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Journal articles on the topic '200502 Health related to ageing'

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Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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1

Lim, Sahnah, Sadia Mohaimin, Deborah Min, Timothy Roberts, Young-Jin Sohn, Jazmine Wong, Ragavan Sivanesathurai, Simona C. Kwon, and Chau Trinh-Shevrin. "Alzheimer’s Disease and its Related Dementias among Asian Americans, Native Hawaiians, and Pacific Islanders: A Scoping Review." Journal of Alzheimer's Disease 77, no. 2 (September 15, 2020): 523–37. http://dx.doi.org/10.3233/jad-200509.

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Background: The Asian American, Native Hawaiian, and Pacific Islander (AANHPI) aging population is rapidly growing and the burden of Alzheimer’s disease and its related dementias (ADRD) will likely mirror this demographic growth. AANHPIs face significant barriers in obtaining timely ADRD diagnosis and services; yet little is known about ADRD in this population. Objective: The study objective is to conduct a systematic review on the published literature on ADRD among AANHPIs to identify gaps and priorities to inform future research and action plans. Methods: The systematic review was conducted following the PRISMA Protocol for Systematic Reviews. Co-author (TR), an experienced Medical Librarian, searched PubMed, EMBASE, PsycINFO, Cochrane Central of Clinical Trials, Ageline, and Web of Science for peer-reviewed articles describing ADRD among AANHPIs. The search was not limited by language or publication date. Each citation was reviewed by two trained independent reviewers. Conflicts were resolved through consensus. Results: The title/abstract and full texts of 1,447 unique articles were screened for inclusion, yielding 168 articles for analysis. Major research topics included prevalence, risk factors, comorbidities, interventions and outreach, knowledge and attitudes, caregiving, and detection tools. A limited number of studies reported on national data, on NHPI communities generally, and on efficacy of interventions targeting AANHPI communities. Conclusion: To our knowledge, this is the first systematic review on ADRD among AANHPI populations. Our review provides a first step in mapping the extant literature on ADRD among this underserved and under-researched population and will serve as a guide for future research, policy, and intervention.

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Koch, Melissa, Paul Stolee, Maggie MacNeil, Jacobi Elliott, Plinio Morita, Ayse Kuspinar, and Don Juzwishin. "Innovation processes for ageing-related health technologies." Healthcare Management Forum 34, no. 1 (July 8, 2020): 34–42. http://dx.doi.org/10.1177/0840470420936715.

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Innovative technologies offer potential benefits for the health and care needs of an ageing population, but the processes by which these innovations are developed and implemented are not well understood. As part of a Canadian research network focused on ageing and technology, we explored how technologies currently being developed to support older adults and their caregivers fare through the processes of innovation. We conducted a multiple case study focused on development of four technology products. Interviews were conducted with project members (n = 8) during site visits to the locations of the four cases, as well as with other key informants (n = 12). Directed coding, guided by the Accelerating Diffusion of Proven Technologies for Older Adults (ADOPT) model was used to analyse the data. Findings illustrate the complexities of innovation processes, including the challenges in developing a business case as well as benefits of a collaborative network.

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Algarni, F. S., D. P. Gross, A. Senthilselvan, and M. C. Battie. "Ageing workers with work-related musculoskeletal injuries." Occupational Medicine 65, no. 3 (March 10, 2015): 229–37. http://dx.doi.org/10.1093/occmed/kqu213.

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4

Stephens, Christine, and Uwe Flick. "Health and Ageing —Challenges for Health Psychology Research." Journal of Health Psychology 15, no. 5 (July 2010): 643–48. http://dx.doi.org/10.1177/1359105310368178.

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In the light of ageing populations, three general issues of health and ageing become relevant for research and intervention in health psychology: ageing in the general population, among those who are confronted with frailty and illness, and on the ageing experiences of specific populations. In all of these areas there is a need to understand the factors (such as social engagement) that promote well-being and compression of ageing in community or institutional dwelling elders, while being aware of the impact of ageism, inequalities and exclusion on different people’s access to health related policy resources and health care.

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Tuohy, Dympna. "176Older Women’s Experiences of Ageing and Health Related Issues." Age and Ageing 46, Suppl_3 (September 2017): iii1—iii12. http://dx.doi.org/10.1093/ageing/afx145.33.

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6

Kozakova, Michaela, and Carlo Palombo. "Vascular Ageing and Aerobic Exercise." International Journal of Environmental Research and Public Health 18, no. 20 (October 12, 2021): 10666. http://dx.doi.org/10.3390/ijerph182010666.

