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Academic literature on the topic '0941'

Author: Grafiati

Published: 25 July 2024

Last updated: 28 July 2024

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Journal articles on the topic "0941"

Fouda, A. S., M. A. Ismail, A. S. Abousalem, and G. Y. Elewady. "Experimental and theoretical studies on corrosion inhibition of 4-amidinophenyl-2,2′-bifuran and its analogues in acidic media." RSC Adv. 7, no. 73 (2017): 46414–30. http://dx.doi.org/10.1039/c7ra08092a.

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Corrosion inhibition studies of carbon steel (CS) in 1 M HCl by newly synthesized bichalcophene compounds namely; 4-(2,2′-bifuran-5-yl)benzamidine (MA-0947) and 6-(2,2′-bifuran-5-yl)nicotinamidine (MA-0941) and 6-[5-(thiophen-2-yl)furan-2-yl]nicotinamidine (MA-0940).

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Thriveni*, M. C., Raju Mondal, G. Thanavendan, G. Ravikumar, and B. T. Sreenivasa. "Characterization of Mulberry Genetic Resources for Multiple Traits." Indian Journal of Botany 1, no. 2 (October 10, 2021): 8–15. http://dx.doi.org/10.35940/ijb.b2004.101221.

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Mulberry plants have wide range of variations in characters in view of its adaptability to cross pollination with no inter-specific reproduction barrier rendering it a heterozygous species. Every plant being different from the other in natural population, this great diversity makes it difficult to gather information and carry out studies on effect of different edaphic factors on the expression of genotypic characters for adjudging the variations. In lieu of this known diversity for posterity, the collection of mulberry genotypes from diverse genetic sources, their conservation, evaluation and consequent documentation is of prime importance. In the present study, 69 mulberry accessions were characterized for morphology, anatomy, and reproductive parameters. Evaluation for propagation, growth and yield characters were also carried out. Based on multiple trait analysis, 14 top performing accessions viz., MI-0879, MI-0882, MI-0908, MI-0931, MI-0907, MI-0940, MI-0881, MI-0941, MI0892, MI-0913, MI-0937, MI-0934, MI-0865, MI-0886 were identified. These accessions could serve as resources for further evaluation aimed at trait-specific crop improvement.

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Yang, Hongqin, Yanjun Ma, Hongjie Zhang, and Junyi Ma. "PI3K/mTOR Dual Inhibitor Pictilisib Stably Binds to Site I of Human Serum Albumin as Observed by Computer Simulation, Multispectroscopic, and Microscopic Studies." Molecules 27, no. 16 (August 9, 2022): 5071. http://dx.doi.org/10.3390/molecules27165071.

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Pictilisib (GDC-0941) is a well-known dual inhibitor of class I PI3K and mTOR and is presently undergoing phase 2 clinical trials for cancer treatment. The present work investigated the dynamic behaviors and interaction mechanism between GDC-0941 and human serum albumin (HSA). Molecular docking and MD trajectory analyses revealed that GDC-0941 bound to HSA and that the binding site was positioned in subdomain IIA at Sudlow’s site I of HSA. The fluorescence intensity of HSA was strongly quenched by GDC-0941, and results showed that the HSA–GDC-0941 interaction was a static process caused by ground-state complex formation. The association constant of the HSA–GDC-0941 complex was approximately 105 M−1, reflecting moderate affinity. Thermodynamic analysis conclusions were identical with MD simulation results, which revealed that van der Waals interactions were the vital forces involved in the binding process. CD, synchronous, and 3D fluorescence spectroscopic results revealed that GDC-0941 induced the structural change in HSA. Moreover, the conformational change of HSA affected its molecular sizes, as evidenced by AFM. This work provides a useful research strategy for exploring the interaction of GDC-0941 with HSA, thus helping in the understanding of the transport and delivery of dual inhibitors in the blood circulation system.

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LoRusso, Patricia, Geoffrey Shapiro, Shuchi Sumant Pandya, Eunice Lee Kwak, Cheryl Jones, Marcia Belvin, Luna C. Musib, et al. "A first-in-human phase Ib study to evaluate the MEK inhibitor GDC-0973, combined with the pan-PI3K inhibitor GDC-0941, in patients with advanced solid tumors." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 2566. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.2566.

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2566 Background: Both RAS/RAF/MEK and PI3K/Akt signaling pathways are deregulated in many tumor types. Targeting both pathways may be more efficacious than targeting either pathway alone. In preclinical models, concurrent administration of GDC‑0973, a potent, selective, MEK1/2 inhibitor and GDC-0941, a potent class I PI3K inhibitor, shows improved efficacy compared to either agent alone dosed continuously or intermittently. Methods: A phase Ib dose-escalation study with 3+3 design was initiated in patients (pts) with advanced solid tumors to evaluate the safety and pharmacokinetics (PK) of oral dosing of GDC-0973 and GDC-0941. Pts received: concurrent GDC-0973 + GDC-0941 once daily (qd) on a 21 day on/7 day off (21/7) schedule; intermittent GDC-0973 on Days 1, 4, 8, 11, 15, 18 of a 28 day cycle + GDC-0941 qd on a 21/7 schedule (MEK int); or GDC-0973 + GDC-0941 qd on a 7 day on /7 day off schedule (7/7). Starting doses were 20 mg GDC-0973 + 80 mg GDC-0941 (21/7), 100 mg GDC-0973 + 130 mg GDC-0941 (MEK int); 40 mg GDC-0973 + 130 mg GDC-0941 (7/7). Serial plasma PK samples, FDG-PET, and CT scans were obtained. Results: 78 pts have enrolled. DLTs were G3 lipase (n=1), G4 CPK elevation (n=1). Compared to the 21/7 MTD of 40 mg GDC-0973 + 100 mg GDC-0941, higher doses of GDC-0973 + GDC-0941 were tolerated on the MEK int schedule. Overall, adverse events related to the study drug combination in ≥ 20% pts were diarrhea, rash, nausea, fatigue, vomiting, decreased appetite, dysgeusia, and elevated CPK. Preliminary analysis indicated PK of GDC-0973 and GDC-0941 are not altered when dosed in combination. Of 46 evaluable pts, 26 had an FDG-PET partial metabolic response (≥ 20% decrease in mean SUVmax from baseline) at ≥1 time points. Partial responses were observed in 3 pts (mBRAF melanoma, mBRAF pancreatic ca, mKRAS endometrioid ca); 5 pts had stable disease ≥ 5 months. Conclusions: Combination dosing of GDC‑0973 and GDC-0941 is generally well tolerated, with toxicities similar to those observed in single agent GDC-0973 and GDC-0941 phase 1 trials. There are early signs of anti-tumor activity. Dose escalation on MEK int and 7/7 schedules continues and updated data will be presented.

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Ma, Xiaoju Max, Changchun Du, Laura Sun, Xiaoyan Shi, Lori Friedman, David Dornan, and Allen J. Ebens. "PI3K Signaling Pathway Activation Predicts Class I PI3K Inhibitor GDC-0941 Sensitivity in AML." Blood 114, no. 22 (November 20, 2009): 1057. http://dx.doi.org/10.1182/blood.v114.22.1057.1057.

