Journal articles: '171/.3'

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Khan, Md Aminul Haque, and Rukhsana Parvin. "College News 6(3)." Journal of Enam Medical College 6, no. 3 (October 20, 2016): 171. http://dx.doi.org/10.3329/jemc.v6i3.29688.

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Kuhn, Deborah J., Qing Chen, Peter M. Voorhees, John S. Strader, Kevin D. Shenk, Congcong M. Sun, Susan D. Demo, Mark K. Bennett, Fred W. van Leeuwen, and Robert Z. Orlowski. "The Novel, Irreversible Proteasome Inhibitor PR-171 Demonstrates Potent Anti-Tumor Activity in Pre-Clinical Models of Multiple Myeloma, and Overcomes Bortezomib Resistance." Blood 108, no. 11 (November 16, 2006): 3461. http://dx.doi.org/10.1182/blood.v108.11.3461.3461.

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Abstract Introduction: The ubiquitin-proteasome pathway has been validated as a therapeutic target with the approval of the small molecule proteasome inhibitor, bortezomib (VELCADE®), in multiple myeloma and non-Hodgkin lymphoma. However, the overall response rate of patients with multiple myeloma in phase III clinical trials was 43%, underscoring the need for a next generation of inhibitors with the potential for greater efficacy. Methods: PR-171 is a novel, tetrapeptide epoxomicin-related inhibitor that binds the proteasome irreversibly, and our objectives were to evaluate its activity and mechanism of action in pre-clinical models of multiple myeloma. Results: PR-171 potently bound and inhibited the chymotrypsin-like subunit of the proteasome in vitro, in cellulo, and in vivo at low concentrations. At higher concentrations, however, unlike bortezomib, which targeted the chymotrypsin-like and peptidyl-glutamyl peptide hydrolyzing activities in vivo, PR-171 also displayed significant inhibition of the trypsin-like and the peptidyl-glutamyl peptide hydrolyzing activities. PR-171-induced proteasome inhibition was associated with accumulation of polyubiquitinated substrates and pro-apoptotic Bax. Brief pulse PR-171 exposure, which simulates the in vivo pharmacokinetics of bortezomib, led to PR-171-mediated inhibition of cellular proliferation linked to induction of caspase-3-dependent apoptosis through both intrinsic (caspase-9) and extrinsic (caspase-8-dependent) pathways. Pretreatment with caspase-3, -8, and -9 inhibitors rescued the anti-proliferative effect of PR-171. Furthermore, pulse PR-171 treatment activated c-Jun-N-terminal kinase, a key-signaling molecule in proteasome inhibitor-induced apoptosis, and cleavage of poly-ADP-ribose polymerase, while abrogation of c-Jun-N-terminal kinase signaling with a dominant-negative c-Jun inhibited PR-171-induced effects. PR-171 displayed enhanced anti-proliferative activity compared to bortezomib in multiple myeloma cell lines and freshly isolated patient-derived CD138+ plasma cells, associated with enhanced phosphorylation of c-Jun-N-terminal kinase and capase-3, -8, and -9 activation. Lastly, PR-171 was a potent inhibitor of proliferation in a multiple myeloma cell line model resistant to bortezomib and in isolates from two patients, one with primary and the other with acquired bortezomib-resistance. Conclusions: These data indicate that PR-171 has enhanced activity against preclinical models of multiple myeloma, perhaps owing to its irreversible binding and subunit specificity, and provide a rationale for its translation into the clinic.

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Shen, Ye, Jennifer Ellison, Uma Chandran, Sumana Fathima, Jamil Kanji, Bonita Lee, Stephanie Smith, et al. "A 6-Year Review of Carbapenemase-Producing Organisms in Alberta, Canada." Infection Control & Hospital Epidemiology 41, S1 (October 2020): s104—s105. http://dx.doi.org/10.1017/ice.2020.608.

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Background: This review describes the epidemiology of carbapenemase-producing organisms (CPO) in both the community and hospitalized populations in the province of Alberta. Methods: Newly identified CPO-positive individuals from April 1, 2013, to March 31, 2018, were retrospectively reviewed from 3 data sources, which shared a common provincial CPO case definition: (1) positive CPO results from the Provincial Laboratory for Public Health, which provides all referral and confirmatory CPO testing, (2) CPO cases reported to Alberta Health, and (3) CPO surveillance from Alberta Health Services Infection Prevention and Control (IPC). The 3 data sources were collated, and initial CPO cases were classified according to their likely location of acquisition: hospital-acquired, hospital-identified, on admission, and community-identified. Risk factors and adverse outcomes were obtained from linkage to administrative data. Results: In total, 171 unique individuals were newly identified with a first-time CPO case. Also, 15% (25 of 171) were hospital-acquired (HA), 21% (36 of 171) were hospital-identified (HI), 33% (57 of 171) were on admission, and 31% (53 of 171) were community identified. Overall, 9% (5 of 171) resided in long-term care facilities. Of all patients in acute-care facilities, 30% (35 of 118) had infections and 70% were colonized. Overall, 38% (65 of 171) had an acute-care admission in the 1 year prior to CPO identification; 59% (63 of 106) of those who did not have a previous admission had received healthcare outside Alberta. A large proportion of on-admission cases (81%, 46 of 57) and community-identified (66%, 33 of 53) cases did not have any acute-care admissions in Alberta in the previous year. Overall, 10% (14 of 171) had ICU admissions in Alberta within 30 days of CPO identification, and 5% (8 of 171) died within 30 days. The most common carbapenemase gene identified was NDM-1 (53%, 90 of 171). Conclusions: These findings highlight the robust nature of Alberta’s provincial CPO surveillance network. We reviewed 3 different databases (laboratory, health ministry, IPC) to obtain comprehensive data to better understand the epidemiology of CPO in both the community and hospital settings. More than half of the individuals with CPO were initially identified in the community or on admission. Most had received healthcare outside Alberta, and no acute-care admissions occurred in Alberta in the previous year. It is important to be aware of the growing reservoir of CPO outside the hospital setting because it could impact future screening and management practices.Funding: NoneDisclosures: None

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Hatami, H., Sh Oryan, S. Semnanian, A. Ahmadiani, B. Kazemi, and M. Bandepour. "171 UPREGULATION OF NT-3 MRNA IN PARAGIGANTOCELLULARIS DURING MORPHINE DEPENDENCY." European Journal of Pain 10, S1 (September 2006): S47b—S47. http://dx.doi.org/10.1016/s1090-3801(06)60174-2.

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Jansson, Antti. "Parasigara multilineata de Sallier Dupin, 1973, a synonym of Corixa monticola Linnavuori, 1971, and notes on distribution of African species of Corixa (Heteroptera, Corixidae)." Entomologica Fennica 3, no. 3 (September 1, 1992): 171–72. http://dx.doi.org/10.33338/ef.83610.

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Yuzbasiyan-Gurkan, Vilma, Janver D. Krehbiel, Yueying Cao, and Patrick J. Venta. "Development and usefulness of new polymerase chain reaction-based tests for detection of different alleles at codons 136 and 171 of the ovine prion protein gene." American Journal of Veterinary Research 60, no. 7 (July 1, 1999): 884–87. http://dx.doi.org/10.2460/ajvr.1999.60.07.884.

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Abstract Objective To develop new and improved tests to detect alleles at codons 136 and 171 of the ovine prion protein locus and to evaluate the frequency of these alleles. Animals 159 Suffolk sheep belonging to 3 flocks. Procedure Polymerase chain reaction (PCR) analysis that contained diagnostic restriction site variation for each allele were developed for the relevant gene regions. Alleles were determined by analyzing DNA isolated from buccal swab specimens or blood samples. Results At codon 136, frequencies of the alanine and valine alleles were found to be 97 and 3%, respectively. At codon 171, frequencies of the glutamine, arginine, and histidine alleles were found to be 57, 41, and 2%, respectively. Conclusions Little variation was detected in codon 136, whereas noteworthy variation was found in codon 171; > 40% of the alleles at this locus coded for glutamine. Because the glutamine allele at codon 171 confers susceptibility to scrapie, reduction of its frequency is of importance to management of sheep flocks. Clinical Relevance Genotyping of sheep, using the tests reported here, should facilitate selective breeding programs designed to decrease the risk of scrapie. (Am J Vet Res 1999;60:884–887)

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Khanum, Selina. "Diagnosis and treatment of wheezing and asthma in young children." Bangladesh Medical Journal 45, no. 3 (July 5, 2017): 169–71. http://dx.doi.org/10.3329/bmj.v45i3.33141.

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Yasmin, Tarana, and Mashah Binte Amin. "Unfamiliar Large Soft Tissue Sarcoma in A 70-Year-Old Lady." Journal of Enam Medical College 7, no. 3 (October 30, 2017): 170–71. http://dx.doi.org/10.3329/jemc.v7i3.34079.