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Impairment of vascular function, in particular endothelial dysfunction and large elastic artery stiffening, represents a major link between ageing and cardiovascular risk. Clinical and experimental studies identified numerous mechanisms responsible for age-related decline of endothelial function and arterial compliance. Since most of these mechanisms are related to oxidative stress or low-grade inflammation, strategies that suppress oxidative stress and inflammation could be effective for preventing age-related changes in arterial function. Indeed, aerobic physical activity, which has been shown to improve intracellular redox balance and mitochondrial health and reduce levels of systemic inflammatory markers, also improves endothelial function and arterial distensibility and reduces risk of cardiovascular diseases. The present paper provides a brief overview of processes underlying age-related changes in arterial function, as well as the mechanisms through which aerobic exercise might prevent or interrupt these processes, and thus attenuate vascular ageing.

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Simionescu, Mihaela. "Health-related Determinants of Demographic Ageing in the European Union." Romanian Journal of Population Studies 14, no. 2 (December 2020): 111–28. http://dx.doi.org/10.24193/rjps.2020.2.05.

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Descatha, Alexis, Diane Cyr, Zakia Mediouni, and Marcel Goldberg. "Work-related premature ageing: old concept but emerging stakes." Occupational and Environmental Medicine 70, no. 9 (July 3, 2013): 675.2–675. http://dx.doi.org/10.1136/oemed-2013-101618.

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9

Cardoso, Carlos, Cláudia Afonso, and Narcisa M. Bandarra. "Dietary DHA and health: cognitive function ageing." Nutrition Research Reviews 29, no. 2 (November 21, 2016): 281–94. http://dx.doi.org/10.1017/s0954422416000184.

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AbstractDHA is a key nutritional n-3 PUFA and needs to be supplied by the human diet. DHA is found in significant amounts in the retinal and neuronal cell membranes due to its high fluidity. Indeed, DHA is selectively concentrated in the synaptic and retinal membranes. DHA is deemed to display anti-inflammatory properties and to reduce the risk of CVD. Consumption of larger amounts of DHA appears to reduce the risk of depression, bipolar disorder, schizophrenia and mood disorders. Conversely, it has been shown that loss of DHA from the nerve cell membrane leads to dysfunction of the central nervous system in the form of anxiety, irritability, susceptibility to stress, dyslexia, impaired memory and cognitive functions, and extended reaction times. DHA plays an important role in ensuring a healthy ageing, by thwarting macular degeneration, Alzheimer’s disease, and other brain disorders at the same time as enhancing memory and strengthening neuroprotection in general. A reduced level of DHA is associated with cognitive decline during ageing. Different mechanisms for this fundamental DHA role have been put forward. Namely, neuroprotectin D1, a DHA derivative, may support brain cell survival and repair through neurotrophic, anti-apoptotic, and anti-inflammatory signalling. Many of the effects of DHA on the neurological system may be related to signalling connections, thus leading to the study of the related signalolipidomics. Therefore, the present review will focus on the influence of DHA deficiency upon ageing, with specific emphasis upon neurological disorders related to cognitive function and mental health.

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10

Bäckström, B. "Health, Ageing Migrants and Care Strategies." Health, Culture and Society 8, no. 2 (December 17, 2015): 75–86. http://dx.doi.org/10.5195/hcs.2015.207.

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This article is the result of a study that seeks to understand the relationship between socio-economic conditions, health and active ageing. We identified the activities related to active ageing in relation to health, the strategies used in active ageing and their determinants. We chose a qualitative methodology using semi-structured interviews and data processing that consisted of thematic content analysis in interviews. We carried out this analysis in two socio-economic groups of elderly Cape Verdean men and women in both groups making up a total of 22 cases. The socio-economic group interferes directly in the affairs of active ageing rather than health issues. In the higher socio-economic group, status determines active ageing rather than health issues. It is evident that in the group with lower socio-economic conditions, the latter act in parallel with health conditions and both determine activities developed by older people.

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LINDGREN, ALETTE-MARIE, KURT SVÄRDSUDD, and GÖSTA TIBBLIN. "Factors Related to Perceived Health among Elderly People: The Albertina Project." Age and Ageing 23, no. 4 (1994): 328–33. http://dx.doi.org/10.1093/ageing/23.4.328.

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12

Nazarko, Linda. "Ageing and eczema." Nursing and Residential Care 24, no. 1 (January 2, 2022): 1–11. http://dx.doi.org/10.12968/nrec.2022.0003.

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Skin conditions are more common as people age, with approximately 70% of older people having a treatable skin condition. Ageing related changes to the skin and health conditions can make it difficult for older people to care for their skin, causing eczema to develop. An inability to care for age related skin conditions can lead to infection, discomfort and can affect the persons quality of life. This article explores how ageing affects the skin, how different types of eczema can develop and how these are managed.

