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Nfor, Nformi Emmanuel. "Sequence stratigraphic characterisation of petroleum reservoirs in Block 11b/12b of the Southern Outeniqua Basin." University of the Western Cape, 2011. http://hdl.handle.net/11394/2924.
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Magister Scientiae - MScThe main purpose of this study was to identify and characterize the various sand prone depositional facies in the deepwater Southern Outeniqua Basin which generally tend to form during lowstand (marine regression) conditions producing progradational facies. It made use of sequence stratigraphy and turbidite facies models to predict the probable location of deepwater reservoirs in the undrilled Southern Outeniqua Basin using data from basin margin Pletmos Basin and the deepwater Southern Outeniqua Basin. Basin margin depositional packages were correlated in time and space with deepwater packages. It was an attempt at bridging the gap between process-related studies of sedimentary rocks and the more traditional economic geology f commercial deposits of petroleum using prevailing state-of-the-art in basin analysis. It enabled the most realistic reconstructions of genetic stratigraphy and offered the greatest application in exploration. Sequence stratigraphic analysis and interpretation of seismics, well logs, cores and biostratigraphic data was carried out providing a chronostratigraphic framework of the study area within which seismic facies analysis done. Nine (9) seismic lines that span the shallow/basin margin Pletmos basin into the undrilled deepwater Southern Outeniqua basin were analysed and interpreted and the relevant seismic geometries were captured. Four (4) turbidite depositional elements were identified from the seismic lines: channel, overbank deposits, haotic deposits and basin plain (basin floor fan) deposits. These were identified from the relevant seismic geometries (geometric attributes) observed on the 2D seismic lines. Thinning attributes, unconformity attributes and seismic facies attributes were observed from the seismic lines. This was preceded by basic structural analyses and interpretation of the seismic lines. according to the structural analysis and interpretation, deposition trended NW-SE and NNW-SSE as we go deepwater into the Southern Outeniqua basin. Well logs from six (6) of the interpreted wells indicated depositional channel fill as well as basin floor fans. This was identified in well Ga-V1 and Ga-S1 respectively. A bell and crescent shape gamma ray log signature was observed in well Ga-V1 indicating a fining up sequence as the channel was abandoned while an isolated massive mound-shape gamma ray log signature was observed in Ga-S1 indicating basin plain well-sorted sands. Core analyses and interpretation from two southern-most wells revealed three (3) facies which were derived based on Walker‘s 1978, turbidite facies. The observed facies were: sandstone, sand/shale and shale facies. Sequence stratigraphic characterisation of petroleum reservoirs in block 11b/12b of the Southern Outeniqua Basin. Cores of well Ga-V1 displayed fine-grained alternations of thin sandstone beds and shales belonging to the thin-bedded turbidite facies. This is typical of levees of the upper fan channel but could easily be confused with similar facies on the basin plain. According to Walker, 1978 such facies form under conditions of active fan progradation. Ga-S1 cores displayed not only classic turbidite facies where there was alternating sand and shale sections but showed thick uninterrupted sections of clean sands. This is typical of basin plain deposits. Only one well had biostratigraphic data though being very limited in content. This data revealed particular depth sections and stratigraphic sections as having medium to fast depositional rates. Such rates are characteristic of turbidite deposition from turbidity currents. This study as well as a complementary study by Carvajal et al., 2009 revealed that the Southern Outeniqua basin is a sand-prone basin with many progradational sequences in which tectonics and sediment supply rate have been significant factors (amongst others such as sea level change) in the formation of these deepwater sequences. In conclusion, the Southern Outeniqua basin was hereby seen as having a viable and unexplored petroleum system existing in this sand prone untested world class.
South Africa
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Surdej, Patrick. "L' organisation strucrurale et fonctionnelle de la région 14B-15B du chromosome X de Drosophila melanogaster." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX22055.
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Clonage d'un brin d'adn de 800 kb du chromosome x de la drosophile (15b-15b). Organisation des regions transcrites et profil d'expression au cours du developpement, caracterisation de regions d'attachement a la matrice nucleaire
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Brun, Christine. "Organisation en boucles de la molécule d'ADN et réplication : tude de la région 14B-15B du chromosome X et de l'unité des gènes ribosomiques de Drosophila melanogaster." Aix-Marseille 2, 1992. http://www.theses.fr/1992AIX22017.
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La molecule d'adn, constitutive du chromosome eucaryote, est organisee en boucles dont les bases sont ancrees dans un reseau proteique interne nomme scaffold. L'implication des sites d'attachement de la molecule d'adn au scaffold (=sar) dans les mecanismes de replication a ete etudiee dans deux regions distinctes du genome de la drosophile: la region 14b-15b du chromosome x, mesurant 800 kb, qui a ete clonee dans le laboratoire et dont l'organisation en boucles a ete determinee lors d'une etude anterieure, et l'unite des genes codant pour les arns ribosomiques. Dans une premiere etape, l'activite de replication autonome (=ars) de fragments de restriction representatifs de la region 14b-15b a ete testee par transformation heterologue de levure. 27 fragments manifestent une activite ars. 25 d'entre eux sont des sars. Il existe donc une correlation entre les deux types d'activites: une sous-classe de sars de drosophile est impliquee dans les mecanismes de replication extrachromosomique chez la levure. De plus, l'association au scaffold est conservee entre les deux especes: lors d'un test de re-association in vitro, 61% des sars testes sont capables de s'associer a des scaffolds de levure. Dans une deuxieme etape, l'existence d'une relation entre sites d'attachement, sequences ars dans la levure et origines de replication chromosomiques a ete abordee. Pour cela, l'organisation en boucles de l'unite repetee des genes ribosomiques a ete determinee. Trois sars ont ete identifies a l'interieur des trois espaceurs presents dans l'unite. Ils definissent trois boucles d'adn contenant la region codant pour l'arn 18s, une partie de la region codant pour l'arn 28s et une region entourant le site +1 de transcription, respectivement. Ces 3 sars de drosophile sont egalement capables de s'associer a des scaffolds de levure. Trois regions de l'unite sont impliquees dans les mecanismes de replication extrachromosomique chez la levure. Elles correspondent aux regions en interaction avec le scaffold. De plus, la technique d'electrophorese bidimensionnelle neutre/neutre a permis de localiser une origine de replication chromosomique dans un fragment d'adn couvrant deux des espaceurs. Ces resultats montrent donc qu'au moins dans un cas, une proximite topologique existe entre des sequences impliquees dans l'association de la molecule d'adn au scaffold, dans la replication extrachromosomique chez la levure et dans l'initiation de la replication chromosomique. Cela suggere une relation fonctionnelle etroite entre ces trois types de sequences
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Lau, Peggy. "The role of 4-1BB/4-1BB ligand costimulation in T cell responses." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58825.pdf.
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Frerichs, Stefan, Karl Hamacher, and André Simon. "Sündenfall § 13b BauGB? Eine Bestandsaufnahme." Rhombos-Verlag, 2020. https://slub.qucosa.de/id/qucosa%3A76161.
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Zwei Jahre nach Einführung des § 13b BauGB sind bundesweit bereits zahlreiche Anwendungsfälle bekannt. Sie zeigen, dass sich die Erwartungen an die Einführung der Regelung, auf Kosten von materiellen und Verfahrensstandards schnell und in substantiellem Umfang Wohnbauland zur Minderung der Wohnungsnot zu schaffen, nicht erfüllt haben. Einwohnerstarke Städte mit hohem Wohnraumbedarf und angespannten Wohnungsmärkten wenden die neuen Regelungen nicht an. Die Nutzung des § 13b BauGB erfolgt in kleineren und kleinsten Gemeinden, häufig ohne besonderen Wohnraumbedarf, zur Ausweisung von Ein- und Zweifamilienhausgebieten. In vielen Fällen lässt sich feststellen, dass die Flächeninanspruchnahme für Siedlungszwecke unnötig verstärkt wird und viele dieser Gemeinden Wohnbaulandflächen auf Vorrat ausweisen, die mit Blick auf die Bevölkerungsentwicklung voraussichtlich nicht notwendig sein werden. Damit einher geht eine unnötige Belastung von Umwelt und Natur einerseits und Entwertung des innerörtlichen Baubestandes andererseits.
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Ralston, James. "The 10B(n, α) and 10B(n, p) Cross-Sections in the MeV Energy Range." Ohio University Honors Tutorial College / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1315160730.
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Roberto, Gabriela Molinari. "Influência do miR-10b na proliferação e capacidade invasiva de osteossarcoma." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17154/tde-12042018-120108/.
