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Journal articles on the topic '2,5-HEXANEDIONE'

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Published: 9 March 2023

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1

Boekelheide, Kim, Shawna L. Fleming, Theresa Allio, Michelle E. Embree-Ku, Susan J. Hall, Kamin J. Johnson, Eun Ji Kwon, et al. "2,5-HEXANEDIONE-INDUCEDTESTICULARINJURY." Annual Review of Pharmacology and Toxicology 43, no. 1 (April 2003): 125–47. http://dx.doi.org/10.1146/annurev.pharmtox.43.100901.135930.

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2

Hernandez-Viadel, Mari Luz, Regina Rodrigo, and Vicente Felipo. "Selective regional alterations in the content or distribution of neuronal and glial cytoskeletal proteins in brain of rats chronically exposed to 2,5-hexanedione." Toxicology and Industrial Health 18, no. 7 (August 2002): 333–41. http://dx.doi.org/10.1191/0748233702th154oa.

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Hexane is used in many industrial processes and induces neurotoxic effects in the central and peripheral nervous system. Hexane is metabolized to 2,5-hexanedione, which is the neurotoxic agent. Continued exposure to hexane or 2,5-hexanedione results in loss of sensorial and motor function in arms and legs and to alterations in axonal neurofilament proteins. The effects of 2,5-hexanedione on different cytoskeletal proteins in different brain areas have not been studied in detail. The aim of this work was to study the effects of chronic exposure of rats to 2,5-hexanedione (1% in the drinking water) on tubulin, neurofilament NF-L, microtubule-associated protein MAP-2, and on glial fibrillary acidic protein (GFAP), in cerebellum, hippocampus and cerebral cortex. The amount of each protein was determined by immunoblotting and its distribution was analysed by immunohistochemistry. The results obtained show a regional selectivity in the 2,5-hexanedione effects on cytoskeletal proteins. NF-L content decreased in all brain areas. MAP-2 decreased in cerebellum and hippocampus and tubulin decreased only in cerebellum. GFAP decreased only in cerebral cortex, but its distribution was altered in cerebellum, with increased content in the granular layer and decreased content in the molecular layer. The area most affected was the cerebellum, where all the proteins analysed were altered. These cytoskeletal proteins alterations may impair the transfer of information involved in the regulation by the cerebellum of motor function and contribute to the altered motor performance in rats exposed to 2,5-hexanedione and humans exposed to hexane.
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3

Towell, Todd L., Linda Shell, Karen Dyer Inzana, Bernard S. Jortner, and Marion Ehrich. "Electrophysiological Detection of the Neurotoxic Effects of Acrylamide and 2,5-Hexanedione on the Rat Sensory System." International Journal of Toxicology 19, no. 3 (May 2000): 187–93. http://dx.doi.org/10.1080/10915810050074955.

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Brain stem auditory evoked potentials (BAEP) and somatosensory evoked potentials (SEP), recorded from subcutaneously placed electrodes in anesthetized rats, were used to detect neurotoxic effects of acrylamide and 2,5-hexanedione on the sensory nervous system. Both neurotoxicants were administered for 21 days by the intraperitoneal route, using dosages of 20 mg/kg/day for acrylamide and 350 mg/kg/day for 2,5-hexanedione. Recordings were made before and 1, 2, and 3 weeks after dosing was initiated. Both food-restricted and ad libitum-fed rats served as controls. Results demonstrated that SEP waveforms generated in rats were sufficiently variable that differences among the groups were not detected. However, BAEP latencies were longer than those seen in control rats after 3 weeks of acrylamide treatment and after both 2 and 3 weeks of 2,5-hexanedione treatment. The effects of 2,5-hexanedione were more pronounced than those of acrylamide, and increased with length of the dosing period.
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4

Zhang, Yue, Wei Ling Li, Shuang Zong, Hong Xia Du, and Xian Xian Shi. "Clean Synthesis Process of 2,5-Hexanedione." Advanced Materials Research 518-523 (May 2012): 3947–50. http://dx.doi.org/10.4028/www.scientific.net/amr.518-523.3947.

