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Tannenbaum, M. J. "Highlights from BNL-RHIC 2011–2013." International Journal of Modern Physics A 29, no. 13 (May 15, 2014): 1430017. http://dx.doi.org/10.1142/s0217751x14300178.
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Highlights from Brookhaven National Laboratory (BNL) and experiments at the BNL Relativistic Heavy Ion Collider (RHIC) are presented for the years 2011–2013. This review is a combination of lectures which discussed the latest results each year at a three year celebration of the 50th anniversary of the International School of Subnuclear Physics in Erice, Sicily, Italy. Since the first collisions in the year 2000, RHIC has provided nucleus–nucleus and polarized proton–proton collisions over a range of nucleon–nucleon center-of-mass energies [Formula: see text] from 7.7 GeV to 510 GeV with nuclei from deuterium to uranium, most often gold. The objective was the discovery of the Quark Gluon Plasma, which was achieved, and the measurement of its properties, which were much different than expected, namely a "perfect fluid" of quarks and gluons with their color charges exposed rather than a gas. Topics including quenching of light and heavy quarks at large transverse momentum, thermal photons, search for a QCD critical point as well as measurements of collective flow, two-particle correlations and J/Ψ suppression are presented. During this period, results from the first and subsequent heavy ion measurements at the Large Hadron Collider (LHC) at CERN became available. These confirmed and extended the RHIC discoveries and have led to ideas for new and improved measurements.
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Nasrin, R. "Aspect Ratio Effect of Vertical Lid Driven Chamber Having a Centered Conducting Solid on Mixed Magnetoconvection." Journal of Scientific Research 3, no. 3 (August 28, 2011): 501–13. http://dx.doi.org/10.3329/jsr.v3i3.7433.
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We study the relativistic equation of spin-1/2 particles under the hyperbolic potential and a Coulomb-like tensor potential. By using the generalized parametric of the Nikiforov-Uvarov method and the pseudo-spin symmetry, we obtain the energy eigenvalues equation and the corresponding unnormalized wave functions. Some numerical results are given, too.Keywords: Dirac equation; Tensor potential; Pseudo-spin symmetry; Nikiforov-Uvarov.© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserveddoi:10.3329/jsr.v3i3.8071 J. Sci. Res. 3 (3), 503-510 (2011)
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Eshghi, M. "Pseudo-spin Symmetry for Relativistic-Hyperbolic Problem and Tensor Potential." Journal of Scientific Research 3, no. 3 (August 28, 2011): 493–500. http://dx.doi.org/10.3329/jsr.v3i3.8071.
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We study the relativistic equation of spin-1/2 particles under the hyperbolic potential and a Coulomb-like tensor potential. By using the generalized parametric of the Nikiforov-Uvarov method and the pseudo-spin symmetry, we obtain the energy eigenvalues equation and the corresponding unnormalized wave functions. Some numerical results are given, too.Keywords: Dirac equation; Tensor potential; Pseudo-spin symmetry; Nikiforov-Uvarov.© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserveddoi:10.3329/jsr.v3i3.8071 J. Sci. Res. 3 (3), 503-510 (2011
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Chudzik, Patryk. "Middle Kingdom tombs from Asasif: work in the 2015/2016 season." Polish Archaeology in the Mediterranean 26, no. 1 (July 9, 2018): 183–96. http://dx.doi.org/10.5604/01.3001.0012.1775.
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In the third season of the Polish Asasif Project at the North Asasif Necropolis in West Thebes archaeological fieldwork concentrated on six of the Middle Kingdom rock-cut tombs: MMA 508/TT 311, MMA 509, MMA 512, MMA 514, MMA 515 and MMA 517/TT 240. The corridors and chambers were cleared and the architecture documented and restored. A surface survey was carried out on the slope. Of greatest interest among the finds are Middle Kingdom stonemason’s tools and cartonnages from the Third Intermediate Period.
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Gil-García, Eugenia, Jussara Gue Martini, and Ana Maria Porcel-Gálvez. "Alcohol consumption and risky sexual practices: the pattern of nursing students from the Spanish University." Revista Latino-Americana de Enfermagem 21, no. 4 (July 2013): 941–47. http://dx.doi.org/10.1590/s0104-11692013000400016.
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OBJECTIVE: to determine the prevalence of substance abuse and unsafe sexual practices and to analyze the relationship between them, in nursing students at the University of Seville. METHOD: quantitative methodological approach with a descriptive cross-sectional design. The population was composed of first year nursing students in the University of Seville, during the academic year 2010-2011 (N=510), with consecutive opportunistic sampling composed of students who attended class on the scheduled day (n=291). RESULTS: a high prevalence of alcohol consumption, and increased likelihood of not using protective measures during sexual practices when alcohol had been consumed, was present. CONCLUSION: these findings are consistent with those obtained in the same population in Brazil, and highlight the need to strengthen in the nursing curriculum, the transverse axis related to the prevention of substance abuse, especially alcohol.
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Zhang, Yunlin, Yan Yin, Xiaohan Liu, Zhiqiang Shi, Longqing Feng, Mingliang Liu, Guangwei Zhu, Zhijun Gong, and Boqiang Qin. "Corrigendum to “Spatial-seasonal dynamics of chromophoric dissolved organic matter in Lake Taihu, a large eutrophic, shallow lake in China” [Organic Geochemistry 42 (2011) 510–519]." Organic Geochemistry 46 (May 2012): 54. http://dx.doi.org/10.1016/j.orggeochem.2012.02.002.
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Rahman, Nafisur, and Habibur Rahman. "Quantitative analysis of perindopril erbumine in pharmaceutical preparations by spectrophotometry via ternary complex formation with Zn(II) and eosin and charge transfer complexation with iodine." Spectroscopy 25, no. 2 (2011): 123–36. http://dx.doi.org/10.1155/2011/106936.
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Two simple, sensitive and accurate spectrophotometric methods have been developed for the analysis of perindopril in pharmaceutical preparations. Method A is based on the formation of ternary complex between zinc(II), eosin and the perindopril, which is extractable with chloroform. The absorption spectrum exhibits a band peaking at 510 nm. Method B is based on the interaction of drug with iodine in dichloromethane resulting in the formation of charge transfer complex which absorbs maximally at 365 nm. Beer's law is obeyed in the concentration range 10–200 μg/ml and 10–180 μg/ml with molar absorptivity of 2.25×103and 3.71×103l/mol·cm for methods A and B, respectively. The detection limits for methods A and B are 0.49 and 0.90 μg/ml, respectively. The optimum experimental conditions for the proposed procedures are investigated. Statistical comparison of the results with the reference method shows excellent agreement and indicates no significant difference between the methods compared in terms of accuracy and precision.
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Chudzik, Patryk. "The tombs of Asasif: archaeological exploration in the 2013/2014 season." Polish Archaeology in the Mediterranean XXIV, no. 1 (February 28, 2016): 239–46. http://dx.doi.org/10.5604/01.3001.0009.9909.
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In the 2013/2014 season, a Polish team from the University of Wrocław started work in the northern part of the Asasif necropolis, near the Temple of Queen Hatshepsut in Deir el-Bahari. An archaeological survey was carried out on the Asasif slope. Cleaning work and documentation were undertaken of the architecture of four private tombs: MMA 509/TT 312, MMA 512, MMA 513/TT 314 and MMA 514, as well as the archaeological finds thereof. The rock-cut tombs belong to a Middle Kingdom necropolis and were all reused in later times, especially in the Third Intermediate Period and Late Period.
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Laverty, Anthony A., Chris Kypridemos, Paraskevi Seferidi, Eszter P. Vamos, Jonathan Pearson-Stuttard, Brendan Collins, Simon Capewell, et al. "Quantifying the impact of the Public Health Responsibility Deal on salt intake, cardiovascular disease and gastric cancer burdens: interrupted time series and microsimulation study." Journal of Epidemiology and Community Health 73, no. 9 (July 18, 2019): 881–87. http://dx.doi.org/10.1136/jech-2018-211749.
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BackgroundIn 2011, England introduced the Public Health Responsibility Deal (RD), a public-private partnership (PPP) which gave greater freedom to the food industry to set and monitor targets for salt intakes. We estimated the impact of the RD on trends in salt intake and associated changes in cardiovascular disease (CVD) and gastric cancer (GCa) incidence, mortality and economic costs in England from 2011–2025.MethodsWe used interrupted time series models with 24 hours' urine sample data and the IMPACTNCD microsimulation model to estimate impacts of changes in salt consumption on CVD and GCa incidence, mortality and economic impacts, as well as equity impacts.ResultsBetween 2003 and 2010 mean salt intake was falling annually by 0.20 grams/day among men and 0.12 g/d among women (P-value for trend both < 0.001). After RD implementation in 2011, annual declines in salt intake slowed statistically significantly to 0.11 g/d among men and 0.07 g/d among women (P-values for differences in trend both P < 0.001). We estimated that the RD has been responsible for approximately 9900 (interquartile quartile range (IQR): 6700 to 13,000) additional cases of CVD and 1500 (IQR: 510 to 2300) additional cases of GCa between 2011 and 2018. If the RD continues unchanged between 2019 and 2025, approximately 26 000 (IQR: 20 000 to 31,000) additional cases of CVD and 3800 (IQR: 2200 to 5300) cases of GCa may occur.InterpretationPublic-private partnerships such as the RD which lack robust and independent target setting, monitoring and enforcement are unlikely to produce optimal health gains.
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Diall, H. G., A. A. Diakite, F. Traore, A. Toure, B. Maiga, I. Traore, K. Sacko, et al. "P-510 – Prevalence de la malnutrition chez les enfants hospitalises dans le service de pediatrie du chu gabriel toure de mai 2011 a avril 2012." Archives de Pédiatrie 22, no. 5 (May 2015): 363. http://dx.doi.org/10.1016/s0929-693x(15)30686-2.
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Roznai, Yaniv. "Dawn Oliver and Carlo Fusaro (eds), How Constitutions Change: A Comparative Study, Oxford: Hart Publishing, 2011, 510 pp, hb £55.00." Modern Law Review 75, no. 5 (September 2012): 945–50. http://dx.doi.org/10.1111/j.1468-2230.2012.00931_3.x.
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Buckley, K., P. Kelly, T. Carnus, B. Kavanagh, E. C. O’Gorman, and B. J. McMahon. "Every partridge counts, successful techniques used in the captive conservation breeding programme for wild grey partridge in Ireland." Animal Biodiversity and Conservation 35, no. 2 (December 2012): 387–93. http://dx.doi.org/10.32800/abc.2012.35.0387.
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Between 1998 and 2001 the last remaining wild grey partridge (Perdix perdix) population in Ireland faced imminent extinction with an estimated spring population of 4–6 pairs, and an autumn population of 22–24 birds. A captive breeding programme began in 2002 with two pairs of grey partridge. In the most successful year in 2010, 39 pairs produced a total of 510 chicks. Average chick survival rate was 65.13%. At 88.9 the highest chick survival rate was achieved in 2011. Chick survival of parent–reared birds in captivity is defined by the number of juveniles surviving at age six weeks: similar to estimations used for wild populations of grey partridge. Family coveys were released in late summer to early autumn. In most instances the entire family cohort was released as one unit. However, in coveys of twenty or above, an average of five parent–reared poults were held back as breeding stock for the following year. In early spring of the following year, birds held back were paired with single males or females trapped from the wild. The techniques we used were traditional and labour intensive but highly effective. We recommend that other grey partridge recovery projects should consider captive breeding using the methods employed in this programme to compliment other game management methods used.