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Rahim, Muhammad Abdur. "Monkeypox: an emerging zoonotic disease with pandemic potential." BIRDEM Medical Journal 12, no. 3 (September 11, 2022): 170–71. http://dx.doi.org/10.3329/birdem.v12i3.61684.

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Sturzenegger, Luis Carlos. "Emenda Constitucional nº 3 - Empresa nacional - Empresa estrangeira." Revista de Direito Administrativo 206 (October 1, 1996): 312–16. http://dx.doi.org/10.12660/rda.v206.1996.46887.

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Chowdhury, MAK Azad. "Prematurity Management- Needs Priority Attention." Bangladesh Journal of Child Health 45, no. 3 (November 20, 2022): 168–71. http://dx.doi.org/10.3329/bjch.v45i3.62894.

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Siegel, David S., Jesus G. Berdeja, Jeffrey R. Infante, Jonathan L. Kaufman, Michael (Luhua) Wang, Thomas G. Martin, Ruben Niesvizky, et al. "Updated Results from a Phase 2 Extension Study of Patients with Multiple Myeloma or Solid Tumors Previously Enrolled in Carfilzomib Company-Sponsored Phase 1 and 2 Clinical Trials (PX-171-010)." Blood 124, no. 21 (December 6, 2014): 2134. http://dx.doi.org/10.1182/blood.v124.21.2134.2134.

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Abstract Introduction: PX-171-010 (010; NCT00884312) is an extension study of patients who completed a phase 1 or 2 carfilzomib study that aims to provide insights into the long-term tolerability, safety, and clinical benefit of carfilzomib. Methods: Patients who completed a carfilzomib study were eligible to enroll and continue receiving carfilzomib at the same dosing level, with dose adjustments permitted per protocol. Addition of other approved anticancer agents at the time of progression was allowed. The primary end point was safety; efficacy was also evaluated. Results: Between 2009 and 2012, patients with multiple myeloma (MM; n=91) or solid tumors (ST; n=9) were enrolled in this extension study. Patients were enrolled from the PX-171-002, PX-171-003-A0, PX-171-003-A1, PX-171-004, PX-171-005, PX-171-006, PX-171-007, and PX-171-008 studies (Table 1). Among patients with MM, 57.1% had prior bortezomib exposure and 95.6% had prior immunomodulatory agent (IMiD) exposure; 37.4% were refractory to bortezomib, 61.5% were refractory to an IMiD, and 31.9% were refractory to both bortezomib and an IMiD. In the initial studies, patients received 15–70 mg/m2 carfilzomib. In 010, patients received a median dose of 27 mg/m2 carfilzomib (range, 13–52 mg/m2). Median duration of carfilzomib treatment (initial study+010) was 88.9 weeks (range, 4.4–273.4 weeks). Median number of carfilzomib treatment cycles was 22.5 (range, 2–67); 60.0% of patients received carfilzomib for ≥19 cycles and 27.0% for ≥37 cycles. Treatment-emergent grade ≥3 adverse events (AEs) and serious AEs are presented in Table 2. Twenty-three patients (23.0%) had treatment-emergent AEs that led to discontinuation of study treatment, including 18 patients with MM (19.8%). Eight patients (8.0%) died on the 010 study or within 30 days of last dose of study drug, including 7 patients with MM (4 deaths due to AEs, 3 due to disease progression). One patient with ST died due to disease progression. The 4 AE deaths were due to myocardial infarction (MI; n=2), pneumonia (n=1), and pneumonia with MI (n=1). The 3 patients with MI had pre-existing cardiac disease and died after 9–47 cycles on study. None of the 8 deaths were assessed as carfilzomib-related. Overall, 74 patients (74.0%) had ≥1 regimen change. Among patients with MM, 72 patients (79.1%) had ≥1 regimen change; 22 (30.6%) of these patients continued receiving single-agent carfilzomib at a different dose/schedule, and 50 (69.4%) received additional combination therapy, including 48 patients (66.7%) who received dexamethasone, 26 (36.1%) who received lenalidomide, and 25 (34.7%) who received cyclophosphamide. Notably, responses were observed among patients with MM after regimen change due to disease progression: the overall response rate was 20.0% after first progression, 35.0% after second progression, and 30.8% after third progression. Conclusion: The types and rates of AEs in 010 were similar to those previously reported with single-agent carfilzomib. Patients were able to receive carfilzomib for an average of 89 weeks (up to 273 weeks; median of 22.5 treatment cycles) and continued receiving clinical benefit, with no new significant safety signals noted from additional cumulative exposure. Table 1 Patient Enrollment in PX-171-010 by Initial Study Table 1. Patient Enrollment in PX-171-010 by Initial Study Table 2 Treatment-Emergent Grade ≥3 or Serious AEs Occurring in ≥5% of Patients in PX-171-010 Table 2. Treatment-Emergent Grade ≥3 or Serious AEs Occurring in ≥5% of Patients in PX-171-010 Disclosures Off Label Use: Carfilzomib as treatment in multiple myeloma and solid tumors. Kaufman:Millennium: Consultancy, Honoraria; Celgene: Consultancy, Honoraria, Research Funding; Novartis: Consultancy, Honoraria, Research Funding; Onyx: Consultancy, Honoraria, Research Funding; Janssen: Consultancy, Honoraria; Spectrum: Consultancy, Honoraria; Merck: Research Funding. Wang:Onyx: Honoraria, Research Funding. Martin:Sanofi: Research Funding; Novartis: Speakers Bureau. Niesvizky:Celgene: Consultancy, Research Funding, Speakers Bureau; Millennium: Consultancy, Research Funding, Speakers Bureau; Onyx: Consultancy, Research Funding, Speakers Bureau. Reu:Onyx: Consultancy, Speakers Bureau. Jagannath:Millennium: Honoraria; Celgene: Honoraria; Onyx: Honoraria; Merck: Honoraria; Ortho Biotech: Membership on an entity's Board of Directors or advisory committees; Imedex: Membership on an entity's Board of Directors or advisory committees; Medicom Worldwide: Membership on an entity's Board of Directors or advisory committees; Optum Health Worldwide: Membership on an entity's Board of Directors or advisory committees; PER group: Membership on an entity's Board of Directors or advisory committees. Rajangam:Onyx Pharmaceuticals, an Amgen subsidiary: Employment, Equity Ownership. Huang:Onyx Pharmaceuticals: Employment. Vij:Celgene: Honoraria, Research Funding; Onyx: Honoraria, Research Funding; Sanofi: Honoraria; Jannsen: Honoraria; Novartis: Honoraria; Millennium: Honoraria; Array: Honoraria.

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Román, Maricelis Acevedo, Albeiro Molina Castañeda, Juan Carlos Angel Sánchez, Carlos Germán Muñoz, and James S. Beaver. "Inheritance of Normal Pod Development in Bean Golden Yellow Mosaic Resistant Common Bean." Journal of the American Society for Horticultural Science 129, no. 4 (July 2004): 549–52. http://dx.doi.org/10.21273/jashs.129.4.0549.

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The inheritance of resistance to bean golden yellow mosaic virus (BGYMV) was studied in common beans (Phaseolus vulgaris L.). The original cross was made between breeding line PR9556-158, which produces deformed pods when infected with BGYMV, and PR9556-171, which has normal pod development when inoculated with the virus. Pod type was evaluated on plants from six generations (parental lines, F1, F2, F2:3, F3:4, and backcrosses of the F1 to both parents) at mid-pod fill (R8), ≈65 days after planting. The segregation patterns from the F2, F2:3, F3:4, and backcross populations were consistent with the hypothesis that a single dominant gene confers normal pod development in PR9556-171. When inoculated with BGYMV, the deformed pods of PR9556-158 produced fewer seeds per pod than PR9556-171, resulting in lower seed yield. The gene symbol Bgp-1 has been assigned for this dominant resistance gene that controls the normal pod reaction to BGYMV in common bean.

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YAKOOB, J., Z. ABBAS, M. ASIM BEG, W. JAFRI, S. NAZ, A. KHALID, and R. KHAN. "Microsporidial infections due toEncephalitozoon intestinalisin non-HIV-infected patients with chronic diarrhoea." Epidemiology and Infection 140, no. 10 (December 20, 2011): 1773–79. http://dx.doi.org/10.1017/s0950268811002639.

