Journal articles on the topic '12C Beam fragmentation'
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Gunzert-Marx, K., D. Schardt, and R. S. Simon. "Fast neutrons produced by nuclear fragmentation in treatment irradiations with 12C beam." Radiation Protection Dosimetry 110, no. 1-4 (August 1, 2004): 595–600. http://dx.doi.org/10.1093/rpd/nch138.
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Duan, Hai-Rui, Jing-Ya Wu, Tian-Li Ma, Jun-Sheng Li, Hui-Ling Li, Ming-Ming Xu, Rui-Xia Yang, et al. "Fragmentation of carbon on elemental targets at 290AMeV." International Journal of Modern Physics E 30, no. 06 (June 2021): 2150046. http://dx.doi.org/10.1142/s0218301321500464.
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The total charge-changing cross-sections and the partial cross-sections for projectile fragments (PFs) production for the fragmentation of 12C on C, Al, Cu, Pb and CH2 targets at the highest energy of 290[Formula: see text]A[Formula: see text]MeV were studied. It was found that the total charge-changing reaction cross-sections and the partial reaction cross-sections of PFs production were independent of the beam energy, and increased with increase of mass of target for the same beam energy. The total charge-changing reaction cross-section was the same as the prediction of Bradt–Peters semi-empirical formula, PHITS and NUCFRG2 simulation models. The partial cross-section of PFs production increased with the increase of the mass of target, and it was the same as the prediction of NUCFRG2 models. The mean scattering angle of projectile particle was smaller than the average emission angle of PF, and the width of scattering angle distribution of projectile particle was smaller than that of emission angle distribution of PFs. The mean emission angle of PFs does not obviously depend on the target mass and beam energy in our studied beam energy regions.
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Ounoughi, Nabil, Yamina Dribi, Abdelmalek Boukhellout, and Faycal Kharfi. "Physical aspects of Bragg curve of therapeutic oxygen-ion beam: Monte Carlo simulation." Polish Journal of Medical Physics and Engineering 28, no. 3 (September 1, 2022): 160–68. http://dx.doi.org/10.2478/pjmpe-2022-0019.
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Abstract Introduction: Oxygen (16O) ion beams have been recommended for cancer treatment due to its physical Bragg curve feature and biological property. The goal of this research is to use Monte Carlo simulation to analyze the physical features of the 16O Bragg curve in water and tissue. Material and methods: In order to determine the benefits and drawbacks of ion beam therapy, Monte Carlo simulation (PHITS code) was used to investigate the interaction and dose deposition properties of oxygen ions beam in water and human tissue medium. A benchmark study for the depth–dose distribution of a 16O ion beam in a water phantom was established using the PHITS code. Bragg’s peak location of 16O ions in water was simulated using the effect of water’s mean ionization potential. The contribution of secondary particles produced by nuclear fragmentation to the total dose has been calculated. The depth and radial dose profiles of 16O, 12C, 4He, and 1H beams were compared. Results: It was shown that PHITS accurately reproduces the measured Bragg curves. The mean ionization potential of water was estimated. It has been found that secondary particles contribute 10% behind the Bragg peak for 16O energy of 300 MeV/u. The comparison of the depth and radial dose profiles of 16O, 12C, 4He, and 1H beams, shows clearly, that the oxygen beam has the greater deposited dose at Bragg peak and the minor lateral deflection. Conclusions: The combination of these physical characteristics with radio-biological ones in the case of resistant organs located behind the tumor volume, leads to the conclusion that the 16O ion beams can be used to treat deep-seated hypoxic tumors.
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Farés, G., R. Bimbot, S. Hachem, M. Mirea, R. Anne, T. Benfoughal, C. Cabot, et al. "Fragmentation of 95 MeV/u 12C and 75 MeV/u 13C. Application to secondary-beam production." European Physical Journal A 19, no. 1 (January 2004): 105–16. http://dx.doi.org/10.1140/epja/i2002-10247-9.
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Ghorai, Atanu, Nitai P. Bhattacharyya, Asitikantha Sarma, and Utpal Ghosh. "Radiosensitivity and Induction of Apoptosis by High LET Carbon Ion Beam and Low LET Gamma Radiation: A Comparative Study." Scientifica 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/438030.
