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Journal articles on the topic '1FPC'

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Published: 27 July 2024

Last updated: 30 July 2024

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1

Choi, Junesang, Shantha Kumari Kurumujji, Adem Kilicman, and Arjun Kumar Rathie. "Certain Integral Formulae Associated with the Product of Generalized Hypergeometric Series and Several Elementary Functions Derived from Formulas for the Beta Function." Symmetry 14, no. 2 (February 15, 2022): 389. http://dx.doi.org/10.3390/sym14020389.

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The literature has an astonishingly large number of integral formulae involving a range of special functions. In this paper, by using three Beta function formulae, we aim to establish three integral formulas whose integrands are products of the generalized hypergeometric series p+1Fp and the integrands of the three Beta function formulae. Among the many particular instances for our formulae, several are stated clearly. Moreover, an intriguing inequality that emerges throughout the proving procedure is shown. It is worth noting that the three integral formulae shown here may be expanded further by using a variety of more generalized special functions than p+1Fp. Symmetry occurs naturally in the Beta and p+1Fp functions, which are two of the most important functions discussed in this study.

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McMahon, John J., Jason P. Lake, Callum Stratford, and Paul Comfort. "A Proposed Method for Evaluating Drop Jump Performance with One Force Platform." Biomechanics 1, no. 2 (July 16, 2021): 178–89. http://dx.doi.org/10.3390/biomechanics1020015.

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The drop jump (DJ) is commonly utilised to assess athletes. The criterion two force platform (2FP) method of assessing DJ performance involves two adjacent force platforms, one for the box and one for the athlete to rebound from. Most researchers and practitioners only have access to one force platform (1FP) and they rarely account for the often considerable discrepancy between box height and drop height (DH). Therefore, this study aimed to determine the criterion validity of evaluating DJ performance with 1FP. Twenty-six young male sports students performed three DJs, from a 0.30 m and 0.40 m high box, on two adjacent force platforms. The DH, touchdown velocity and several performance variables were calculated using the 2FP and 1FP methods. Ordinary least-products regression identified no fixed or proportional bias between methods for any DJ variable. The mean DH was 10% lower than the 0.30 m box and 14% lower than the 0.40 m high box. This discrepancy highlights the importance of accounting for DH when conducting DJ assessments. In conclusion, the 1FP method of evaluating DJ performance is a valid alternative to the criterion 2FP method and could be embedded into automated force analysis software for researchers and practitioners to utilise.

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3

Gao, Jian, and Qiong Kong. "1-Generator quasi-cyclic codes over Fpm+uFpm+...+us−1Fpm." Journal of the Franklin Institute 350, no. 10 (December 2013): 3260–76. http://dx.doi.org/10.1016/j.jfranklin.2013.08.001.

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4

Wang, Kai, Xin Song, Xiao Guo, Yunhao Wang, Xue Lai, Fei Meng, Mengzhen Du, et al. "Efficient as-cast thick film small-molecule organic solar cell with less fluorination on the donor." Materials Chemistry Frontiers 4, no. 1 (2020): 206–12. http://dx.doi.org/10.1039/c9qm00605b.

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Less fluorination, better performance! Devices based on DI3T-1F:PC₇₁BM and DI3T-2F:PC₇₁BM are fabricated for thick-film small molecule-solar cells (SMSCs). Indeed, the devices based on DI3T-1F the devices based on DI3T-1F show a better tolerance to thickness, giving PCE of 8.33% with ∼150 nm, and 5.43% with ∼300 nm, which are 14% and 50% higher than those of DI3T-2F, respectively.

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Fox, Lyndsey R., Stephen Stukins, Tom Hill, and Haydon Bailey. "New species of Cenozoic benthic foraminifera from the former British Petroleum micropalaeontology collection." Journal of Micropalaeontology 37, no. 1 (January 5, 2018): 11–16. http://dx.doi.org/10.5194/jm-37-11-2018.

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Abstract. This paper describes four new Cenozoic, deep-water benthic foraminifera from the reference collections at the Natural History Museum in London. The focus is on selected calcareous taxa that are of stratigraphical and/or palaeoecological significance for academic and industrial-related activities. Alabamina heyae (urn:lsid:zoobank.org:act:1E8A66E9-1F4C-4B61-BA97-6E0ECCD0173E), Nonion cepa (urn:lsid:zoobank.org:act:9F36350A-1E49-4D69-B2CC-C83F343E2952), Uvigerina kingi (urn:lsid:zoobank.org:act:C36C89C2-2E65-4FF6-9368-C169B4591995) and Lenticulina stewarti (urn:lsid:zoobank.org:act:485AE871-CECA-44E8-ABD1-BAE2961FFD59) are described with new illustrations. Their biostratigraphic and palaeoecological significance is briefly discussed.

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Ernst, Andrej, Karl Krainer, and Spencer G. Lucas. "Bryozoan fauna of the Lake Valley Formation (Mississippian), New Mexico." Journal of Paleontology 92, no. 4 (April 2, 2018): 577–95. http://dx.doi.org/10.1017/jpa.2017.146.

