Relevant bibliographies by topics / 030401 Biologically Active Molecules

Academic literature on the topic '030401 Biologically Active Molecules'

Author: Grafiati
Published: 10 December 2022
Last updated: 29 January 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Contents

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic '030401 Biologically Active Molecules.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "030401 Biologically Active Molecules"

1

Kovalson, V. M., A. O. Golovatyuk, and M. G. Poluektov. "Biologically active molecules and sleep." Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 122, no. 5 (2022): 6. http://dx.doi.org/10.17116/jnevro20221220526.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Hamilton, A. D., N. Pant, and A. Muehldorf. "Artificial receptors for biologically active molecules." Pure and Applied Chemistry 60, no. 4 (January 1, 1988): 533–38. http://dx.doi.org/10.1351/pac198860040533.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Karolak-Wojciechowska, J., and A. Fruzinski. "Spacer conformation in biologically active molecules." Pure and Applied Chemistry 76, no. 5 (January 1, 2004): 959–64. http://dx.doi.org/10.1351/pac200476050959.

Full text
Abstract:
Based on our contemporary studies on the structures of biologically active molecules, we focus our attention on the aliphatic chain and its conformation. That flexible spacer definitely influenced the balanced position of all pharmacophoric points in molecules of biological ligands. The one atomic linker and two or three atomic spacers with one heteroatom X =O, S, CH2, NH have been taken into account. The conformational preferences clearly depend on the heteroatom X. In the discussion, we utilize our own X-ray data, computation chemistry methods, population analysis, and statistical data from the Cambridge Structural Database (CSD).
APA, Harvard, Vancouver, ISO, and other styles
4

Weissig, Volkmar. "Mitochondrial Delivery of Biologically Active Molecules." Pharmaceutical Research 28, no. 11 (September 21, 2011): 2633–38. http://dx.doi.org/10.1007/s11095-011-0588-1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Kanai, Motomu, and Masakatsu Shibasaki. "Catalytic Asymmetric Synthesis of Biologically Active Molecules." Journal of Synthetic Organic Chemistry, Japan 65, no. 5 (2007): 439–49. http://dx.doi.org/10.5059/yukigoseikyokaishi.65.439.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Mayer, Günter, and Alexander Heckel. "Biologically Active Molecules with a “Light Switch”." Angewandte Chemie International Edition 45, no. 30 (July 24, 2006): 4900–4921. http://dx.doi.org/10.1002/anie.200600387.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Insuasty, Daniel, Juan Castillo, Diana Becerra, Hugo Rojas, and Rodrigo Abonia. "Synthesis of Biologically Active Molecules through Multicomponent Reactions." Molecules 25, no. 3 (January 24, 2020): 505. http://dx.doi.org/10.3390/molecules25030505.

Full text
Abstract:
Focusing on the literature progress since 2002, the present review explores the highly significant role that multicomponent reactions (MCRs) have played as a very important tool for expedite synthesis of a vast number of organic molecules, but also, highlights the fact that many of such molecules are biologically active or at least have been submitted to any biological screen. The selected papers covered in this review must meet two mandatory requirements: (1) the reported products should be obtained via a multicomponent reaction; (2) the reported products should be biologically actives or at least tested for any biological property. Given the diversity of synthetic approaches utilized in MCRs, the highly diverse nature of the biological activities evaluated for the synthesized compounds, and considering their huge structural variability, much of the reported data are organized into concise schemes and tables to facilitate comparison, and to underscore the key points of this review.
APA, Harvard, Vancouver, ISO, and other styles
8

Banik, Bimal Krishna. "Microwave-Induced Organic Reactions Toward Biologically Active Molecules." Current Medicinal Chemistry 26, no. 24 (October 11, 2019): 4492–94. http://dx.doi.org/10.2174/092986732624190927114808.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Piletsky, S. A., E. V. Piletska, T. A. Sergeyeva, I. A. Nicholls, D. Weston, and A. P. F. Turner. "Synthesis of biologically active molecules by imprinting polymerisation." Biopolymers and Cell 22, no. 1 (January 20, 2006): 63–67. http://dx.doi.org/10.7124/bc.00071c.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Setchenkov, M. S., S. I. Usmanova, Yu G. Afanas’eva, and R. S. Nasibullin. "Complexing of some biologically active molecules with phosphatidylcholine." Russian Physics Journal 52, no. 4 (April 2009): 417–20. http://dx.doi.org/10.1007/s11182-009-9235-2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "030401 Biologically Active Molecules"