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SUMMARYWe determined the prevalence of microsporidiaEnterocytozoon(Ent.)bieneusiandEncephalitozoon(E.)intestinalisinfection in patients with chronic diarrhoea and hepatocellular carcinoma (HCC). A total of 330 stool samples were examined from 171 (52%) patients with chronic diarrhoea, 18 (5%) with HCC while 141 (43%) were controls. Stool microscopy, polymerase chain reaction (PCR) with species-specific primers forEnt. bieneusiandE. intestinalisand sequencing were carried out. Microsporidia were found by trichrome staining in 11/330 (3%) andE. intestinalisby PCR in 13/330 (4%) whileEnt. bieneusiwas not detected. PCR forE. intestinaliswas positive in 8/171 (5%) stool samples from patients with chronic diarrhoea, 2/141 (1·4%) samples from healthy controls and in 3/18 (17%) samples from patients with HCC. In the chronic diarrhoea group,E. intestinaliswas positive in 4/171 (2·3%) (P=0·69) stool samples compared to 2/18 (11%) (P=0·06) in the HCC group and 2/141 (1·4%) from healthy controls.E. intestinalisinfection was significantly associated with chronic diarrhoea and HCC in these patients who were negative for HIV. Stool examination with trichrome or species-specific PCR for microsporidia may help establish the cause of chronic diarrhoea.

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Melling, Joseph. "Book Review: Technology, Innovation and Economic Policy." Journal of Interdisciplinary Economics 2, no. 1 (April 1987): 76–77. http://dx.doi.org/10.1177/02601079x8700200108.

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Zhang, Yong, and Nam-Gyu Park. "A thin film (<200 nm) perovskite solar cell with 18% efficiency." Journal of Materials Chemistry A 8, no. 34 (2020): 17420–28. http://dx.doi.org/10.1039/d0ta05799a.

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van der Aalst, W. M. P., K. M. van Hee, and R. A. van der Toorn. "“Compositionality of projection inheritance” [Sci. Comput. Programming 42 (2–3) (2002) 129–171]." Science of Computer Programming 44, no. 3 (September 2002): 343–44. http://dx.doi.org/10.1016/s0167-6423(02)00072-2.

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Singh, Gunjan. "Book review: South Asia Conundrum: The Great Power Gambit." Journal of Asian Security and International Affairs 8, no. 3 (November 9, 2021): 439–41. http://dx.doi.org/10.1177/23477970211039144.

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Sreepad, H. R. "First-Principles Study of Dielectric Constant and Polarizability in Two Carbon Nanotubes." Asian Journal of Science and Applied Technology 7, no. 1 (May 5, 2018): 8–10. http://dx.doi.org/10.51983/ajsat-2018.7.1.1026.

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First-principles calculations have been carried out on two Carbon Nanotubes having 54 and 72 carbon atoms. The Electronic density of state reveals that the materials show metallic nature. Dielectric constant has been computed in case of Carbon Nanotubes C54 and C72. The value of dielectric constant in Carbon Nanotube C54 comes out to be 7.06, 6.28 and 14.53 along X, Y and Z axes respectively and its average value comes out to be 9.29. Value of dielectric constant in Carbon Nanotube C72 comes out to be 167, 168 and 737 along X, Y and Z axes respectively and its average value comes out to be 357. Polarizability of Carbon Nanotube C54 has been estimated and it comes out to be 116(Å)3, 111(Å)3 and 142(Å)3 along X, Y and Z axis respectively. Polarizability in case of Carbon Nanotube C72 comes out to be 171(Å)3, 171(Å)3 and 173(Å)3 along X, Y and Z axes respectively.

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Christie, John P. "Book review: Mark Casson, The Theory of International Business: Economic Models and Methods." Vision: The Journal of Business Perspective 23, no. 4 (November 25, 2019): 468. http://dx.doi.org/10.1177/0972262919876410.

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Wang, Mingyang, Yang Liu, Kai Luo, Tengfei Li, Qingbing Liu, and Xiangli Tian. "Effects of Bacillus pumilus BP-171 and Carbon Sources on the Growth Performance of Shrimp, Water Quality and Bacterial Community in Penaeus vannamei Culture System." Water 14, no. 24 (December 10, 2022): 4037. http://dx.doi.org/10.3390/w14244037.

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A strain of Bacillus pumilus BP-171 with the ability of heterotrophic nitrification-aerobic denitrification was isolated from a shrimp culture pond and showed good denitrification ability under laboratory conditions. In order to investigate the effects of strain BP-171 and its combinations with different carbon sources, i.e., poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV) and molasses, on the growth performance of shrimp, water quality and bacterial community in culture system of Penaeus vannamei, this experiment was set up. Four experimental groups were designed, i.e., group B applied with a single B. pumilus BP-171, the BP added with BP-171 and PHBV, the BM added with BP-171 and molasses, and the control DZ without the probiotic and carbon source. The results showed that the specific growth rate, final body weight, gross weight, feed efficiency rate and survival rate of shrimp in the BP and BM groups were better than those in the control (p < 0.05), while the survival rate and gross weight of shrimp in group B were also better than those in the control (p < 0.05). Among them, the best growth performance of shrimp was observed in the group BP. The concentrations of ammonia, nitrite, nitrate and total nitrogen were significantly lower in all treatment groups than in the control (p < 0.05). The lowest concentrations of ammonia and nitrite were found in group B, while those of nitrate and total nitrogen were found in group BP (p < 0.05). The concentrations of dissolved organic carbon and total organic carbon in both BP and BM groups were significantly higher than in group B and the control (p < 0.05). Compared to the control, the abundance and diversity of the bacterial community in water did not change with the addition of probiotics and carbon sources. However, altered structure and predicted function, as well as improved stability of the ecological network of the bacterial community, were observed in water. In view of the above, the addition of B. pumilus BP-171 and PHBV significantly promoted the growth performance of shrimp, effectively improved water quality, and enhanced the stability of the ecological network of bacterial communities in water, which could have great potential for the application in intensive culture of P. vannamei.

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Sadik, Golam, Toshihisa Tanaka, Kiyoko Kato, Kentaro Yanagi, and Masatoshi Takeda. "P2-171: 14-3-3 protein exhibits strong affinity for three-repeat tau and increases its filament formation." Alzheimer's & Dementia 4 (July 2008): T420. http://dx.doi.org/10.1016/j.jalz.2008.05.1245.

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Oeschger, Hans. "Z. Jaworowski: Ancient atmosphere — Validity of ice records ESPR 1 (3) 161–171 (1994)." Environmental Science and Pollution Research 2, no. 1 (July 1995): 60–61. http://dx.doi.org/10.1007/bf02987516.

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Kuroki, Kazutaka, Yoji Sanomura, Shiro Oka, Naoki Yorita, Mio Kurihara, Takeshi Mizumoto, Yoshikazu Yoshifuku, Koji Arihiro, Shinji Tanaka, and Kazuaki Chayama. "Clinical outcomes of endoscopic resection for superficial non-ampullary duodenal tumors." Endoscopy International Open 08, no. 03 (February 21, 2020): E354—E359. http://dx.doi.org/10.1055/a-0998-3708.

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Abstract Background and study aims Because superficial non-ampullary duodenal epithelial tumors (SNADETs) are relatively rare, studies evaluating the outcomes of endoscopic resection (ER) for SNADETs are limited. Therefore, this study aimed to evaluate the clinical validity of ER for SNADETs. Patients and methods The study participants included 163 consecutive patients (108 men; mean age, 61.5 ± 11.3 years) with 171 SNADETs, excluding patients with familial adenomatous polyposis resected by ER, at Hiroshima University Hospital between May 2005 and September 2016. Clinicopathological features and the outcomes of ER for 171 cases were retrospectively analyzed. Additionally, the prognosis of 135 patients with more than 12 months’ follow-up was analyzed. Results Mean diameter of SNADETs was 10.7 ± 7.2 mm. Most of the SNADET cases were classified as category 3 (71 %, 121/171), but some were category 5 (2 %, 3/171). En bloc resection rates were 93 % (146/157), 100 % (7/7), and 86 % (6/7) in endoscopic mucosal resection (EMR), polypectomy, and in endoscopic submucosal dissection (ESD) cases, respectively. Complete resection rates were 90 % (141/157), 100 % (7/7), and 71 % (5/7) in EMR, polypectomy, and ESD cases, respectively. Emergency surgery was performed in two patients with intraoperative perforation and in two with delayed perforation without artificial ulcer bed closure after ER. Since endoscopic closure of ulcer by clipping was performed, delayed perforation has not occurred. Local recurrence occurred in 1.2 %, but no metastasis to lymph nodes or other organs occurred after ER. No patient died of primary SNADETs. Conclusion Our data supported the clinical validity of ER for SNADETs. However, delayed perforation should be given much attention.

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Bland, Christopher M., P. Brandon Bookstaver, Z. Kevin Lu, Brianne L. Dunn, and Kathey Fulton Rumley. "Musculoskeletal Safety Outcomes of Patients Receiving Daptomycin with HMG-CoA Reductase Inhibitors." Antimicrobial Agents and Chemotherapy 58, no. 10 (July 14, 2014): 5726–31. http://dx.doi.org/10.1128/aac.02910-14.

