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Al-Ani, Fatimah, Yo-Liang Teng, Alla Iansavichene, and Alejandro Lazo-Langner. "Evaluating the Effect of Ethnicity on the Risk of Venous Thromboembolism (VTE): A Systematic Review." Blood 126, no. 23 (December 3, 2015): 4714. http://dx.doi.org/10.1182/blood.v126.23.4714.4714.
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Abstract Background Studies of hospital discharge data and large observational cohorts show that the incidence of venous thromboembolism (VTE) varies by race. We sought to determine the incidence of VTE in each of the following ethnic groups Caucasians, Africans, Asians, and Hispanics. Methods A systematic literature search strategy was used to identify potential studies in MEDLINE, EMBASE, and CENTRAL using an OVID interface. The methodological quality of eligible studies was assessed according to Newcastle-Ottawa Quality Assessment Scale. The primary outcome measure was to identify the incidence/prevalence of VTE of each ethnic group available for the study in the context of a population based study. Results Out of 3418 potential studies, 19 met our inclusion criteria (Table). Of these, 9 studies were population based studies: 5 reported VTE incidence per 100,000 person-years (PY), 2 measured the standardized incidence ratio, and 2 European studies assessed VTE rate according to country of origin but not ethnicity (data not shown). In addition, 7 studies measured the hospital incidence rate of VTE, and 3 assessed VTE prevalence. Data could not be pooled due to marked heterogeneity including varied periods of study. VTE incidence per 100,000 PY was found to be between 162 and 439 in Caucasians, 143 and 746 in Africans, 3.2 and 16.6 in Asians. Hospital incidence of VTE per 100,000 PY was found to be between 21 and 131 in Caucasians, 22 and 155 in Africans, 2 and 26 in Asians, 33.1 and 71 in American Indians/Alaskan Indians, and 9 in Hispanics. Conclusions Our findings suggest a wide variation in reported incidence rates for VTE among different ethnic groups, even within the same group. In general, studies in Asian populations suggest a lower incidence of VTE. A marked heterogeneity of study designs, population settings prevent drawing firm conclusions. A significant risk of bias cannot be excluded for several studies. Further studies assessing concurrently the risk of VTE among different ethnicities in the same geographical area are needed. Table 1. Summary of the included studies. Study Country Time Period f/u duration Sample size VTE incidence /Prevalence (95% CI) Zakai, 2014 US 439,090 person year 51,149 Zakai: ARIC US 1987-1996 15,792 (I) Cauc.: 166 (1.48-1.86) Afr.: 259 (2.21-3.03) Zakai: CHS US 1989-1997 5,888 (I) Cauc.: 439 (3.13-6.16) Afr.: 746 (4.68-11.90) Zakai: REGARDS, Southeast area US 2003-2007 30,239 (I) Cauc.: 162 (1.26-2.07) Afr.: 224 (1.72-2.92) Zakai: REGARDS, Rest of US US 2003-2007 30,239 (I) Cauc.: 205 (1.58-2.66) Afr.: 143 (1.02-2.00) Deitelzweig, 2010 US 2002 46,652 (P) per 100,000 persons Cauc.: M 457, F NA Afr.: M 584, F NA Hisp.: M 94, F 93 Others: M 329, F 345 2005 46,652 (P) per 100,000 persons Cauc.: M 643, F 446 Afr.: M 784, F 444 Hisp.: M 149, F 154 Others: M 285, F 297 DeMonaco, 2008 US 1997 37,892 (HI) Cauc.: 44 Afr.: 53 2001 37,892 (HI) Cauc.: 56 Afr.: 60 Heit, 2010 US 2003-2009 2,397 (P) N(%) Cauc.: Total= 1381 (69) Afr.: Total=272 (69) N(%) Cauc.: VTE = 551 (27) Afr.: VTE = 75 (19) Hooper, 2003 US 1980-1996 (HI) American Indians/Alaskan Indians: 33.1 Jang, 2011 Korea 2004 (I) Asians: VTE: 8.83, DVT: 3.91, PE: 3.74 2008 (I) Asians: VTE: 13.8, DVT: 5.31 , PE: 7.01 Kitamukai, 2003 Japan 2000 (I) Asians: 3.2 (29.2-33.9) Klatsky, 2000 US 1978-1994 1,822,302 total person years 128,934 (HI) Cauc.: 21 Afr.: 22 Asians: 2 Hisp.: 9 Others (unspecified): 15 Lee, 2010 Taiwan 2001 & 2002 11,566 person year Crude Incidence per 100,000 person year: Asians: VTE=15.9 Liu, 2002 China 1997-2000 (I) Asians: 16.6 Sakuma, 2009 Japan 2006 (I) Asians: PE= 6.19 (51.7- 72.1) DVT= 11.5 (98.2-132.9) Schneider, 2006 US 1998-2000 (HI) Cauc.: M 36.47 ; F 37.96 Afr.: M 53.64 ; F 61.53 Stein, Am J Med. 2004 US 1990-1999 (HI) Cauc.: VTE= 122 Afr.: VTE= 134 Asians: VTE= 23 Stein, Arch Intern Med. 2004 US 1996-2001 (HI) Cauc.: 131 Afr.: 155 American Indians and Alaskan Indians: 71 Tan, 2007 Singa-pore 1998-2001 271 pairs of cases and controls (P) N(%) Asians: 32.1% (29.0-35.3) White, 2005 US 1996 21,002 (SIR): Cauc.: 103 (101-105) Afr.: 138 (132-145) Asians: 29 (27-32) Hisp.: 61 (59-64) Others: 72 (65-80) White, 1998 US 1991-1994 17991 (SIR): Cauc.: 23 Afr.: 29.3 Asians: 6 Hisp.: 13.9 Abbreviations. f/u: follow up; CI: confidence interval; (I): incidence per 100,000 PY; (P): prevalence; (HI): Hospital Incidence per 100,000 PY; (SIR): Standardized Incidence Rate; M:male; F: female; N: total number. Cauc. Caucasians, Afr. Africans, Hisp. hispanics Disclosures Lazo-Langner: Pfizer: Honoraria; Bayer: Honoraria.
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Wu, Hongsheng, Keqiang Ma, Biling Liao, Tengfei Ji, Shengmin Zhang, and Tiansheng Cao. "Comparative Analysis of Early Clinical Features and Complications of Different Types of Acute Pancreatitis." Oxidative Medicine and Cellular Longevity 2022 (June 25, 2022): 1–9. http://dx.doi.org/10.1155/2022/3771610.
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Background. Acute pancreatitis (AP) is a common surgical acute abdomen. Different kinds of pancreatitis may have different pathophysiological characteristics each other. The objective of this research was to investigate the early clinical features and complications of different types of acute pancreatitis. Methods. 787 AP patients admitted in the Huadu District People’s Hospital of Guangzhou during January 2009 and December 2019 were analyzed retrospectively. Among 787 AP patients, 520 (66.1%) were biliary AP (group I), 69 (8.7%) were alcoholic AP (group II), and 198 (25.2%) were hypertriglyceridemic AP (group III). According to the local and systemic complications and mortality in the early stage, we compared and analyzed the clinical characteristics and prognosis of different types of pancreatitis. Results. Mild acute pancreatitis accounted for the highest proportion (79.4%) in group I, while moderately severe acute pancreatitis in group II (36.2%) and severe acute pancreatitis in group III (62.6%). In terms of severity score of the pancreatitis, the average scores of BISAP, Ranson, APACHE-II, and MCTSI of the patients in group III were the highest ( p < 0.01 ). The incidence of acute peripancreatic fluid collection and infectious pancreatic necrosis was the highest in group III. The incidences of acute necrotic collection, pancreatic pseudocyst, and walled-off necrosis in group III were significantly higher than those in the other two groups ( p < 0.01 ). The incidences of systemic inflammatory response syndrome, sepsis, multiple organ failure, intra-abdominal hypertension, and mortality were highest in group III. Conclusions. There is an upward trend of the incidence rate of hypertriglyceridemic AP in recent years; it has been gradually developed into the second type of acute pancreatitis which is second only to the acute biliary pancreatitis. It is worthy to pay more and more attentions to it due to the feature of its younger onset, high incidence of complications, and high mortality.
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Delgado, Manuel, and Sarai Martín López. "La violencia contra lo sagrado. Profanación y sacrilegio: una tipología." Vínculos de Historia. Revista del Departamento de Historia de la Universidad de Castilla-La Mancha, no. 8 (June 20, 2019): 171. http://dx.doi.org/10.18239/vdh_2019.08.09.
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RESUMENDe entre todos los objetos, tiempos, espacios, palabras y seres que componen el mundo físico, algunos están investidos de un valor especial por cuanto se les atribuye la virtud de visibilizar las instancias invisibles de las que dependemos los mortales. Es lo sagrado. A lo sagrado se le depara un trato singular hecho de respeto, veneración o miedo, pero en ocasiones también de rencor y de odio por lo que encarna o representa. Es adorado, pero también, y acaso por las mismas razones, puede ser insultado, destruido, objeto de burla y, si tiene forma humana, martirizado o asesinado. La violencia contra lo sagrado puede caber en sistemas religiosos que le otorgan a la agresión un papel central en su universo mítico o ritual. También se ofende u agrede lo santo para grupos o pueblos a someter, puesto que en ello está resumido su orden del mundo. Desde esta perspectiva, el agravio, la irreverencia y el daño pasan a reclamar un lugar protagonista en los estudios sobre la institución religiosa de la cultura bajo las figuras del sacrilegio y la profanación.PALABRAS CLAVE: sagrado, profanación, sacrilegio, violencia religiosa, iconoclastia.ABSTRACTOf all the objects, times, spaces, words and beings that make up the physical world, some are invested with a special value because they are attributed the virtue of making visible the invisible instances on which we mortals depend. This is the sacred. The sacred is given a singular treatment combining respect, veneration or fear, but sometimes also resentment and hatred of what it embodies or represents. It is adored, but also, and perhaps for the same reasons, it can be insulted,destroyed, mocked and, if it has a human form, martyred or killed. Violence against the sacred can fit into religious systems that give aggression a central role in their mythical or ritual universe. Also offended or attacked is what is sacred for groups or peoples to be subdued, since in it an embodiment of their world order. From this perspective, aggravation, irreverence and damage occupy a central place in the studies on the religious institution of culture under the figures of sacrilege and profanation.KEY WORDS: sacred, profanation, sacrilege, religious violence, iconoclasm. BIBLIOGRAFÍAAgamben, G. (2005), Profanaciones, Barcelona, Anagrama.Arbeola, V. M. (1973), Socialismo y anticlericalismo, Madrid, Taurus.Arce Fustero, G. (2018), De espaldas a Cristo. Una historia del anticlericalisme en Colombia, 1849-1948, Medellín, Editorial Universidad de Medellín.Aston, M. (1988), England’s Iconoclasts, Oxford, Oxford University Press.Auzépy, M. F. (1987), “L’iconodulie: Défense de l’image ou de la devotion de l’image”, en Boesfplug, F. y Lossy, N. (comp.), Nicée II, 787-19 87. Douze siecles d’imagerie religieuse, París, Cerf, 157-164.Bataille, G. (2007 [1957]), El erotismo, Barcelona, Tusquets.Bateson, G. y Bateson, M. C. (1989), El temor de los ángeles. Epistemología de lo sagrado, Barcelona, Gedisa, 29-64.Bajtin, M. (1988 [1965]), La cultura popular en la Edad Media y el Renacimiento. El contexto de François Rabelais, Madrid, Alianza.Beçanson, A. (2003), La imagen prohibida: Una historia intelectual de la iconoclastia, Madrid, Siruela.Benjamin, W. (2014 [1921]), El capitalismo como religión, Madrid, La Llama.Benedict, R. (1938), “Religion”, en Boas, F. (ed.), General Anthropology, Nueva York, Columbia University Press, 627-655.Beránek, O. y Ťupek, P. (2018), The Temptation of Graves in Salafi Islam. Iconoclasm, Destruction and Idolatry, Edimburgo, Edinburgh University Press.Bernard, C. y Gruzinski, S. (1993), De la idolatría. Hacia una arqueología de las ciencias de la religión, México DF, FCE.Blom, P. (2007), Encyclopédie. El triunfo de la razón en tiempos irracionales, Barcelona, Anagrama.Caillois, R. (2014 [1939]), El hombre y lo sagrado, México DF, FCE.Crew, Ph. M. (1978), Calvinist Preaching and lconoclasm in the Neederlanden, 1544-1566, Cambridge, Cambridge University Press.Cottret, B. (1984), “Pour une sémiotique de la Réforme: Le Consensus Tigurinus (1549) et la Brève résolution... (1555) de Calvin”, Annales ESC, 40 (2), 265-285.Crouzet, D. (1990), Les Guerriers de Dieu. La violence au temps des troubles de religion, París, Champ Vallon, 2 vols.Cueva, J. de la, (1998): “El anticlericalismo en la Segunda República y la Guerra Civil”, en La Parra López, E. y Suárez Cortina, M. (eds.), El anticlericalismo español contemporáneo, Madrid, Biblioteca Nueva, 211-230.–(2000), “’Si los curas y frailes supieran…’ La violencia anticlerical”, en Juliá, S. (dir.), Violencia política en la España del siglo XX, Madrid, Taurus, 191-233.Cueva Merino, J. de la, y Montero García, F. (eds.) (2007), La secularización conflictiva. España (1898-1931), Madrid, Biblioteca Nueva.–(2009), Laicismo y catolicismo. El conflicto político-religioso en la segunda república, Alcalá de Henares, Universidad de Alcalá.De Baets, A. (2014), “The Year Zero: Iconoclastic breaks with the past”, Annales Universitatis Paedagogicae Cracoviensis Studia Politologica, 13, 3-18.Delgado, M. (2012), La ira sagrada. Anticlericalismo, iconoclastia y antirritualismo en la España contemporánea, Barcelona, RBA.Di Stefano, R. (2010), Ovejas negras. Historia de los anticlericales argentinos, Buenos Aires, Sudamericana.Durkheim, É. (2006 [1906]), “Determinación del hecho social”, en Sociología y filosofía, Buenos Aires, Schapire, 35-65.– (2008 [1912]), Las formas elementales de la vida religiosa, Alianza, Madrid.Davis, N. Z. (1993), “Los ritos de la violencia”, en Sociedad y cultura en la Francia moderna, Barcelona, Crítica, 149-185.Eliade, M. (1981 [1957]), Lo sagrado y lo profano, Madrid, Guadarrama.Freedberg, D. (2017), Iconoclasia. Historia y psicología de la violencia contra las imágenes, Vitoria-Buenos Aires, Sans Soleil Ediciones.Hubert, H, y Mauss, M. (2010 [1899]), “Ensayo sobre el sacrificio”, en Mauss, M., El sacrificio. Magia, mito y razón, Buenos Aires, Las Cuarenta.Gamboni, D. (2014), La destrucción del arte: iconoclasia y vandalismo desde la Revolución Francesa, Madrid, Cátedra.Garrisson Estebe, J. (1975), “The rites of violence: Religious riot in Sixteenth Century France”, Past & Present, 66, 127-150.Giobellina, F. (2014), El lado oscuro. La polaridad sagrado/profano en Durkheim y sus avatares, Buenos Aires, Katz.Girard, R. (1983), La violencia y lo sagrado. Anagrama, Barcelona.Gofmann, E. (2009 [1959]), La presentación de la persona en la vida cotidiana, Buenos Aires, Amorrortu.Goody, J. (1999), “¿Iconos e iconoclastia en África? Ausencia y ambivalencia”, en Representaciones y contradicciones, Barcelona, Paidós, 51-90.Grabar, A. (1998), La Iconoclastia bizantina, Madrid, Akal.Gruzinski, S. (2014), La Colonización de lo imaginario, México DF, FCE.Gumbrecht, H. U. (2005), Producción de presencia. Lo que el significado no puede transmitir, México DF, Universidad Iberoaméricana.Habermas, J. (2011), El poder de la religión en la esfera pública, Madrid, Trotta.Hermant, D. (1978), “Destructions et vandalisme pendant la Révolution française”, Annales ESC, 33 (4), 703-719.Hill, Ch. (2015), El mundo trastornado. El ideario popular extremista en la Revolución inglesa del siglo XVII, Madrid, Siglo XXI.La Parra López, E. y Suárez Cortina, M. (eds.) (1998), El anticlericalismo español contemporáneo, Madrid, Biblioteca Nueva.Lalouette, J. (1997), “El anticlericalismo en Francia, 1877-1914”, en Cruz, R. (ed.), El anticlericalismo, Madrid, Marcial Pons, (27), 15-38.Lannon, F. (1990), Privilegio, persecución y profecía. La iglesia católica en España, 1875-1975, Madrid, Alianza.Latour, B. (2002), “What is Iconoclash? or Is there a world beyond the image wars?”, en Weibel, P. y Latour, B., Iconoclash, Beyond the Image-Wars in Science, Religion and Art, Cambridge, ZKM and MIT Press, 14-37.Ledesma, J. L. (2005), “La ‘santa ira popular’ del 36: la violencia en guerra civil y revolución, entre cultura y política”, en Muñoz, J., Ledesma, J. L. y Rodrigo, J. (coords.), Madrid, Sierte Mares, 147-192.Leiris, M. (2007 [1931]), El África fantasmal. De Dakar a Yibuti, 1931-1933, Valencia, Pre-textos.Llobera, J. (1996), El dios de la modernidad. El desarrollo del nacionalismo en Europa occidental, Barcelona, Anagrama.Luther, M. (2012 [1529]), Grand Catéchisme, Florencia, Nabu Press.Mannelli, S. (2002), Anticlericalismo e democrazia: Storia del Partito radicale in Italia e a Roma, 1901–1914, Soveria Marelli, Rubbettimo.Martínez Assad, C. (1991), El laboratorio de la revolución. El Tabasco garridista, México DF, Siglo XXI.Mellor, A. (1967), Historia del anticlericalismo francés, Bilbao, Mensajero.Milhazes, J. (2012), “Comunismo como fase suprema do anticlericalismo”, Cultura, Espaço & Memória, 3, 63-78.Mitchell, T. J. (1988), Violence and Piety in Spanish Folklore, Minesotta, University of Pennsylvania Press.Mochizuki, M. M. (2006), The Netherlandish Image after Iconoclasm, 1566–1672. Material Religion in the Dutch Golden Age, Londres, Routledge.Otaola, J. (1999), Laicidad. Una estrategia para la libertad, Barcelona, Bellaterra.Otto, R. (1980 [1917]), Lo santo. Lo racional y lo irracional en la idea de Dios, Madrid, Alianza.Philipps, J. (1973), The Reformation of lmages: Destruction of Art in England, 1535-1600, Berkeley, University of Berkeley Press.Prades, J. A. (1998) Lo sagrado. Del mundo arcaico a la actualidad, Barcelona, Península.Radcliffe-Brown, A. R. (1996 [1939]), “Tabú”, en Estructura y función en la sociedad primitiva, Barcelona, Península, 153-173.Rambelli, F. y Reinders, E. (2012), Buddhism and Iconoclasm in East Asia: A History, Londres/Nueva York, Blombsbury.Ranzato, G. (1997), “Dies irae. La persecuzione religiosa nella zona republicana durante la guerra civile spagnola (1936-1939)”, en La difficile modernità e altri saggi sulla storia della Spagna contemporanea, Turín, Edizioni dell’Orso, 195-220.Reinders, E. (2004), “Monkey kings make havoc: iconoclasm and murder in the Chinese cultural revolution”, Religion, 34, 191-209.Ríos Figueroa, J. (2002), Siglo XX. Muerte y resurrección de la Iglesia Católica en Chiapas, San Cristóbal de las Casas, UNAM.Romero, P. G. (2002), El ojo de la batalla. Estudios sobre iconoclastia e iconodulia, historia del arte y vanguardia moderna, Valencia, Col·legi Major Rector Peset.Sansi, R. (2009), « Intenció i atzar en la historia del fetitxe », Quaderns de l’Institut Català d’Antropologia, 23 (8), 139-158.Sarró, R. (2009), The Politics of religious change on the Upper Guinea Coast: Iconoclasm done and undone, Edimburgo, Edinburgh University Press.Simmel, G. (1986 [1908]), “El secreto y la sociedad secreta”, en Sociología, Madrid, Alianza, vol. I, 357-424.Thomas, M. (2014), La Fe y la furia: violencia anticlerical popular e iconoclasta en España, 1931-1936, Granada, Comares.Tylor, R. P. (1985), The Death and the Resurrection Show. From Shamanism to Superstars, Londres, Blond.Ullman, J. C. (2009 [1968]), La Semana Trágica, Barcelona, Ediciones B.