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AbstractTen bryozoan species are described from the Andrecito and Tierra Blanca members of the Lake Valley Formation (Mississippian) of Sierra County, New Mexico, USA. One genus, with one species, is new—a cystoporate, Cystomeson sierraensis n. gen. n. sp. The bryozoans indicate quieter and deeper conditions in the Andrecito Member and more agitated and shallower conditions in the Tierra Blanca Member. The species identified in this study are endemic to North America, whereas at the generic level, the composition is rather cosmopolitan.UUID: http://zoobank.org/fc354A60-1fbc-4e41-8b9b-bbfd65e59a71

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Han, Mu, Youpei Ye, Shixin Zhu, Chungen Xu, and Bennian Dou. "Cyclic codes over R=Fp+uFp+⋯+uk−1Fp with length psn." Information Sciences 181, no. 4 (February 15, 2011): 926–34. http://dx.doi.org/10.1016/j.ins.2010.10.021.

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8

COFFEY, MARK W. "ON HYPERGEOMETRIC SERIES REDUCTIONS FROM INTEGRAL REPRESENTATIONS, THE KAMPÉ DE FÉRIET FUNCTION AND ELSEWHERE." International Journal of Modern Physics B 19, no. 30 (December 10, 2005): 4483–93. http://dx.doi.org/10.1142/s0217979205032814.

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Single variable hypergeometric functions pFq arise in connection with the power series solution of the Schrödinger equation or in the summation of perturbation expansions in quantum mechanics. For these applications, it is of interest to obtain analytic expressions, and we present the reduction of a number of cases of pFp and p+1Fp, mainly for p=2 and p=3. These and related series have additional applications in quantum and statistical physics and chemistry.

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9

Dem??ralp, Metin, and Sevda Üsküplü. "Matrix Algebraic Infinite Product Representation for Generalized Hypergeometric Functions of Typep+1Fp." Applied Numerical Analysis & Computational Mathematics 2, no. 2 (August 2005): 212–26. http://dx.doi.org/10.1002/anac.200410036.

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10

Petsalakis, Ioannis D., John C. Polanyi, and Giannoula Theodorakopoulos. "Theoretical study of benzene, toluene, and dibromobenzene at a Si(111)7×7 surface." Israel Journal of Chemistry 45, no. 1-2 (May 2005): 111–26. http://dx.doi.org/10.1560/yucw-mve0-6bf0-1fpl.

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11

Herman Steensma and Lisette Otto. "Perception of Performance Appraisal by Employees and Supervisors: Self-Serving Bias and Procedural Justice." Journal of Collective Negotiations (formerly Journal of Collective Negotiations in the Public Sector) 29, no. 4 (December 1, 2000): 307–19. http://dx.doi.org/10.2190/0g8p-ln2f-1fdc-ggap.

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12

Shymkus, Susan. "Professional Perspectives." Laboratory Medicine 31, no. 4 (April 2000): 189–91. http://dx.doi.org/10.1309/79ww-cnr1-f8jr-1fp4.

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13

Bühring, Wolfgang. "Transformation formulas for terminating Saalschützian hypergeometric series of unit argument." Journal of Applied Mathematics and Stochastic Analysis 8, no. 2 (January 1, 1995): 189–94. http://dx.doi.org/10.1155/s1048953395000177.

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Transformation formulas for terminating Saalschützian hypergeometric series of unit argument p+1Fp(1) are presented. They generalize the Saalschützian summation formula for 3F2(1). Formulas for p=3,4,5 are obtained explicitly, and a recurrence relation is proved by means of which the corresponding formulas can also be derived for larger p. The Gaussian summation formula can be derived from the Saalschützian formula by a limiting process, and the same is true for the corresponding generalized formulas. By comparison with generalized Gaussian summation formulas obtained earlier in a different way, two identities for finite sums involving terminating 3F2(1) series are found. They depend on four or six independent parameters, respectively.

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Muhaemen, Miftahul, Mohammad Reza Faisal, Dodon Turianto Nugrahadi, Andi Farmadi, and Rudy Herteno. "IMPLEMENTATION TRANSFER LEARNING CONVOLUTIONAL NEURAL NETWORK FOR POTHOLE DETECTION ON DRONE VIDEO." Journal of Data Science and Software Engineering 1, no. 01 (March 23, 2020): 1–10. http://dx.doi.org/10.20527/jdsse.v1i01.3.

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Pothole is one of the problems that can cause harm to a person or a lot of people and can even cost lives. So a lot of research has been done to detect potholes, especially image-based. This research uses Unmanned Aerial Vehicle (UAV) to get aerial video dataset and train Convolutional Neural Network (CNN) with the dataset. However, instead of doing learning from the beginning, transfer learning can be used to train CNN to recognize the object of a pothole and measure the value of its performance and what the optimal frame rate is. Then the results of this study indicate that the CNN model, ssd_resnet_50_fpn_coco gets an average performance value of 48.90 mAP. And the optimal frame rate with the average highest performance value at a frame rate of 30FPS with a value of 49.43 mAP, followed by 1FPS with a value of 48.36 mAP . Keywords: Performance, Transfer Learning, Convolutional Neural Network, Pothole Detection, Aerial Video.

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Xu, Xiaofang, and Shujie Yun . "Two Types of the MacWilliams Identities of the Fp+uFp+...+uk-1Fp-Linear Codes." Journal of Applied Sciences 13, no. 24 (December 1, 2013): 5744–48. http://dx.doi.org/10.3923/jas.2013.5744.5748.