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ABSTRACTDaptomycin, a cyclic lipopeptide antibiotic, and 3-hydroxy-3-methylglutaryl–coenzyme A (HMG-CoA) reductase inhibitors (statins) are commonly administered in the inpatient setting and are associated with creatine phosphokinase (CPK) elevations, myalgias, and muscle weakness. Safety data for coadministration of daptomycin with statins are limited. To determine the safety of coadministration of daptomycin with statin therapy, a multicenter, retrospective, observational study was performed at 13 institutions in the Southeastern United States. Forty-nine adult patients receiving statins concurrently with daptomycin were compared with 171 patients receiving daptomycin without statin therapy. Detailed information, including treatment indication and duration, infecting pathogen, baseline and subsequent CPK levels, and presence of myalgias or muscle complaints, was collected. Myalgias were noted in 3/49 (6.1%) patients receiving combination therapy compared with 5/171 (2.9%) of patients receiving daptomycin alone (P= 0.38). CPK elevations of >1,000 U/liter occurred in 5/49 (10.2%) patients receiving combination therapy compared to 9/171 (5.3%) patients receiving daptomycin alone (P= 0.32). Two of five patients experiencing CPK elevations of >1,000 U/liter in the combination group had symptoms of myopathy. Three patients (6.1%) discontinued therapy due to CPK elevations with concurrent myalgias in the combination group versus 6 patients (3.5%) in the daptomycin-alone group (P= 0.42). CPK levels and myalgias reversed upon discontinuation of daptomycin therapy. Overall musculoskeletal toxicity was numerically higher in the combination group but this result was not statistically significant. Further prospective study is warranted in a larger population.

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Scott, Joan W. "Comment." differences 3, no. 3 (November 1, 1991): 171–75. http://dx.doi.org/10.1215/10407391-3-3-171.

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Ijspeert, Auke Jan, Alessandro Crespi, and Jean-Marie Cabelguen. "Simulation and Robotics Studies of Salamander Locomotion: Applying Neurobiological Principles to the Control of Locomotion in Robots." Neuroinformatics 3, no. 3 (2005): 171–96. http://dx.doi.org/10.1385/ni:3:3:171.

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Bamias, Aristotle, and Nicholas Pavlidis. "Systemic Chemotherapy in Gastric Cancer: Where Do We Stand Today?" Oncologist 3, no. 3 (June 1998): 171–77. http://dx.doi.org/10.1634/theoncologist.3-3-171.

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Hynninen, Paavo H., Juho Helaja, Franz-Peter Montforts, and Claudia M. Müller. "Complete assignment of the 1H and 13C NMR spectra and conformational analysis of bonellin dimethyl ester." Journal of Porphyrins and Phthalocyanines 08, no. 12 (December 2004): 1376–82. http://dx.doi.org/10.1142/s1088424604000738.

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The use of a high-field NMR instrument (ν(1 H ) = 500 MHz ) and 2-dimensional NMR techniques (HMQC, HMBC, ROESY) enabled us to fully assign the 1 H and 13 C chemical shifts of bonellin dimethyl ester. The β-pyrrolic proton of C -3 appeared as a broad singlet at δ = 8.93, whereas that of C -8 gave a quartet with δ = 8.69 and 4J H - H = |1.28| Hz . The C -21 methyl protons appeared as a doublet with δ = 3.55 and 4J H - H = |1.07| Hz , while the C -71 methyl protons afforded a doublet with δ = 3.51 and 4J H - H = |1.28| Hz . These results suggest that the β-pyrrolic carbons of ring A belong to the aromatic 18 π-electron [18]diazaannulene delocalization pathway, whereas those of ring B remain outside the aromatic pathway. The broadening of the C -3 β-pyrrolic proton signal can be attributed to the allylic 3- CH - 21- CH 3 coupling and the 3- CH - 21- NH coupling. At 330 K, the tautomeric exchange 21- NH a ⇌ 23- NH b is fast and only one broad signal at δ = -2.49 is seen for these protons. The ROESY spectrum showed clear correlation signals between the 182- CH 3 and 171- CH 2 protons, the 182- CH 3 and 174- CH 3 protons, as well as between the 181- CH 3 and 17- CH protons. These results are compatible with the previous assignment that the absolute configuration at C-17 is S. Application of spin simulation enabled us to determine the chemical shifts and the 3J H - H coupling constants of the 17-propionate side-chain. The 3J H - H -values were used to calculate the populations for the 171-17 and 172-171 rotamers. A relatively high population value of 0.41 was found for the 171-17 g--rotamer, whose methoxycarbonylmethyl group points to the C -15 methine-bridge. This was interpreted as explaining the high tendency of bonellin to form anhydrobonellin. The rotational freedoms in the 13-propionate side-chain were studied by measuring the 1 H NMR spectra of the side-chain at temperatures between 300 and 195 K. At 300 K, the 131- and 132- CH 2 proton signals appeared as deceptively simple triplets, which at 195 K were split into complex multiplets. At 195 K, the signal arising from the 131- CH 2 protons exhibited more splitting, which indicates that these protons have less rotational freedom than the 132- CH 2 protons.

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Jagannath, Sundar, Ravi Vij, Jonathan L. Kaufman, Thomas Martin, Ruben Niesvizky, Nashat Y. Gabrail, Melissa Alsina, et al. "Long-Term Treatment and Tolerability of the Novel Proteasome Inhibitor Carfilzomib (CFZ) In Patients with Relapsed and/or Refractory Multiple Myeloma (R/R MM)." Blood 116, no. 21 (November 19, 2010): 1953. http://dx.doi.org/10.1182/blood.v116.21.1953.1953.

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Abstract Abstract 1953 Background: Carfilzomib (CFZ) is a novel, selective proteasome inhibitor that differs from BTZ both structurally and mechanistically. CFZ overcomes BTZ-resistance in vitro, lacks the off-target activities of BTZ in preclinical studies, and does not cause neurotoxicity in long-term (6–9 month) chronic animal toxicology studies. Single-agent CFZ produces durable responses in relapsed and relapsed/refractory (R/R) multiple myeloma (MM) without dose-limiting PN, and can be given to pts with substantial renal dysfunction. Here we report on the clinical experience with long-term treatment (>12 cycles, >11 months) with single-agent CFZ in pts with MM. Methods: Included in the present analysis were pts with MM who initially enrolled in studies PX-171-002 (Phase 1), PX-171-003 (relapsed and refractory MM), PX-171-004 relapsed following 1–3 therapies), and PX-171-005 (relapsed and refractory MM with varying degrees of renal dysfunction). The majority of pts initially received CFZ at 20 mg/m2 IV, on Days 1, 2, 8, 9, 15, and 16 in a 28-day cycle (C). In some trials, the dose was escalated following cycle 1 to 27 mg/m2 for up to 12 C. Recently, higher doses including 36 and 45 mg/m2 have been successfully attempted using a 30-min infusion. Pts who completed their full course of CFZ therapy on a given trial were given the option to enter the PX-171-010 extension study. In this extension study, CFZ was initially administered at the same dose-level and frequency as given in the last cycle of the pts’ previous CFZ study. CFZ could be administered at a reduced frequency of twice weekly every other week at the discretion of the investigator and pts could continue treatment until disease progression or unacceptable toxicity. Results: More than 10% of pts in studies PX-171-003 and PX-171-005, and approximately 24% of pts in PX-171-004 completed 12 cycles of induction therapy with CFZ (QDx2 weekly for 3 of 4 weeks). As of 31 July 2010, 42 of the pts completing 12 cycles of CFZ in a previous study either enrolled in PX-171-010 (N=38) or were treated on single-patient INDs prior to the availability of PX-171-010 (N=4). CFZ was administered as either a single agent (N=38) or combined with low-dose dexamethasone (N=4, all in PX-171-005). Twenty-five of the 42 MM pts (60%) remain on treatment: 24 receiving single agent CFZ at 27 mg/m2 (range 15–45 mg/m2) and 1 receiving CFZ + low dose dexamethasone. The median duration of CFZ treatment in this cohort is 14 months. The longest period of treatment is >27 months, and 12 pts have completed over 18 months of total continuous CFZ dosing. Of the 17 MM pts who discontinued therapy, 16 did so due to progressive disease and one pt had pneumonia, stopped therapy, and elected not to restart treatment. Cumulative toxicities were not observed, and AEs were similar to those reported in other studies of single-agent CFZ. There were 7 serious adverse events (SAEs, 1 patient each) reported in the extension study: 4 were possibly related and included infection, dyspnea, bronchitis and asthenia. Doses were interrupted and restarted or maintained for all of the pts with possibly related SAEs. Peripheral neuropathy and significant renal dysfunction were not observed with in this extension trial. Conclusions: CFZ is a highly selective proteasome inhibitor that can be administered to pts with MM for prolonged periods with no apparent cumulative toxicities. Disease control is possible with this single-agent treatment, even though many of the pts had disease that was refractory to multi-agent therapy prior to entering their initial CFZ trial. Following 12 cycles (11 months) of induction therapy (QDx2 weekly for 3 of 4 weeks) maintenance CFZ sustained disease control and provided excellent long-term tolerability, with the option for pts to switch to twice weekly dosing every other week. Disclosures: Jagannath: Celgene: Honoraria; Millenium/Takeda Pharma: Honoraria; J&J Family: Honoraria; Onyx: Honoraria; Merck: Honoraria. Vij:Onyx: Honoraria. Kaufman:Celgene, Millenium: Consultancy; Celgene, Merck: Research Funding. Martin:Celgene: Honoraria; Onyx: Consultancy. Niesvizky:Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Millenium: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Onyx: Consultancy, Research Funding. Gabrail:Millenium: Research Funding. Alsina:Millenium: Consultancy, Research Funding; Celgene: Research Funding; Novartis: Consultancy. Wong:Onyx Pharmaceuticals: Employment. Le:Onyx Pharmaceuticals: Employment. McCulloch:Onyx Pharmaceuticals: Employment. Hannah:Onyx Pharmaceuticals: Consultancy. Kauffman:Onyx Pharmaceuticals: Employment. Siegel:Millenium: Consultancy, Honoraria; Celgene: Consultancy, Honoraria.