1

Shortt, Marie Fiona. "Synthetic approaches to biologically active molecules." Thesis, Bangor University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282267.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Finn, P. W. "Computer studies on biologically active molecules." Thesis, University of Manchester, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374793.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

d'Ippolito, Giuliana. "Biologically active molecules from marine microalgae." Thesis, Open University, 2005. http://oro.open.ac.uk/54203/.

Full text
Abstract:
Diatoms are unicellular photosynthetic microalgae responsible for approximately 40% of marine primary productivity. This algal class has traditionally been regarded as providing the bulk of the food that sustains the marine food chain to top consumers and important fisheries. However, this beneficial role has recently been questioned on the basis of laboratory and field studies showing that although dominant zooplankton grazers such as copepods feed extensively on diatoms, the hatching success of eggs thus produced is seriously impaired. Short chain polyunsaturated aldehydes, such as 2,4,7-decatrienal and 2,4-decadienal, were correlated to the antiproliferative effect of diatoms on copepod reproduction. After establishing a method of analysis, the aldehyde profile of some ecologically relevant species of marine diatoms was assessed. The results showed that the production of aldehydes is species-specific. Detailed chemical analysis revealed the presence of fatty acid derivatives other than aldehydes such as hydroxyacids, ketoacids, oxoacids and epoxyalcohols, increasing the complexity of a chemical defence of diatoms mediated only by aldehydes. All these compounds belong to a class of compounds called oxylipins, that are oxygenated compounds biosynthesized from fatty acids by oxygenasecatalyzed oxygenation. Marine diatoms are able to produce the major antiproliferative oxylipins by a novel oxygenase-dependent oxidation of C16 fatty acids hexadecatrienoic acid (16:3 (w-4)) and hexadecatetrenoic acid (16:4 (w-1)), and C2o eicosapentaenoic acid (20:5 (w-3)). This process is triggered by lypolitic acyl hydrolase activity, that feeds the downstream lipoxygenase pathway. The ecological meaning of the oxylipin pathway in the diatom-copepod interactions is discussed, showing that attention should move from single compounds to complex biochemical process. The deleterious effect on copepod reproduction could be due to a biochemical process such as the generation of an high oxidative potential, rather than only by aldehydes or other secondary oxygenated products, that when present can co-occur to produce the final effect.
APA, Harvard, Vancouver, ISO, and other styles
4

Tunbridge, Gemma Ann. "Efficient synthesis of biologically active small molecules." Thesis, University of Bath, 2012. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.571862.

Full text
Abstract:
Pancratistatin and narciclasine are natural products isolated from Pancratium litorale1 and Narcissus poeticus2 respectively. Pancratistatin and Narciclasine have been shown to possess potent antitumour activity3 however they have never been widely exploited due to their limited availability from natural sources.4 Pancratistatin and narciclasine both contain a dihydroisoquinolinone framework. The work described in this thesis explores synthetic routes relating to this dihydroisoquinolinone framework, as well as comparable tetrahydroisoquinolines. An initial proposed synthetic route involved the synthesis of the dihydroisoquinolinone framework via the corresponding indanone. Indanones have also been shown to possess potential antitumour activity.5 A range of lactam and indanone analogues were synthesised and a selection were tested for biological activity against cancer cell lines. The most biologically active lactam analogue synthesised was lactam 170. Lactam 170 was synthesised via two steps from commercially available starting materials in an overall 51 % yield and was tested in the HT29 colon cancer cell line to give an IC50 value of 9 μM. Indanone 177 is an analogue of natural product indanocine and was synthesised via two steps in an overall 49 % yield. Analogue 177 was tested in the 60 cell line screen by the National Cancer Institute (NCI) to give a mean GI50 value of 1.29 μM and is currently under consideration for further testing. This thesis describes the synthesis and biological testing of the aforementioned compounds as well as an array of analogues.
APA, Harvard, Vancouver, ISO, and other styles
5

Gutierrez, Mauricio R. (Mauricio Roberto). "Size adjustable separation of biologically active molecules." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/34150.