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Yaroshenko, A. O., and O. S. Shpychak. "Обґрунтування вибору носія для субстанції калини звичайної плодів екстракту рідкого у складі таблеток «Вібурнікор»." Ukrainian Journal of Military Medicine 4, no. 3 (September 30, 2023): 123–31. http://dx.doi.org/10.46847/ujmm.2023.3(4)-123.

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Мета. Обґрунтування вибору носія для субстанції калини звичайної плодів екстракту рідкого (КЗПЕР) у складі розроблюваних таблеток під умовною назвою «Вібурнікор» мембраностабілізувальної та кардіопротекторної. Матеріали та методи. У роботі були використані фізико‐хімічні, фармако-технологічні та статистичні методи аналізу. Як активний фармацевтичний інгредієнт було обрано калини звичайної плодів екстракт рідкий та дозволені до медичного застосування допоміжні речовини. Таблетки отримували методом прямого пресування. Дослідження впливу допоміжних речовин на фармако-технологічні характеристики, зокрема насипну густину до та після усадки, текучість, кут природного укосу та ін. проводили у відповідності з вимогами ДФУ 2-го видання Також вивчали залежність стійкості таблеток до вологи від природи допоміжних речовин у їх складі. Результати. Результати проведених випробувань свідчать про те, що висока питома поверхня та їх пориста структура зумовлюють використання досліджуваних кремнеземів марок Syloid® AL-1FP, Syloid 244 FP, Syloid XDP 3050 та Aeroperl® 300 у якості носіїв для отримання твердої лікарської форми. За одержаними результатами можна зробити висновок про те, що усі досліджувані зразки є перспективними речовинами для проведення подальших експериментальних досліджень при розробці складу таблеток на основі КЗПЕР, а отримані дані вказують на те, що більш об’ємним є порошок з носієм Syloid 244 FP, а меншу об’ємність має зразок із Syloid XDP 3050, який можна віднести до середньо об’ємних порошків. Висновки. На основі проведених фізико-хімічних та фармако-технологічних досліджень зразків сумішей з різними марками досліджуваних аморфних силікагелей, зокрема Syloid® AL-1FP, Syloid 244 FP, Syloid XDP 3050 та Aeroperl® 300 встановлено, що найбільш прийнятними носіями для нового вітчизняного лікарського засобу «Вібурнікор» у формі таблеток, розробленого на основі рослинної субстанції калини звичайної плодів екстракту рідкого методом прямого пресування є Syloid XDP 3050 та Syloid 244 FP, які між собою дещо відрізняються значеннями насипної густини в одержаних сумішах досліджуваних порошків.

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17

Chen, Kwang-Wu. "Clausen’s Series 3F2(1) with Integral Parameter Differences." Symmetry 13, no. 10 (September 25, 2021): 1783. http://dx.doi.org/10.3390/sym13101783.

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Ebisu and Iwassaki proved that there are three-term relations for 3F2(1) with a group symmetry of order 72. In this paper, we apply some specific three-term relations for 3F2(1) to partially answer the open problem raised by Miller and Paris in 2012. Given a known value 3F2((a,b,x),(c,x+1),1), if f−x is an integer, then we construct an algorithm to obtain 3F2((a,b,f),(c,f+n),1) in an explicit closed form, where n is a positive integer and a,b,c and f are arbitrary complex numbers. We also extend our results to evaluate some specific forms of p+1Fp(1), for any positive integer p≥2.

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Karp, Dmitrii B., and José L. López. "An extension of the multiple Erdélyi-Kober operator and representations of the generalized hypergeometric functions." Fractional Calculus and Applied Analysis 21, no. 5 (October 25, 2018): 1360–76. http://dx.doi.org/10.1515/fca-2018-0071.

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Abstract In this paper we investigate the extension of the multiple Erdélyi-Kober fractional integral operator of Kiryakova to arbitrary complex values of parameters by the way of regularization. The regularization involves derivatives of the function in question and the integration with respect to a kernel expressed in terms of special case of Meijer’s G-function. An action of the regularized multiple Erdélyi-Kober operator on some simple kernels leads to decomposition formulas for the generalized hypergeometric functions. In the ultimate section, we define an alternative regularization better suited for representing the Bessel type generalized hypergeometric function p−1Fp. A particular case of this regularization is then used to identify some new facts about the positivity and reality of zeros of this function.

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Qureshi, Mohd Idris, Junesang Choi, and Mohd Shaid Baboo. "Certain Identities Involving the General Kampé de Fériet Function and Srivastava’s General Triple Hypergeometric Series." Symmetry 14, no. 12 (November 25, 2022): 2502. http://dx.doi.org/10.3390/sym14122502.

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Due to the great success of hypergeometric functions of one variable, a number of hypergeometric functions of two or more variables have been introduced and explored. Among them, the Kampé de Fériet function and its generalizations have been actively researched and applied. The aim of this paper is to provide certain reduction, transformation and summation formulae for the general Kampé de Fériet function and Srivastava’s general triple hypergeometric series, where the parameters and the variables are suitably specified. The identities presented in the theorems and additional comparable outcomes are hoped to be supplied by the use of computer-aid programs, for example, Mathematica. Symmetry occurs naturally in p+1Fp, the Kampé de Fériet function and the Srivastava’s function F(3)[x,y,z], which are three of the most important functions discussed in this study.

