Relevant bibliographies by topics / 172/.42

Academic literature on the topic '172/.42'

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Published: 25 July 2024
Last updated: 26 July 2024

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Journal articles on the topic "172/.42"

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Samuthpongtorn, Chatpol, Long H. Nguyen, Olivia I. Okereke, Dong D. Wang, Mingyang Song, Andrew T. Chan, and Raaj S. Mehta. "Consumption of Ultraprocessed Food and Risk of Depression." JAMA Network Open 6, no. 9 (September 20, 2023): e2334770. http://dx.doi.org/10.1001/jamanetworkopen.2023.34770.

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Khan, Yasmee, Arati Lalchandani, and AC Gupta. "A Study Of Prevalence Of Chronic Kidney Disease In Patients With Metabolic Syndrome In Urban Population Attending A Tertiary Care Center In India: A Hospital-Based Prospective Cross-Sectional Observational Study." Recent Advances in Biology and Medicine 8, no. 4 (October 27, 2022): 1–7. http://dx.doi.org/10.18639/rabm.2022.9800027.

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The study aims to determine the prevalence of Chronic Kidney Disease (CKD) and its risk factors in patients with Metabolic Syndrome in a tertiary care center in India. It was a hospital-based prospective observational study where NCEP ATP III CRITERIA was used to diagnose patients with Metabolic Syndrome, and CKD was defined according to KDIGO Guidelines. Out of 172 patients with Metabolic Syndrome, CKD was seen in 52 patients, of which 29 were males and 23 were females, so the prevalence of CKD in Metabolic Syndrome patients was about 30.23%. (52/172) P Value = 0.0000204. In our study, the prevalence of hyperglycemia in CKD patients with Metabolic Syndrome was 24.41% (42/172) P Value = .0011. The prevalence of obesity was 19.18% (33/172) P Value = .00844. The prevalence of hypertension was 28.48% (49/172) P Value = 2.72. The prevalence of hypertriglyceridemia was 26.12% (45\172) P Value = 0.000002086. The prevalence of hyperglycemia, obesity, and hypertriglyceridemia was significantly high in males. The prevalence of CKD in Metabolic Syndrome is 30.23% which is quite high, and since the prevalence of CKD is rising in India, we need more studies to look into this aspect of Metabolic Syndrome.
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Albano, Domenico, Carmelo Messina, Angelo Gambino, Martina Gurgitano, Carmelo Sciabica, Giordano Remo Oliveira Pavan, Salvatore Gitto, and Luca Maria Sconfienza. "Segmented lordotic angles to assess lumbosacral transitional vertebra on EOS." European Spine Journal 29, no. 10 (August 11, 2020): 2470–76. http://dx.doi.org/10.1007/s00586-020-06565-7.

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Abstract Purpose To test the vertical posterior vertebral angles (VPVA) of the most caudal lumbar segments measured on EOS to identify and classify the lumbosacral transitional vertebra (LSTV). Methods We reviewed the EOS examinations of 906 patients to measure the VPVA at the most caudal lumbar segment (cVPVA) and at the immediately proximal segment (pVPVA), with dVPVA being the result of their difference. Mann–Whitney, Chi-square, and ROC curve statistics were used. Results 172/906 patients (19%) had LSTV (112 females, mean age: 43 ± 21 years), and 89/172 had type I LSTV (52%), 42/172 type II (24%), 33/172 type III (19%), and 8/172 type IV (5%). The cVPVA and dVPVA in non-articulated patients were significantly higher than those of patients with LSTV, patients with only accessory articulations, and patients with only bony fusion (all p < .001). The cVPVA and dVPVA in L5 sacralization were significantly higher than in S1 lumbarization (p < .001). The following optimal cutoff was found: cVPVA of 28.2° (AUC = 0.797) and dVPVA of 11.1° (AUC = 0.782) to identify LSTV; cVPVA of 28.2° (AUC = 0.665) and dVPVA of 8° (AUC = 0.718) to identify type II LSTV; cVPVA of 25.5° (AUC = 0.797) and dVPVA of − 7.5° (AUC = 0.831) to identify type III–IV LSTV; cVPVA of 20.4° (AUC = 0.693) and dVPVA of − 1.8° (AUC = 0.665) to differentiate type II from III–IV LSTV; cVPVA of 17.9° (AUC = 0.741) and dVPVA of − 4.5° (AUC = 0.774) to differentiate L5 sacralization from S1 lumbarization. Conclusion The cVPVA and dVPVA measured on EOS showed good diagnostic performance to identify LSTV, to correctly classify it, and to differentiate L5 sacralization from S1 lumbarization.
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Akhtar, Kashif, Weiyu Wang, Ivica Djalovic, P. V. Vara Prasad, Guangxin Ren, Noor ul Ain, Muhammad Riaz, Yongzhong Feng, Gaihe Yang, and Ronghui Wen. "Combining Straw Mulch with Nitrogen Fertilizer Improves Soil and Plant Physio-Chemical Attributes, Physiology, and Yield of Maize in the Semi-Arid Region of China." Plants 12, no. 18 (September 19, 2023): 3308. http://dx.doi.org/10.3390/plants12183308.