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Abstract Abstract 1057 Poster Board I-79 The PI3K-Akt signal transduction pathway plays a key role in the pathogenesis of many human cancers. In AML malignancy, deregulation of upstream receptor tyrosine kinases such as FLT3, c-Kit, and c-FMS or mutations in K-Ras, N-Ras, B-Raf and CEBPA genes lead to activation of PI3K-Akt signaling to promote cell survival and cell growth. A highly selective Class I PI3K inhibitor, GDC-0941, provides exciting therapeutic opportunities for targeting this pathway in AML. Here we show that GDC-0941 significantly inhibits the viability of the majority of a large panel of AML cell lines tested in vitro (80% or 19/24) at a concentration of < 1 uM. Because not all AML cell lines responded to GDC-0941, we show that PI3K-Akt pathway activation, evidenced by basal pAkt level, can serve as a potential predictive biomarker for GDC-0941 in AML in that sensitive cell lines displayed higher level of pAkt relative to resistant cell lines. Consistently, GDC-0941 treatment leads to decreased pAkt, and therefore the down-regulation of this important pro-survival signaling. Our further analysis shows that GDC-0941 treatment can induce apoptosis and/or cell cycle arrest. We also obtained fresh AML tumor samples to test whether GDC-0941 can similarly induces apoptosis in blast cells and showed that GDC-0941 treatment results in a down-regulation of pAkt level and increased apoptosis. Other PD biomarkers such as phospho-BAD level and Bim expression are both consistent with the observed apoptotic responses. Furthermore, the mammalian target of rapamycin complex 1 (mTORC1) inhibitor, rapamycin, synergizes with GDC-0941 to produce an increased amount of apoptosis in several AML cell lines tested. This is likely due to the fact that long-term treatment with rapamycin induces the sensitivity of the PI3K –Akt signaling pathway by releasing the negative feedback loop of mTORC1-S6K-IRS1/2 module. Importantly, in some AML cell lines we observe synergies between GDC-0941 and AraC. Interestingly, while AraC alone does not induce apoptosis in AML cell lines with PTEN loss or mutation, the synergy between AraC and GDC-0941 comes from increased apoptotic response, suggesting that GDC-0941 can synergize with chemo agents that induces S/G2 cell cycle arrest. Together, our preclinical data suggest that GDC-0941 may be used as a targeted therapy in AML patients as a single agent or in combination with other chemotherapies in clinic. Disclosures: Ma: Genentech Inc.: Employment. Du:Genentech, Inc.: Employment, Equity Ownership. Sun:Genentech Inc.: Employment. Shi:Genentech, Inc.: Employment, Equity Ownership. Friedman:Genentech Inc.: Employment. Dornan:Genentech, Inc.: Employment, Equity Ownership. Ebens:Genentech, Inc.: Employment, Equity Ownership, Patents & Royalties.

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De, Pradip, Yuliang Sun, Lori Friedman, Nandini Dey, and Brian Leyland-Jones. "Effect of pan-PI3K and HER2 blockade on antitumor activity in preclinical models of breast cancer resistance to trastuzumab therapy." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): e13570-e13570. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e13570.

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e13570 Background: PI3K-AKT-mTOR pathway signaling is important for the oncogenic function of HER2. Activating alterations of this pathway are frequently observed in HER2-enriched breast cancer and generally herald a poor response and resistance to trastuzumab (T). Targeting the PI3K-AKT-mTOR pathway is an attractive strategy in HER2+ breast cancer that is refractory to trastuzumab. The hypothesis is that the suppression of this pathway by pan-PI3K inhibitor, GDC-0941 may lead to overcome trastuzumab-resistance. Methods: The antiproliferative and HER2-mediated cellular signaling (pAKT, pP70S6K, pS6RP, p4EBP1 and p-ERK) effects of GDC-0941 alone and in combination with T were evaluated in HER2 amplified T-sensitive (BT474), T-resistant (BT474HR), and HER2 amplified/PIK3CA mutated (HCC1954, UACC893) BT cell lines by MTT assay and Western blots. Athymic mice bearing BT474 and BT474HR xenograft tumors were treated with GDC-0941 and T (alone and in combination). Results: (1) GDC-0941 exhibited in vitro cell killing activity in MTT assay with IC50’s ranging from 0.35 µM to 1 µm and potency was augmented by the addition of T, (2) inhibition of phosphorylation of AKT(S473, T308), P70S6K, S6RP, and 4EBP1(T37/46, T70) was observed following GDC-0941 treatment, and the combination of GDC-0941 and T more effectively blocked the PI3K-AKT-mTOR pathway, (4) GDC-0941 dose-dependently blocked 3D-ON-TOP clonogenic growth of HER2+ cells. This effect was potentiated in the presence of T and (5) xenograft data show that the combination of GDC-0941 and T has strongly enhanced anti-tumor effect in both sensitive (82%) and resistant models (79%), something that cannot be achieved by either monotherapy. Conclusions: Our data suggest that 1) therapeutic targeting of the PI3K-AKT-mTOR signaling should be effective in abrogating resistance to T therapy in HER2+ BT, and 2) targeting both the HER2 and the PI3K signaling pathways is an attractive strategy to enhance the clinical activity of T therapy, as well as to prevent or delay the development of resistance.

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Jin, Linhua, Yoko Tabe, Yixin Zhou, Takashi Miida, Michael Andreeff, and Marina Konopleva. "Efficacy and Mechanisms of Apoptosis Induction by Simultaneous Inhibition of PI3K with GDC-0941 and Blockade of Bcl-2 (ABT-737) or FLT3 (Sorafenib) In AML Cells In the Hypoxic Bone Marrow Microenvironment." Blood 116, no. 21 (November 19, 2010): 777. http://dx.doi.org/10.1182/blood.v116.21.777.777.