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Remoaldo, Paula, Eduardo Duque, and Cadima Ribeiro. "Los impactos medioambientales del evento “2012 Guimarães Capital Europea de la Cultura” percibidos por la comunidad local." Ambiente y Desarrollo 19, no. 36 (January 1, 2015): 29. http://dx.doi.org/10.11144/javeriana.ayd19-36.eihg.
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Este trabajo presenta los resultados de la evaluación de las percepciones de los impactos medioambientales del evento 2012 Capital Europea de Cultura (ECOC) en la comunidad de Guimarães, Patrimonio de la Humanidad. Los datos se obtuvieron a través de una encuesta autoadministrada de un total de 510 residentes en el municipio de Guimarães, a finales de 2011. Los resultados primarios indican que los residentes reconocieron que el acontecimiento aportó beneficios a la ciudad, pero también impactos negativos. Los impactos percibidos por los residentes fueron clasificados como socioculturales, económicos y medioambientales. De todos ellos, los impactos medioambientales negativos fueron los que más repercutieron en el municipio.
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Albuquerque, Daiane C. K., Simone M. Scheffer-Basso, Pedro A. V. Escosteguy, Karen D. Brustolin-Golin, Valdirene Zabot, and Mario Miranda. "Residual effect of pig slurry on common carpet grass pasture." Revista Brasileira de Engenharia Agrícola e Ambiental 21, no. 6 (June 2017): 374–78. http://dx.doi.org/10.1590/1807-1929/agriambi.v21n6p374-378.
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ABSTRACT This study investigated the residual effects of pig slurry (PS) applied to common carpet grass pasture (Axonopus affinis) for two years (September 2008-March 2010) on dry matter yield and forage-nitrogen uptake from October 2010-May 2011. A field experiment was conducted in a randomized complete block design with four replications. The treatments were 102, 204, 306, 408, and 510 m3 ha-1 pig slurry applied for two years; one mineral nitrogen rate (1,250 kg ha-1 ammonium nitrate) for two years; and no nitrogen fertilization (control). The pasture was cut at intervals of 48, 34, 43 and 69 days, which corresponded to 266, 300, 343, and 412 days after the last fertilizer application, respectively. Dry matter yield increased by 398 kg ha-1 for each 100 m3 of PS applied, the equivalent of 317 and 564 kg ha-1 for each 100 kg ha-1 of inorganic and organic N applied, respectively. The residual effect of PS on dry matter yield and forage-nitrogen uptake ranged from 11-45% and 8-40%, respectively, indicating a gradual release and availability of N in PS, which can help reduce the amounts of nitrogen applied to pasture.
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de Cal, Massimo, Mikko Haapio, Dinna N. Cruz, Paolo Lentini, Andrew A. House, Ilona Bobek, Grazia M. Virzì, et al. "B-Type Natriuretic Peptide in the Critically Ill with Acute Kidney Injury." International Journal of Nephrology 2011 (2011): 1–6. http://dx.doi.org/10.4061/2011/951629.
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Introduction. Acute kidney injury (AKI) is common in the intensive care unit (ICU) and associated with poor outcome. Plasma B-type natriuretic peptide (BNP) is a biomarker related to myocardial overload, and is elevated in some ICU patients. There is a high prevalence of both cardiac and renal dysfunction in ICU patients.Aims. To investigate whether plasma BNP levels in the first 48 hours were associated with AKI in ICU patients.Methods. We studied a cohort of 34 consecutive ICU patients. Primary outcome was presence of AKI on presentation, or during ICU stay.Results. For patients with AKI on presentation, BNP was statistically higher at 24 and 48 hours than No-AKI patients (865 versus 148 pg/mL; 1380 versus 131 pg/mL). For patients developing AKI during 48 hours, BNP was statistically higher at 0, 24 and 48 hours than No-AKI patients (510 versus 197 pg/mL; 552 versus 124 pg/mL; 949 versus 104 pg/mL).Conclusion. Critically ill patients with AKI on presentation or during ICU stay have higher levels of the cardiac biomarker BNP relative to No-AKI patients. Elevated levels of plasma BNP may help identify patients with elevated risk of AKI in the ICU setting. The mechanism for this cardiorenal connection requires further investigation.
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ZIEHM, D., S. RETTENBACHER-RIEFLER, L. KREIENBROCK, A. CAMPE, M. PULZ, and J. DREESMAN. "Risk factors associated with sporadic salmonellosis in children: a case-control study in Lower Saxony, Germany, 2008–2011." Epidemiology and Infection 143, no. 4 (June 2, 2014): 687–94. http://dx.doi.org/10.1017/s095026881400140x.
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SUMMARYWe conducted a case-control study based on 884 laboratory-confirmed sporadicSalmonellacases reported to the German infectious disease notification system. For controls, we recruited 510 rotavirus cases via the same system. Univariable and multivariable logistic regression analyses were performed separately for children aged 0–3 years and 4–14 years. In both age groups, the highest odds ratios (OR) were found for raw ground pork consumption [0–3 years: OR 8·6, 95% confidence interval (CI) 2·4–30·8; 4–14 years: OR 4·5, 95% CI 1·1–19]. Further risk factors were exposure to animals (OR 1·6, 95% CI 1·1–2·1), consumption of poultry (OR 1·5, 95% CI 1·1–2·1), food items containing eggs (OR 1·5, 95% CI 1·1–2) and black pepper (OR 1·7, 95% CI 1·1–3·5) in children aged 0–3 years, and consumption of uncooked pork sausage (OR 3·6, 95% CI 1·4–9·3) in children aged 4–14 years. This study highlights the significance of raw pork products (‘Mett’ in German) as risk factors for sporadic salmonellosis in children in Germany.
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Khalef Al Fatlawy, Yaaroub Faleh, Faiza Kadhim, and Beadaa Abdalqader Mahdii. "Evaluation of the Drinking water in some Hospitals in Baghdad." Bionatura 8, no. 4 (December 15, 2023): 1–16. http://dx.doi.org/10.21931/rb/2023.08.04.52.
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Due to the significance of hospital drinking water, a study was done to assess the water in three hospitals in Baghdad (Al-Yarmouk Teaching Hospital, Ibn Sina Hospital, and Ibn-Al-Nafis Hospital) for its nature and quality, compare it to other hospitals in terms of its physical, chemical, and bacterial specifications, and compare it to international standards. According to Iraqi standards from 2009 and WHO standards from 2011, Chemical factors were measured, which included pH, Total Dissolved Solids (TDS), and Calcium Ion (Ca+2). Reported readings are all within acceptable ranges for drinking water. In contrast, turbidity, total hardness (T.H.), chlorides (Cl-), magnesium (Mg+2), the number of aerobic plates (APC), total coliform (T.C.), fecal coliform (F.C.), and fecal streptococcus (F.S.) which maximum values were (8.7 NTU, 690 mg-1, 510 mg-1, 231.1 mg/l, 38 cfu/ml, 20 cfu /100ml, 16 cfu /100ml, and 16 cfu /100ml) respectively. These values were higher than the permissible level recommended by the Iraqi standard (2009) and WHO standard (2011) for drinking water for all months and some months. Keywords: Drinking/ Water/ Hospitals/ Baghdad.
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El-Didamony, Akram M., and Eman A. H. Erfan. "Spectrophotometric determination ofβ-blocker drugs by oxidation with bromate–bromide mixture and its analytical application to pharmaceutical preparations." Spectroscopy 25, no. 6 (2011): 303–15. http://dx.doi.org/10.1155/2011/541962.
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Three visible spectrophotometric methods (A–C) were developed for the analysis of someβ-blocker drugs, namely atenolol (ATE) and timolol (TIM) based on their reactivity with bromine, generated in situ by the action of hydrochloric acid on bromate–bromide mixture. The determination of residual bromine is based on its ability to bleach the indigo carmine dye and measuring the absorbance at 610 nm (method A). Methods B and C involve treating the unreacted bromine with a measured excess of iron (II), the remaining iron (II) is complexed with 1,10-phenanthroline (method B) or with 2,2'-bipyridyl (method C) and measuring the increase in absorbance at 510 and 522 nm, respectively. In all the methods, the amount of bromine reacted corresponding to the drug content. Regression analysis of Beer's plot showed good correlation in the concentration ranges of 0.4–16.4, 0.8–10.4 and 0.4–12.8 µg/ml using methods A–C, respectively, for ATE and 14–38, 12–32 and 14–38 µg/ml using methods A–C, respectively, for TIM. The optimum reaction conditions and other analytical parameters are evaluated. No interference was observed from the additives and the applicability of the methods was tested by analyzing the pharmaceutical preparations containing the investigated drugs. Statistical comparison of the results with those of official methods shows excellent agreement and indicates no significant difference in precision.
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Rosero, Doris A., Nelson Naranjo-Diaz, Natalí Alvarez, Astrid V. Cienfuegos, Carolina Torres, Shirley Luckhart, and Margarita M. Correa. "Colombian Anopheles triannulatus (Diptera: Culicidae) Naturally Infected with Plasmodium spp." ISRN Parasitology 2013 (October 8, 2013): 1–10. http://dx.doi.org/10.5402/2013/927453.
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The role of Anopheles triannulatus as a local vector has not yet been defined for malaria-endemic regions of Colombia. Therefore, the aim of this work was to detect An. triannulatus naturally infected with Plasmodium spp., as an approximation to determining its importance as malaria vector in the country. A total of 510 An. triannulatus were collected in six malaria-endemic localities of NW and SE Colombia from January 2009 to March 2011. In the NW, two specimens were naturally infected; one with Plasmodium vivax VK247, collected biting on humans and the other with Plasmodium falciparum, collected resting on cattle. In the SE, two specimens were positive for P. falciparum. Although these results show An. triannulatus naturally infected with Plasmodium, further studies are recommended to demonstrate the epidemiological importance of this species in malaria-endemic regions of Colombia.
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Pchelkin, Victor, and Yuri Bezborodov. "Water balance in the aeration zone at the irrigation of red beets in the Russian Non-Chernozem area." E3S Web of Conferences 497 (2024): 03014. http://dx.doi.org/10.1051/e3sconf/202449703014.
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Basing on experimental data, we obtained the correlation results between the water balance elements in the aeration zone and the calculated layer at the irrigation of red beets on sod-podzolic soils. We provided a methodology to conduct research on experimental plots and in lysimeters. The water balances for the aeration zone in the lysimeters and for the calculated soil layer on the experimental plots are presented. It is shown that the amount of precipitation during the growing season 2010–2011 (97, 195 mm) and the sum of average daily air humidity deficits (12.1, 9.6 mb) influence water consumption (510, 498 mm) and irrigation norms (414, 318 mm). Soil moisture at the conditions of sod-podzolic soil of watershed territories in Moscow Oblast at sprinkler irrigation has a significant impact on all the components of the water balance, especially on the irrigation norm and water consumption of red beets. We stated the relation between the irrigation norm for red beets and the moisture content of the calculated layer of sod-podzolic soil. The correlation coefficient of the considered values is 0,996+0,031. A relation between the water consumption of red beets and the moisture content in the watershed sod-podzolic soil was obtained. The correlation coefficient of the considered values is 0,991+0,053.
