Relevant bibliographies by topics / 2GDT

Academic literature on the topic '2GDT'

Author: Grafiati
Published: 27 July 2024
Last updated: 31 July 2024

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Journal articles on the topic "2GDT"

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Andrews, GA, PS Chavey, JE Smith, and L. Rich. "N-glycolylneuraminic acid and N-acetylneuraminic acid define feline blood group A and B antigens." Blood 79, no. 9 (May 1, 1992): 2485–91. http://dx.doi.org/10.1182/blood.v79.9.2485.2485.

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Abstract Blood group incompatibility causes transfusion reactions and neonatal isoerythrolysis in cats. We investigated the molecular nature of the blood group antigens from cats that had blood type A, B, and AB erythrocytes. Naturally occurring anti-type B antibodies, Triticum vulgaris lectin, monoclonal antibody (MoAb) 32–27, and MoAb R-24 were used in agglutination tests, Western blots, and thin-layer chromatography (TLC) enzyme immunostaining. Type A erythrocytes had NeuGc-NeuGc-Galactose-Glucose-Ceramide ([NeuGc]2GD3) where NeuGc represents N-glycolylneuraminic acid, and NeuAc-NeuGc-GD3, where NeuAc represents N-acetylneuraminic acid, and may have [NeuGc]2 disialylparagloboside and NeuAc-NeuGc-disialylparagloboside. Type B erythrocytes only had [NeuAc]2GD3. Type AB erythrocytes had [NeuGc]2GD3, NeuAc-NeuGc-GD3, and [NeuAc]2GD3. Blood group antigens were also found on a 50-Kd membrane protein. We conclude that type B erythrocytes are characterized by [NeuAc]2GD3 as the only form of this ganglioside and the presence of NeuAc on a 50-Kd membrane protein. NeuGc is the major determinant of the A antigen; specifically, [NeuGc]2GD3 is the major glycolipid form. The A antigen is also present on a 50-Kd membrane protein.
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2

Andrews, GA, PS Chavey, JE Smith, and L. Rich. "N-glycolylneuraminic acid and N-acetylneuraminic acid define feline blood group A and B antigens." Blood 79, no. 9 (May 1, 1992): 2485–91. http://dx.doi.org/10.1182/blood.v79.9.2485.bloodjournal7992485.

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Blood group incompatibility causes transfusion reactions and neonatal isoerythrolysis in cats. We investigated the molecular nature of the blood group antigens from cats that had blood type A, B, and AB erythrocytes. Naturally occurring anti-type B antibodies, Triticum vulgaris lectin, monoclonal antibody (MoAb) 32–27, and MoAb R-24 were used in agglutination tests, Western blots, and thin-layer chromatography (TLC) enzyme immunostaining. Type A erythrocytes had NeuGc-NeuGc-Galactose-Glucose-Ceramide ([NeuGc]2GD3) where NeuGc represents N-glycolylneuraminic acid, and NeuAc-NeuGc-GD3, where NeuAc represents N-acetylneuraminic acid, and may have [NeuGc]2 disialylparagloboside and NeuAc-NeuGc-disialylparagloboside. Type B erythrocytes only had [NeuAc]2GD3. Type AB erythrocytes had [NeuGc]2GD3, NeuAc-NeuGc-GD3, and [NeuAc]2GD3. Blood group antigens were also found on a 50-Kd membrane protein. We conclude that type B erythrocytes are characterized by [NeuAc]2GD3 as the only form of this ganglioside and the presence of NeuAc on a 50-Kd membrane protein. NeuGc is the major determinant of the A antigen; specifically, [NeuGc]2GD3 is the major glycolipid form. The A antigen is also present on a 50-Kd membrane protein.
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3

Vladimirova, Liubov Yu, Oleg Ivanovich Kit, Elena A. Nikipelova, and Natalya A. Abramova. "Results of monoclonal antibodies against EGFR-receptors application in patients with metastatic colorectal cancer (mCRC)." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): e14701-e14701. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e14701.