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O Osteossarcoma (OS) é o tumor ósseo pediátrico mais comum. O tratamento atual consiste em remoção cirúrgica e quimioterapia multimodal neo- e adjuvante. No entanto, um terço dos pacientes são acometidos por recorrência pós-cirúrgica e metástases distantes sendo que apenas 20% daqueles com metástase sobrevivem após 5 anos. Diversos miRNAs vêm sendo apontados como metastamiRs, dentre eles o miR-10b. Este microRNA encontra-se hiperexpresso em uma série de tumores e associado a pior prognóstico. Estudos prévios têm demostrado que o miR-10b atua nos processos invasivos principalmente pareando-se de forma incompleta com o RNA mensageiro do gene HOXD10 e assim inibindo a sua tradução. Este fator de transcrição, assim como todos os membros da família dos genes HOX, exerce sua função ativando e reprimindo genes vitais para os processos de crescimento e diferenciação celular (inclusive durante o desenvolvimento do tecido ósseo), sendo também descrito como desregulado em diversos tumores. Em vista disso, o presente trabalho teve como objetivo estudar a influência do miR-10b no OS e sua associação com o gene HOXD10 em relação aos processos de proliferação, invasão e migração celular. Para tanto, foi avaliada a expressão de ambos em amostras tumorais, bem como os efeitos da modulação da expressão de miR-10b na capacidade proliferativa e invasiva de linhagens celulares de OS. Nossos resultados mostraram uma associação inversa entre os níveis de expressão do miR-10b e o grau de malignidade. O aumento de miR-10b in vitro levou a supressão da capacidade clonogênica e à redução dos processos de adesão, migração e invasão, sugerindo um papel de supressor tumoral em OS. Não foi encontrada correlação entre a expressão gênica do miR-10b e a do HOXD10, e ainda o aumento deste microRNA não alterou a expressão proteica do fator de transcrição. Sendo assim, o mecanismo pelo qual miR-10b contribui para a agressividade do OS permanece indefinido, mas parece ser independente de HOXD10. Paralelamente, a expressão do gene KLF4 (recentemente descrito como alvo direto de miR-10b) e de genes sabidamente associados à invasão (MMP2 e ROCK1) e proliferação (TP53 e BCL2) tampouco foi afetada após transfecção. Por outro lado, apesar de não ter sido confirmado como alvo de miR-10b no nosso estudo, HOXD10 foi encontrado significativamente hiperexpresso nas amostras de OS. Assim, considerando a importância da desregulação de vias de desenvolvimento no surgimento de tumores pediátricos e a participação do HOXD10 no desenvolvimento ósseo, o seu papel como oncogene e seu potencial como alvo terapêutico neste tipo tumoral merecem estudos posteriores.Osteosarcoma (OS) is the most common pediatric bone tumor. The current treatment consists of surgical removal and neo- and adjuvant multimodal chemotherapy. Nonetheless, one-third of patients are affected by post-surgical recurrence and distant metastases, with only 20% of metastatic cases surviving after 5 years. Several miRNAs have been designated as metastamiRs, among them miR-10b. This microRNA is overexpressed in a series of tumors and associated with poor prognosis. Previous studies have shown that miR-10b acts on invasive processes mainly by pairing with the messenger RNA of the HOXD10 and thereby inhibiting its translation. This transcription factor, like all members of the HOX family, exerts its function by activating and/or repressing vital genes for cell growth and differentiation (even during the development of bone tissue) and is also described as deregulated in several tumors. In view of this, the aim of this work was to study the influence of miR-10b on OS and its association with the HOXD10 in relation to proliferation, invasion and cell migration. For this, the expression of both genes in tumor samples, as well as the effects of miR-10b expression modulation on the proliferative and invasive capacity of OS cell lines, were evaluated. Our results showed an inverse association between miR-10b expression levels and the degree of malignancy. The increase of miR-10b in vitro led to the suppression of clonogenic capacity and reduction of adhesion, migration and invasion, suggesting a role as a tumor suppressor in OS. No correlation was found between the gene expression of miR-10b and HOXD10, while the increase of the microRNA did not alter the protein levels of the transcription factor. Thus, the mechanism by which miR- 10b could contribute to OS aggressiveness remains undefined, though it appears to be independent of HOXD10. In parallel, the expression of KLF4 (recently described as a direct miR-10b target) and of genes known to be associated with invasion (MMP2 and ROCK1) and proliferation (TP53 and BCL2) was not affected after transfection. On the other hand, although HOXD10 was not confirmed as a miR-10b target in our study, this gene was found to be significantly overexpressed in the OS samples. Thus, considering the importance of the deregulation of developmental pathways on pediatric tumors and HOXD10 contribution on bone development, its role as an oncogene and its potential as a therapeutic target in this tumor type deserves further studies.
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Ferreira, Andre Vargas. "Síntese de aminoácidos não-proteinogênicos enriquecidos em 10B utilizados na Terapia de Captura de Nêutrons por Boro (BNCT)." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/64/64135/tde-03092013-160315/.
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O Glioblastoma Multiforme (GMB), tipo de câncer cerebral mais comum e agressivo, apesar dos recentes avanços na pesquisa em neurociência, é muitas vezes incurável e com prognóstico obscuro. Diante da resistência e da inespecificidade dos tratamentos frente a esses tumores, o maior desafio atualmente está no desenvolvimento de estratégias moleculares mais específicas às células cancerígenas e menos agressivas aos pacientes. A terapia de captura de nêutrons por boro, comumente conhecida como BNCT (do inglês Boron Neutron Capture Therapy) fornece um caminho de destruição seletiva das células tumorais poupando as normais, sendo esta terapia baseada na reação de fissão nuclear entre o 10B, um dos isótopos estáveis de boro, e nêutrons de baixa energia. Destaca-se a utilização de isótopos estáveis na área biomédica pelo fato destes serem inócuos ao organismo dos pacientes e não possuírem limite de dosagem. Desta forma, o objetivo do presente trabalho consiste na síntese do principal fármaco utilizado na BNCT, o L-4-borofenilalanina enriquecido em 10B. Para isso, utilizou-se da reação de Morita-Baylis-Hillman (MBH) cuja definição geral é uma condensação entre carbonos eletrofílicos sp2 e a posição \'alfa\' de uma olefina com grupos retiradores de elétrons ativada por uma amina terciária ou uma fosfina, gerando uma nova ligação \'sigma\'C-C. Essa reação apresenta algumas vantagens que evidenciam as reações de MBH como uma metodologia sintética eficiente: são regio e quimioseletivas; possuem uma elevada economia de átomos, necessitam condições brandas de trabalho fornecendo. Estabeleceu-se metodologia para a síntese do 4-bromofenilalanina, precursor do fármaco L-4-borofenilalanina por meio de duas abordagens sintéticas inéditas e distintas. A ampliação do escopo dessa sequência de reações para sintetizar outros aminoácidos não-proteinogênicos demonstra a robustez da nova rota sintética abrindo a possibilidade de síntese de outros aminoácidos enriquecidos em isótopos estáveis de elementos leves com aplicação biomédica. A primeira abordagem sintética compreendeu 6 etapas e foi possível obter um rendimento global de 24%. A segunda abordagem sintética foi realizada em 4 etapas possibilitando obter o mesmo aminoácido com rendimento global de 46%Glioblastoma Multiforme (GMB), a most common and aggressive type of brain cancer, in spite of recent advances in neuroscience research, is often incurable and the prognosis is obscure. In front of the resistance and specificity of the treatments against these tumors, the biggest challenge nowadays is to develop molecular strategies more specific to tumor cells and less aggressive for the patient. Boron Neutron Capture Therapy (BNCT) provides a path of selective destruction of tumor cells sparing the normal ones, which this therapy based on nuclear fission reaction between 10B, one of the stable isotopes of boron and low-energy neutrons. Emphasizes the use of stable isotopes in the biomedical area because these are innocuous to the body of the patients and do not have limit dosage. Thus, the aim of this master is the synthesis of the main drug used in BNCT, the L-4-boronophenylalanine enriched in 10B. For this, we used the Morita-Baylis-Hillman (MBH) which definition is a condensation between sp2 eletrophilic carbon and the position \'alfa\' of an olefin activated by tertiary amine or phosphine, generating a new \'sigma\'C-C bond. This reaction has some advantages that evidence the reactions of MBH as an efficient synthetic methodology: are regio and quimioselective, have high atom economy, require mild conditions providing polifunctionalized molecules that through small changes in chemical structure can generate a series of synthetic intermediates, pharmaceuticals, etc. It was established methodology for the synthesis of 4-bromophenylalanine, drug precursor of L-4-boronophenylalanine through two distinct and previously unreleased synthetic approaches. The expansion of the scope of this sequence of reactions to synthesize other non-proteinogenic amino acids demonstrates the robustness of the new synthetic route opening up the possibility of synthesis of other amino acids enriched in stable isotopes with biomedical application. The first approach consisted 6 steps and it was possible to obtain an overall yield of 24%. The second approach was performed in 4 synthetic steps obtaining the same amino acid with an overall yield of 34.77%
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Stenz, Oliver [Verfasser]. "§ 15b EStG – Verlustverrechnungsbeschränkungen bei Steuerstundungsmodellen / Oliver Stenz." Aachen : Shaker, 2010. http://d-nb.info/1081885467/34.
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Neumann-Cosel, Matthias Sigurd v. "Die Reichweite des Insiderverzeichnisses nach 15b WpHG /." Frankfurt, M. [u.a.] : Lang, 2008. http://d-nb.info/98852046X/04.
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Boaretto, Rodrigo Marcelli. "Boro(10B) em laranjeira: absorção e mobilidade." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/64/64132/tde-28032006-155450/.