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Cancer treatment with high LET heavy ion beam, especially, carbon ion beam (12C), is becoming very popular over conventional radiotherapy like low LET gamma or X-ray. Combination of Poly(ADP-ribose) polymerase (PARP) inhibitor with xenotoxic drugs or conventional radiation (gamma or X-ray) is the newer approach for cancer therapy. The aim of our study was to compare the radiosensitivity and induction of apoptosis by high LET12C and low LET gamma radiation in HeLa and PARP-1 knocked down cells. We did comet assay to detect DNA breaks, clonogenic survival assay, and cell cycle analysis to measure recovery after DNA damage. We measured apoptotic parameters like nuclear fragmentation and caspase-3 activation. DNA damage, cell killing, and induction of apoptosis were significantly higher for12C than gamma radiation in HeLa. Cell killing and apoptosis were further elevated upon knocking down of PARP-1. Both12C and gamma induced G2/M arrest although the12C had greater effect. Unlike the gamma,12C irradiation affects DNA replication as detected by S-phase delay in cell cycle analysis. So, we conclude that high LET12C has greater potential over low LET gamma radiation in killing cells and radiosensitization upon PARP-1 inhibition was several folds greater for12C than gamma.
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Haettner, E., H. Iwase, and D. Schardt. "Experimental fragmentation studies with 12C therapy beams." Radiation Protection Dosimetry 122, no. 1-4 (December 1, 2006): 485–87. http://dx.doi.org/10.1093/rpd/ncl402.
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Kirkby, Karen Joy, Norman Francis Kirkby, Neil Gunn Burnet, Hywel Owen, Ranald Iain Mackay, Adrian Crellin, and Stuart Green. "Heavy charged particle beam therapy and related new radiotherapy technologies: The clinical potential, physics and technical developments required to deliver benefit for patients with cancer." British Journal of Radiology 93, no. 1116 (December 1, 2020): 20200247. http://dx.doi.org/10.1259/bjr.20200247.
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In the UK, one in two people will develop cancer during their lifetimes and radiotherapy (RT) plays a key role in effective treatment. High energy proton beam therapy commenced in the UK National Health Service in 2018. Heavier charged particles have potential advantages over protons by delivering more dose in the Bragg peak, with a sharper penumbra, lower oxygen dependence and increased biological effectiveness. However, they also require more costly equipment including larger gantries to deliver the treatment. There are significant uncertainties in the modelling of relative biological effectiveness and the effects of the fragmentation tail which can deliver dose beyond the Bragg peak. These effects need to be carefully considered especially in relation to long-term outcomes. In 2019, a group of clinicians, clinical scientists, engineers, physical and life scientists from academia and industry, together with funding agency stakeholders, met to consider how the UK should address new technologies for RT, especially the use of heavier charged particles such as helium and carbon and new modes of delivery such as FLASH and spatially fractionated radiotherapy (SFRT). There was unanimous agreement that the UK should develop a facility for heavier charged particle therapy, perhaps constituting a new National Ion Research Centre to enable research using protons and heavier charged particles. Discussion followed on the scale and features, including which ions should be included, from protons through helium, boron, and lithium to carbon, and even oxygen. The consensus view was that any facility intended to treat patients must be located in a hospital setting while providing dedicated research space for physics, preclinical biology and clinical research with beam lines designed for both in vitro and in vivo research. The facility should to be able to investigate and deliver both ultra-high dose rate FLASH RT and SFRT (GRID, minibeams etc.). Discussion included a number of accelerator design options and whether gantries were required. Other potential collaborations might be exploited, including with space agencies, electronics and global communications industries and the nuclear industry. In preparation for clinical delivery, there may be opportunities to send patients overseas (for 12C or 4He ion therapy) using the model of the National Health Service (NHS) Proton Overseas Programme and to look at potential national clinical trials which include heavier ions, FLASH or SFRT. This could be accomplished under the auspices of NCRI CTRad (National Cancer Research Institute, Clinical and Translational Radiotherapy Research Working Group). The initiative should be a community approach, involving all interested parties with a vision that combines discovery science, a translational research capability and a clinical treatment facility. Barriers to the project and ways to overcome them were discussed. Finally, a set of different scenarios of features with different costs and timelines was constructed, with consideration given to the funding environment (prer-Covid-19) and need for cross-funder collaboration.