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13

Hanly, Paul, Paul M. Walsh, Alan Ó Céilleachair, Mairead Skally, Anthony Staines, Kanika Kapur, Patricia Fitzpatrick, and Linda Sharp. "Work-Related Productivity Losses in an Era of Ageing Populations." Journal of Occupational and Environmental Medicine 55, no. 2 (February 2013): 128–34. http://dx.doi.org/10.1097/jom.0b013e3182820553.

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14

Chmielewski, Piotr Paweł. "Human ageing as a dynamic, emergent and malleable process: from disease-oriented to health-oriented approaches." Biogerontology 21, no. 1 (October 8, 2019): 125–30. http://dx.doi.org/10.1007/s10522-019-09839-w.

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Abstract Over the decades, biogerontology has matured as a scientific discipline. Currently, a number of theoretical frameworks are available to researchers when interpreting empirical data. Despite the great progress that has been made, a comprehensive understanding of biological processes that shape ageing is lacking. Senescence is a dynamic, plastic and highly complex metaphenomenon whose aetiology remains unclear. The paucity of information notwithstanding, some researchers promote ‘anti-ageing’ drugs and formulae every now and again. The rationale behind this concept is that ageing can be reduced to a mixture of biochemical reactions. Furthermore, the distinction between ageing and disease has been questioned on the grounds that ageing is the root of age-related diseases. It has been claimed that disease-oriented approaches can help delay ageing and prevent age-related diseases. Although these methods seem incongruous from an evolutionary standpoint, they become popular amongst the public. Moreover, if ageing is classified as a disease, this situation is likely to be exacerbated. Therefore, it is important to recognise the limitations of these reductionist and disease-oriented approaches. Only holistic and evidence-based strategies might be useful in slowing down ageing and preventing age-related diseases in the future.

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Ferri, Cleusa P. "Population Ageing in Latin America: Dementia and Related Disorders." Revista Brasileira de Psiquiatria 34, no. 4 (December 2012): 371–74. http://dx.doi.org/10.1016/j.rbp.2012.08.005.

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Hewitt, K. E., G. Carter, and J. Jancar. "Ageing in Down's Syndrome." British Journal of Psychiatry 147, no. 1 (July 1985): 58–62. http://dx.doi.org/10.1192/bjp.147.1.58.

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SummaryIn a group of 23 hospital patients aged over 50 with Down's syndrome, psychological testing indicated that significant intellectual deterioration, which was un-related to chronological age, sex, length of hospitalisation, or earlier mental age, had occurred in nine. Clinically, there was no evidence in any patient of active physical illness, focal neurological signs, or dementia, but significant associations were found between intellectual deterioration and decreased visual acuity, hearing loss, and macrocytosis.

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Walsh, P. N., T. Heller, N. Schupf, and H. van Schrojenstein Lantman-de Valk. "Healthy Ageing - Adults with Intellectual Disabilities: Women's Health and Related Issues." Journal of Applied Research in Intellectual Disabilities 14, no. 3 (August 2001): 195–217. http://dx.doi.org/10.1046/j.1468-3148.2001.00070.x.

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18

Shiels, Paul G., Sarah Buchanan, Colin Selman, and Peter Stenvinkel. "Allostatic load and ageing: linking the microbiome and nutrition with age-related health." Biochemical Society Transactions 47, no. 4 (August 15, 2019): 1165–72. http://dx.doi.org/10.1042/bst20190110.

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Abstract Ageing is a process of decline in physiological function and capability over time. It is an anticipated major burden on societal health-care costs due to an increasingly aged global population. Accelerated biological ageing is a feature of age-related morbidities, which also appear to share common underpinning features, including low-grade persistent inflammation, phosphate toxicity, diminished Nrf2 activity, a depleted metabolic capability, depressed mitochondrial biogenesis and a low diversity gut microbiome. Social, psychological, lifestyle and nutritional risk factors can all influence the trajectory of age-related health, as part of an individual's exposome, which reflects the interplay between the genome and the environment. This is manifest as allostatic (over)load reflecting the burden of lifestyle/disease at both a physiological and molecular level. In particular, age-related genomic methylation levels and inflammatory status reflect exposome differences. These features may be mediated by changes in microbial diversity. This can drive the generation of pro-inflammatory factors, such as TMAO, implicated in the ‘diseasome’ of ageing. Additionally, it can be influenced by the ‘foodome’, via nutritional differences affecting the availability of methyl donors required for maintenance of the epigenome and by the provision of nutritionally derived Nrf2 agonists. Both these factors influence age-related physiological resilience and health. This offers novel insights into possible interventions to improve health span, including a rage of emerging senotherapies and simple modifications of the nutritional and environmental exposome. In essence, the emerging strategy is to treat ageing processes common to the diseasome of ageing itself and thus preempt the development or progression of a range of age-related morbidities.

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Camfield, David A., Lauren Owen, Andrew B. Scholey, Andrew Pipingas, and Con Stough. "Dairy constituents and neurocognitive health in ageing." British Journal of Nutrition 106, no. 2 (February 22, 2011): 159–74. http://dx.doi.org/10.1017/s0007114511000158.