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A deficiência de boro (B) é comum nos pomares citrícolas paulistas. A maioria das pesquisas sobre mobilidade (transporte e redistribuição) de micronutrientes têm sido realizadas com o auxílio de isótopos radioativos, entretanto, para o B não existe um isótopo radioativo com meia vida suficientemente longa para tais estudos. Os isótopos estáveis de B (10B e 11B) foram pouco utilizados como traçador em estudos com vegetais, devido à dificuldade de detecção, entretanto, com o advento do ICP-MS (inductively coupled plasma mass spectrometry espectrômetro de massas acoplado a uma fonte de plasma),tornou-se possível quantificar os átomos de 10B e 11B. Desta forma, utilizando-se de compostos enriquecidos em 10B, tornaram-se viáveis os estudos de absorção, transporte e redistribuição do B nas plantas. O objetivo do presente trabalho foi estudar, com o auxilio da técnica isotópica, a absorção de B pelas raízes e folhas da laranjeira, verificar a mobilidade do elemento na planta e quantificar a contribuição da adubação com B para os frutos da laranjeira. No estudo foram realizados 4 experimentos, sendo 3 experimentos realizados em casa de vegetação e 1 experimento realizado em pomar de laranjeira em produção. Dos experimentos realizados em casa de vegetação, O primeiro estudou a absorção de B pelas raízes de laranjeiras em sistema hidropônico e a mobilidade do nutriente na planta. Laranjeiras de copa Valencia em dois porta-enxertos (limoeiro Cravo e citrumelo Swingle) foram conduzidas em soluções nutritivas com concentrações de B adequadas ou deficientes, e o início dos tratamentos com 10B ocorreram em épocas distintas, com plantas em diferentes condições nutricionais de B. O segundo experimento estudou a eficiência da absorção foliar de B pelas laranjeiras ao longo do tempo e a mobilidade do nutriente na planta. O terceiro experimento comparou a mobilidade do B, absorvido pelas raízes e pelas folhas, para os novos fluxos de crescimento. O quarto experimento, realizado no campo, comparou as adubações com B no solo, via fertirrigação, e nas folhas das laranjeiras. Avaliou a contribuição destas adubações para os frutos das laranjeiras e verificou o efeito residual da adubação realizada no ano anterior na nutrição da planta no ano seguinte. Pelos resultados obtidos nos experimentos foi possível verificar que cerca de 20% a 40% do B presente nas partes novas da laranjeira foi proveniente de reservas das laranjeiras, ou seja, foi redistribuído na planta, e o menor valor foi obtido quando as laranjeiras estavam deficientes em B. A absorção de B pelas folhas da laranjeira foi inferior a 9% total de B depositado nas folhas, e o nutriente permaneceu principalmente nos órgãos onde foi aplicado (97%). A adubação com B no solo foi, cerca de 3 a 4 vezes, mais eficiente em fornecer o nutriente para a laranjeira, do que a aplicação do nutriente na folha.Boron deficiency is widespread in São Paulo citrus orchards. Most of researches on micronutrients mobility (transport and redistribution) have been carried out using radioactive isotopes, however, for the B there is not any radioactive isotope with half-life enough for such studies. The B stable isotopes (10B and 11B) had little been used as tracer in plant studies due to the difficult detection, but with the development of the ICP-MS inductively coupled plasma mass spectrometry), it is possible to quantify the atoms of 10B and 11B. This way, using enriched compound with 10B, the absorption, transport and redistribution studies have become possible.The present work aimed to study, with aid of isotopic methodology, the B absorption through the roots and leaf of orange plant, to verify the B mobility in the plant and to quantify the B fertilization contribution to the fruit. In the study 4 experiments were carried out, 3 experiments in greenhouse and 1 experiment in a productive orange orchard. From the experiment carried out in greenhouse, in the first one the B absorption through the roots in nutrient solution system and the nutrient mobility in the plant were studied. Valencia sweet orange trees budded on Rangpur lime or Swingle citrumelo were grown in nutrient solution with suitable or deficient B supply, and the treatments with 10B were initiated in different periods with plants in different nutritional condition of B. The second experiment studied the efficiency of B uptake by the orange leaves, which were harvested in different periods after 10B spraying, and the nutrient mobility in the plant. The third experiment compared the B mobility absorbed through roots and leaves, and driven to the new shoots. The fourth experiment, performed in orange orchard, compared the B applied in the soil by fertigation and in the leaves. The contribution of B from fertilizer to the fruits was evaluated and verified the residual effect of fertilizer applied in the year before on the plant nourishing in the next year. By the results from the experiments it was possible to verify that approximately 20% to 40% of B contained in the new parts of orange plant was derivated from old parts, in other words, the B was redistributed in the plant, and the lower value was obtained when the plants grew in nutrient solution with deficient B supply. The B absorption by the leaves was less than 9% of total B deposited on the foliar lamina, and remained mainly in the sites where it was applied (97%). The B fertilization in the soil was, approximately 3 to 4 times more efficient in providing B to the orange plant than the B sprayed on the leaves.
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Gongol, Jakub. "Návrh malého proudového motoru do 1kN tahu." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2013. http://www.nusl.cz/ntk/nusl-230963.
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This work will be focused on issue of a jet engine. The thesis will be divided into search retrieval part and computational part. In the search retrieval part it will focus on different configurations of jet engines as well as areas of their use. The main part of the thesis will however focus on a calculations where a turbine, compressor and an exhaust nozzle will be designed in order to give a thrust of approximately 1kN. Next step will be determination of an engine charcteristic that will give us a preview on how the engine performance will look like in off-design modes.
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Mabuda, Azwihangwisi Iren. "The determination of boron using 11B(p, α)8Be nuclear reaction." Thesis, UWC, 2008. http://hdl.handle.net/11394/2872.
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>Magister Scientiae - MScDetermination of trace quantities of boron is required in various studies of materials and in geology. Using 11B(p, α)8Be nuclear reaction with focused proton beam of 670 keV energy is one of the few microanalytical techniques capable of achieving detection limits in the 5-10 ppm range. The set-up for the determination of boron with high sensitivity was developed at iThemba LABS nuclear microprobe (NMP) facility by using a PIN photodiodes detector. The trace elements such as boron and lithium were analyzed using the nuclear reaction analysis (NRA) method. This project aims at performing microanalysis of boron by NRA method and reaching the developmental phase in which routine, non-destructive boron analyses would be possible at detection limits below 5 ppm. A 228Th source was used for energy calibration of the detector. Five set of standards and unknown samples with a wide range of boron concentrations were analyzed in order to demonstrate the effectiveness of the 11B(p, α)8Be reaction by NRA technique. The standards were used to calibrate the boron yield with respect to their concentration in order to determine the boron concentration of the unknown specimen from the calibrated curve. The determination of the detection limit was also addressed. The concentrations of boron from Mts+Tu 950 glass samples were ranging between 0.17-1.05 wt % and the detection limit of 8.6 ppm for the minimum counts of 100 for 1μC accumulated charge was obtained.
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Moseley, Timothy Alexander. "Identification and characterization of interleukin-17B in cartilage /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2005. http://uclibs.org/PID/11984.
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Lecouey, Jean-Luc. "Etude des systèmes non liés 16B et 13Be." Phd thesis, Université de Caen, 2002. http://tel.archives-ouvertes.fr/tel-00003117.
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Ce travail porte sur l'étude de deux systèmes non liés, le 16B et le 13Be, dont la structure très exotique fournit de fortes contraintes sur les modèles actuels et des informations primordiales pour modéliser les systèmes à trois corps que sont les noyaux à halo borroméens 17B et 14Be. Les deux expériences réalisées au GANIL consistaient à peupler les noyaux d'intérêt à partir de réactions de perte d'un proton d'un faisceau secondaire de 17C à 35 MeV/nucléon pour le 16B et de 14B à 41 MeV/nucléon pour le 13Be. L'utilisation d'un télescope sensible en position Si-Si-CsI de la collaboration CHARISSA pour détecter les fragments chargés, et du multidétecteur DéMoN pour les neutrons, permettait de reconstruire les spectres en énergie de décroissance du 16B et du 13Be à partir des coïncidences 15B-n et 12Be-n. Une description théorique, fondée sur l'approximation soudaine, du peuplement des états finals non liés a été développée. Les spectres en énergie de décroissance prédits ont été comparés aux données après convolution avec la réponse du dispositif expérimental, obtenue en utilisant deux codes de simulation, le premier basé sur GEANT et le second, BELZEBUTH, développé spécialement pour cette étude. Le meilleur accord avec les données 15B+n suppose le peuplement d'une (de) résonance(s) d très étroites à basse énergie (environ 85 keV). Les données 12Be+n sont en accord avec le peuplement d'un état s très large (1-2 MeV) autour de 600-800 keV et d'une résonance d à 2,5 MeV.
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Júnior, Francisco Carneiro. "Enriquecimento de 10B por cromatografia de troca aniônica." Universidade de São Paulo, 1989. http://teses.usp.br/teses/disponiveis/11/11133/tde-20181127-155856/.
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A separação dos isótopos do boro foi efetuada através da reação de troca isotópica entre o ácido bórico em solução aquosa e os ânions boratos e poliboratos adsorvidos em resinas de troca aniônica do tipo amônio (Dowex 1 e 2), em colunas de vidro de 100 cm de comprimento por 1,4 cm de diâmetro. Foram feitos estudos da variação do fator de fracionamento, medido por análise frontal, em função da concentração do ácido bórico em solução. Foram também conduzidos sobre o fracionamento de 10B e 11 B utilizando-se da técnica cromatográfica de deslocamento por desenvolvimento. As determinações da composição isotópica do boro se realizaram com um espectrômetro de massas"Atlas Varian"modelo CH-4, utilizando-se do gás borato de metila, obtido por reação direta do ácido bórico da amostra correspondente com metanol, em linha de vácuoThe separation of boron isotopes was carried out through isotopic exchange reaction between boric acid in solution and borate and poliborate anions adsorved on an ammonium quaternary (Dowex 1 and 2) anion exchange resin packed in a glass column, 100 cm lenght and 1.4 cm in diameter. Isotope fractionation factors were calculated through the analysis of break through curves as a function of boric acid concentration in solution 10B and 11B fractionation factors for the column were also studied using chromatographic displacement techniques. Boron isotopic concentration analysis were performed in an"Atlas Varian"CH-4 model mass-spectrometer. Methyl borate gas, obtained through direct reaction between boric acid and methanol in a vacuum line, was used for the analysis
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Carron, Christophe. "Onduleur 1kW pour roue à eau à vitesse variable /." Sion, 2006. http://doc.rero.ch/search.py?recid=8392&ln=fr.
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Silva, Sylvia Leticia Oliveira. "Absorção e mobilidade floemática de boro (10B) em caupi /." Jaboticabal, 2016. http://hdl.handle.net/11449/144619.
