words: powder diffraction data, spirotetrahydroquinolines.

APA, Harvard, Vancouver, ISO, and other styles

31

Li, Baihui, Yangli Shen, Hu Wu, Xiaobo Wu, Lvjiang Yuan, and Qinggang Ji. "Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents." European Journal of Medicinal Chemistry 195 (June 2020): 112278. http://dx.doi.org/10.1016/j.ejmech.2020.112278.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Oleshchuk, Alena L., Zarina T. Shulgau, Tulegen M. Seilkhanov, Alexey S. Vasilchenko, Samat A. Talipov, and Ivan V. Kulakov. "Synthesis and Biological Activity of 4-(Pyridin-3-yl)-2-hydroxy-4-oxobut-2-enoic Acid Derivatives." Synlett 31, no. 02 (November 29, 2019): 165–70. http://dx.doi.org/10.1055/s-0037-1610738.

Full text

Abstract:

Claisen condensation reaction of diethyl oxalate with 1-[4-(furan-2-yl)-2-methyl-5-nitro-6-phenylpyridin-3-yl]ethan-1-one afforded (Z)-4-[4-(furan-2-yl)-2-methyl-5-nitro-6-phenylpyridin-3-yl]-2-hydroxy-4-oxobut-2-enoic acid. The latter reacted with various binucleophiles to form the corresponding 3,4-dihydroquinoxaline-2(1H)-one, 3,4-dihydro-2H-benzo[b][1,4]oxazin-2-one, and 1H-pyrazole derivatives. Biological screening of the obtained compounds revealed analgesic and antibacterial activity.

APA, Harvard, Vancouver, ISO, and other styles

33

Sharma, Nutan, Pankaj Sharma, and Sunita Bhagat. "Eco-friendly reactions in PEG-400: a highly efficient and green approach for stereoselective access to multisubstituted 3,4-dihydro-2(1H)-quinazolines using 2-aminobenzylamines." RSC Advances 8, no. 16 (2018): 8721–31. http://dx.doi.org/10.1039/c7ra13487h.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Nakai, S., K. Aihara, K. Kawai, K. Ogino, F. Saitou, M. Sato, and M. Adachi. "139. Differentiation-inducing activity of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piper-azinyl]-2(1H)-quinolinone (vesnarinone) against tumor leukemia and solid tumor cells." Biomedicine & Pharmacotherapy 46, no. 5-7 (January 1992): 308. http://dx.doi.org/10.1016/0753-3322(92)90224-u.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Xia, Ai-Bao, Xiao-Long Zhang, Tao Wang, Xiao-Hua Du, Dan-Qian Xu, and Zhen-Yuan Xu. "Enantioselective synthesis of functionalized 3,4-disubstituted dihydro-2(1H)-quinolinones via Michael–hemiaminalization/oxidation reaction." New Journal of Chemistry 39, no. 7 (2015): 5088–91. http://dx.doi.org/10.1039/c4nj01718h.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Sawant, Rajiv, Marc Stevens, and Luke Odell. "3,4-Dihydro-3-(2-hydroxyethyl)-4-(nitromethyl)quinazolin-2(1H)-one." Molbank 2015, no. 3 (July 10, 2015): M866. http://dx.doi.org/10.3390/m866.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Tanzawa, Toru, Naohiro Shirai, Yoshiro Sato, Keiichiro Hatano, and Yukihisa Kurono. "Rearrangement of 1-phenyl-3,4-dihydro-1H-2-benzothiopyranium 2-methylides." Journal of the Chemical Society, Perkin Transactions 1, no. 22 (1995): 2845. http://dx.doi.org/10.1039/p19950002845.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Launikonis, A., WHF Sasse, and IR Willing. "The Action of Trifluoromethanesulfonic Acid on Naphthalene." Australian Journal of Chemistry 46, no. 4 (1993): 427. http://dx.doi.org/10.1071/ch9930427.