Full text
Abstract:
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004.
Includes bibliographical references (p. 92-96).
Separation of biologically active molecules (BAM's) is a problem for the pharmaceutical and biotechnology industries. Current technologies addressing this problem require too many techniques, toxic additives, and time to filter desired materials. As a result, a new technology is needed. The objective of this thesis is to contribute towards the development of a new method for separating biologically active molecules in the size range of 0.5 nanometers to 500 nanometers. A normally open diaphragm valve is proposed that can control a gap formed by two flat surfaces. For accurate control of gap height, the valve was designed to ensure that the flat surfaces remain parallel during operation . Modularity was also part of design considerations to address issues of eventual biocompatibility breakdown specifically protein adsorption. Control of the gap has been achieved to increments of 1.8 nanometers.
by Mauricio R. Gutierrez.
S.M.
APA, Harvard, Vancouver, ISO, and other styles
6

Perez-Powell, Isabel Rose. "From fragments of prostanoids to biologically active molecules." Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.707737.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Jiang, Xiaohui. "Computational and NMR studies of biologically active molecules /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1998. http://wwwlib.umi.com/cr/ucsd/fullcit?p9906482.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Muller, Christophe. "The synthesis of biologically active molecules using organocobalt complexes." Thesis, Kingston University, 1997. http://eprints.kingston.ac.uk/20608/.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Giacomini, Elisa <1983&gt. "Innovative Strategies for the Synthesis of Biologically Active Small Molecules." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5537/.

Full text
Abstract:
The post genomic era, set the challenge to develop drugs that target an ever-growing list of proteins associated with diseases. However, an increase in the number of drugs approved every year is nowadays still not observed. To overcome this gap, innovative approaches should be applied in drug discovery for target validation, and at the same time organic synthetic chemistry has to find new fruitful strategies to obtain biologically active small molecules not only as therapeutic agents, but also as diagnostic tools to identify possible cellular targets. In this context, in view of the multifactorial mechanistic nature of cancer, new chimeric molecules, which can be either antitumor lead candidates, or valuable chemical tools to study molecular pathways in cancer cells, were developed using a multitarget-directed drug design strategy. According to this approach, the desired hybrid compounds were obtained by combining in a single chemical entity SAHA analogues, targeting histone deacetylases (HDACs), with substituted stilbene or terphenyl derivatives able to block cell cycle, to induce apoptosis and cell differentiation and with Sorafenib derivative, a multikinase inhibitor. The new chimeric derivatives were characterized with respect to their cytotoxic activity and their effects on cell cycle progression on leukemia Bcr-Abl-expressing K562 cell lines, as well as their HDACs inhibition. Preliminary results confirmed that one of the hybrid compounds has the desired chimeric profile. A distinct project was developed in the laboratory of Dr Spring, regarding the synthesis of a diversity-oriented synthesis (DOS) library of macrocyclic peptidomimetics. From a biological point of view, this class of molecules is extremely interesting but underrepresented in drug discovery due to the poor synthetic accessibility. Therefore it represents a valid challenge for DOS to take on. A build/couple/pair (B/C/P) approach provided, in an efficient manner and in few steps, the structural diversity and complexity required for such compounds.
APA, Harvard, Vancouver, ISO, and other styles
10

Ianni, Cristina <1980&gt. "Synthesis of Biologically Active Small Molecules: Different Approaches to Drug Design." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6403/.