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Orientador: Renato de Mello PradoCoorientador: Cassio Hamilton Abreu Júnior
Banca: Fábio Olivieri de Nobile
Banca: Aguinaldo José Freitas Leal
Banca: Priscila Lupino Gratão
Banca: Mara Cristina Pessôa da Cruz
Resumo: A deficiência de boro pode afetar a eficiência nutricional e o crescimento vegetativo e reprodutivo, induzindo alterações celulares no feijão-caupi. A eficiência do fornecimento do B via foliar, na cultura pode depender da concentração adequada do micronutriente na calda de pulverização, e se associado ao sorbitol poderia potencializar a sua absorção e crescimento. Propôs-se avaliar os efeitos da deficiência de boro na planta e da adubação foliar com boro na ausência e na presença de sorbitol no crescimento e no acúmulo de boro na planta, na produção e sua mobilidade no feijão-caupi. No estudo foram realizados três ensaios no período de fevereiro/ 2014 a maio/2015. No experimento I, empregaram-se dois tratamentos com solução nutritiva sob ausência (-B) e presença de boro (+B) em dez repetições. No experimento II utilizou-se esquema fatorial 5x2, sendo cinco concentrações de B (0; 1,25; 2,5; 3,75 e 5,0 g L-1 de B), via foliar, na forma de ácido bórico, na ausência ou na presença de sorbitol (500 mmol L 1), com quatro repetições. No experimento III estudou-se a mobilidade do boro marcado (10B) absorvido pelas raízes e pelas folhas. Avaliaram-se os sintomas de deficiência de boro, o crescimento da raiz, a massa seca dos órgãos da planta e o teor de B e a produção de grãos. A deficiência de boro em plantas de feijão-caupi diminuiu a eficiência de absorção de B, embora tenha aumentado à eficiência de uso do nutriente, mas os maiores prejuízos ocorreram nas variáveis reprodutivas e... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Boron deficiency can affect nutritional efficiency, as well as vegetative and reproductive growth, inducing cell changes in cowpea. Efficiency of B supply via foliar application in crops may depend on its proper concentration in spray solution, and when associated with sorbitol, it could enhance its absorption and plant growth. The aim of this study was to assess the effects of boron deficiency and foliar fertilization in the absence and presence of sorbitol on plant growth and production, and its accumulation and mobility in cowpea. In the study, three experiments were carried out from February 2014 to May 2015. Experiment I was composed of two treatments with nutrient solution under absence (−B) and presence (+B) of boron in ten repetitions. In the experiment II, a 5 × 2 factorial scheme was used, being applied via foliar five concentrations of B (0, 1.25, 2.5, 3.75 and 5.0 g L−1 of B) in the form of boric acid and in the absence or presence of sorbitol (500 mmol L−1 ), with four repetitions. In the experiment III, marked boron (10B) mobility was studied regarding its absorption by roots and leaves. Boron deficiency symptoms, root growth, dry weight of plant organs and B content and grain production were assessed. Boron deficiency in cowpea plants decreased B absorption efficiency, although it has increased nutrient use efficiency. The greatest losses occurred in reproductive variables and root growth in relation to leaves and stem production. Boron deficiency induces cellular changes such as thickening in the middle lamella and starch accumulation in leaf chloroplasts, which lead to characteristic visual symptoms for cowpea. The highest production of cowpea grains (90-100% of maximum production) occurred when B was pulverized at 2.62 g L−1 of B without sorbitol, having as a source the boric acid, on growth stages V6, R1 and R2 and foliar ... (Complete abstract click electronic access below)
Doutor
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Reddy, Direshni. "Power management of a 1kW HTPEMFC based CHP system." Master's thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/10683.
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Includes bibliographical references (leaves 142-149).There is a growing interest in fuel cell technology for portable, stationary and transportation applications. This is driven by the need for a greener and more fuel efficient energy generation source. Fuel cells are electrochemical energy generating devices, which require natural gas for the production of electrical and thermal power, simultaneously.
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Tortel, Vincent. "Conception d'un générateur d'impulsion de 1kJ pour le magnétoformage." Lille 1, 1993. http://www.theses.fr/1993LIL10035.
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Ce travail concerne le magnetoformage a niveau d'energie faible et moyenne (quelques kj), autorisant l'emploi de semi-conducteurs au silicium en place des ignitrons traditionnellement utilises. Une presentation du magnetoformage est effectuee, elle rappelle les principes, et les elements materiels utilises. Des etudes d'optimisation sont developpees, elles concernent entre autres l'absorption du champ magnetique et l'influence du compromis temps de vol duree d'impulsion, sur la vitesse de la piece a former. Il est ainsi montre qu'il suffit d'une impulsion unique (demi-periode de sinusoide) pour assurer un formage correct. Dans ce cas il sera possible d'augmenter la frequence du generateur. Celui-ci est concu avec cet objectif. Le generateur est etudie et plus principalement l'interrupteur. Differentes reflexions ont conduit a la realisation d'une structure particuliere, a partir d'association, serie/parallele, de thyristors a vitesse de croissance maximale du courant elevee (di/dt). Un prototype a ete fabrique, dans un souci de parfaite symetrie de revolution (disposition coaxiale) afin de reduire les desequilibres lies a la dispersion des semi-conducteurs et aux inductances de liaison et de connexion. Une recherche d'optimum sur la repartition des courants a initialise la conception d'elements de commande rapprochee. Un dispositif de charge du condensateur reservoir d'energie autorisant le fonctionnement a cadence elevee est developpe. Cette realisation peut servir de base pour des montages mettant en jeu une energie superieure.
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Gerhardt, Sibel [Verfasser]. "§13b UStG im Insolvenzverfahren : Bewältigung der Bauträgerfälle / Sibel Gerhardt." Frankfurt a.M. : Peter Lang GmbH, Internationaler Verlag der Wissenschaften, 2020. http://d-nb.info/1216397724/34.
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Hahm, Dahn. "Modulation of NK Cell Function with Agonistic α-CD137 Antibodies During MCMV Infection." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36710.
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The Tumor Necrosis Factor Receptor Superfamily (TNFR) is responsible in regulating a myriad of physiological function including the regulation of the immune system. Among the members include CD137 (4-1BB), an inducible costimulatory receptor known for its potent activation, proliferation, and survival effects on T cells. Stimulation of NK cells with agonistic α-CD137 antibodies are known to increase IFN-γ production and proliferation in NK cells as well as increase efficacy of anti-tumor responses. However, NK cell death has also been seen in certain circumstances, although the mechanism remains to be determined. In vitro stimulation of NK cells revealed that α-CD137 induced NK cell death occurs through both TNFR1 and TNFR2, although the action of TNF-α and TNF-ß remain uncertain. Death was independent of other cytotoxic mechanisms such as granzyme/perforin, Fas-Fas ligand, and TRAIL. During MCMV infection, α-CD137 induces NK cell death during the early phase of infection reducing viral resistance. This causes increased viral proliferation which drives NK cell proliferation, likely through Ly49H-m157 interactions, to high levels by day 4 of infection. The use of α-CD137 as a tumor therapeutic is promising with several applications undergoing clinical trials. However, my results raise concern of other effects including the depletion of NK cells. This may cause a temporary impairment in immune function against pathogenic infections and a compensatory reaction of NK cell proliferation, both of which may cause damage to the host. However, with proper co-stimulation or co-treatments, this impairment may be overcome and prevent adverse effects in patients.
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Gilardy, Gwenaelle. "Measuring the 7Li(a ; g)11B reaction rate at temperatures relevant for the n-process." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0398/document.
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L’étude des réaction (a,g) d’intérêt astrophysique est vaste. Ces réactions ont un rôle important dans la phase de fusion d’hélium des étoiles, dans la nucléosynthèse au moment du big bang ainsi que dans une grande partie des scénarios d'explosions stellaires. L’étude des réactions (a,g) impliquant des faisceaux stables peut être réalisée de diverse façon. Je me suis concentrée sur deux d'entre elles. La première est l’étude en cinématique directe en détectant les rayons gamma produits. C'est ce que j'ai fait durant ma thèse pour mesurer la section efficace de 7Li(a,g)11B. Cette réaction a été étudiée au cours des années pour différentes raisons en astrophysique nucléaire. Par exemple, il a été postule que cette réaction pourrait résoudre, au moment de la nucléosynthèse du big bang, le problème du Lithium. Il est clair, aujourd'hui, que ce n'est pas la solution, cependant, elle a un rôle dans la production de boron lors des supernovae de type Ic. Une autre façon d’étudier les réactions (a,g) est d'utiliser la cinématique inverse. L’idée est d'envoyer un faisceau d'ions lourd sur une cible d’hélium. Ce type de cinématique permet de détecter, avec une bonne efficacité, le noyau lourd de recul produit si le faisceau qui n'a pas interagit avec la cible, en est correctement séparé. Les séparateurs de masses, comme St. George, sont construit dans ce but. St. George sera impliquer dans la mesure de sections efficaces de réaction d’importance pour le processus s comme 16O(a,g)20NeThe study of (a,g) reactions of astrophysical interest is quite vast. These reactions play an important role in the quiescent Helium burning phase of stars, in big bang nucleosynthesis and in most explosive stellar scenarios. The studies of (a,g) reactions involving stable beams are performed in various ways. I have been concentrating on two of them. The first one is studying these reactions in direct kinematics by detecting the produced gamma rays. This is what I did during my thesis to measure the cross section of 7Li(a,g)11B. It has been studied throughout the years for several purposes in nuclear astrophysics. For example, it was postulated it could solve the big bang nucleosynthesis Lithium problem. Nowadays, it is clear it does not.However, this reaction plays a role in the production of Boron during type Ic Supernovae. Another way to study (a,g) reactions is to use inverse kinematics. The idea is to send a heavy element beam on a Helium target. This kind of kinematics allows for the detection, with good efficiency, of the heavy recoil product if the beam that did not interact in the target is properly separated. Recoil mass separators, like St. George, are built for this purpose. St. George will be involved in measuring cross sections of reaction important for the s-process like 16O(a,g)20Ne
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Cannons, Jennifer. "Signal transduction by the T cell costimulatory receptor, 4-1BB." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ63680.pdf.