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Age-related cognitive decline (ARCD) and dementia are of increasing concern to an ageing population. In recent years, there has been considerable research focused on effective dietary interventions that may prevent or ameliorate ARCD and dementia. While a number of studies have considered the impact that dairy products may have on physiological health, particularly with regard to the metabolic syndrome and cardiovascular health, further research is currently needed in order to establish the impact that dairy products have in the promotion of healthy brain function during ageing. The present review considers the available evidence for the positive effects of dairy products on the metabolic syndrome and glucose regulation, with consideration of the implications for neurocognitive health. A literature search of current (September 2010) meta-analyses/reviews and original research regarding dairy products and cognition was conducted through SCOPUS using the following search terms for dairy consituents: dairy, milk, cheese, yoghurt, probiotics, whey protein, alpha lactalbumin, calcium, B-12, bioactive peptides and colostrinin (CLN). These search terms for dairy products were combined with the following search terms related to cognition and health: cognition, cognitive decline, dementia, Alzheimer's disease, metabolic syndrome, diabetes, insulin resistance and glucose regulation. Concerns regarding SFA and other fatty acids found in dairy products are also reviewed in relation to different forms of dairy products. The review also considers recent evidence for positive neurocognitive effects associated with bioactive peptides, CLN and proline-rich polypeptides, α-lactalbumin, vitamin B12, calcium and probiotics. Future directions for the extraction and purification of beneficial constituents are also discussed. It is concluded that low-fat dairy products, when consumed regularly as part of a balanced diet, may have a number of beneficial outcomes for neurocognitive health during ageing.

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Lewis, S., L. Edwards, J. Glasbey, and A. Johansen. "9MEASURING HEALTH-RELATED QUALITY OF LIFE IN HIP FRACTURE - A PILOT STUDY." Age and Ageing 46, suppl_1 (May 2017): i1—i22. http://dx.doi.org/10.1093/ageing/afx055.9.

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21

Morimoto, T. "Caregiver burden and health-related quality of life among Japanese stroke caregivers." Age and Ageing 32, no. 2 (March 1, 2003): 218–23. http://dx.doi.org/10.1093/ageing/32.2.218.

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Sitoh, Y. Y. "Proxy assessment of health-related quality of life in the frail elderly." Age and Ageing 32, no. 4 (July 1, 2003): 459. http://dx.doi.org/10.1093/ageing/32.4.459.

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23

Holt, E. W., P. Muntner, C. J. Joyce, L. Webber, and M. A. Krousel-Wood. "Health-related quality of life and antihypertensive medication adherence among older adults." Age and Ageing 39, no. 4 (May 31, 2010): 481–87. http://dx.doi.org/10.1093/ageing/afq040.

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24

Hess, Thomas M. "Ageing-related influences on personal need for structure." International Journal of Behavioral Development 25, no. 6 (November 2001): 482–90. http://dx.doi.org/10.1080/01650250042000429.

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The need for structure construct was examined in relation to adult age using the Personal Need for Structure scale (PNS; M.M. Thompson, M.E. Naccarato, & K. Parker, 1989). The results of a series of confirmatory factor analyses indicated that the two intercorrelated-factor structure of the PNS scale held up well across individuals aged 21 to 85, validating its use for the examination of ageing effects. Structural equation modelling analyses found that ageing was associated with lower levels of physical health and cognitive skill, which in turn were related to higher PNS scores. It was also found, however, that the impact of reductions in these resources on need for structure were counteracted by high levels of social activity and emotional health. The argument is made that ageing-related changes in personal resources impact everyday behaviour through changes in motivation, such as need for structure.

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Rocha, Nelson Pacheco, Milton Rodrigues dos Santos, Margarida Cerqueira, and Alexandra Queirós. "Mobile Health to Support Ageing in Place." International Journal of E-Health and Medical Communications 10, no. 3 (July 2019): 1–21. http://dx.doi.org/10.4018/ijehmc.2019070101.

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The study reported in this article aimed to identify: i) the most relevant application domains of mHealth to support older adults in their domiciles; ii) the most relevant chronic conditions of older adults, whose management is being supported by mHealth; iii) the characteristics, outcomes and impacts of mHealth tools that might support older adults in their domiciles. The method of a systematic review of reviews and meta-analyses was performed based on a search of the literature. The result of a total of 66 reviews and meta-analyses across several chronic diseases were retrieved. These studies compare mHealth interventions with usual care. The conclusion is that mHealth interventions have positive effects on various health related outcomes, but further research is required to allow their incorporation in the clinical practice.