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20

Zhang, Weina, Zhanjie Gao, Huimin Zhang, Hao Wei, Zejin Chen, Wenying Xue, and Zhenyu Liu. "The Influence of Heat Treatment on the Microstructure and Properties of a Cu-Bearing Ultra-Low Carbon Steel." Materials 17, no. 12 (June 20, 2024): 3031. http://dx.doi.org/10.3390/ma17123031.

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This study reveals the relationship between the Cu precipitates and mechanical properties of a Cu-baring ultra-low carbon steel after two-phase zone quenching and tempering at 923 K for 0.5–2.5 h. The tensile and microstructural properties were investigated as a function of heat treatment time. The contribution of the precipitation-strengthening mechanism to yield strength was calculated. The size, morphology, and distribution of the precipitated particles were observed using TEM. As the heat treatment time increased, the strength gradually decreased and then remained stable, and the elongation gradually increased and then remained stable. Additionally, the contributions of each strengthening mechanism to the yield strength under different heat treatments were 117, 107, 102, and 89 MPa, respectively. The size and quantity of the precipitates increased with the increase in heat treatment time. After tempering for more than 2 h, the precipitates continued to coarsen, but their quantity decreased. The precipitated Cu had a 3R structure with a length of approximately 17.1 nm and a width of approximately 9.7 nm, with no twinning inside. The stacking order was ABC/ABC. The stable Cu precipitation structure was FCC, maintaining a K-S orientation relationship 11¯1FCC Cu //(0 1 1) α, 1¯10FCC Cu//[11¯1] α.

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Li, Zhen, Rong Yuan, Miao Wang, Meiyan Hong, Li Zhu, Xiaofei Li, Ruixing Guo, Gang Wu, and Xinhua Zeng. "Development of the PARMS Marker of the Dominant Genic Male Sterility (DGMS) Line and Its Utilization in Rapeseed (Brassica napus L.) Breeding." Plants 11, no. 3 (February 3, 2022): 421. http://dx.doi.org/10.3390/plants11030421.

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The 8029AB line is a dominant genic male sterility (DGMS) two-type line in Brassica napus L., which can be used in a three-line approach for the seed production of rapeseed hybrids. Genetic analyses have demonstrated that the sterility of 8029A is controlled by a single dominant nuclear gene (BnMS5e) interacting with one recessive gene (BnMS5c). Six pairs of penta-primer amplification refractory mutation system (PARMS) markers were designed according to the sequence of BnMS5a, BnMS5c and BnMS5e. Two pairs of these PARMS markers were successfully identified and validated. The PARMS markers MS5-1Fc/MS5-1Ft/MS5-1R12 could distinguish BnMS5c from BnMS5a/BnMS5e, and the PARMS markers MS5-2Ft/MS5-2Fa/MS5-1R12 could genotype BnMS5a and BnMS5c/BnMS5e. The combination of these two pairs of PARMS markers could be used to identify the presence or absence of BnMS5a/BnMS5c/BnMS5e effectively. Consequently, marker-assisted selection can be carried out in the early generation to shorten the breeding period and improve the breeding efficiency.

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Günther, Christian, and Kai-Uwe Schmidt. "Lq Norms of Fekete and Related Polynomials." Canadian Journal of Mathematics 69, no. 4 (August 1, 2017): 807–25. http://dx.doi.org/10.4153/cjm-2016-023-4.

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AbstractA Littlewood polynomial is a polynomial in ℂ[z] having all of its coefficients in {−1, 1}. There are various old unsolved problems, mostly due to Littlewood and Erdos, that ask for Littlewood polynomials that provide a good approximation to a function that is constant on the complex unit circle, and in particular have small Lq normon the complex unit circle. We consider the Fekete polynomialswhere p is an odd prime and (· |p) is the Legendre symbol (so that z-1fp(z) is a Littlewood polynomial). We give explicit and recursive formulas for the limit of the ratio of Lq and L2 norm of fp when q is an even positive integer and p → ∞. To our knowledge, these are the first results that give these limiting values for specific sequences of nontrivial Littlewood polynomials and infinitely many q. Similar results are given for polynomials obtained by cyclically permuting the coefficients of Fekete polynomials and for Littlewood polynomials whose coefficients are obtained from additive characters of finite fields. These results vastly generalise earlier results on the L4 norm of these polynomials.

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Dem??ralp, Metin, and Gülşen Taşkin. "Relations Between the Matrix Algebraic Factorized Type Solutions at Different Singular Points for Generalized Hypergeometric Functions of Typep+1Fp." Applied Numerical Analysis & Computational Mathematics 2, no. 2 (August 2005): 227–37. http://dx.doi.org/10.1002/anac.200410037.

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Neto, M., A. Maduro, A. Saraiva, J. A. P. Da Silva, T. Santiago, and M. J. Salvador. "POS1297 PULMONARY INVOLVEMENT IN VERY EARLY SYSTEMIC SCLEROSIS (VEDOSS): REPORT FROM A SINGLE CENTER." Annals of the Rheumatic Diseases 82, Suppl 1 (May 30, 2023): 995.2–996. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4056.