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Mulching and nitrogen (N) fertilization are the main drivers for sustainable crop production. The sole use of nitrogen fertilizer threatened both the physiology and production of maize in rain-fed areas. Therefore, we proposed that wheat straw mulching with N fertilization would increase maize yield by improving soil fertility, physiology, and nitrogen use efficiency. A two-year field study evaluated the effects of CK (control), N (nitrogen application at 172 kg ha−1), HS (half wheat straw mulch, 2500 kg ha−1), HS+N (half wheat straw, 2500 kg ha−1 plus 172 kg N ha−1), FS (full wheat straw, 5000 kg ha−1), and FS+N (full wheat straw, 5000 kg ha−1 plus 172 kg N ha−1) on maize growth, physiology, and biochemistry. Compared with the control, the FS+N treatment resulted in the increase of 56% photosynthetic efficiency, 9.6% nitrogen use efficiency, 60% nitrogen uptake, 80% soluble sugar, 59% starches, 48% biomass, and 29% grain yield of maize. In addition, the FS+N regime increased 47%, 42%, and 106% of soil organic carbon and available P and N content in comparison with the control. Maize grain and biomass yields were positively correlated with N uptake, photosynthesis, soil organic carbon, and soil available N and P contents. Conclusively, the use of wheat straw at 5000 kg ha−1, along with 172 kg N ha−1, is a promising option for building a sustainable wheat–maize cropping system to achieve optimal crop yield and improved plant and soil health in a semi-arid region of China.
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Bruchhaus Steinert, Helke. "Was hat die Liebe in der Paartherapie zu suchen?" Familiendynamik 42, no. 03 (July 2017): 172–81. http://dx.doi.org/10.21706/fd-42-3-172.

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Hanamori, T., K. Hirota, and N. Ishiko. "Receptive fields and gustatory responsiveness of frog glossopharyngeal nerve. A single fiber analysis." Journal of General Physiology 95, no. 6 (June 1, 1990): 1159–82. http://dx.doi.org/10.1085/jgp.95.6.1159.

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Receptive fields and responsiveness of single fibers of the glossopharyngeal (IXth) nerve were investigated using electrical, gustatory (NaCl, quinine HCl, acetic acid, water, sucrose, and CaCl2), thermal, and mechanical stimulation of the single fungiform papillae distributed on the dorsal tongue surface in frogs. 172 single fibers were isolated. 58% of these fibers (99/172) were responsive to at least one of the gustatory stimuli (taste fibers), and the remaining 42% (73/172) were responsive only to touch (touch fibers). The number of papillae innervated by a single fiber (receptive field) was between 1 and 17 for taste fibers and between 1 and 10 for touch fibers. The mean receptive field of taste fibers (X = 6.6, n = 99) was significantly larger than that of touch fibers (X = 3.6, n = 73) (two-tailed t test, P less than 0.001). In experiments with natural stimulation of single fungiform papillae, it was found that every branch of a single fiber has a similar responsiveness. Taste fibers were classified into 14 types (Type N, Q, A, NA, NCa, NCaA, NCaW, NCaAW, NCaWS, NQ, NQA, NQAS, NQWarm, Multiple) on the basis of their responses to gustatory and thermal stimuli. The time course of the response in taste fibers was found to be characteristic of their types. For example, the fibers belonging to Type NQA showed phasic responses, those in Type NCa showed tonic responses, etc. These results indicate that there are several groups of fibers in the frog IXth nerve and that every branch of an individual fiber has a similar responsiveness to the parent fiber.
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Iannone, Giovanni, Clelia Tripaldi, Antonino Chindemi, Lorenzo Piscitelli, Antonio Mastrorocco, Silvano Palazzo, and Luigi Esposito. "Long-Term Neuropsychological Outcome in Preterm Twins." Scientific World JOURNAL 6 (2006): 899–907. http://dx.doi.org/10.1100/tsw.2006.175.