Full text

Abstract:

Trifluoromethanesulfonic ( triflic ) acid reacts with naphthalene at room temperature to give a complex mixture from which five products have been isolated and identified as follows: (E)-3-benzylidene-2,3-dihydro-1H-benz[e]indene (2) (yield 15-20%), 1,2,3,4-tetrahydroanthracene (7) (c. 0.5%), 4-phenyl-1,2-dihydroanthracene (8), 3,4-dihydro-1,2′-binaphthyl (9a′), 4-(2-naphthyl)-1,2-dihydroanthracene (10) [yields of (8), (9a′) and (10) each less than 0.1%]. Also formed is (Z)-2-benzylidene-1,3-dihydro-1H-benz[e]indene (6) which is formed reversibly from (2) by the action of triflic acid. Mechanisms are proposed for the formation of these products.

APA, Harvard, Vancouver, ISO, and other styles

39

Petronijević, Jelena, Nenad Janković, Tatjana P. Stanojković, Nenad Joksimović, Nađa Đ. Grozdanić, Milan Vraneš, Aleksandar Tot, and Zorica Bugarčić. "Biological evaluation of selected 3,4-dihydro-2(1H )-quinoxalinones and 3,4-dihydro-1,4-benzoxazin-2-ones: Molecular docking study." Archiv der Pharmazie 351, no. 5 (April 14, 2018): 1700308. http://dx.doi.org/10.1002/ardp.201700308.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

HORI, Masatsugu, Michitoshi INOUE, Jun TAMAI, Yukihiro KORETSUNE, Masafumi KITAKAZE, Kunimitsu IWAI, Katsuomi IWAKURA, Akira KITABATAKE, and Takenobu KAMADA. "Beneficial effect of OPC-8212 (3,4-dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)-2(1H)-quinolinone) on myocardial oxygen consumption in dogs with ischemic heart failure." Japanese Circulation Journal 50, no. 7 (1986): 659–66. http://dx.doi.org/10.1253/jcj.50.659.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Babu Mareyala, Hari. "Addition of 2(1H)-Pyridinethione to 3,4-Dihydro(2H)-pyran." HETEROCYCLES 24, no. 9 (1986): 2403. http://dx.doi.org/10.3987/r-1986-09-2403.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Filimonov, Sergei I. "Reactions of resorcinol with substituted 3,4-dihydro-2(1H)-pyrimidinethiones." Mendeleev Communications 9, no. 6 (January 1999): 252–53. http://dx.doi.org/10.1070/mc1999v009n06abeh001151.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Brown, Christopher L., Sarah J. Head, and Peter C. Healy. "1,1-Dibenzyl-6-methoxy-3,4-dihydro-1H-naphthalen-2-one." Acta Crystallographica Section E Structure Reports Online 58, no. 2 (January 25, 2002): o178—o179. http://dx.doi.org/10.1107/s1600536802000715.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Nayak, Soukhyarani, and Boja Poojary. "4-[(3,4-Dimethoxybenzylidene)amino]-5-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione." Molbank 2019, no. 1 (March 29, 2019): M1055. http://dx.doi.org/10.3390/m1055.

Full text

Abstract:

4-Amino-5-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (1) upon treatment with 3,4-dimethoxybenzaldehyde in 10 mL of absolute ethanol in the presence of a catalytic amount of acetic acid produced the target compound 4-[(3,4-dimethoxybenzylidene)amino]-5-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (2) in 80% yield. The obtained solid product was recrystallized from ethanol. The compound was characterized by elemental analyses, mass spectrometry, FT-IR, 1H and 13C-NMR spectroscopy. To study the binding interactions of the compound with receptor, it was docked with the human prostaglandin reductase (PTGR2). The docking pose and noncovalent interactions gave insights into its plausible inhibitory action.