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Haigh, Peter James. "The search for molecular cluster structures in 11B and 14C." Thesis, University of Birmingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.532309.
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Moriarty, Charlotte M. Harwood. "Functional Analysis of MicroRNA-10b in Breast Carcinoma: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/426.
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MicroRNAs (miRNAs) represent a class of small noncoding RNAs that regulate gene expression. Recent studies have shown that miRNAs are mis-expressed in various human cancers and that some miRNAs have the potential to act as tumor suppressors or oncogenes. MiR-10b is one miRNA that has been shown to be deregulated in breast cancer. However, current findings regarding miR-10b’s role in breast cancer are controversial. MiR-10b was originally reported to be downregulated in breast cancer compared to normal breast tissue. Subsequently, miR-10b was argued to be upregulated in metastatic breast cancer cell lines, acting as a potent pro-metastatic agent via regulation of HOXD10. This report was soon challenged by another group who reported that miR-10b expression in a large patient cohort correlated inversely and significantly with tumor size, grade, and vascular invasion, but did not correlate with development of distant metastases or survival. These latter data suggest that miR-10b may impede specific functions associated with breast cancer progression.
In this thesis, I present my analysis of miR-10b function in breast carcinoma cells, which revealed that it suppresses their migration and invasion. To define a mechanism that accounts for this suppressive function, I identified T-lymphoma invasion and metastasis 1 (TIAM1), a guanine nucleotide exchange factor for Rac1, as a miR-10b target and demonstrated that miR-10b inhibits TIAM1-dependent Rac1 activation, migration, and invasion. In addition, I identified the VEGF receptor fms-related tyrosine kinase 1 (FLT-1) as a second target of miR-10b and discovered a novel function for FLT-1 in promoting breast carcinoma cell migration and invasion. My results show, for the first time, that Rac activation can be regulated by a specific miRNA and provide a novel mechanism for the regulation of TIAM1 and FLT-1 in breast cancer. These data support the conclusion from clinical data that miR-10b expression correlates inversely with breast cancer progression, and suggest that miR-10b functions to impede breast carcinoma progression by regulating key target genes involved in cell motility.
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DAMIANI, FRANCESCO. "11ß-HSD1: novel roles and implications in pathology and physiology of reproduction and in skin homeostasis." Doctoral thesis, Università di Siena, 2017. http://hdl.handle.net/11365/1005619.
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My three-years work focused on the enzyme 11B-HSD1 and its implications and roles in human reproduction and skin homeostasis. The enzyme is involved in the local regulation of glucocorticoids availability, being responsible of the cortisone activation to cortisol. My project was composed of three major parts.
In the first section, I analyzed the role of the enzyme in the human first trimester decidua. My experiments included a global evaluation of the enzyme susceptibility to respond to hormonal and cytokine stimuli, driving the first part of pregnancy. Our findings reported that 11B-HSD1 expression and activity are stimulated by a combined treatment of estradiol and medroxyprogesterone (used as analogue of progesterone). In parallel experiments, we demonstrated that also interleukin 1, alone and in combination with interferon-, has the ability to increase expression and activity of the enzyme. In the same work, that resulted in a paper published on Molecular and Cellular Endocrinology, we reported that elevated expression levels of 11B-HSD1 in decidua correlated with development of preeclampsia, suggesting a possible implication of the enzyme also in a pathological onset.
In the second section, I investigated the role of 11B-HSD1 in the second part of gestation, using a dual-model approach involving murine and human uterus. We demonstrated the close correlation between pregnancy progression and 11B-HSD1 expression levels. In particular, after an early stable state, we observed a progressive increase of the mRNA and protein expression of the enzyme from mid-pregnancy to the last day of murine pregnancy, followed by an expression drop at the onset of labour. Our experiments with human cells reported also that 11B-HSD1 is involved in myometrium contraction, suggesting that enzyme has an essential role also in the mechanism of labour.
In the last part of my thesis, I explored the skin pathology of psoriasis and one of its possible medical treatments, narrow-band UVB irradiation. In our preliminary experiments, we studied the expression levels of 11B-HSD1 before and after this medical approach on psoriatic patients, comparing results with control subjects. Our findings showed that controls and patients before the treatments have similar 11B-HSD1 expression levels. After the treatment period, mRNA and protein expression of the enzyme significantly rose up, suggesting a possible involvement of the 11-HSD1 in the molecular mechanism of the symptoms improvement.
Globally, we reported a new vision of 11B-HSD1, with involvement in physiology and pathology of gestation and skin, never observed in previous reports, highlighting new perspectives in roles and ‘specific weight’ of the enzyme in organs and tissues different from the classic targets of 11B-HSD1.
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Granja, Ana Carolina Ribeiro. "Separação dos isótopos estáveis de boro, por troca iônica em sistema cascata, e obtenção de H310BO3 enriquecido em 10B." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/64/64135/tde-17012014-113125/.
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O método cromatográfico de troca iônica, em colunas de resina foi empregado no estudo do enriquecimento isotópico de 10B e H3 10BO3. Em dois sistemas cromatográficos de colunas (S1: seis colunas de acrílico de 1800 mm de comprimento e 70 mm de diâmetro interno; S2: seis colunas de acrílico de 1800 mm de comprimento e 30 mm de diâmetro interno) foi estudado a separação do isótopo 10B, no equilíbrio envolvendo ácido bórico em solução aquosa e íons borato adsorvidos em resina aniônica do tipo amônio quaternário (Dowex 1X8), 100 - 200 \"mesh\". Os sistemas de produção de H3 10BO3 foram avaliados individualmente e em processo cascata, com transferência de 10B entre os dois sistemas. As determinações de B no presente trabalho foram avaliadas por espectrometria de massas com plasma e espetrometria de massas por termoionização. No sistema S1 de colunas após 243 m (135 DBC) de deslocamento foi possível obter um enriquecimento médio, nos últimos 20 cm, de 40 % em átomos de 10B, correspondendo a 2830 mg de H3 10BO3. Essa massa foi transferida (interação) para o sistema S2 de colunas que apresentava, nos últimos 20 cm da banda, enriquecimento médio de 47,8 % em átomos de 10B e essa nova banda cromatográfica foi deslocada por 21,6 m, obtendo-se no último centímetro da banda (1 - 0 cm) da fração enriquecida 82 % em átomos de 10B. O fator de fracionamento (\'alfa\') e a altura equivalente de uma placa teórica dos isótopos estáveis de B (10B e 11B) foi determinado como sendo 1,0245 e 0,30 cm, respectivamenteThe chromatographic method of ion exchange resin in columns was used to study the isotopic enrichment of 10B and H3 10BO3. In two column chromatographic systems (S1: six acrylic columns 1800 mm length and 70 mm diameter; S2: six acrylic columns 1800 mm length and 30 mm diameter) was studied 10B isotope separation in equilibrium involving aqueous boric acid and borate ions adsorbed on anionic resin of the quaternary ammonium type (Dowex 1X8) 100-200 \"mesh\". The production systems H3 10BO3 were evaluated individually and in cascade process with 10B transfer between both systems. The measurements of B in this study were evaluated by Inductively Coupled Plasma Mass Spectrometry and Thermal Ionization Mass Spectrometry. In the S1 columns system displacement after 243 m (135 DBC) was possible obtain an medium enrichment in the last 20 cm, of 40 % atoms 10B, corresponding to 2830 mg of H310BO3. This mass was transferred to the S2 column system which have introduced in the last 20 cm of the band medium enrichment of 47,8 atom% 10B and this new band chromatography was displaced 21,6 m, thus obtaining the last centimeter band (1-0 cm) from enriched fraction 82 % atoms 10B. The fractionation factor (\'alfa\') and the Height Equivalent of Theoretical Plate (HETP) of stable isotopes of B (10B and 11B) was determined like being 1,0245 and 0,30 cm, respectively
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Book, Stefan. "1kW Class-E solid state power amplifier for cyclotron RF-source." Thesis, Uppsala universitet, FREIA, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-341693.
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This thesis discusses the design, construction and testing of a highefficiency, 100 MHz, 1 kW, Class-E solid state power amplifier. The design was performed with the aid of computer simulations using electronic design software (ADS). The amplifier was constructed around Ampleon's BLF188XR LDMOS transistor in a single ended design. The results for 100 MHz operation show a power added efficiency of 82% at 1200 W pulsed power output. For operation at 102 MHz results show a power added efficiency of 86% at 1050 W pulsed power output. Measurements of the drain- and gate voltage waveforms provide validation of Class-E operation.
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Lapsys, Naras Mykolas. "The FRA 16B locus : long range restriction mapping of 16q13-16q22.1 /." Title page, table of contents and summary only, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09phl317.pdf.
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Keung, Wen-yee Wendy, and 姜韻兒. "Mechanisms of acute actions of 17B-estradiol in the vascular system." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B29697487.
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Zarkadis, D. J. "16Kb/s APC and 9.6Kb/s RELP for satellite mobile systems." Thesis, University of Surrey, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378213.
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Sergeant, Catherine Anne. "The influence of S. frutescens on adrenal cytochrome P450 11B-hydroxylase." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/2488.