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Few long-term studies have yet described neuropsychological outcome in preterm twins. Our aim was to assess, by long-term evaluation, neuropsychological outcome in preterm twins in order to define a correct follow-up program. Our study was a cohort one, with an index and a comparison group. Neonatal medical records of all preterm newborns admitted to our centre between 1991 and 1997 were reviewed and selected patients were recalled. The sample population included two matched groups of children aged 6—12 years, 86 twins and 86 singletons, submitted to paediatric, neurological, psychological, and ophthalmological examinations. Inclusion criteria were twin pregnancy and gestational age 27—36 weeks for index group; same gestational age, but single pregnancy, for the comparison group. All children underwent paediatric and neuropsychiatric examinations, cognitive assessment, and psychological evaluation by standardized tests for screening of learning specific disorders and language difficulties, and finally, ophthalmological examination. In order to study their role in predicting neuropsychological outcome, we examined some perinatal prognostic factors by statistical analysis. Unfavourable neuropsychological outcome was observed in 55/172 (32%) children, with different prevalence in the two groups, 42/172 (24%) in twins and 13/172 (8%) in singletons. Statistical analysis performed for examined prognostic factors showed significant differences in neuropsychological outcome with regard only to gestational age < 32 weeks, low birth weight, intraventricular haemorrhage, and periventricular leukomalacia. The incidence of neuropsychological diseases in the two groups showed significant difference about language and learning difficulties. Our data suggest that preterm twins represent a particular high-risk category of premature babies, mostly regarding the risk of so-called “minimal brain dysfunction”, so a careful follow-up is recommended.
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Lorenzo-González, Cristina, Elena Atienza-Sánchez, David Reyes-Umpierrez, Priyathama Vellanki, Georgia M. Davis, Francisco J. Pasquel, Saumeth Cardona, Maya Fayfman, Limin Peng, and Guillermo E. Umpierrez. "SAFETY AND EFFICACY OF DPP-4 INHIBITORS FOR THE MANAGEMENT OF HOSPITALIZED GENERAL MEDICINE AND SURGERY PATIENTS WITH TYPE 2 DIABETES." Endocrine Practice 26, no. 7 (July 2020): 722–28. http://dx.doi.org/10.4158/ep-2019-0481.