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Sylwestrzak, Andrzej. "Artykuł recenzyjny „Słownika historii doktryn politycznych” wydanego przez Wydawnictwo Sejmowe, w sześciu tomach w latach 1997–2016." Czasopismo Prawno-Historyczne 69, no. 1 (October 4, 2018): 283–99. http://dx.doi.org/10.14746/cph.2017.1.13.
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Tom 1, litery A–C, pod red. M. Jaskólskiego, Warszawa 1997, ss. 457;Tom 2, litery D–H, pod red. M. Jaskólskiego, Warszawa 1999, ss. 473;Tom 3, litery I–Ł, pod red. M. Jaskólskiego, Warszawa 2009, ss. 660;Tom 4, litery M–Q, pod red. K. Chojnickiej i M. Jaskólskiego, Warszawa 2009, ss. 798;Tom 5, litery R–Ś, pod red. K. Chojnickiej i M. Jaskólskiego, Warszawa 2012, ss. 789;Tom 6, litery T–Ź, pod red. K. Chojnickiej i M. Jaskólskiego, Warszawa 2016, ss. 788
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Pich Mitjana, Josep, and David Martínez Fiol. "Manuel Brabo Portillo. Policía, espía y pistolero (1876-1919)." Vínculos de Historia. Revista del Departamento de Historia de la Universidad de Castilla-La Mancha, no. 8 (June 20, 2019): 387. http://dx.doi.org/10.18239/vdh_2019.08.20.
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RESUMEN:El objetivo del artículo es aproximarnos a la controvertida biografía del comisario Manuel Brabo Portillo. El trabajo está basado en fuentes primarias y secundarias. El método utilizado es empírico. En el imaginario del mundo sindicalista revolucionario, Brabo Portillo era el policía más odiado, la reencarnación de la cara más turbia del Estado. Fue, así mismo, un espía alemán relacionado con el hundimiento de barcos españoles, el asesinato del empresario e ingeniero Barret y el primer jefe de los terroristas vinculados a la patronal barcelonesa. La conflictividad que afectó a España en el período de la Primera Guerra Mundial es fundamental para entender los orígenes del terrorismo vinculado al pistolerismo, que marcó la historia político social española del primer tercio del siglo XX.PALABRAS CLAVE: Brabo Portillo, pistolerismo, espionaje, sindicalismo, Primera Guerra Mundial.ABSTRACT:The objective of the article is an approach to the controversial biography of Police Chief Manuel Brabo Portillo. The work is based on primary and secondary sources. The method used is empirical. In the imagery of the revolutionary syndicalist world, Brabo Portillo was the most hated policeman, the reincarnation of the murkiest face of the state. He was also a German spy connected with the sinking of Spanish ships, the murder of businessman and engineer Josep Barret and the first head of the terrorists linked to Barcelona employers. The conflict that affected Spain during the period of the First World War is fundamental in order to understand the origins of terrorism linked to pistolerismo, which marked Spanish social political history during the first third of the twentieth century.KEY WORDS: Brabo Portillo, pistolerismo, espionage, syndicalism, First World War. BIBLIOGRAFÍAAisa, M., La efervescencia social de los años 20. Barcelona 1917-1923, Barcelona, Descontrol, 2016.Aguirre de Cárcer, N., La neutralidad de España durante la Primera Guerra Mundial (1914-1918). I. Bélgica, Madrid, Ministerio de Asuntos Exteriores, 1995.Alonso, G., “’Afectos caprichosos’: Tradicionalismo y germanofilia en España durante la Gran Guerra”, Hispania Nova, 15, 2017, pp. 394-415.Amador, A., El Terror blanco en Barcelona. Las bombas y los atentados personales. Actuación infernal de una banda de asesinos al servicio de la burguesía. El asesinato como una industria, Tarragona, Talleres gráf. Gutenberg, [1920?].Anglés, C., “Contra los sindicatos. Los procesos de la organización obrera. La impostura nunca ha sido justicia”, Solidaridad Obrera, 836 (1/8/1918), p. 1.Balcells, A., El Pistolerisme. Barcelona (1917-1923), Barcelona, Pòrtic, 2009.Ben-Ami, S., La Dictadura de Primo de Rivera (1923-1930), Barcelona, Planeta, 1984.Bengoechea, S., Organització patronal i conflictivitat social a Catalunya. Tradició i corporativisme entre finals de segle i la dictadura de Primo de Rivera, Barcelona, PAM, 1994.Bengoechea, S., El locaut de Barcelona (1919-1920), Barcelona, Curial, 1998.Bengoechea, S., “1919: La Barcelona colpista. L’aliança de patrons i militars contra el sistema liberal”, Afers, 23/24 (1996), pp. 309-327.Brabo Portillo, M., Ensayo sobre policía científica, Barcelona, Gassó Hermanos, [190?].Bravo Portillo, M. y Samper, A., Programa para los exámenes de ingreso ó ascenso en plazas de oficiales de cuarta clase de la Hacienda Pública, Madrid, Mateu, 1906.Bueso, A., Recuerdos de un cenetista, Barcelona, Ariel, 1976.Burgos y Mazo, M. de, El verano de 1919 en Gobernación, Imprenta de E. Pinós-Cuenca, 1921.Calderón, F. de P. [Rico Ariza, E.] y Romero, I., Memorias de un terrorista. Novela episódica de la tragedia barcelonesa, Barcelona, [s.e.], [1924?].Carden, R. M., German Policy Toward Neutral Spain, 1914-1918, London, Routledge, 2014.Cardona, G., Los Milans del Bosch, una familia de armas tomar. Entre la revolución liberal y el franquismo, Barcelona, Edhasa, 2005.Casal Gómez, M., La Banda Negra. El origen y la actuación de los pistoleros en Barcelona (1918-1921), 2ª. Edición, Barcelona, Icaria, 1977.Calle Velasco, M. D. de la, “Sobre los orígenes del estado social en España”, Ayer, 25 (1997), pp. 127-150.D’Ors, E., “La unidad de Europa”, La Vanguardia, (1/12/1914), p. 7.Díaz Plaja, F., Francófilos y germanófilos. Los españoles en la guerra europea, Barcelona, Dopesa, 1973.Díez, P., Memorias de un anarcosindicalista de acción, Barcelona, Bellaterra, 2006.Domingo Méndez, R., “La Gran Guerra y la neutralidad española: entre la tradición historiográfica y las nuevas líneas de investigación”, Spagna Contemporanea, 34 (2008), pp. 27-44.Esculies, J., “España y la Gran Guerra. Nuevas aportaciones historiográficas”, Historia y Política, 32 (2014), pp. 47-70.Esdaile, Ch. J., La Quiebra del liberalismo, 1808-1939, Barcelona, Crítica, 2001.Foix, P., Los Archivos del terrorismo blanco. El fichero Lasarte (1910-1930), Madrid, Las Ediciones de la Piqueta, 1978.Forcadell, C., Parlamentarismo y bolchevización. 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Scher, Howard I., Karim Fizazi, Fred Saad, Mary-Ellen Taplin, Cora N. Sternberg, Kurt Miller, Ronald De Wit, et al. "Effect of MDV3100, an androgen receptor signaling inhibitor (ARSI), on overall survival in patients with prostate cancer postdocetaxel: Results from the phase III AFFIRM study." Journal of Clinical Oncology 30, no. 5_suppl (February 10, 2012): LBA1. http://dx.doi.org/10.1200/jco.2012.30.5_suppl.lba1.
Full textAbstract:
LBA1 Background: MDV3100, a novel androgen receptor signaling inhibitor (ARSI), competitively inhibits binding of androgens to the androgen receptor (AR), inhibits AR nuclear translocation, and inhibits association of the AR with DNA (Tran et al, Science. 2009;324:787). MDV3100 was selected for development based on activity in prostate cancer model systems with overexpressed AR, and was active in a phase I-II trial enrolling pre- and post-chemotherapy treated patients with progressive castration resistant disease (CRPC) (Scher et al, Lancet. 2010;375:1437). The AFFIRM trial evaluated whether MDV3100 could prolong overall survival (OS) in men with CRPC who progressed following docetaxel-based chemotherapy. Methods: In this randomized, double-blind, placebo-controlled, multinational phase III study ( NCT00974311 ), patients who had received ≤ 2 regimens of docetaxel-based chemotherapy were randomized 2:1 to MDV3100 160 mg/day or placebo. Treatment with corticosteroids was allowed but not required. Patients were stratified by baseline ECOG performance status and mean brief pain inventory score. The primary endpoint was OS. Other efficacy endpoints included radiographic progression-free survival (PFS), time to first skeletal-related event, time to prostate-specific antigen (PSA) progression, and circulating tumor cell count conversion rate. Results: 1,199 patients were randomized between Sep 2009 and Nov 2010. Based on a planned interim analysis at 520 death events, the Independent Data Monitoring Committee (IDMC) recommended the study be unblinded and placebo patients offered MDV3100 due to a significant OS benefit (p<0.0001; hazard ratio 0.631). The estimated median OS was 18.4 months for MDV3100 treated compared to 13.6 months for placebo treated men, a median OS difference of 4.8 months. Data to be available include PFS, time to PSA progression, and safety. Conclusions: MDV3100, a novel ARSI, significantly improves OS in men with postdocetaxel-treated CRPC reducing the risk of death by 37% relative to placebo. The IDMC determined the risk:benefit of MDV3100 was favorable and recommended the phase III AFFIRM trial be unblinded.
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Jain, Gaurav, Kristina Dzara, Mir Nadeem Mazhar, and Manisha Punwani. "Do regulated resident working hours affect medical graduate education? Trends in the American psychiatry board pass rates pre- and post-2003 duty hours regulations." Psychiatric Bulletin 38, no. 6 (December 2014): 299–302. http://dx.doi.org/10.1192/pb.bp.113.046292.
Full textAbstract:
Aims and methodTo assess trends of the American Board of Psychiatry and Neurology examination pass rates before and after the 2003 duty hours regulations (DHR). We obtained the pass rates for part I and II for years 2000–2010. Data were divided pre-DHR (2000–2003) and post-DHR (2007–2010).ResultsDuring the pre-DHR period, first- and multiple-attempt group pass rates were 80.7% and 39.0% which changed in the post-DHR period to 89.7% and 39.1% respectively. Similarly for the part II exam, the pre-DHR first- and multiple-attempt group pass rates were 60.2% and 43.5% respectively, which increased to 78.7% and 53.8%, among the post-DHR group. Overall, there was a significant increase in the first-attempt candidates pass rates for parts I and II, whereas multiple-attempt candidates did not benefit as strongly.Clinical implicationsThe results suggest that the 2003 DHR may have had a positive impact on examination-based medical knowledge in psychiatry.
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Bernardo, Cristiane Hengler Corrêa, Sergio Silva Braga Júnior, Mauricio Dias Marques, Silvia Cristina Vieira Gomes, and Timóteo Ramos Queiroz. "Percepção dos produtores rurais de Tupã, SP, sobre o processo de comunicação para execução da logística reversa de embalagens de agrotóxicos." Revista Observatório 1, no. 3 (December 26, 2015): 242. http://dx.doi.org/10.20873/uft.2447-4266.2015v1n3p242.