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Kulminski, A. M., K. G. Arbeev, I. V. Culminskaya, S. V. Ukraintseva, K. Christensen, and A. I. Yashin. "Health-Related Phenotypes and Longevity in Danish Twins." Journals of Gerontology Series A: Biological Sciences and Medical Sciences 64A, no. 1 (January 1, 2009): 1–8. http://dx.doi.org/10.1093/gerona/gln051.

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27

Edwards, James R. "Musculoskeletal Ageing—Dietary Modification of Longevity Mechanisms to Improve Skeletal Health." Proceedings 11, no. 1 (May 24, 2019): 38. http://dx.doi.org/10.3390/proceedings2019011038.

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Ageing is inextricably linked to a deterioration of the musculoskeletal system. This suggests factors governing lifespan might also impact the maintenance of skeletal integrity throughout life. The Oxford Musculoskeletal Ageing group studies the causes and consequences of skeletal ageing. Recent findings indicate dietary constituents (polyphenols, omega 3 fatty acids, polyamines) have the potential to activate longevity mechanisms in vitro and prevent the onset of age-related disorders in vivo. Alterations in RedOx mediators, autophagic flux, sirtuin enzymes and senescence all contribute to an inter-linked ageing nexus manipulated by diet, to maintain health throughout life.

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Ryg, Jesper. "152 Fall-Related Injuries – using the Nationwide Population based Danish National Health Registers." Age and Ageing 48, Supplement_4 (December 2019): iv34—iv39. http://dx.doi.org/10.1093/ageing/afz164.152.

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Abstract One-third of the population ≥65 years of age fall at least once a year. Fall related injuries including fragility fractures are common causes of hospital admission and associated with high morbidity, mortality, and cost to society. The ageing population poses a significant challenge to the healthcare systems. Therefore, studies are warranted that enables focus on specific areas in need of preventive efforts. The aim of this talk is to give an overview of the importance of falls and fractures, to review the unique possibilities of conducting epidemiological studies using nationwide population based registers, and to present results from studies on fall related injuries. Examples of presented results includes “Fall injuries requiring hospital admission”, “Cardiovascular drugs and risk of fragility fractures”, and “Subsequent fractures following first fracture admission.

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Min, K. b., and J. y. Min. "Health-related quality of life is associated with stroke deficits in older adults." Age and Ageing 44, no. 4 (May 20, 2015): 700–704. http://dx.doi.org/10.1093/ageing/afv060.

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Sorensen, Lene, Julie A. Stokes, David M. Purdie, Michael Woodward, and Michael S. Roberts. "Medication management at home: medication-related risk factors associated with poor health outcomes." Age and Ageing 34, no. 6 (November 1, 2005): 626–32. http://dx.doi.org/10.1093/ageing/afi202.

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Patel, M. D., K. Tilling, E. Lawrence, A. G. Rudd, C. D. A. Wolfe, and C. McKevitt. "Relationships between long-term stroke disability, handicap and health-related quality of life." Age and Ageing 35, no. 3 (May 1, 2006): 273–79. http://dx.doi.org/10.1093/ageing/afj074.

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Stevenson, Jennifer M., J. Graham Davies, and Finbarr C. Martin. "Medication-related harm: a geriatric syndrome." Age and Ageing 49, no. 1 (October 28, 2019): 7–11. http://dx.doi.org/10.1093/ageing/afz121.

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Abstract The WHO Global Patient Safety Challenge: Medication Without Harm recognises medication-related harm (MRH) as a global public health issue. Increased life-expectancy coupled with multimorbidity and polypharmacy leads to an increased incidence of MRH, especially in older adults: at a cost of approximately £400 million to the National Health Service (NHS) in England. Harm from medicines has long been recognised by geriatricians, and strategies have been developed to mitigate harm. In general, these have focused on the challenges of polypharmacy and appropriateness of medicines, but impact on the quality of life, clinical and economic outcomes has been variable and often disappointing. The problem of MRH in older adults will continue to grow unless a new approach is adopted. Emerging evidence suggests that we need to take a broader approach as described in our conceptual model, where well-recognised physiological changes are incorporated, as well as other rarely considered psychosocial issues that influences MRH. Parallels may be drawn between this approach and the management of geriatric syndromes. We propose there must be a greater emphasis on MRH, and it, of itself, should be considered as a geriatric syndrome, to bring the spotlight onto the problem and to send a clear signal from geriatric experts that this is an important issue that needs to be addressed using a co-ordinated and tailored approach across health and social care boundaries. This requires a more proactive approach to monitor and review the medicines of older adults in response to their changing need.

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Hao, Xiuqi, Yuehan Yang, Xiaotong Gao, and Tao Dai. "Evaluating the Effectiveness of the Health Management Program for the Elderly on Health-Related Quality of Life among Elderly People in China: Findings from the China Health and Retirement Longitudinal Study." International Journal of Environmental Research and Public Health 16, no. 1 (January 3, 2019): 113. http://dx.doi.org/10.3390/ijerph16010113.