Full text
Abstract:
In the past years, genome biology had disclosed an ever-growing kind of biological targets that emerged as ideal points for therapeutic intervention. Nevertheless, the number of new chemical entities (NCEs) translated into effective therapies employed in the clinic, still not observed. Innovative strategies in drug discovery combined with different approaches to drug design should be searched for bridge this gap. In this context organic synthetic chemistry had to provide for effective strategies to achieve biologically active small molecules to consider not only as potentially drug candidates, but also as chemical tools to dissect biological systems. In this scenario, during my PhD, inspired by the Biology-oriented Synthesis approach, a small library of hybrid molecules endowed with privileged scaffolds, able to block cell cycle and to induce apoptosis and cell differentiation, merged with natural-like cores were synthesized. A synthetic platform which joined a Domino Knoevenagel-Diels Alder reaction with a Suzuki coupling was performed in order to reach the hybrid compounds. These molecules can represent either antitumor lead candidates, or valuable chemical tools to study molecular pathways in cancer cells. The biological profile expressed by some of these derivatives showed a well defined antiproliferative activity on leukemia Bcr-Abl expressing K562 cell lines. A parallel project regarded the rational design and synthesis of minimally structurally hERG blockers with the purpose of enhancing the SAR studies of a previously synthesized collection. A Target-Oriented Synthesis approach was applied. Combining conventional and microwave heating, the desired final compounds were achieved in good yields and reaction rates. The preliminary biological results of the compounds, showed a potent blocking activity. The obtained small set of hERG blockers, was able to gain more insight the minimal structural requirements for hERG liability, which is mandatory to investigate in order to reduce the risk of potential side effects of new drug candidates.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "030401 Biologically Active Molecules"

1

Schlunegger, Urs Peter, ed. Biologically Active Molecules. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74582-9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Mahapatra, Debarshi Kar, and Sanjay Kumar Bharti. Biologically Active Small Molecules. New York: Apple Academic Press, 2022. http://dx.doi.org/10.1201/9781003283119.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Brenna, Elisabetta, ed. Synthetic Methods for Biologically Active Molecules. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527665785.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Hiroyasu, Aizawa, ed. Metabolic maps: Pesticides, environmentally relevant molecules, and biologically active molecules. San Diego, Calif: Academic Press, 2001.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

Necib, Y. Biochemical evaluation of lectins and other biologically active molecules. Salford: University of Salford, 1987.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Ion-exchange sorption and preparative chromatography of biologically active molecules. New York: Consultants Bureau, 1986.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

Samsonov, G. V. Ion-Exchange Sorption and Preparative Chromatography of Biologically Active Molecules. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-8908-8.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

P, Schlunegger Urs, and Schweizerischer Chemiker-Verband, eds. Biologically active molecules: Identification, characterization, and synthesis : proceedings of a Seminar on Chemistry on Biologically Active Compounds and Modern Analytical Methods, Interlaken, September 5-7, 1988. Berlin: Springer-Verlag, 1989.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

Schlunegger, Urs Peter. Biologically Active Molecules. Springer, 2011.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Aizawa, Hiroyasu. Metabolic Maps: Pesticides, Environmentally Relevant Molecules and Biologically Active Molecules. Elsevier Science & Technology Books, 2001.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "030401 Biologically Active Molecules"

1

Steglich, Wolfgang. "Some Chemical Phenomena of Mushrooms and Toadstools." In Biologically Active Molecules, 1–8. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74582-9_1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Hochuli, E. "Genetically Designed Affinity Chromatography Using a Novel Metal Chelate Absorbent." In Biologically Active Molecules, 217–39. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74582-9_10.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Fringeli, U. P. "Structure-Activity Relationship in Biomembranes Investigated by Infrared-ATR Spectroscopy." In Biologically Active Molecules, 241–52. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74582-9_11.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Anke, Timm, and Wolfgang Steglich. "β-Methoxyacrylate Antibiotics: From Biological Activity to Synthetic Analogues." In Biologically Active Molecules, 9–25. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74582-9_2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Vater, J. "Lipopeptides, an Interesting Class of Microbial Secondary Metabolites." In Biologically Active Molecules, 27–38. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74582-9_3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Caprioli, Richard M. "FAB: Basic Concepts and Practical Considerations." In Biologically Active Molecules, 39–58. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74582-9_4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Caprioli, Richard M. "Continuous-Flow Fast Atom Bombardment Mass Spectrometry." In Biologically Active Molecules, 59–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74582-9_5.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Caprioli, Richard M. "Coupling Chromatographic Techniques with FABMS for the Structural Analysis of Biological Compounds." In Biologically Active Molecules, 79–96. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74582-9_6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Morris, Howard R., Anne Dell, Maria Panico, Roy McDowell, and Ashraf Chatterjee. "The Application of High Mass FAB Mass Spectrometry to Molecular Biology." In Biologically Active Molecules, 97–147. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74582-9_7.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Krishnamurthy, Thaiya, Marguerite E. Brooks, Donald F. Hunt, Jeffrey Shabanowitz, Shuian Chen, and Terry Lee. "Identification of Active-Site in a Neurotoxic Snake Venom by Affinity Labelling and State-of-the-Art Tandem Mass Spectrometry Technology." In Biologically Active Molecules, 149–60. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74582-9_8.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "030401 Biologically Active Molecules"