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Nkogwe, Comfort, Juliah Raletobana, Alva Stewart-Johnson, Sharianne Suepaul, and Abiodun Adesiyun. "Frequency of Detection ofEscherichia coli,Salmonellaspp., andCampylobacterspp. in the Faeces of Wild Rats (Rattusspp.) in Trinidad and Tobago." Veterinary Medicine International 2011 (2011): 1–7. http://dx.doi.org/10.4061/2011/686923.

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The study was conducted to determine the frequency of isolation ofSalmonella,CampylobacterandE. coliO157 in the faecal samples of rats trapped across the regional corporations in Trinidad and to assess their resistance to antimicrobial agents. A total of 204 rats were trapped for the detection of selected bacteria. Standard methods were used to isolateSalmonella,CampylobacterandE. coliO157. Characterization ofE. coliwas done on sorbitol MacConkey agar to determine non-sorbitol fermentation, blood agar to determine haemolytic and mucoid colonies and by usingE. coliO157 antiserum to determine O157 strain. The disc diffusion method was used to determine resistance to nine antimicrobial agents. Of the 204 rats, 4 (2.0%), 7 (3.4%) and 171 (83.8%) were positive forSalmonellaspp.,Campylobacterspp. andE. coli, respectively. Of the 171 isolates ofE. colitested 0 (0.0%), 25 (14.6%) and 19 (11.1%) were haemolytic, mucoid and non-sorbitol fermenters, respectively. All isolates were negative for the O157 strain. The frequency of resistance to the 9 antimicrobial agents tested was 75% (3 of 4) forSalmonella, 85.7% (6 of 7) ofCampylobacterspp. and 36.3% (62 of 171) forE. coli(;χ2).

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Stewart, K. A., O. A. O’Connor, M. Alsina, S. Trudel, P. R. Urquilla, M. K. Vallone, C. J. Molineaux, A. Goy, and R. Z. Orlowski. "Phase I evaluation of carfilzomib (PR-171) in hematological malignancies: Responses in multiple myeloma and Waldenstrom’s macroglobulinemia at well-tolerated doses." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 8003. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.8003.

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8003 Background: Carfilzomib is a novel, irreversible tetrapeptide proteasome inhibitor derived from the natural product epoxomicin. Carfilzomib was well tolerated in preclinical animal studies when administered on a two-week cycle, QDx5; proteasome inhibition one hour after dosing at the MTD was >80%. Two Phase I dose-escalation studies are ongoing, aimed at determining the safety, tolerability, and biological response to carfilzomib. Methods: Carfilzomib was administered according to two different dose-intensive schedules. In PX-171–001, carfilzomib was administered on a two week cycle, QDx5 with nine days rest; in PX-171–002, carfilzomib was administered on a four week cycle, QDx2 weekly for three weeks with 12 days rest. Eligible patients have multiple myeloma (MM), Non-Hodgkin's Lymphoma (NHL), Hodgkin's Disease (HD), or Waldenström's Macroglobulinemia (WM). Results: Thus far, a total of 54 subjects have been enrolled. Although the maximum tolerated dose (MTD) has not yet been identified on either study, responses seen on both protocols have established 11 and 15 mg/m2 as the minimal effective doses (MEDs) on PX-171–001 and 002, respectively. Of 3 patients with MM or WM treated on the 001 protocol, one MM patient has had a Partial Response (PR) and one WM patient had a Minimal Response (MR). Of 8 patients with MM treated on the 002 protocol, 3 patients have had PRs. 6 additional patients have had Stable Disease lasting longer than 6 months and symptomatic improvement has been seen in patients on both protocols. 11 subjects remain on study with stable disease or better. Proteasome inhibition in whole blood at the highest dose levels exceeded 80% one hour after the first dose. Carfilzomib has been well tolerated at doses at and above the MED thus far. There has been no incidence of painful peripheral neuropathy on either study. No dose-limiting toxicities (DLTs) have occurred on PX-171–001; one DLT (Gr 4 anemia and thrombocytopenia) was observed at 27 mg/m2 on PX-171–002. Conclusions: Thus far, intensive dosing with carfilzomib is well-tolerated at proteasome inhibition levels of more than 80%. Five responses have been observed, and several subjects have achieved long lasting SD and/or symptomatic improvement. No significant financial relationships to disclose.

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Movchan, Roman, and Andrey Hel. "Criminal liability for interfering with the legal professional activities of journalists (art. 171 of the Criminal Code): a scientific and practical comment." Scientific and informational bulletin of Ivano-Frankivsk University of Law named after King Danylo Halytskyi, no. 17(29) (June 12, 2024): 269–81. http://dx.doi.org/10.33098/2078-6670.2024.17.29.269-281.

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Purpose. Scientific and practical commentary on certain provisions of Art. 171 of the Criminal Code of Ukraine. In order to achieve the declared goal, an appropriate methodology was chosen, in particular, philosophical, general scientific and specifically scientific methods were used. Based on the results of writing the article, firstly, recommendations were formulated for solving those debatable issues, the lack of answers to which can prevent effective law enforcement of Art. 171 of the Criminal Code of Ukraine, secondly, the shortcomings inherent in the corresponding norm were identified, the presence of which already negatively affects its effectiveness, and proposals were made for their elimination. The scientific novelty lies in the fact that new recommendations on qualifications and proposals for improving certain provisions of Art. 171 of the Criminal Code of Ukraine. In particular, it was proven that cases of mental or physical pressure on the journalist's close relatives should not be qualified under Art. 171, and according to Art. 345-1 of the Criminal Code of Ukraine. Additional arguments are presented in favor of the fact that instead of enumerating the forms of obstruction to the legal professional activity of a journalist in the analyzed criminal law norm, it would be appropriate to point to the single generalizing term "obstruction", which, among other things, included the concept of "influence". Recommendations for distinguishing the investigated criminal offense from criminal offenses against life and health have been developed. The proposal of the researchers to present Part 3 of Art. 171 of the Criminal Code of Ukraine in the following wording: "Actions provided for in part 1 or part 2 of this article, if they were committed by an official using his official position or with the prior conspiracy of a group of persons". Practical significance. Formulated conclusions can be used in rule-making, law enforcement and scientific activities.

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Dou, Shi-qi, B. Thimme Gowda, Helmut Paulus, and Alarich Weiss. "The Bond N-Cl. Crystal Structures and 35Cl NQR of N-Chloro-N-Phenyl-2-chloroacetamide, N-Chloro-N-phenyl-2,2-dichloroacetamide, N-Chloro-N-phenyl-2,2,2-trichloroacetamide, and N-Phenyl-2,2,2-trichloroacetamide." Zeitschrift für Naturforschung A 49, no. 12 (December 1, 1994): 1136–44. http://dx.doi.org/10.1515/zna-1994-1206.