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Disponível em: O artigo objetivou identificar a percepção de produtores rurais de Tupã/SP sobre a legislação que implantou e regulamenta a logística reversa de embalagens de agrotóxicos, bem como as informações que têm sobre sua obrigação. Buscou-se trazer elementos contidos na legislação e considerações de diversos autores, por meio de pesquisa bibliográfica, assim como foi aplicado um formulário com 19 questões, sobre o comportamento de 20 produtores rurais frente às informações relativas à devolução das embalagens vazias de agrotóxicos. As discussões revelam que cerca de 60% dos respondentes são indiferentes, conhecem muito pouco ou desconhecem sua responsabilidade como primeiro elo da cadeia da logística reversa das embalagens vazias de agrotóxicos, talvez em virtude de falhas no processo de comunicação e na fiscalização. Sugere-se que deva haver maior empenho do Poder Público com vistas a intensificar a fiscalização e tornar mais compreensível as responsabilidades desses agricultores.PALAVRAS-CHAVE: Logística reversa, comunicação e agronegócios, embalagens vazias de agrotóxicos, legislação ambiental. ABSTRACTWith the purpose to identify the perception of farmers Tupa/SP on legislation that established and governs the reverse logistics of empty pesticide containers, as well as the information they have on their obligation. It sought to bring elements contained in the legislation and considerations of various authors, through literature, as well as a form with 19 questions about the behavior of 20 farmers in the face of information on the release of empty containers of pesticides were applied. The discussions show that about 60% of respondents are indifferent, know little or unaware of their responsibility as first link in the chain of reverse logistics of empty pesticide containers, perhaps because of flaws in the communication process and inspection. It is suggested that there should be greater commitment from the Government in order to step up surveillance and make more understandable the responsibilities of farmers.KEYWORDS: Reverse logistics, communications and agribusiness, empty pesticide containers environmental legislation. RESUMENCon el propósito de identificar la percepción del agricultor Tupa / SP en la legislación que estableció y administra la logística inversa de los envases vacíos de plaguicidas, así como la información que tienen sobre su obligación. Se intentó traer elementos contenidos en la legislación y las consideraciones de diversos autores, a través de la literatura, así como un formulario con 19 preguntas sobre el comportamiento de los 20 agricultores en la cara de la información sobre la liberación de los envases vacíos de plaguicidas se aplicaron. Los debates muestran que alrededor del 60% de los encuestados son indiferentes, saben poco o conscientes de su responsabilidad como primer eslabón de la cadena de la logística inversa de los envases vacíos de plaguicidas, tal vez debido a fallas en el proceso de comunicación e inspección. Se sugiere que debe haber un mayor compromiso del Gobierno con el fin de intensificar la vigilancia y hacer más comprensibles las responsabilidades de los agricultores.PALABRAS CLAVE: Logística inversa, las comunicaciones y la agroindustria, los envases de plaguicidas vacíos de la legislación ambiental. ReferênciasAnonymous. IBGE investiga o meio ambiente de 5.560 municipios brasileiros. 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Dá nova redação a dispositivos do Decreto no 98.816, de 11 de janeiro de 1990, que dispõe sobre a pesquisa, a experimentação, a produção, a embalagem e rotulagem, o transporte, o armazenamento, a comercialização, a propaganda comercial, a utilização, a importação, a exportação, o destino final dos resíduos e embalagens, o registro, a classificação, o controle, a inspeção e a fiscalização de agrotóxicos, seus componentes e afins. Disponível em < https://www.planalto.gov.br/ccivil_03/decreto/d3550.htm > Acesso em 12 mar. 2015.BRASIL. Decreto nº 3.694, de 21/12/2000. Altera e inclui dispositivos ao Decreto no 98.816 de 11 de janeiro de 1990, que dispõe sobre o controle e a fiscalização de agrotóxicos, e dá outras providências. Disponível em < http://www.planalto.gov.br/ccivil_03/decreto/D3694.htm > Acesso em 12 mar. 2015.BRASIL. Decreto nº 3.828, de 31/05/2001. Altera e inclui dispositivos ao Decreto no 98.816, de 11 de janeiro de 1990, que dispõe sobre o controle e a fiscalização de agrotóxicos e da outras providências. Disponível em < http://www.planalto.gov.br/ccivil_03/decreto/2001/D3828.htm > Acesso em 12 mar. 2015BRASIL. Decreto nº 4.074, de 04/01/2002. Regulamenta a Lei nº 7.802, de 11 de julho de 1989. Disponível em < https://www.planalto.gov.br/ccivil_03/decreto/2002/d4074.htm> Acesso em 12 mar. 2015.BRASIL. Decreto nº 98.816, de 11/01/1990. Regulamenta a Lei 7.802/1989 e dá outras providências. Disponível em < https://www.planalto.gov.br/ccivil_03/decreto/antigos/d98816.htm> Acesso em 12 mar. 2015.BRASIL. Lei Federal nº 12.305, de 02/08/2010. Institui a Política Nacional de Resíduos Sólidos; altera a Lei no 9.605, de 12 de fevereiro de 1998; e dá outras providências. Disponível em < http://www.planalto.gov.br/ccivil_03/_ato2007-2010/2010/lei/l12305.htm> Acesso em 05 set. 2014.BRASIL. Lei nº 6.938, de 31/08/1981. Dispõe sobre a Política Nacional do Meio Ambiente, seus fins e mecanismos de formulação e aplicação, e dá outras providências. Disponível em < http://www.planalto.gov.br/ccivil_03/leis/l6938.htm > Acesso em 04 set. 2014.BRASIL. Lei nº 7.802/1989, de 11/07/1989. Dispõe sobre a pesquisa, a experimentação, a produção, a embalagem e rotulagem, o transporte, o armazenamento, a comercialização, a propaganda comercial, a utilização, a importação, a exportação, o destino final dos resíduos e embalagens, o registro, a classificação, o controle, a inspeção e a fiscalização de agrotóxicos, seus componentes e afins, e dá outras providências. Disponível em https://www.planalto.gov.br/ccivil_03/leis/l7802.htm Acesso em 03 fev. 2015.BRASIL. Lei nº 9.605, de 12/02/1998. Dispõe sobre as sanções penais e administrativas derivadas de condutas e atividades lesivas ao meio ambiente, e dá outras providências. Disponível em < http://www.planalto.gov.br/ccivil_03/leis/l9605.htm > Acesso em 27 mar. 2015.BRASIL. Lei nº 9.974, de 06/06/2000. Altera a Lei nº 7.802/1989, que dispõe sobre a pesquisa, a experimentação, a produção, a embalagem e rotulagem, o transporte, o armazenamento, a comercialização, a propaganda comercial, a utilização, a importação, a exportação, o destino final dos resíduos e embalagens, o registro, a classificação, o controle, a inspeção e a fiscalização de agrotóxicos, seus componentes e afins, e dá outras providências. Disponível em < http://www.planalto.gov.br/ccivil_03/leis/L9974.htm> Acesso em 12 mar. 2015.BRASIL. Resolução CONAMA nº 334, de 3 de abril de 2003. Dispõe sobre os procedimentos de licenciamento ambiental de estabelecimentos destinados ao recebimento de embalagens vazias de agrotóxicos. Disponível em < http://www.mma.gov.br/port/conama/legiabre.cfm?codlegi=356> Acesso em 20 mar. 2015.BRASIL. Resolução CONAMA nº 465, de 05/12/2014. Dispõe sobre os requisitos e critérios técnicos mínimos necessários para o licenciamento ambiental de estabelecimentos destinados ao recebimento de embalagens de agrotóxicos e afins, vazias ou contendo resíduos. Disponível em < http://www.mma.gov.br/port/conama/legiabre.cfm?codlegi=710> Acesso em 20 mar. 2015.CANTOS, Clotilde; MIRANDA, Zoraide Amarante I.; LICCO, Eduardo Antonio. Contribuições para a Gestão das Embalagens Vazias de Agrotóxicos. ©INTERFACEHS - Revista de Gestão Integrada em Saúde do Trabalho e Meio Ambiente - v.3, n.2, Seção Interfacehs 1, abr./ agosto. 2008 www.interfacehs.sp.senac.br.CARBONI, Gleriani Torres; SATO, Geni Satiko; MOORI, Roberto Giro. Logística Reversa para Embalagens de Agrotóxicos no Brasil: Uma Visão sobre Conceitos e Práticas Operacionais. XLIII CONGRESSO DA SOBER "Instituições, Eficiência, Gestão e Contratos no Sistema Agroindustrial". Ribeirão Preto, 24 a 27 de Julho de 2005.COMETTI, José Luís Said. Logística reversa das embalagens de agrotóxicos no Brasil: um caminho sustentável?. 2009. 152 f., il. Dissertação (Mestrado em Desenvolvimento Sustentável)-Universidade de Brasília, 2009.COSTA, Evandro. Política Nacional de Resíduos Sólidos / Logística Reversa. SIRECOM - Sindicato dos Representantes Comerciais do Paraná. Disponível em http://sirecompr.org.br/noticia/274/politica-nacional-de-residuos-solidos---logistica-reversa. Acesso em 03 set.2014.FARIA, Ana Cristina de; PEREIRA, Raquel da Silva. O Processo de Logística Reversa de Embalagens de Agrotóxicos: um estudo de caso sobre o INPEV. Organizações Rurais & Agroindustriais, Lavras, v. 14, n. 1, p. 127-141, 2012.GIL, Antonio Carlos. Métodos e Técnicas de Pesquisa Social. 6 ed. São Paulo: Atlas, 2014.GRUTZMACHER, Douglas Daniel et al. Embalagens Vazias de Agrotóxicos: organização dos fabricantes e suas obrigações (Lei Federal 9.974). R. Bras. Agrociência, Pelotas, v. 12, n. 1, p. 05-06, jan-mar, 2006.HAIR Jr, J. F.;MONEY, A. H.; BABIN, B.; SAMOUEL, P. Fundamentos de Metodos de Pesquisa Em Administraca. Bookman, 2005.LADEIRA, Wagner Junior; MAEHLER, Alisson Eduardo; NASCIMENTO, Luís Felipe Machado do. Logística reversa de defensivos agrícolas: fatores que influenciam na consciência ambiental de agricultores gaúchos e mineiros. Revista de Economia e Sociologia Rural, v. 50, n. 1, p. 157-174, 2012.LEITE, Paulo Roberto. Logística Reversa - Nova área da logística empresarial. Revista Tecnologística, maio/2002. São Paulo, Edit. Publicare.MARCONI, M.A.; LAKATOS, E.M. Metodologia Científica. 6.ed.São Paulo: Atlas, 2011.MARCONI, Marina de Andrade; LAKATOS, Eva Maria. Técnicas de Pesquisa. 7 ed. São Paulo: Atlas, 2010.MAZZA, V.M.D.S. et al. Gestão de Resíduos Sólidos em Propriedades Rurais de Municípios do Interior do Estado do Rio Grande do Sul. Revista em Agronegócio e Meio Ambiente, Maringá, v. 7, n. 3, p. 683-706, Sep 2014.MELO, Wederson Miranda et al. Logística Reversa de Embalagens de Agrotóxicos: um estudo de caso na cidade de Patos-MG. VIII Congresso Nacional de Excelência em Gestão, 8 e 9 de junho de 2012. ISSN 1984-9354.MILLER, Chad R.; SARDER, M. D. Public works policy implications of sustainable reverse logistics operations. Public Works Management & Policy, p. 1087724X11429044, 2011.MOTTA, Wladmir Henriques. Análise do Ciclo de Vida e Logística Reversa. X SEGeT 2013 Simpósio de Excelência em Gestão e Tecnologia. Gestão e Tecnologia para a Competitividade. 23,24,25 out/2013.MOURÃO, Renata Fernandes; SEO, Emília Satoshi Miyamaru. Logística reversa de lâmpadas fluorescentes. InterfacEHS Revista de Saúde, Meio Ambiente e Sustentabilidade. V. 7, N. 3, 2012.OLIVEIRA, Andréa Leda Ramos de; CAMARGO, Samira Gaiad Cibim de. Logística Reversa de Embalagens de Agrotóxicoss: identificação dos determinantes de sucesso. Interciencia, Caracas, v. 39, n. 11, p. 780-787, 11 2014.PESTANA, M. H.; GAGEIRO, J. N. Análise de dados para ciências sociais: a complementaridade do SPSS. 2003.SILVA, D.; LOPES, Evandro Luiz; BRAGA JUNIOR, S. S. Pesquisa Quantitativa: Elementos, Paradigmas e Definições. Revista de Gestão e Secretariado, v. 5, n. 1, p. 01-18, 2014.VEZZALI, F. Opiniao-A soja eleva risco de contaminacao de trabalhadores por agrotóxicos. Source: IPS. Noticias Financieras, Miami, p. 1, Jun 13 2006.VICTOR, P.T. Opiniao - Politica Nacional dos Residuos Solidos. Noticias Financieras, Miami Aug 24 2010.WOLF, S. A. Professionalization of agriculture and distributed innovation for multifunctional landscapes and territorial development. Agricultural Human Values, n. 25, p. 203-207, 2008. Disponível em:Url: http://opendepot.org/2708/ Abrir em (para melhor visualização em dispositivos móveis - Formato Flipbooks):Issuu / Calameo
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Rauw, Jennifer, Richard A. Wells, Alden Chesney, Marciano D. Reis, and Rena Buckstein. "Validation of a Scoring System to Establish the Pretest Probability of Myelodysplastic Syndrome in Patients with Unexplained Cytopenias or Macrocytosis." Blood 114, no. 22 (November 20, 2009): 1761. http://dx.doi.org/10.1182/blood.v114.22.1761.1761.
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Abstract Abstract 1761 Poster Board I-787 Introduction Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis culminating in peripheral blood cytopenias and a propensity to Acute Myelogenous Leukemia (AML). The gold standard diagnostic test is the bone marrow aspirate and biopsy but clinicians are often hesitant to refer patients with unexplained cytopenias or macrocytosis for this test. Consequently undiagnosed patients are deprived access to effective treatments. Previously (Buckstein et al., Leukemia Research 33 (2009) 1313–1318) we identified factors which were independently predictive of diagnosing MDS at the time of bone marrow, including; age, mean corpuscular volume (MCV), red cell distribution (RDW), and lactate dehydrogenase (LDH). In this current study, we set out to validate our findings and determine the sensitivity and specificity of our scoring system for routine clinical practise. Methods We reviewed all bone marrow reports conducted at a tertiary care center for the years (January through December) 2006–2008 inclusive. Our inclusion criteria included bone marrows done for unexplained cytopenias and/or macrocytosis. We excluded all outside consultative referrals and bone marrows done for staging or remission assessment in patients with pre-existing or strongly suspected hemato-lymphoid diagnoses. In cases where the patient had more than one bone marrow, only the most recent marrow was used. The bone marrows were reviewed by two experienced hematopathologists, and the diagnosis of MDS was made using the WHO and/or FAB classification systems. Marrows were classified as ‘confirmed MDS’, ‘suspected MDS’ or ‘Not MDS’. Electronic patient charts were reviewed to determine the age, MCV, LDH and RDW at the time of diagnostic bone marrow. A factor was considered positive if the age was > 65 or if its value exceeded the upper range of normal for our laboratory standards (MCV > 96 fl, LDH > 250 IU/L, RDW >14.5%). All patients for whom we had 4 recorded factors were then assigned a score that ranged from 0 to 4. We determined the distribution of scores within this population, and the sensitivity and specificity of this scoring method in predicting a histopathological diagnosis of MDS. Results Three-hundred and forty bone marrows met our inclusion criteria, and 289 (85%) had all four factors recorded at the time of diagnosis. The predictive ability of the MDS score is summarized in Table 1. The probability of diagnosing MDS increased from 8% with a score of 0 to 46% with a score of 3 or 4. A similar trend was seen when all 344 marrows were analysed. Our scoring system had high sensitivity (> 96%), when only one predictive factor was present and high specificity (96%) when 4 predictive factors were present at the time of diagnostic marrow. (Table 2) Conclusions In patients with unexplained cytopenias, or macrocytosis undergoing a diagnostic BM test, the pre-test probability of a MDS diagnosis increases as the number of predictive factors increases. The specificity of our MDS score also follows a similar trend. The sensitivity is high with only one positive factor indicating a lower score can be used as a screening tool. We have effectively validated a scoring system that may help clinicians decide on the utility of arranging diagnostic bone marrow examinations for patients with undiagnosed cytopenias and macrocytosis. Disclosures Buckstein: Celgene : Honoraria; Novartis: Honoraria.
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Imig, John D. "Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases." American Journal of Physiology-Renal Physiology 289, no. 3 (September 2005): F496—F503. http://dx.doi.org/10.1152/ajprenal.00350.2004.
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Renal epoxygenase metabolites are involved in blood flow regulation and long-term blood pressure control. One feature of renal and cardiovascular diseases is the inability of the kidney to properly increase epoxyeicosatrienoic acid (EET) levels. Others (Busse R, Edwards G, Félétou M, Fleming I, Vanhoutte PM, and Weston AH. Trends Phamacol Sci 23: 374–380, 2002; Campbell WB, Gebremedhin D, Pratt PF, and Harder DR. Circ Res 78: 415–423, 1996; Capdevila JH and Falck JR. Biochem Biophys Res Commun 285: 571–576, 2001; Roman RJ. Physiol Rev 82: 131–185, 2002; Zeldin DC. J Biol Chem 276: 36059–36062, 2001) and we (Imig JD, Falck JR, Wei S, and Capdevila JH. J Vasc Res 38: 247–255, 2001; Imig JD, Zhao X, Capdevila JH, Morisseau C, and Hammock BD. Hypertension 39: 690–694, 2002; Zhao X, Pollock DM, Inscho EW, Zeldin DC, and Imig JD. Hypertension 41: 709–714, 2003; Zhao X, Pollock DM, Zeldin DC, and Imig JD. Hypertension 42: 775–780, 2003) have provided compelling evidence that cytochrome P-450-derived EETs have antihypertensive properties and are endothelially derived hyperpolarizing factors (EDHFs) in the kidney. EETs also possess anti-inflammatory actions that could protect the kidney vasculature from injury during renal and cardiovascular diseases. A tactic that has been used to increase EET levels has been inhibition of the soluble epoxide hydrolase enzyme. Epoxide hydrolase inhibitors have been demonstrated to be antihypertensive and renal protective. Thus the renal and cardiovascular protective actions of increasing epoxygenase levels could be translated to therapies for preventing end-organ damage.
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Alexis, Hougni, Imorou Lucien, Dagoudo Augustin, and Zoumarou-Wallis Nouhoun. "Caractérisation Agro-Morphologique De Variétés De Cotonnier (Gossypium Hirsutum) Pour Une Régionalisation Economique Pour La Production Du Coton Au Bénin." European Scientific Journal, ESJ 12, no. 36 (December 31, 2016): 210. http://dx.doi.org/10.19044/esj.2016.v12n36p210.
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To take more account of the terroir effect in varietal choice and address the concerns of cotton farmers who disapprove the agricultural policy of single variety, research on varietal regionalization was initiated during four campaigns, by the Agricultural Research Center for Cotton Fibers. This idea is reinforced by the diversity of agro-ecological zones of the country. The nonrenewal of the variety in extension since the 2002-2003 campaign is also an element of justification concerns of industry players. This study aims to exploit the terroir effect to identify the most suitable varieties for each agroecological zone and meet the needs of industry players including producers and ginners. The experiment was conducted in 2011-2012 on Angaradébou sites, Okpara, Savalou and Ketou respectively representing the zones 1 (Alibori / Atakora); 2 (Borgou / Donga); 3 (Hills) and 4 (Zou / Ouemé Plateau / Mono-Couffo). The adopted experimental device is a Fisher block with four replicate and eight treatments or varieties H 279-1 in extension witness. Other varieties include E 944-2; E 956-2; H 769-5; H 782-3; I 875-3; K 768-3 and K 787-2.The measured parameters are the earliness of production, seed cotton yield in the field, the weight of 100 seeds and the fiber ginning outturn. Data analysis revealed significant differences between and inside sites for most measured parameters. The results showed that varieties E 956-2 (1983.85 kg / ha), H 769-5 (1820.49 kg / ha), K 768-3 (1735.42 kg / ha) and H 782-3 (1533.59 kg / ha) in terms of seed cotton yield in the field and compared their performance to shattering were the best respectively in zones 1, 2, 3 and 4.
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Al-Kali, Aref, Darci Zblewski, Adam C. Bartley, Mrinal M. Patnaik, Naseema Gangat, Kebede H. Begna, Ayalew Tefferi, et al. "Outcome of Myelodysplastic Syndromes over Time in the US: A National Cancer Data Base Study from 2004-2013." Blood 128, no. 22 (December 2, 2016): 3604. http://dx.doi.org/10.1182/blood.v128.22.3604.3604.
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Abstract Background: Over 10,000 new cases of myelodysplastic syndrome (MDS) are diagnosed in the US annually (MA X, Cancer 2007). Hypomethylating agents (azacitidine and decitabine), immunomodulating drugs (lenalidomide) and erythropoietin stimulating agents (epoetin α and darbepoetin) have been approved for more than a decade for the treatment of MDS. However, changes in overall outcome after the approval of these treatments are unknown. We used the National Cancer Data Base (NCDB), a nationwide oncology registry covering 70% of the US cancer population to answer these questions. Methods: We identified patients with MDS diagnosed from 2004-2013 using ICD-O-3 codes 9980-9983 and 9985-99912. Overall survival (OS) was estimated using the Kaplan-Meier method. We compared OS using the log-rank test according to demographic subgroups (sex, age [<40, 41-65, and ≥65 years], race [White, Black, Native American, Asian/Pacific Islander, and other], and ethnicity) across years of diagnosis (Period 1: 2004-2006, Period 2: 2007-2009, and Period 3: 2010-2013). Results: i) Characteristics: There were 54,953 MDS patients in our study. The median age at diagnosis was 76 years (78.7% older than 65) and 44% were females. White race (88.9%) was the most common, followed by black (7%). Four percent were Hispanics. A third (30.8%) of all patients were treated in academic centers. Three quarters (75.8%) had either Medicaid or Medicare insurance. ii) MDS Subtypes: 5q Syndrome was seen in 2008 cases (3.7%) while the most common subtype was MDS-Unclassifiable (U) (55.6%). Therapy related MDS (t-MDS) was seen in 1125 cases (2%), however coding for t-MDS was discontinued in 2009. Refractory anemia (RA), refractory anemia with ring sideroblasts (RARS), refractory cytopenia with multilineage dysplasia (RCMD), and refractory anemia with excess blasts were seen in 9%, 7.6%, 6%, and15.6%, respectively. iii) OS: Compared to their counterparts, patients who were male, older, had a diagnosis of RAEB, covered by Medicare insurance, and treated at non-academic centers had the worse OS (all P <0.001). Across Periods 1-3, we did not see improvement in OS among demographic subgroups except for those who were <40 years old (P=0.03). Conclusions: In the past decade, the overall outcome of MDS did not improve despite the advent of new therapies. More than half of the cases were classified as MDS-U reflecting the difficulty of subtyping MDS based on World Health Organization classification. We found disparity in outcomes by demographics and type of treatment facility. This is the largest study of MDS outcome to-date and should help in understanding the gaps and areas that need future research. Figure Figure. Disclosures Al-Kali: Onconova Therapeutics, Inc.: Research Funding; Celgene: Research Funding.