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Stec, Krystyna. "Focal Mechanisms of Mine-Induced Seismic Events an Explanation of Geomechanical Processes in the Area of Longwall 6, Seam 510 In Hard Coal Mine “Bobrek-Centrum” / Mechanizm Ognisk Indukowanych Wstrząsów Górniczych Wyjaśnieniem Procesów Geomechanicznych W Rejonie Ściany 6, Pokład 510 W Kopalni „Bobrek-Centrum”." Archives of Mining Sciences 57, no. 4 (December 1, 2012): 871–86. http://dx.doi.org/10.2478/v10267-012-0057-7.
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Abstract Exploitation in a coal mine “Bobrek-Centrum” of the longwall 6 in seam 510 has led to the occurrence of very high seismic activity. From January 2011 to June 2012 took place almost 3500 tremors with the energy of 102-104 J and 95 tremors of energy more than to 105 J. In an attempt to identify the character of that seismicity, calculations of focal mechanism parameters were carried out, and according to them local stress field was determined. Three periods of exploitation of longwall 6 were distinguished which vary in type of focal mechanism. Tremors, which occurred in exploitation periods I and III were characterized by normal slip mechanism, occurred due to domination of vertical principal stresses σ1, horizontal intermediate stresses σ2 and minimal ones σ3. Such stress arrangement characterizes local state of rock mass behaviour as a result of cracking and collapse of sandstone, tremor-generating strata during advancing exploitation. In exploitation period II, of non-shearing mechanism of foci occurred. That was the period of change of longwall run from the NE-SW direction to E-W direction, that is the period of so called “slanting” of exploitation front. It can be presumed that this type of tremor mechanism could have occurred due to a sudden coal bed load by superimposed roof strata, which may have led to extreme load conditions and to a dynamic disintegration of seam part. It was confirmed by geomechanical calculations, which indicated that in the region of rockburst existence on 19.07.2011, layers which were located above and under seam 510 in area of longwall no. 6 were strongly deformed locally causing compression of certain parts of seam.
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Xu, Qinghua. "Measurement of Longitudinal Single-Spin Asymmetry for W± Production in Polarized Proton+Proton Collisions at STAR." Journal of Physics: Conference Series 1643, no. 1 (December 1, 2020): 012197. http://dx.doi.org/10.1088/1742-6596/1643/1/012197.
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Abstract The contribution from the sea quark polarization to the nucleon spin is an important piece for the complete understanding of the nucleon spin structure. The production of W ± bosons in longitudinally polarized p+p collisions at the RHIC collider at Brookhaven National Laboratory provides a unique probe of the sea quark polarization, through the parity-violating single-spin asymmetry, AL . At the STAR experiment, the W bosons that decay through the W → ev channel at mid-rapidity (|η <1.3) can be effectively determined with the Electromagnetic Calorimeters and Time Projection Chamber. The STAR measurements of AL for W boson from datasets taken in 2011 and 2012 at s =510 GeV have been included in the global analysis of polarized parton distribution functions, and provided significant constraints on the helicity distribution functions of u ¯ and d ¯ quarks. The final AL results from 2013 STAR data sample are reported, which is about three times larger than the total integrated luminosity of previous years. The combined results of AL for 2011-2013 data are also given. A flavor asymmetry of light sea quark helicity distribution, Δ u ¯ ( x ) − Δ d ¯ ( x ) > 0 , is confirmed from a re-weighting of global analysis NNPDFpol1.1 after including the new AL results. In addition, results on the double-spin asymmetries ALL for W ±, and AL for Z/γ* production are also reported.
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Bambini, Laura, James R. Daley, Calvin Fenton, Gerard A. L. Gray, Glenford James, Lloyd Martin, Stephen Mendes, and Steffen Oppel. "Current population status of four endemic Caribbean forest birds in Montserrat." Journal of Caribbean Ornithology 30, no. 1 (December 16, 2017): 2–9. http://dx.doi.org/10.55431/jco.2017.30(1).2-9.
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Abstract: Deforestation is a major cause of biodiversity loss across the world, but in the Caribbean region the fate of many forest species is poorly known despite ongoing forest loss. Bird populations in Montserrat were affected by the loss of more than 50% of the island’s forest cover since 1995 when the Soufrière Hills Volcano started erupting. Today, Montserrat’s bird populations appear to be stable but little is known about the status of many of the species. We report on the current population trajectories of four endemic Caribbean forest birds found in Montserrat: Bridled Quail-Dove (Geotrygon mystacea), Forest Thrush (Turdus lherminieri), Brown Trembler (Cinclocerthia ruficauda), and Montserrat Oriole (Icterus oberi). We estimated abundance from repeated count surveys around 67 sampling points during 2011–2016 using binomial mixture models and conclude that the Forest Thrush is the most common species (1,174 individuals in 2016; 95% credible interval: 624–2,178), with Bridled Quail-Dove (411; 250–853), Montserrat Oriole (323; 221–510), and Brown Trembler (246; 150–541) less common. Low precision in the estimates limits inference about population trends, but the Montserrat Oriole appears to have increased between 2011 and 2016 (trend estimate = 0.161; 0.032–0.298). We recommend that the current monitoring is continued on an annual basis to understand population trajectories of forest birds. Continued protection of the remaining forests is critical to maintain stable populations of the forest bird species in Montserrat.
Keywords: forest birds, Montserrat, population trends
Resumen: Estado poblacional actual de cuatro especies de aves de bosque endémicas del Caribe en Montserrat—La deforestación es la causa principal de pérdida de la biodiversidad en todo el mundo; pero en la región del Caribe el destino de muchas especies forestales es poco conocido pese a la pérdida continua de bosques. Las poblaciones de aves en Montserrat fueron afectadas por la pérdida de más del 50% de la cobertura boscosa de la isla desde que en 1995 entrara en erupción el volcán Soufrière Hills. Actualmente, las poblaciones de aves de Montserrat parecen estar estables, aunque se conoce poco sobre el estado de muchas de las especies. Ampliamos la información existente sobre los estados poblacionales de cuatro especies de aves de bosque endémicas del Caribe que se encuentran en Montserrat: Geotrygon mystacea, Turdus lherminieri, Cinclocerthia ruficauda y Icterus oberi. La abundancia fue estimada a partir de conteos repetidos en 67 puntos de muestreo durante el periodo 2011–2016 usando modelos binomiales mixtos y concluimos que Turdus lherminieri es la especie más común (1.174 individuos en 2016, intervalos de confianza del 95%: 624–2.178), en cambio, Geotrygon mystacea (411; 250–853), Icterus oberi (323; 221–510) y Cinclocerthia ruficauda (246; 150–541) fueron mucho menos comunes. La baja precisión en las estimaciones limita las inferencias sobre las tendencias poblacionales, pero Icterus oberi parece haber aumentado entre el 2011 y el 2016 (estimación de tendencia = 0,161; 0,032–0,298). Recomendamos que el monitoreo actual se continúe anualmente para entender las tendencias poblaciones de las aves de bosque. La protección continua de los bosques remanentes es crucial para mantener estables las poblaciones de estas aves en Montserrat.
Palabras: clave aves de bosque, Montserrat, tendencias poblacionales
Résumé: État actuel de la population de quatre espèces d’oiseaux endémiques des forêts caribéennes de Montserrat—La déforestation est une cause majeure de la perte de biodiversité à travers le monde, mais dans la région Caraïbe, le sort de nombreuses espèces forestières est peu connu malgré la disparition progressive des forêts. Les populations d’oiseaux de Montserrat ont été affectées par la perte de plus de 50% de la couverture forestière de l’île depuis 1995, lorsque le volcan de la Soufrière est entré en éruption. Aujourd’hui, les populations d’oiseaux de Montserrat semblent stables, mais l’état de conservation de nombreuses espèces est peu connu. Nous présentons les trajectoires actuelles des populations de quatre oiseaux endémiques des forêts caribéennes de Montserrat : la Colombe à croissants (Geotrygon mystacea), la Grive à pieds jaunes (Turdus lherminieri), le Trembleur brun (Cinclocerthia ruficauda), et l’Oriole de Montserrat (Icterus oberi). Nous avons estimé leur abondance en utilisant un modèle binomial mixte, à partir de comptages répétés de 2011 à 2016 autour de 67 points d’échantillonnage, et nous concluons que la Grive à pieds jaunes est l’espèce la plus commune (1.174 individus en 2016, intervalle de confiance à 95% : 624-2.178), suivi de la Colombe à croissants (411 ; 250-853), de l’Oriole de Montserrat (323 ; 221-510) et du Trembleur brun (246 ; 150-541) l’espèce la moins fréquente. La faible précision des valeurs estimées limite la capacité à prédire les tendances des populations, mais l’Oriole de Montserrat semble avoir augmenté entre 2011 et 2016 (estimation de la tendance = 0,161 ; 0,032-0,298). Nous recommandons que le suivi actuel se poursuive sur une base annuelle afin de comprendre l’évolution des populations d’oiseaux forestiers. La protection continue des forêts restantes est essentielle au maintien de la stabilité de l’avifaune forestière de Montserrat.
Mots clés: Montserrat, oiseaux forestiers, tendances démographiques
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Healey, Dione M., David J. Marks, and Jeffrey M. Halperin. "Examining the Interplay Among Negative Emotionality, Cognitive Functioning, and Attention Deficit/Hyperactivity Disorder Symptom Severity." Journal of the International Neuropsychological Society 17, no. 3 (April 5, 2011): 502–10. http://dx.doi.org/10.1017/s1355617711000294.
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AbstractCognition and emotion, traditionally thought of as largely distinct, have recently begun to be conceptualized as dynamically linked processes that interact to influence functioning. This study investigated the moderating effects of cognitive functioning on the relationship between negative emotionality and attention deficit/hyperactivity disorder (ADHD) symptom severity. A total of 216 (140 hyperactive/inattentive; 76 typically developing) preschoolers aged 3–4 years were administered a neuropsychological test battery (i.e., NEPSY). To avoid method bias, child negative emotionality was rated by teachers (Temperament Assessment Battery for Children-Revised), and parents rated symptom severity on the ADHD Rating Scale (ADHD-RS-IV). Hierarchical Linear Regression analyses revealed that both negative emotionality and Perceptual-Motor & Executive Functions accounted for significant unique variance in ADHD symptom severity. Significant interactions indicated that when negative emotionality is low, but not high, neuropsychological functioning accounts for significant variability in ADHD symptoms, with lower functioning predicting more symptoms. Emotional and neuropsychological functioning, both individually and in combination, play a significant role in the expression of ADHD symptom severity. (JINS, 2011, 17, 502–510)
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Surikov, I. E. "On Athens` Coinage at the End of the Archaic Period (A Historical Context of Transition from Wappenmünzen to “Owls”)." Ancient World and Archaeology 19 (December 18, 2019): 12–18. http://dx.doi.org/10.18500/0320-961x-2019-19-12-18.