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Objective: DPP-4 inhibitors (DPP-4i) have been shown to be effective for the management of inpatient diabetes. We report pooled data from 3 prospective studies using DPP-4i in general medicine and surgery patients with type 2 diabetes (T2D). Methods: We combined data from 3 randomized studies comparing DPP-4i alone or in combination with basal insulin or a basal-bolus insulin regimen. Medicine (n = 266) and surgery (n = 319) patients admitted with a blood glucose (BG) between 140 and 400 mg/dL, treated with diet, oral agents, or low-dose insulin therapy were included. Patients received DPP-4i alone (n = 144), DPP-4i plus basal insulin (n = 158) or basal-bolus regimen (n = 283). All groups received correctional doses with rapid-acting insulin for BG >140 mg/dL. The primary endpoint was differences in mean daily BG between groups. Secondary endpoints included differences in hypoglycemia and hospital complications. Results: There were no differences in mean hospital daily BG among patients treated with DPP-4i alone (170 ± 37 mg/dL), DPP-4i plus basal (172 ± 42 mg/dL), or basalbolus (172 ± 43 mg/dL), P = .94; or in the percentage of BG readings within target of 70 to 180 mg/dL (63 ± 32%, 60 ± 31%, and 64 ± 28%, respectively; P = .42). There were no differences in length of stay or complications, but hypoglycemia was less common with DPP-4i alone (2%) compared to DPP-4i plus basal (9%) and basal-bolus (10%); P = .004. Conclusion: Treatment with DPP-4i alone or in combination with basal insulin is effective and results in a lower incidence of hypoglycemia compared to a basal-bolus insulin regimen in general medicine and surgery patients with T2D. Abbreviations: BG = blood glucose; BMI = body mass index; CI = confidence interval; DPP-4i = dipeptidyl peptidase-4 inhibitors; HbA1c = hemoglobin A1c; OR = odds ratio; T2D = type 2 diabetes
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Sambyalova, A. Yu, T. A. Bairova, T. L. Manaenkova, A. V. Belskikh, Yu K. Plotnikova, and L. V. Rychkov. "Virological failure of antiretroviral therapy and associated social and clinical factors in children and adolescents living with HIV." Journal Infectology 14, no. 5 (December 31, 2022): 51–59. http://dx.doi.org/10.22625/2072-6732-2022-14-5-51-59.

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According to the World Health Organization, sustained virological suppression of 90 % should be achieved among children and adolescents living with HIV / AIDS, which makes it important to assess the prevalence of virological failure of antiretroviral therapy. The aim of this study was to determine the prevalence of virological failure and the clinical factors associated with it, as well as therapeutic drug monitoring in groups divided by the viral load level among children and adolescents with HIV. Materials and Methods: A retrospective analysis of the medical records of 184 children and adolescents receiving antiretroviral therapy and registered at the Irkutsk Regional Center for the Prevention and Control of AIDS and Infectious Diseases, Irkutsk, was carried out. The study included 172 children aged 1-18 years with perinatal HIV infection. Patients were divided into groups depending on the level of viral load: group 1 – 21 patients with viral load > 1000 copies/ml of plasma, group 2 – 42 patients with viral load 50– 1000 copies/ml of plasma, group 3 – 109 patients with undetectable viral load (< 50 copies/ml). All patients underwent standard tests in accordance with clinical guidelines for the treatment of HIV infection in children, as well as therapeutic drug monitoring. Results. Against the background of ongoing antiretroviral therapy, a significant number of patients 21 / 172 (12,2 %) experienced virological failure. The proportion of children and adolescents with incomplete suppression of HIV replication is 42 / 172 (24,4 %). Statistically significant differences were obtained by changing the ART regimen (p = 0,031). In the first group, the proportion of patients who changed the therapy regimen is 7 / 21 (33,3 %), which is two times less than in the group with a zero viral load of 70 / 109 (64,2 %). There are differences in the proportion of children and adolescents with zero concentrations of ritonavir and lopinavir (p = 0,020 and p = 0,012) in the three compared groups. The distribution of patients with zero concentrations was as follows: for ritonavir in the first group 3 / 17 (17,6 %), in the second – 8/37 (21,6 %), in the third group – 4/80 (5 %); for lopinavir – 4/17 (23,5 %), 6/36 (16,7 %), 3/80 (3,8 %), respectively. Conclusion. This study demonstrates that the prevalence of virological failure among children and adolescents receiving ART remains high. To achieve sustained virological suppression in children and adolescents taking a protease inhibitor regimen, adherence to therapy must be increased. As one of the methods for assessing adherence, therapeutic drug monitoring can be used.
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Gorgoraptis, Nikos, Joanna Zaw-Linn, Claire Feeney, Carmen Tenorio Jimenez, Mari Niemi, Aysa Malik, Timothy Ham, David Baxter, Anthony Goldstone, and David Sharp. "THE IMPACT OF TRAUMATIC BRAIN INJURY ON PATIENT-REPORTED PHYSICAL AND MENTAL HEALTH." Journal of Neurology, Neurosurgery & Psychiatry 86, no. 11 (October 14, 2015): e4.114-e4. http://dx.doi.org/10.1136/jnnp-2015-312379.26.