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Abstract Abstract 777 Hypoxia and the interactions with bone marrow (BM) stromal cells have emerged as important mechanisms of leukemia cell survival and chemoresistance. The PI3K-Akt-mTOR-HIF1a signaling pathway has been shown to be activated in response to hypoxia in several cancer models including AML. Therefore, effective targeting of PI3K/Akt signaling pathway could suppress AML cell survival in the hypoxic BM microenvironment. Furthermore, concomitant intra-pathway blockade, or inhibition of the key pro-survival pathways may be more effective. In this study, we investigated the anti-leukemia effects and molecular mechanisms of apoptosis induction in the context of hypoxic bone marrow microenvironment by simultaneous use of a selective Class I PI3K inhibitor GDC-0941 (Genentech) with BH3 mimetic ABT-737 (Abbott) or FLT3 inhibitor sorafenib in AML cells. For hypoxia experiments, AML cells with FLT3-ITD mutation and wild-type FLT3 (FLT3-ITD: MOLM13, MV4;11, wt-FLT3: HL60) were cultured under 1.0% O2 for at least 14 days to assure their continuous proliferation and survival. Under hypoxia, more cells accumulated in G0/G1 phase, indicating that hypoxic conditions promote cell cycle quiescence in leukemic cells. GDC-0941 treatment in normoxia resulted in a reduction of cell proliferation with G0/G1 cell cycle arrest and minimal apoptosis induction, in a time and concentration-dependent manner (IC50 at 48 hrs; 0.7 μM for HL-60, 0.9 μM for MOLM13, 0.7 μM for MV4;11). In hypoxia, GDC-0941 further enhanced cell growth inhibition and G0/G1 cell cycle arrest. Importantly, co-culture with BM mesenchymal stroma cells (MSC), which protected AML cells from cytarabine induced apoptosis, did not affect cell growth inhibition by GDC-0941 both in normoxia and hypoxia. Combined treatment of GDC-0941 synergistically enhanced the ABT-737- or sorafenib induced apoptosis under both normoxic- and hypoxic conditions (p<0.05). Combination Index of GDC-0941/ABT-737 was 0.25 for HL-60 and 0.86 for MOLM13 cells; GDC-0941/sorafenib 0.58 for MV4;11 and 0.65 for MOLM13. In FLT3/ITD harboring MOLM13 and MV4;11 cells, ABT-737 and GDC-0941/ABT-737, or sorafenib and GDC-0941/sorafenib-induced apoptosis was partially reversed by MSC co-culture in normoxia, but not in hypoxia. We next examined the molecular mechanisms of apoptosis induction by simultaneous blockade of PI3K and mutant FLT3 in MOLM13 cells. GDC-0941 inhibited phospho-AktSer473, irrespective of oxygen tension. Hypoxia increased/induced phosphorylation of AktSer473, and of the pro-survival serine/threonine-protein kinase Pim-1, known to promote hypoxia-induced chemoresistance. Pim-1 is a downstream target of Akt and FLT-3 signaling that promotes cell survival and inhibits apoptosis through Bcl-2-dependent mechanisms. While GDC-0941 or ABT-737 alone did not affect hypoxia-induced Pim-1 levels, the GDC-0941/ABT-737 combination down-regulated Pim-1 by 86% (24 hrs). Treatment with sorafenib induced Pim-1 down-regulation by itself by 70%. Under hypoxia, expression levels of Bcl-2 family proteins Bcl-2 and BIM were not significantly changed by any treatment and cell culture conditions. In turn, Mcl-1 expression was upregulated by MSC co-cultures. Further, sorafenib alone but not GDC-0941 or ABT-737 decreased Mcl-1 protein levels, which was reversed by MSC co-culture in hypoxia; in turn, the GDC-0941/sorafenib or GDC-0941/ABT-737 combination potently suppressed Mcl-1 expression under MSC/hypoxia conditions. These changes were associated with the observed apoptotic responses. In summary, our findings indicate that hypoxic conditions of BM microenvironment result in stimulation of the pro-survival Akt and PIM kinase pathways and increase anti-apoptotic Mcl-1 protein in AML cells with mutated FLT3. In turn, simultaneous blockade of PI3K and FLT3 pathways, or of PI3K and Bcl-2 results in inhibition of these signaling modules and synergistic induction of apoptosis in AML. This data suggest that combined inhibition of Bcl-2 with PI3K or FLT3-ITD may constitute a targeted approach to eradicate chemoresistant AML cells sequestered in the hypoxic BM niches. Disclosures: No relevant conflicts of interest to declare.

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Sarker, D., R. Kristeleit, K. E. Mazina, J. A. Ware, Y. Yan, M. Dresser, M. K. Derynck, and J. De-Bono. "A phase I study evaluating the pharmacokinetics (PK) and pharmacodynamics (PD) of the oral pan-phosphoinositide-3 kinase (PI3K) inhibitor GDC-0941." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): 3538. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.3538.

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3538 Background: The PI3K-PTEN-AKT signaling pathway is deregulated in a wide variety of cancers. GDC-0941 is a potent and selective oral inhibitor of class I PI3K and demonstrates activity in a broad range of preclinical models (breast, ovarian, lung, and prostate). Methods: Patients (pts) with histologically confirmed advanced solid tumors and ECOG PS 0–1 were treated with GDC-0941 using a 3+3 escalation design at a single institution. Treatment was a single dose with 1wk washout, followed by GDC-0941 qd on a 3wk on, 1wk off schedule. Objectives were to determine MTD and DLT, evaluate PD endpoints in surrogate (pAKT in platelet rich plasma) and tumor (pAKT and pS6 in paired tumor biopsies and FDG uptake via PET imaging) tissues, and describe anti-tumor activity. Results: Thirteen patients have been enrolled in 4 successive cohorts (15–60 mg qd). GDC-0941 was generally well-tolerated with no drug related Grade 3 or 4 AEs or DLTs to date. Grade 1 diarrhea, nausea, dysgeusia, peripheral sensory neuropathy, dry mouth, thrombocytopenia, and increased aspartate aminotransferase have been observed. Preliminary PK data suggest dose-proportional increases in fasting mean Cmax and AUC. Preliminary PD data show decreased levels of pAKT in platelet rich plasma correlated with GDC-0941 plasma concentrations. GDC-0941 effects on FDG-PET imaging is being assessed, with 1 patient with HER2+ metastatic breast cancer showing a reduction in FDG uptake and improvement of a chest wall lesion (dose level 60 mg qd). Evaluation of PI3K pathway modulation from paired tumor biopsies is underway. Conclusions: GDC-0941 is generally well tolerated when administered qd at doses associated with inhibition of pAKT in surrogate tissues. Evidence of PD activity in tumor tissue has also been observed. Dose-escalation continues and updated PK/PD data will be presented. [Table: see text]

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Kikuchi, Hugh, Eunice Amofa, Maeve Mcenery, Steve Arthur Schey, Karthik Ramasamy, Farzin Farzaneh, and Yolanda Calle. "Inhibition of PI3K Class IA Kinases Using GDC-0941 Overcomes Cytoprotection of Multiple Myeloma Cells in the Osteoclastic Bone Marrow Microenvironment Enhancing the Efficacy of Current Clinical Therapeutics." Cancers 15, no. 2 (January 11, 2023): 462. http://dx.doi.org/10.3390/cancers15020462.

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Osteoclasts contribute to bone marrow (BM)-mediated drug resistance in multiple myeloma (MM) by providing cytoprotective cues. Additionally, 80% of patients develop osteolytic lesions, which is a major cause of morbidity in MM. Although targeting osteoclast function is critical to improve MM therapies, pre-clinical studies rarely consider overcoming osteoclast-mediated cytoprotection within the selection criteria of drug candidates. We have performed a drug screening and identified PI3K as a key regulator of a signalling node associated with resistance to dexamethasone lenalidomide, pomalidomide, and bortezomib mediated by osteoclasts and BM fibroblastic stromal cells, which was blocked by the pan-PI3K Class IA inhibitor GDC-0941. Additionally, GDC-0941 repressed the maturation of osteoclasts derived from MM patients and disrupted the organisation of the F-actin cytoskeleton in sealing zones required for bone degradation, correlating with decreased bone resorption by osteoclasts. In vivo, GDC-0941 improved the efficacy of dexamethasone against MM in the syngeneic GFP-5T33/C57-Rawji mouse model. Taken together, our results indicate that GDC-0941 in combination with currently used therapeutic agents could effectively kill MM cells in the presence of the cytoprotective BM microenvironment while inhibiting bone resorption by osteoclasts. These data support investigating GDC-0941 in combination with currently used therapeutic drugs for MM patients with active bone disease.