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Thesis (MSc (Biochemistry))--University of Stellenbosch, 2009.ENGLISH ABSTRACT: This study: 1. describes the preparation of a methanol extract of Sutherlandia frutescens and the HPLC fractionation of the methanol extract. 2. investigates the influence of S. frutescens on the binding properties of mitochondrial cytochrome 11 -hydroxylase (CYP11B1) to deoxycorticosterone (DOC) and deoxycortisol, demonstrating that methanol extracts of S. frutescens inhibit the Type I substrate-induced difference spectra. 3. investigates the influence of S. frutescens on the catalytic activity of CYP11B1 expressed in COS1 cells, demonstrating that the methanol extract of S. frutescens inhibits the conversion of DOC and deoxycortisol. 4. describes the sequential extraction of the methanol extract of S. frutescens using organic solvents and the inhibition of the conversion of DOC by CYP11B1 expressed in COS1 cells in the presence of these extracts. 5. describes the inhibition of the binding of DOC to CYP11B1 in ovine adrenal mitochondria, and the conversion of DOC by CYP11B1 expressed in COS1 cells by these fractions. 6. identifies the presence of the flavonoid compounds, orientin vitexin and rutin, in S. frutescens. 7. investigates the influence of the flavonoid compounds on the binding of DOC to CYP11B1 and on the catalytic activity of DOC by CYP11B1 expressed in COS1 cells. 8. identifies the presence of the triterpenoid, sutherlandioside A (SU1), in S. frutescens extracts and investigates its effect on the binding of DOC to CYP11B1.
AFRIKAANSE OPSOMMING: Hierdie studie beskryf: 1. die voorbereiding van ‘n metanol ekstraksie van Sutherlandia frutescens en die HPLC fraksionering van die metanol ekstrakte. 2. ‘n ondersoek na die invloed van S. frutescens op die bindingseienskappe van sitochroom P450 11 -hidroksilase (CYP11B1) in skaap bynier mitochondria en demonstreer dat S. frutescens metanol ekstrakte die vorming van steroïed-geinduseerde tipe I verskil spektra van deoksiekortisol en deoksikortikosteroon (DOC) inhibeer. 3. ‘n ondersoek na die invloed van S. frutescens op die katalitiese aktiwiteit van CYP11B1 in COS1 selle en demonstreer die inhibisie van DOC en deoksikortisol omsetting na hul produkte deur die methanol ekstrakte. 4. die opeenvolgende ekstraksie van methanol extrakte van S. frutescens met organiese oplosmiddels en beskryf die inhibisie van die CYP11B1 gekataliseerde omsetting van DOC in COS1selle in die teenwoordigheid van die ekstrakte. 5. die inhibeerende effek op die binding van DOC aan CYP11B1 in skaap bynier mitochondria en die inhibisie van die CYP11B1 gekataliseerde omsetting van DOC in COS1selle. 6. die identifisering van flavonoïed verbindings, orientin vitexin en rutin in S. frutescens. 7. ‘n ondersoek na die invloed van die flavonoïed verbindings op die binding van DOC aan CYP11B1 en op die katalitiese aktiwiteit van CYP11B1 in COS1 selle. 8. die indentifisering van die triterpenoïed, sutherlandiosied A (SU1), in S. frutescens en ondersoek die invloed van SU1 op die binding van DOC aan CYP11B1.
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Bubb, Keith W. "THE EC-18B ARIA: AIRBORNE TELEMETRY AND REENTRY VEHICLE SCORING COMBINED." International Foundation for Telemetering, 1985. http://hdl.handle.net/10150/615743.
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International Telemetering Conference Proceedings / October 28-31, 1985 / Riviera Hotel, Las Vegas, NevadaThe 4950th Test Wing, at Wright-Patterson Air Force Base, Ohio, is converting four Boeing 707-320C aircraft into EC-18B Advanced Range Instrumentation Aircraft (ARIA). In addition to the antenna and electronic equipment required to collect telemetry data in support of NASA and DOD space and missile programs, the EC-18B will be equipped with a Sonobuoy Missile Impact Location System (SMILS), an optics system, and a meteorological sampling system. Once these systems are added, the EC-18B ARIA will be the most versatile and capable airborne mobile instrumentation platform in the world. They will be able to collect telemetry data from various space and missile systems; acoustically determine the geodetic impact point of reentry vehicles at any location; obtain photographic and video data from reentry vehicles as they pass through the earth’s atmosphere; and provide local atmospheric data in support of worldwide US ballistic missile tests through the year 2000 and beyond.
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Guimaraes, Valdir. "ESTUDO DA SECAO DE CHOQUE DE FUSAO DO SISTEMA 11B + 27A1." Universidade de São Paulo, 1988. http://www.teses.usp.br/teses/disponiveis/43/43131/tde-17062015-061743/.
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Investigamos o processo de fusão para o sistema 11B + 27Al dentro do intervalo de energia de bombardeio de 18 Me v
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Stephan, Matthias. "Constitutive expression of costimulatory ligands in tumor antigen-specific human T lymphocytes : a study investigating the therapeutic potential of auto- and transcostimulation in cancer immunotherapy /." Access full-text from WCMC, 2008. http://proquest.umi.com/pqdweb?did=1528351841&sid=9&Fmt=2&clientId=8424&RQT=309&VName=PQD.
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Nyström, Per. "Läroboksanalys: Matematik 5000 1b." Thesis, Malmö högskola, Fakulteten för lärande och samhälle (LS), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-33523.
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Läroböcker är en viktig del av undervisningen och de kan påverka inlärning, därför är det av intresse att ta reda på vilka beståndsdelar man kan dela in dem i, hur en svensk lärobok ser ut jämfört med andra länders, samt vad forskning säger om hur dessa attribut kan påverka läsaren. Detta har jag gjort i det här arbetet via en textanalys.Textanalyser i allmänhet, och läroboksanalyser i synnerhet, är inget nytt, utan det är en vedertagen metod för att bryta ner texter. I det här arbetet lånar jag analysmetoder från flera olika tidigare forskare och applicerar dem på en svensk lärobok i kursen matematik 1b.Bland de valda attributen finns fysiska egenskaper, språk (pronomen, passiva meningar, specialistord och uppmaningar) och innehåll (berättande text, övningar, aktiviteter och lösta exempel). Bland resultaten märks att författarna till den valda boken har en tydlig närvaro i texten, vilket visas genom ett tätt användande av personliga pronomen i första person (vi). De använder sig även av många aktiviteter och försöker på så sätt bygga en relation med läsaren. Det är positivt att författarna på det här sättet får läsarens förtroende, men för de läsare som inte kan eller vill identifiera sig med det skrivna vi kan det istället få en negativ effekt på lärandet.Specialistord har också en dubbelnatur. De är nödvändiga i specialområden som t.ex matematik, och en positiv effekt de kan ha på lärandet är att de etablerar författaren som en auktoritet. För mycket specialistord kan däremot få motsatt effekt genom att göra texten svårbegriplig.Delar av analysen är svår att applicera på matematisk text, vilket ger en viss osäkerhetsfaktor i just de resultaten.
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Wang, Xiao Qiang. "Function and regulation of 17B-hydroxysteroid dehydrogenase type7 (17B-HSD7) in sex hormone biosynthesis and breast cancer : in vitro, in vivo, proteomic and three dimensional co-culture studies." Doctoral thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/27483.
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La 17β-hydroxystéroïde déshydrogénase humaine de type 7 (17β-HSD7) a une double fonction dans la cholestérologénèse et la stéroïdogénèse, et qui est impliquée à la fois dans la formation d’estradiol (E2) à partir de l’estrone (E1), et dans la dégradation de la dihydrotestostérone (DHT) en un œstrogène faible (3β-diol). Cependant, sa fonction dans le cancer du sein dépendant des œstrogènes (positif aux récepteurs oestrogéniques (RE+) n’a pas toujours été claire. L’E2 stimule la croissance des cellules cancéreuses du sein (CCS; cellules MCF-7) via les RE tandis que la DHT a un effet antiprolifératif via le récepteur des androgènes. Mes études in vitro, in vivo et de protéomique, ont apporté les résultats suivants : (1) L’inhibition de la 17β-HSD7 par un inhibiteur spécifique (INH7) dans les CCS a entrainé une baisse de l’E2, une augmentation de la DHT, une interruption du cycle cellulaire et une régulation négative de cette enzyme. De plus, l’INH7 a permis de réduire des tumeurs xénogreffes qui a été accompagnées d’une diminution de l’E2 et une augmentation de la DHT sériques. (2) L’INH7 a modulé des protéines impliquant différents processus biologiques. L’INH7 a supprimé l’expression de la protéine 78 régulée par le glucose (Grp78) et de fait a augmenté l’apoptose des CCS envers le Letrozole, un inhibiteur de l’aromatase. (3) Les interactions entre les CCS et les fibroblastes tumoraux montrent que la 17β-HSD7 était l’enzyme la plus régulée dans les CCS tandis que l’aromatase était l’enzyme les plus régulées dans les fibroblastes. De telles régulations ont mené à une augmentation de la conversion de l’E2 à partir de ses précurseurs, et a ainsi encouragé la prolifération cellulaire des CCS. Si l’augmentation de la prolifération cellulaire est bloquée par le Letrozole des résultats plus significatifs ont été observés par l’INH7 qui bloque la dégradation de la DHT. (4) L’analyse des données intégratives basée sur The Cancer Genome Atlas (TCGA) confirme l’amplification significative du gène HSD17B7 dans les divers cancers du sein comparé à des tissus mammaires sains. Ainsi, nous pensons que la 17β-HSD7 devrait être une nouvelle cible thérapeutique des cancers RE+ du sein.Human 17β-hydroxysteroid dehydrogenase type 7 (17β-HSD7) displays a dual function in cholesterogenesis and steroidogenesis. In steroidogenesis, it is both involved in the formation of the estradiol (E2) from estrone (E1) and in the degradation of dihydroterstosterone (DHT) into weak estrogen 5α-androstane-3β, 17β-diol (3β-diol). However, its function in estrogen dependent breast cancer (estrogen receptor positive, ER+) has been unclear for many years. E2 stimulates breast cancer cells (BCCs, MCF-7 cells) growth via estrogen receptor (ER) whereas DHT displays anti-proliferative effects via androgen receptor (AR). In the present thesis, the function of 17β-HSD7 in ER+ breast cancer was studied with in vitro, in vivo, proteomics and three dimensional (3D) co-culture model and results were described: (1) Inhibition of 17β-HSD7 by its selective inhibitor (INH7) in BCCs induced significant lower E2, higher DHT, cell cycle arresting and negative regulating of the same enzyme. Such inhibition induced significant shrinkage of xenograft tumors accompanied by decreased E2 and elevated DHT in plasma. (2) Inhibition of 17β-HSD7modulated 104 proteins involved in different biological processes. INH7 especially suppresses the expression of glucose regulated protein 78 (GRP78) and consequently enhanced apoptosis of MCF-7 towards aromatase inhibitor. (3) The interactions between BCCs and tumor fibroblast modulate steroidogenic enzymes. 17β-HSD7 was the most modulated enzyme in MCF-7 cells whereas aromatase was the most regulated enzyme in fibroblast (Hs578Bst). Such regulations led to an increasing of E2 conversion from precursors and promoted MCF-7 cells’ proliferation. The increased cell proliferation was blocked by aromatase inhibitor in 3D co-culture system, but more significant results were observed with INH7 which blocked DHT degradation. (4) Integrative data analysis with The Cancer Genome Atlas (TCGA) confirmed the significant amplification of 17β-HSD7 in various breast cancers compared to normal breast tissue. Thus, in the present thesis, 17β-HSD7 was characterized as a novel therapeutic target for estrogen dependent breast cancer in postmenopausal women.