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The article deals with the fate of the first Athenian coinage (coins known under the conventional name of Wappenmünzen) at its latest stage, when there took place a transition to coins of principally new type (“head of Athena – owl”, ΑΘΕ), which later became so glorious. The author connects the transition mentioned with the fall of tyranny in 510 BC and dates a little earlier beginning of Wappenmünzen tetradrachms issuing to 514–513 BC, while correlating it with such events as the tyrants Hippias’ clash with aristocrats and hardening of his policies. In the same context he tries to interpret the so-called Hippias’ monetary reform, which is mentioned vaguely in Pseudo-Aristotle’s Economics.
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Koirala, Naba Raj, Rajesh Yadav, Ajay Kumar Das, Jwalanta Poudel, and Santosh Kumar Bhagat. "A study of socio-demographic and diagnostic profile of patients attending the psychiatric out-patient department of Nobel Medical College Biratnagar." Journal of Nobel Medical College 1, no. 2 (December 29, 2012): 45–49. http://dx.doi.org/10.3126/jonmc.v1i2.7299.
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Study on prevalence of psychiatric disorders in Eastern part of Nepal, is relatively understudied subject in Nepal. The present study is undertaken with the aim to study the socio-demographic characteristics and diagnostic profile of patients attending the psychiatry OPD of Nobel Medical College, that provides both outpatient and inpatient services to psychiatric patients residing in eastern part of Nepal and nearby Indian villages. It was a retrospective study where all consecutive patients attending the Psychiatry OPD from 1st May 2011 to 30th April 2012 and fulfilling the diagnostic criteria for Category F of ICD-101 were included in the study. Amongst the total number of 637 patients, cases with Epilepsy (N=44), Headache (N=53), other medical disorders (N=13) and incomplete case record (N=17) were excluded, and the final sample size was comprised of 510 cases (males=214 and females=296). Maximum numbers of patients were in the age-group 16-40 years (N=238, 47%) and were married (N=416, 79.04%). Most of the patients suffered from Neurotic stress-related and somatoform disorders (N=214, 41.96%), followed by Mood (N=168, 32.94%) and Schizophrenia, schizotypal and related disorders (N=56, 10.98%).DOI: http://dx.doi.org/10.3126/jonmc.v1i2.7299 Journal of Nobel Medical College (2012), Vol.1 No.2 p.45-49
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Mansour, Asem, Amal Al-Omari, and Iyad Sultan. "Burden of Cancer Among Syrian Refugees in Jordan." Journal of Global Oncology, no. 4 (December 2018): 1–6. http://dx.doi.org/10.1200/jgo.18.00132.
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The Syrian crisis, which started in 2011, has had a profound impact on the entire region. Jordan, with its limited resources, now has the second highest ratio of refugees to inhabitants in the world (89 to 1,000). The actual number of Syrians in Jordan is hotly contested: more than 630,776 refugees registered in November 2015 compared with 1,265,514 reported by the national census conducted at the same time. Although the numbers are slowly but steadily increasing, the number of patients with cancer who were registered by the Jordan Cancer Registry peaked in 2013 at 510 patients reported and subsequently slumped downward, which coincided with changes in funding as a result of the increasing strains on the Ministry of Health. Older individuals, women, and patients with advanced diseases were less likely to be registered. These findings overlap with data obtained from the authors’ own center registry. Using age- and sex-specific population-based incidence rates, we estimated that 869 Syrians are diagnosed with cancer in Jordan annually. Using diagnosis-specific cost records of the King Hussein Cancer Foundation, we estimated that the cost of their treatments is 15.6 million Jordan dinars (US$22.1 million).
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Um, J., and G. M. McFarquhar. "Dependence of the single-scattering properties of small ice crystals on idealized shape models." Atmospheric Chemistry and Physics 11, no. 7 (April 4, 2011): 3159–71. http://dx.doi.org/10.5194/acp-11-3159-2011.
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Abstract. The projections of small ice crystals (with maximum dimension <50 μm) appear quasi-circular when imaged by probes on aircraft flying through cloud. Therefore, idealized models constructed to calculate their single-scattering properties have included quasi-spherical models such as Chebyshev particles, Gaussian random spheres, and droxtals. Recently, an ice analogue grown from sodium fluorosilicate solution on a glass substrate, with several columns emanating from a common center of mass, was shown to be quasi-circular when imaged by state-of-the-art cloud probes. In this study, a new idealized model, called the budding Bucky ball (3B) that resembles the shape of the small ice analogue is developed. The corresponding single-scattering properties (scattering phase function P11 and asymmetry parameter g) are computed by a ray-tracing code. Compared with previously used models, 3B scatters less light in the forward and more light in the lateral and backward directions. The Chebyshev particles and Gaussian random spheres show smooth and featureless P11, whereas droxtals and 3Bs, which have a faceted structure, show several peaks in P11 associated with angles of minimum deviation. Overall, the difference in the forward (lateral; backward) scattering between models are up to 22% (994%; 132%), 20% (510%; 101%), and 16% (146%; 156%) for small ice crystals with respective area ratios of 0.85, 0.77, and 0.69. The g for different models varies by up to 25%, 23%, and 19% for particles with area ratios of 0.85, 0.77, and 0.69, respectively. Because the single-scattering properties of small ice crystals depend both on the choice of the idealized model and the area ratios used to characterize the small ice crystals, higher resolution observations of small ice crystals or direct observations of their single-scattering properties are required.
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Hatakeyama, Shingo, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, and Chikara Ohyama. "The impact of contrast enhancement reduction on tumor response in patients with advanced renal cell carcinoma that treated with presurgical targeting therapy." Journal of Clinical Oncology 34, no. 2_suppl (January 10, 2016): 510. http://dx.doi.org/10.1200/jco.2016.34.2_suppl.510.
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510 Background: RECIST is a standard tool for tumor response assessment. However, evaluation for targeted therapy by RECIST is insensitive because tumors often showed a modest change in size despite of significant necrosis. Therefore, we investigated an impact of contrast enhancement reduction for tumor shrinkage in RCC patients with presurgical targeting therapy. Methods: From March 2011 to July 2015, 17 patients (18 tumors) with RCC who underwent presurgical targeting therapy were included. Indications for presurgical targeting therapy were cT3-4, bilateral tumors, poor performance status, or small distant metastasis. Contrast enhancement reduction was evaluated by contrast medium enhanced area (CMEA) before and after targeting therapy. CMEA measurements were performed by OsiriX and Adobe Photoshop. Eighteen tumors were evaluated by RECIST and CMEA. Differences between two methods were compared. Results: Median age and followup after initiation of targeted therapy were 68 years old and 15.3 months. IVC thrombus and small distant metastasis existed in seven (41%) and five (29%) patents, respectively. Fifteen patients (88%) received TKI based (sunitinib and/or axitinib), and three patients (12%) received mTOR inhibitor based (everolimus or temsirolimus) presurgical therapy. The median treatment period of presurgical targeted therapy was 3.3 months. Median tumor responses in RECIST and CMEA were 10.5% and 49.0%, that was significantly correlated by liner regression analysis (P = 0.002). TKI based presurgical therapy showed significant tumor reduction in CMEA than RECIST (P = 0.0062). In addition, tumor reduction rate was significantly higher in TKI based presurgical therapy than mTOR inhibitor (P = 0.014). No patient experienced tumor recurrence. Conclusions: Contrast enhancement reduction might be useful tool for tumor shrinkage in patients with RCC who underwent presurgical targeting therapy.
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Dajnowicz-Piesiecka, Diana. "Przestępczość przeciwko wyborom i referendum w Polsce w latach 1999–2019." Przegląd Sejmowy 2(169) (2022): 9–38. http://dx.doi.org/10.31268/ps.2022.97.
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The article deals with legal aspects of crime against elections and referendum and its selected criminal symptoms. The legislator has defined crimes of this kind in two legal acts: the Criminal Code of 1997 (Articles 248–251) and the Electoral Code of 2011 (Articles 497–497a, 500–510 and 513c). Crimes against elections and referendum include, among others, violation of the freedom to vote, electoral bribery, violation of the secrecy of the ballot, collection of signatures of support in the form of pressure, in unauthorised places and for advantage, possession of the ballot outside the polling station or lack of openness and transparency of the financial management of the electoral committee. Although the Penal Code contains fewer offenses against elections than the Election Code, the behaviours included therein were committed more often (they constituted 3/4 of election crimes in Poland). The stated election crimes have intensified in recent years and are characterised by an upward trend. Elections are therefore for some a realisation of fundamental civic rights, and for others, unfortunately, a field for abuse to achieve electoral success (one’s own or that of a political favorite). The research results presented in this article justify the need to deepen scientific research, especially on criminogenic factors of electoral crime.
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Benito, G., B. A. Botero, V. R. Thorndycraft, M. Rico, Y. Sánchez-Moya, A. Sopeña, M. J. Machado, and O. Dahan. "Rainfall-runoff modelling and palaeoflood hydrology applied to reconstruct centennial scale records of flooding and aquifer recharge in ungauged ephemeral rivers." Hydrology and Earth System Sciences 15, no. 4 (April 8, 2011): 1185–96. http://dx.doi.org/10.5194/hess-15-1185-2011.
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Abstract. In this study we propose a multi-source data approach for quantifying long-term flooding and aquifer recharge in ungauged ephemeral rivers. The methodology is applied to the Buffels River, at 9000 km2 the largest ephemeral river in Namaqualand (NW South Africa), a region with scarce stream flow records limiting research investigating hydrological response to global change. Daily discharge and annual flood series (1965–2006) were estimated from a distributed rainfall-runoff hydrological model (TETIS) using rainfall gauge records located within the catchment. The model was calibrated and validated with data collected during a two year monitoring programme (2005–2006) at two stream flow stations, one each in the upper and lower reaches of the catchment. In addition to the modelled flow records, non-systematic flood data were reconstructed using both sedimentary and documentary evidence. The palaeoflood record identified at least 25 large floods during the last 700 yr; with the largest floods reaching a minimum discharge of 255 m3 s−1 (450 yr return period) in the upper basin, and 510 m3 s−1 (100 yr return period) in the lower catchment. Since AD 1925, the flood hydrology of the Buffels River has been characterised by a decrease in the magnitude and frequency of extreme floods, with palaeoflood discharges (period 1500–1921) five times greater than the largest modelled floods during the period 1965–2006. Large floods generated the highest hydrograph volumes, however their contribution to aquifer recharge is limited as this depends on other factors such as flood duration and storage capacity of the unsaturated zone prior to the flood. Floods having average return intervals of 5–10 yr (120–140 m3 s−1) and flowing for 12 days are able to fully saturate the Spektakel aquifer in the lower Buffels River basin. Alluvial aquifer storage capacity limiting potential recharge by the largest floods is a common problem in arid environments, with the largest infiltration volumes favoured by increasing depth to groundwater levels.
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Christensen, Andre F., Hailong He, Miles F. Dyck, E. Lenore Turner, David S. Chanasyk, M. Anne Naeth, and Connie Nichol. "In situ measurement of snowmelt infiltration under various topsoil cap thicknesses on a reclaimed site." Canadian Journal of Soil Science 93, no. 4 (September 2013): 497–510. http://dx.doi.org/10.4141/cjss2012-048.