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The world’s rapidly aging population brings serious challenges which could be addressed by changes in behaviour and policy that promote good health in older age. However, these cheap and simple interventions are not available in many countries. China is one of the fastest-ageing countries in the world. The health management programs for the elderly in basic public health services was introduced by the government to promote the health of the elderly in China and address the challenges related to ageing. However, the effectiveness of the program is uncertain. So, we use a propensity score matching difference-in-difference (PSM-DID) model to analyse the causal effect of the health management program for the elderly in basic public health services on the health-related quality of life (HRQoL) of the elderly in China. The result shows that the program has improved the physical health of the elderly but has had no significant impact on mental health. Expanding the program to cover mental health could further benefit the HRQoL of the elderly. The program is a cost-effective approach to tackle the challenges of ageing and is a good example for other developing countries facing the same ageing challenges.

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Muirhead, V. E., W. Marcenes, and D. Wright. "Do health provider-patient relationships matter? Exploring dentist-patient relationships and oral health-related quality of life in older people." Age and Ageing 43, no. 3 (November 25, 2013): 399–405. http://dx.doi.org/10.1093/ageing/aft183.

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35

Hulme, C. "Using the EQ-5D to assess health-related quality of life in older people." Age and Ageing 33, no. 5 (September 1, 2004): 504–7. http://dx.doi.org/10.1093/ageing/afh178.

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Schaafsma, F. G., S. E. Kurrle, S. Quine, K. Lockwood, and I. D. Cameron. "Wearing hip protectors does not reduce health-related quality of life in older people." Age and Ageing 41, no. 1 (September 6, 2011): 121–25. http://dx.doi.org/10.1093/ageing/afr123.

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37

MacNee, William, Roberto A. Rabinovich, and Gourab Choudhury. "Ageing and the border between health and disease." European Respiratory Journal 44, no. 5 (October 16, 2014): 1332–52. http://dx.doi.org/10.1183/09031936.00134014.

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Ageing is associated with a progressive degeneration of the tissues, which has a negative impact on the structure and function of vital organs and is among the most important known risk factors for most chronic diseases. Since the proportion of the world’s population aged >60 years will double in the next four decades, this will be accompanied by an increased incidence of chronic age-related diseases that will place a huge burden on healthcare resources.There is increasing evidence that many chronic inflammatory diseases represent an acceleration of the ageing process. Chronic pulmonary diseases represents an important component of the increasingly prevalent multiple chronic debilitating diseases, which are a major cause of morbidity and mortality, particularly in the elderly. The lungs age and it has been suggested that chronic obstructive pulmonary disease (COPD) is a condition of accelerated lung ageing and that ageing may provide a mechanistic link between COPD and many of its extrapulmonary effects and comorbidities. In this article we will describe the physiological changes and mechanisms of ageing, with particular focus on the pulmonary effects of ageing and how these may be relevant to the development of COPD and its major extrapulmonary manifestations.

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Crabb, Rebecca M., Samantha Rafie, and Kenneth R. Weingardt. "Health-Related Internet Use in Older Primary Care Patients." Gerontology 58, no. 2 (2012): 164–70. http://dx.doi.org/10.1159/000329340.

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39

Bugiani, Orso. "Alzheimer’s disease: ageing-related or age-related? New hypotheses from an old debate." Neurological Sciences 32, no. 6 (May 13, 2011): 1241–47. http://dx.doi.org/10.1007/s10072-011-0614-4.

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Anderton, Brian H. "Changes in the ageing brain in health and disease." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 352, no. 1363 (December 29, 1997): 1781–92. http://dx.doi.org/10.1098/rstb.1997.0162.

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The brains of individuals, who are cognitively normal, show age–related changes that include an overall reduction in brain volume and weight, which are associated with gyral atrophy and widening of the sulci of the cerebral cortex, and enlargement of the brain ventricles. These changes are partly the result of nerve cell loss but accurate estimates of neuronal loss are notoriously difficult to make. Microscopically, there are increasing amounts of the age–related pigment, lipofuscin, granulovacuolar degeneration in neurons, Hirano bodies, variable amounts of diffuse deposits of β–amyloid in the parenchyma, the presence of neurofibrillary tangles mainly confined to the hippocampus and amygdala, and sparse numbers of senile plaques in these brain regions and also in other cortical areas. Of these changes, neurofibrillary tangles and senile plaques are the neuropathological hallmark of Alzheimer's disease in which they are more abundant and widespread. Alzheimer's disease has therefore been regarded as accelerated brain ageing; however, the realization that there is a strong genetic contribution to developing the disease at least implies that it may not be the inevitable, even if frequent, consequence of old age. Understanding the molecular basis of plaque and tangle formation is advancing greatly and is the main focus of research into the cellular and molecular changes observed in the ageing brain.