1

Gutierrez, Mauricio R., and Kamal Youcef-Toumi. "Programmable Separation for Biologically Active Molecules." In ASME 2006 International Mechanical Engineering Congress and Exposition. ASMEDC, 2006. http://dx.doi.org/10.1115/imece2006-14141.

Full text
Abstract:
Separation of biologically active molecules (BAMs) is a problem for the pharmaceutical and biotechnology industries. Current technologies addressing this problem require too many techniques, toxic additives, and time to filter the desired materials. As a result, a new technology is needed. The objective of this work is to contribute to the development of a device that can separate 0.5 nm to 500 nm sized BAMs. A diaphragm valve is proposed that can control a gap created by two parallel flat surfaces. Position control is achieved by means of a piezoelectric actuator and a capacitive sensor. Modularity was also part of design considerations to address issues of eventual biocompatibility breakdown. Preliminary experiments indicate that gap separation can be controlled to increments of 0.2 nm.
APA, Harvard, Vancouver, ISO, and other styles
2

Karaliūnas, Mindaugas, Vytautas Jakštas, Kinan E. Nasser, Rimvydas Venckevičius, Andrzej Urbanowicz, Irmantas Kašalynas, and Gintaras Valušis. "Application of terahertz spectroscopy for characterization of biologically active organic molecules in natural environment." In SPIE Nanoscience + Engineering, edited by Manijeh Razeghi, Alexei N. Baranov, John M. Zavada, and Dimitris Pavlidis. SPIE, 2016. http://dx.doi.org/10.1117/12.2238242.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Usacheva, T. R., D. N. Kabirov, Lan Pham Thi, E. L. Isaeva, E. R. Aslambekova, and Z. S. Hasbulatova. "Inclusion Complexes of Cyclodextrins With Biologically Active Molecules in Water-Organic Solvents as a Promising Material for the Pharmaceutic Industry." In The International Conference “Health and wellbeing in modern society” (ICHW 2020). Paris, France: Atlantis Press, 2020. http://dx.doi.org/10.2991/ahsr.k.201001.036.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Lantushenko, Anastasia O., Yulia V. Mukhina, Kyrill A. Veselkov, David B. Davies, and Alexei N. Veselkov. "1H NMR analysis of complexation of hydrotropic agents nicotinamide and caffeine with aromatic biologically active molecules in aqueous solution." In SPIE Proceedings, edited by Galyna O. Puchkovska, Tatiana A. Gavrilko, and Olexandr I. Lizengevich. SPIE, 2004. http://dx.doi.org/10.1117/12.569621.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Pavesi, Andrea, Riccardo Vismara, Stefano Lorenzoni, Franco M. Montevecchi, and Gianfranco B. Fiore. "A Novel Bioreactor for In Vitro Electro-Mechanical Stimulation of Cardiac Constructs." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206650.

Full text
Abstract:
Cardiovascular diseases are the main cause of death and disability in Europe and in fact throughout the world [1]. Tissue engineering is a rapidly growing area that aims to create, repair and/or replace tissue and organs by using combinations of cells, biomaterials and biologically active molecules.
APA, Harvard, Vancouver, ISO, and other styles
6

Sadik, Mohamed M., Jianbo Li, Jerry W. Shan, David I. Shreiber, and Hao Lin. "Quantifying the Effects of Extracellular Conductivity on Transport During Electroporation." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53215.