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TRAUTMANN, W., P. ADRICH, T. AUMANN, C. O. BACRI, T. BARCZYK, R. BASSINI, S. BIANCHIN, et al. "N/Z DEPENDENCE OF PROJECTILE FRAGMENTATION." International Journal of Modern Physics E 17, no. 09 (October 2008): 1838–49. http://dx.doi.org/10.1142/s0218301308010829.
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The N/Z dependence of projectile fragmentation at relativistic energies has been studied in a recent experiment at the GSI laboratory with the ALADiN forward spectrometer coupled to the LAND neutron detector. Besides a primary beam of 124 Sn , also secondary beams of 124 La and 107 Sn delivered by the FRS fragment separator have been used in order to extend the range of isotopic compositions of the produced spectator sources. With the achieved mass resolution of ΔA/A ≈ 1.5%, lighter isotopes with atomic numbers Z ≤ 10 are individually resolved. The presently ongoing analyses of the measured isotope yields focus on isoscaling and its relation to the properties of hot fragments at freeze-out and on the derivation of chemical freeze-out temperatures which are found to be independent of the isotopic composition of the studied systems. The latter result is at variance with the predictions for limiting temperatures as obtained with finite-temperature Hartree-Fock calculations.
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Lazzeroni, M., and A. Brahme. "24 11C POSITRON EMITTER BEAMS PRODUCED BY 12C PROJECTILE FRAGMENTATION FOR IMPROVED ACCURACY IN DOSE DELIVERY VERIFICATION." Radiotherapy and Oncology 102 (March 2012): S5—S6. http://dx.doi.org/10.1016/s0167-8140(12)70011-7.
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Lazzeroni, Marta, and Anders Brahme. "Effective source size, radial, angular and energy spread of therapeutic 11C positron emitter beams produced by 12C fragmentation." Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 320 (February 2014): 26–36. http://dx.doi.org/10.1016/j.nimb.2013.12.004.
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STEER, S. J., ZS PODOLYÁK, S. PIETRI, M. GÓRSKA, G. F. FARRELLY, P. H. REGAN, D. RUDOLPH, et al. "ISOMERIC DECAY STUDIES IN NEUTRON-RICH N ≈ 126 NUCLEI." International Journal of Modern Physics E 18, no. 04 (April 2009): 1002–7. http://dx.doi.org/10.1142/s0218301309013154.
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Heavy neutron-rich nuclei were populated via relativistic energy fragmentation of a E / A = 1 GeV 208 Pb beam. The nuclei of interest were selected and identified by a fragment separator and then implanted in a passive plastic stopper. Delayed γ rays following internal isomeric decays were detected by the RISING array. Experimental information was obtained on a number of nuclei with Z = 73-80 ( Ta - Hg ), providing new information both on the prolate-oblate transitional region as well as on the N = 126 closed shell nuclei.
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Srivastav, Sumit, and Bhas Bapat. "Post collision analyzer to study charge-exchange processes in ion-molecule collisions." Review of Scientific Instruments 93, no. 11 (November 1, 2022): 113306. http://dx.doi.org/10.1063/5.0121351.
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We have designed an electrostatic charge state analyzer for ion beams having energies in the range of 5–20 keV/ q. It is primarily built to investigate the different ionization processes involved in the slow ( v < 1 a.u.) impact of highly charged ions on molecules. The analyzer is a cylindrical deflector analyzer (CDA) based on a pair of concentric cylindrical sectors of radii 110.2 and 95 mm, subtending an angle of 127° at its center. Additionally, an Einzel lens and a quadrupole deflector are deployed to focus and steer the ion beam. The compact design of the analyzer permits easy integration with an ion momentum spectrometer used for studying the fragmentation of the target molecules. The characterization of the CDA including its calibration and its transmission function is carried out using an ion beam delivered from an electron beam ion source. To check the performance of the setup, we have carried out experiments comprising the impact of Ar16+ projectiles on CO2 target molecules at an energy of 18 keV/ q. With the help of the CDA, different charge exchange ionization processes, such as single capture, double capture, and triple capture of electrons by the projectile ion have been separated efficiently. The possibility of a modification in the geometry of CDA is discussed to further improve its performance.