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BackgroundPrevious work has described interstitial lung disease (ILD) in very early systemic sclerosis (VEDOSS)[1], but its progression over time is unknown. This can contribute decisively to the delineation of screening and monitoring strategies.ObjectivesTo evaluate the prevalence of ILD and its course in a cohort of patients who persist in a VEDOSS state, followed in a tertiary systemic sclerosis unit, over 10 years.MethodsRetrospective observational study of patients persistently fulfilling VEDOSS criteria[2], with sequential measurement of diffusing lung capacity for carbon monoxide (DLCO) and forced vital capacity (FVC), at 0, 1, 5 and 10 years. Chest CT at baseline was considered, when available. A DLCO or FVC <80% of predicted values was considered indicative of lung involvement[1]. A decline of FVC or DLCO of ≥5% and ≥15% in any of the time intervals was considered clinically relevant[3].Demographic, clinical, and immunological variables at baseline were taken as potential independent variables, including age, gender, disease duration, arthritis, capillaroscopy pattern, and autoantibody profile. Pearson χ2 test, Fisher’s exact test or independent sample t-test were used for independent measures as appropriate. Repeated-measures ANOVA was used to compare variables over time.Results30 patients (86,7% women, mean baseline age 46,9±12,87 yrs) were included; median time from first symptoms to diagnosis was 4,4 (IQR 7,6) yrs.At baseline, 4 patients had mildly decreased DLCO values (60-79% of predicted), results being normal in all remaining persons (Table 1). During the first year of follow-up, a ≥5% decrease in FVC was observed in 6/30 patients (20%) and a DLCO decrease of ≥15% in 2/30 (6,7%). There was a non-significant trend for a higher probability of FVC and DLCO decrease in males vs females (M:50,0% vs F:15,3%F and M:25,0% vs F3,8%, respectively). None of the other variables was associated with FVC or DLCO decrease.Pulmonary tests were available for the 25 and 5 patients who reached 5 and 10 years of follow-up. No association was found between any of the clinical variables and significant change of FVC and DLCO at these time points. Mean values of FVC and DLCO consistently declined overtime, without reaching statistical significance (Table 1). The incidence of significant change in FVC and DLCO between contiguous evaluations is represented in Figure 1. There is a non-significant trend for a higher probability of decline as follow-up time increased.Table 1FVC and DLCO measurements at baseline and at 1, 5 and 10 yearsBaseline(n=30)1 year(n=30)5 years(n=25)10 years(n=5)p-valueFVC(% predicted), mean ± SD112,7±15,9111,5±15,5109,6±18,4110,8±26,1NSFVC <80% predicted,% (n)0 (0)0 (0)4,0 (1)20,0 (1)NSDLCO(% predicted), mean ± SD96,6±14,197,8±16,190,7±13,985,7±10,6NSDLCO <80% predicted, % (n)13,3 (4)16,7 (5)20,0 (5)20,0 (1)NSFigure 1FVC and DLCO change at 1, 5 and 10 yearsConclusionOur study provides data on the long-term assessment of FVC and DLCO in VEDOSS patients. There was a relevant decrease in FVC during the first year in 20% of the patients, and 20% had impaired DLCO (<80%) at 5 years, which suggests that a subset of patients who persist in VEDOSS state overtime still endure significant subclinical pulmonary involvement.References[1]Valentini G, Vettori S, Cuomo G, et al. Early systemic sclerosis: short-term disease evolution and factors predicting the development of new manifestations of organ involvement. Arthritis Res Ther 2012; 14: R188. 20120817. DOI: 10.1186/ar4019.[2]Avouac J, Fransen J, Walker UA, et al. Preliminary criteria for the very early diagnosis of systemic sclerosis: results of a Delphi Consensus Study from EULAR Scleroderma Trials and Research Group. Ann Rheum Dis 2011; 70: 476-481. 20101115. DOI: 10.1136/ard.2010.136929.[3]Hoffmann-Vold AM, Allanore Y, Alves M, et al. Progressive interstitial lung disease in patients with systemic sclerosis-associated interstitial lung disease in the EUSTAR database. Ann Rheum Dis 2021; 80: 219-227. 20200928. DOI: 10.1136/annrheumdis-2020-217455.Acknowledgements:NIL.Disclosure of InterestsNone Declared.

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Kotovuori, Annika, Tiina Pessa-Morikawa, Pekka Kotovuori, Pekka Nortamo, and Carl G. Gahmberg. "ICAM-2 and a Peptide from Its Binding Domain Are Efficient Activators of Leukocyte Adhesion and Integrin Affinity." Journal of Immunology 162, no. 11 (June 1, 1999): 6613–20. http://dx.doi.org/10.4049/jimmunol.162.11.6613.

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Abstract Cell adhesion mediated by the CD11/CD18 integrins and their ligands, the ICAMs, is required for many leukocyte functions. In resting cells the integrins are nonadhesive, but when activated they become adhesive for their ligands. Previous findings have shown that a peptide derived from the first Ig domain of ICAM-2 (P1) binds to LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) and activates leukocyte aggregation. Because its mechanism of action has remained poorly understood, we have now studied the peptide-induced ligand binding in detail. Here we show that P1 was able to induce CD11/CD18-dependent adhesion of human T lymphocytes to immobilized, purified ICAM-1, -2, and -3. The optimal peptide concentration was 150 μg/ml, whereas concentrations higher than 400 μg/ml did not have any stimulatory effect. The increase in adhesion was detectable within 10 min of treatment with the peptide; it was dependent on energy, divalent cations, temperature, and an intact cytoskeleton but was unaffected by protein kinase C and protein tyrosine kinase inhibitors. Peptide treatment resulted in strong stimulation of the binding of soluble, recombinant ICAMs to T lymphocytes, showing that the integrin affinity toward its ligands was increased. Importantly, soluble ICAM-2Fc was also able to induce T lymphocyte adhesion to purified ICAM-1, -2, and -3, and it was a more potent stimulatory molecule than ICAM-1Fc or ICAM-3Fc.