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Christensen, A. F., He, H., Dyck, M. F., Turner, L., Chanasyk, D. S., Naeth, M. A. and Nichol, C. 2013. In situ measurement of snowmelt infiltration under various topsoil cap thicknesses on a reclaimed site. Can. J. Soil Sci. 93: 497–510. Understanding the soil and climatic conditions affecting the partitioning of snowmelt to runoff and infiltration during spring snow ablation is a requisite for water resources management and environmental risk assessment in cold semi-arid regions. Soil freezing and thawing processes, snowmelt runoff or infiltration into seasonally frozen soils have been documented for natural, agricultural or forested systems but rarely studied in severely disturbed systems such as reclaimed lands. The objective of this study was to quantify the snowmelt infiltration/runoff on phosphogypsum (PG) tailings piles capped with varying thicknesses of topsoil (0.15, 0.3, and 0.46 m) at a phosphate fertilizer production facility in Alberta. There are currently no environmental regulations specifying topsoil capping thickness or characteristics for these types of tailings piles. Generally, the function of the topsoil cap is to facilitate plant growth and minimize the amount of drainage into the underlying PG. Experimental plots were established in 2006 to better understand the vegetation and water dynamics in this reconstructed soil. In 2011, time domain reflectometry (TDR) probes and temperature sensors were installed at various depths for continuous, simultaneous, and automated measurement of composite dielectric permittivity (ɛeff) and soil temperature, respectively. An on-site meteorological station was used to record routine weather data. Liquid water and ice content were calculated with TDR-measured effective permittivity (ɛeff) and a composite dielectric mixing model. Spatial and temporal change of total water content (ice and liquid) revealed that snowmelt infiltration into the topsoil cap increased with increasing topsoil depth and net soil water flux from the topsoil cap into the PG material was positive during the snowmelt period in the spring of 2011. Given the objective of the capping soil is to reduce drainage of water into the PG material it is recognized that a capping soil with a higher water-holding capacity could reduce the amount of meteoric water entering the tailings.
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S. S. SINGH. "Effect of elevated CO2 on growth and yield of rice crop in open top chamber in Sub humid climate of eastern India." Journal of Agrometeorology 15, no. 1 (June 1, 2013): 1–10. http://dx.doi.org/10.54386/jam.v15i1.1429.
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This study was conducted during 2011 and 2012 at the experimental farm of ICAR Research Complex for Eastern Region, Patna, India in Open top chamber (OTC) as well as in open field condition. Four rice genotypes (Local/Indigenous:Rajshree, promising HYV of state: Rajendra Bhagwati, promising HYV of eastern region: Swarna sub 1 and ruling variety in state: MTU 7029) were used for the study. The1 hr averages of CO2 in the elevated CO2 OTC ranged between 455 and 510 ppm with a mean of 482 ppm and a standard deviation (S.D.) of 12.7ppm. LAI of the elevated CO2 treatment was significantly ( p<0.05) greater than the control OTC and open field at all times in both kharif seasons. The higher grain yields in rice crops under elevated CO2 were primarily due to their greater biomass production capacity and not due to a greater fraction of total biomass being partitioned to grains. The greater biomass under elevated CO2 was brought about by an increase in RUE, during both pre- and post-anthesis periods. In both the years, rice growing under elevated CO2 had significantly greater grain numbers and grain yields than under ambient CO2 and open field conditions, which did not differ significantly. The percentage of filled grains also was significantly greater in the elevated treatment.
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Shrestha, Srishti, Xiaoqian Zhu, Vidyulata Kamath, Kevin J. Sullivan, Jennifer A. Deal, A. Richey Sharrett, Andrea L. C. Schneider, et al. "Factors Associated with Poor Olfaction and Olfactory Decline in Older Adults in the ARIC Neurocognitive Study." Nutrients 15, no. 16 (August 19, 2023): 3641. http://dx.doi.org/10.3390/nu15163641.
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Olfactory function has significant implications for human health, but few risk factors for olfactory decline have been identified. We examined the factors associated with olfactory status and decline over five years in the Atherosclerosis Risk in Communities (ARIC) Neurocognitive Study. A 12-item odor identification test was used to assess olfaction in 6053 participants in 2011–2013 (ARIC visit 5, mean age: 75.6, 41% male, 23% Black race) and in 3235 participants in 2016–2017 (visit 6). We used Poisson regression models to examine cross-sectional associations of a range of potential factors with the total odor identification errors (mean errors: 2.8 ± 2.4) in visit 5 participants. We used mixed-effect Poisson regression to examine associations with olfactory decline between visits 5 and 6. We also examined associations with visit 5 anosmia prevalence (847 cases, 14%) and incident anosmia between the two visits (510 cases, 16%) using Poisson models. Older age, male sex, lower education, Black race, APOE ε4 alleles, and diabetes were associated with higher odor identification errors and higher anosmia prevalence, and greater physical activity and hypertension with better olfaction. Age, male sex, lower education, Black race, APOE ε4 allele, and vitamin B12 levels were associated with incident anosmia over 5 years. Older age was associated with faster olfactory decline. Future studies with longer follow-ups are warranted.
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Meyers, Michael, Erik Erdal, Christpoher Khan, Amy McKee, and Betsy Lahue. "Efficiency Outcomes Associated with Increased Ferumoxytol Use In An Infusion Clinic." Blood 116, no. 21 (November 19, 2010): 5151. http://dx.doi.org/10.1182/blood.v116.21.5151.5151.
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Abstract Abstract 5151 Patients with iron deficiency anemia (IDA) may require intravenous (IV) iron supplementation in an outpatient hematology setting. Such infusions require multiple visits and several hours of patient time. Ferumoxytol (Feraheme®) Injection is a novel IV iron approved for IDA in patients with reduced kidney function (CKD stages 1–5). Ferumoxytol requires fewer visits and fewer hours per treatment than other IV iron treatments. For instance, iron sucrose is generally given to nondialysis CKD patients in 200 mg doses given in five separate 1 hour infusions while ferumoxytol may be given in 510 mg doses given as a rapid injection in 2 visits. The objective of this analysis was to understand the impact of increased ferumoxytol utilization on patient, staff and financial efficiency metrics for an outpatient infusion clinic. Data on IV iron and other procedure mix, payer mix, length of clinic visit, medication and administration costs, and treatment revenue were collected from hospital financial data, staff interviews and pharmacy records for the 10-chair outpatient infusion clinic of a 325-bed academically-affiliated, non-profit hospital from January 1, 2008 through June 30, 2010. Cost of medication and administration used in each procedure came from the hospital's cost accounting system, revenue was captured as the amounts reimbursed by payers and margin was calculated as the difference between costs and revenue. Cost, revenue, margin and chair time required per IV iron treatment were analyzed for each year and estimated for 2011 utilization. Per hour efficiency metrics were calculated as the total revenue divided by total hours for each procedure. Revenue and margin per hour for the clinic's other administered therapies were also analyzed and modeled to quantify the projected financial impact of allocating freed IV iron chair time to these therapies. The clinic estimates that 80% of patients receiving IV iron treatment have reduced kidney function. Ferumoxytol treatment became available in 2009 and its share of the clinic's administered IV iron increased from 0% in 2008, to 25% in 2009, and to 42% in 2010. From 2008 to 2010, the clinic's use of iron sucrose dropped from 12% to 4%, sodium ferric gluconate decreased from 65% to 5% and iron dextran increased from 23% to 49%. The clinic forecasts that ferumoxytol will represent 60% (in 75% of ferumoxytol-eligible patients) of all IV iron administered in 2011. Because ferumoxytol requires 30 minutes per visit vs. 1.5 to 4.5 hours for other IV iron treatments, the average number of patient hours required to infuse a gram of IV iron in the clinic dropped 80% from 9.6 hours in 2008 to 1.9 hours in 2010. Furthermore, our study estimates that the clinic saved 282 hours of chair time in 2009 and the first half of 2010, and will save an additional 23 hours in 2011 by further increasing ferumoxytol utilization. Staff interviews suggested that ferumoxytol IV iron procedures were associated with improved clinic efficiencies such as reduced pharmacy preparation time (10-15 minutes less time) and improved availability of high demand equipment such as IV smart pumps. While total IV iron medication cost increased from 2008 to 2010, decreased chair time resulted in increased revenue per hour for IV iron medication (542%) and IV iron administration (153%). IV iron medication and administration margins per hour also increased (370% and 571%, respectively), moving the clinic's overall IV iron treatment margin per hour in line with their higher margin therapeutics, such as chemotherapy agents, erythropoietin, and monoclonal antibodies. By 2011, the clinic will have increased IV iron medication and administration revenue per hour by 858% and 195%, respectively over 2008 figures, and margins per hour by 588% and 753%, respectively, over 2008 figures. Given the clinic's average revenue and margin per hour for the current mix of other (non-IV iron) infusion therapies, reallocation of freed chair hours to other infusion therapies represents an additional clinic revenue and margin opportunity of $191,669 and $18,670, respectively. In conclusion, increasing use of ferumoxytol in an outpatient infusion clinic was associated with patient, staff and clinic efficiencies including fewer IV iron patient visits, decreased IV iron procedure time, the opportunity for increased clinic throughput and a substantial increase in overall IV iron revenue and margin per hour. Disclosures: Meyers: AMAG Pharmaceuticals, Inc.: Honoraria. Erdal:Boston Strategic Partners: Consultancy. Khan:Boston Strategic Partners: Consultancy. McKee:AMAG Pharmaceuticals, Inc.: Consultancy. Lahue:AMAG Pharmaceuticals, Inc.: Employment.
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Brodie, Christopher, Oliver Kracht, and Andreas Hilkert. "Tracing the Geographical Origin of Roasted and Green Coffee Using Isotope Fingerprints." Journal of AOAC INTERNATIONAL 102, no. 2 (March 1, 2019): 653–54. http://dx.doi.org/10.5740/jaoacint.18-0314.
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Abstract Background: Coffee is one of the most popular beverages worldwide, sourced from different geographical regions. To ensure that coffeebeans come from labelled locations, laboratories need an analytical solution that can discriminate geographical origin. Coffee beans have a fingerprint, a unique chemical signature that allows them to be identified: Isotope fingerprints of carbon, nitrogen, sulfur, hydrogen, and oxygen have been reliably used for origin claim verification. Objective: Show that hydrogen and oxygen isotope fingerprints from green and roasted coffee beans can determine the origin of coffee beans. Methods: The coffee beans were initially ground to as fine as possible a powder using a cryo-mill. Following, samples were weighed into tin capsules and introduced to the Thermo Scientific EA IsoLink™ IRMS System via the Thermo Scientific MAS Plus autosampler, where they were pyrolyzed at 1450°C, and converted to H2 and CO for analysis. Results: The hydrogen and oxygen isotope fingerprints of the coffee beans show that they can be clearly differentiated at the continent scale. Conclusions: It is evident that measuring the isotope fingerprint of coffee beans helps support legislation on food integrity and labelling (EC Reg. No. 1169/2011) and product geographical indication/origin (EC Reg. No. 510/2006), therefore protecting consumers and brands. The origin of a coffee bean can be determined using their hydrogen and oxygen isotope fingerprints. Highlights: Hydrogenand oxygen isotope fingerprints can help determine the origin of coffee beans, allowing the label claim to be verified.