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Glintborg, D., T. L. Nielsen, K. Wraae, D. Hougaard, C. Gudex, K. Brixen, and M. Andersen. "The relationship between health-related quality of life, obesity and testosterone levels in older men." Age and Ageing 43, no. 2 (December 29, 2013): 280–84. http://dx.doi.org/10.1093/ageing/aft203.

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Van den Bogaert, Sarah, Melissa Ceuterick, and Piet Bracke. "The silver lining of greying: Ageing discourses and positioning of ageing persons in the field of social health insurance." Health: An Interdisciplinary Journal for the Social Study of Health, Illness and Medicine 24, no. 2 (September 12, 2018): 169–86. http://dx.doi.org/10.1177/1363459318800171.

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Contemporary ageing discourses and policies perceive being active as the key to a good later life and thereby focus on individual responsibility and self-care. Drawing on website articles and press releases of Belgian sickness fund agencies, this study analyses the ageing discourses and positioning of ageing persons of these organisations. A discourse analysis was performed using positioning theory to analyse how sickness fund agencies discursively construct the ageing process and position ageing persons, and to investigate how these positioning acts are related to sickness fund agencies’ roles as social insurer, social movement, social entrepreneur and private insurer. Our results reveal three storylines on ageing; ageing as a medical problem, ageing as a new stage in life and ageing as a natural life process. These storylines are applied to construct ageing and position ageing persons in different ways. Depending on their role, sickness fund agencies take on a different position drawing on these different storylines. We also show how these storylines reproduce the moral framework on how to age well and thereby disempower ageing persons. Our results underline the importance of multidimensional perspectives on ageing.

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Maia, Ana Catarina, Paulo Nogueira, Maria Adriana Henriques, Carla Farinha, and Andreia Costa. "Ageing and Long-Term Informal Care: The Reality of Two Countries in Europe: Denmark and Portugal." International Journal of Environmental Research and Public Health 19, no. 17 (August 31, 2022): 10859. http://dx.doi.org/10.3390/ijerph191710859.

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The knowledge of long-term informal care is particularly interesting for social and health measures related to ageing. This study aims to analyze how Portugal differs from Denmark regarding long-term informal care, specifically referring to personal care received by older people. A cross-sectional study was developed in Portugal and Denmark through the Survey of Health, Ageing and Retirement in Europe (SHARE) in 2015, with a total of 2891 participants. Descriptive statistics and logistic regressions were performed. The findings suggest a significant association for older people from Portugal who receive long-term informal care from non-household caregivers and household caregivers. Moreover, as they age and are from Portugal, their availability to receive long-term informal care from non-household caregivers increases. Furthermore, older people in Portugal are more likely to receive long-term informal care from a household caregiver. It is important to take a closer look at long-term informal care in both countries and think about healthy ageing policies in the current context of the ageing population. This study provides knowledge about disaggregated health data on ageing in the European region, helping to fill research gaps related to older people.

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Mohamad Yunus, Noor’ain, Noor Hazilah Abd Manaf, Azura Omar, Nurita Juhdi, Mohd Azhadi Omar, and Mohmad Salleh. "Attitude Towards Ageing and Perceived Health Status among the Elderly in Malaysia." ADVANCES IN BUSINESS RESEARCH INTERNATIONAL JOURNAL 2, no. 2 (December 30, 2016): 27. http://dx.doi.org/10.24191/abrij.v2i2.10022.

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There is an increasing number of older people globally, thus it is essential to build knowledge of how older people view their own ageing, considering their health related circumstances. However, limited attention has been given to attitude towards ageing, particularly in Malaysia. The purpose of this study is to examine the relationship between self- perception of ageing and perceived health status in adults aged 60 years and above. This study is primarily conducted via survey among the elderly patients who are 60 years old and above, who are using the services at public hospitals in Peninsular Malaysia. The ‘Attitudes towards ageing’ questionnaire was used to measure participants’ perception of ageing, while perceived health status was measured using questions from the Study of Global Ageing and Adult Health (SAGE) developed by World Health Organization(WHO). All items in both questionnaires were measured on a 5-point Likert-scale. The findings reveal that positive attitudes to ageing were associated with health status in older adults. The research contributes to greater understanding of the attitudes among the elderly towards ageing and their perceived health status. Understanding these associations may help healthcare providers and policy makers consider strategies to enhance the quality of life of the elderly.

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Vincent, Maria. "Intellectual disability and ageing." InnovAiT: Education and inspiration for general practice 13, no. 11 (September 17, 2020): 669–75. http://dx.doi.org/10.1177/1755738020949572.