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Traumatic Brain Injury (TBI) is a major cause of disability, with staggering social consequences, but little is known on what determines the impact of TBI from the patient's perspective.In an audit of 240 patients (172 males, median age: 42 years, range: 20–89 years) who attended our multidisciplinary TBI clinic, we examined the impact of cognitive function, depression, sleep, history of substance abuse, age, injury severity (172 moderate-severe, 68 possible-mild TBI) and time since injury (median: 4 months, range: 20 days–28 years) on two patient-reported measures of quality of life: SF–36 Health Survey and Nottingham Health Profile (NHP).Worse outcomes in NHP and both Mental and Physical sub-scores of SF–36 were associated with poorer cognitive performance, as measured by ACE–R. Depression, examined using BDI–II, showed a strong negative correlation with both quality of life measures. Sleep-related symptoms were also strongly associated with worse patient-reported outcomes. Patients reported poorer outcomes in both SF-36 and NHP when examined at a later time since their injury, and this effect could not be attributed to older age.Impairments in cognition, mood and sleep following TBI may have a significant impact on patients' perception of their physical and mental well-being.
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Books on the topic "172/.42"

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War and Ethics: A New Just War Theory (Think Now). Continuum International Publishing Group, 2008.

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War and Ethics: A New Just War Theory. Bloomsbury Publishing Plc, 2007.

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Book chapters on the topic "172/.42"

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Semenets, O. S. "GENRE SPECIFIC OF J. GENET`S NOVELS." In NEW AND TRADITIONAL APPROACHES IN THE RESEARCHES OF MODERN REPRESENTATIVES OF PHILOLOGICAL SCIENCES, 42–58. Liha-Pres, 2019. http://dx.doi.org/10.36059/978-966-397-172-8/42-58.

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Pinilla, Carmen María. "Un lapsus arguediano en el Manuscrito de Huarochirí." In Ecos de Huarochirí: tras la huella de lo indígena en el Perú, 115–33. Pontificia Universidad Católica del Perú, 2023. http://dx.doi.org/10.18800/9786123173708.006.

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Es comprensible el interés creciente que un escritor tan complejo y testimonial como José María Arguedas despierta no solo sobre su paradigmática obra sino también sobre su vida, amarrada íntimamente a la primera. El propio Arguedas se encargó de develar la estrecha conexión entre su vida y su obra (1974, p. 167; 1988, pp. 14, 18, 22; 1983, p. 143; 1986, pp. 42, 172). Alberto Flores Galindo destacó en este sentido la unidad entre historia y biografía1 . Gonzalo Portocarrero considera que la última novela de Arguedas expresa la máxima convergencia entre reflexión autobiográfica y obra literaria y antropológica (1991, p. 232). Mario Vargas Llosa coincide al sostener que, con ella, Arguedas rompe la tradicional discreción y recato de la literatura peruana, pues el autor escarba y exhibe sin tapujos su vida íntima (1996, pp. 302, 305). Se justifica entonces el dedicar estas líneas a analizar un lapsus o errata que comete nuestro autor en su introducción a Dioses y hombres de Huarochirí, pues consideramos que evidencia inmejorablemente la influencia que produce el universo de divinidades y héroes prehispánicos contenidos en el Manuscrito en su vida íntima, en sus experiencias y dolencias. Del mismo modo, en sentido contrario, sus tribulaciones personales se reflejan en su obra, como esperamos hacer ver.
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"Rogers, G. 101 Snow, D. and Bedford, R. 151 Rowe, W. and Schelling, V. 136 Social Work and Criminal Justice 62 Social Work Research Centre (SWRC) safety 197–8; basic measures for 70; 62 designing studies for 62–3; ensuring Song, M. and Parker, D. 169 200–2; in the field 191; interview Speier, M. 149 precautions 65–6; personal Spradley, J. 149 provision for 80–1; and the Stacey, J. 108 researcher 69 Stanley, L. 16, 94, 104; and Wise, S. Said, E. 174 32, 57, 94–5, 107, 143 Santo Domingo festival: commercial Stanton, B. 151 dimension 136; costume and Staples, C. and Mauss, A. 151 greasing 136–7; danger in 133–4; Steier, F. 93 described 134–7; emotional danger at 141–2; equestrian parades 140–1; Temple, B. 100 ethical danger at 142–4; indigenous Thompson, J. 152 culture/European Catholicism in Tilly, C. 151 135–6; levels of participation in Touraine, A. 151 137–40; male/female participation Trejos Ubau, B. 134 in 138–40; meaning of icons in Turner, B.S. 32 134–5; outsider/participant Turner, R. and Killian, L. 151 relationship 133; physical danger at Uildriks, N. and van Mastrigt, H. 28, 137–42; watching/watched roles in 40 142–3 University of Stirling 62 Scarce, R. 18–19, 200 urban plunges 182, 192–3 Scientology movement 22–3, 43 Scott, A. 32 Van Maanen, J. 38–9, 58 Scott, S. 19, 20, 21–2; and Porter, M. 102 Walklate, S. 33 Scottish Office 62 Wallis, R. 17, 22–3, 43 Shaffir, W.B. 100; and Stebbins, R. 149, Walsh, D. 39 152 Warren, C.A.B. 12, 102 Sharrock, W. 58 Wax, M. 199 Shilling, C. 32 Weber, M. 93 Short, J.F. and Wolfgang, M.E. 58 Westmarland, L. 26 Skeggs, B. 108 whiteness: endangered 172–4; ethnic Slack, R. 56 dimension 174, 176; fascist elements Sluka, J.A. 28, 55, 64 176–7; liberal progressive views Smelser, N. 151 178; politically strategic role of Smith, D.J. 107; and Gray, J. 31 174–5; problems concerning 175–6;." In Danger in the Field, 221. Routledge, 2002. http://dx.doi.org/10.4324/9780203136119-42.