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Chávez, Roberto O., Duncan A. Christie, Matías Olea, and Talia G. Anderson. "A Multiscale Productivity Assessment of High Andean Peatlands across the Chilean Altiplano Using 31 Years of Landsat Imagery." Remote Sensing 11, no. 24 (December 10, 2019): 2955. http://dx.doi.org/10.3390/rs11242955.
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The high Andean peatlands, locally known as “bofedales”, are a unique type of wetland distributed across the high-elevation South American Altiplano plateau. This extensive peatland network stores significant amounts of carbon, regulates local and regional hydrological cycles, supports habitats for a variety of plant and animal species, and has provided critical water and forage resources for the livestock of the indigenous Aymara communities for thousands of years. Nevertheless, little is known about the productivity dynamics of the high Andean peatlands, particularly in the drier western Altiplano region bordering the Atacama desert. Here, we provide the first digital peatland inventory and multiscale productivity assessment for the entire western Altiplano (63,705 km2) using 31 years of Landsat data (about 9000 scenes) and a non-parametric approach for estimating phenological metrics. We identified 5665 peatland units, covering an area of 510 km2, and evaluated the spatiotemporal productivity patterns at the regional, peatland polygon, and individual pixel scales. The regional assessment shows that the peatland areas and peatlands with higher productivity are concentrated towards the northern part of our study region, which is consistent with the Altiplano north–south aridity gradient. Regional patterns further reveal that the last seven years (2011–2017) have been the most productive period over the past three decades. While individual pixels show contrasting patterns of reductions and gains in local productivity during the most recent time period, most of the study area has experienced increases in annual productivity, supporting the regional results. Our novel database can be used not only to explore future research questions related to the social, biological, and hydrological influences on peatland productivity patterns, but also to provide technical support for the sustainable development of livestock practices and conservation and water management policy in the Altiplano region.
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Kleiv, Ø., A. Folkestad, J. Høkedal, K. Sørensen, and E. Aas. "Estimation of upward radiances and reflectances at the surface of the sea from above-surface measurements." Ocean Science 11, no. 5 (October 2, 2015): 779–88. http://dx.doi.org/10.5194/os-11-779-2015.
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Abstract. During 4 field days in the years 2009–2011, 22 data sets of measurements were collected in the inner Oslofjord, Norway. The data consist of recordings of spectral nadir radiances in air and water as well as spectral downward irradiance in air. The studied wavelengths are 351, 400, 413, 443, 490, 510, 560, 620, 665, 681, 709 and 754 nm. The water-leaving radiance and the reflected radiance at the sea surface have been obtained from the measured nadir radiances in air and water, where the latter radiance has been extrapolated upwards to the surface. For comparison we present a simpler and much faster method that determines the water-leaving and reflected radiances solely from above-surface measurements of upward nadir radiance and downward irradiance. This new method is based on an assumption about similarity in spectral shape of the radiance reflected at the surface, and it makes use of the small ratio between water-leaving and reflected radiances at 351 and 754 nm in the Oslofjord. A comparison between the quantities determined by the two mentioned methods shows that the average relative deviations between their results are less than or equal to 15 % for the reflected radiance, at the studied wavelengths. The average relative deviation of the water-leaving radiance at 560 nm is 24 %. These results are obtained for a cloudiness range of 1–8 oktas (12.5–100 %) and solar zenith angles between 37 and 51°. We consider these to be acceptable uncertainties for a first check of satellite products in the inner Oslofjord.
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Tang Girdwood, Sonya, Matthew Hall, James W. Antoon, Kathryn E. Kyler, Derek J. Williams, Samir S. Shah, Lucas E. Orth, Jennifer Goldman, James A. Feinstein, and Laura B. Ramsey. "Opportunities for Pharmacogenetic Testing to Guide Dosing of Medications in Youths With Medicaid." JAMA Network Open 7, no. 2 (February 13, 2024): e2355707. http://dx.doi.org/10.1001/jamanetworkopen.2023.55707.
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ImportanceThere are an increasing number of medications with a high level of evidence for pharmacogenetic-guided dosing (PGx drugs). Knowledge of the prevalence of dispensings of PGx drugs and their associated genes may allow hospitals and clinical laboratories to determine which pharmacogenetic tests to implement.ObjectivesTo investigate the prevalence of outpatient dispensings of PGx drugs among Medicaid-insured youths, determine genes most frequently associated with PGx drug dispenses, and describe characteristics of youths who were dispensed at least 1 PGx drug.Design, Setting, and ParticipantsThis serial cross-sectional study includes data from 2011 to 2019 among youths aged 0 to 17 years in the Marketscan Medicaid database. Data were analyzed from August to December 2022.Main Outcomes and MeasuresPGx drugs were defined as any medication with level A evidence as determined by the Clinical Pharmacogenetics Implementation Consortium (CPIC). The number of unique youths dispensed each PGx drug in each year was determined. PGx drugs were grouped by their associated genes for which there was CPIC level A evidence to guide dosing, and a dispensing rate (No. of PGx drugs/100 000 youths) was determined for each group for the year 2019. Demographics were compared between youths dispensed at least 1 PGx drug and those not dispensed any PGx drugs.ResultsThe number of Medicaid-insured youths queried ranged by year from 2 078 683 youths in 2011 to 4 641 494 youths in 2017, including 4 126 349 youths (median [IQR] age, 9 [5-13] years; 2 129 926 males [51.6%]) in 2019. The proportion of Medicaid-insured youths dispensed PGx drugs increased from 289 709 youths (13.9%; 95% CI, 13.8%-14.0%) in 2011 to 740 072 youths (17.9%; 95% CI, 17.9%-18.0%) in 2019. Genes associated with the most frequently dispensed medications were CYP2C9, CYP2D6, and CYP2C19 (9197.0 drugs [95% CI, 9167.7-9226.3 drugs], 8731.5 drugs [95% CI, 8702.5-8759.5 drugs], and 3426.8 drugs [95% CI, 3408.1-3443.9 drugs] per 100 000 youths, respectively). There was a higher percentage of youths with at least 1 chronic medical condition among youths dispensed at least 1 PGx drug (510 445 youths [69.0%; 95% CI, 68.8%-69.1%]) than among 3 386 277 youths dispensed no PGx drug (1 381 544 youths [40.8%; 95% CI, 40.7%-40.9%) (P &lt; .001) in 2019.Conclusions and RelevanceIn this study, there was an increasing prevalence of dispensings for PGx drugs. This finding suggests that pharmacogenetic testing of specific drug-gene pairs should be considered for frequently prescribed PGx drugs and their implicated genes.
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Yeh, Wei Ming. "New Trend of Wi-Fi DSC." Advanced Materials Research 716 (July 2013): 516–20. http://dx.doi.org/10.4028/www.scientific.net/amr.716.516.
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Since 2011, many Japanese DSC manufactures were anxious to explore some new possible solutions, in order to fill up the niche of technical advanced models or nostalgia models for special users, such as: Canon PowerShot SX50 (50x optical zoom), Panasonic LX7 (F1.4 Aperture), Fujifilm Xpro-1(nostalgia),and Canon IXUS 510 HS(Wi-Fi), NikonD3200(Wi-Fi),SamsungNX1000(Wi-Fi), Nikon S800C(Android). In fact, in 3C market, both hot-selling Smartphone (Multi-function Cell Phone) industries and DSC manufactures may have mutual interested which can work together to produce better and suitable photo components ever before. It is a new trend for Smartphones have better photo quality, and DSCs have Wireless Sharing Technique (Sharing Photos by Internet). Basically, this Wireless Sharing Technique for DSCs, only existing on relatively inexpensive, non-professional, DSLR-like, and EVIL cameras before late 2012, but are highly adapted since early 2013.This is the main target we are looking for, and we check every possible point what could be the real advantages and disadvantages for those bright new DSCs with Wi-Fi system. In our experiment, we collect more than 300 cases from the telephone survey during September 2012 to January 2013. Total of 210 cases fulfilled with the conditions. To probe mainly into the relationship between Wi-Fi DSC confidence level and 3 potential groups of people: IT administrators (IT), Multimedia Specialist (MS) , and college student (CS). We are probe into this highly competitively market with brilliant creative design, and hope to offer an objective suggestion for both industry and education administers. .
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Flatman, L. K., S. Bernatsky, I. Malhamé, Y. St-Pierre, O. Basso, A. Berard, and E. Vinet. "POS0936 TUMOUR NECROSIS FACTOR INHIBITORS USE AND DISCONTINUATION AMONG PREGNANT WOMEN WITH CHRONIC INFLAMMATORY DISEASES." Annals of the Rheumatic Diseases 82, Suppl 1 (May 30, 2023): 780.1–780. http://dx.doi.org/10.1136/annrheumdis-2023-eular.527.