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Dail, Monique, Jason Wong, Jessica Lawrence, Daniel O'Connor, Joy Nakitandwe, Shann-Ching Chen, Keiko Akagi, et al. "Preclinical Testing Of a PI3K Inhibitor In T Lineage Leukemia: Target Validation and Notch1/Myc Down-Regulation In Drug Resistant Clones." Blood 122, no. 21 (November 15, 2013): 2677. http://dx.doi.org/10.1182/blood.v122.21.2677.2677.

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Abstract Mutations that deregulate Notch1 and Ras/PI3K/Akt signaling are common in T-ALL and often coexist. Thus, inhibiting these pathways alone and in combination has been advocated as a rational therapeutic strategy. GDC-0941 is a pan-PI3K inhibitor that is advancing in clinical development that we evaluated for efficacy and mechanisms of drug resistance in T-ALL cell lines and primary murine T-ALLs. Cell lines are uniformly sensitive to GDC-0941; however gradual dose escalation results in resistant lines. By contrast, primary leukemia cells display variable in vivo sensitivity to treatment with GDC-0941 +/- a MEK inhibitor. Importantly, mice invariably relapse with drug resistant clones. A majority of GDC-0941-resistant T-ALL cell lines and primary leukemias unexpectedly showed reduced levels of activated Notch1 protein, down-regulate many Notch1 target genes including Myc, and display cross-resistance to gamma secretase inhibitors (GSIs). In multiple cases, Notch1 mutations that were present in drug-sensitive parental leukemias were absent at relapse. Importantly, resistant clones that emerge both in vitro and in vivo up-regulate PI3K signaling indicating an “on pathway” mechanism of resistance. Consistent with these data, inhibition of Notch1 signaling promotes GDC-0941 resistance and enhances PI3K signaling, whereas expression of activated Notch1 increases the GDC-0941 sensitivity of mouse and human T-ALL cell lines. Thus, oncogenic Notch1 mutations that promote clonal outgrowth during malignant transformation unexpectedly undergo negative selection during treatment with GDC-0941. Together, these in vivo studies: (1) validate PI3K as an important therapeutic target in T-ALL; (2) demonstrate that active Notch1 and elevated Myc expression are dispensable for T-ALL growth in vivo; and, (3) indicate that therapeutic PI3K inhibition selects for the outgrowth of leukemia cells with reduced Notch1 signaling. Importantly, our data also raise the possibility that simultaneously administering Notch1 and PI3K inhibitors will accelerate drug resistance in T-ALL, and support alternative approaches for deploying combination regimens against these dominant oncogenic “driver” pathways. Disclosures: Lee: Genentech: Employment. Aster:Cell Signaling Technology: Consultancy; Merck, Inc.: Research Funding; Pfizer, Inc.: Research Funding; Genentech, Inc.: Honoraria. Sampath:Genentech: Employment, Equity Ownership.

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Dissertations / Theses on the topic "0941"

Rusconi, Roberto. "Integrated musical perspectives : how matter becomes art music : portfolio of compositions and technical commentary." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/integrated-musical-perspectives(e7f19391-0941-4428-bc06-217f8c998f45).html.

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This thesis accompanies the folio of the acoustic and electroacoustic compositions of the portfolio, which consists of a work for soli, choirs and orchestra, an orchestral piece, a solo for oboe, four ensemble chamber composition and a string quartet with sound projection and live electronics. The works exhibit a variety of cross-disciplinary approaches from theatrical, live electronics, networked performance, and narrative and multichannel/sound projection. The main concerns spanning the portfolio are the connections navigated through a 'synthesis' of multiple disciplines within the language of acoustic and electroacoustic music, and challenging areas of research that question and raise new musical possibilities. In all these works the morphological handling of music matter is always intertwined with issues of formal construction. For each composition I described applied studio techniques, sound sources, transformations and formal elements. As compositional tools, special software have been used, explored and developed in contrasting programming languages. These programs are briefly introduced, showing their links to compositional processes. The commentary presents supplementary information on each work, with a view to providing the reader with insights into the evolution of my compositional vocabulary. A particular attention has been devoted to the pre compositional and perceptual spatial aspects of my work, with reference to theoretical writings and research in the field.

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Patel, Shanon. "The clinical applications of cone beam computed tomography in endodontics." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/the-clinical-applications-of-cone-beam-computed-tomography-in-endodontics(28daff53-0941-4b36-b8ea-beeb7dc2a8e6).html.

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A series of 5 investigations assessed the application of cone beam computed tomography (CBCT) for the management of endodontic problems. Cone beam computed tomography improved the detection of the presence and absence of simulated periapical lesions in human dry mandibles. The overall sensitivity was 0.248 and 1.0 for periapical radiography and CBCT respectively. The receiver operating characteristics (ROC) area under the curve (AUC) values were 0.791 and 1.000 for intraoral radiography and CBCT, respectively. There was no improvement in the detection of artificially created vertical root fractures (VRF) in root treated teeth using CBCT compared with periapical radiographs. The overall AUC value of incomplete and complete VRF was 0.53 for periapical radiography and 0.45 for CBCT (p=0.034). The overall sensitivity of periapical radiography (0.05) was lower than CBCT (0.57) regardless of the extent of the VRF (p=0.027). Periapical radiographs (0.98) had a higher overall specificity than CBCT (0.34), (p=0.027). The prevalence of periapical radiolucencies of 273 individual roots in 151 teeth viewed with CBCT (48%) of teeth treatment planned for endodontic treatment was significantly higher when compared with periapical radiographs (20%). Periapical radiographs and CBCT scans of 123 of the teeth in 99 patients assessed 1 year after completion of primary root canal treatment were compared to their respective pre-treatment periapical radiographs and CBCT scans. Analysis by tooth revealed that the ’healed’ rate (absence of periapical radiolucency) was 87% using periapical radiographs and 62.5% using CBCT (p<0.001). This increased to 95.1% and 84.7% respectively when the ’healing’group (reduced size of periapical radioiUcency) was included (p<0.002). Outcome diagnosis of teeth showed a statistically significant difference between systems (p<0.001). The influence of periapical radiography and CBCT for the detection and management of in-vivo root resorption lesions was assessed. Periapical radiography ROC ADC values were 0.780 and 0.830 for diagnostic accuracy of internal and external cervical resorption respectively. The CBCT ROC AUC values were 1.000 for both internal and external cervical resorption. There was a significantly higher prevalence (p=0.028) for the correct treatment option being chosen with CBCT compared with intraoral radiographs. These investigations demonstrated that CBCT is more effective in diagnosis ex vivo and in vivo periapical radiolucencies, and for the diagnosis and management of root resorption. However, CBCT did not improve the detection of VRF in this experimental model.