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"WaymackJP, Miskell P, Gonce S. Anesth Analg 69:163-198, 1989. 27. W 19 a8y7m . ackJP, Warden GD, Alexander JW, Miskell P, Gonce S. J Surg Res 42:528-535, 28. JWSauyrmgaRceksJP4 , 9 M :3 o2l8d -a 3 w 32 er , L 19 L 9 , 0 L . owry SF, Guzman RF, Okerberg CV, Mason AD, Pruitt BA. 29. WaymackJP and Yurt RW. J Surg Res 48:147-143, 1990. 30. AWnanym Su arcgk JP, 20M4( c6N ): e6a8l1N -6 , 8W5, a 1 rd 9e8n6 . GD, Balakrishnan K, Gonce S, Alexander JW, Miskell P. 31. W BA aJyrm . aAcrkcJhPS , u H rg e rn 1a2n6d : e5z9 -G 62 , , C1a9p9p1e . lli PJ, Burleson DG, Guzman RF, Mason AD Jr, Pruitt 32. Gantt CL. Lancet ii:363, 1981. 33. Chung M, Steionmetz OK, Gordon PH. BrJ Surg 80:427-432, 1993. 34. W 19 e9i2 ss . MM, Jauch KW, Delanoff CL, Memple W, Schildberg FW. Proc ASCO 11:172, 35. H Si anaggh , 1S9K8 . 8. The Blood Bank, Rotterdam: Cip - Gegevens Koninklijke Bibiliotheek, Den 36. Taylor C and Faulk WP. Lancet ii:68-69, 1981. 37. Peters WR, Fry RD, Fleshman JW, Kodner IJ. Dis Col & Rect 32(9):749-753, 1989. 38. Williams JG and Hughes LE. Lancet H31-132, 1989. 39. SGta eu st proW en H te , roBl ra SnudpA pl , 2W6: e 8 te 1 r -m 86 a , n1I9T9 , 1 . Zwinderman KH, Lamers CBHW, Gooszen. Scand J 40. Scott ADN, Ritchie JK, Phillips RKS. BrJ Surg 78:455-4587, 1991. 41. Tadros Tamer, Wobbes T, Hendriks T. Ann Surg 215(3):276-281, 1992. 42. R 74 o : s3s9 in -i 46A , A 1 , 9 F 84 a . ustman D, Woda BA, Like AA, Szymanski I, Mordes JP. J Clin Invest 43. Tartter PI, Heimann TM, Aufses AH Jr. Am J Surg 151: 358, 1986. 44. T ca anrc tt eerrpPaIt . i en Ttrsa . ns V fu osxioSnanhg is to 5r6y : , 80T , c1e9l8l9s . ub sets and natural killer cytotoxicity in colorectal 45. Beck I, Scott JS, Pepper M, Speck EH. Am J Repro Immunol 1:224, 1981. 46. Tartter PI. Transfusion 28:593-596, 1988." In Transfusion Immunology and Medicine, 302–56. CRC Press, 1995. http://dx.doi.org/10.1201/9781482273441-31.