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TRAUTMANN, W., S. BIANCHIN, A. S. BOTVINA, A. LE FÈVRE, Y. LEIFELS, C. SFIENTI, N. BUYUKCIZMECI, et al. "THE SYMMETRY ENERGY IN NUCLEAR REACTIONS." International Journal of Modern Physics E 19, no. 08n09 (September 2010): 1653–63. http://dx.doi.org/10.1142/s0218301310016077.
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New results for the strength of the symmetry energy are presented which illustrate the complementary aspects encountered in reactions probing nuclear densities below and above saturation. A systematic study of isotopic effects in spectator fragmentation was performed at the ALADIN spectrometer with 124 Sn primary and 107 Sn and 124 La secondary beams of 600 MeV/nucleon incident energy. The analysis within the Statistical Fragmentation Model shows that the symmetry-term coefficient entering the liquid-drop description of the emerging fragments decreases significantly as the multiplicity of fragments and light particles from the disintegration of the produced spectator systems increases. Higher densities were probed in the FOPI/LAND study of nucleon and light-particle flows in central and mid-peripheral collisions of 197 Au +197 Au nuclei at 400 MeV/nucleon incident energy. From the comparison of the measured neutron and hydrogen squeeze-out ratios with predictions of the UrQMD model a moderately soft symmetry term with a density dependence of the potential term proportional to (ρ/ρ0)γ with γ = 0.9 ± 0.3 is favored.
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Behrendt, M., M. Schartmann, and A. Burkert. "The possible hierarchical scales of observed clumps in high-redshift disc galaxies." Monthly Notices of the Royal Astronomical Society 488, no. 1 (June 21, 2019): 306–23. http://dx.doi.org/10.1093/mnras/stz1717.
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ABSTRACTGiant clumps on ∼kpc scales and with masses of $10^8\rm {-}10^9 \, \mathrm{M_{\odot }}$ are ubiquitous in observed high-redshift disc galaxies. Recent simulations and observations with high spatial resolution indicate the existence of substructure within these clumps. We perform high-resolution simulations of a massive galaxy to study the substructure formation within the framework of gravitational disc instability. We focus on an isolated and pure gas disc with an isothermal equation of state with T = 104 K that allows capturing the effects of self-gravity and hydrodynamics robustly. The main mass of the galaxy resides in rotationally supported clumps which grow by merging to a maximum clump mass of $10^8 \, \mathrm{M_{\odot }}$ with diameter ∼120 pc for the dense gas. They group to clump clusters (CCs) within relatively short times ($\ll 50 \, \mathrm{Myr}$), which are present over the whole simulation time. We identify several mass and size scales on which the clusters appear as single objects at the corresponding observational resolution between ${\sim } 10^8 \,\rm{and}\, 10^9 \, \mathrm{M_{\odot }}$. Most of the clusters emerge as dense groups and for larger beams they are more likely to be open structures represented by a single object. In the high-resolution runs higher densities can be reached, and the initial structures can collapse further and fragment to many clumps smaller than the initial Toomre length. In our low-resolution runs, the clumps directly form on larger scales 0.3–1 kpc with $10^8\rm {-}10^9 \, \mathrm{M_{\odot }}$. Here, the artificial pressure floor which is typically used to prevent spurious fragmentation strongly influences the initial formation of clumps and their properties at very low densities.
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Grzegorczyk, Adrian, and Marcin Mamajek. "A 70 W thulium-doped all-fiber laser operating at 1940 nm." Photonics Letters of Poland 11, no. 3 (September 30, 2019): 81. http://dx.doi.org/10.4302/plp.v11i3.928.