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A circulating production of 2,5-hexanedione from 2,5-dimethylfuran was studied. The results showed that new technology reduced the environmental pollution, the cost of production and the difficulty of product separation, simultaneously, improved the purity of product. The method requires simple equipment, mild reaction conditions, involved in the safe operation easy, suitable for industrial production, is a more reasonable and more convenient synthesis of circular economy of 2,5-hexanedione method.
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5

Pyle, S. J., V. Amarnath, D. G. Graham, and D. C. Anthony. "THE EFFECTS OF 2,5-HEXANEDIONE AND 3-ACETYL-2,5-HEXANEDIONE ON NEUROFILAMENT TRANSPORT." Journal of Neuropathology and Experimental Neurology 49, no. 3 (May 1990): 294. http://dx.doi.org/10.1097/00005072-199005000-00106.

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6

Zhou, Huacong, Jinliang Song, Qinglei Meng, Zhenhong He, Zhiwei Jiang, Baowen Zhou, Huizhen Liu, and Buxing Han. "Cooperative catalysis of Pt/C and acid resin for the production of 2,5-dimethyltetrahydrofuran from biomass derived 2,5-hexanedione under mild conditions." Green Chemistry 18, no. 1 (2016): 220–25. http://dx.doi.org/10.1039/c5gc01741f.

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7

Zhang, Jie, Suqi Zhang, Ci Peng, Yuhang Chen, Zhiyong Tang, and Qing Wu. "Continuous synthesis of 2,5-hexanedione through direct C–C coupling of acetone in a Hilbert fractal photo microreactor." Reaction Chemistry & Engineering 5, no. 12 (2020): 2250–59. http://dx.doi.org/10.1039/d0re00247j.

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8

DeCaprio, Anthony P., Elizabeth A. Kinney, and Richard M. LoPachin. "Comparative Covalent Protein Binding of 2,5-Hexanedione and 3-Acetyl-2,5-Hexanedione in the Rat." Journal of Toxicology and Environmental Health, Part A 72, no. 14 (June 30, 2009): 861–69. http://dx.doi.org/10.1080/15287390902959508.

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9

Sabri, Mohammad I. "Effect of 2,5-hexanedione and 3,4-dimethyl-2,5-hexanedione on retrograde axonal transport in sciatic nerve." Neurochemical Research 17, no. 9 (September 1992): 835–39. http://dx.doi.org/10.1007/bf00993258.

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10

DeCaprio, Anthony P., Robert G. Briggs, Stephen J. Jackowski, and James C. S. Kim. "Comparative neurotoxicity and pyrrole-forming potential of 2,5-hexanedione and perdeuterio-2,5-hexanedione in the rat." Toxicology and Applied Pharmacology 92, no. 1 (January 1988): 75–85. http://dx.doi.org/10.1016/0041-008x(88)90229-3.

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11

Karakaya, A., B. Yücesoy, S. Burgaz, HU Sabir, and AE Karakaya. "Some immunological parameters in workers occupationally exposed to n-hexane." Human & Experimental Toxicology 15, no. 1 (January 1996): 56–58. http://dx.doi.org/10.1177/096032719601500110.

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1 To estimate the quantitative relation between exposure to airborne n-hexane and various markers of immune function, 35 male workers were examined and compared with unexposed controls. 2 Urinary 2,5-hexanedione concentrations were signifi cantly higher in the exposed group than in the unexposed. 3 A significant suppression was observed in the serum immunoglobulin (IgG, IgM and IgA) levels between two populations. Also, a significant correlation was found between urinary 2,5-hexanedione concentrations and serum Ig level of the exposed group. 4 No significant difference between white blood cell counts was found in the two groups.
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12

Guan, Huai, Hua Piao, Zhiqiang Qian, Xueying Zhou, Yijie Sun, Chenxue Gao, Shuangyue Li, and Fengyuan Piao. "2,5-Hexanedione induces autophagic death of VSC4.1 cells via a PI3K/Akt/mTOR pathway." Molecular BioSystems 13, no. 10 (2017): 1993–2005. http://dx.doi.org/10.1039/c7mb00001d.