Full text
Abstract:
Electroporation is an effective means to permeabilize the cell membrane and deliver biologically active molecules (such DNA, RNA, dyes, etc…) into the cell cytoplasm, while maintaining cell viability and functionality [1]. Despite extensive research, electroporation still suffers from major drawbacks such as high cell death and low delivery efficiency. In the past, studies focused mainly on permeabilization of the membrane during electroporation while transport of molecules from one side of the membrane to the other has been overlooked. Previous experimental work demonstrated an inverse relation between the electrical conductivity of the extracellular buffer and total concentration delivered into cells [2]. This inverse correlation suggests that additional molecular transport mechanisms, besides diffusion, govern the delivery into cells.
APA, Harvard, Vancouver, ISO, and other styles
7

Li, Jianbo, and Hao Lin. "A Pore Resistance Model and the Effect of Electrical Conductivity on Electroporation." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-204988.

Full text
Abstract:
Electroporation is an elegant means to gain access to the cytoplasm, and to deliver molecules into the cell while simultaneously maintaining viability and functionality. In this technique, electric pulses are applied to transiently permeabilize the cell membrane. Biologically active agents, such as DNA, RNA, and amino acids, can then enter the cell to perform tasks such as gene and cancer therapy. Despite wide applications, electroporation faces significant challenges to achieve simultaneous high delivery efficiency and cell viability. Addressing such challenges requires the development of good fundamental understanding and a quantitative prediction capability, and the current work is a step toward this goal.
APA, Harvard, Vancouver, ISO, and other styles
8

Shim, Youn Young, Timothy Tse, and Martin Reaney. "Biological Activities of Flaxseed Peptides (Linusorbs)." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/zrcc3198.

Full text
Abstract:
Flaxseed (Linum usitatissimum >L.) is gaining popularity in the food industry as a superfood due to its health-promoting properties. The flax plant synthesizes an array of biologically active cyclic peptides or linusorbs (LOs, a.k.a. cyclolinopeptides) from three or more ribosome-derived precursors. [1–9-NαC]-linusorb B3 and [1–9-NαC]-linusorb B2, suppress immunity, induce apoptosis in human epithelial cancer cell line (Calu-3) cells, and inhibit T-cell proliferation, but the mechanism of LOs action is unknown. Using gene expression analysis in nematode cultures and human cancer cell lines we have observed that LOs exert their activity, in part, through induction of apoptosis. Specific LOs’ properties include: 1) distribute throughout the body after flaxseed consumption; 2) induce heat shock protein (HSP) 70A production as an indicator of stress and addressed the issue in Caenorhabditis elegans (exposure of nematode cultures to [1–9-NαC]-linusorb B3 induced a 30% increase in production of the HSP 70A protein); 3) induce apoptosis in Calu-3 cells; and 4) modulate regulatory genes in microarray analysis. These diverse activities indicate that LOs might induce apoptosis in cancer cells or act as versatile platforms to deliver a variety of biologically active molecules for cancer therapy.
APA, Harvard, Vancouver, ISO, and other styles
9

Bennedsen, Jacob, and Karen Chang Yan. "On Continuum Based Multiscale Modelling of Engineered Soft Tissue Constructs." In ASME 2018 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/imece2018-88482.

Full text
Abstract:
Engineered tissue constructs are assembled through combining scaffolds, cells and biologically active molecules for restoring, maintaining, or improving damaged tissues or whole organs. Cells in engineered tissue constructs often experience mechanical forces during the fabrication process, maturation process, and under in vivo conditions. These mechanical forces/stimuli induce cellular responses and affect cell viability, proliferation, and differentiation. While it is critical to understand the mechanical milieu of cells in tissue constructs, it is also extremely challenging due to the time and length scale span. Multiscale modeling approaches have been emerged to provide linkage among different length scale. One of the approaches is continuum based multiscale modeling to link organ, tissue and cellular levels. A representative volume element (RVE) with periodic or random microstructure serves as a vehicle to connect different length scales. This study focuses on effects of RVE selection, microstructure, and boundary conditions on the mechanical environment at cellular level. In particular, cell embedded alginate tissue constructs were studied. Hyperelastic models were used for modeling alginate and cells. Multi-cellular FE models were generated. The results of the average properties and the stress/strain experienced by cells were compared under different conditions.
APA, Harvard, Vancouver, ISO, and other styles
10

Libby, Peter, Stephen J. C. Warner, and Louis K. Birinyi. "THE VESSEL WALL AS A SOURCE OF VASORHGOLATORY AND IMMDNOSTIMOLATORY CYTOKINES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643982.