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Gugliotta, Luigi, Stefano Ascani, Silvia Asioli, Emanuela Boveri, G. Fraternali Orcioni, Umberto Gianelli, Elena Sabattini, et al. "Bone Marrow Biopsy Revision According to WHO Criteria in 272 Patients of the Registro Italiano Trombocitemia (RIT): Preliminary Report On Clinical and Histopathological Implications." Blood 114, no. 22 (November 20, 2009): 4974. http://dx.doi.org/10.1182/blood.v114.22.4974.4974.
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Abstract Abstract 4974 Background The bone marrow trephine biopsy (BMB) has a crucial role for the diagnosis of essential thrombocythemia (ET), both according to the PVSG and the WHO criteria. The WHO 2001 criteria enhanced the role of BMB also by distinguishing the true-ET (ET) from the prefibrotic and the early fibrotic chronic idiopathic myelofibrosis. The WHO 2008 criteria, in the JAK2 era, confirmed the diagnostic and prognostic relevance of the histopathological features in ET as well as in the other Ph-neg myeloproliferative neoplasms (MPN). Otherwise, only few validated data are presently available, and the reproducibility in the evaluation of some morphological details is still controversy. Objective To validate ET diagnosis in a large registry-based series of patients by revising the BMB specimens according to the WHO criteria and to evaluate the potential relationship between the histopathological and the clinical parameters at presentation. Methods The hematological centers of the Registro Italiano Trombocitemia (RIT) were invited to participate to this study by sending the BMB specimens (hematoxylin-eosin, Giemsa and silver stains) obtained at diagnosis. The clinic-pathological panel of the RIT (with three hematopathologists as permanent members coordinated by a chairman) performed a centralized revision of the BMB specimens, concomitantly (multiheaded microscopy) and blindly (only patient sex and age were known). The panel described for each case the morphological features and gave a diagnostic conclusion according to WHO criteria as follows: true-ET (ET); or initial primary myelofibrosis (i-PMF) distinguished in prefibrotic PMF (pf-PMF/MF-0) and early fibrotic PMF (ef-PMF/MF-1); or advanced PMF (MF-2 and MF-3); or early polycythemia vera (e-PV); or MPN unclassifiable (MPN-U); or diagnosis other than MPN (No MPN). Results Thirteen centers sent the specimen of BMB at diagnosis of 272 patients registered into the RIT and diagnosed in the years 1986-2002 (group A, cases 66, 24.3%), 2003-2005 (group B, cases 95, 34.9%) and 2006-2008 (group C, cases 111, 40.8%). The patients, 104 (38%) males and 168 (62%) females, had at diagnosis: age over 50 in 64% of cases (median 58); PLT count (109/L) >1000 in16% and <= 600 in 24% of cases (median 789); Hgb level (g/dL) >17 in 1% and <=9 in 5% of cases (median 14.3); WBC count (109/L) >9 in 44% of cases (median 8.6); splenomegaly in 18% of cases. Disease symptoms, thrombotic and hemorrhagic events were reported in 40%, 21%, and 7% of cases, respectively. During the follow-up (median 2.7 years) 65% of patients received cytoreductive drugs (Hydroxyurea 59%, Anagrelide 20%, Interferon 14%, Pipobroman 6.5%, Busulfan 0.5%). The revision of the 272 BMB specimens allowed to the following diagnosis: ET 142 cases, 52.2%; i-PMF 72 cases, 26.5% (distinguished in pf-PMF 19 cases, 7% and ef-PMF 53 cases, 19.5%); e-PV 13 cases, 4.8%; MPN-U 16 cases, 14.3%; No MPN 8 cases, 2.9%. In the patients of groups A, B, and C the rate of ET was increasing (from 44%, to 50% and to 59%, respectively) while the rate of i-PMF was decreasing (from 34%, to 31% and to 18%, respectively); moreover, the rate of e-PV was 0%, 6%, and 6%, respectively. The ET patients compared with the i-PMF patients showed at diagnosis a lower rate of splenomegaly (16/142, 11.3% vs 24/72, 33.3%, p<0.0001), of age >50 years ( 84/142, 59.2% vs 53/72, 73.6%, p<0.03), and a higher rate of PLT count (109/L) <=600 (39/142, 27.5% vs 11/72, 15,3%, p<0.04 ); no significant differences were found between the two groups for sex, Hgb level, WBC count, symptoms, thrombotic and hemorrhagic events. The treatment rate was lower in ET than in i-PMF (ratio 0.7). Conclusion This preliminary report on the revision of the BMB at diagnosis in 272 patients of the Registro Italiano Trombocitemia (RIT) shows that: the rate of true ET is continously increasing (from 44% before 2003 to 59% in the period 2006-2008), with i-PMF rate concomitantly decreasing (from 34% to 18%); the ET patients, compared with the i-PMF ones, were younger, with lower PLT count and with lower rate of splenomegaly, and received a less intensive cytoreductive treatment. Disclosures No relevant conflicts of interest to declare.
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Diabaté, Abidina, Jean Louis Zerbo, and Frédéric Ouattara. "Variation of the foF2 parameter during fluctuating activity: Prediction with IRI-2012 compared to measured data from Ouagadougou inosonde station during solar cycles 21 and 22." VIETNAM JOURNAL OF EARTH SCIENCES 41, no. 1 (January 8, 2019): 59–68. http://dx.doi.org/10.15625/0866-7187/41/1/13549.
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In this paper, we review on diurnal variations of the foF2 ionospheric parameter predicted by the IRI-2012 model, and data from Ouagadougou ionosonde station located in the crest of the Equatorial Anomaly (Lat: 12.5°N; Long: 358.5°E, dip: 1.43°) during fluctuating geomagnetic activity conditions for the solar cycles 21 and 22. Our investigations are focused on the electrodynamic aspects, the influence of the ionospheric electric currents as well as the variations of the hourly values given by model and experimental measurements. A comparative study pointed out that the IRI-2012 model, through its URSI and CCIR subroutines, gives a good prediction of the critical frequency of the F2 layer between 0700 TL and 0000 TL. In addition, IRI -2012 tries to reproduce, as best as possible, the vertical drift E × B during minimum, decreasing phase, winter, and autumn. However, there is no effect of drift during the other seasons and solar cycle phases. A last, the model does not take into account the PRE phenomenon observed in autumn and the influence of the equatorial electrojet in this ionospheric zone.ReferencesAcharya R., Roy B., Sivaraman M.R., 2010. Dasgupta A. An empirical relation of daytime equatorial total electron content with equatorial electrojet in the Indian zone. J Atmos Terr Phys, 72(10), 774–780.Acharya R., Roy B., Sivaraman M.R.; Dasgupta A., 2011. On conformity of the EEJ based Ionospheric model to the Fountain effect and resulting improvements. J Atmos Terr Phys, 73, 779-784.Adeniyi J.O., Oladipo O.A., Radicella S.M., 2005. Variability of fof2 and comparison with iri model for an equatorial station. The Abdus Salam International Centre for Theoretical Physics, IC/2005/085, http://www.ictp.it/~pub_off.Adeniyi1 J.O., Oladjipo O.A., Radicella S.M., 2005. Variability of foF2 and comparison with IRI model for an equatorial station. The Abdus Salam International Centre for Theoretical Physics, IC/2005/085.Bilitza D., et al., 2014. The International Reference Ionosphere 2012-a model of international collaborationI. J. Space Weather Space Clim, 4, A07.Bilitza D., Reinisch B.W., 2008. International Reference Ionosphere 2007: Improvements and new parameters. Adv. Space Res, 42, 599–609.Farley D.T., Bonell E., Fejer B.G., Larsen M.F., 1986. The Prereversal Enhancement of the Zonal Electric Field in the Equatorial Ionosphere. J Geophys Res, 91(A12), 13,723–13,728.Faynot J.M., Villa P., 1979. F region at the magnetic equator. Ann Geophys, 35, 1–9.Fejer B.G., 1981. The equatorial ionospheric electric fields: A review. J Atmos Terr Phys, 43, 377.Fejer B.G., Farley D.T., Woodman R.F., Calderon C., 1979. Dependence of equatorial F region vertical drifts on season and solar cycle. J Geophys Res, 84, 5792.Legrand J.P., Simon P.A., 1989. Solar cycle and geomagnetic activity: A review for geophysicists. Part I. The contributions to geomagnetic activity of shock waves and of the solar wind. Ann. Geophys, 7, 565–578.Obrou K.O., 2008. Contribution à l’amélioration du modèle "International Reference Ionosphere" (IRI) pour l’ionosphère équatoriale. Thèse de doctorat Université de Cocody, Abidjan, Côte d’Ivoire.Ouattara F., 2009. Contribution à l’étude des relations entre les deux composantes du champ magnétique solaire et l’Ionosphère Equatoriale. Thèse de Doctorat d’Etat ès Sciences, Université Cheikh Anta Diop, Dakar, Sénégal.Ouattara F., 2013. IRI-2007 foF2 Predictions at Ouagadougou Station during Quiet Time Periods from 1985 to 1995. Archives of Physics Research, 4, 12–18.Ouattara F., Amory-Mazaudier C., 2009. Solar–geomagnetic activity and Aa indices toward a Standard. J. Atmos. Terr. Phys, 71, 1736–1748.Ouattra F., Nanéma, 2014. Quiet Time foF2 Variation at Ouagadougou Station and Comparison with TIEGCM and IRI-2012 Predictions for 1985 and 1990. Physical Science International Journal, 4(6), 892–902.Oyekola O.S., Fagundes P.R., 2012. Equatorial F2-layer variations: Comparison between F2 peak parameters at Ouagadougou with the IRI-2007 model. Earth, Planets Space, 64, 553–566.Rishbeth H., 1971. The F-layer dynamo. Planet, Space Sci, 19, 263.Vassal J.A., 1982. The variation of the magnetic field and its relationship with the equatorial electrojet in Senegal Oriental. Annals of Geophysics, Tome French, 38.Zerbo J.L., Amory-Mazaudier C. Ouattara F., Richardson J., 2012. Solar Wind and Geomagnetism, toward a Standard Classification 1868-2009. Ann Geophys, 30, 421–426. http://dx.doi.org/10.5194/angeo-30-421-2012.Zerbo J.L., Amory-Mazaudier C., Ouattara F., 2013. Geomagnetism during solar cycle 23: Characteristics. J. Adv. Res, 4(3), 265–274. Doi:10.1016/j.jare.2013.08.010.Zerbo J.L., Ouattara F., Zoundi C., Gyébré A., 2011. Solar cycle 23 and geomagnetic activity since 1868. Revue CAMES serie A, 12(2), 255–262.
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Sokov, A. V., and N. A. Rimsky-Korsakov. "IN MEMORY OF THE TECHNICAL GENIUS IGOR’ EVGENIEVICH MIKHALTSEV (1923–2010)." Journal of Oceanological Research 51, no. 3 (November 9, 2023): 159–65. http://dx.doi.org/10.29006/1564-2291.jor-2023.51(3).8.
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The article is dedicated to the 100th anniversary of the birth of Igor’ Evgenievich Mikhaltsev – oceanologist, Doctor of Technical Sciences (1970), Professor (1971), from 1989 to 2006 – Head of the Laboratory of Exploratory Technical Research of the Shirshov Institute of Oceanology of Russian Academy of Sciences (IO RAS). Mikhaltsev – the creator of a new direction in technical oceanology – a comprehensive experimental study of ocean acoustics, including acoustic methods for studying the ocean, head of work on the creation and testing of manned research vehicles “Pisces” up to 2000 m (1970–1976) and manned vehicles “MIR” – up to 6000 m (1979–1987). Hero of Socialist Labor. The material was prepared on the basis of biographical data and photographs according to sources: IO RAS website https:// ocean.ru/index.php/component/k2/item/782-mikhaltsev-igor-evgenevich-1923-2010; Journal “Nostalgiya” No. 10, 2007. Article by I. Mikhaltsev “Science should be a hobby”. Also in this issue of our “Journal of Oceanological Research” you will find an article by I. E. Mikhaltsev himself, “Ocean research, technology, fleet: yesterday, today, tomorrow”.
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Fernández Puertas, Antonio. "II. Mezquita de Córdoba. ‘Abd al-Raḥmān I (169/785-786). El trazado proporcional de la planta y alzado de las arquerías del oratorio. La qibla y el miḥrāb del siglo VIII." Archivo Español de Arte 81, no. 324 (December 30, 2008): 333–56. http://dx.doi.org/10.3989/aearte.2008.v81.i324.127.
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KLEWICKI, J., R. EBNER, and X. WU. "Mean dynamics of transitional boundary-layer flow." Journal of Fluid Mechanics 682 (July 19, 2011): 617–51. http://dx.doi.org/10.1017/jfm.2011.253.
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The dynamical mechanisms underlying the redistribution of mean momentum and vorticity are explored for transitional two-dimensional boundary-layer flow at nominally zero pressure gradient. The analyses primarily employ the direct numerical simulation database of Wu & Moin (J. Fluid Mech., vol. 630, 2009, p. 5), but are supplemented with verifications utilizing subsequent similar simulations. The transitional regime is taken to include both an instability stage, which effectively generates a finite Reynolds stress profile, −ρuv(y), and a nonlinear development stage, which progresses until the terms in the mean momentum equation attain the magnitude ordering of the four-layer structure revealed by Wei et al. (J. Fluid Mech., vol. 522, 2005, p. 303). Self-consistently applied criteria reveal that the third layer of this structure forms first, followed by layers IV and then II and I. For the present flows, the four-layer structure is estimated to be first realized at a momentum thickness Reynolds number Rθ = U∞ θ/ν ≃ 780. The first-principles-based theory of Fife et al. (J. Disc. Cont. Dyn. Syst. A, vol. 24, 2009, p. 781) is used to describe the mean dynamics in the laminar, transitional and four-layer regimes. As in channel flow, the transitional regime is marked by a non-negligible influence of all three terms in the mean momentum equation at essentially all positions in the boundary layer. During the transitional regime, the action of the Reynolds stress gradient rearranges the mean viscous force and mean advection profiles. This culminates with the segregation of forces characteristic of the four-layer regime. Empirical and theoretical evidence suggests that the formation of the four-layer structure also underlies the emergence of the mean dynamical properties characteristic of the high-Reynolds-number flow. These pertain to why and where the mean velocity profile increasingly exhibits logarithmic behaviour, and how and why the Reynolds stress distribution develops such that the inner normalized position of its peak value, ym+, exhibits a Reynolds number dependence according to $y_m^+ {\,\simeq\,} 1.9 \sqrt{\delta^+}$.
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da Empoli, Domenico. "Monti, A. - Briganti, A. (eds), 2002, Rapporto sull’istruzione universitaria in Italia – I costi e i rischi delta riforma,." Journal of Public Finance and Public Choice 20, no. 1 (April 1, 2002): 77–79. http://dx.doi.org/10.1332/251569202x15665366114860.
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Raposo, Marcos Túlio, and Maria Ines Battistella Nemes. "Assessment of integration of the leprosy program into primary health care in Aracaju, state of Sergipe, Brazil." Revista da Sociedade Brasileira de Medicina Tropical 45, no. 2 (April 2012): 203–8. http://dx.doi.org/10.1590/s0037-86822012000200013.
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INTRODUCTION: The aim of this study was to assess the epidemiological and operational characteristics of the Leprosy Program before and after its integration into the Primary healthcare Services of the municipality of Aracaju-Sergipe, Brazil. METHODS: Data were drawn from the national database. The study periods were divided into preintegration (1996-2000) and postintegration (2001-2007). Annual rates of epidemiological detection were calculated. Frequency data on clinico-epidemiological variables of cases detected and treated for the two periods were compared using the Chi-squared (χ2) test adopting a 5% level of significance. RESULTS: Rates of detection overall, and in subjects younger than 15 years, were greater for the postintegration period and were higher than rates recorded for Brazil as a whole during the same periods. A total of 780 and 1,469 cases were registered during the preintegration and postintegration periods, respectively. Observations for the postintegration period were as follows: I) a higher proportion of cases with disability grade assessed at diagnosis, with increase of 60.9% to 78.8% (p < 0.001), and at end of treatment, from 41.4% to 44.4% (p < 0.023); II) an increase in proportion of cases detected by contact examination, from 2.1% to 4.1% (p < 0.001); and III) a lower level of treatment default with a decrease from 5.64 to 3.35 (p < 0.008). Only 34% of cases registered from 2001 to 2007 were examined. CONCLUSIONS: The shift observed in rates of detection overall, and in subjects younger than 15 years, during the postintegration period indicate an increased level of health care access. The fall in number of patients abandoning treatment indicates greater adherence to treatment. However, previous shortcomings in key actions, pivotal to attaining the outcomes and impact envisaged for the program, persisted in the postintegration period.
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MURDY, EDWARD O. "Corrections and clarifications to the descriptions of Biendongella and Sovvityazius (Perciformes: Gobiidae)." Zootaxa 4276, no. 1 (June 9, 2017): 127. http://dx.doi.org/10.11646/zootaxa.4276.1.7.