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Gammon, Tammy Lea. "Improved arcing-fault current models for low-voltage power systems (<1kV)." Diss., Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/15675.
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Sharp, Victoria. "11B-Hydroxysteroid Dehydrogenase Enzymes in the Porcine Testis and Male Reproductive Tract." Thesis, Royal Veterinary College (University of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498908.
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Ota, Shinsuke. "Low-lying proton intruder state in 13B via 4He(12Be,13Bγ) reaction." 京都大学 (Kyoto University), 2009. http://hdl.handle.net/2433/124409.
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Yosoi, Masaru. "Structures and fragmentations of the deep-hole states in 11B and 15N." 京都大学 (Kyoto University), 2003. http://hdl.handle.net/2433/149153.
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do, Carmo Vasconcelos de Carvalho Viviane. "Avaliação dos polimorfismos dos genes INF-Y E IL12B em pacientes com e sem lesões intra-epiteliais cervicas causadas por HPV." Universidade Federal de Pernambuco, 2011. https://repositorio.ufpe.br/handle/123456789/1707.
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Previous issue date: 2011O Papilomavírus Humano (HPV) é um agente sexualmente transmissível capaz de infectar pele e mucosas, sendo o principal causador de câncer cervical e suas lesões precursoras, as Neoplasias Intraepiteliais Cervicais (NICs). A maioria dos casos de infecção pelo HPV regride espontaneamente, mesmo quando o vírus possui genótipo oncogênico. Sabe-se que os componentes genéticos e imunológicos do indivíduo assumem papel importante na eliminação do vírus. Vários estudos sugerem que alguns sítios polimórficos em genes de citocinas levam a variações nos níveis dessas moléculas, o que pode influenciar o desenvolvimento de câncer cervical em pacientes infectadas por HPV. Neste estudo avaliou-se a possível correlação entre a infecção por HPV de alto risco oncogênico e os polimorfismos existentes nas regiões +874 do gene INF-e 3 UTR +1188 do gene IL-12B em amostras de DNA de secreção vaginal. A população estudada foi composta de 76 mulheres saudáveis e 162 mulheres, HPV positivas, com lesão cervical, NIC I (45), NIC II (55), NIC III (53) e câncer cervical (9), na cidade de Recife Brasil. Ao ser avaliado o polimorfismo +874 (T/A), verificou-se que não houve diferença significativa nas distribuições genotípica (p = 0,4192) e alélica (p = 0,370) entre os grupos de pacientes e o grupo controle. Comparando-se as pacientes com NIC de baixo grau com as de alto grau, também não se verificou diferença genotípica (p = 0,8099) e alélica (p = 1,00). Para o gene IL-12B, a presença do genótipo AA (p = 0,009) e do alelo A (p = 0,0038) estavam mais presentes no grupo de pacientes com lesão cervical que no grupo controle. Quando as amostras foram estratificadas de acordo com grau de lesão cervical, o genótipo AA (p = 0,0036) e o alelo A (p = 0,0010) estavam mais freqüentes no grupo com lesão cervical de alto grau que no grupo com lesão cervical de baixo grau. O alelo mutante C mostrou-se importante na proteção contra as lesões. Por outro lado, o polimorfismo +874 T/A no gene INF-Ynão parece interferir no desenvolvimento de lesões cervicais. Estes resultados mostram que diferentes citocinas podem apresentar papéis diferentes na susceptibilidade a infecção e na progressão de lesões cervicais
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Benjelloun, Fahd. "Développement d'anticorps monoclonaux humains de type IgA dirigés contre la partie C-terminale de la protéine d'enveloppe gp41 du VIH-1." Phd thesis, Université Jean Monnet - Saint-Etienne, 2013. http://tel.archives-ouvertes.fr/tel-00999342.
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La transmission du Virus de l'Immunodéficience Humaine (VIH) par voie sexuelle représente le mode majoritaire de contamination (80%) (UNAIDS). Ce mode de contamination implique le passage du virus à travers les muqueuses et une interaction avec les cellules épithéliales et les cellules immunitaires présentes au sein de ces muqueuses (cellules dendritiques, macrophages ou lymphocytes). Les muqueuses représentent le principal site d'exposition de l'organisme aux antigènes de l'environnement. Les SIgA (IgA sécrétoires) présentes dans la lumière de ces muqueuses représentent la première ligne de défense immunitaire contre l'infection et la colonisation des muqueuses. Les IgA sont capables d'interagir avec les glycoprotéines (gp) exprimées à la surface du VIH et de bloquer l'infection et/ou la transcytose à travers l'épithélium muqueux. Nous avons pu étudier la prévalence des SIgA anti-gp41 et plus précisément anti-MPER présentes dans la salive parotidienne de personnes Exposées au VIH Séronégatives (ESN) et leur rôle dans l'inhibition de l'infection par le virus in vitro. Nous avons pu démontrer que ces sujets présentaient un taux plus important de SIgA anti-MPER neutralisantes. Ce premier travail nous a permis de valider la gp41 comme immunogène d'intérêt pour la génération de SIgA neutralisantes. Nous avons pu générer des IgA1 dans un modèle murin α1Kl chimérique capable de produire des anticorps IgA1 humanisés. L'immunisation de ces souris a permis la production de 6 anticorps monoclonaux spécifiques de la région MPER capables de reconnaître des épitopes conformationnels élargis, correspondant aux épitopes reconnus par le 2F5 et le 4E10. Les IgA1 présentaient de fortes capacités neutralisantes pour différentes souches de laboratoire et de souches primaires du VIH. Les études de caractérisation des fonctions antivirales de ces anticorps permettront de mieux définir le mode d'action de ces anticorps. A notre connaissance, ces IgA1 neutralisantes anti-MPER sont les premières décrites à ce jour dans la littérature. De par leur faible immunogénicité et leur faible autoréactivité, ces anticorps peuvent facilement être intégrés dans des approches thérapeutiques locales ou par sérothérapie passive pour la protection après administration de SHIV dans des modèles animaux comme le macaque. L'ensemble de mes travaux de thèse ont confirmé l'intérêt thérapeutique potentiel des SIgA dans la lutte contre le VIH et notamment celles dirigées contre la partie gp41 de l'enveloppe
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Lebiedz, Dirk. "Wasserstoffinduzierte Effekte im System Nd2(Fe/Co)14B eine SIMS- und XPS-Studie /." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=967429897.
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Bell, Taylor J., Nikolay Nikolov, Nicolas B. Cowan, Joanna K. Barstow, Travis S. Barman, Ian J. M. Crossfield, Neale P. Gibson, et al. "The Very Low Albedo of WASP-12b from Spectral Eclipse Observations with Hubble." IOP PUBLISHING LTD, 2017. http://hdl.handle.net/10150/625800.
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We present an optical eclipse observation of the hot Jupiter WASP-12b using the Space Telescope Imaging Spectrograph on board the Hubble Space Telescope. These spectra allow us to place an upper limit of A(g) < 0.064 (97.5% confidence level) on the planet's white light geometric albedo across 290-570 nm. Using six wavelength bins across the same wavelength range also produces stringent limits on the geometric albedo for all bins. However, our uncertainties in eclipse depth are similar to 40% greater than the Poisson limit and may be limited by the intrinsic variability of the Sun-like host star-the solar luminosity is known to vary at the 10(-4) level on a timescale of minutes. We use our eclipse depth limits to test two previously suggested atmospheric models for this planet: Mie scattering from an aluminum-oxide haze or cloud-free Rayleigh scattering. Our stringent nondetection rules out both models and is consistent with thermal emission plus weak Rayleigh scattering from atomic hydrogen and helium. Our results are in stark contrast with those for the much cooler HD 189733b, the only other hot Jupiter with spectrally resolved reflected light observations; those data showed an increase in albedo with decreasing wavelength. The fact that the first two exoplanets with optical albedo spectra exhibit significant differences demonstrates the importance of spectrally resolved reflected light observations and highlights the great diversity among hot Jupiters.
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Saoulli, Catherine. "CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0008/MQ40765.pdf.
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Louw, Lilly-Ann. "Analysis of an 18kb accessory region of plasmid pTcM1 from Acidithiobacillus caldus MNG." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/1667.