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13

Qingjun Liu, Huawei Duan, Yufei Dai, Yong Niu, Hong Chen, Qing Liu, Ping Bin, and Yuxin Zheng. "The effect of 2,5-hexanedione on permeability of blood-nerve barrier in rats." Human & Experimental Toxicology 29, no. 6 (January 5, 2010): 497–506. http://dx.doi.org/10.1177/0960327109357213.

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To explore the effect of 2,5-hexanedione on permeability of blood-nerve barrier, adult Wistar rats were administered with 400 mg.kg—1.d— 1 2,5-hexanedione to establish animal model of 2,5-hexnedione neuropathy. Evans blue was injected through left femoral vein of the rats after the model had been established. The distribution of fluorescence in sciatic-tibial nerve was observed and assessed. For the transverse sections of sciatic-tibial nerves, the average fluorescence intensity of proximal section was stronger (p < .01) than those of intermediate and distal sections and the average fluorescence intensity of intermediate section was stronger (p < .01) than that of distal section in the intoxicated group. In the control, the weak fluorescence was shown, and average fluorescence intensity of distal section was stronger (p < .05) than that of proximal section. The average fluorescence intensity of proximal, intermediate and distal sections in the intoxicated group was stronger (p < .01) than those of the corresponding sections in the control. For the longitudinal sections of sciatic-tibial nerves, fluorescence was observed in both proximal and distal sections in the intoxicated group. The fluorescence intensity of distal section in the control was weak and almost no fluorescence was shown in the proximal section. The permeability of blood-nerve barrier could be increased by 2,5-hexanedione.
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14

Roylance, John J., and Kyoung-Shin Choi. "Electrochemical reductive biomass conversion: direct conversion of 5-hydroxymethylfurfural (HMF) to 2,5-hexanedione (HD) via reductive ring-opening." Green Chemistry 18, no. 10 (2016): 2956–60. http://dx.doi.org/10.1039/c6gc00533k.

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15

Sacia, Eric R., Matthew H. Deaner, Ying “Lin” Louie, and Alexis T. Bell. "Synthesis of biomass-derived methylcyclopentane as a gasoline additive via aldol condensation/hydrodeoxygenation of 2,5-hexanedione." Green Chemistry 17, no. 4 (2015): 2393–97. http://dx.doi.org/10.1039/c4gc02292k.

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16

Wozniak, Bartosz, Sergey Tin, and Johannes G. de Vries. "Bio-based building blocks from 5-hydroxymethylfurfural via 1-hydroxyhexane-2,5-dione as intermediate." Chemical Science 10, no. 24 (2019): 6024–34. http://dx.doi.org/10.1039/c9sc01309a.

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17

Ogata, Masana, Tomoko Iwamoto, and Toyohiro Taguchi. "Urinary 2,5-hexanedione assay involving its conversion to 2,5-dimethylpyrrole." International Archives of Occupational and Environmental Health 62, no. 8 (April 1991): 561–68. http://dx.doi.org/10.1007/bf00381109.

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18

Cosimbescu, Lelia, Kristen B. Campbell, Senthil Subramanian, Marie S. Swita, Naijia Hao, Cameron M. Moore, Karthikeyan K. Ramasamy, et al. "The properties of bicyclic and multicyclic hydrocarbons as bio-derived compression ignition fuels that can be prepared via efficient and scalable routes from biomass." Sustainable Energy & Fuels 5, no. 12 (2021): 3143–59. http://dx.doi.org/10.1039/d0se01742f.

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19

Upreti, Raj K., and Ravi Shanker. "2,5-Hexanedione-induced immunomodulatory effect in mice." Environmental Research 43, no. 1 (June 1987): 48–59. http://dx.doi.org/10.1016/s0013-9351(87)80056-7.

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20

liu, Fei, Maïté Audemar, Karine De Oliveira Vigier, Jean-Marc Clacens, Floryan De Campo, and François Jérôme. "Combination of Pd/C and Amberlyst-15 in a single reactor for the acid/hydrogenating catalytic conversion of carbohydrates to 5-hydroxy-2,5-hexanedione." Green Chem. 16, no. 9 (2014): 4110–14. http://dx.doi.org/10.1039/c4gc01158a.