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Prokofiev (2015a) described two new genera and species of Amblyopinae and reported new amblyopine records from waters off Indonesia, the Philippines, and Vietnam. In reviewing Prokofiev’s figures and reading the descriptions of his new genera, Biendongella Prokofiev, 2015 and Sovvityazius Prokofiev, 2015, it appeared likely that these new taxa were based on species also under examination by Koichi Shibukawa and me. However, some differences existed between our specimens and those described by Prokofiev in the pterygiophore formula (DF), the presence/absence of hypural 5, and the number of epurals. The data and information on these characters were not abundantly clear from the text and clarification was needed. For example, on page 786 of Prokofiev (2015a) the following diagnostic feature of Biendongella was provided, “DF 3 1221, vacant interneural gap between spined and soft parts of D present; two first pterygiophores of soft part of D each located in its interneural gap…”. Similar wording exists for Sovvityazius on page 789, “DF 3 1221, vacant gap between spined and soft parts of D present; two first pterygiophores of soft part of D each in its interneural space…”. As for hypural 5 and the number of epurals, the same statement is given for both Biendongella and Sovvityazius on pages 786 and 789, respectively, “Hypural 5 and epural 2 absent.” These character states struck me as remarkable as they are atypical for amblyopines. With respect to the DF character above, amblyopine gobies with a pterygiophore formula of 3-1221 have no interneural gap and the interneural space immediately posterior to the pterygiophore of the ultimate spinous ray contains two pterygiophores (Murdy 2011). As for the latter characters, hypural 5 and two epurals are present in amblyopine gobies (Shibukawa and Murdy 2012). In a detailed email to Prokofiev, I asked for clarification of these discrepancies and whether Biendongella and Sovvityazius have the amblyopine synapomorphy of the ultimate pterygiophore supporting a single ray (Murdy & Shibukawa 2001), which was not mentioned in the description of either genus.
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Wulff, Karin, Jan Astermark, Falko F. H. Herrmann, Günther Auerswald, and Winnie Schröder. "Characterization of a Novel Aberrant Splice Site, 79bp Downstream of Exon 5 in the Human Factor 7 Gene Detected in Patients with Severe Congenital Factor VII Deficiency." Blood 114, no. 22 (November 20, 2009): 3481. http://dx.doi.org/10.1182/blood.v114.22.3481.3481.
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Abstract Abstract 3481 Poster Board III-418 Hereditary FVII deficiency (FVIID) is a rare congenital bleeding disorder with an estimated prevalence of symptomatic individuals of 1:500,000. In the “Greifswald Registry FVII Deficiency” molecular defects of more than 1000 FVII deficient patients were described. By direct sequencing of the F7 genes in congenital FVIID revealed 146 different F7 gene mutations including 25 different mutations (18% of all) in the naturally-occurring acceptor or donor splice sites (Tab.1) were identified. In seven FVIID patients from Sweden and Germany the novel lesion g.IVS5+78G>A - downstream of the naturally-occurring donor splice sites of exon 5 - was identified. This variation was detected heterozygous in FVIID patients with FVII: C levels of 15%, 27%, 31%, 40% and 65%, and FVII: Ag levels between 25-50%. In two compound heterozygous patients with FVII: C levels of 1% und FVII: Ag levels of 2% and 3% respectively, one well-known causative FVII mutation is combined with the novel lesion g.IVS5+78G>A. The influence of this novel F7 gene variation on splicing was investigated by RT-PCR analysis and in vitro expression studies using exon-trap vector constructs. The total RNA was isolated from peripheral leucocytes and analyzed by one step RT-PCR and sequencing. Fragments of exon 5 and a part of the flanking intron 5 region (g.7679 –g.8073) were amplified of patients' DNA and cloned into the exon trap-vector pET01. Different vector constructs containing minigenes of the wild type (g.IVS5+78G) or mutant form (g.IVS5+78A) and the corresponding minigenes with an “optimized” naturally-occurring donor splice site in position +5 respectively were transfected into HEK293 cells. The expressed RNA was isolated and characterized. Consensus Values (CV) for all donor splice sites were calculated using a splice site detection tool according Shapiro and Senapathy (1987). The RT-PCR analysis in patients indicate that the novel variation g.IVS5+78G>A in intron 5 created an aberrant splice site in position 79bp downstream of exon 5 even though the naturally-occurring donor-splice-site of exon 5 is not abolished. An insertion of 79bp of intron 5 into the mRNA leads to a frame shift and predicts a premature termination 11 codons past the last unaltered codon. Minigenes include the naturally-occurring splice site and the variation g.IVS5+78A used exclusively the aberrant splice position 79bp downstream of exon 5 whereas wild type minigenes with the naturally-occurring splice site and the wild type form g.IVS5+78G produced normally spliced mRNA. In a following experiment the “naturally-occurring splice site” of exon 5 was optimized by the additional substitution g.IVS5+5C>G which increased their CV from 76.6 to 90.9 compared to the CV of the novel mutant g.IVS5+78A of 80.3. In presence of both mutations (g.IVS5+5G and g.IVS5+78A) only normal spliced mRNA was expressed of this minigene. In this construct the mutation g.IVS5+78G>A was without importance for the mRNA splicing. The results of the in vitro experiments demonstrated, that the Consensus Values (CV) seems to be an important factor for the selection of donor splice sites in the F7 gene. In the “Greifswald Registry FVII Deficiency” 26 different splice site variations in F7 gene were identified (Tab. 1). The atypical splice site variation g.IVS5+78G>A, +78bp downstream of exon 5 was present in 7 FVIID patients from Sweden and Germany in different genotypes. This novel F7 gene mutation g.IVS5+78G>A creates an aberrant splice site in position +79 of intron 5 and predicts premature termination. RNA analysis and expression studies demonstrated, that this novel F7 gene lesion is a type I mutation with low FVII:C and FVII: Ag levels and is the basis defect in 7 FVIID patients of the “Greifswald Registry FVII Deficiency”. Tab. 1 26 different intronic F7 gene mutations analysed in FVII deficiency patients of the “Greifswald Registry FVII Deficiency” Intron Acceptor splice site Intron Donor splice site 1b g.IVS1b-11G>A 1a g.IVS1a+5G>A 1b *g.IVS1b8del14bp 1a *g.IVS1a+6T>G 1b *g.IVS1b-3C>G 1a *g.IVS1a+8C>T 2 *g.IVS2-3C>G 2 g.IVS2+1G>A 3 g.IVS3-1G>A 2 *g.IVS2+1G>T 3 *g-IVS3-1G>T 2 *g.IVS2+1G>C 4 *g.IVS4-7T>G 2 *g.IVS2+1delG 7 *g.IVS7-10T>C 2 g.IVS2+5G>T 7 *g.IVS7-3C>G 3 *g.IVS3+1G>T 7 *g.IVS7-1G>A 4 g.IVS4+1G>A 5 *g.IVS5+78G>A 6 *g.IVS6+1G>A 6 g.IVS6+1G>T 6 *g.IVS6+3A>G 7 *g.IVS7+1G>A 7 g.IVS7+3_6 del4bp * novel mutations (HGMD Factor 7 Database, 2009 /http://www.hgmd.org) Disclosures: No relevant conflicts of interest to declare.
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Jarczewska, Marta, Wiktor Bojarski, Aleksandra Majewska, Magdalena Mieczkowska, Marcin Drozd, Robert Ziolkowski, and Elżbieta Malinowska. "Application of Single-Stranded DNA and PNA Probes for Electrochemical Detection of miRNA 141." ECS Meeting Abstracts MA2022-01, no. 53 (July 7, 2022): 2239. http://dx.doi.org/10.1149/ma2022-01532239mtgabs.
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miRNA are known as short RNA molecules that usually consist of 18 – 25 nucleotides and are considered as posttranscriptional regulators of gene expression occurring in plants and animals [1]. Over 60% of all genes which encode proteins are controlled by miRNA [2]. miRNA is engaged in various processes including differentiation, proliferation and apoptosis as well as inflammation. Hence, they might be considered as potential biomarkers of diseases such as cancer, neurodegenerative and cardiovascular [3]. A huge challenge is the actual detection of miRNA because of their short length, low concentration and matrix interferences. The miRNA analysis can be performed with the following techniques such as real-time PCR, northern blotting and microarray [4-6]. However, the above mentioned techniques are rather sophisticated and are costly. An alternative could be the application of electrochemical techniques which are characterized with low detection limits, possibility of miniaturization and high sensitivity. In such a case miRNA could be detected using biosensors containing receptor layers formed of single-stranded DNA or PNA. Herein, we present the studies on the development of ssDNA/PNA – based receptor layers for the electrochemical analysis of miRNA 141, which is a biomarker of pancreatic cancer. Various receptor layers were tested including unlabelled ssDNA, methylene blue-labelled DNA as well as PNA-based. The formation of ssDNA/PNA receptor layer along with its binding to miRNA was confirmed using QCM and SPR techniques. The electrochemical studies revealed that it was not possible to obtain low detection limits for miRNA when MB-labelled ssDNA or PNA molecules were applied. On the contrary, detection limit of 10-4 nM was reached with the application of unlabelled ssDNA molecules. The further analysis showed the possibility of detection of point mutation in ssDNA or miRNA sequence as well as miRNA detection in spiked serum sample. Bibliography: [1] D. P. Bartel, Cell 116 (2004) 281–297 [2] A. Krek, D. Grun, M. N. Poy, R. Wolf, L. Rosenberg, E. J. Epstein, P. MacMenamin, I. da Piedade, K. C. Gunsalus, M. Stoffel, N. Rajewsky, N. Nat. Genet. 37 (2005) 495−500. [3] H. Hwang, J. T. Mendell, Br. J. Cancer 94 (2006) 776–780. [4] C. Chen, D. A. Ridzon, A. J. Broomer, Z. Zhou, D. H. Lee, J. T. Nguyen, M. Barbisin, N. L. Xu, V. R. Mahuvakar, M. R. Andersen, K. Q. Lao, K. J. Livak, K. J.Guegler, Nucleic Acids Res. 33 (2005) e179 [5] A. Valoczi, C. Hornyik, N. Varga, J. Burgyan, S. Kauppinen, Z. Havelda, Nucleic Acids Res. 32 (2004) e175 [6] A. M. Krichevsky, K. S. King, C. P. Donahue, K. Khrapko, K. S.Kosik, RNA 9 (2003) 1274−1281.
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Nechaev, Igor V., and Alexander V. Vvedenskii. "Квантово-химическое моделирование взаимодействия в системе MeN(H2O)M (Me = Cu, AgG, Au; N = 1-3; M = 1, 2)." Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 21, no. 1 (March 6, 2019): 105–15. http://dx.doi.org/10.17308/kcmf.2019.21/722.
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Моделирование реакции малых кластеров IB металлов с молекулами воды проведено в рамках теории функционала плотности. Рассчитана структура, колебательные частоты, зарядовое распределение и другие характеристики изомеров Men(H2O)m (Me = Cu, Ag, Au; n = 1-3; m = 1, 2). Показано, что частицы Cu2 и Cu3 термодинамически способны разлагать воду на водород и гидроксил при стандартных условиях, другие рассмотренные кластеры IB металлов подобной активностью не обладают.
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Kovalenko, Liliya Yu, and Vladimir A. Burmistrov. "Диэлектрическая релаксация и протонная проводимость полисурьмяной кислоты, допированной ионами ванадия." Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 21, no. 2 (June 14, 2019): 204–14. http://dx.doi.org/10.17308/kcmf.2019.21/758.
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Методом импедансной спектроскопии исследованы протонпроводящие свойства полисурьмяной кислоты (ПСК), допированной ионами ванадия. Для твердых растворов состава H2Sb2–xVxO6·nH2O, кристаллизующихся в структурном типе пирохлора (пр. гр. симм. Fd3m), показано, что увеличение количества ванадия в образце приводит к росту удельной протонной проводимости, которая для крайнего твердого раствора замещения H2Sb1.52V0.48O6·nH2O составляет 66 мСм/м. Из анализа данных диэлектрической спектроскопии при температурах 218–298 К определена энергия активации проводимости, которая составила 30±2 КДж/моль. Предложен механизм протонного транспорта, согласно которому в допированных ионами ванадия ПСК проводимость осуществляется посистеме водородных связей, образованных молекулами воды, расположенными в гексагональных каналах структуры типа пирохлора, и анионами кислорода октаэдра, формирующего каркас структуры
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Kłosowski, Karol. "Rozporządzenie 2021/782 – nowe prawa i obowiązki pasażerów oraz przedsiębiorstw kolejowych." internetowy Kwartalnik Antymonopolowy i Regulacyjny 6, no. 11 (December 2022): 52–60. http://dx.doi.org/10.7172/2299-5749.ikar.6.11.5.
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Z dniem 7 czerwca 2023 r. wejdą w życie przepisy przekształconej wersji rozporządzenia 1371/2007 dotyczącego praw i obowiązków pasażerów w ruchu kolejowym. Pierwsza nowelizacja tego podstawowego aktu prawnego w codziennej praktyce pasażerskich przewoźników kolejowych, zarządców infrastruktury, sprzedawców biletów oraz Prezesa UTK wprowadza istotne zmiany w wielu obszarach. Modyfikacji poddane zostały zasady odpowiedzialności przedsiębiorstw kolejowych w przypadku opóźnienia, odwołania lub utraty połączenia. Wprowadzono nowe zasady sprzedaży i odpowiedzialności przedsiębiorstw kolejowych podczas podróży objętych wspólnymi biletami. Wzmocniono uprawnienia osób z niepełnosprawnością oraz o ograniczonej możliwości poruszania się. W istotny sposób zmodyfikowano także zasady dotyczące możliwości przyznawania przez państwa członkowskie terminowych i bezterminowych zwolnień ze stosowania wybranych przepisów rozporządzenia 2021/782. W artykule omówiono najważniejsze zmiany we wskazanych wyżej obszarach.
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Ueda, Takashi, Shinya Ugawa, Yusuke Ishida, Aki Hondoh, and Shoichi Shimada. "Development of Generic Calcium Imaging Assay for Monitoring Gi-Coupled Receptors and G-Protein Interaction." Journal of Biomolecular Screening 14, no. 7 (June 18, 2009): 781–88. http://dx.doi.org/10.1177/1087057109335258.
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G-protein-coupled receptors (GPCRs) are important therapeutic targets for many areas of drug research and development. Although chimeric Gα16 proteins are valuable tools for detecting the activation of Gαi/o-coupled receptors, the details of the activation process remain unclear. The authors introduce a series of chimeras that combine both Gα16 and Gα i/o (Gα16/o, Gα16/i2, and Gα 16/i3) into a well-established transient expression system to examine the ability of these chimeras to interact with D2 long-form (D 2L) dopamine and 5-HT1A serotonin receptors. The pEC 50 data obtained for known agonists were similar to results from previous studies that used other cell-based assays, thus indicating sufficient sensitivity for the assay. Moreover, quinpirole exhibited similar intrinsic activity to dopamine at the D2L receptor, whereas S-(—)-3-PPP displayed partial activity of dopamine and quinpirole in the presence of the Gα16/o chimera. The potency of dopamine for D2L receptors was similar among Gα16/o, Gα16/i2, and Gα 16/i3. In contrast, the 5-HT1A receptor exhibited a significantly preferential coupling for Gα16/i3 compared with Gα 16/i2 when serotonin was used as a ligand. This finding was in close agreement with the results of previous reports. The present system could therefore be used as a rapid functional assay for high-throughput screening and deorphanization. ( Journal of Biomolecular Screening 2009:781-788)
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Agustina, Titien, Wida Gerhana, and Sulaiman ,. "The Effect of Locus of Control, Learning, and Adversity Quotient towards Micro Business Success (Study on Entrepreneurship under Foster Group of the Banjarmasin Regional Government)." Journal of Wetlands Environmental Management 8, no. 1 (February 18, 2020): 21. http://dx.doi.org/10.20527/jwem.v8i1.215.
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AlAli, Musaed, Yaser AlKulaib, Ahmad Bash, Hamed AlDhuaina, Ibraheem AlAskar, and Nabi AlDuwaila. "DIVIDEND POLICY EFFECT ON SHARE PRICES: A COMPARISON STUDY BETWEEN ISLAMIC AND CONVENTIONAL BANKS IN KUWAIT." International Journal of Professional Business Review 9, no. 5 (May 15, 2024): e04608. http://dx.doi.org/10.26668/businessreview/2024.v9i5.4608.
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Ahmad, A., & Hassan, M. (2007). Regulation and performance of Islamic banking in Bangladesh. Thunderbird International Business Review, 492, 251-277. Ahmed, F., Rafay, A., & Ahmed, A. (2018). Dividend Payout Policy of Conventional Banking and Islamic Banking in Pakistan. Al-Iqtishad: Jurnal Ilmu Ekonomi Syariah (Journal of Islamic Economics), 10(1), 135–152. doi: http//dx.doi.org/10.15408/aiq.v10i1.6103 Alasfour, F., Jaara, B., & Abusaleem, K. (2024). Dividend Payout Policy of the Islamic and Conventional Banks in the Gulf Cooperation Council (GCC) Countries. Migration Letters, 21(4), 908-925. Al-Amin, A. (2009). Dividend distribution and its impact on public share prices of shares, the case of the Sudane French Bank. Unpublished Master Thesis, University of Sudan and Technology, Sudan. Al-Ammar. Baker, H., & Weigand, R. (2015). Corporate dividend policy revisited. Managerial Finance, 41(2), 126-144. Bhattacharya, S. (1979). Imperfect Information, Dividend Policy, and 'The Bird In The Hand. Fallacy”. Bell Journal of Economics, 10(1), 259-270 Black, F. (1976). The dividend puzzle. Journal of portfolio management, 2(2), 5-8. Brealey, R. A. & Myers, S. C. (2003). Principles of corporate finance (7th ed.). New York: McGraw Hill. Chang, R., & Rhee, S. (1990). The impact of personal taxes on corporate dividend policy and capital structure decisions. Financial Management, 19(2), 21-31. Dhaliwal, D. S., Erickson, M., & Trezevant, R. (1999). A test of the theory of tax Clienteles for dividend policies. National Tax Journal, 52, 179-194. Donald, K. (2011). International accounting IFRS. John Wiley & Son. 783-784. Doumpos, M., Hasan, I., & Pasiouras, F. (2017). Bank overall financial strength: Islamic versus conventional banks. Economic Modelling, 64, 513-523. Elmagrhi, M., Ntim, C., Crossley, R., Malagila, J., Fosu, S., & Vu, T. (2017). Corporate governance and dividend pay-out policy in UK listed SMEs: The effects of corporate board characteristics. International Journal of Accounting & Information Management, 25(4), 459-483. Eng, S.H., Yahya, M. H., & Hadi, A. R. (2013). The dividend payout policy–a comparison on Malaysian Islamic and conventional financial institutions. Journal of WEI Business and Economics, 2(2), 12-20. Fink, C., & Theissen, E. (2014). Dividend taxation and DAX futures prices (No. 14-08). CFR Working Paper. Hafeez, A. & Attiya, Y. (2009). The Determinants Of Dividend Policy In Pakistan. International Research Journal of Finance Economics, 25, 148-171. Hafsi, R. (2016). Study and analysis of the effect of the dividend policy on the performance of shares of listed companies in the financial market, the case of the Dubai Financial Market for the period 2011-2014, University of Qasdah Murbah and Oqlala. Algerian Journal of Accounting and Financial Studies, 15(2), 39-49. Huda, F., & T. Farah. (2011). Determinants of Dividend Decision: A Focus on Banking Sector in Bangladesh. International Research Journal of Finance and Economics, 77, 33-46. Jaara, O., Jaara, O., Shamieh, J., & Fendi, U. (2017). Liquidity risk exposure in Islamic and Conventional banks. International Journal of Economics and Financial Issues, 7(6), 16-26. Mashkour, S., & Sadiq, Z. (2018). The relationship between the dividend policy and the market value of the stock and its impact on determining the value of the company. Applied research in a sample of banks registered in the Iraqi market for securities. Journal of the Kufa Studies Center, 50, 221-248. Miletkov, M., Moskalev, S., & Wintoki, M. B. (2015). Corporate boards and acquirer returns: international evidence. Managerial Finance, 41(3), 244-266. Nissim, D. & Ziv, A. (2001). Dividend changes and future profitability. The Journal of Finance, 56(6), 2111-2133. Pal, K., & Goyal, P. (2007). Leading Determinants of Dividend Policy: A Case Study of the Indian Banking Industry. Decision (0304-0941), 34(2), 87-98. Petit, R. (1977). Taxes, transactions costs and the Clientele effect of dividends. Journal of Financial Economics, 5, 419-436. Pruitt, S., & Gitman, L. (1991). The interactions between the investment, financing, and dividend decisions of major US firms. Financial Review, 26(33), 409-430. Rafique, M. (2012). Factors affecting dividend payout: Evidence from listed non-financial firms of Karachi stock exchange. Business Management Dynamics, 1(11), 76-92.