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Thesis (MSc (Microbiology))--University of Stellenbosch, 2009.Biomining organisms are generally found in metal-rich, inorganic environments such as iron and sulfur containing ores; where they play a vital role in mineralization and decomposition of minerals. They are typically obligatory acidophilic, mesophilic or thermophilic, autotrophic, usually aerobic, iron-or sulfur oxidizing chemolithotrophic bacteria. The most prominent biomining organisms used in bioleaching of metal sulfides are Acidithiobacillus ferrooxidans, At. thiooxidans, At. caldus, Sulfobacillus spp. and Leptospirillum spp. Biomining enables us to utilize low grade ores that would not have been utilized by conventional methods of mining. Research has focused on the backbone features of plasmids isolated from bacteria of biomining environments. The aim of this study is to sequence and analyze an 18 kb region of the 66 kb plasmid pTcM1 isolated from At. caldus MNG, focusing on accessory genes carried by this plasmid. Fifteen putative genes / open reading frames were identified with functions relating to metabolism and transport systems. The genes are located in two divergently located operons. The first operon carries features related to general metabolism activities and consists of a transcriptional regulator (ORF 2), a succinate / fumarate dehydrogenase-like subunit (ORF 3), two ferredoxin genes (ORF 4 and ORF 7), a putative HEAT-like repeat (ORF 6) which is interrupted by an insertion sequence (ORF 5) and a GOGAT-like subunit (ORF 8). The second operon contains an ABC-type nitrate / sulfonate bicarbonate-like gene (ORF 9), a binding protein-dependent inner membrane component-like gene, another ABC sulfonate / nitrate-like gene (ORF 12i and 12ii) which is interrupted by an insertion sequence (ORF 13) and two hypothetical proteins with unknown functions (ORF 14 and ORF 15). Southern hybridization analysis have shown that most of the genes from the two operons are found in other At caldus strains #6, “f”, C-SH12 and BC13 from different geographical locations. Expression of the GOGAT-like subunit and the succinate / fumarate-like subunit was demonstrated in At. caldus MNG showing that these genes are functional and actively transcribed. The transcriptional regulator (ORF 2) has been shown to repress the downstream genes of putative operon 1. The persistence of these genes on plasmids together with the fact that they are being expressed, represents a potential metabolic burden, which begs the question why they have been maintained on the plasmid from geographically separated strains (and perhaps also growing under very different nutrient availability conditions) and therefore what possible role they may play.
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Zevallos, Erick Oscar Natividad. "Investigação do espalhamento elástico do núcleo radioativo 12B em um alvo de 58Ni." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/43/43134/tde-24092018-200026/.
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No presente trabalho medimos e analisamos distribuições angulares para o processo de espalhamento elástico do núcleo radioativo de 12B em alvo de 58Ni. As medidas foram realizadas nas energias de Elab=30.0 e 33.0 MeV no laboratório do acelerador Pelletron. Essas energias são próximas a barreira Coulombiana (VB=28.0 MeV) para esse sistema. Para a produção do feixe radioativo de 12B utilizamos o sistema RIBRAS instalado nesse laboratório. As distribuições angulares foram analisadas com o modelo ótico, utilizando potenciais de Woods-Saxon e Potencial de São Paulo. Para uma interpretação física mais consistente e um estudo da influência de outros canais de reação no espalhamento elástico analisamos também considerando o método de canais acoplados. Considerando o acoplamento dos canais de espalhamento inelásticos, reorientação e spin-órbita pudemos descrever a distribuição angular na energia de 30.0 MeV. No entanto esses canais não foram suficientes para descrever a distribuição angular na energia de 33.0 MeV, indicando que outros canais como de transferência e/ou break-up possam ser importes. A partir da análise das distribuições angulares com modelo ótico obtivemos também a seção de choque total de reação. Essas seções de choque foram comparadas com a de outros sistemas utilizando métodos de redução, indicando que o projétil 12B segue uma sistemática intermediária entre núcleos fortemente ligados e fracamente ligados. Finalmente, discutimos a sistemática dos resultados de canais acoplados para o espalhamento elásticos dos isótopos de Boro 8,10,11,12B no alvo 58Ni em termos da configuração de clusters dos projéteis.In the present work we measure and analyzed angular distributions for the process of elastic scattering of the radioactive nucleus of 12B in a target of 58Ni. The measurements were performed in the energies of Elab = 30.0 and 33.0 MeV in the Pelletron accelerator laboratory. These energies are close to the Colombian barrier (VB = 28.0 MeV) for this system. For the production of the radioactive beam of 12B we used the RIBRAS system installed in this laboratory. The angular distributions were analyzed with the optical model, using potentials of Woods-Saxon and Potential of São Paulo. For a more consistent physical interpretation and a study of the influence of other reaction channels in the elastic scattering we also analyze the coupled channel method. Considering the coupling of the inelastic scattering channels, reorientation and spin-orbit we could describe the angular distribution in the energy of 30.0 MeV. However, these channels were not enough to describe the angular distribution in the energy of 33.0 MeV, indicating that other channels as transfer and / or break-up can be amounts. From the analysis of the angular distributions with optical model we also obtained the section of total reaction shock. These cross sections were compared with those of other systems using reduction methods, indicating that projectile 12B follows a systematic intermediate between tightly bound and weakly bonded cores. Finally, we discuss the systematics of the results of elastic scattering channels of the Boron isotopes 8,10,11,12B in the 58Ni target in terms of the cluster configuration of the projectiles.
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Bernardelli, Jossy Karla Brasil. "Biodegradação de estrona, 17B-estradiol e 17A-etinilestradiol em sistemas aeróbios de tratamento." reponame:Repositório Institucional da UFSC, 2014. https://repositorio.ufsc.br/xmlui/handle/123456789/132954.
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Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Ambiental, Florianópolis, 2014Made available in DSpace on 2015-05-19T04:02:36Z (GMT). No. of bitstreams: 1 333386.pdf: 2765398 bytes, checksum: 958506392e40a3a664199cb4d989de75 (MD5) Previous issue date: 2014
Os estrogênios, presentes no meio aquático como contaminantes e classificados como desreguladores endócrinos, são substâncias com comprovado efeito maléfico aos ecossistemas aquáticos e aos seres vivos, portanto, torna-se necessária a remoção destes poluentes dos esgotos sanitários. Com isto, neste trabalho foi avaliada a remoção simultânea dos hormônios estrona (E1), 17ß-estradiol (E2) e 17a-etinilestradiol (EE2) em condições aeróbias. Neste contexto, foram realizados ensaios de bancada aeróbios de curta duração, conduzidos em diferentes condições operacionais (três concentrações de sólidos suspensos voláteis e da fonte de carbono, três tipos de meio aquoso, lodo inativado e lodo ativado proveniente de três plantas de tratamento diferentes), com o intuito de verificar a relação destas variáveis com a remoção dos hormônios. Além disso, um reator de enriquecimento foi monitorado, para verificar a degradação dos estrogênios a partir da microbiota, sendo que a única fonte de carbono externa adicionada ao sistema foram os hormônios (E1, E2 e EE2). Por fim, dois sistemas piloto de tratamento de esgoto sanitário, lodos ativados (LA) e biorreator a membrana (MBR), foram monitorados para observar a degradação ou a remoção da fase aquosa dos poluentes de interesse. O E2 foi degradado mais facilmente em todos os casos avaliados. Nos experimentos com o lodo inativado, o composto sintético EE2 foi removido mais rapidamente, pelo processo de adsorção, do que os compostos naturais. Um consórcio bacteriano foi obtido através do enriquecimento, e a sua capacidade de degradação foi comprovada. A diversidade da comunidade bacteriana presente em cada amostra de lodo foi estudada, possibilitando a comparação da diversidade das bactérias dominantes, existentes em cada um dos sistemas. Os reatores LA e MBR apresentaram eficiência de remoção dos hormônios bastante semelhante, sugerindo que a presença da membrana como forma de retenção da biomassa no sistema, pode ser substituída por sistemas mais simplificados como os lodos ativados operados em batelada sequencial. A ocorrência do processo de nitrificação foi o principal fator relacionado à eficiência de remoção dos hormônios observada neste trabalho.
Abstract: The estrogens, present in the aquatic environment as contaminants and classified as endocrine disrupting compounds, are substances with proven harmful effects to the aquatic ecosystems, therefore, it becomes necessary to remove these pollutants from sewage. Thus, the simultaneous removal of the hormones estrone (E1), 17ß-estradiol (E2) and 17a-ethinylestradiol (EE2) under aerobic conditions were evaluated in this work. In this context, aerobic batch tests of short duration, conducted under different operating conditions (three concentrations of volatile suspended solids and carbon source, three types of aqueous media, deactivated sludge and activated sludge from three different pants) were performed, in order to verify the relationship between these variables with the estrogens removal. Moreover, an enrichment reactor was monitored, to check the degradation of estrogens from the microbiota, whereas the hormones were the only external carbon source added to the system. Finally, two systems of wastewater treatment, activated sludge (AS) and membrane bioreactor (MBR), were monitored to observe the degradation or elimination from the aqueous phase of the pollutants of interest. The E2 was more easily degraded in all cases evaluated. In experiments with the sludge inactivated, the synthetic compound EE2 was more quickly removed by adsorption than the natural compounds. A bacterial consortium was obtained by enrichment, and its degradation capacity was proven. The structure of bacterial communities present in each sample was studied, allowing comparison of the diversity of dominant bacteria present in each system. The reactors AS and MBR showed removal efficiency hormones quite similar, suggesting that the presence of the membrane retains the biomass in the system, can be replaced by a more simplified system such as activated sludge sequencing batch reactor. The occurrence of the nitrification process was the main factor related to the removal efficiency of hormones observed in this work.