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BackgroundPrevious guidelines (2006) recommended that tumour necrosis factor inhibitors (TNFi) be discontinued during pregnancy. Despite new guidelines (2016 & 2020) now recommending against this, the choice to stop TNFi pre-conception is patient- and provider-dependent. Observational studies have evaluated use of disease-modifying anti-rheumatic drugs (DMARDs) during pregnancy, but few have specifically assessed TNFi discontinuation pre-conception. Understanding trends and predictors of TNFi discontinuation pre-conception may help inform initiatives to improve care and optimize maternal and fetal outcomes.ObjectivesWe examined trends in TNFi discontinuation pre-conception over time, and evaluated the characteristics of pregnant women with chronic inflammatory diseases who stopped using TNFi pre-conception (without resuming in pregnancy) compared with those who used TNFi at any time during pregnancy.MethodsWe created a cohort of pregnant women with rheumatoid arthritis (RA), ankylosing spondylitis, psoriatic arthritis (PsA), psoriasis (PsO), and/or inflammatory bowel diseases (IBD) who delivered between 2011 and 2019, using the MarketScan commercial database. TNFi use was defined as at least 1 filled prescription or infusion procedure claim, categorized according to the timing of the filled prescription or infusion procedure date in relation to the gestational period: 1) TNFi pre-conception only (i.e. at least 1 prescription filled or infusion procedure claim in the 12 weeks preceding the gestational period but none within the gestational period) or 2) TNFi use at any time during pregnancy (i.e. any prescription filled or infusion procedure claim during the gestational period, including restarts, new starts, and those continuing from pre-conception).ResultsWe identified 3,372 pregnancies; 13% discontinued TNFi in the 12 weeks before conception and did not restart, and 86% were exposed to TNFi during pregnancy. Pregnancies in IBD patients accounted for 47% of all pregnancies. Nearly all pregnancies with IBD were exposed to TNFi during pregnancy (95%). Compared to those with IBD, more patients with RA (difference of 18%, 95% CI 15-21%) and PsA/PsO (20%, 95% CI 16-24%) discontinued their TNFi. Corticosteroid use was similar in both TNFi exposure groups, while patients who took TNFi during pregnancy were more likely to use non-biologic DMARDs concomitantly. Over time, a lower proportion of patients stopped TNFi pre-conception (2011-2013 19% vs 2014-2016 13% vs 2017-2019 10%; p-value for trend <0.0001).ConclusionIn our sample, 13% discontinued TNFi in the 12 weeks before conception and did not restart. The proportion of patients stopping TNFi pre-conception between 2017-2019 decreased compared to earlier years, possibly reflecting updated guidelines. Further research on TNFi discontinuation in the years after the 2020 ACR guidelines is warranted.Table 1.Characteristics of pregnant women with chronic inflammatory diseases who stopped TNFi pre-conception and those who took TNFi at any time during gestation (n=3,372).Total (n=3372)TNFi pre-conception only (n=470)TNFi any time during pregnancy (n=2902)Maternal Diagnosis, n (%)470/3372 (14)2902/3372 (86)All1588 (47)82/1588 (5)1506/1588 (95)IBD only807 (24)187/807 (23)620/807 (77)RA only530 (16)132/530 (25)398/530 (75)PsA/PsO onlyCorticosteroids, n (%)1085 (32)149/470 (32)936/2902 (32)Non-biologic DMARDs, n (%)713 (21)66/470 (14)647/2902 (22)Delivery Year, n (%)2011-2013All1202 (36)224/1202 (19)978/1202 (81)IBD only510 (15)36/510 (7)474/510 (93)RA only345 (29)96/345 (29)249/345 (72)PsA/PsO only200 (6)61/200 (30)139/200 (70)2014-2016All1138 (34)148/1138 (13)990/1138 (34)IBD only549 (16)20/549 (4)529/549 (96)RA only266 (8)60/266 (23)206/266 (8)PsA/PsO only157 (5)41/157 (26)116/157 (74)2017-2019All1032 (31)98/1032 (9)934/1032 (91)IBD only529 (16)26/529 (5)503/529 (95)RA only196 (6)31/196 (16)165/196 (84)PsA/PsO only173 (5)30/173 (17)143/173 (83)AcknowledgementsThis research was funded by the Canadian Institutes of Health Research (CIHR) project grant awarded to EV. LKF is supported by a CIHR Canada Graduate Scholarships Doctoral Award. EV is supported by a salary support award from the Arthritis Society.Disclosure of InterestsNone Declared.
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Baugh, Christine M., Gil S. Weintraub, Andrew J. Gregory, Aristarque Djoko, Thomas P. Dompier, and Zachary Y. Kerr. "Descriptive Epidemiology of Injuries Sustained in National Collegiate Athletic Association Men’s and Women’s Volleyball, 2013-2014 to 2014-2015." Sports Health: A Multidisciplinary Approach 10, no. 1 (October 6, 2017): 60–69. http://dx.doi.org/10.1177/1941738117733685.
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Background: There were 18,844 volleyball players in the National Collegiate Athletic Association (NCAA) in the 2014-2015 academic year. Little research has examined sex-based differences among these athletes. Purpose: To examine injury epidemiology in NCAA men’s and women’s volleyball athletes. Study Design: Descriptive epidemiology study. Level of Evidence: Level 3. Methods: Injury surveillance data from the 2013-2014 through 2014-2015 academic years were obtained from the NCAA Injury Surveillance Program for 6 men’s and 33 women’s collegiate volleyball teams. Injury rates per 1000 athlete-exposures (AEs) and injury rate ratios (IRRs) with 95% CIs were calculated. Time-loss (TL) injuries resulted in participation restriction for at least 24 hours, and non-time-loss (NTL) injuries resulted in participation restriction of less than 24 hours. Results: Overall, 83 and 510 injuries were reported in men and women, respectively, leading to injury rates of 4.69 and 7.07 per 1000 AEs. The injury rate was greater in women than men (IRR, 1.51; 95% CI, 1.19-1.90). TL injury rates were 1.75 and 2.62 per 1000 AEs for men and women, respectively. The ankle was the most commonly injured body part among TL injuries (men, 25.8%; women, 24.3%); the knee was the most commonly injured body part among NTL injuries (men, 25.5%; women, 16.3%). Among TL injuries, common diagnoses included sprains (men, 25.8%; women, 31.2%) and concussions (men, 19.4%; women, 14.8%). Most TL concussions were due to ball contact (men, 83.3%; women, 53.6%). Compared with men, women had a greater NTL overuse injury rate (IRR, 3.47; 95% CI, 1.61-7.46). Compared with women, men had a greater TL injury rate associated with ball contact (IRR, 2.24; 95% CI, 1.07-4.68). Conclusion: There are differences in injury patterns and rates between male and female intercollegiate volleyball players. Although a limited-contact sport, a notable number of concussions were sustained, mostly from ball contact. Clinical Relevance: Understanding injury patterns may aid clinicians in injury diagnosis, management, and prevention.
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Mehring, Michael, Ewan Donnachie, Antonius Schneider, Martin Tauscher, Roman Gerlach, Constanze Storr, Klaus Linde, Andreas Mielck, and Werner Maier. "Impact of regional socioeconomic variation on coordination and cost of ambulatory care: investigation of claims data from Bavaria, Germany." BMJ Open 7, no. 10 (October 2017): e016218. http://dx.doi.org/10.1136/bmjopen-2017-016218.
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ObjectivesA considerable proportion of regional variation in healthcare use and health expenditures is to date still unexplained. The aim was to investigate regional differences in the gatekeeping role of general practitioners and to identify relevant explanatory variables at patient and district level in Bavaria, Germany.DesignRetrospective routine data analysis using claims data held by the Bavarian Association of Statutory Health Insurance Physicians.ParticipantsAll patients who consulted a specialist in ambulatory practice within the first quarter of 2011 (n=3 616 510).Outcomes measuresOf primary interest is the effect of district-level measures of rurality, physician density and multiple deprivation on (1) the proportion of patients with general practitioner (GP) coordination of specialist care and (2) the mean amount in Euros claimed by specialist physicians.ResultsThe proportion of patients whose use of specialist services was coordinated by a GP was significantly higher in rural areas and in highly deprived regions, as compared with urban and less deprived regions. The hierarchical models revealed that increasing age and the presence of chronic diseases are the strongest predictive factors for coordination by a GP. In contrast, the presence of mental illness, an increasing number of medical condition categories and living in a city are predictors for specialist use without GP coordination. The amount claimed per patient was €10 to €20 higher in urban districts and in regions with lower deprivation. Hierarchical models indicate that this amount is on average higher for patients living in towns and lower for patients in regions with high deprivation.ConclusionThe present study shows that regional deprivation is closely associated with the way in which patients access primary and specialist care. This has clear consequences, both with respect to the role of the general practitioner and the financial costs of care.
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Hiramoto, Shuji, Ayako Kikuchi, Hori Tetsuo, Akira Yoshioka, and Tomoko Tamaki. "A picture of early death after admission in patients with advanced cancer at the end-of-life." Journal of Clinical Oncology 35, no. 31_suppl (November 1, 2017): 80. http://dx.doi.org/10.1200/jco.2017.35.31_suppl.80.
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80 Background: Little is unknown about a picture of early death after admission in terminal phase of advanced cancer patients. Previous studies have reported that approximately 14.3% of patients with cancer enroll in hospice in the last 3days of life. Methods: We retrospectively analyzed data for 510 advanced cancer patients at the end of life between August 2011 and August 2016, and contained deceased 83 (16.3%) patients within 3days after admission in our institute. We divided into deceased patients within 3days and more than 4days after admission. Primary endpoints are to compare each symptom (delirium, cancer pain, dyspnea, nausea and vomiting, fatigue) and intervention (hydration, continuous sedation, opioid) at the end of life. Secondary endpoints are association between prognostic factor and early death (within 3days) after admission. Results: Symptoms about delirium, cancer pain, dyspnea, nausea and vomiting were no significant difference between deceased patients within 3days and more than 4days after admission. Mean hydration at the end of life was more significantly volume of infusion for patients in within 3days (0.34 Litters/day) than in over 4 days (0.20 Litters/day). Continuous sedation was significantly less for patients within 3days (4.82%) than in over 4 days (28.64%). Mean of opioid use was significantly less for patients within 3days (Oral morphine dose 23.54mg/day) than in over 4 days (41.11mg/day). In univariate analysis primary site of cancer was tend to (p = 0.086), and number of metastatic site (p = 0.018) and consciousness level ( < 0.0001) and performance status ( < 0.0001) were significantly associated with early death. In multivariate analysis number of metastatic site (p = 0.057) and consciousness level ( < 0.0001) and performance status (p = 0.0004) were significantly associated with early death. Conclusions: We reports a picture of early death after admission in advanced cancer patients at the end-of-life, and number of metastatic site and consciousness level and performance status might be predictors for short-term prediction model.
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Behnle, Stefan, and Reinhold F. Fink. "UREMP, RO-REMP, and OO-REMP: Hybrid perturbation theories for open-shell electronic structure calculations." Journal of Chemical Physics 156, no. 12 (March 28, 2022): 124103. http://dx.doi.org/10.1063/5.0081285.
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An accurate description of the electron correlation energy in closed- and open-shell molecules is shown to be obtained by a second-order perturbation theory (PT) termed REMP. REMP is a hybrid of the Retaining the Excitation degree (RE) and the Møller–Plesset (MP) PTs. It performs particularly encouragingly in an orbital-optimized variant (OO-REMP) where the reference wavefunction is given by an unrestricted Slater determinant whose spin orbitals are varied such that the total energy becomes a minimum. While the approach generally behaves less satisfactorily with unrestricted Hartree–Fock references, reasonable performance is observed for restricted Hartree–Fock and restricted open-shell Hartree–Fock references. Inclusion of single excitations to OO-REMP is investigated and found—as in similar investigations—to be dissatisfying as it deteriorates performance. For the non-multireference subset of the accurate W4-11 benchmark set of Karton et al. [Chem. Phys. Lett. 510, 165–178 (2011)], OO-REMP predicts most atomization and reaction energies with chemical accuracy (1 kcal mol−1) if complete-basis-set extrapolation with augmented and core-polarized basis sets is used. For the W4-11 related test-sets, the error estimates obtained with the OO-REMP method approach those of coupled-cluster with singles, doubles and perturbative triples [CCSD(T)] within 20%–35%. The best performance of OO-REMP is found for a mixing ratio of 20%:80% MP:RE, which is essentially independent of whether radical stabilization energies, barrier heights, or reaction energies are investigated. Orbital optimization is shown to improve the REMP approach for both closed and open shell cases and outperforms coupled-cluster theory with singles and doubles (CCSD), spin-component scaled Møller-Plesset theory at second order (SCS-MP2), and density functionals, including double hybrids in all the cases considered.
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Briko, Nikolay I., Platon D. Lopukhov, Andrei D. Kaprin, Elena G. Novikova, Olga I. Trushina, Aleksey A. Khaldin, Dinara R. Isaeva, and Anna I. Skvortsova. "HPV-associated lesions in the Russian Federation: assessment of the problem." Journal of Modern Oncology 21, no. 1 (March 15, 2019): 45–50. http://dx.doi.org/10.26442/18151434.2019.190199.