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Шукюрова, Елена Борисовна, and Н. С. Марзанов. "Мониторинг аллелофонда EAB-локуса групп крови в процессе селекции крупного рогатого скота голштинской породы в условиях Сахалинской области." Аграрная Россия, no. 12 (December 17, 2021): 26–30. http://dx.doi.org/10.30906/1999-5636-2021-12-26-30.
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В селекции крупного рогатого скота (КРС) большое значение имеет изучение концентрации аллелей групп крови и динамики частоты встречаемости для выявления изменений в генетической структуре, происходящих в процессе селекции, как породы в целом, так и отдельного стада. Установлены изменения генетической ситуации в стаде КРС голштинской породы в условиях Сахалинской области. Генетическую ситуацию контролировали с помощью EAB-локуса групп крови у 782 животных, рожденных в 1999 – 2018 гг. Анализ динамики аллелофонда во времени показал сокращение общего числа аллелей, участвующих в формировании генотипов EAB-локуса, с 42 (потомки 1999 – 2000 гг. рождения) до 21 – 23 (потомки 2015 – 2018 гг. рождения). Произошло изменение уровня гомозиготности в сторону его увеличения с 8,4 (потомки 1999 – 2000 гг. рождения) до 18,2 (потомки 2017 – 2018 гг. рождения), и, как следствие этого, наблюдалось уменьшение числа эффективных аллелей. Использование большого числа быков, носителей аллели G2Y2E2’Q’, привело в хозяйстве к увеличению рождения потомков (2017 – 2018 гг.), носителей данной аллели, в 1,7 раза. У потомков, рожденных с 2003 по 2010 г., элиминировали аллели Q, B2B’’, B2G2KI1O1D’O’Q’, O1Y2, I’, I2I’, O1Y2D’G’Q’, G3O1T1A2’E3’K’, I1O1Y2, QQ’, Y2Q’ и др. За весь период исследования генофонд восполнился только 25 аллелями, что привело к снижению генетического разнообразия в стаде.
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Schouls, Leo, Corrie Schot, Richarda M. de Voer, Fiona van der Klis, Mirjam Knol, Irina Tcherniaeva, and Guy Berbers. "Lagging Immune Response to Haemophilus influenzae Serotype b (Hib) Conjugate Vaccine after the Primary Vaccination with Hib of Infants in The Netherlands." Vaccines 8, no. 3 (June 30, 2020): 347. http://dx.doi.org/10.3390/vaccines8030347.
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In 1993, a Haemophilus influenzae serotype b (Hib) conjugate vaccine was introduced in the Dutch national immunization program, resulting in a sharp decrease in invasive Hib disease. We used a population-based set of serum samples collected in The Netherlands in 2006–2007 (Pienter-II, 5696 sera) to assess the concentration of antibodies to the capsular polysaccharide of Hib, and compared the results with those obtained from a similar set collected in 1995–1996 (Pienter-I, 7837 sera). Post-primary vaccination serum samples from children aged 6–11 months from the Pienter-II study contained approximately 4-fold lower anti-Hib antibody concentrations than samples from children from the Pienter-I study. No such difference was found in post-booster samples from children older than 11 months of age. In Pienter-II, the proportion of children aged 6–11 months with anti-Hib antibody concentrations below the putative protective concentration of 0.15 µg/mL was 30%, which is significantly higher than in the Pienter-I study (12%). Fewer children in the Pienter-II group developed antibodies able to kill Hib in a serum bactericidal assay compared to the Pienter-I children. The cause of the lagged response in Pienter-II children remain uncertain, but lack of natural boosting, interference by the acellular pertussis vaccine, combining vaccines and acceleration of the schedule may have contributed.
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Price, Richard M. "Giuseppe Alberigo (ed.), Conciliorum Oecumenicorum Generaliumque Decreta, Editio Critica. I: The Oecumenical Councils from Nicaea I to Nicaea II (325-787), Turnhout: Brepols Publishers 2006. 371 pp." Annuarium Historiae Conciliorum 38, no. 2 (June 20, 2006): 467–69. http://dx.doi.org/10.30965/25890433-03802010.
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Kostryukov, Victor F., Irina Y. Mittova, Boris V. Sladkopevtsev, Anna S. Parshina, and Dar’ya S. Balasheva. "Роль BiPO4, вводимого через газовую фазу, в процессе создания тонких пленок на поверхности InP." Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 21, no. 2 (June 14, 2019): 215–24. http://dx.doi.org/10.17308/kcmf.2019.21/759.
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Исследованием термооксидирования фосфида индия под воздействием фосфата висмута, вводимого через газовую фазу, установлено ускоряющее воздействие фосфата висмута на процесс формирования пленок. Величина ускорения составляет от 1.5 до 2 раз, и максимальный прирост пленки достигается в первые 10 мин оксидирования. Определяющим процессом является образование фосфата индия за счет вторичного взаимодействия оксидных форм компонентов подложки, лимитируемое диффузией оксидов в твердой фазе. Методами инфракрасной спектроскопии, локального рентгеноспектрального микроанализа и рентгенофазового анализа установлен состав пленок на поверхности InP, основными компонентами которого являются различные фосфаты индия
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Iwanaga, Masako, Yoshito Koga, Midori Soda, Naoko Inokuchi, Daisuke Sasaki, Hiroo Hasegawa, Katsunori Yanagihara, Kazunari Yamaguchi, Shimeru Kamihira, and Yasuaki Yamada. "Trends in Human T-Cell Leukemia Virus Type-1 (HTLV-1) Prevalence and the Incidence of Adult T-Cell Leukemia/Lymphoma (ATL) in Nagasaki, Japan: A Hospital-Based and Population-Based Study." Blood 114, no. 22 (November 20, 2009): 1920. http://dx.doi.org/10.1182/blood.v114.22.1920.1920.
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Abstract Abstract 1920 Poster Board I-943 Introduction: The prevalence of HTLV-1 is mostly evaluated by the age-specific seroprevalence in blood donors, and the results have been conventionally used to estimate the age-specific incidence of ATL in Japan. However, the results may be underestimated due to an age limit (16-69 yr) for donation, a healthy donor effect, and a birth cohort effect. Data concerning the birth-year specific incidence of ATL among HTLV-1 carriers other than blood donors are scarce. Methods: The study evaluated data of the anti-HTLV-1 antibody testing of 10,261 patients (males: 5,523, females: 4,737) who visited the Nagasaki University Hospital during 2000-2007 and data of 360 ATL cases (males: 188, females: 172) who were diagnosed in Nagasaki City (an endemic area in Japan) in a population-based Nagasaki Prefectural Cancer Registry (NPCR). To estimate birth-year specific incidence rates of ATL in population-based HTLV-1 carriers, we used the 2006 census population for Nagasaki City by applying the hospital-based seroprevalence data. Results: Of 10,261 patients, 1,392 (males: 653, females: 739) were HTLV-1 antibody positive. The overall HTLV-1 seroprevalence was 13.57% (95%CI: 12.90-14.23%). The seroprevalence was significantly higher in females than in males (15.60% vs. 11.82%, P<0.0001). The birth-year specific seroprevalence was 18.69% (before 1926), 17.83% (1927-1936), 15.91% (1937-1946), 13.80% (1947-1956), 9.19% (1957-1966), 4.07% (1967-1976), 2.07% (1977-1986), and 0% (after 1987) (a significantly declining trend: P <0.0001). The estimated annual number of HTLV-1 carriers by birth-year in Nagasaki city was 5257, 8093, 8151, 8083, 4434, 2180, 785, and 0, respectively. Finally, we estimated the annual incidence rate of ATLL per 100,000 HTLV-1 carriers by birth-year; 171 (before 1926), 86 (1927-1936), 41 (1937-1946), 32 (1947-1956), 11 (1957-1966), and 0 (after 1967). The crude lifetime risk of developing ATLL in HTLV-1 carriers was estimated to be 7.29% for males and 3.78% for females. Conclusions: The birth-year specific HTLV-1 seroprevalnces in the present study were approximately 50% higher than those previously reported in blood donors1 (for example: 6.22% in those born before 1950). Although it is possible that our results are over-estimated2, the present study suggests that there is still a large pool of elderly HTLV-1 carriers in this endemic area. Further studies are needed to investigate the mechanism of the development of ATL among HTLV-1 carriers for preventing the development. Reference: 1) Iwanaga M et al. Int J Hematol, 2009. 2) Arisawa K et al. Int J Cancer, 2000. Disclosures: No relevant conflicts of interest to declare.
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Hung, Tran Trong, Tran Anh Tu, Dang Thuong Huyen, and Marc Desmet. "Presence of trace elements in sediment of Can Gio mangrove forest, Ho Chi Minh city, Vietnam." VIETNAM JOURNAL OF EARTH SCIENCES 41, no. 1 (January 8, 2019): 21–35. http://dx.doi.org/10.15625/0866-7187/41/1/13543.
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Can Gio mangrove forest (CGM) is located downstream of Ho Chi Minh City (HCMC), situated between an estuarine system of Dong Nai - Sai Gon river and a part of Vam Co river. The CGM is the largest restored mangrove forest in Vietnam and the UNESCO’s Mangrove Biosphere Reserve. The CGM has been gradually facing to numeric challenges of global climate change, environmental degradation and socio-economic development for the last decades. To evaluate sediment quality in the CGM, we collected 13 cores to analyze for sediment grain size, organic matter content, and trace element concentration of Cd, Cr, Cu, Ni, Pb, Zn. Results showed that trace element concentrations ranged from uncontaminated (Cd, Cu, and Zn) to very minor contaminated (Cr, Ni, and Pb). The concentrations were gradually influenced by suspended particle size and the mangrove plants.ReferencesAnh M.T., Chi D.H., Vinh N.N., Loan T.T., Triet L.M., Slootenb K.B.-V., Tarradellas J., 2003. Micropollutants in the sediment of Sai Gon – Dong Nai rivers: Situation and ecological risks. Chimia International Journal for Chemistry, 57, 09(0009–4293), 537–541.Baruddin N.A., Shazili N.A., Pradit S., 2017. Sequential extraction analysis of heavy metals in relation to bioaccumulation in mangroves, Rhizophora mucronata from Kelantan delta, Malaysia. AACL Bioflux, 10(2), 172-181. Retrieved from www.bioflux.com/aacl.Bravard J.-P., Goichot M., Tronchere H., 2014. An assessment of sediment transport processes in the lower Mekong river based on deposit grain size, the CM technique and flow energy data. Geomorphology, 207, 174-189.Cang L.T., Thanh N.C. 2008. Importing and exporting sediment to and from mangrove forest at Dong Trang estuary, Can Gio district, Ho Chi Minh city. Science & Technology Development, 11(04), 12-18.Carignan J., Hild P., Mevelle G., Morel J., Yeghicheyan D., 2001. 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Mangroves of Vietnam: Chapter VI Human impacts on the mangrove ecosystem. Bangkok 10501: IUCN - The International Union for Conservation of Nature, ISBN: 2-8317-0166-x.Hubner R., Astin K.B., Herbert R.J., 2009. Comparison of sediment quality guidelines (SQGs) for the assessment of metal contamination in marine and estuarine environments. Journal of Environmental Monitoring, 11, 713–722.IAEA, 2003. Collection and preparation of bottom sediment samples for analysis of radionuclides and trace elements. Vienna, Austria: International Atomic Energy Agency, IAEA-TECDOC-1360, ISBN 92–0–109003–X.Jingchun L., Chongling Y., Ruifeng Z., Haoliang L., Guangqiu Q., 2008. Speciation changes of Cd in mangrove (Kandelia Candel L.) rhizosphere sediments. Bull Environ Contam Toxicol, 231-236. Doi:10.1007/s00128-007-9351-z.Kalaivanan R., Jayaprakash M., Nethaji S., Arya V., Giridharan L., 2017. Geochemistry of Core Sediments from Tropical Mangrove Region of Tamil Nadu: Implications on Trace Metals. 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Boonchari, D., and K. Saengsura. "IDEMPOTENT AND REGULAR COHYPERSUBSTITUTIONS OF TYPE τ = (3)." Asian-European Journal of Mathematics 06, no. 02 (June 2013): 1350030. http://dx.doi.org/10.1142/s1793557113500307.
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A mapping σ which assigns to every n-ary cooperation symbol fi an ni-ary coterm of type τ = (ni)i∈I is said to be a cohypersubstitution of type τ. The concepts of cohypersubstitutions were introduced in [Cohyperidentities and M-solid classes of coalgebras, Discrete Math.309(4) (2009) 772–783]. Every cohypersubstitution σ of type τ induces a mapping [Formula: see text] on the set of all coterms of type τ. The set of all cohypersubstitutions of type τ under the binary operation [Formula: see text] which is defined by [Formula: see text] for all σ1, σ2 ∈ Cohyp(τ) forms a monoid which is called the monoid of cohypersubstitution of type τ. In this research, we characterize all idempotent and regular elements of Cohyp(τ) where τ = (3).
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Awal, Jumaidil, and Muhamad Abdulkadir Martoprawiro. "Video Demonstrations of a Benzene Derivative Reaction from Its Optimized Intermediate Structure." J-PEK (Jurnal Pembelajaran Kimia) 8, no. 1 (May 7, 2023): 20. http://dx.doi.org/10.17977/um026v8i12023p20-26.
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A number of researchers have performed studies on the application of chemical reaction visualization by means of computational chemistry techniques for the purpose of teaching and learning chemistry at secondary and higher education levels. However, on practical grounds, the presented approach thus far was generally unattainable for teachers due to the time-consuming process of finding the transition states. This research offers a less time-consuming computational chemistry technique for producing organic reaction-modelling videos upon which the students may sufficiently build their understanding of fundamental concepts of chemical reactions. The technique being proposed here consists of (1) intermediate structure modelling, (2) reactant-wise and product-wise optimizations of the intermediate structures without the search for transition states, and (3) visualizations of the optimized results. The application of this technique has managed to produce a video demonstration of an organic reaction of benzene derivatives that may serve as modelling videos in chemistry lessons at secondary education or undergraduate degree levels.REFERENCESBode, B. M., & Gordon, M. S. (1998). Macmolplt: A graphical user interface for GAMESS. Journal of Molecular Graphics and Modelling, 16(3), 133–138. https://doi.org/10.1016/S1093-3263(99)00002-9Carey, F. A. (2000). Organic chemistry (4th ed). McGraw-Hill.Cohlberg, J. A. (2021). Exploring Proteins and Nucleic Acids with Jmol. W. H. Freeman and Company. https://home.csulb.edu/~cohlberg/Jmolmanual.pdfCramer, C. J. (2004). Essentials of computational chemistry: Theories and models (2nd ed). Wiley.Hanwell, M. D., Curtis, D. E., Lonie, D. C., Vandermeersch, T., Zurek, E., & Hutchison, G. R. (2012). Avogadro: An advanced semantic chemical editor, visualization, and analysis platform. 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African Journal of Chemical Education, 4(3), 22–33.Ikuo, A., Saito, K., Yoshinaga, Y., & Ogawa, H. (2013). Development of Teaching Material in Tablet PC for Experiment of Nitration of Benzene Based on Computer Graphics by Quantum Chemical Calculation. Work-in-Progress Poster of the International Conference on Computers in Education: ICCE 2013, 21–23.Koreeda, M. (2011). Chem 216 S11 Notes [Lab work notes]. http://websites.umich.edu/~chem216/216% 20S11-Expt%201.pdfLevine, I. N. (2009). Physical chemistry (6th ed). McGraw-Hill.Lewars, E. G. (2016). Computational Chemistry: Introduction to the Theory and Applications of Molecular and Quantum Mechanics. Springer.Mendera, I. G. (2020). Kimia: Benzena dan Turunannya. Direktorat SMA Ditjen PAUD, Dikdas, dan Dikmen Kemendikbud.Neese, F., Wennmohs, F., Becker, U., & Riplinger, C. (2020). The ORCA quantum chemistry program package. The Journal of Chemical Physics, 152(22), 224108. https://doi.org/10.1063/5.0004608Nursanti, Y. I. (2020). Modul Tema 15: Berpadu dan Bersenyawa. Direktorat Dikmas dan Diksus Ditjen PAUD, Dikdas, dan Dikmen Kemendikbud.Omer, R., Koparir, P., Ahmed, L., & Koparir, M. (2020). Computational determination the reactivity of salbutamol and propranolol drugs. Turkish Computational and Theoretical Chemistry, 4(2), 67–75. https://doi.org/10.33435/tcandtc.768758Polik, W. F., & Schmidt, J. R. (2022). WebMO: Web‐Based Computational Chemistry Calculations in Education and Research. WIREs Computational Molecular Science, 12(1), e1554.Putri, P. (2016). Tata Nama Senyawa dan Perhitungan Kimia—Karakteristik Peserta Didik. P4TK Bisnis dan Pariwisata Ditjen GTK Kemendikbud.Rahayu, I. (2009). Praktis Belajar Kimia untuk Kelas XII SMA/MA Program IPA. Pusat Perbukuan Depdiknas.S. Fernandes, H., Ramos, M. J., & M. F. S. A. Cerqueira, N. (2018). molUP: A VMD plugin to handle QM and ONIOM calculations using the gaussian software: A VMD Plugin to Handle QM and ONIOM Calculations. Journal of Computational Chemistry, 39(19), 1344–1353. https://doi.org/10.1002/jcc.25189Schaftenaar, G., Vlieg, E., & Vriend, G. (2017). Molden 2.0: Quantum chemistry meets proteins. Journal of Computer-Aided Molecular Design, 31(9), 789–800. https://doi.org/10.1007/s10822-017-0042-5Wardiyah. (2016). Kimia Organik. BPPSDMK Pusdik SDM Kesehatan Kemenkes.