APA, Harvard, Vancouver, ISO, and other styles

45

Altıntop, Mehlika Dilek. "Synthesis, In vitro and In silico Evaluation of a Series of Pyrazolines as New Anticholinesterase Agents." Letters in Drug Design & Discovery 17, no. 5 (May 18, 2020): 574–84. http://dx.doi.org/10.2174/1570180816666190618111023.

Full text

Abstract:

Background: Pyrazolines, electron-rich nitrogen carriers, are of great importance due to their potential applications for the treatment of many diseases including inflammation, infectious diseases and neurodegenerative disorders. Objectives: The purpose of this work was to synthesize new pyrazoline derivatives and evaluate their anticholinesterase effects. Methods: 1-Aryl-5-[4-(piperidin-1-yl)phenyl]-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazoles (1-7) were synthesized via the treatment of 1-(3,4-dimethoxyphenyl)-3-[4-(piperidin-1-yl)phenyl]prop-2- en-1-one with arylhydrazine hydrochloride derivatives in acetic acid, whereas 1-aryl-5-[4- (morpholin-4-yl)phenyl]-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazoles (8-14) were obtained by the treatment of 1-(3,4-dimethoxyphenyl)-3-[4-(morpholin-4-yl)phenyl]prop-2-en-1-one with arylhydrazine hydrochloride derivatives in acetic acid. Their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were determined using a modification of Ellman’s spectrophotometric method. In silico docking and Absorption, Distribution, Metabolism and Excretion (ADME) studies were performed using Schrödinger’s Maestro molecular modeling package. Results: In general, piperidine derivatives were found to be more effective than morpholine derivatives on cholinesterases (ChEs). 1-Phenyl-5-[4-(piperidin-1-yl)phenyl]-3-(3,4-dimethoxyphenyl)- 4,5-dihydro-1H-pyrazole (1) and 1-(4-cyanophenyl)-5-[4-(piperidin-1-yl)phenyl]-3-(3,4- dimethoxyphenyl)-4,5-dihydro-1H-pyrazole (7) were identified as the most effective AChE inhibitors in this series with 40.92% and 38.98%, respectively. Compounds 1 and 7 were docked into the active site of human AChE (PDB code: 4EY7). Both the compounds were found to be capable of forming π-π stacking interactions with Trp286. Based on in silico ADME studies, these compounds are expected to have reasonable oral bioavailability. Conclusion: In the view of this work, the structural modification of the identified agents is going on for the generation of new anticholinesterase agents with enhanced efficacy.

APA, Harvard, Vancouver, ISO, and other styles

46

Dachriyanus, Melvyn V. Sargent, Brian W. Skelton, and Allan H. White. "Cycloadducts of Benzynes and 3,4-Dimethoxyfuran." Australian Journal of Chemistry 53, no. 4 (2000): 267. http://dx.doi.org/10.1071/ch99116.

Full text

Abstract:

Cycloaddition between benzyne and 3,4-dimethoxyfuran (1) yielded 2,3-dimethoxy-1,4-dihydro-1,4- epoxynaphthalene (3) which was unusually labile. On chromatography and exposure to air, it yielded (1α,3β,4α)-3-methoxy-3,4-dihydro-1,4-epoxynaphthalen-2(1H)-one (4) and (5α,5aβ,6aα,7β,12β,12aα,13aβ,14α)-6a,12a,13a-tri-methoxy-6a,7,12,12a,13a,14-hexahydro-5,14:7,12-diepoxydinaphtho[2,3-b:2′,3′-e][1,4]dioxin-5a(5H)-ol (19). A single-crystal X-ray structure determination was performed on compound (19). The chemistry of the ketone (4) was investigated. Cycloadditions were also carried out with 3,4-dimethoxyfuran (1) and methoxy-substituted benzynes. The regiochemistry of hydrolysis of the resultant adducts was explored.