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Porgolestani, Mehdi, Gholamreza Motalleb, Ahmad Rashki, and Leila Vafadar Ghasemi. "Frequency of Aminoglycoside Resistance Genes in Clinical Isolates of Pseudomonas aeruginosa from Sistan, Iran." International Journal of Basic Science in Medicine 8, no. 4 (December 31, 2023): 161–66. http://dx.doi.org/10.34172/ijbsm.46643.

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<strong data-sider-select-id="601e8ebc-948d-4607-8120-ea3b3b749171">Introduction: Pseudomonas aeruginosa is a prevalent healthcare-acquired infection. It is a global concern due to its potential for multidrug resistance and for posing significant challenges to healthcare providers. Two critical processes that lead to aminoglycoside resistance are the methylation of 16S ribosomal RNA (16S rRNA) and aminoglycoside-modifying enzymes (AMEs). Aminoglycosides are potent antimicrobial medicines often used to eliminate pseudomonas infections efficiently. This research aimed to assess the frequency of the occurrence of 16S rRNA methylase and AME genes in clinical isolates of P. aeruginosa in Sistan, Iran. <strong data-sider-select-id="8fe3043e-bb8a-4c05-8189-cf39ae993d24">Methods: A total of 60 clinical isolates of P. aeruginosa were collected. The isolates were identified from July 1, 2020, to May 28, 2022. A multiplex polymerase chain reaction (PCR) was carried out to amplify the 16S rRNA methylase genes (armA and rmtA) and AME genes [Aph(3′)- Ib, Aph(6′)-VI, aadA1, aadB, and aac] in clinical isolates of P. aeruginosa in Sistan, Iran. <strong data-sider-select-id="8b7f3529-1fdc-4bdd-ac68-9ef8ec095249">Results: The most prevalent AME gene was aadB, which was present in 48.33% of the isolates (29/60). The least prevalent genes were aac, aadA1, and Aph(3′)-Ib with frequencies of 6 (10%), 6 (10%), and 7 (11.66%), respectively. It was found that 85% (51/60) of the P. aeruginosa isolated were resistant to gentamicin, 65% (39/60) were resistant to amikacin, and 23.33% (14/60) were resistant to tobramycin. <strong data-sider-select-id="435ca255-50c7-4742-a900-e3d601030023">Conclusion: Overall, this study determined that aadB was the most prevalent AME gene. In contrast, the genes aac, aadA1, and Aph(3′)-Ib had the lowest occurrence in clinical isolates of P. aeruginosa from southeastern Iran.

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Hogarth, P. M., E. Witort, M. D. Hulett, C. Bonnerot, J. Even, W. H. Fridman, and I. F. McKenzie. "Structure of the mouse beta Fc gamma receptor II gene." Journal of Immunology 146, no. 1 (January 1, 1991): 369–76. http://dx.doi.org/10.4049/jimmunol.146.1.369.

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Abstract We have isolated and deduced the structure of the beta Fc gamma RII gene from the mouse. This gene spans approximately 18 kb of DNA; the structure and nucleotide sequence has been determined and potential regulatory sites identified. This gene is composed of 10 exons that give rise to the beta 1 and beta 2 Fc gamma RII cDNA. Four exons encode the 5' untranslated region and leader sequence, one exon for each Ig-binding domain and membrane-spanning region and three exons encoding the cytoplasmic tail and 3' untranslated region. Analysis of the gene structure indicated that the beta 1Fc gamma RII and beta 2Fc gamma RII arise by differential mRNA splicing when a single 141-bp exon (exon 8) is alternately spliced to give rise to these isoforms. Sequence analysis of 2 kbp upstream of the transcription start site indicated the presence of regulatory elements, including three binding sites for the transcription factor Sp1, and Ap-4 binding site, a tandem glucocorticoid response element, and an overlapping tandem repeat. Furthermore, as in the Thy-1 gene, no CAT or TATA consensus sequences were observed. In addition, sites of methylation that regulate expression of this gene were also located at the 5' end of the gene and within several introns. A large intron located between exons 4 and 5 also contained a series of purine/pyrimidine-rich regions and a potential enhancer sequence.

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Chen, Yeng-Nan, Jung-Tung Hung, Fan-Dan Jan, Yung-Yu Su, Jih-Ru Hwu, Alice L. Yu, Avijit K. Adak, and Chun-Cheng Lin. "Diversity-Oriented Synthesis of a Molecular Library of Immunomodulatory α-Galactosylceramides with Fluorous-Tag-Assisted Purification and Evaluation of Their Bioactivities in Regard to IL-2 Secretion." International Journal of Molecular Sciences 23, no. 21 (November 2, 2022): 13403. http://dx.doi.org/10.3390/ijms232113403.