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Baujat, Bertrand, Anne Catherine Baglin, Frederic Chabolle, Valerie Costes Martineau, Francois Janot, Sylvie Testelin, Juliette Thariat, and Emile Reyt. "A French national network for rare head and neck cancers (REFCOR)." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): e16013-e16013. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e16013.
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e16013 Background: Squamous cell carcinomas of upper aerodigestive tract and endemic undifferenciated nasopharyngeal carcinomas are the most frequent head and neck (H&N) cancers. Apart from these two entities, malignant H&N tumors are uncommon due to their location and/or their histological type. They account for 10% of H&N cancers (around 2,000 new cases/year in France). The rarity of these cancers limits the progress in all aspects. Treatments are based on low level scientific proofs. In most histological types, chemotherapy is uneffective. Prognosis is usually threatening. It was necessary to federate medical centers at a national level to enhance epidemiological knowledge, quality of patient management and to promote research projects. Methods: Structuration of the network included: 2008-2009: 4 working groups to edit recommandations of good practice in diagnosis and treatment of sinus cancers, salivary glands cancers, ear cancers, upper aerodigestive tract non squamous cell carcinoma cancers; 2009: A national database including sociodemographical, clinical, epidemiological, histological and follow-up data; 2009: Organization of biorepositories; 2010: A national group of expert pathologists for diagnosis advice (telepathology); 2011: Specialized multidisciplinary clinics at regional and national levels. Results: To date, 783 patients were included in the database by 29 centers. Tumor sites were sinus/nasal fossa (53%), Salivary glands (28%), Upper aerodigestive tract (18%), ear (1%). Stage at diagnosis repartition was 15% stage I, 24% stage II, 17% stage III, 44% stage IV. Main histological types are adenocarcinoma (17%), Adenoid Cystic carcinoma (9%), mucoepidermoid carcinoma (5%), muquous melanoma (5%). 337 biospecimens are referenced. Conclusions: The majority of french centers involved in H&N cancers treatment contribute to this project. This network is a unique tool for improving the knowledge of rare H&N tumors. Ongoing epidemiological studies will shortly be published. Translational studies based on biospecimens will follow. Collaboration with other networks such as the Salivary Gland Tumors Biorepository could be useful in the next future. Funding source: French National Institute of Cancer (INCa).
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ANDREWS, MOLLY. "Ageful and proud." Ageing and Society 20, no. 6 (November 2000): 791–95. http://dx.doi.org/10.1017/s0144686x01007966.
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There is something splendid about the word ageful – a word which I had not encountered before reading Bytheway (2000). Ironically, Bytheway does not share my affection for his invention; rather, for him it seems to have negative connotations, reflected in his comment: ‘as gerontologists we are vulnerable to seeing ourselves and those we study entirely in terms of age: as ageing rather than living individuals: ageful rather than ageless’ (2000: 785–6). But why this juxtaposition between ageing and living? Surely there is an interconnectedness between the two. We are ageing from the moment we are born; the longer we live, the more full of age we become.
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Boff, Eva Teresinha de Oliveira, Aline Bernard, and Graça Simões de Carvalho. "Promoção da alimentação saudável no contexto do livro didático e do fazer docente (Healthy food promotion in the context of textbooks and the teaching action)." Revista Eletrônica de Educação 15 (November 30, 2021): e4910061. http://dx.doi.org/10.14244/198271994910.
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e4910061The object of this study is to identify the contents about Food and Nutrition Education (FNE) in textbooks of sixth to ninth grades of Brazilian elementary school and to comprehend the teaching conceptions related to possible links between those concepts and the FNE. The National Program of School Feeding - NPSF guides the FNE actions towards different pieces of knowledge considering culture, history, geography (BRASIL, 2020). FNE can be a pedagogical resource of contextualization to many knowledge areas. It is a qualitative research, which results were obtained through discursive textual analysis of twenty didactic books, semi-structured interviews, and discussions between the nutritionist, the teachers and the students that took part in the study. Analysis showed that didactic books present few contents of FNE, generally referring to biomedical aspects. Teachers recognized the importance of FNE as a constitutive element of the curriculum, but they found it difficult to link such a theme with disciplinary concepts. The study reveals the importance of collective work of both health and education professionals since school age is propitious to create healthy habits and lifestyles.Resumo O objetivo deste estudo foi identificar os conteúdos sobre Educação Alimentar e Nutricional (EAN) presentes em livros didáticos do 6º ao 9º anos do Ensino Fundamental brasileiro e compreender as concepções docentes relacionadas às possíveis articulações entre os conceitos específicos disciplinares e EAN. O Programa Nacional de Alimentação Escolar (PNAE) orienta que as ações de EAN se articulem com os diferentes saberes que consideram a cultura, a história e a geografia (BRASIL, 2020). A EAN pode ser um recurso pedagógico de contextualização das diferentes áreas do conhecimento. Trata-se de uma pesquisa qualitativa, cujos resultados foram obtidos por meio da análise textual discursiva de 20 livros didáticos, de entrevistas semiestruturadas e discussões entre nutricionista, professores e alunos participantes do estudo. A análise mostra que os livros didáticos apresentam poucos conteúdos de EAN, normalmente centrados em aspectos biomédicos. As professoras reconhecem a importância da EAN como constitutiva do currículo escolar, mas têm dificuldades em articular a temática com os conceitos disciplinares. O estudo mostra a importância da realização de trabalho coletivo entre profissionais da saúde, no caso EAN, e da educação, pois a idade escolar é a mais propícia para a formação de estilo de vida e hábitos alimentares saudáveis.Palavras chave: Educação alimentar, Currículo, Ensino contextualizado.Keywords: Food Education, Curriculum, Contextualized teaching.ReferencesALBUQUERQUE, A. G.; PONTES, C. M. E.; OSÓRIO, M. M. Conhecimento de educadores e nutricionistas sobre educação alimentar e nutricional no ambiente escolar. Rev. Nutr., Junho de 2013, vol.26, no.3, p.291-300.ALMEIDA, D. R. D. S. Pierre Bourdieu: a transformação social no contexto de “A reprodução”. Revista Inter Ação, Goiás, v. 30, n. 1, p. 139-155, 2005. BERNARD, A.; BOFF, E. T.O.; CARVALHO, M. G. F. S. Eating habits associated with nutritional deviation in elementary school students. O Mundo da Saúde (Impresso). v.42, p.478 - 498, 2018.BOFF, E. T. O. Processo Interativo: Uma Possibilidade de Produção de um Currículo Integrado e Constituição de um Docente Pesquisador-Autor e Ator - de seu fazer Cotidiano Escolar. Tese de doutorado. Porto Alegre: UFRGS, 2011.BOFF, E. T.O; DEL PINO, J. C. Processo interativo de formação docente: uma perspectiva emancipatória na constituição do currículo escolar. Curitiba: Appris, 2018.BOOG, M. C. F. Educação em nutrição: integrando experiências. Campinas: Komedi, 2014.BOURDIEU, P.; PASSERON, J.C. A reprodução: elementos para uma teoria do sistema de ensino. Rio de Janeiro: Francisco Alves, 2014.BOURDIEU, P. Gostos de classe e estilos de vida. In: ORTIZ, R (org.). Pierre Bourdieu: sociologia. 2. ed. São Paulo: Ática, 1983. p. 82-121. BOURDIEU, P. A distinção: crítica social do julgamento.2. ed. Porto Alegre: Zouk, 2017.BRASIL. Ministério da Educação. Base Nacional Comum Curricular. Brasília, DF: MEC, 2018. Disponível em: http:base-nacionalcomum.mec.gov.br/ima-ges/BNCC_EI_EF _1105 18_ versaofinal_site.pdf. Acesso em: 20 set. 2020.BRASIL. Ministério da Educação. Secretaria de Educação Fundamental. Parâmetros Curriculares Nacionais: ciências naturais. Brasília, DF, 1998.BRASIL. Ministério da Saúde. Secretaria de Políticas de Saúde. Projeto Promoção da Saúde. As Cartas da Promoção da Saúde, 2002. 56 p.BRASIL. Resolução/CD/FNDE nº 38, de 16 de julho de 2009. Dispõe sobre o atendimento da alimentação escolar aos alunos da educação básica no Programa Nacional de Alimentação Escolar – PNAE. Brasília, DF, 2009a. BRASIL. Manual técnico de promoção da saúde e prevenção de riscos e doenças nasaúde suplementar. Agência Nacional de Saúde Suplementar(Brasil). 3. ed. rev. e atual.Rio de Janeiro: ANS, 2009b. 244 p.BRASIL. Lei n° 11.947 de 16 junho 2009c. Dispõe sobre o atendimento da alimentaçãoescolar e do Programa Dinheiro Direto na escola aos alunos da Educação Básica.Disponível em: http://www.planalto.gov.br/ccivil_03/_Ato2007-2010/2009/Lei/L11947.htmAcesso em: 7 jul. 2020.BRASIL. Lei Nº 5.692, DE 11 de agosto de 1971. Brasília, DF, 1971. https://www2.camara.leg.br/legin/fed/lei/1970-1979/lei-5692-11-agosto-1971-357752publicacaooriginal-1-pl.htmlBRASIL. Resolução nº 466/2012. Diretrizes e normas regulamentadoras de pesquisas envolvendo seres humanos. Brasília, DF. 2012a.BRASIL. Ministério da Saúde. Secretaria de Atenção à Saúde. Departamento de AtençãoBásica. Guia alimentar para a população brasileira. Brasília, 2014.BRASIL. Secretaria Nacional de Segurança Alimentar e Nutricional. Ministério do Desenvolvimento Social e Combate à Fome. Marco de Referência de Educação Alimentar e Nutricional para as Políticas Públicas. Brasília, 2012b.BRASIL. Programa Nacional de Alimentação Escolar. Resolução N° 6, de 8 de maio de2020 – PNAE. 2020. Disponível em: http://www.in.gov.br/en/web/dou/-/resolucao-n-6-de-8de-maio-de-2020-256309972.BRASIL. Ministério da Educação. Ministério da Saúde. Institui o Programa Saúde na Escola (PSE) e dá outras providências. Diário Oficial da União, Brasília, 2007.CAMOZZI, A. B. Q. et al. Promoção da alimentação saudável na escola: realidade ou utopia? Cad. Saúde Colet., Rio de Janeiro, v.23, n.1, p. 32-37, 2015.DIEZ-GARCIA, R. W.; CASTRO, I. R. R. A culinária como objeto de estudo e de intervenção no campo da alimentação e nutrição. Ciênc. Saúde Coletiva[on-line], v.16, n.1, p. 91-98, 2011.DORNELLES, A.D.; ANTON, M. C.; PIZZINATO, A. O papel da sociedade e da família na assistência ao sobrepeso e à obesidade infantil: percepção de trabalhadores da saúde em diferentes níveis de atenção. Saúde Soc., v.23, n.4, p. 1.275-1.287, 2014.FIORE, E. G. et al. Abordagem dos temas alimentação e nutrição no material didático do Ensino Fundamental: interface com segurança alimentar e nutricional e parâmetros curriculares nacionais. Saúde Soc., São Paulo, v.21, n.4, p. 1.063-1.074, 2012.MARQUES, R. F. R.; GUTIERREZ, G. L. Contribuições teóricas da obra de Pierre Bourdieu à educação nutricional. In:MENDES, R. T.;VILARTA, R.;GUTIERREZ, G. L. (org.). Qualidade de vida e cultura alimentar. Campinas: Ipês, 2009. p. 97-106.MORAES, R.; GALIAZZI, M. C. Análise textual discursiva. Ijuí: Editora Unijuí, 2020.MOREIRA, A. F. B. O campo do currículo no Brasil: os anos noventa. Currículo sem Fronteiras, v.1, n.1, p.35-49, 2001.PASTORIO, Eduardo. Horta Escolar nas Escolas do Campo de São Gabriel/RS. RELACult – Revista Latino-Americana de Estudos em Cultura e Sociedade, [S. l.], v. 6, maio 2020. ISSN 2525-7870. Disponível em: http://periodicos.claec.org/index.php/relacult/article/view/1675.PIPITONE, M. A. P.et al. A educação nutricional no programa de Ciências para o Ensino Fundamental. Saúde Rev., Piracicaba, v.5, n.9, p. 29-37, 2003.RAMOS, F. P.; SANTOS, L. A. S.; REIS, A. B. C. Educação alimentar e nutricional em escolares: uma revisão de literatura. Cad. Saúde Pública, v.29, n.11, p. 2.147-2.161, 2013.SANTIAGO, L. A. S et al. O que os livros didáticos dizem sobre a temática indígena: o antes e o depois da Lei 11.645/2008. Debates em Educação, v.10, n.21, maio/ago. 2018.SILVA, J. G.; TEIXEIRA, M. L. O.; FERREIRA, M. A. Alimentação na adolescência e as relações com a saúde do adolescente. Texto Contexto Enferm. Florianópolis, v.23, n.4, p. 1.095-1.103, out/dez. 2014.THIESEN, J. S. A interdisciplinaridade como um movimento articulador no processo ensino e aprendizagem. Revista Brasileira de Educação, v.13, n.39, set/dez. 2008.VIGOTSKI, L. S. Pensamento e linguagem.4. ed. São Paulo: Martins Fontes, 2013.
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Wieliczko, Barbara. "Investment in machinery, equipment and means of transport in Polish agriculture, 2009-2012: example of FADN region 785 (Pomorze i Mazury)." Studies in Agricultural Economics 117, no. 1 (April 1, 2015): 43–49. http://dx.doi.org/10.7896/j.1506.
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Bennett, William N., Joseph Yabes, Katrin Mende, Miriam Beckius, Azizur Rahman, and David Tribble. "788. Enterobacter cloacae Infection Characteristics and Outcomes in Military Personnel who Sustained Trauma in Iraq and Afghanistan." Open Forum Infectious Diseases 8, Supplement_1 (November 1, 2021): S490—S491. http://dx.doi.org/10.1093/ofid/ofab466.985.
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Abstract Background Enterobacter cloacae is a Gram-negative rod with chromosomally-induced Amp-C β-lactamase with multidrug-resistant potential. Joint Trauma System guidelines for treating combat wounds include prophylaxis with cefazolin and ertapenem, potent inducers of Amp-C. We evaluated clinical characteristics, antibiotic utilization, and outcomes associated with battlefield-related E. cloacae infections. Methods All initial solitary (those with single isolates) and serial E. cloacae isolates (≥24 hours from initial isolate from any site) were collected from the Trauma Infectious Disease Outcomes Study (6/2009-12/2014). Inclusion required E. cloacae isolation from a clinical infection. Amp-C-inducing β-lactams were classified based on induction potential and lability to the Amp-C β-lactamase as Amp-C induction levels. Results Of 653 E. cloacae isolates, 253 met inclusion criteria – 64 patients had only initial isolates, 54 patients had serial isolates. Patients were largely male (99%), median age 23 years (IQR 21-27), with injury severity score of 34 (IQR 24-45). Initial isolates were wound (70%), respiratory (22%), blood (7%), urine (1%), and other (1%). Patients commonly had blast injuries (89%), required ICU admission (95%), and had a median hospital stay of 57 days (IQR 39-82). Patients with serial isolates showed a trend towards earlier clinical infection (5 vs 8 days, P = 0.07). They were also less likely to receive carbapenems prior to E. cloacae isolation compared to those with only initial isolates (4% vs 38%) and more likely to receive 1st generation cephalosporins (79% vs 58%, P = 0.01). The serial isolate group received more days of 1st generation cephalosporins (median 6 days vs 2.5 days, P = 0.01). Cumulative antimicrobial therapy trended towards significance and was greater with the serial isolates (median 100 days vs 74 days, P = 0.08). There was no difference in number of surgical interventions between those with and without serial isolates (P = 0.54). Overall, 6 patients died. Conclusion E. cloacae infections after battlefield trauma were frequently encountered and associated with exposure to 1st generation cephalosporins. Serial infections did not correlate to worse patient outcomes but displayed a trend towards an overall greater duration of antibiotic use. Disclosures William N. Bennett, V, MD, Abbvie (Shareholder)Amgen (Shareholder)Nabriva (Shareholder)
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Arora, Sukeshi Patel, Norma S. Ketchum, Jonathan Gelfond, Joel Michalek, and Devalingam Mahalingam. "Phase I clinical trials in refractory colorectal cancer (CRC): Do older adult patients benefit?" Journal of Clinical Oncology 36, no. 4_suppl (February 1, 2018): 784. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.784.