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e14701 Background: Monoclonal antibodies against the epidermal growth factor receptor(EGFR)are standard components of treatment in mCRC.This study was designed to evaluate the tolerability and efficacy of the combinations of Panitumumab(P) and Cetuximab(C) with chemotherapy in patients with wild type(WT) KRAS tumors mCRC. Methods: Mutation analysis of KRAS(codons12,13) was done on samples at diagnosis. Key elegibility criteria included measurable mCRC stage IV, ECOG ≤2, adequate liver,kidney and bone marrow function, no brain metastases. P was administered 6mg/ kg 1 day q2w. C was administered 400mg/m² 1day and 250mg/m² q1w. Combination with FOLFOX-6 or FOLFIRI pegimens was allowed. Endpoints include response rate, OS, PFS and safety. Results: Of 38 testable samples there were 21(55.3%) WT KRAS tumors. All of these 21 (13male and 8female) pts were recruited. Mean age was 58.1±12.3. Synchronous metastases had 33.3%(7pts). Majority of pts benefited from anti-EGFR combined with cytotoxic chemotherapy 80.9% (17), mostly FOLFIRI – 57,1%(12).There were23.8%(5) in the 1st line CT, 76.1%(16) in the 2nd line CT. 6 mos of the treatment were analyzed. Overall RR was76.1 %(16) including 6PR(28.5%) and 10SD(47.6%). Med OS= 9.1mo, Med PFS= 4.3mo. 8 pts(38.1%) are alive till the abstract submission. Most common toxicities were:skin rash 2/3Gd.-90.5%(19), xeroderma 2Gd.-42.9%(9),skin itch 1/3Gd.-42.9%(9), paronychia 2Gd. -14.2%(3), purulent psorophthalmia 2Gd.-14.2%(3). All kinds of toxicities were controlled by symptomatic medication if necessary and did not lead to anti-EGFR agents dalay. Besides,diarrhea 1/2Gd.- 66.7%(14), 3Gd.-14.3%(3), neutropenia 1/2Gd.-28.6%(6), 3/4Gd.-9.5%(2), nausea 3/4Gd.- 14.3%(3), vomiting 1/2Gd.- 42.9%(9), fatigue 1/2Gd.-47.6%(10). Conclusions: These results consider significant efficacy of anti-EGFR agents combined with CT in pts with mCRC. Controlled toxicity of the therapy allows to use it widely.
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Дудникова, В. Б., Д. И. Антонов, Е. В. Жариков, and Н. Н. Еремин. "Твердые растворы CaMoO-=SUB=-4-=/SUB=--NaGd(MoO-=SUB=-4-=/SUB=-)-=SUB=-2-=/SUB=-: моделирование свойств и локальной структуры методом межатомных потенциалов." Физика твердого тела 64, no. 11 (2022): 1741. http://dx.doi.org/10.21883/ftt.2022.11.53328.413.

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Проведено моделирование твердых растворов CaMoO4-NaGd(MoO4)2 методом межатомных потенциалов. Показано, что твердые растворы существуют во всем диапазоне составов и близки к идеальным. Получены зависимости от состава параметров и объема элементарной ячейки, плотности, модуля объемной упругости, энтальпии, колебательной энтропии и теплоемкости. Построены температурные зависимости теплоемкости и колебательной энтропии. Анализ локальной структуры и ее изменения в зависимости от состава твердого раствора Ca1-xNax/2Gdx/2MoO4 показал, что в твердом растворе межатомные расстояния Gd-O в среднем на 2.62% меньше, а Na-O на 3.15% больше расстояний Ca-O. В целом это приводит к увеличению параметров и объема элементарной ячейки при образовании твердых растворов Ca1-xNax/2Gdx/2MoO4 по сравнению с CaMoO4. Ключевые слова: моделирование, молибдаты, твердые растворы, локальная структура.
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Kerkelä, Risto, Sara Karsikas, Zoltan Szabo, Raisa Serpi, Johanna Magga, Erhe Gao, Kari Alitalo, et al. "Activation of Hypoxia Response in Endothelial Cells Contributes to Ischemic Cardioprotection." Molecular and Cellular Biology 33, no. 16 (June 17, 2013): 3321–29. http://dx.doi.org/10.1128/mcb.00432-13.