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Abstract The crystal structures of C6H5NClCOCH2Cl (1), C6H5NClCOCHCl2 (2), C6H5NClCOCCl3 (3),and C6H5NHCOCCl3 (4) have been determined at room temperature (lattice constants, d in pm).(1): P21 /c, Z = 4, a = 738, b = 645, c = 1891, β = 90.41°, d (N -C l) = 171, d (C = O ) = 121; (2): P21 /c, Z = 4, a = 820, b = 1495, c = 905, β = 114.78°, d (N -Cl) = 171, d (C = O ) = 120; (3): P 21/c, Z = 4,a = 819, b = 1853, c = 718, β = 103.64°, d (N -Cl) = 172, d (C = O ) = 120; (4): P21/c, Z = 4, a = 551, b = 1704, c = 1035, β = 93.08°, d (C = O) = 121.For (2), (3), and (4) the 35Cl NQR frequencies have been determined in the range 77 ≤ T /K ≤ 300. At 77 K (γ in MHz): (2): γ(w,1) = 37.600, γ(w,2) = 38.188, γ(N) = 51.858; (3): γ(w,1) = 39.944, γ(w,2) = 40.512, γ(w,3) = 40.739, γ(N) = 52.791; (4): γ(w,1) = 39.428, γ(w,2) = 39.452, γ(w,3) = 39.986. For the compound C6H5NHCOCHCl2 (5) the 35Cl NQ R measured at 77 K is: γ(w,1) = 37.195 MHz, γ(w,2) = 37.596 MHz. The relation, γ(35Cl) = d (N -Cl) is discussed.

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Guediri, Mohammed, and Mona Bin-Asfour. "Ricci-flat left-invariant Lorentzian metrics on 2-step nilpotent Lie groups." Archivum Mathematicum, no. 3 (2014): 171–92. http://dx.doi.org/10.5817/am2014-3-171.

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Azizi, Abdelmalek, Jamal Benamara, Moulay Chrif Ismaili, and Mohammed Talbi. "The reduced ideals of a special order in a pure cubic number field." Archivum Mathematicum, no. 3 (2020): 171–82. http://dx.doi.org/10.5817/am2020-3-171.

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Kuhn, Deborah J., Peter M. Voorhees, John S. Strader, Kevin D. Shenk, Congcong M. Sun, Susan D. Demo, Mark K. Bennett, and Robert Z. Orlowski. "Potent Activity of a Novel, Irreversible Inhibitor of the Ubiquitin-Proteasome Pathway Against Pre-Clinical Models of Multiple Myeloma." Blood 106, no. 11 (November 16, 2005): 1576. http://dx.doi.org/10.1182/blood.v106.11.1576.1576.

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Abstract The proteasome is a multi-catalytic proteinase complex that is integral to intracellular proteolysis, and plays a key role in many cell functions. Targeting the proteasome with small molecule inhibitors has been validated as a rational therapeutic strategy for patients with relapsed/refractory myeloma with the approval of the first proteasome inhibitor, bortezomib (VELCADE®), for this indication. Additional studies are ongoing to better define the role of this agent in myeloma and other diseases, including non-Hodgkin’s lymphoma. Since bortezomib is a reversible proteasome inhibitor, we considered the possibility that an irreversible agent might have novel, potentially attractive properties. To begin to evaluate this hypothesis, we have studied the efficacy of a novel epoxomicin-related proteasome inhibitor, PR-171, which binds irreversibly and with a high degree of specificity in vitro to the chymotrypsin-like subunit of the proteasome. PR-171 was able to inhibit proliferation of both interleukin (IL)-6-dependent ANBL-6 and KAS-6 cell lines, as well as IL-6-independent models, including RPMI 8226 and U266 cells, in a concentration- and time-dependent fashion. IL-6-dependent cells generally displayed a greater sensitivity to PR-171-mediated effects than IL-6-independent cells. Experiments modeling the in vivo pharmacokinetics of proteasome inhibitors, with a one-hour pulse of drug followed by a washout, showed that PR-171 indeed inhibited the chymotrypsin-like activity of the proteasome without effects on other proteasome proteases. Inhibition of cell proliferation was associated with an induction of programmed cell death, as judged by the appearance of apoptotic oligonucleosome DNA fragments, as well as by the activation of caspase-3. This common effector caspase was activated by both the extrinsic and intrinsic pathways, in that both caspase-8 and caspase-9 were potently induced. Additionally, pulse treatment of PR-171 induced activation of c-Jun-N-terminal kinase, a key signaling molecule in stress-induced and proteasome inhibitor-induced apoptosis. Other members of the stress response-signaling pathway, including heat shock protein-70 and mitogen activated protein kinase phosphatase-1, were induced as well. Finally, both continuous and pulse treatment with PR-171 was also able to inhibit proliferation in freshly purified patient-derived multiple myeloma plasma cells, including isolates from patients with both newly diagnosed, previously untreated disease, as well as isolates from patients who had progressed on other standard therapies, including bortezomib. Importantly, PR-171 was active in both myeloma cell line models and patient-derived samples with chromosome 13 abnormalities. Taken together, these data indicate that PR-171 is a promising, novel proteasome inhibitor with activity against models of multiple myeloma, providing a rational basis for its translation into the clinic.

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Vaiva, G. "N’oublions pas les survivants ! Impact psycho-économique de la tentative de suicide sur les proches du suicidant." European Psychiatry 28, S2 (November 2013): 46–47. http://dx.doi.org/10.1016/j.eurpsy.2013.09.120.

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HypothèseLa tentative de suicide d’un sujet propage une souffrance en cascade sur les différents cercles de l’entourage familial et affectif, qui peut se mesurer en termes de stress traumatique et d’impact médicoéconomique. Chaque année, 3 750 000 français sont concernés par une TS de l’un de leurs proches.Sujets étudiésHomme ou femme, âgé de plus de 16 ans sans limite supérieure d’âge, membre de l’entourage proche d’un suicidant (sujets habitant sous le même toit que le suicidant). Au total, 171 familles ; soit 171 suicidants et 171 « informateurs ménages ». Ces sujets ont été comparés aux données de l’Institut de recherche et de documentation en économie de la santé (IRDES) sur la population française (échantillon de 20 000 personnes, représentatif de 95 % des ménages français). L’ensemble des sujets a été recontacté par téléphone après 3 mois et 1 an.RésultatsQuatre-vingt-sept pour cent des proches vont « plutôt bien » à 1 an ; les 13 % qui vont moins bien sont importants à qualifier au plus tôt après la TS. Un modèle explicatif de la probabilité d’aller mal après 1 an est possible ; modèle dominé par l’impact psychotraumatique de la scène suicidaire ou de l’activation des secours (70 % de symptômes psychotraumatiques dans ce sous-groupe). Sur le plan médicoéconomique, nous observons une grande stabilité des contacts de soin à 1 an, qui contraste avec une forte augmentation des consommations médicamenteuses (×2,37) ; toutes les catégories pharmacologiques sont concernées. L’hypothèse d’une automédication en partie non consciente et non perçue est soulevée.

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Bashir, Iram, Sheikh Qais Falah, and Asif Shams. "Triple Negative Receptor Status in Patients Diagnosed with Carcinoma Breast." Pakistan Journal of Medical and Health Sciences 16, no. 2 (February 26, 2022): 530–32. http://dx.doi.org/10.53350/pjmhs22162530.

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Objective: To record frequency of triple negative receptor status in patients diagnosed with carcinoma breast. Methodology: This descriptive cross-sectional survey, was conducted at Surgical Unit III, Nishtar Hospital Multan, we included 171 females between 30-60 years of age diagnosed to have breast carcinoma on histopathology whereas those unfit to undergo surgical excision, established metastatic disease were excluded from the study. All these patients were undergo mastectomy by Consultant surgeon (having 5 years’ post-fellowship experience). All the specimens were sent to areference laboratory(Shaukat Khanam Memorial Trust Hospital) for immune staining for presence or absence of Esterogen receptor, Progesterone receptor and Her / neu receptor. Frequency was calculated for triple negativereceptor status (present/absent). Results: Total patients included in this study were 171 (100%) all were female. These 171 patients were divided into 3 groups, patients from 30-40 years included in group 1, age 41-50 included in group 2 and patients from 51-60 years included in group 3. According to age patients in which TNBC was present were have mean age 44.06 and standard deviation 9.107 similarly patients in which TNBC was absent were have mean age of 44.32 and standard deviation 8.953. According to TNBC patients of group 1 (30-40 years), 13 were have TNBC present and 53 were not, out of 55 patients of group 2 (41-50 years), 12 were have TNBC present and 43 were not, similarly out of 50 patients in group 3 (51-60), 10 were have TNBC present and 40 were not. Conclusion: Frequency of TNBC in patients of Carcinoma breast is 35% in our society. Keywords: Breast Cancer, TNBC, Female, Mammography.

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Lapointe, Sarah, Marie Florescu, David Simonyan, and Karine Michaud. "Impact of standard care on elderly glioblastoma patients." Neuro-Oncology Practice 4, no. 1 (December 9, 2016): 4–14. http://dx.doi.org/10.1093/nop/npw011.