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784 Background: Current clinical trial data are largely driven by younger participants, yet half the population diagnosed with CRC are 70+. Upon progression, many CRC patients (pts) with refractory cancer are referred to phase 1 clinical trials; however, tolerability and clinical benefit is unclear in the elderly. Given our robust phase 1 program, we assessed the efficacy and safety of early therapeutics in the elderly CRC pts. Methods: A historical cohort analysis included mCRC pts enrolled amongst 44 phase I trials from 3/2004 - 9/2012. Median Progression free survival (mPFS) and overall survival (mOS) were estimated from Kaplan-Meier curves and groups were statistically compared with the log rank test. The magnitude of association between dichotomous factors and survival was estimated with the hazard ratio (HR). Results: 139 pts, median age 59 (33-81), 70+ 16.5% (n = 23); KRAS mut 39.4 %. ≥3 prior lines of therapy 73.9 %; Prior EGFR-I 75.5% (100% of KRAS wt). Location: Right 20.9 %, Left 61.9 %, Transverse 4.3 %, Unknown 12.9 %. Phase I agents: VEGF I 19.4%, EGFR/Growth Factor I 9.3%. mOS for < 70 (n = 108) vs 70+ (n = 22): 6.5 vs 4.2 months (HR 1.88, p 0.007). mPFS for < 70 (n = 116) vs 70+ (n = 23): 2.0 months vs x 1.5 months (HR 1.73, P 0.03). There was not a statistical difference between < 70 versus 70+ in regards to dose cohort, number of cycles completed, or adverse events. Survival analysis in terms of risk factors in pts 70+ are in the Table below. Conclusions: Elderly CRC pts are underrepresented (16.5%) in phase 1 clinical trials and have worse survivals than non-elderly pts. Elderly CRC pts with liver and hematologic toxicities had a trend toward worse PFS but no OS. Phase I studies should incorporate prospective assessments to identify risk factors of morbidity and mortality in elderly CRC pts. [Table: see text]
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Panteleeva, Viktoria V., Ilya S. Votinov, Igor S. Polkovnikov, and Anatoliy В. Shein. "КИНЕТИКА КАТОДНОГО ВЫДЕЛЕНИЯ ВОДОРОДА НА МОНОСИЛИЦИДЕ МАРГАНЦА В СЕРНОКИСЛОМ ЭЛЕКТРОЛИТЕ." Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 21, no. 3 (September 26, 2019): 432–40. http://dx.doi.org/10.17308/kcmf.2019.21/1153.
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Методами поляризационных и импедансных измерений изучена кинетика реакции выделения водорода на MnSi-электроде в сернокислых растворах с различной концентрацией ионов водорода. Сделано предположение о механизме выделения водорода на силициде. Отмечено влияние тонкой оксидной пленки на кинетику выделения водорода на MnSi при невысоких катодных поляризациях.
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Trisca, Jorge Omar, Anneth Medina Rocha, Jaime Rodríguez Gómez, and Mónica Cely Salazar. "Motivación para el trabajo intelectual, estilos de aprendizaje y estrategias metacognoscitivas en alumnos de educación media." RIEE | Revista Internacional de Estudios en Educación 19, no. 1 (January 28, 2019): 19–34. http://dx.doi.org/10.37354/riee.2019.187.
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El aprendizaje autorregulado, los estilos de aprendizaje y la motivación para el trabajo intelectual tienen gran importancia en la actualidad por su influencia sobre los procesos de aprendizaje. Este estudio, descriptivo y correlacional, procura determinar el grado de relación que existe entre estas variables y su nivel de significación, pues esta información podría ser de gran ayuda en el momento de planear las estrategias de aprendizaje dentro de las aulas. Se administró el Cuestionario Honey-Alonso de Estilos de Aprendizaje (CHAEA) y el Cuestionario de Estrategias de Aprendizaje y Motivación (CEAM) para el trabajo intelectual a una muestra de 110 alumnos de una escuela preparatoria de Mérida, Yucatán, México. Se encontró que la supervisión y la autoevaluación, como estrategias metacognitivas, fueron las mejores valoradas. Por otro lado, la organización de la información resaltando las ideas principales obtuvo una valoración muy pobre. El modelo planteado para analizar la relación entre las estrategias metacognitivas, la motivación y los estilos de aprendizaje alcanzó niveles de ajuste satisfactorios. Se observa una aparente ausencia de relación entre la motivación y los estilos de aprendizaje en coincidencia con resultados de otros estudios consultados. Por otro lado, en la literatura se ha encontrado que estudiantes con ciertos estilos de aprendizaje tienden a tener una preferencia por determinadas estrategias metacognitivas. No obstante, en la presente investigación no se observaron tales correlaciones, lo cual puede atribuirse a que en esta investigación el desarrollo de los diferentes estilos de aprendizaje es muy equilibrado, además de que únicamente la mitad de los encuestados tiende a tener un estilo preferente. En conclusión, los estilos de aprendizaje conforman un constructo que es independiente de la motivación y las estrategias metacognitivas.
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Alarcón Díaz, M. A. (2013). Motivación, estrategias de aprendizaje y metacomprensión lectora: un estudio descriptivo en alumnos universitarios peruanos. Revista Educación y Desarrollo Social, 7(1), 71-78. https://doi.org/10.18359/reds.735
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Sferruzzi-Perri, Amanda N., Julie A. Owens, Prue Standen, Robyn L. Taylor, Jeffrey S. Robinson, and Claire T. Roberts. "Early Pregnancy Maternal Endocrine Insulin-Like Growth Factor I Programs the Placenta for Increased Functional Capacity throughout Gestation." Endocrinology 148, no. 9 (September 1, 2007): 4362–70. http://dx.doi.org/10.1210/en.2007-0411.
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In early pregnancy, the concentrations of IGFs increase in maternal blood. Treatment of pregnant guinea pigs with IGFs in early to midpregnancy enhances placental glucose transport and fetal growth and viability near term. In the current study, we determined whether exogenous IGFs altered placental gene expression, transport, and nutrient partitioning during treatment, which may then persist. Guinea pigs were infused with IGF-I, IGF-II (both 1 mg/kg·d) or vehicle sc from d 20–35 of pregnancy and killed on d 35 (term is 70 d) after administration of [3H]methyl-d-glucose (MG) and [14C]amino-isobutyric acid (AIB). IGF-I increased placental and fetal weights (+15 and +17%, respectively) and MG and AIB uptake by the placenta (+42 and +68%, respectively) and fetus (+59 and +90%, respectively). IGF-I increased placental mRNA expression of the amino acid transporter gene Slc38a2 (+780%) and reduced that of Igf2 (−51%), without altering the glucose transporter Slc2a1 or Vegf and Igf1 genes. There were modest effects of IGF-I treatment on MG and AIB uptake by individual maternal tissues and no effect on plasma glucose, total amino acids, free fatty acids, triglycerides, and cholesterol concentrations. IGF-II treatment of the mother did not alter any maternal, fetal or placental parameter. In conclusion, exogenous IGF-I, but not IGF-II, in early pregnancy increases placental transport of MG and AIB, enhancing midgestational fetal nutrient uptake and growth. This suggests that early pregnancy rises in maternal circulating IGF-I play a major role in regulating placental growth and functional development and thus fetal growth throughout gestation.
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Haering, Stephan. "Conciliorum oecumenicorum generaliumque decreta. Editio critica. I: The Oecumenical Councils. From Nicaea I to Nicaea II (325-787), curantibus G. Alberigo u. a. Turnhout: Brepols 2006, XIV, 371 S. (= Corpus Christianorum)." Archiv für katholisches Kirchenrecht 176, no. 1 (June 24, 2007): 291–93. http://dx.doi.org/10.30965/2589045x-17601029.
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Vandas, M., E. P. Romashets, and S. Watari. "New Force-Free Models of Magnetic Clouds." Highlights of Astronomy 13 (2005): 133. http://dx.doi.org/10.1017/s1539299600015331.
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AbstractMagnetic clouds are thought to be large flux ropes propagating through the heliosphere. Their twisted magnetic fields are mostly modeled by a constant-alpha force-free field in a circular cylindrical flux rope (the Lundquist solution). However, the interplanetary flux ropes are three dimensional objects. In reality they possibly have a curved shape and an oblate cross section. Recently we have found two force-free models of flux ropes which takes into account the mentioned features. These are (i) a constant-alpha force-free configuration in an elliptic flux rope (Vandas & Romashets 2003, A&A, 398, 801), and (ii) a non-constant-alpha force-free field in a toroid with arbitrary aspect ratio (Romashets & Vandas 2003, AIP Conf Ser. 679, 180). Two magnetic cloud observations were analyzed. The magnetic cloud of October 18-19, 1995 has been fitted by Lepping et al. (1997, JGR, 102, 14049) with use of the Lundquist solution. The cloud has a very flat magnetic field magnitude profile. We fitted it by the elliptic solution (i). The magnetic cloud of November 17-18, 1975 has been fitted by Marubashi (1997) with use of a toroidally adjusted Lundquist solution. The cloud has a large magnetic field vector rotation and a large magnetic field magnitude increase over the background level. We fitted it by the toroidal solution (ii). The both fits match the rotation of the magnetic field vector in a comparable quality to the former fits, but the description of the magnetic field magnitude profiles is remarkable better. It is possible to incorporate temporal effects (expansion) of magnetic clouds into the new solutions through a time-dependent alpha parameter as in Shimazu & Vandas (2002, EP&S, 54, 783).
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Noce, Cesar Werneck, and Marise Souto Rebelo. "Avaliação da Relação entre Tamanho do Tumor e Características Sociais em Pacientes com Carcinoma de Células Escamosas Bucal." Revista Brasileira de Cancerologia 54, no. 2 (June 30, 2008): 123–29. http://dx.doi.org/10.32635/2176-9745.rbc.2008v54n2.1739.
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O carcinoma de células escamosas (CEC) acomete principalmente homens com mais de 50 anos, tabagistas e etilistas. Muitos pacientes com CEC em mucosa bucal já apresentam lesões avançadas, reduzindo seu prognóstico. O objetivo deste estudo foi analisar as características sociais dos pacientes com CEC bucal, correlacionando-as com o tamanho do tumor. Foi realizado levantamento dos casos de CEC bucal, a partir das informações cadastradas de 2000 a 2003, no Hospital do Câncer I (HC I) do Instituto Nacional de Câncer (INCA). Foram coletados dados referentes a sexo, idade, grau de escolaridade, tabagismo, etilismo, distância entre o bairro de residência e o local de assistência médica e local anatômico e tamanho do tumor no momento da admissão do paciente no INCA. Foram analisados 1.308 prontuários, sendo 1.029 homens (78,7%) e 279 (21,3%) mulheres. Tumores de tamanhos maiores foram relacionados a um menor grau de escolaridade (p=0,011). Por outro lado, a distância entre o bairro de residência e o local de assistência não se mostrou estatisticamente significante em relação ao tamanho do tumor (p=0,134). O baixo grau de escolaridade conferiu-se como risco para o tamanho do tumor, mas tal relação não foi observada em relação à distância entre o bairro de residência e o local de assistência. Novos estudos são necessários para minimizar as falhas referentes às variáveis sociais selecionadas neste estudo de modo a permitir uma avaliação mais precisa em relação à associação avaliada.
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Pavon-Romero, Gandhi F., Désirée E. Larenas-Linnemann, Karen Eloisa Xochipa Ruiz, Fernando Ramirez-Jimenez, and Luis M. Teran. "Subcutaneous Allergen-Specific Immunotherapy Is Safe in Pediatric Patients with Allergic Rhinitis." International Archives of Allergy and Immunology 182, no. 6 (2021): 553–61. http://dx.doi.org/10.1159/000513158.
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<b><i>Introduction:</i></b> Subcutaneous allergen-specific immunotherapy (SCIT) is one of the main cornerstones in the treatment of allergic rhinitis in pediatric patients. It has demonstrated symptoms and quality of life improvement, but it is not exempt from adverse reactions (ADVrs). Nevertheless, there are a few reports that have evaluated their safety. Our objective was to evaluate the ADVr to SCIT in pediatric patients. <b><i>Methods:</i></b> We reviewed 786 clinical records with SCIT from 2005 to 2018, comparing the clinical characteristics of patients with ADVrs with SCIT versus a group of a similar number of patients who completed SCIT (control group, CG). The analysis of ADVrs was according to the World Allergy Organization (WAO) 2010 grading system by frequency analysis, survival curve, and log rank. <b><i>Results:</i></b> Of 786 patients, 106 (13.4%) presented ADVrs, and the patients with ADVr had sensitivity and immunotherapy with at least 2 allergens versus CG <i>p</i> < 0.001, containing a combination of standardized and nonstandardized allergens (<i>p</i> = 0.003). The ADVrs were in the buildup phase (<i>p</i> < 0.001). The survival curve showed that 50% had some reaction at 12 weeks of SCIT. The most frequent ADVr was grade 1 in 73/106 patients (68.8%) and grade 2 in 33/106 (31.1%). The log-rank analysis between the grades of the WAO grading system showed a statistically significant difference (<i>p</i> = 0.02). <b><i>Conclusions:</i></b> The SCIT is safe in pediatric patients. The ADVrs are infrequent, grade 1 being the most reported; however, at >12 weeks, the risk of ADVrs that involve 2 organs systems increases.
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GIACOMASSI, Priscila Célia. "ESTRATÉGIAS METACOGNITIVAS NAS PRÁTICAS DE ESTÁGIO SUPERVISIONADO." Trama 17, no. 41 (June 1, 2021): 103–11. http://dx.doi.org/10.48075/rt.v17i41.26867.
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Estratégias metacognitivas podem ser ferramentas muito úteis, se aplicadas no processo de estruturação e execução do estágio supervisionado, especialmente nos cursos de licenciatura. Por metacognição, compreende-se um tipo elaborado de gerenciamento sobre o próprio pensamento, uma atitude autorregulatória cujo traço distintivo consiste em promover a busca constante do “aprender a aprender”. O andaimento, a documentação e a organização de registros por meio de dossiês ou portfólios, os contratos de aprendizagem firmados entre estudantes e professores, a autoavaliação e o planejamento coletivo são algumas estratégias autorregulatórias que visam instrumentalizar o estudante em contexto de estágio, para que possa atuar nele de forma autônoma e participativa. Para tanto, o contexto que envolve todas as etapas do estágio, desde a sua concepção, passando pela implementação e avaliação, deve proporcionar uma atmosfera que instigue o aluno a conduzir as suas ações e decisões com segurança e assertividade. Consequentemente, o planejamento precisa ser entendido como “coletivo”, contemplando os principais envolvidos no processo, ou seja, os professores orientador e supervisor bem como o próprio acadêmico. Para chegar a esse ponto de maneira satisfatória, a configuração final do estágio não deve ser “engessada”, mas organizada, permitindo antecipar ao mesmo tempo problemas e alternativas para resolvê-los. Tal movimento não é viável se não houver articulação entre universidade e escola visando a um constante aprimoramento dos métodos e técnicas empregados no processo. Nessa perspectiva, além de cumprirem seu papel previsto em lei de associarem de forma eficiente os conhecimentos teóricos e o fazer docente, as práticas de estágio podem se constituir em situações propícias a reflexões, iniciativas, projetos e propostas de intervenção capazes de beneficiar os atores e cenários envolvidos nessa ação.Referências:ALCÂNTARA, Marcelo Silveira de. Metacognição e auto-regulação na graduação universitária: estratégias de estudo individual e ensino-aprendizagem em contexto de iniciação à expertise. 254 f. Tese (Doutorado em Educação) Universidade Católica de Brasília, Brasília, 2014.BRASIL. Lei de Diretrizes e Bases da Educação Nacional nº 9.394, de 20 de dezembro de 1996. Disponível em: http://www.planalto.gov.br/ccivil_03/leis/l9394.htm Acesso em: 28 jan. 2021.BRASIL. Lei nº 11.788, de 25 de setembro de 2008. Disponível em: http://www.planalto.gov.br/ccivil_03/_ato2007-2010/2008/lei/l11788.htm Acesso em: 29 jan. 2021.CALDERANO, Maria da Assunção. Docência compartilhada entre universidade e escola: formação no estágio curricular. São Paulo: FCC/SEP, 2014. Disponível em: http://publicacoes.fcc.org.br/ojs/index.php/textosfcc/issue/download/305/67 Acesso em: 29 jan. 2021.CARLBERG, Simone. Considerações. In.: O processo educativo: articulações possíveis frente à diversidade. São José dos Campos: Pulso, 2006, p. 106-108.CARLBERG, Simone; PILATTI, Elisangela; JUNGHANS, Marianne Kollarz. Portfólio: Instrumento-meio de educação. In.: O processo educativo: articulações possíveis frente à diversidade. São José dos Campos: Pulso, 2006, p. 111-128.CHAUÍ, Marilena de Souza. Ideologia e Educação: educação e sociedade. São Paulo: Cortez, 1980.HATTIE, John. Aprendizagem visível para professores: como maximizar o impacto da aprendizagem. (Trad.)Luís Fernando Marques Dorvillé. Porto Alegre: Penso: 2017.FAGUNDES, Gustavo. Educação Superior Comentada. A diferença entre as figuras de orientador e supervisor de estágio na educação superior. Ano 2 Nº 16 de 15 a 21 de julho de 2014. Disponível em: https://abmes.org.br/colunas/detalhe/1105/educacao-superior-comentada-%E2%80%93-a-diferenca-entre-as-figuras-de-orientador-e-supervisor-de-estagio-na-educacao-superior# Acesso em 31 jan. 2021.FLAVELL, John H. Metacognition and cognitive monitoring: A new area of cognitive-developmental inquiry. American Psychologist, v. 34, No. 10, 906-911, October, 1979. Disponível em:http://jwilson.coe.uga.edu/EMAT7050/Students/Wilson/Flavell%20(1979).pdf Acesso em: 26 abr. 2021.FREIRE, Paulo. Pedagogia da autonomia: Saberes necessários à prática educativa. São Paulo: Paz e Terra. 2009.PINTO, Rosimar Sabino; MARCOTTI, Paulo. Metacognição - uma proposta de intervenção psicopedagógica no Ensino Fundamental I. Revista de Pós-Graduação Multidisciplinar, São Paulo, v. 1, n. 4, p. 169-178, mar. 2018/set. 2018. Disponível em: https://www.fics.edu.br/index.php/rpgm/article/view/781/711 Acesso em: 28 jan. 2021.SANTOS, Denise. 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Disponível em: https://educere.bruc.com.br/cd2009/pdf/3174_1460.pdf Acesso em: 28 jan. 2021.Recebido em 01-02-2021Revisões requeridas em 15-04-2021Aceito em 10-05-2021