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Small-molecule inhibition of hypoxia-inducible factor prolyl 4-hydroxylases (HIF-P4Hs) is being explored for the treatment of anemia. Previous studies have suggested that HIF-P4H-2 inhibition may also protect the heart from an ischemic insult.Hif-p4h-2gt/gtmice, which have 76 to 93% knockdown ofHif-p4h-2mRNA in endothelial cells, fibroblasts, and cardiomyocytes and normoxic stabilization of Hif-α, were subjected to ligation of the left anterior descending coronary artery (LAD). Hif-p4h-2 deficiency resulted in increased survival, better-preserved left ventricle (LV) systolic function, and a smaller infarct size. Surprisingly, a significantly larger area of the LV remained perfused during LAD ligation inHif-p4h-2gt/gthearts than in wild-type hearts. However, no difference was observed in collateral vessels, while the size of capillaries, but not their number, was significantly greater inHif-p4h-2gt/gthearts than in wild-type hearts.Hif-p4h-2gt/gtmice showed increased cardiac expression of endothelial Hif target genes for Tie-2, apelin, APJ, and endothelial nitric oxide (NO) synthase (eNOS) and increased serum NO concentrations. Remarkably, blockage of Tie-2 signaling was sufficient to normalize cardiac apelin and APJ expression and resulted in reversal of the enlarged-capillary phenotype and ischemic cardioprotection inHif-p4h-2gt/gthearts. Activation of the hypoxia response by HIF-P4H-2 inhibition in endothelial cells appears to be a major determinant of ischemic cardioprotection and justifies the exploration of systemic small-molecule HIF-P4H-2 inhibitors for ischemic heart disease.
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Tian, He, Liangliang Wei, and Limin He. "Phase Composition and Stability, Sintering and Thermal Conductivity of Gd2O3 and Yb2O3 Co-Doped YSZ." Coatings 13, no. 1 (December 28, 2022): 53. http://dx.doi.org/10.3390/coatings13010053.

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Y2O3-stabilized ZrO2 (YSZ) has been the material of choice for thermal barrier coatings (TBCs) in the past decades, yet its phase decomposition limits its application above 1200 °C. In this study, Gd2O3 and Yb2O3 co-doped YSZ powders were produced, in which some amounts of monoclinic (m) phase were introduced into the cubic (c) phase matrix. XRD results showed that the fabricated powders obtained by a solid phase synthesis were composed of m and c phases, and hat the m phase content decreased in a sequence of 4Gd-2Yb-4Y, 2Gd-2Yb-6Y and 2Gd-4Yb-4Y powders. This indicated that Yb3+ is an excellent stabilizer in the ZrO2-based lattice, which could largely suppress the formation of the m phase. The m phase content in the powders was almost kept unchanged with heating at 1300 °C, which could provide a toughening effect to the ceramic. All the powders exhibited no obvious sintering at 1300 °C for 150 h. As compared to YSZ, the three fabricated ceramics had lower thermal conductivities, and they increased in a sequence of 4Gd-2Yb-4Y, 2Gd-4Yb-4Y and 2Gd-2Yb-6Y.
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Dudnikova V. B, Antonov D. I., Zharikov E. V., and Eremin N. N. "CaMoO-=SUB=-4-=/SUB=--NaGd(MoO-=SUB=-4-=/SUB=-)-=SUB=-2-=/SUB=- Solid Solutions: simulation of properties and local structure by the method of interatomic potentials." Physics of the Solid State 64, no. 11 (2022): 1713. http://dx.doi.org/10.21883/pss.2022.11.54195.413.

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Simulation of CaMoO4-NaGd(MoO4)2 solid solutions by the method of interatomic potentials is carried out. It is shown that solid solutions exist in the entire range of compositions and are close to ideal. Dependences on the composition of the lattice parameters and volume of the unit cell, density, bulk modulus, enthalpy, vibrational entropy and heat capacity are obtained. Temperature dependences of heat capacity and vibrational entropy are constructed. Analysis of the local structure and its changes depending on the composition of the Ca1-xNax/2Gdx/2MoO4 solid solution showed that in solid solution the interatomic distances of Gd-O are on average 2.62% less, and Na-O is 3.15% greater than the distances of Ca-O. In general, this leads to an increase in the lattice parameters and volume of the unit cell during the formation of Ca1-xNax/2Gdx/2MoO4 solid solutions compared to CaMoO4. Keywords: simulation, molybdates, the solid solutions, local structure.
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8

Laitala, Anu, Ellinoora Aro, Gail Walkinshaw, Joni M. Mäki, Maarit Rossi, Minna Heikkilä, Eeva-Riitta Savolainen, et al. "Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis." Blood 120, no. 16 (October 18, 2012): 3336–44. http://dx.doi.org/10.1182/blood-2012-07-441824.