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Structural variants of α-galactosylceramide (α-GalCer) that stimulate invariant natural killer T (iNKT) cells constitute an emerging class of immunomodulatory agents in development for numerous biological applications. Variations in lipid chain length and/or fatty acids in these glycoceramides selectively trigger specific pro-inflammatory responses. Studies that would link a specific function to a structurally distinct α-GalCer rely heavily on the availability of homogeneous and pure materials. To address this need, we report herein a general route to the diversification of the ceramide portion of α-GalCer glycolipids. Our convergent synthesis commences from common building blocks and relies on the Julia–Kocienski olefination as a key step. A cleavable fluorous tag is introduced at the non-reducing end of the sugar that facilitates quick purification of products by standard fluorous solid-phase extraction. The strategy enabled the rapid generation of a focused library of 61 α-GalCer analogs by efficiently assembling various lipids and fatty acids. Furthermore, when compared against parent α-GalCer in murine cells, many of these glycolipid variants were found to have iNKT cell stimulating activity similar to or greater than KRN7000. ELISA assaying indicated that glycolipids carrying short fatty N-acyl chains (1fc and 1ga), an unsubstituted (1fh and 1fi) or CF3-substituted phenyl ring at the lipid tail, and a flexible, shorter fatty acyl chain with an aromatic ring (1ge, 1gf, and 1gg) strongly affected the activation of iNKT cells by the glycolipid-loaded antigen-presenting molecule, CD1d. This indicates that the method may benefit the design of structural modifications to potent iNKT cell-binding glycolipids.

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Del Giglio, A., J. F. Pinto, F. A. Fonseca, S. R. Marsicano, P. O. Delgado, P. G. Coelho, A. L. Sant’Anna, and P. Maeda. "Chemotherapy induces microssatelite instability (MIS) in plasma free DNA (pfDNA), peripheral blood mononuclear fraction (PBMNF) cells, and urine free DNA (ufDNA) of breast cancer (BC) patients as well as in normal PBMNF cells in vitro in the absence of amifostine (A)." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): e11505-e11505. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e11505.

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e11505 Background: We have previously shown that alkylating agent based chemotherapy regimens (AQT) could induce MIS in the PBMNF of BC patients in parallel to a decrease in the expression of the protein hMSH2 in these cells (Fonseca et al., 2005, Breast Cancer Res, 7, R28–32). Since plasma DNA derives mainly from tumor cells, we wanted to know if chemotherapy would also produce MIS in tumor DNA and if this phenomenon could be reproduced in vitro. Methods: 33 previously untreated female BC patients with a mean age of 51 years received AQT(16 ACT;3FAC;2 TAC;1FEC;10AC). Samples from 3 additional patients who received Fulvestrant only as neoadjuvant therapy were also included. Blood (pfDNA and PBMNNF) and urine (ufDNA) were evaluated at time 0,3 and 6 months with 6 MIS markers (BAT40,BAT26, MR2,TP53 PCR15.1, APC and ALU). Levels of fpDNA and fuDNA were measured by spectrophotometry. We incubated in vitro cultures of MCF- 7 cells and PBMNF cells with M at a dose of 0.7μg/ml for 30 minutes with and without A at 20% of the M dose and evaluated serially for 48 hours for MIS and hMH2 expression by immunohistochemistry. Results: We observed at least one MIS event in the PBMNF, fpDNA or fuDNA in 87%, 80% and 80% of the patients, respectively, mainly in BAT40 and BAT 26 markers. There was only 14.74% of concordance of MIS alterations between PBMNF and fpDNA and 8. 42% between fpDNA and fuDNA. Patients receiving Hormones also exhibited MIS. Interestingly, fpDNA levels increased significantly in patients with measurable disease who responded to therapy (47.4 ± 13.34 vs 14.37± 5.32; p = 0.021). In vitro, incubating MCF-7 cells and normal PBMNF cells with M ±A, we observed that we could induce MIS in both MCF-7 cells and normal PBMNF cells but A prevented MIS only in normal PBMNF cells. In normal PBMNF cells without A that sustained MIS there was a significantly decreased percentage of cells expressing hMSH2 ( 96% vs 57% p < 0.001). Conclusions: We conclude that Chemotherapy as well as Fulvestran can induce MIS in normal and malignant cells and that in vitro these effects could be reproduced by treatment with M and prevented in normal cells by A. No significant financial relationships to disclose.

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30

"Urgent Coronary Revascularization In A Familial Polycystic Kidney Disease Patient With Unstable Angina Pectoris." Internet Journal of Thoracic and Cardiovascular Surgery 7, no. 1 (2005). http://dx.doi.org/10.5580/1f0c.

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31

"Hepatitis A Vaccination: Is It Necessary For Thai Adults?" Internet Journal of Asthma, Allergy and Immunology 3, no. 2 (2005). http://dx.doi.org/10.5580/1f1c.

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32

"Choosing An Insulin Analogue Regime." Internet Journal of Geriatrics and Gerontology 5, no. 2 (2010). http://dx.doi.org/10.5580/1f2c.

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33

"A Novel Technique Of Interlocking Nailing In Compound Fractures Of The Tibia Without Image Intensifier By Nail Overlapping Technique." Internet Journal of Orthopedic Surgery 10, no. 2 (2008). http://dx.doi.org/10.5580/1f3c.