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Aim. To estimate the prevalence and trends of the long-term dynamics of morbidity and mortality associated with various manifestations of HPV infection in Russia in recent years. Materials and methods. We analyzed retrospective data with diagnostic codes related to cervical cancer, penile cancer, anal canal cancer, head and neck cancer (including the oral cavity, oropharynx, larynx and larynx), anogenital (venereal) warts from the official statistic of cancer register and STIs using incidence and mortality rates in Russia between January 2007 and December 2016 and retrospective data with diagnostic codes related to cancer of the vulva and cancer of the vagina between January 2011 and December 2016. Based on the available data on the involvement of HPV in the occurrence of pathological changes, the annual generalized indices for HPV-associated neoplasms were calculated. Results. The estimated number of HPV-associated lesions in the Russian Federation for 2007-2016 amounted to 5 761 170 cases, of which 224 630 - among men and 5 536 540 - among women. The estimated number of deaths from HPV-associated cancers was 109 510 cases, of which 32 080 - among men and 77 430 - among women. The estimated incidence of HPV-associated cancers neoplasms during this period increased by 10% among the male population and by 22% among the female population, reaching 8.0 cases per 100 000 male population in 2016 and 25.2 cases per 100 thousand female population. The death rate from HPV-associated cancers did not change significantly, and in 2016 it was 4.9 cases per 100 thousand male population and 10.2 cases per 100 thousand female population. Conclusion. There is an increase in morbidity and stabilization of mortality rates from HPV-associated cancers for both female and male populations, and a decrease in the incidence of anogenital (venereal) warts.
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Xu, Huiwen, Supriya Gupta Mohile, Eva Culakova, John R. Bowblis, Orna Intrator, Marielle Jensen-Battaglia, Po-Ju Lin, et al. "Patterns and predictors of rehabilitation therapy among older patients with advanced cancer admitted to nursing homes: A SEER-Medicare analysis." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): 6585. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.6585.
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6585 Background: Functional impairments affect > 40% of hospitalized patients (pts) with advanced cancer. After hospital discharge, about 20% of pts received rehabilitation (rehab) in nursing homes (NHs) to maintain functional independence. There is evidence from broad pt cohorts that Medicare Prospective Payment (PP) financially incentivizes NHs to provide extra rehab. This study examines rehab utilization among pts with advanced cancer admitted to NHs. Methods: The 2011-2016 SEER-Medicare data were linked with NH Minimum Data Set 3.0 data, which includes sociodemographic and clinical characteristics at admission. Study cohort included traditional Medicare pts with stage IV breast, lung, and colorectal cancer who were admitted to NHs after hospital discharge. Outcomes: total weekly rehab minutes of physical therapy, occupational therapy, and speech-language pathology; ultra-high rehab (≥720 min/wk); and rehab within 10 minutes of threshold (720-730 min/wk). Function and cognition were assessed by Activities of Daily Living (ADL) [7 domains; total score ranges 0 to 28 (higher = dependent)] and Cognitive Function Scale (intact, mild, moderate, severe impairment). Charlson Comorbidity Index (CCI) and survival from NH admission were computed. Generalized linear mixed models examined predictors of rehab outcomes adjusting for NH random effects. Results: A total of 7,453 pts were included (mean age 78.0, 85.8% White, 74.1% lung/ 16.1% colorectal/ 9.7% breast cancer; 76.1% had surgery, 8.9% had chemotherapy; mean CCI 1.9). The mean ADL score was 18.0, with on average 4.7 impairments; 40.2% reported ≥ mild cognitive impairment. Pts received on average 498 (SD = 245) min/wk rehab, but the distribution was trimodal. The number of pts who received 720-730 min/wk rehab was 2.7 times of the secondary peak at 500-510. From 2011-2016, the proportion of pts receiving ultra-high therapy (19.5%-48.4%) and within-threshold rehab (11.0%-32.0%) more than doubled. Only 5.9% of pts were documented on admission as having a life expectancy < 6 months, yet 32.1% and 74.3% died in 30 days and 6 months, respectively. Multivariable regressions indicate that compared to pts with ≥6 months’ expectancy, those with < 6 months’ expectancy received less rehab (β = -117.6), especially ultra-high rehab (odds ratio = 0.31). Pts with cognitive impairments received less rehab. Conclusions: Rehab utilization in older NH pts with advanced cancer mirrors patterns found in broader cohorts. Under PP, rehab minutes provided strongly followed payment thresholds. Over 5 years, more pts were provided 720-730 min/wk rehab, and 1/3 of these pts were at the end of life. Poor prognostication might contribute to the use of ultra-high rehab. Future work should evaluate whether the new Patient Driven Payment Model avoids excessive rehab use in patients with limited life expectancies.
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Mohos, Elemér, Attila Nagy, György Szabados, Lóránt Szabó, László Szabó, Béla Gál, Miklós Kiss, et al. "Metabolikus sebészeti tevékenységünk, 2010–2016." Magyar Sebészet (Hungarian Journal of Surgery) 69, no. 4 (December 2016): 171–77. http://dx.doi.org/10.1556/1046.69.2016.4.5.
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Absztrakt Bevezetés: A kóros elhízás és az okozott társbetegségek, elsősorban a 2-es típusú diabetes prevalenciája az elmúlt évtizedekben rohamos növekedésnek indult. Miután a konzervatív kezelési módszerek (diéta, tréning) legtöbbször nem hoznak megoldást, egyre nagyobb az igény a metabolikus sebészeti beavatkozásokra. Módszer: Osztályunkon az elmúlt hat és fél évben 514 laparoszkópos Roux Y gyomorbypassműtétet (LRYGB) és 54 laparoszkópos gyomorsleeve-reszekciót (LGSR) végeztünk. Random kiválasztott 40, gyomorbypassműtéten és 15 sleeve-reszekción átesett beteg adatait dolgoztuk fel. Ismertetésre kerülnek az alkalmazott indikációs kritériumok, a pre- és posztoperatív rutineljárások, az elért eredmények, illetve a komplikációk típusa és aránya. Eredmények: Tapasztalataink alapján mindkét műtéti beavatkozás relatív alacsony szövődményráta mellett végezhető és hosszú távon is hatékony mind a testsúlycsökkenés, mind a társbetegségek javulásának vonatkozásában. Gyomorbypass után nagyobb mértékű fogyást (testsúlyfelesleg-csökkenés 88% vs. 68%) és a 2-es típusú diabetes, a hypertonia és a gastrooesophagealis reflux magasabb arányú javulását tapasztaltuk a sleeve-reszekcióhoz viszonyítva. Konklúzió: Eredményeink alapján az LRYGB-t részesítjük előnyben, sleeve-reszekciót akkor indikálunk, amikor bypass végzésére nincs, illetve csak magas rizikó mellett volna lehetőség, természetesen figyelembe véve a beteg ez irányú, egyénre szabott igényeit is.
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Gil, Mariana, Renata D'Alpino Peixoto, Thais Passarini, Maria Cecilia Mathias, Eduardo Dias de Moraes, Jorge Alexandre Canedo, Sabrina Pereira, et al. "Triplets versus doublets in the treatment of right-sided metastatic colorectal cancer in real-world setting: A propensity-score weighting analysis." Journal of Clinical Oncology 41, no. 4_suppl (February 1, 2023): 55. http://dx.doi.org/10.1200/jco.2023.41.4_suppl.55.
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55 Background: Right-sided metastatic colorectal cancer (mCRC) has a worse prognosis and the best first-line treatment is still uncertain. The aim of this study was to analyze progression-free survival (PFS) and overall survival (OS) comparing triplet versus doublet backbone chemotherapy in first-line setting for right-sided mCRC. Methods: Retrospective study evaluating 510 patients with mCRC who were treated in a private institution in Brazil from January 2011 to December 2019. Information of 118 patients with right-sided primary tumor was analyzed in this study. Demographic and clinical data were retrieved from electronic medical records. PFS and OS were calculated in months (m) using propensity-score weighting analysis (PSWA) due to expected disparity between the number of patients treated with triplet and doublet regimens. Variables used to balance patient groups were age; metastasectomy; primary tumor resection; bevacizumab use; BRAF and RAS mutation status. Results: The median follow-up was 31 months. Our population was mostly composed of elderly (64%) and female (52%) patients. First-line treatment with triplet backbone chemotherapy was done in 16 patients (14%). Primary tumor resection was done in 14% of the cases, 55% underwent metastasectomy, and 57% received anti-VEGF treatment. BRAF mutation was found in 9% of the patients and RAS mutation in 46%. After PSWA we found a significant better median PFS among patients treated with triplet regimen: 12.7m versus 8.9m compared to those receiving doublet backbone chemotherapy, with a hazard ratio of 0.64 (CI 95%: 0.42 – 0.97); p-value: 0.037. No significant difference was found in OS (29.8m versus 45.5m) between triplet and doublet therapy groups, respectively. Conclusions: In our study we found a significantly better PFS with triplet backbone chemotherapy in first-line setting for right-sided mCRC, encouraging the use of this regimen in treatment-naive selected patients. However, no difference in OS was found, probably due to subsequent treatments. PSWA is an acceptable and needed tool to enable retrospective real world studies involving treatments with expected uneven distribution. More studies are needed to answer the best strategy to target right-sided mCRC, which remains a challenge for oncologists, with unmet needs.
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Viguier, Jérôme, Yvan Coscas, Chantal Touboul, Jean F. Morere, Jean-Yves Blay, Xavier B. Pivot, Christine Lhomel, and François Eisinger. "Knowledge of the French population on colorectal cancer screening: Data from the EDIFICE 3 survey." Journal of Clinical Oncology 31, no. 4_suppl (February 1, 2013): 352. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.352.
Full textAbstract:
352 Background: In France, following a pilot population-based screening program in 2002-2003, a national organized program targeting 17 million people was progressively implemented from 2005 to 2009. EDIFICE surveys are iterative polls focusing on cancer screening behavior. The EDIFICE 3 survey was conducted in 2011 and partly dedicated to knowledge of the colorectal cancer screening process. Methods: This third nationwide observational study, EDIFICE 3, was conducted via phone interviews among a representative sample of 946 subjects aged between 50 and 74 years, who had never been treated for cancer. 59% of the population declared having undergone colorectal cancer screening (fecal test or colonoscopy). Results: Interviewed about the screening process, 510/946 (54%) of the French population were unaware of the procedure after a positive fecal test and 782/946 (83%) were unaware of how soon a new test should be performed after a negative result. Only 79/946 (8%) were aware of what to do after either a positive or a negative test and 47% in one out of the two cases. 84% of subjects over assessed (by a factor 2 to 10) the probability of having cancer after a positive test. In contrast, 65% were aware of the possibility of a false negative test. Only 3% of our sample know both the right screening agenda (every other year) and the need for a colonoscopy after a positive test. Neither gender, educational level and socio economic level significantly impacted the rate of right answers. Conclusions: This study demonstrates a lack of detailed knowledge on the colorectal cancer screening process in the French national program. This raises the issue of the fairness of the process (an ethical issue) and may be a reason for the current poor uptake (an effectiveness issue). This should be tackled by improving the transmission of information, preferentially via general practitioners, institutional letters sent directly to subjects (in our survey these two media were found to be readily accepted) and lay press.