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As people with intellectual disability are now living to a greater age, promoting and maintaining health, recognising disease and co-ordinating pathways of patient care, become increasingly important. The GP needs to understand problems associated with increased longevity in this complex patient group and to know how to support ageing patients. This article will provide background knowledge, advice and resources to better understand common age-related problems in people with intellectual disability and to support patients and their families in managing these issues.

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Finkelstein, Adi, Ariel Tenenbaum, and Yaacov G. Bachner. "‘I will never be old’: adults with Down syndrome and their parents talk about ageing-related challenges." Ageing and Society 40, no. 8 (March 21, 2019): 1788–807. http://dx.doi.org/10.1017/s0144686x19000266.

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AbstractThe life expectancy of people with Down syndrome (DS) has increased significantly over the last few decades. Consequently, they and their families face new ageing-related challenges, the first signs of which appear in people with DS around the age of 30. The goal of this study was to explore the perceptions of adults with DS regarding their own and their parents’ ageing and end of life, and to examine the views and concerns of the parents regarding the ageing of their children with DS. The unique approach used in our study was to convene not only the ageing people with DS but also their parents, to discuss the subject together. A total of 33 people with DS participated in the study. Most of them were interviewed with one or two parents. Participants with DS found it difficult to talk about their own old age and addressed the issue mainly through the decline in the functioning of an older person they knew. The parents emphasised the changes needed in terms of the official regulations, so as to ensure that their children with DS age with dignity and quality of life. Our study identifies the increasingly pressing need to prepare adults with DS for their own and their parents’ ageing and end of life in a timely manner.

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Roe, Lorna, Aisling O’Halloran, Rose Anne Kenny, Daniel Carey, and Charles Normand. "158Frailty-related Outcomes and Health Care USe (FOCUS): Evidence from The Irish Longitudinal Study on Ageing." Age and Ageing 47, suppl_5 (September 1, 2018): v13—v60. http://dx.doi.org/10.1093/ageing/afy140.119.

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Goudzwaard, Jeannette A., Marjo J. A. G. de Ronde-Tillmans, Fleurance E. D. van Hoorn, Eline H. C. Kwekkeboom, Mattie J. Lenzen, Maarten P. H. van Wiechen, Joris F. W. Ooms, et al. "Impact of frailty on health-related quality of life 1 year after transcatheter aortic valve implantation." Age and Ageing 49, no. 6 (May 18, 2020): 989–94. http://dx.doi.org/10.1093/ageing/afaa071.

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Abstract Background Transcatheter aortic valve implantation (TAVI) brings symptom relief and improvement in health-related quality of life (HRQoL) in the majority of patients treated for symptomatic, severe aortic stenosis. However, there is a substantial group of patients that do not benefit from TAVI. The aim of this study is to investigate the impact of frailty on HRQoL 1 year after TAVI. Methods The TAVI Care & Cure Program is an ongoing, prospective, observational study including patients referred for TAVI to our institution. A comprehensive geriatric assessment was performed to evaluate existence of frailty using the Erasmus Frailty Score (EFS). HRQoL was assessed using the EQ-5D-5 L at baseline and 1 year after TAVI. Results 239 patients underwent TAVI and completed HRQoL assessment 1 year after TAVI. Seventy (29.3%) patients were classified as frail (EFS ≥ 3). In non-frail patients, the EQ-5D-5 L index did not change (0.71(± 0.22) to 0.68(± 0.33) points, P = 0.22); in frail patients, the EQ-5D-5 L index decreased from 0.55(±0.26) to 0.44 points (±0.33) (P = 0.022). Frailty was an independent predictor of deteriorated HRQoL 1 year after TAVI (OR 2.24, 95% CI 1.07–4.70, P = 0.003). In frail patients, the absence of peripheral artery disease (OR 0.17, 95% 0.05–0.50, P = 0.001) and renal dysfunction (OR 0.13, 95% CI 0.04–0.41, P = <0.001) at baseline was associated with improved HRQoL 1 year after TAVI. Conclusion Frailty is associated with deterioration of HRQoL 1 year after TAVI. Notably, HRQoL did improve in frail patients with no peripheral arterial disease or renal impairment at baseline.

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Sayer, Avan Aihie, Holly E. Syddall, Helen J. Martin, Elaine M. Dennison, Helen C. Roberts, and Cyrus Cooper. "Is grip strength associated with health-related quality of life? Findings from the Hertfordshire Cohort Study." Age and Ageing 35, no. 4 (May 11, 2006): 409–15. http://dx.doi.org/10.1093/ageing/afl024.

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Peel, Nancye May, Roderick John McClure, and Joan Katherine Hendrikz. "Health-protective behaviours and risk of fall-related hip fractures: a population-based case–control study." Age and Ageing 35, no. 5 (June 13, 2006): 491–97. http://dx.doi.org/10.1093/ageing/afl056.

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