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21

OGATA, Masana, Tomoko IWAMOTO, and Toyohiro TAGUCHI. "Determination of urinary 2,5-hexanedione by its conversion to 2,5-dimethylpyrrole." INDUSTRIAL HEALTH 28, no. 3 (1990): 125–31. http://dx.doi.org/10.2486/indhealth.28.125.

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22

Ren, Dezhang, Zhiyuan Song, Lu Li, Yunjie Liu, Fangming Jin, and Zhibao Huo. "Production of 2,5-hexanedione and 3-methyl-2-cyclopenten-1-one from 5-hydroxymethylfurfural." Green Chemistry 18, no. 10 (2016): 3075–81. http://dx.doi.org/10.1039/c5gc02493e.

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23

AOKI, KAZUO, PAUL E. KIHAILE, JUNICHI MISUMI, WEI PEI, and MASANOBU KUDO. "Reproductive toxicity of 2,5-hexanedione in male rats." Reproductive Medicine and Biology 3, no. 2 (May 20, 2004): 59–62. http://dx.doi.org/10.1111/j.1447-0578.2004.00053.x.

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24

Malorni, Walter, Giuseppe Formisano, and Gianfranco Donelli. "Morphologic changes induced in vitro by 2,5 hexanedione." In Vitro Cellular & Developmental Biology 25, no. 1 (January 1989): 82–90. http://dx.doi.org/10.1007/bf02624415.

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25

Mitolo-Chieppa, D., and M. R. Carratù. "Electrophysiological investigation of 2,5-hexanedione neurotoxicity in rats." Toxicology and Applied Pharmacology 84, no. 2 (June 1986): 250–54. http://dx.doi.org/10.1016/0041-008x(86)90132-8.

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26

Rosenberg, Carlyn K., D. Carter Anthony, Gyöngyi Szakál-Quin, Mary Beth Genter, and Doyle G. Graham. "Hyperbaric oxygen accelerates the neurotoxicity of 2,5-hexanedione." Toxicology and Applied Pharmacology 87, no. 2 (February 1987): 374–79. http://dx.doi.org/10.1016/0041-008x(87)90298-5.

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27

Boekelheide, Kim. "Rat testis during 2,5-hexanedione intoxication and recovery." Toxicology and Applied Pharmacology 92, no. 1 (January 1988): 18–27. http://dx.doi.org/10.1016/0041-008x(88)90223-2.

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28

Boekelheide, Kim. "Rat testis during 2,5-hexanedione intoxication and recovery." Toxicology and Applied Pharmacology 92, no. 1 (January 1988): 28–33. http://dx.doi.org/10.1016/0041-008x(88)90224-4.

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29

Torres, M. E., L. Gonçalves, A. P. Dos Santos, M. C. Batoréu, and M. L. Mateus. "Selection of biomarkers to investigate the protection effect of n-acetylcysteine on 2,5-hexanedione neurotoxicity in rats exposed to 2,5-hexanedione." Toxicology Letters 196 (July 2010): S78. http://dx.doi.org/10.1016/j.toxlet.2010.03.290.

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30

Jortner, B. S., S. Perkins, J. Fox, J. Hinckley, E. Lehning, F. C. Chiu, and R. LoPachin. "NEUROFILAMENTOUS CHANGES IN ATROPHIC AXONS ELICITED BY 2,5-HEXANEDIONE (2,5-HD) IN RATS." Journal of Neuropathology and Experimental Neurology 58, no. 5 (May 1999): 517. http://dx.doi.org/10.1097/00005072-199905000-00043.

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31

Kim, Seong Ah, Sang Jae Jung, Chae Yong Lee, Sang Man Lee, and Sang Woo Kim. "Three Cases of Skin Pigmentation Caused by 2,5-Hexanedione." Korean Journal of Occupational and Environmental Medicine 14, no. 2 (2002): 199. http://dx.doi.org/10.35371/kjoem.2002.14.2.199.

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32

STERMAN, A. B., and N. SPOSITO. "2,5-HEXANEDIONE AND ACRYLAMIDE PRODUCE REORGANIZATION OF MOTONEURON PERIKARYA." Neuropathology and Applied Neurobiology 11, no. 3 (May 1985): 201–12. http://dx.doi.org/10.1111/j.1365-2990.1985.tb00018.x.