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Abstract Background. Uncertainty persists about the survival advantage of concomitant and adjuvant temozolomide (TMZ) plus radiotherapy (RT) in elderly patients with newly diagnosed glioblastoma (GBM). We compared the clinical outcome of unselected elderly GBM patients treated with 4 adjuvant treatment modalities, including the Stupp protocol. Methods. From 2010 to 2014, retrospective chart review was performed on 171 GBM patients aged ≥55 who received either concurrent chemoradiation therapy (CCRT) with standard 60 Gy/30 (SRT); CCRT with hypofractionated 40 Gy/15 (HRT); HRT alone; or TMZ alone. Stratification is by age (55–69, ≥70), KPS (<70, ≥70), and resection status (biopsy, resection). Results. Out of 171 patients identified, 128(75%) had surgical resection, median age was 66(55–83), and median overall survival (mOS) 11.4mo. Majority (109/171) were treated according to the Stupp protocol (CCRT-SRT), and 106/171 received post-CCRT adjuvant TMZ (median of 3 cycles). In our population, age <70yo was a significant prognostic factor (mOS of patients aged 55–69 vs ≥70 yo = 13.3 vs 6.6 mo; P = .001). However, among the population receiving the Stupp regimen, there was no difference in survival between patients aged 55–69 and those ≥70 (respectively, 14.4 vs 13.2 mo; P = .798). Patients ≥70 yo had similar survival when treated with CCRT-HRT and CCRT-SRT (P = .248), although numbers were small. Conclusions. Our data suggests that, despite having a worse global prognostic than their younger counterparts, GBM patients ≥70yo with a good performance status could be treated according to the Stupp protocol with similar survival. Theses results need prospective confirmation.

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Katzenmayer, Markus M., Benjamin M. Wolf, Alexandros Mortis, Cäcilia Maichle-Mössmer, and Reiner Anwander. "Polymeric dimethylytterbium and the terminal methyl complex (TptBu,Me)Yb(CH3)(thf)." Chemical Communications 57, no. 2 (2021): 243–46. http://dx.doi.org/10.1039/d0cc06981g.

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Pyrophoric redox-sensitive [YbMe₂]_n is obtained from [Yb{N(SiMe₃)₂}₂]₂ and methyllithium and its existence proven by ¹⁷¹Yb CP/MAS NMR spectroscopy and distinct methane elimination reactions.

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สุดจิตร, สุชาดา. "กลยุทธ์การตลาดดิจิทัลบนแพลตฟอร์มออนไลน์ของ Shopee ที่ส่งผลต่อการตัดสินใจซื้อซ้ำของผู้บริโภคในจังหวัดภูเก็ต." Parichart Journal 36, no. 3 (July 21, 2023): 20–36. http://dx.doi.org/10.55164/pactj.v36i3.261647.

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การวิจัยครั้งนี้มีวัตถุประสงค์เพื่อ 1) ศึกษาระดับความคิดเห็นต่อกลยุทธ์การตลาดดิจิทัลบนแพลตฟอร์มออนไลน์ของ Shopee 2) ศึกษาระดับความคิดเห็นของผู้บริโภคต่อการตัดสินใจซื้อซ้ำบนแพลตฟอร์มออนไลน์ของ Shopee 3) ศึกษากลยุทธ์การตลาดดิจิทัลบนแพลตฟอร์มออนไลน์ของ Shopee ที่ส่งผลต่อการตัดสินใจซื้อซ้ำของผู้บริโภคในจังหวัดภูเก็ต กลุ่มตัวอย่าง เป็นผู้บริโภคที่เคยซื้อสินค้าบนแพลตฟอร์มออนไลน์ของ Shopee ในจังหวัดภูเก็ต จำนวน 420 ตัวอย่าง ใช้วิธีสุ่มตัวอย่างแบบชั้นภูมิ ใช้แบบสอบถามเป็นเครื่องมือเก็บรวบรวมข้อมูล ใช้สถิติ ความถี่ ร้อยละ ค่าเฉลี่ย ส่วนเบี่ยงเบนมาตรฐาน การวิเคราะห์สถิติถดถอยพหุคูณ ผลการวิจัยพบว่า 1. ระดับความคิดเห็นต่อกลยุทธ์การตลาดดิจิทัลบนแพลตฟอร์มออนไลน์ของ Shopee โดยรวม อยู่ในระดับมาก (ค่าเฉลี่ย 4.31) 2. ระดับความคิดเห็นของผู้บริโภคต่อการตัดสินใจซื้อซ้ำบนแพลตฟอร์มออนไลน์ของ Shopee โดยรวม อยู่ในระดับมาก (ค่าเฉลี่ย 4.36) 3. การตลาดดิจิทัลบนแพลตฟอร์มออนไลน์ของ Shopee ส่งผลต่อการตัดสินใจซื้อซ้ำของผู้บริโภคในจังหวัดภูเก็ต อย่างมีนัยสำคัญทางสถิติที่ .05 เรียงลำดับตามน้ำหนักของผลกระทบได้แก่ ด้านการตลาดเชิงเนื้อหา (Beta= .359) ด้านสื่อสังคม (Beta= .193) ด้านเว็บไซต์/แอปพลิเคชัน (Beta= .171) ด้านครองหน้าแรก (Beta= .147) และด้านจดหมายอิเล็กทรอนิกส์ (Beta= .126) ตามลำดับ นอกจากนี้สามารถอธิบายความผันแปรของตัวแปรตาม คือการตัดสินใจซื้อซ้ำโดยรวมของผู้บริโภคในจังหวัดภูเก็ต ได้ร้อยละ 77

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Otayk, Soleman M. Al, Abdulrahman A. AL Soqeer, Abd Elsalam M. Menshawy, and Mohamed I. Motawei. "Evaluation of some bread wheat genotypes popular in Saudi Arabia under drought stress." November 2019, no. 13(11):2019 (November 20, 2019): 1892–900. http://dx.doi.org/10.21475/ajcs.19.13.11.p1330.

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Six bread wheat genotypes were evaluated in three separate irrigation regime experiments to compare the response of agronomic performance and to identify genotypes with high yield potential under drought stress. The first irrigation treatment (I3) was given normal water irrigation (about 7000 m3 ha-1, according to recommendation for Qassim Region). The second (I2) and third (I1) treatments were given 2/3 and 1/3 of water amount of the first treatment, respectively. Factorial experiments in randomized complete block design with three replications were conducted during 2009/2010 and 2010/2011 seasons in the arid environment of central region of Saudi Arabia. Measurements were taken on days to heading, plant height, number of spikes m-2, number of kernels spike-1, 1000-kernel weight and grain yield. The drought susceptibility index (DSI) and water utilization efficiency (WUE) were calculated. The results revealed that effect of irrigation regime was highly significant for all traits, except days to heading. All studied characters were significantly decreased by reducing the amount of irrigation water. Grain yield showed maximum sensitivity as affected by moisture-stress. Means over environments indicated the existence of sufficient genetic variability among the genotypes for all the characters studied. Giza 171 recorded the highest values for most yield characters, while genotype 'Sama' was the lowest for the most yield characters. Giza 171, Sakha 93 and IC-1 recorded highest grain yield and WUE, based on average over irrigation treatments. Giza 171, Sakha 93 and IC-2 can be considered as drought stress tolerant genotypes.

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Koduru, Srinivas V. "Abstract 2291: microRNA/mRNA integrated analysis of multiple myeloma transcriptomics." Cancer Research 82, no. 12_Supplement (June 15, 2022): 2291. http://dx.doi.org/10.1158/1538-7445.am2022-2291.

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Abstract Myeloma is plasma cell disorder, mostly effects adults over 60 years. Non-coding RNAs are emerging field and play vital role in development of disease. Major non-coding RNAs are miRNAs, lncRNAs, circRNAs and sn/snoRNAs. We analyzed restricted and publically available RNA-seq and small RNA-seq data sets for biomarkers identification and their involvement in myeloma. We obtained restricted data from “BluePrint”, which contains 11 myeloma plasma cells and 4 normal tonsil plasma cells (EGAS00001001110). We identified 1534 genes are differentially regulated (2-fold cut-off, >10-FC 218 genes). Top 10 upregulated genes were: EDNRB (1246-FC), SCUBE1 (737-FC), MC4R (691-FC), NDNF (601-FC), PTGS2 (567-FC), GPRC5D (531-FC), MFAP3L (467-FC), CCND1 (381-FC), CXCL12 (344-FC) and BTBD3 (326-FC) ; top 10 downregulated were: EBF1 (-111-FC), HLA-DRB1(-133-FC), CPXM1 (-171-FC), LOC642131 (-171-FC), IGHV1OR15-3 (-171-FC), HLA-DRB5 (-204-FC), PRAMENP (-210-FC), DTX1 (-220-FC), CD22 (-337-FC) and RFTN1 (-356-FC). Publically available small RNA-seq data downloaded and analyzed for miRNAs, lncRNAs, circRNAs and sn/snoRNAs which contains 3 healthy donor’s plasma cells and 3 newly diagnosed myeloma patient plasma cells (PRJNA377345). We used mirDIP portal to analyze miRNA and mRNA differentially expressed data, predicated from more than 13 databases showed major role of miR-152-3p (targets 28 mRNAs), miR-93-5p (targets 19 mRNAs), miR-301a-3p (targets 13 mRNAs), miR-29c-3p (targets 12 mRNAs), and miR-144-3p (targets 9 mRNAs). Integrated analysis can provide valuable information from the transcriptomics data and effect of miRNAs on mRNAs. Citation Format: Srinivas V. Koduru. microRNA/mRNA integrated analysis of multiple myeloma transcriptomics [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2291.