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An all-fiber thulium-doped fiber laser operating at a wavelength of 1940 nm is reported. A maximum output continuous-wave power of 70.7 W with a slope efficiency of 59%, determined with respect to the absorbed pump power, was demonstrated. The laser delivered almost a single-mode beam with a beam quality factor of < 1.3.Full Text: PDF ReferencesM. N. Zervas and C. A. Codemard, "High Power Fiber Lasers: A Review", IEEE J. Sel. Top. Quantum Electron. 20, 0904123 (2014). CrossRef D. J. Richardson, J. Nilsson, and W. A. Clarkson. "High power fiber lasers: current status and future perspectives [Invited]", J. Opt. Soc. Am. B 27, B63 (2010). CrossRef J. Swiderski, A. Zajac, and M. Skorczakowski, "Pulsed ytterbium-doped large mode area double-clad fiber amplifier in MOFPA configuration", Opto-Electron. Rev. 15, 98 (2007). CrossRef M. Eckerle et al. "High-average-power actively-modelocked Tm3+ fiber lasers", Proc. SPIE 8237, 823740 (2012). CrossRef J. Swiderski, D. Dorosz, M. Skorczakowski, and W. Pichola, "Ytterbium-doped fiber amplifier with tunable repetition rate and pulse duration", Laser Phys. 20, 1738 (2010). CrossRef P. Grzes and J. Swiderski, "Gain-Switched 2-μm Fiber Laser System Providing Kilowatt Peak-Power Mode-Locked Resembling Pulses and Its Application to Supercontinuum Generation in Fluoride Fibers", IEEE Phot. J. 10, 1 (2018). CrossRef S. Liang et al. "Transmission of wireless signals using space division multiplexing in few mode fibers", Opt. Express 26, 6490 (2018). CrossRef J. Swiderski, M. Michalska, and P. Grzes, "Broadband and top-flat mid-infrared supercontinuum generation with 3.52 W time-averaged power in a ZBLAN fiber directly pumped by a 2-µm mode-locked fiber laser and amplifier", Appl. Phys. B 124, 152 (2018). CrossRef F. Zhao et al. "Electromagnetically induced polarization grating", Sci. Rep. 8, 16369 (2018). CrossRef J. Sotor et al. "Ultrafast thulium-doped fiber laser mode locked with black phosphorus", Opt. Lett. 40, 3885 (2015). CrossRef M. Olivier et al. "Femtosecond fiber Mamyshev oscillator at 1550 nm", Opt. Lett. 44, 851 (2019). CrossRef J. Swiderski and M. Michalska, "Over three-octave spanning supercontinuum generated in a fluoride fiber pumped by Er & Er:Yb-doped and Tm-doped fiber amplifiers", Opt. Laser Technol. 52, 75 (2013). CrossRef C.Yao et al. "High-power mid-infrared supercontinuum laser source using fluorotellurite fiber", Optica 5, 1264 (2018). CrossRef J. Swiderski and M. Maciejewska, "Watt-level, all-fiber supercontinuum source based on telecom-grade fiber components", Appl. Phys. B 109, 177 (2012). CrossRef O. Traxer and E. X. Keller, "Thulium fiber laser: the new player for kidney stone treatment? A comparison with Holmium:YAG laser", World J. Urol., 1-12 (2019). CrossRef M. Michalska, et al. "Highly stable, efficient Tm-doped fiber laser—a potential scalpel for low invasive surgery", Laser Phys. Lett. 13, 115101 (2016). CrossRef R. L. Blackmon et al. "Thulium fiber laser ablation of kidney stones using a 50-μm-core silica optical fiber", Opt. Eng., 54, 011004 (2015). CrossRef A. Zajac et al. "Fibre lasers – conditioning constructional and technological", Bull. Pol. Ac.: Tech. 58, 491 (2010). CrossRef C. Guo, D. Shen, J. Long, and F. Wang, "High-power and widely tunable Tm-doped fiber laser at 2 \mu m", Chin. Opt. Lett. 10, 091406 (2012). CrossRef F. Liu et al. "Tandem-pumped, tunable thulium-doped fiber laser in 2.1 μm wavelength region", Opt. Express 27, 8283 (2019). CrossRef H. Ahmad, M. Z. Samion, K. Thambiratnam, and M. Yasin, "Widely Tunable Dual-Wavelength Thulium-doped fiber laser Operating in 1.8-2.0 mm Region", Optik 179, 76 (2019). CrossRef N. M. Fried, "Thulium fiber laser lithotripsy: An in vitro analysis of stone fragmentation using a modulated 110‐watt Thulium fiber laser at 1.94 µm", Lasers Surg. Med. 37, 53 (2005). CrossRef N. M. Fried, "High‐power laser vaporization of the canine prostate using a 110 W Thulium fiber laser at 1.91 μm", Lasers Surg. Med. 36, 52 (2005). CrossRef E. Lippert et al. "Polymers Designed for Laser Applications-Fundamentals and Applications", Proc. SPIE 6397, P639704 (2006). CrossRef N. Dalloz et al. "High power Q-switched Tm3+, Ho3+-codoped 2μm fiber laser and application for direct OPO pumping", Proc. SPIE 10897, 108970J (2019). CrossRef N. J. Ramírez-Martinez, M. Nunez-Velazquez, A. A. Umnikov, and J. K. Sahu, "Highly efficient thulium-doped high-power laser fibers fabricated by MCVD", Opt. Express 27, 196 (2019). CrossRef T. Ehrenreich et al. "1-kW, All-Glass Tm:fiber Laser", Proc. SPIE 7580, 758016 (2010). DirectLink L. Shah et al. "Integrated Tm:fiber MOPA with polarized output and narrow linewidth with 100 W average power", Opt. Express 20, 20558 (2012). CrossRef H. Zhen-Yue, Y. Ping, X. Qi-Rong, L. Qiang, and G. Ma-Li, "227-W output all-fiberized Tm-doped fiber laser at 1908 nm", Chin. Phys. B 23, 104206 (2014). CrossRef
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Battistoni, Giuseppe, Marco Toppi, Vincenzo Patera, and The FOOT Collaboration. "Measuring the Impact of Nuclear Interaction in Particle Therapy and in Radio Protection in Space: the FOOT Experiment." Frontiers in Physics 8 (February 8, 2021). http://dx.doi.org/10.3389/fphy.2020.568242.
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In Charged Particle Therapy (PT) proton or 12C beams are used to treat deep-seated solid tumors exploiting the advantageous characteristics of charged particles energy deposition in matter. For such projectiles, the maximum of the dose is released at the end of the beam range, in the Bragg peak region, where the tumour is located. However, the nuclear interactions of the beam nuclei with the patient tissues can induce the fragmentation of projectiles and/or target nuclei and needs to be carefully taken into account when planning the treatment. In proton treatments, the target fragmentation produces low energy, short range fragments along all the beam path, that deposit a non-negligible dose especially in the first crossed tissues. On the other hand, in treatments performed using 12C, or other (4He or 16O) ions of interest, the main concern is related to the production of long range fragments that can release their dose in the healthy tissues beyond the Bragg peak. Understanding nuclear fragmentation processes is of interest also for radiation protection in human space flight applications, in view of deep space missions. In particular 4He and high-energy charged particles, mainly 12C, 16O, 28Si and 56Fe, provide the main source of absorbed dose in astronauts outside the atmosphere. The nuclear fragmentation properties of the materials used to build the spacecrafts need to be known with high accuracy in order to optimise the shielding against the space radiation. The study of the impact of these processes, which is of interest both for PT and space radioprotection applications, suffers at present from the limited experimental precision achieved on the relevant nuclear cross sections that compromise the reliability of the available computational models. The FOOT (FragmentatiOn Of Target) collaboration, composed of researchers from France, Germany, Italy and Japan, designed an experiment to study these nuclear processes and measure the corresponding fragmentation cross sections. In this work we discuss the physics motivations of FOOT, describing in detail the present detector design and the expected performances, coming from the optimization studies based on accurate FLUKA MC simulations and preliminary beam test results. The measurements planned will be also presented.
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Toppi, Marco, Guido Baroni, Giuseppe Battistoni, Maria Giuseppina Bisogni, Piergiorgio Cerello, Mario Ciocca, Patrizia De Maria, et al. "Monitoring Carbon Ion Beams Transverse Position Detecting Charged Secondary Fragments: Results From Patient Treatment Performed at CNAO." Frontiers in Oncology 11 (June 10, 2021). http://dx.doi.org/10.3389/fonc.2021.601784.
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Particle therapy in which deep seated tumours are treated using 12C ions (Carbon Ions RadioTherapy or CIRT) exploits the high conformity in the dose release, the high relative biological effectiveness and low oxygen enhancement ratio of such projectiles. The advantages of CIRT are driving a rapid increase in the number of centres that are trying to implement such technique. To fully profit from the ballistic precision achievable in delivering the dose to the target volume an online range verification system would be needed, but currently missing. The 12C ions beams range could only be monitored by looking at the secondary radiation emitted by the primary beam interaction with the patient tissues and no technical solution capable of the needed precision has been adopted in the clinical centres yet. The detection of charged secondary fragments, mainly protons, emitted by the patient is a promising approach, and is currently being explored in clinical trials at CNAO. Charged particles are easy to detect and can be back-tracked to the emission point with high efficiency in an almost background-free environment. These fragments are the product of projectiles fragmentation, and are hence mainly produced along the beam path inside the patient. This experimental signature can be used to monitor the beam position in the plane orthogonal to its flight direction, providing an online feedback to the beam transverse position monitor chambers used in the clinical centres. This information could be used to cross-check, validate and calibrate, whenever needed, the information provided by the ion chambers already implemented in most clinical centres as beam control detectors. In this paper we study the feasibility of such strategy in the clinical routine, analysing the data collected during the clinical trial performed at the CNAO facility on patients treated using 12C ions and monitored using the Dose Profiler (DP) detector developed within the INSIDE project. On the basis of the data collected monitoring three patients, the technique potential and limitations will be discussed.
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De Simoni, Micol, Giuseppe Battistoni, Angelica De Gregorio, Patrizia De Maria, Marta Fischetti, Gaia Franciosini, Michela Marafini, et al. "A Data-Driven Fragmentation Model for Carbon Therapy GPU-Accelerated Monte-Carlo Dose Recalculation." Frontiers in Oncology 12 (March 25, 2022). http://dx.doi.org/10.3389/fonc.2022.780784.
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The advent of Graphics Processing Units (GPU) has prompted the development of Monte Carlo (MC) algorithms that can significantly reduce the simulation time with respect to standard MC algorithms based on Central Processing Unit (CPU) hardware. The possibility to evaluate a complete treatment plan within minutes, instead of hours, paves the way for many clinical applications where the time-factor is important. FRED (Fast paRticle thErapy Dose evaluator) is a software that exploits the GPU power to recalculate and optimise ion beam treatment plans. The main goal when developing the FRED physics model was to balance accuracy, calculation time and GPU execution guidelines. Nowadays, FRED is already used as a quality assurance tool in Maastricht and Krakow proton clinical centers and as a research tool in several clinical and research centers across Europe. Lately the core software has been updated including a model of carbon ions interactions with matter. The implementation is phenomenological and based on carbon fragmentation data currently available. The model has been tested against the MC FLUKA software, commonly used in particle therapy, and a good agreement was found. In this paper, the new FRED data-driven model for carbon ion fragmentation will be presented together with the validation tests against the FLUKA MC software. The results will be discussed in the context of FRED clinical applications to 12C ions treatment planning.
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Norbury, John W., Giuseppe Battistoni, Judith Besuglow, Luca Bocchini, Daria Boscolo, Alexander Botvina, Martha Clowdsley, et al. "Are Further Cross Section Measurements Necessary for Space Radiation Protection or Ion Therapy Applications? Helium Projectiles." Frontiers in Physics 8 (November 30, 2020). http://dx.doi.org/10.3389/fphy.2020.565954.
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The helium (4He) component of the primary particles in the galactic cosmic ray spectrum makes significant contributions to the total astronaut radiation exposure. 4He ions are also desirable for direct applications in ion therapy. They contribute smaller projectile fragmentation than carbon (12C) ions and smaller lateral beam spreading than protons. Space radiation protection and ion therapy applications need reliable nuclear reaction models and transport codes for energetic particles in matter. Neutrons and light ions (1H, 2H, 3H, 3He, and 4He) are the most important secondary particles produced in space radiation and ion therapy nuclear reactions; these particles penetrate deeply and make large contributions to dose equivalent. Since neutrons and light ions may scatter at large angles, double differential cross sections are required by transport codes that propagate radiation fields through radiation shielding and human tissue. This work will review the importance of 4He projectiles to space radiation and ion therapy, and outline the present status of neutron and light ion production cross section measurements and modeling, with recommendations for future needs.
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Orozco-Flores, Alonso A., José A. Valadez-Lira, Karina E. Covarrubias-Cárdenas, José J. Pérez-Trujillo, Ricardo Gomez-Flores, Diana Caballero-Hernández, Reyes Tamez-Guerra, Cristina Rodríguez-Padilla, and Patricia Tamez-Guerra. "In vitro antitumor, pro-inflammatory, and pro-coagulant activities of Megalopyge opercularis J.E. Smith hemolymph and spine venom." Scientific Reports 10, no. 1 (October 27, 2020). http://dx.doi.org/10.1038/s41598-020-75231-1.
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Abstract Contact with stinging spines venom from several Lepidoptera larvae may result in skin lesions. In Mexico, envenomation outbreaks caused by Megalopyge opercularis were reported between 2015 and 2016. The aim of this study was to identify the venomous caterpillars in Nuevo Leon, Mexico and evaluate several biological activities of their hemolymph (HEV) and spine setae (SSV) venoms. M. opercularis was identified by cytochrome oxidase subunit (COI) designed primers. HEV and SSV extracts cytotoxic activity was assessed on the L5178Y-R lymphoma cell line. For apoptotic cells number and apoptosis, cells were stained with acridine orange/ethidium bromide and validated by DNA fragmentation. Human peripheral blood mononuclear cells (hPBMC) cytokine response to the extracts was measured by the cytometric bead array assay. Extracts effect on pro-coagulation activity on human plasma was also evaluated. HEV and SSV extracts significantly inhibited (p < 0.01) up to 63% L5178Y-R tumor cell growth at 125–500 µg/mL, as compared with 43% of Vincristine. About 79% extracts-treated tumor cells death was caused by apoptosis. Extracts stimulated (p < 0.01) up to 60% proliferation of resident murine lymphocytes, upregulated IL-1β, IL-6, IL-8, and TNF-α production by hPBMC, and showed potent pro-coagulant effects. The pharmacological relevance of these venoms is discussed.
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Argenziano, Mariana, jiajia yang, Mariana Burgos Angulo, and Thomas V. McDonald. "Abstract P309: Particulate Matter Increases Oxidative Stress And Shortens The Action Potential In IPS-derived Cardiomyocytes." Circulation Research 129, Suppl_1 (September 3, 2021). http://dx.doi.org/10.1161/res.129.suppl_1.p309.
Full textAbstract:
Introduction: Air particulate matter (PM) represents one of the most critical environmental issues worldwide, causing more than 3 million deaths a year. In the US, hospital admissions due to heart failure (HF) increase by 0.8% for every 10 μg/m3 elevation in PM. However, the biological mechanisms behind the effects of PM on cardiovascular disease (CVD) remain poorly defined. Recent studies showed that PM 2.5 can translocate into the circulation, causing cumulative toxicity. With air pollution increasing due to human activity and the growing prevalence of HF, there is a critical need to understand PM's contributions to CVD to develop preventive treatments and novel therapeutic approaches. Hypothesis: We hypothesize that PM can exert its toxic effect by increasing oxidative stress and apoptosis and affecting cardiac electrophysiology. Methods: Three independent induced pluripotent stem cell lines (IPSC) were differentiated into cardiomyocytes (iCMs) and cultured for 30 days before treatment with 100 μg/ml of PM 2.5 for 48h. Experiments including immunostaining, qPCR, RNAseq and Multielectrode Array (MEA) were performed in control (CT) and PM-treated iCMs (PM). Results: Treatment with PM increased ROS and decreased ATP production (CT 9.9±1.2pmol vs PM 6.6±0.8pmol, p<0.01, n=20). Immunostaining showed mitochondrial fragmentation and increased expression of cleaved caspase3 without structural changes. Moreover, PM caused upregulation of the apoptotic markers P53 , PARP1 and CASP3, oxidative stress markers CYP1A1, CYP1B1 and MT2A, and cardiac markers CACNA1C together with downregulation of GJA1 . RNAseq analysis showed upregulation of Gene Ontology terms related to detoxification, response to toxic substances and oxidative stress. Upregulated KEGG pathways included oxidative phosphorylation, hypertrophic cardiomyopathy and dilated cardiomyopathy. MEA experiments revealed a decrease in the spike amplitude and conduction velocity, along with shortening of the action potential (APD90: CT 577±20ms vs. PM 489±16ms, p<0.05, n=20) and increased beat period irregularity (CT 3.2±0.7% vs. PM 13.1±1.6%, p<0.001, n=20). These electrophysiological changes were reversed by treatment with the antioxidant N-acetylcysteine. Conclusions: We conclude that PM plays a direct role in the development of CVD, causing an increase in oxidative stress and affecting the electrophysiology of the heart. Further functional studies in iCMs from HF patients will provide evidence of the effects of these changes on the phenotype of the disease.