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33

Ahonen, I., and R. W. Schimberg. "2,5-Hexanedione excretion after occupational exposure to n-hexane." Occupational and Environmental Medicine 45, no. 2 (February 1, 1988): 133–36. http://dx.doi.org/10.1136/oem.45.2.133.

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34

Perbellini, L., D. M. Marhuenda Amoros, A. C. Cardona Llorens, C. Giuliari, and F. Brugnone. "An improved method of analysing 2,5-hexanedione in urine." Occupational and Environmental Medicine 47, no. 6 (June 1, 1990): 421–24. http://dx.doi.org/10.1136/oem.47.6.421.

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35

Pereira, M. E., J. B. T. Rocha, and I. Izquierdo. "Atropine Reverses Antinociception Induced by 2,5-Hexanedione in Rats." Pharmacology & Toxicology 77, no. 2 (August 1995): 91–94. http://dx.doi.org/10.1111/j.1600-0773.1995.tb00995.x.

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36

Pereira, Maria E., Andréa I. H. Adams, and Nélson S. Silva. "2,5-Hexanedione inhibits rat brain acetylcholinesterase activity in vitro." Toxicology Letters 146, no. 3 (February 2004): 269–74. http://dx.doi.org/10.1016/j.toxlet.2003.10.009.

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37

Sturaro, A., G. Parvoli, and L. Doretti. "High-performance liquid chromatographic determination of urinary 2,5-hexanedione." Journal of Chromatography A 628, no. 2 (January 1993): 316–18. http://dx.doi.org/10.1016/0021-9673(93)80014-y.

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38

Hammond-Tooke, Graeme David. "Slow axonal transport is impaired by intrathecal 2,5-hexanedione." Experimental Neurology 116, no. 2 (May 1992): 210–17. http://dx.doi.org/10.1016/0014-4886(92)90170-u.

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39

Yu, Rong, Dale Hattis, Elliot M. Landaw, and John R. Froines. "Toxicokinetic interaction of 2,5-hexanedione and methyl ethyl ketone." Archives of Toxicology 75, no. 11-12 (December 15, 2001): 643–52. http://dx.doi.org/10.1007/s00204-001-0298-2.

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40

Ogawa, Yasutaka, Hidesuke Shimizu, and Seung U. Kim. "2,5-hexanedione induced apoptosis in cultured mouse DRG neurons." International Archives of Occupational and Environmental Health 68, no. 6 (September 1996): 495–97. http://dx.doi.org/10.1007/bf00377875.

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41

Gold, Bruce G., and John W. Griffin. "PROXIMAL AXONAL SWELLINGS PRODUCED BY ACUTE 2,5-HEXANEDIONE ADMINISTRATION." Journal of Neuropathology and Experimental Neurology 44, no. 3 (May 1985): 349. http://dx.doi.org/10.1097/00005072-198505000-00134.

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42

Ogawa, Y., Hidesuke Shimizu, and Seung U. Kim. "2,5-Hexanedione induced apoptosis in cultured mouse DRG neurons." International Archives of Occupational and Environmental Health 68, no. 6 (September 1, 1996): 495–97. http://dx.doi.org/10.1007/s004200050099.

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43

Governa, Mario, Matted Valentino, Isa Visona', and Marsilia Rocco. "Impairment of human polymorphonuclear leukocyte chemotaxis by 2,5-hexanedione." Cell Biology and Toxicology 2, no. 1 (March 1986): 33–39. http://dx.doi.org/10.1007/bf00117705.

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44

Wang, Longjuan, Shuang Liu, Dan Su, Feng Chen, Tengteng Lei, Haibo Chen, Wei Dong, Yue Jiang, Xiance Sun, and Wenchang Sun. "2,5-Hexanedione increases the percentage of proliferative Sox2+ cells in rat hippocampus." Toxicology and Industrial Health 34, no. 9 (May 15, 2018): 589–95. http://dx.doi.org/10.1177/0748233718772767.