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AbstractAn endoplasmic reticulum transmembrane prolyl 4-hydroxylase (P4H-TM) is able to hydroxylate the α subunit of the hypoxia-inducible factor (HIF) in vitro and in cultured cells, but nothing is known about its roles in mammalian erythropoiesis. We studied such roles here by administering a HIF-P4H inhibitor, FG-4497, to P4h-tm−/− mice. This caused larger increases in serum Epo concentration and kidney but not liver Hif-1α and Hif-2α protein and Epo mRNA levels than in wild-type mice, while the liver Hepcidin mRNA level was lower in the P4h-tm−/− mice than in the wild-type. Similar, but not identical, differences were also seen between FG-4497–treated Hif-p4h-2 hypomorphic (Hif-p4h-2gt/gt) and Hif-p4h-3−/− mice versus wild-type mice. FG-4497 administration increased hemoglobin and hematocrit values similarly in the P4h-tm−/− and wild-type mice, but caused higher increases in both values in the Hif-p4h-2gt/gt mice and in hematocrit value in the Hif-p4h-3−/− mice than in the wild-type. Hif-p4h-2gt/gt/P4h-tm−/− double gene-modified mice nevertheless had increased hemoglobin and hematocrit values without any FG-4497 administration, although no such abnormalities were seen in the Hif-p4h-2gt/gt or P4h-tm−/− mice. Our data thus indicate that P4H-TM plays a role in the regulation of EPO production, hepcidin expression, and erythropoiesis.
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Hu, Yaobo, Chao Zhang, Tianxu Zheng, Fusheng Pan, and Aitao Tang. "Strengthening Effects of Zn Addition on an Ultrahigh Ductility Mg-Gd-Zr Magnesium Alloy." Materials 11, no. 10 (October 11, 2018): 1942. http://dx.doi.org/10.3390/ma11101942.

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A newly developed Mg-2Gd-0.5Zr-xZn (x = 0.5, 1.0, 2.0, 3.0 wt %) alloy system exhibits significant strengthening by doping with Zn. In order to understand the strengthening mechanism, the microstructure, texture evolution, and mechanical properties of ultrahigh ductility Mg-2Gd-0.5Zr alloys with a Zn addition were systematically investigated. The addition of Zn results in the formation of Mg-Gd-Zn intermetallic compounds along grain boundaries, which encourages grain refinement during hot extrusion via the particle stimulated nucleation (PSN) mechanism. Furthermore, during texture sharpening the pole changes from <20 2 ¯ 1> to <01 1 ¯ 0>, which also occurred in the extruded alloys with Zn addition, which is unfavorable for the basal slip and tensile twinning. Mg-2Gd-0.5Zr-3Zn shows well-balanced strength and ductility with a tensile yield strength (YS) and ultimate tensile strength (UTS) of 285 and 314 MPa, accompanied by a high tensile elongation of 24%. They are superior to those of commercial AZ31. The enhanced strength is attributed to grain refinement, precipitation strengthening, and texture sharpening induced by alloying with Zn. The research result is also of great value to the development of low rare-earth, high strength, and high room temperature ductility magnesium alloy.
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Myllymäki, Mikko, Jenni Määttä, Elitsa Dimova, Valerio Izzi, Timo Väisänen, Johanna Myllyharju, Peppi Koivunen, and Raisa Serpi. "Extramedullary Erythropoiesis in Spleen of HIF Prolyl 4-Hydroxylase-2 Deficient Mice Is Mediated By Notch Signaling Downregulation." Blood 128, no. 22 (December 2, 2016): 2656. http://dx.doi.org/10.1182/blood.v128.22.2656.2656.