APA, Harvard, Vancouver, ISO, and other styles

47

Miyazaki, Shunichi, Shigetake Sasayama, Yasuyuki Nakamura, Yasuki Kihara, Takashi Susawa, and Chuichi Kawai. "Acute Hemodynamic Effects of a New Positive Inotropic Agent, 3,4-Dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone (OPC-8212), in Conscious and Anesthetized Dogs." Journal of Cardiovascular Pharmacology 8, no. 1 (January 1986): 14–20. http://dx.doi.org/10.1097/00005344-198601000-00003.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Lan, Yu, Yin Chen, Xiangqing Xu, Yinli Qiu, Shicheng Liu, Xin Liu, Bi-Feng Liu, and Guisen Zhang. "Synthesis and biological evaluation of a novel sigma-1 receptor antagonist based on 3,4-dihydro-2(1H)-quinolinone scaffold as a potential analgesic." European Journal of Medicinal Chemistry 79 (May 2014): 216–30. http://dx.doi.org/10.1016/j.ejmech.2014.04.019.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Jang, Miyoung, Youri Oh, Hyunwook Cho, Songyi Yang, Hyungwoo Moon, Daseul Im, and Jung-Mi Hah. "Discovery of 1-Pyrimidinyl-2-Aryl-4,6-Dihydropyrrolo [3,4-d]Imidazole-5(1H)-Carboxamide as a Novel JNK Inhibitor." International Journal of Molecular Sciences 21, no. 5 (March 2, 2020): 1698. http://dx.doi.org/10.3390/ijms21051698.

Full text

Abstract:

We designed and synthesized 1-pyrimidinyl-2-aryl-4, 6-dihydropyrrolo [3,4-d] imidazole-5(1H)-carboxamide derivatives as selective inhibitors of c-Jun-N-terminal Kinase 3 (JNK3), a target for the treatment of neurodegenerative diseases. Based on the compounds found in previous studies, a novel scaffold was designed to improve pharmacokinetic characters and activity, and compound 18a, (R)-1-(2-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)amino)pyrimidin-4-yl)-2-(3,4-dichlorophenyl)-4,6-dihydro pyrrolo [3,4-d]imidazole-5(1H)-carboxamide, showed the highest IC50 value of 2.69 nM. Kinase profiling results also showed high selectivity for JNK3 among 38 kinases, having mild activity against JNK2, RIPK3, and GSK3β, which also known to involve in neuronal apoptosis.

APA, Harvard, Vancouver, ISO, and other styles

50

Maas, Gerhard, Robert Reinhard, and Hans-Georg Herz. "Two-Carbon Ring Enlargement of Five-, Six-, and Seven-Membered 1-Aza-2-vinylcycloalk-2-enes with Dimethyl Acetylenedicarboxylate and Subsequent Thermal Isomerization Reactions." Zeitschrift für Naturforschung B 61, no. 4 (April 1, 2006): 385–95. http://dx.doi.org/10.1515/znb-2006-0404.

Full text

Abstract:

2-Aminodienes, in which the enamine function is incorporated in a five-, six-, or seven-membered ring, react with dimethyl acetylenedicarboxylate in a sequence of [2+2] cycloaddition and electrocyclic ring-opening to form the two-carbon ring expanded unsaturated heterocycles, i.e., 3,4- dicarboxylate substituted 6,7-dihydro-1H-azepines 3, 8 and 21, 1,6,7,8-tetrahydroazocines 22, and 6,7,8,9-tetrahydro-1H-azonines 13. Similarly, 2-[(2-thienyl)ethynyl]-4,5,6,7-tetrahydro-1H-azepine 9 is converted into 2-[(2-thienyl)ethynyl]-6,7,8,9-1H-azonine-3,4-dicarboxylate 10 which was characterized by X-ray structure determination. The eight- and nine-membered azaheterocycles 22 and 13, which have not been isolated, undergo thermal isomerization at elevated temperatures. Thus, ring contraction by a 6π-electrocyclic reaction takes place for N-methyl substituted azonine 13, while the N-allyl moiety of azocines 22 engages in an intramolecular Diels-Alder reaction or a 1,7- electrocyclization reaction

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!