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n-Hexane is an organic solvent widely used in industry. 2,5-Hexanedione (2,5-HD), the major neurotoxic metabolite of n-hexane, decreases the levels of neurofilaments (NFs) in neurons. Neurogenesis occurs throughout life, and the hippocampal dentate gyrus is one of two major brain areas showing neurogenesis in adulthood. In the current study, rats were intraperitoneally injected with normal saline solution or 2,5-HD five times per week for five continuous weeks. 2,5-HD was administered to the low-dose and high-dose groups at 200 and 400 mg/kg/day, respectively. Then, immunoreactive cells were counted in the hippocampal granule cell layer (GCL) and subgranular zone (SGZ). Ki67+ cells significantly decreased in the high-dose group, while the percentage of proliferative Sox2+ cells significantly increased, consistent with high hippocampal Sox2 expression. Additionally, western blotting showed that exposure to high doses of 2,5-HD led to decreased NF-L in both the cortex and hippocampus, whereas low doses led to a significant reduction in the cortex only. In conclusion, 2,5-HD increases the percentage of proliferating neural stem and progenitor (Sox2+) cells in the SGZ/GCL.
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45

Adedara, Isaac A., Amos O. Abolaji, Blessing E. Odion, Isioma J. Okwudi, Abiola A. Omoloja, and Ebenezer O. Farombi. "Impairment of Hepatic and Renal Functions by 2,5-Hexanedione Is Accompanied by Oxidative Stress in Rats." Journal of Toxicology 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/239240.

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2,5-Hexanedione (2,5-HD) is the toxic metabolite of n-hexane which is widely used as solvent in numerous industries. The present study elucidated the precise mechanism of 2,5-HD in hepatorenal toxicity by determining the involvement of oxidative stress in rats. Adult male Wistar rats were exposed to 0, 0.25, 0.5, and 1% 2,5-HD in drinking water for 21 days. Exposure to 2,5-HD caused liver and kidney atrophy evidenced by significant elevation in serum aminotransferases, alkaline phosphatase, albumin, bilirubin, urea, creatinine, and electrolytes levels compared with control. The marked dose-dependent increase in total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL) was accompanied with significant decrease in high-density lipoprotein (HDL) levels in 2,5-HD-exposed animals when compared with the control. Administration of 2,5-HD significantly diminished glutathione (GSH) level but increased the activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), and glutathione-S-transferase (GST) concomitantly with marked elevation in hydrogen peroxide (H2O2) and malondialdehyde (MDA) levels in liver and kidney of the treated groups compared with control. These findings suggest that undue exposure to 2,5-HD at environmentally relevant levels may impair liver and kidney functions through induction of oxidative stress.
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46

Wang, Ran, Yanting Liu, Guangyi Li, Aiqin Wang, Xiaodong Wang, Yu Cong, Tao Zhang, and Ning Li. "Direct Synthesis of Methylcyclopentadiene with 2,5-Hexanedione over Zinc Molybdates." ACS Catalysis 11, no. 8 (April 5, 2021): 4810–20. http://dx.doi.org/10.1021/acscatal.1c00223.

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47

Mayan, Olga, Joao Paulo Teixeira, Sandra Alves, and Conceição Azevedo. "Urinary 2,5 hexanedione as a biomarker of n-hexane exposure." Biomarkers 7, no. 4 (January 2002): 299–305. http://dx.doi.org/10.1080/13547500210136796.

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48

Bavazzano, Paolo, Paolo Apostoli, Claudio Balducci, Giovanni Battista Bartolucci, Marina Buratti, Piergiorgio Duca, Giampaolo Gori, et al. "Determination of urinary 2,5-hexanedione in the general Italian population." International Archives of Occupational and Environmental Health 71, no. 4 (May 12, 1998): 284–88. http://dx.doi.org/10.1007/s004200050282.

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49

Hirata, Mamoru. "Reduced conduction function in central nervous system by 2,5-hexanedione." Neurotoxicology and Teratology 12, no. 6 (November 1990): 623–26. http://dx.doi.org/10.1016/0892-0362(90)90074-m.

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50

Lapadula, Daniel M., Elizabeth Suwita, and Mohamed B. Abou-Donia. "Evidence for multiple mechanisms responsible for 2,5-hexanedione-induced neuropathy." Brain Research 458, no. 1 (August 1988): 123–31. http://dx.doi.org/10.1016/0006-8993(88)90503-3.

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