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Abstract Erythrocytosis, an increase in absolute red cell mass, is mainly driven by erythropoietin, while hypoxia-inducible factor (HIF) regulates the expression of a number of genes involved in it, including erythropoietin. Mutations in HIF prolyl 4-hydroxylase 2 (HIF-P4H-2/PHD2/EGLN1), the major regulator of the stability of HIFα subunits, are found in familiar erythrocytosis, and large-spectrum conditional inactivation of HIF-P4H-2 in mice leads to severe erythrocytosis and premature death. Although bone marrow is the primary site for erythropoiesis, spleen retains a capability for extramedullary erythropoiesis. We studied HIF-P4H-2 hypomorphic mice (Hif-p4h-2gt/gt) which show slightly induced erythropoiesis only upon aging despite no increased erythropoietin levels. Spleen was identified as the site of extramedullary erythropoiesis in these mice. Hematopoietic stem cells (HSCs) from spleens of the Hif-p4h-2gt/gt mice showed increased growth of BFU-Es and the mice were protected against anemia by induced extramedullary erythropoiesis. HIF-1α and HIF-2α were stabilized in the spleens, while the Notch ligands and target Jag1, Jag2, Dll1 and Hes1 became downregulated upon aging dependent on HIF-2α. Inhibition of Notch signaling in wild-type spleen HSCs phenocopied the increased growth of BFU-Es in the Hif-p4h-2gt/gt mice. We conclude that HIFα stabilization can mediate non-erythropoietin-driven extramedullary erythropoiesis in the spleen via altered Notch signaling. Disclosures Myllyharju: FibroGen Inc.: Equity Ownership, Research Funding.
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Books on the topic "2GDT"

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Tso, Bendi, and Marnyi Gyatso. Shépa: The Tibetan Oral Tradition in Choné. Open Book Publishers, 2023.

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Book chapters on the topic "2GDT"

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Li, J. H., and P. Schumacher. "Tailoring Precipitates in Mg-6Zn-2Gd Based Alloy Subjected to High Pressure Torsion." In Magnesium Technology 2013, 351–56. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118663004.ch59.

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Lu, Yiyi, Yuanding Huang, Frank Feyerabend, Regine Willumeit-Römer, Karl Urich Kainer, and Norbert Hort. "In Vitro Corrosion and Cytocompatibility Properties of Mg-2Gd-X(Ag, Ca) Alloys." In Magnesium Technology 2016, 347–51. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-48114-2_67.

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Li, J. H., and P. Schumacher. "Tailoring Precipitates in Mg-6Zn-2Gd Based Alloy Subjected to High Pressure Torsion." In Magnesium Technology 2013, 351–56. Cham: Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-48150-0_59.

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Lu, Yiyi, Yuanding Huang, Frank Feyerabend, Regine Willumeit-Römer, Karl Urich Kainer, and Norbert Hort. "In Vitro Corrosion and Cytocompatibility Properties of Mg-2Gd-X(Ag, Ca) Alloys." In Magnesium Technology 2016, 347–51. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781119274803.ch67.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of [{Cu(salen)}2Gd(H2O)3](ClO4)3·2Cu(salen) 0.5EtNO2." In Magnetic Properties of Paramagnetic Compounds, 5075–76. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-23675-4_4637.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of [{Cu(Me-salen)}2Gd(H2O)3](ClO4)3·2Cu(Me-salen)⋅0.5EtNO2." In Magnetic Properties of Paramagnetic Compounds, 5077–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-23675-4_4638.

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"In the mean direction, y = 0, the first exponential expression gives (exp(-x"2f))b = 1 for b = 0 and all x > 0. Equation (3.8) is reduced to C(x,y,z) = ax‘(f+g) [exp(-dQx"29) + expt-d^'29)] (3.10). The essential behaviour of the transport model in the vicinity of the source can be discussed by the equation (3.10), searching for the maximum concentration in direction of the centerline, dC/dx = 0. From equation (3.11) the distance x > 0 is computable at which maximum concentration occurs: 2gd d, d-d, 9d-d, 3.11). At ground level, z = 0 and dQ = d-j = , xmax becomes." In Odour Prevention and Control of Organic Sludge and Livestock Farming, 121. CRC Press, 1986. http://dx.doi.org/10.1201/9781482286311-44.

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Conference papers on the topic "2GDT"

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Pérez de la Portilla, Marina, José Andrés Somolinos Sánchez, Amable López Piñeiro, Rafael Morales Herrera, and Eva Segura. "Automatización de maniobras para un TEC de 2GdL." In XXXVIII Jornadas de Automática. Universidade da Coruña. Servizo de Publicacións, 2020. http://dx.doi.org/10.17979/spudc.9788497497749.0226.

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