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34

"Concurrent giardiasis and amoebiasis infections in Nigerian children diagnosed with Plasmodium falciparum malaria: prevalence and pathophysiological implications." Internet Journal of Tropical Medicine 6, no. 1 (2009). http://dx.doi.org/10.5580/1f4c.

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35

"The Role Of Diuretics In The Intensive Care Unit: A Review." Internet Journal of Emergency and Intensive Care Medicine 8, no. 2 (2005). http://dx.doi.org/10.5580/1f5c.

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36

"Reflections of "The Flood": Will the Rain Never End?" Internet Journal of Rescue and Disaster Medicine 3, no. 1 (2002). http://dx.doi.org/10.5580/1f6c.

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37

"Fertiloscopy – An Overview." Internet Journal of Gynecology and Obstetrics 12, no. 2 (2010). http://dx.doi.org/10.5580/1f7c.

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38

"Prevalence Of Bovine Fasciolosis And Economic Importance Due To Liver Condemnation At Kombolcha Industrial Abattoir, Ethiopia." Internet Journal of Veterinary Medicine 8, no. 2 (2010). http://dx.doi.org/10.5580/1f8c.

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39

"Evaluation Of Nutritional Status By Different Parameters And To Predict Spontaneous Closure, Morbidity And Mortality In Patients With Enterocutaneous Fistulas: A Study Of 92 Cases." Internet Journal of Nutrition and Wellness 6, no. 1 (2008). http://dx.doi.org/10.5580/1f9c.

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40

"Comparison of the sniffing position with simple head extension for laryngoscopic view in elective surgical patients." Internet Journal of Anesthesiology 17, no. 1 (2008). http://dx.doi.org/10.5580/1fac.

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"Protection From Unilateral Renal Ischemia/Reperfusion Induced Injury In The Non-Ischemic Distant Kidney With Fenoldopam." Internet Journal of Emergency and Intensive Care Medicine 10, no. 1 (2007). http://dx.doi.org/10.5580/1fbc.

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42

"The Relationship Between Maternal Serum Visfatin Level And Hypertensive Disorders of Pregnancy." Internet Journal of Gynecology and Obstetrics 15, no. 1 (2011). http://dx.doi.org/10.5580/1fcc.

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43

"Risk Factors For Hepatitis B Virus Transmission In Nigerians: A Case-Control Study." Internet Journal of Gastroenterology 10, no. 1 (2010). http://dx.doi.org/10.5580/1fdc.

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44

"Estimation Of CA-125 Level In First Trimester Threatened Abortion." Internet Journal of Gynecology and Obstetrics 12, no. 2 (2010). http://dx.doi.org/10.5580/1fec.

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45

"Ultrasonography Of The Optic Nerve Sheath Suggested Elevated Intracranial Pressure In Epilepsy: Case Report." Internet Journal of Anesthesiology 26, no. 1 (2010). http://dx.doi.org/10.5580/1ffc.

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46

"Malignant hemangiopericytoma of the retroperitoneum: A Case Report And Review Of Literature." Internet Journal of Surgery 17, no. 1 (2008). http://dx.doi.org/10.5580/1fc.

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47

Hara, Yusuke, Aya Ichiraku, Tomoki Matsuda, Ayuko Sakane, Takuya Sasaki, Takeharu Nagai, and Kazuki Horikawa. "High-affinity tuning of single fluorescent protein-type indicators by flexible linker length optimization in topology mutant." Communications Biology 7, no. 1 (June 8, 2024). http://dx.doi.org/10.1038/s42003-024-06394-0.

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AbstractGenetically encoded Ca2+ indicators (GECIs) are versatile for live imaging of cellular activities. Besides the brightness and dynamic range of signal change of GECIs, Ca2+ affinity is another critical parameter for successful Ca2+ imaging, as the concentration range of Ca2+ dynamics differs from low nanomolar to sub-millimolar depending on the celltype and organism. However, ultrahigh-affinity GECIs, particularly the single fluorescent protein (1FP)-type, are lacking. Here, we report a simple strategy that increases Ca2+ affinity through the linker length optimization in topology mutants of existing 1FP-type GECIs. The resulting ultrahigh-affinity GECIs, CaMPARI-nano, BGECO-nano, and RCaMP-nano (Kd = 17–25 nM), enable unique biological applications, including the detection of low nanomolar Ca2+ dynamics, highlighting active signaling cells, and multi-functional imaging with other second messengers. The linker length optimization in topology mutants could be applied to other 1FP-type indicators of glutamate and potassium, rendering it a widely applicable technique for modulating indicator affinity.

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48

Zhang, Y. H., P. Zhang, X. H. Zhou, M. Wang, Yu A. Litvinov, H. S. Xu, X. Xu, et al. "Isochronous mass measurements of Tz=−1fp -shell nuclei from projectile fragmentation of Ni58." Physical Review C 98, no. 1 (July 18, 2018). http://dx.doi.org/10.1103/physrevc.98.014319.

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49

Pfäffli, Roland. "Rezension: Stockwerkeigentum und Grundbuch." Jusletter, no. 1158 (2023). http://dx.doi.org/10.38023/176a8215-1fbc-4392-98c8-f38fa5387d46.

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Schröder, Markus. "Datenschutzrechtliche Stellung von Freelancern und Consultants." Jusletter-IT, no. 27-April-2023 (2023). http://dx.doi.org/10.38023/71262f32-1fec-46f4-8969-b60463d6e591.

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