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UESUGI, AARON R., MICHELLE D. DANYLUK, and LINDA J. HARRIS. "Survival of Salmonella Enteritidis Phage Type 30 on Inoculated Almonds Stored at −20, 4, 23, and 35°C." Journal of Food Protection 69, no. 8 (August 1, 2006): 1851–57. http://dx.doi.org/10.4315/0362-028x-69.8.1851.

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To evaluate the survival of Salmonella on raw almond surfaces, whole almond kernels were inoculated with Salmonella Enteritidis phage type (PT) 30 collected from a 24-h broth culture or by scraping cells from an agar lawn. Kernels inoculated with lawn-collected cells to 8, 5, 3, and 1 log CFU per almond after a 24-h drying period were stored for 161 days at 23 ± 3°C. Calculated rates of reduction were similar for the four inoculum levels (0.22, 0.28, 0.29, and 0.22 log CFU/month, respectively). Kernels inoculated to 7.1 or 8.0 log CFU per almond after drying were stored for 171 or 550 days, respectively, at selected temperatures, including −20 ± 2°C, 4 ± 2°C, 23 ± 3°C, and 35 ± 2°C. No significant reductions of Salmonella were observed during storage at −20 and 4°C over 550 days. At 35°C, a biphasic survival curve was observed, with calculated reductions of 1.1 log CFU/month from days 0 to 59 and no significant reduction from days 59 to 171. At 23°C, reductions of 0.18 and 0.30 log CFU/month were calculated for 171 and 550 days of storage, respectively. When combined with data from the study of inoculum levels, an overall average calculated reduction at 23°C was 0.25 ± 0.05 log CFU/month. Significantly greater reductions were observed during the 24-h drying period when broth-collected cells were used as the inoculum, suggesting that cells collected from agar lawns were more resistant to drying. However, after initial drying, the rates of reduction at 23°C did not differ significantly between the inoculum preparation methods. Salmonella Enteritidis PT 30 survives for long periods on almond kernels under a variety of common storage conditions.

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Kaczorowska, Katarzyna, Anna Stankiewicz, Ryszard Bugno, Maria H. Paluchowska, Grzegorz Burnat, Piotr Brański, Paulina Cieślik, et al. "Design and Synthesis of New Quinazolin-4-one Derivatives with Negative mGlu7 Receptor Modulation Activity and Antipsychotic-Like Properties." International Journal of Molecular Sciences 24, no. 3 (January 19, 2023): 1981. http://dx.doi.org/10.3390/ijms24031981.

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Following the glutamatergic theory of schizophrenia and based on our previous study regarding the antipsychotic-like activity of mGlu7 NAMs, we synthesized a new compound library containing 103 members, which were examined for NAM mGlu7 activity in the T-REx 293 cell line expressing a recombinant human mGlu7 receptor. Out of the twenty-two scaffolds examined, active compounds were found only within the quinazolinone chemotype. 2-(2-Chlorophenyl)-6-(2,3-dimethoxyphenyl)-3-methylquinazolin-4(3H)-one (A9-7, ALX-171, mGlu7 IC50 = 6.14 µM) was selective over other group III mGlu receptors (mGlu4 and mGlu8), exhibited satisfactory drug-like properties in preliminary DMPK profiling, and was further tested in animal models of antipsychotic-like activity, assessing the positive, negative, and cognitive symptoms. ALX-171 reversed DOI-induced head twitches and MK-801-induced disruptions of social interactions or cognition in the novel object recognition test and spatial delayed alternation test. On the other hand, the efficacy of the compound was not observed in the MK-801-induced hyperactivity test or prepulse inhibition. In summary, the observed antipsychotic activity profile of ALX-171 justifies the further development of the group of quinazolin-4-one derivatives in the search for a new drug candidate for schizophrenia treatment.

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Mandeville, K., J. Naheedy, E. Kettler, and Z. Boulil. "171 Presentations of Infants With Skull Fractures ≤ 3 Months of Age, With and Without Intracranial Hemorrhage." Annals of Emergency Medicine 80, no. 4 (October 2022): S77—S78. http://dx.doi.org/10.1016/j.annemergmed.2022.08.195.

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Shehata, A., and M. Abul-Dahab. "Retraction notice to “On Humbert matrix functions” [J. Egyptian Math. Soc. 20 (3) (2012) 167–171]." Journal of the Egyptian Mathematical Society 22, no. 1 (April 2014): 156. http://dx.doi.org/10.1016/j.joems.2014.02.001.

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Connell, Louise Catherine, Laura Fiedler, Shannan Dickinson, Michele Ly, Kate Harrington, William R. Jarnagin, T. Peter Kingham, et al. "Hepatic arterial infusion (HAI) chemotherapy via the medtronic pump-assessing dose delivery, response rates and toxicity." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): e16007-e16007. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e16007.

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e16007 Background: Due to the termination of the Codman pump, in order to administer hepatic arterial infusion (HAI) chemotherapy, the Medtronic pump has been used with the Codman catheter at MSKCC since 2018. Methods: Retrospective review of patients(pts) receiving HAI therapy via Medtronic pumps. Expected versus actual dose delivery of HAI FUDR, response rates and safety were reviewed. Results: Pts included; unresectable colorectal liver metastases (CRLM) (94 pts), resected CLRM (66 pts) and unresectable intrahepatic cholangiocarcinoma (ICC) (11 pts). Baseline characteristics of the 171 evaluable pts are shown in Table. In 120 pts with mCRC, 51.8% (n = 58) had 10 or more hepatic tumors and 23.2%( n = 26) had 50% or more liver involvement by metastases. 52 out of 171 pts (30.4%) had 100% of the expected FUDR doses by completion of the 3rdcycle. Another 49.7% (85/171) had greater than or equal to 50% of the expected FUDR dose. 96 pts had measurable disease (unresectable CLRM and ICC subgroups) evaluated by RECIST 1.1 with an MSK radiologist. The partial response for unresectable CRLM pts was 47% (41/87), and 28% (24/87) were stable. The partial response for ICC pts was 22% (2/9), and 33% (3/9) were stable. Conclusions: We evaluated 171 pts who were heavily pretreated and had extensive disease prior to pump placement. Partial response by RECIST 1.1 of 47% was evident in those pts with CRLM and 22% for pts with ICC. Dose delivery of HAI FUDR was compatible with that seen with the Codman pump and no increase in toxicity was noted. An updated analysis with additional evaluable pts will be presented at the meeting. [Table: see text]

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Chen, Si-liang, Peng Hu, Zhi-peng Lin, and Jian-bo Zhao. "The Effect of Puncture Sites of Portal Vein in TIPS with ePTFE-Covered Stents on Postoperative Long-Term Clinical Efficacy." Gastroenterology Research and Practice 2019 (January 9, 2019): 1–11. http://dx.doi.org/10.1155/2019/2935498.

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Purpose. To evaluate the effect of puncture sites of the portal vein in transjugular intrahepatic portosystemic shunt (TIPS) on long-term clinical efficacy. Methods. A retrospective review was performed, including consecutive 171 patients who underwent TIPS with ePTFE-covered stents. All patients were divided into 3 groups according to the puncture site of the portal vein: intrahepatic bifurcation of the portal vein (group A, n=88), right branch of the portal vein (group B, n=48), and left branch of the portal vein (group C, n=35). The Kaplan-Meier analysis was performed to assess the effect of different puncture sites on primary patency, the incidence of hepatic encephalopathy (HE), and survival. Results. The primary restenosis rate was 29.8% (51/171). The total HE rate was 31.6% (54/171). The cumulative death rate was 19.3% (33/171). The Kaplan-Meier analysis showed that group C versus group A, group C versus group B, and group A versus group B were significantly different on the primary restenosis rate, respectively (χ2 = 11.49, P=0.001; χ2 = 4.54, P=0.033; and χ2 = 4.12, P=0.046), and group C is better than the other two groups. What is more, group C versus group A and group C versus group B were significantly different on the incidence of HE, respectively (χ2 = 8.07, P=0.004; χ2 = 9.44, P=0.002), and group C is better than the other two groups. There was no significant difference on survival. Conclusion. Choosing the left branch of the portal vein as the puncture site to create the shunt in TIPS with ePTFE-covered stents may decrease the incident of primary restenosis and HE significantly.

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