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Conference papers on the topic "172/.42"

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Lobel, P., M. Palmer, and K. Schor. "CHRONIC ORAL DEFIBROTIDE STIMULATES VASCULAR PGI2 AND INHIBITS ATHEROSCLEROTIC PLAQUE FORMATION IN CHOLESTEROL-FED RABBITS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643150.

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Defibrotide (DEF) is a polydeoxyribonucleotide fraction from bovine lung, possessing profibrinolytic and PGI2 stimulating properties. Male rabbits were fed for 4 months a standard laboratory diet (150 g/day) without (A) or with (B) DEF or a cholesterol (1%) supplemented diet without (C) or with (D) DEF (60 mg/kg x day) was administered orally (drinking water) and withdrawn 24-36 h prior to the acute experiments.DEF did not change the elevated serum cholesterol: 18 ± 2 (C) vs. 26 ± 5 (D) mM but significantly reduced the plaque formation in the aorta from 4.5 ± 0.3 (C) to 3.3 ± 0.2 (D) (subjective score). Collagen induced (0.6 pg/ml) thromboxane formation and ATP release was significantly reduced by DEF: 55+2 (C) vs. 42 ± 2 (D) ng/ml TXB2; 152 ± 11 (C) vs. 74±5 (D) AU ATP (platelet rTch plasma). DEF significantly increased the basal and bradykinin (Bk, 30 nM) stimulated PGI2 release from rabbit aorta preparations in Krebs buffer, while the PGI2 forming capacity (arachidonic acid, AA, 30 pg/ml) was unchanged Furthermore, the iloprost (30 nM) stimulated cAMP was significantly elevated by DEF in both control: 115 ± 10 (A) vs. 155 ± 18 (B) pmoles/1 and cholesterol-fed rabbits: 120 ± 14 (C) vs. 172 ± 9 (D). DEF, directly added to the platelets in vitro did not inhibit platelet activation up to 100 pg/ml.The data demonstrate a 2-3-fold stimulation of basal and hormone (Bk) induced PGI2 formation of control and sclerotic rabbit aorta after 4 months DEF treatment while the atherosclerosis per se does not significantly change these parameters. DEF treatment also significantly reduces platelet hyperreactivity at unchanged serum ch() lesterol. Both properties might be useful to prevent complication’s of atherosclerosis, such as myocardial infarction and stroke.
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Клочков, А. В. "Структурно-функциональные изменения в почках при дистанционном ударно-волновом воздействии в эксперименте." In IX Vserossijskaja konferencija s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka». Publishing center of Ulyanovsk State University, 2023. http://dx.doi.org/10.34014/mpphe.2023-169-172.

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Исследование проводилось на 42-х половозрелых нелинейных белых крысах самцах. Животные были разделены на 5 групп: группа интактных животных (контрольная), 4 группы животных, которым однократно проводилось дистанционное ударно-волновое воздействие (ДУВВ). После ДУВВ на 1-е; 3-е; 7-е; 14-е сутки изучались маркеры повреждения и функциональных нарушений почек. Следующим этапом исследования была гистоморфологическая оценка изменений в почках животных после ДУВВ в динамике на 1-е; 3-е;7-е; 14-е сутки. Установлено, что ДУВВ на почку экспериментальных животных приводит к развитию мембрано-деструктивных процессов, к изменению структурно-функциональной организации почки, которые носят обратимый характер, восстановление происходит на 14-е сутки. Ключевые слова: Дистанционное ударно-волновое воздействие, крысы, почки, маркеры повреждения, функциональные, гистоморфологические изменения.
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