Full text
Abstract:
The cytokines Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF, also known as cachectin) exhibit multiple effects on circulating blood cells and cells of the blood vessel wall. For example, these mediators elicit a coordinated Drogram of functions of endothelial cells (EC) that promotes blood coagulation and thrombosis, and lead to clot stabilization. Furthermore, IL-1 and TNF promote adherence to vascular endothelium of leukocytes of many classes.Thus, these cytokines are likely to be involved in signaling the pathologic changes in blood vessels that characterize a number of inflammatory or infectious processes. These two cytokines were originally isolated frcm activated human mononuclear phagocytes, hence their comnon designation as monokines and the terminology "interleukin". However, recent findings have broadened this concept considerably. It is now clear that many cell types can produce IL-1-1ike activity.Several groups showed that human vascular EC can secrete material that stimulates proliferation of thymocytes incubated with suboptima1 doses of the mitogenic lectin phytohemagglutinin, a typical acitivty of IL-1 (thymocyte costimulation).Two related but distinct genes cloned frcm human peripheral blood monocytes encode IL-1 molecules. In human blood monocytes stimulated with bacterial lioopolysaccharide (LPS) IL-1 beta (pi ∼ 7) is the major form expressed while IL-1 alpha (pi ∼ 5) is the less abundant species secreted by human monocytes under these conditions. We found that EC and smooth muscle cells (SMC) isolated from adult human vessels can express these same IL-1 genes. LPS, a standard stimulus to IL-1 secretion in the monocyte, caused accumulation of IL-1 beta mRNA in both vascular cell types. Endothelial cells frcm adult human vessels also contained IL-1 alpha mRNA when treated with LPS in the presence of cycloheximide and LPS-stimulated smooth muscle cells contained RNA that hybridized with an IL-1 alpha cDNA probe as well. Although both vascular cell types can transcribe these IL-1 genes, the time course of this response differs. LPS induced IL-1 beta mRNA production by SMC maximally at 4-6 hr., whereas maximal IL-1 induction by LPS in EC occured 1 day after initiation of the exposure. Actinanycin D (1 ug/ml) blocked 3H-uridine incorporation into macromolecules by > 95% in both EC & SMC, and prevented the LPS-induced increases in IL-1 mRNA levels in these cells. This result suggests that this potentially injurious stimulus causes IL-1 mRNA accumulation by an increase in rates of transcription. These LPS-induced increases in IL-1 mRNA levels corresponded to production of biologically active IL-1 determined as thymocyte costimulation activity. Interestingly, gel filtration experiments revealed a molecular weight of around 22kD for both SMC and EC-derived IL-1 secreted into culture medium in response to LPS. This molecular weight contrasts with the 17 kD species which is the fully processed product secreted frcm activated human monocytes. A possible explanation for this disparity is that the vascular cells secrete a partially processed intermediate form of mature IL-1. Other stimuli for IL-1 mRNA accumulation and secretion of biological activity include TNF and IL-1 itself. Recombinant human INF (≥ 10 ng/ml) increased IL-1 beta mRNA levels in EC & SMC, and caused the EC & SMC to release IL-1-1 ike thymocyte costimulation activity. Of interest is the recent observation that IL-1 itself can stimulate expression of IL-rl genes in vascular wall cells. Both IL-1 aloha and beta can increase IL-1 beta mRNA content in EC & SMC. Hris observation was confirmed with homogenous IL-1 prepared by recombinant DNA technologies (rIL-1). These findings raise the possibility of a novel positive feedback loop in vascular pathophysiology. We also found that rIL-1 alpha or beta also induced the production of prostaglandin E2 (PGE2) by both vascular SMC & EC. This prostanoid, induced by IL-1, inhibits thymocyte _ proliferation. Thus, IL-1 not only induced its own expression but increased production of this immunosuppressive prostanoid. This mechanism provides a potential negative control loop in regulation of the local immune response in blood vessels. Vie conclude that these cells of the blood vessel wall are a source of the potent vasoregulatory and immune mediators IL-1 alpha and beta. Since IL-1 influences the thrombotic, hemostatic, and fibrinolytic functions of endothelium, as well as other responses to acute injury, our findings suggest novel local control mechanisms that may be important in a variety of pathologic states.
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "030401 Biologically Active Molecules"