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Geng, Xinyan. "Investigations into how best to target FGFR2 mutant endometrial cancer." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/123437/1/Xinyan%20Geng%20Thesis.pdf.

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Endometrial cancer (EC) is the fourth most common cancer in women in developed countries, such as North America, Europe and Australia. Patients with low-grade, early-stage disease usually have a favourable survival rate. However, patients that present at an advanced stage of disease have an average survival of only 12 months. Current treatments for these patients are radiation and chemotherapy, which offer limited clinical benefit. There is no efficient treatment for advanced EC. Improved therapeutic approaches are needed for the treatment of recurrent and metastatic endometrial cancer. Recent advances in cancer biology have resulted in the development of molecular targeted therapies. The Fibroblast Growth Factors Receptor (FGFR) family and their ligands (fibroblast growth factors, FGFs) regulate a broad spectrum of physiological processes as well as tissue patterning and organogenesis during embryogenesis. Abnormally activated FGFRs have been identified in various cancers and are emerging as potential therapeutic targets. The Pollock laboratory and other groups have demonstrated that 10-20% of endometrioid ECs carry FGFR2 mutations that may be a novel therapeutic target in endometrial carcinoma. Preclinical studies show that inhibition of FGFR can inhibit EC cell growth in vitro. However, FGFR inhibitors are not as efficient at inhibiting tumour growth in vivo. We aim to find a way to improve the efficacy of FGFR inhibition in cancer treatment. About 90% of EC patients harbour genetic aberrations in the components of the PI3K/AKT pathway which indicates this signalling pathway plays an important role in the development of EC. Work from our lab demonstrates that inhibition of FGFR results in abrogation of MAPK activation in sensitive EC cells, however, the PI3K/AKT signalling pathway remains unaffected. PI3K/AKT signalling plays a vital role in cancer cell proliferation and survival, furthermore crosstalk between the MAPK and PI3K/AKT signalling pathways is associated with resistance to targeted therapies. Thus, the first aim of this study was to examine whether combination of the FGFR inhibitor (BGJ398) with various different PI3K inhibitors was synergistic in FGFRi sensitive EC cells. We present data that the combination of the pan-FGFR inhibitor (BGJ398) with pan-PI3K inhibitors (GDC-0941, BKM120) or a p110α-selective PI3K inhibitor (BYL719) was synergistic in inhibiting cell growth. Significantly more cell death and inhibition of long-term cell survival was observed in the combination treatments compared to each of the single drug treatments. Importantly, these effects could also be observed at lower concentrations. This study is the first to indicate that partial inhibition of the PI3K signalling pathway could significantly increase cell death when combined with the FGFR inhibitor BGJ398 in FGFR2 mutant EC cells. These data provide evidence that sub-therapeutic doses of PI3K inhibitors could enhance the efficacy of anti-FGFR therapies and a combination therapy may represent a superior therapeutic treatment in FGFR2 mutant EC patients. The in vivo work (conducted by Dr Vanessa Bonazzi) shows that the combination of BGJ398 and GDC-0941 and BYL719 resulted in tumour regression, while single drug treatment only slowed tumour growth. Interestingly, BYL719 alone resulted in increased tumour growth in tumour xenografts of AN3CA but not JHUEM2. In the first results chapter we further investigated the mechanism of enhanced cell death from the combination of BGJ398 and PI3K inhibitors. The activation of ERK and AKT has been inhibited by the combination of BGJ398 and PI3K inhibitors. However, the combination of the MEK inhibitor trametinib and the PI3K inhibitors induced less cell death than inhibition of the FGFR and PI3K signalling pathways. BGJ398 but not trametinib or GDC-0941 inhibited the activity of PLCγ1. We have also found trametinib up-regulated PLCγ1 activity, which is a novel finding in the field. We next employed several pharmacological inhibitors to investigate whether PLCγ1 is involved in the cell death observed following the combination of BGJ398 and GDC-0941 treatment. As there is no PLCγ1 inhibitor available currently, we used two different pan-PLC inhibitors, manoalide and U73122. Co-inhibition of the MAPK, PI3K/AKT and PLC signalling recapitulated cell growth inhibition seen with the combination of FGFR and PI3K inhibitor in both cell lines. Cell death induced by the combination of PLC inhibitors with trametinib and GDC0941 was similar as the combination BGJ398 and GDC0941 in AN3CA, but significantly less than the combination BGJ398 and GDC0941 in JHUEM2. Unfortunately, Western blotting was unable to show inhibition of PLCγ1 bringing into question whether these PLC inhibitors inhibited PLC function sufficiently, and whether the phenotypic effects of manoalide and U73122 when added to the trametinib and GDC0941 combination are due to inhibition of PLCγ1. The second results chapter reports efforts to identify the mechanism of intrinsic resistance to FGFR inhibition in EC cell lines carrying FGFR2 activating mutations but showing intrinsic resistance to FGFR inhibition (EI, EN1078D, and MFE319) with comparisons to the two sensitive EC cell lines (JHUEM2 and AN3CA). We have observed sustained activation of ERK in the resistant cells after treatment with an FGFR inhibitor, while ERK was inhibited in the sensitive cells. Inhibition of the MAPK signalling pathway could not sensitise the resistant cells to FGFR inhibition. Although several other receptor tyrosine kinases (RTKs) were hyperactivated in these cells, pharmacological inhibition did not show they were reliant on these RTKs. Co-inhibition of these kinases did not sensitise these cells to BGJ398. Knockdown of FGFR2 by shRNA in the sensitive cells induced moderate cell death, but limited cell death in the resistant cells. Interestingly, co-inhibition of the MAPK, PI3K/AKT and PLC signalling pathways has induced markedly less cell growth inhibition in the resistant cells compared to the sensitive cells, suggesting the resistant cells are less dependent on these central signalling pathways than the sensitive cells. Western blotting results showed that FGFR2 expression was considerably lower in the resistant cells than in the sensitive cells. Based on these results we have concluded that FGFR2 mutation status is not the only factor that determines sensitivity to FGFR inhibition, high expression of mutant FGFR2 is also important. This is a novel finding in the field and one which could guide patient select criteria in future clinical trials. Lastly, we show that FGFR2 knockdown in medium containing 10% FBS has little impact on downstream ERK phosphorylation whereas pan FGFR inhibition with BGJ398 could totally abrogate ERK phosphorylation. In cells grown overnight in serum starved conditions, FGFR2 knockdown did reduce downstream ERK phosphorylation but not to the same extent as pan FGFR inhibition in full growth medium. These data suggest that inhibition of FGFR2 alone is insufficient and that inhibition of multiple FGFRs will be more effective as a cancer treatment.

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Sava, Olga. "Dualismus der Einkunftsarten Ansätze zur Steuerreformdiskussion aus betriebswirtschaftlicher Sicht /." Wiesbaden : Deutscher Universitäts-Verlag, 2007. http://sfx.metabib.ch:9003/sfx_locater?sid=ALEPH:DSV01&genre=book&isbn=978-3-8350-0941-7&id=doi:10.1007/978-3-8350-5489-9.

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Lakshmanan, Aparna. "Modulation of Sodium Iodide Symporter-mediated Thyroidal Radioiodide Uptake by Small Molecule Inhibitors, Natural Plant-based Products and microRNAs." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429407914.

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Diab, Duranton Salam. "Phonétique et sémantique dans le lexique de l'arabe : le "'Ibdal" dans la tradition grammaticale arabe, l'étude de la matrice {[coronal], [dorsal]}." Lyon, Ecole normale supérieure, 2009. http://www.theses.fr/2009ENSF0061.

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The thesis comprises two main parts : one historical and the other theoretical. The first part is a study of the ’ibdāl in which several salient works are analysed. Four Arab scholars whose works are the most important in the area under consideration are studied : Ibn al-Sikkīt, Al-Zajjājī, Abū al-Ṭayyib al-Luġawī and Ibn Jinnī. We examine the way in which, within the framework of the Arabic grammatical tradition, the lexicographers and grammarians have apprehended the phonetic and semantic similarities present in the Arabic lexicon and which are referred to by the name : ’ibdāl. The second part is a contribution to the theory of matrices and etymons (TME) elaborated by G. Bohas. We apply TME to the study of the {[coronal], [dorsal]} matrix which has a substantial lexical corpus. We endeavour to demonstrate that meaning is organized around a matrix of features (a macro-significant) associated with a macro-signifié. We also examine the polysemic, homonymic or enantiosemic relationships which are present within the same lexical heading, establishing the typology of these semantic combinations arising from the crossing of etymons
La thèse s’articule en deux grandes parties : une historique et l’autre théorique. La première propose une étude du ’ibdāl par l’analyse de quelques ouvrages repères. Quatre savants arabes y sont étudiés : Ibn al-Sikkīt, Al-Zajjājī, Abū al-Ṭayyib al-Luġawī et Ibn Jinnī dont les œuvres sont les plus importantes dans le domaine concerné. Nous y examinons la manière dont les lexicographes et grammairiens ont, dans le cadre de la tradition grammaticale arabe, appréhendé les similitudes phonétiques et sémantiques présentes dans le lexique de l’arabe et désignées sous le nom de : ’ibdāl. La seconde partie se veut une contribution à la théorie des matrices et étymons (TME) élaborée par Bohas. Notre contribution consiste dans l’étude de la matrice {[coronal], [dorsal]} qui présente un corpus lexical conséquent. Nous nous attachons à montrer que le sens s’articule en une matrice de traits (macro-signifiant) associée à un macro-signifié. Nous étudions également les relations de polysémie, d’homonymie ou d’énantiosémie présentes au sein d’une même entrée lexicale, en établissant la typologie de ces combinaisons sémantiques issues du croisement des étymons

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Bell, Samuel D. "The impact of the Type 094 ballistic missile submarine on China's nuclear policy." Thesis, Monterey, Calif. : Naval Postgraduate School, 2009. http://edocs.nps.edu/npspubs/scholarly/theses/2009/Jun/09Jun%5FBell.pdf.

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Thesis (M.A. in Security Studies (Far East, Southeast Asia, and the Pacific))--Naval Postgraduate School, June 2009.
Thesis Advisor(s): Twomey, Christopher. "June 2009." Description based on title screen as viewed on July 13, 2009. Author(s) subject terms: Type 094, Chinese Nuclear Policy, No First Use, Jin, Ballistic Missile Submarine Includes bibliographical references (p. 99-108). Also available in print.

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Stubbs, Estelle Vivien. "A study of the codicology of four early manuscripts of the Canterbury Tales." Thesis, University of Sheffield, 2006. http://etheses.whiterose.ac.uk/15177/.

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This thesis is a study of the physical features of the four earliest manuscripts of the Canterbury Tales all dated to the first years after the death of Geoffrey Chaucer. I assess the ways in which codicological examination can contribute to the understanding of a complex textual tradition and inform the study of the text. The thesis is divided into two volumes. The first volume contains the seven chapters which make up the thesis. The first chapter contains a review of the printed editions of the poem since Caxton's first edition of 1476 and a summary of the most important contributions of scholarship in the twentieth century. It reveals that many influential editions and much scholarship on the textual tradition of the poem have been achieved with scant consultation of the extant manuscripts. The second chapter addresses the problems which have arisen as a result of this neglect and offers suggestions for a different approach to manuscript analysis which will be provided as a result of the examination of the manuscripts in the remainder of the thesis. Chapters three to six contain detailed analyses of the four manuscripts in the survey: Aberystwyth, National Library of Wales MS. Peniarth 392D (Hengwrt), Oxford, Corpus Christi College, MS. 198 (Corpus), London, British Library MS. Harley 7334 (Harley 4), and California, San Marino, Huntington Library MS. El. 26 C 9 (Ellesmere). In chapter seven, I summarise the findings and offer suggestions for future research. The second volume contains all the appendices numbered 1-20 followed by 22 Plates. For each manuscript there are four or five separate appendices which provide details of the following: a visual overview, a detailed analysis of individual quires, a list of all rubrics, lines added, omitted or variant in each manuscript, and a list of catchwords.

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Himsworth, Katherine. "The Peniarth MS 22 Brut y Brenhinedd and continuation chronicle, and its 15th century Aberystwyth scribe, Dafydd ap Maredudd Glais." Thesis, Aberystwyth University, 2015. http://hdl.handle.net/2160/5dcc8e8b-3f1d-4a4d-9713-d9ed9c7288f1.

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The Peniarth 22 manuscript is, except for the last four pages, a fifteenth-century copy of Brut y Brenhinedd, the Welsh translation of Geoffrey of Monmouth's Historia Regum Britanniae; it was penned in 1444 by one Dafydd ap Maredudd Glais. It belongs to the Dingestow family of manuscripts, which in turn is related, in part, to the Llanstephan Version and Liber Coronacionis Britanorum manuscripts, although the detail of this relationship - and that of the Dingestow manuscripts to one another - still begs a number of questions. Peniarth 22 itself is very similar to, though not a copy of, the early fourteenth-century NLW 3036B manuscript. But there are differences in the orthography, and to a lesser extent in the grammatical constructions used by Dafydd which shed light on the changes that were being gradually adopted in the fifteenth century. This is particularly true of the last four pages, which contain Dafydd's own translation of a Latin chronicle, which comprises a continuation of the Brut. While incomplete, largely formulaic and in parts illegible, it includes detail of historical as well as linguistic interest. Dafydd himself, far from being an institutional scribe, led a colourful life including both murder and public service in fifteenth-century Aberystwyth. But he was not, as previously thought, a cleric.

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Wang, Jianlan. "Silk facing of ancient Chinese manuscripts." Thesis, Queen's University Belfast, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675481.

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The thesis has profiled silk facing treatments to manuscripts in the Stein Collection in the British Library, via its unique historical background, compared with the lamination technique that was prevalent in conservation in the last century in libraries and archives. The correction of the previous inappropriate preservation methods might have not aroused enough attentiveness, or critical attention, in the conservation arena. IR and Raman spectroscopy were widely applied in this project, for the characterisation of the different silks removed from the manuscripts, in comparison with new silk from commercial suppliers, revealing the ageing of silk, its fragility and stiffness, which causes mechanical abrasion toward the scrolls of ancient manuscripts. Silk's absorption of moisture, and exposure to light, exacerbate this problem. The characterisation of a series of vegetable and animal derived glues emphasises the poor record-keeping of the conservation studios. The non-native and pipeline-processed starches show almost the same pattern in both IR and Raman spectroscopy. Animal glues also show different patterns from the starch-based glues in both IR and Raman spectroscopy. The problems of applying gelatine-base glue in the conservation process are also discussed. The dye-transfer phenomenon has been confirmed: the yellow dye from the manuscripts (which were dyed by water-soluble huangbo extracts) transfer to the glue paste and then to the silk materials, thus causing the discolouration of the manuscripts. Finally, solid-state NMR characterisation with magic angle spinning was used to characterise the silks and glue pastes. The SEM and EDAX study provided the evidence for the existence of fungi and/or bacteria on the glues al1ached to the manuscripts, data being provided from a strong collaboration with Dr. Cristina Silva Pereira from the Universidade Nova de Lisboa, Portugal. Preliminary studies have confirmed that the silk and glue carry Aspergillus niger, Neurospora crass a and Penicillium chrysogenum. This observation provides unimpeachable evidence that long-term damage will occur to the faced manuscripts if the facing is not removed. Currently, the desire for digitisation of manuscripts in the Stein collection in the British Library also enhances the case for the removal of the silk facing materials. The sill<, glue, water and dye, compose a complicated matrix which influence the lifetime and stability of the manuscripts by interaction with the external environment, thus it is believed that the removal the silk facing materials is reasonable, and should be performed if economically viable

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Books on the topic "0941"

1948-, Allan Graham, and Crow Graham, eds. Home and family: Creating the domestic sphere. Houndmills, Basingstoke, Hampshire: Macmillan, 1989.

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Provder, Theodore, ed. Film Formation. Washington, DC: American Chemical Society, 2006. http://dx.doi.org/10.1021/bk-2006-0941.

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Frank, Leishman, Loveday Barry, and Savage Stephen P, eds. Core issues in policing. London: Longman, 1996.

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1948-, Matthews Roger, and Young Jock, eds. Issues in realist criminology. London: Sage Publications, 1992.

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1925-, Burnett John, ed. A social history of housing, 1815-1985. 2nd ed. London: Methuen, 1986.

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1915-, Hood Stuart Clink, ed. Behind the screens: The structure of British broadcasting in the 1990s. London: Lawrence & Wishart, 1994.

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Jane, Aaron, and Walby Sylvia, eds. Out of the margins: Women's studies in the nineties. London: Falmer Press, 1991.

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Finger, Stanley, T. E. Levere, C. Robert Almli, and Donald G. Stein, eds. Brain Injury and Recovery. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-0941-3.

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Gamatie, Abdoulaye. Designing Embedded Systems with the SIGNAL Programming Language. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-0941-1.

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Ansarian, Loghman, and Mei Lin Teoh. Problem-based Language Learning and Teaching. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-0941-0.

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Book chapters on the topic "0941"

Chihara, H., and N. Nakamura. "NQRS Data for C6H24Br6N3Sb (Subst. No. 0941)." In Landolt-Börnstein - Group III Condensed Matter, 1090. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-02892-2_946.

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Zhang, Yuemei, Justin Doo, David Krouse, and David Kranbuehl. "UV-Induced Film Formation Kinetics as a Function of Film Thickness and in the Adjacent Dark Non-Irradiated Region." In ACS Symposium Series, 3–16. Washington, DC: American Chemical Society, 2006. http://dx.doi.org/10.1021/bk-2006-0941.ch001.

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Lee, Tai Yeon, T. M. Roper, C. Allan Guymon, E. Sonny Jonsson, and Charles E. Hoyle. "Copolymerization Mechanism of Photoinitiator Free Thiol—Vinyl Acrylate Systems." In ACS Symposium Series, 17–28. Washington, DC: American Chemical Society, 2006. http://dx.doi.org/10.1021/bk-2006-0941.ch002.

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Roper, Todd M., C. Allan Guymon, and Charles E. Hoyle. "Photopolymerization Kinetics of Pigmented Systems Using a Thin-Film Calorimeter." In ACS Symposium Series, 29–40. Washington, DC: American Chemical Society, 2006. http://dx.doi.org/10.1021/bk-2006-0941.ch003.

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Belaroui, F., B. Cabane, Y. Grohens, P. Marie, and Y. Holl. "Desorption of Surfactants During Film Formation." In ACS Symposium Series, 41–51. Washington, DC: American Chemical Society, 2006. http://dx.doi.org/10.1021/bk-2006-0941.ch004.

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Gundabala, Venkata R., and Alexander F. Routh. "Predicting Surfactant Distributions in Dried Latex Films." In ACS Symposium Series, 53–65. Washington, DC: American Chemical Society, 2006. http://dx.doi.org/10.1021/bk-2006-0941.ch005.

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Ge, Haiyan, Cheng-Le Zhao, Shane Porzio, Li Zhuo, H. T. Davis, and L. E. Scriven. "Cryo-Scanning Electron Microscopy of Film Formation in Regular and Low-Volatile Organic Contents Waterborne Latex Coatings." In ACS Symposium Series, 69–90. Washington, DC: American Chemical Society, 2006. http://dx.doi.org/10.1021/bk-2006-0941.ch006.

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Zhang, Junjie, Hongmin Chen, Quang Liu, L. Chakka, and Y. C. Jean. "Characterization of Free-Volume Properties of Surface and Interfaces in Thin Film Using Positron Annihilation Spectroscopy." In ACS Symposium Series, 91–104. Washington, DC: American Chemical Society, 2006. http://dx.doi.org/10.1021/bk-2006-0941.ch007.

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Urban, Marek W. "Recent Advances in Film Formation from Colloidal Particles: Synthesis of Non-Spherical Colloidal Shapes with Stimuli-Responsive Characteristics." In ACS Symposium Series, 105–22. Washington, DC: American Chemical Society, 2006. http://dx.doi.org/10.1021/bk-2006-0941.ch008.

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Wang, Xiaorong, and Naruhiko Mashita. "Formation of Films of Two-Dimensional Continuous Network Skeleton." In ACS Symposium Series, 123–35. Washington, DC: American Chemical Society, 2006. http://dx.doi.org/10.1021/bk-2006-0941.ch009.

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Conference papers on the topic "0941"

Spoerke, Jill, Carol O'Brien, Zach Boyd, Sankar Mohan, Ajay Pandita, Leanne Berry, Jane Fridlyand, et al. "Abstract 4116: Predictive biomarkers for the PI3 kinase inhibitor GDC-0941 in NSCLC." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-4116.

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Trinh, Greenfield T., and Kenneth Cheung. "Modular Rapidly Manufactured Small Satellite (MRMSS)." In 53rd AIAA Aerospace Sciences Meeting. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2015. http://dx.doi.org/10.2514/6.2015-0941.

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Guimarães, Thiago A., Domingos Rade, Carlos E. Cesnik, and Flavio D. Marques. "Nonlinear Multibay Panel Flutter Evaluation of Composite Laminates with Curvilinear Fibers." In AIAA Scitech 2020 Forum. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2020. http://dx.doi.org/10.2514/6.2020-0941.

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Mejia, Nicholas, and Bryan E. Schmidt. "Experimental Investigation of Flow Interaction Dynamics in Supersonic Retropropulsion." In AIAA Scitech 2021 Forum. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2021. http://dx.doi.org/10.2514/6.2021-0941.

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Nikoueeyan, Pourya, and Jonathan W. Naughton. "Photogrammetry for Masking Particle Image Velocimetry Images Near Moving Bodies." In 55th AIAA Aerospace Sciences Meeting. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2017. http://dx.doi.org/10.2514/6.2017-0941.

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Munk, David J., Nicholas F. Giannelis, and Gareth A. Vio. "Experimental Validation of Structures Optimised for Frequency Constraints and Dynamic Loading." In 57th AIAA/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2016. http://dx.doi.org/10.2514/6.2016-0941.

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Washko, Frank M., and Ming-Chia Lai. "Fuel Economy Improvement Potential of a PFI Gasoline Engine Using VVT/VCR." In ASME 2004 Internal Combustion Engine Division Fall Technical Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/icef2004-0941.

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It is desired to optimize a spark ignition PFI (port fuel injected) engine for various regimes within the operating ranges of a vehicle. The goal of this work is to identify the set of technologies that complement each other and offer the optimum performance and fuel economy. For an ideal powertrain system, the engine should be optimized for best fuel economy during the typical drive cycles and best performance during high load acceleration. A typical PFI 1.8L four-cylinder engine is baselined at cycle representative speed/load points. The engine is supercharged and intercooled to later quantify the efficiency benefits from replacing a larger engine with a smaller boosted engine that offers similar performance. Then the effects of different operating regimes and the effect of different proposed technologies are studied. The fuel economy enablers considered include variable valve timing (VVT) and variable compression ratios (VCR). The effects of VVT was studied to see which valve event scenarios afford the best operating efficiency and fuel economy during part load operation. VVT can also be a source of performance improvement if implemented appropriately. VCR operation is studied to see if the efficiency gains from VCR are additive with VVT or if they overlap to some degree. Typically, the fuel efficiency potential of a production engine is limited by spark knock. The engine studied here uses the geometrical and virtual compression ratio reductions offered by the VVT and VCR systems to give knock limit relief and allows the knock-limited BMEP curve to be pushed up. The results showed that the fuel economy gain with the above mentioned technologies is somewhat additive throughout the typical driving cycle but is highly dependent on proper optimization of the many system variables.

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Helm, Clara M., M. Pino Martin, and Pierre Dupont. "Characterization of the Shear Layer in a Mach 3 Shock/Turbulent Boundary Layer Interaction." In 52nd Aerospace Sciences Meeting. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2014. http://dx.doi.org/10.2514/6.2014-0941.

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Murphey, Thomas W., and William F. Davidson. "High Strain Composite Folding Truss Structures." In 2018 AIAA Spacecraft Structures Conference. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2018. http://dx.doi.org/10.2514/6.2018-0941.

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Hudson, Keith, Andrew J. Lingenfelter, and Joshuah A. Hess. "Dynamic Mass Balancing of a Spacecraft Test Platform." In AIAA Scitech 2019 Forum. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2019. http://dx.doi.org/10.2514/6.2019-0941.

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Reports on the topic "0941"

Dyer, T. Michael, Charles Westbrook, Colin Grieves, Jim Seebold, John Pratapas, Doug J. Harrison, Walter Farmayan, Cherif Youssef, and Lee Gilmer. Toxic Combustion By-Products: Final Report CRADA No. TC-0947-94. Office of Scientific and Technical Information (OSTI), November 2000. http://dx.doi.org/10.2172/1410048.

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Westbrook, C. Toxic Combustion By-Products: Final Report CRADA No. TC-0947-94. Office of Scientific and Technical Information (OSTI), November 2000. http://dx.doi.org/10.2172/790114.

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Gruel, Robert L., Edward F. Love, and Cheryl K. Thornhill. UNCLASSIFIED TPBAR RELEASES, INCLUDING TRITIUM TTQP-1-091 Rev 14. Office of Scientific and Technical Information (OSTI), July 2012. http://dx.doi.org/10.2172/1089105.

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Narlesky, Joshua Edward, Paul Herrick Smith, Timothy Amos Stone, and Douglas Kirk Veirs. TA55 Nuclear Material Packaging, TA55-DOP-091 / PA-RD-01022. Office of Scientific and Technical Information (OSTI), March 2019. http://dx.doi.org/10.2172/1503176.

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Iliev, Metodi, and Kiril Dimitrov Ianakiev. Report on Task USA A 0931 (A.252) Implementation of Fast, Front-End Electronics for Improved Low-Dead Time Neutron Counting. Office of Scientific and Technical Information (OSTI), December 2019. http://dx.doi.org/10.2172/1581264.

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Manning, Wendy, and Lisa Carlson. Trends in Cohabitation Prior to Marriage (FP-21-04). National Center for Family and Marriage Research, February 2021. http://dx.doi.org/10.25035/ncfmr/fp-21-04.

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Disparities in unintended childbearing remain a public health concern (Healthy People 2030). Using the 2015-19 cycle of the National Survey of Family Growth, we examine sociodemographic variation in birth intendedness, looking at births occurring between 2014-2018 to women aged 15-49. Birth intendedness is based on a series of questions in which women are asked to characterize each birth as on time, mistimed (wanted but occurring earlier than desired), or unwanted (the respondent did not want any births at all, or any additional births). When births are reported as too early, women were then asked how much earlier than desired the birth occurred. We categorize mistimed births into two groups: slightly mistimed (less than two years earlier than desired) or seriously mistimed (two or more years too early). This profile is an update of FP-17-091 and the second in a series on unintended childbearing in the U.S.

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Data for DCP probe BAY-091. EMBL-EBI, March 2022. http://dx.doi.org/10.6019/chembl4800729.

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Health hazard evaluation report: HETA-93-0951-2382, Hodges and King, DDS, Atlanta, Georgia. U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, January 1994. http://dx.doi.org/10.26616/nioshheta9309512382.

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Source rock potential and geochemical characterization of OCS Y-0943-1 (Aurora #1) well as determined from unwashed cuttings (6,960-14,190'). Alaska Division of Geological & Geophysical Surveys, 1993. http://dx.doi.org/10.14509/19049.

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Health hazard evaluation report: HETA-83-091-1637, Residences (Times Beach Flood Debris Cleanup), Times Beach, Missouri. U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, November 1985. http://dx.doi.org/10.26616/nioshheta830911637.

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