1

López-Valverde, Nansi, Javier Aragoneses, Antonio López-Valverde, Cinthia Rodríguez, and Juan Manuel Aragoneses. Role in the osseointegration of titanium dental implants, of bioactive surfaces based on biomolecules: A systematic review and meta-analysis of in vivo studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2022. http://dx.doi.org/10.37766/inplasy2022.6.0076.

Full text
Abstract:
Review question / Objective: Does the bioactive surface of titanium dental implants, based on biomolecules, influence osseointegration?. The aim of our study was to evaluate the role and efficacy of bioactive surfaces in osseointegration. Our review study limited the research interest to titanium dental implants coated with a biomolecule, i.e., an organic molecule produced by a living organism. Condition being studied: In recent years, much attention has been paid to topographical modifications of dental implant surfaces, as well as to their coating with biologically active substances.a bioactive surface is one capable of achieving faster and higher quality osseointegration, shortening waiting times and solving situations of poor bone quality. Molecules that can be applied for bioactive purposes include bioceramics, ions and biomolecules. Collagen and bone morphogenetic protein have been suggested as bone stimulating agents. Biofunctionalization of the implant surface with a biomimetic active peptide has also been shown to result in a significant increase in bone-to-implant ratios and an increase in peri-implant bone density.
APA, Harvard, Vancouver, ISO, and other styles
2

Kapulnik, Yoram, and Donald A. Phillips. Isoflavonoid Regulation of Root Bacteria. United States Department of Agriculture, January 1996. http://dx.doi.org/10.32747/1996.7570561.bard.

Full text
Abstract:
The overall objective of this project was to develop a conceptual framework for enhancing root colonization by beneficial bacteria. To accomplish this aim we tested the hypothesis that production and excretion of the plant phytoalexin medicarpin can be used for creation of a special niche along the legume roots, where beneficial microorganism, such as rhizobium, will have a selective advantage. On the Israeli side it was shown that higher medicarpin levels are exuded following the application of Rhizobium meliloti to the rhizosphere but the specific biochemical pathway governing medicarpin production was not induced significantly enough to support a constant production and excretion of this molecule to the rhizosphere. Furthermore, pathogenic bacteria and chemical elicitors were found to induce higher levels of this phytoalexin and it became important to test its natural abundance in field grown plants. On the US side, the occurrence of flavonoids and nucleosides in agricultural soils has been evaluated and biologically significant quantities of these molecules were identified. A more virulent Agrobacterium tumefaciens strain was isolated from alfalfa (Medicago sativa L.) which forms tumors on a wide range of plant species. This isolate contains genes that increase competitive colonization abilities on roots by reducing the accumulation of alfalfa isoflavonoids in the bacterial cells. Following gene tagging efforts the US lab found that mutation in the bacterial efflux pump operons of this isolate reduced its competitive abilities. This results support our original hypothesis that detoxification activity of isoflavenoids molecules, based on bacterial gene(s), is an important selection mechanism in the rhizosphere. In addition, we focused on biotin as a regulatory element in the rhizosphere to support growth of some rhizosphere microorganisms and designed a bacterial gene construct carrying the biotin-binding protein, streptavidin. Expressing this gene in tobacco roots did not affect the biotin level but its expression in alfalfa was lethal. In conclusion, the collaborative combination of basic and applied approaches toward the understanding of rhizosphere activity yielded new knowledge related to the colonization of roots by beneficial microorganisms in the presence of biological active molecules exuded from the plant roots.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic '030401 Biologically Active Molecules' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography