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Li, G., X. Tang, X. Gao, J. P. Huang, J. Chen, and J. Lu. "POINTING ANGLE CALIBRATION OF ZY3-02 SATELLITE LASER ALTIMETER USING TERRAIN MATCHING." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLII-1/W1 (May 31, 2017): 205–10. http://dx.doi.org/10.5194/isprs-archives-xlii-1-w1-205-2017.
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After GLAS (Geo-science Laser Altimeter System) loaded on the ICESat (Ice Cloud and land Elevation Satellite), satellite laser altimeter attracts more and more attention. ZY3-02 equipped with the Chinese first satellite laser altimeter has been successfully launched on 30<sup>th</sup> May, 2016. The geometric calibration is an important step for the laser data processing and application. The method to calculate the laser pointing angle error based on existed reference terrain data is proposed in this paper. The public version terrain data, such as 90m-SRTM and 30m-AW3D30, can be used to estimate the pointing angle of laser altimeter. The GLAS data with simulated pointing error and actual ZY3-02 laser altimetry data is experimented to validate the algorithm. The conclusion will be useful for the future domestic satellite laser altimeter.
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Chen, X., L. Zhang, Y. Wang, R. Li, M. Yang, and L. Gao. "Identification of key target genes and pathway analysis in nonalcoholic fatty liver disease via integrated bioinformatics analysis." Balkan Journal of Medical Genetics 25, no. 1 (June 1, 2022): 25–34. http://dx.doi.org/10.2478/bjmg-2022-0006.
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Abstract Purpose This study aimed at exploring the mechanisms underlying nonalcoholic fatty liver disease (NAFLD) and developing new diagnostic biomarkers for nonalcoholic steatohepatitis (NASH). Methods The microarray dataset GES83452 was downloaded from the NCBI-GEO database, and the differentially expressed RNAs (DERs) were screened between the NAFLD and non-NAFLD samples of the baseline and 1-year follow-up time point group based on the Limma package. Results A total of 561 DERs (268 downregulated and 293 upregulated) were screened in the baseline time point group, and 1163 DERs (522 downregulated and 641 upregulated) were screened in the 1-year follow-up time point group. A total of 74 lncRNA–miRNA pairs and 523 miRNA–mRNA pairs were obtained in order to construct a lncRNA–miRNA–mRNA regulatory network. Subsequently, functional enrichment analysis revealed 28 GO and 9 KEGG pathways in the ceRNA regulatory network. LEPR and CXCL10 are involved in the Cytokine–cytokine receptor interaction (P = 1.86E-02), and the FOXO1 is involved in both the insulin signaling pathway (P = 1.79E-02) and the pathways in cancer (P = 2.87E-02). Conclusion LEPR, CXCL10, and FOXO1 were the characteristic target genes for NAFLD.
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Xie, Guangqi, Mi Wang, Zhiqi Zhang, Shao Xiang, and Luxiao He. "Near Real-Time Automatic Sub-Pixel Registration of Panchromatic and Multispectral Images for Pan-Sharpening." Remote Sensing 13, no. 18 (September 14, 2021): 3674. http://dx.doi.org/10.3390/rs13183674.
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This paper presents a near real-time automatic sub-pixel registration method of high-resolution panchromatic (PAN) and multispectral (MS) images using a graphics processing unit (GPU). In the first step, the method uses differential geo-registration to enable accurate geographic registration of PAN and MS images. Differential geo-registration normalizes PAN and MS images to the same direction and scale. There are also some residual misalignments due to the geometrical configuration of the acquisition instruments. These residual misalignments mean the PAN and MS images still have deviations after differential geo-registration. The second step is to use differential rectification with tiny facet primitive to eliminate possible residual misalignments. Differential rectification corrects the relative internal geometric distortion between PAN and MS images. The computational burden of these two steps is large, and traditional central processing unit (CPU) processing takes a long time. Due to the natural parallelism of the differential methods, these two steps are very suitable for mapping to a GPU for processing, to achieve near real-time processing while ensuring processing accuracy. This paper used GaoFen-6, GaoFen-7, ZiYuan3-02 and SuperView-1 satellite data to conduct an experiment. The experiment showed that our method’s processing accuracy is within 0.5 pixels. The automatic processing time of this method is about 2.5 s for 1 GB output data in the NVIDIA GeForce RTX 2080Ti, which can meet the near real-time processing requirements for most satellites. The method in this paper can quickly achieve high-precision registration of PAN and MS images. It is suitable for different scenes and different sensors. It is extremely robust to registration errors between PAN and MS.
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Wood, AO, Dan, and Jeffrey Hedenquist. "Mineral Exploration: Discovering and Defining Ore Deposits." SEG Discovery, no. 116 (January 1, 2019): 1–22. http://dx.doi.org/10.5382/geo-and-mining-02.
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Editor’s note: The Geology and Mining series, edited by Dan Wood and Jeffrey Hedenquist, is designed to introduce early-career professionals and students to a variety of topics in mineral exploration, development, and mining, in order to provide insight into the many ways in which geoscientists contribute to the mineral industry. Abstract For economic geologists, mineral exploration has a specific objective: the discovery of mineral concentrations that can be recovered economically to provide resources essential for society. This was achieved consistently until the first decade of the current century, but exploration since then has been wealth destructive. This outcome is a major issue for the mining industry unless reversed. We believe the technologies presently used to discover ore deposits will be as useful in making future discoveries as they were previously. However, we argue that a new approach is required in how exploration is conducted and in how these and emerging technologies are applied. The required changes in approach include improved business models for conducting exploration and acceptance that fewer deposits are likely to be discovered near the surface. We argue that discovery of deeper deposits will be facilitated if exploration teams (1) seek to identify subtle evidence of mineralized rock recognizable within 500 m of the surface, (2) conduct follow-up investigations with a clear understanding of the volumetric dimensions of the discovery target, and (3) drill boldly as a critical exploration tool. We propose that improving the way geoscientists think when exploring—being more predictive—is the immediate key to increasing the number of discoveries.
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Jaafar, Juliana Rosmidah, Sheau Tsuey Chong, Khadijah Alavi, and Balan Rathakrishnan. "Pemahaman identiti diri daripada perspektif penderma darah ulangan berkala." Malaysian Journal of Society and Space 13, no. 3 (August 29, 2017): 11–18. http://dx.doi.org/10.17576/geo-2017-1303-02.
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Mahmud, Abdul Rahman, Zaini Sakawi, and Khairul Nizam Abdul Maulud. "Analisa terhadap kaedah pengulasan laporan Penilaian Kesan kepada Alam Sekeliling di Malaysia." Malaysian Journal of Society and Space 13, no. 4 (November 30, 2017): 11–21. http://dx.doi.org/10.17576/geo-2017-1304-02.
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Ishak, Suraiya, Ahmad Raflis Che Omar, Fahruddin Mustafa Al Bakri, and Lokhman Hakim Osman. "Amalan pembelajaran dan kesannya terhadap pembentukan pengetahuan serta kemahiran perniagaan dalam kalangan Generasi Z." Malaysian Journal of Society and Space 14, no. 1 (February 28, 2018): 15–28. http://dx.doi.org/10.17576/geo-2018-1401-02.
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Mahmud, Mastura, and Nur Hidayah Ahmad. "Peristiwa El Nino, keragaman hujan dan potensi Southern Oscillation Index untuk peramalan kualiti udara di Malaysia." Malaysian Journal of Society and Space 14, no. 2 (May 29, 2018): 13–25. http://dx.doi.org/10.17576/geo-2018-1402-02.
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Abdul Aziz, Nik Norazira. "Intimacy in marital relationship: Effect of internet usage." Malaysian Journal of Society and Space 14, no. 3 (August 27, 2018): 14–23. http://dx.doi.org/10.17576/geo-2018-1403-02.
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Hari Singh, Nirmal Kaur, Lai Wei Sieng, and Mohd Nasir Mohd Saukani. "Impact of education levels on economic growth in Malaysia: A gender base analysis." Malaysian Journal of Society and Space 14, no. 4 (November 22, 2018): 13–26. http://dx.doi.org/10.17576/geo-2018-1404-02.
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Tandoh, Kwesi Z., Kwadwo A. Kusi, Timothy N. Archampong, Isaac Boamah, and Osbourne Quaye. "Hepatitis B infection outcome is associated with novel human leukocyte antigen variants in Ghanaian cohort." Experimental Biology and Medicine 245, no. 9 (April 29, 2020): 815–22. http://dx.doi.org/10.1177/1535370220921118.
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Chronic hepatitis B infection is an important medical problem in sub-Saharan Africa. With increasing concerns of dwindling access to needed care, increasing cost of treatment, and rising prevalence of dire outcomes like liver cirrhosis and hepatocellular cancer, the need to determine the genetic associations underpinning hepatitis B virus persistence or clearance in a population comes to the fore. Genetic association studies have suggested a variation in human leukocyte antigen alleles associated with hepatitis B virus outcome along geo-ethnic lines. We investigated the association of human leukocyte antigen alleles to hepatitis B virus outcome against this backdrop. We used targeted next generation sequencing to type the human leukocyte antigen class I and II alleles of 173 study participants. These comprised of 92 cases with chronic hepatitis B infection and 81 healthy controls with serological evidence of naturally cleared hepatitis B virus infection. We have identified human leukocyte antigen alleles associated with hepatitis B virus clearance and persistence for the first time in a Ghanaian population. The class 1 allele C*16:01 (odds ratio (OR) = 3.4, confidence interval (CI) = 1.6–7.0, P-value = 0.01) was associated with hepatitis B virus persistence. Four class I alleles and one class II allele: A*34:02 (OR = 0.1, CI = 0.04–0.2, P-value = 3.4e-05), A*74:01 (OR = 0.3, CI = 0.2–0.7, P-value = 0.0135), B*13:02 (OR = 0.04, CI = 0.01–0.2, P-value = 0.000172), C*08:04 (OR = 0.06, CI = 0.01–0.2, P-value = 7.83e-05), and DRB1*08:04 (OR = 0.2, CI = 0.03–0.27, P-value = 0.000252) were associated with hepatitis B virus clearance. Our data show that previously reported human leukocyte antigen alleles associations to hepatitis B virus outcome are not found in this Ghanaian study. This study has therefore identified human leukocyte antigen types that are associated with either hepatitis B virus persistence or clearance and highlights the importance of geo-ethnic pivoted studies in determining the genetic associations to acute hepatitis B virus infection outcome. Impact statement Genetic association studies can determine the effect size of gene loci on disease outcomes. In the arena of HBV infections, HLA alleles that associate with HBV outcomes can be used in clinical management decisions. This potential translational utility can shape the future management of HBV infections by identifying at-risk individuals and tailoring medical interventions accordingly. This precision medicine motif is currently only a nascent idea. However, it has stakes that may well override the current “wait and see” approach of clinical management of HBV infections. Here, we have identified HLA alleles associated with HBV outcome in a Ghanaian cohort. Our findings support the motif that HLA alleles associate with HBV outcome along geo-ethnic lines. This buttresses the need for further population pivoted studies. In the long term, our findings add to efforts towards the development of an HLA molecular-based algorithm for predicting HBV infection outcomes.
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Zhang, Mengyuan, Zhike Zhou, Zhouyang Liu, Fangxi Liu, and Chuansheng Zhao. "Exploring the potential biomarkers for prognosis of glioblastoma via weighted gene co-expression network analysis." PeerJ 10 (January 18, 2022): e12768. http://dx.doi.org/10.7717/peerj.12768.
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Background Glioblastoma (GBM) is the most common malignant tumor in the central system with a poor prognosis. Due to the complexity of its molecular mechanism, the recurrence rate and mortality rate of GBM patients are still high. Therefore, there is an urgent need to screen GBM biomarkers to prove the therapeutic effect and improve the prognosis. Results We extracted data from GBM patients from the Gene Expression Integration Database (GEO), analyzed differentially expressed genes in GEO and identified key modules by weighted gene co-expression network analysis (WGCNA). GSE145128 data was obtained from the GEO database, and the darkturquoise module was determined to be the most relevant to the GBM prognosis by WGCNA (r = − 0.62, p = 0.01). We performed enrichment analysis of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) to reveal the interaction activity in the selected modules. Then Kaplan-Meier survival curve analysis was used to extract genes closely related to GBM prognosis. We used Kaplan-Meier survival curves to analyze the 139 genes in the darkturquoise module, identified four genes (DARS/GDI2/P4HA2/TRUB1) associated with prognostic GBM. Low expression of DARS/GDI2/TRUB1 and high expression of P4HA2 had a poor prognosis. Finally, we used tumor genome map (TCGA) data, verified the characteristics of hub genes through Co-expression analysis, Drug sensitivity analysis, TIMER database analysis and GSVA analysis. We downloaded the data of GBM from the TCGA database, the results of co-expression analysis showed that DARS/GDI2/P4HA2/TRUB1 could regulate the development of GBM by affecting genes such as CDC73/CDC123/B4GALT1/CUL2. Drug sensitivity analysis showed that genes are involved in many classic Cancer-related pathways including TSC/mTOR, RAS/MAPK.TIMER database analysis showed DARS expression is positively correlated with tumor purity (cor = 0.125, p = 1.07e−02)), P4HA2 expression is negatively correlated with tumor purity (cor =−0.279, p = 6.06e−09). Finally, GSVA analysis found that DARS/GDI2/P4HA2/TRUB1 gene sets are closely related to the occurrence of cancer. Conclusion We used two public databases to identify four valuable biomarkers for GBM prognosis, namely DARS/GDI2/P4HA2/TRUB1, which have potential clinical application value and can be used as prognostic markers for GBM.
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Hussain, Muhammad Afaq, Zhanlong Chen, Run Wang, Safeer Ullah Shah, Muhammad Shoaib, Nafees Ali, Daozhu Xu, and Chao Ma. "Landslide Susceptibility Mapping using Machine Learning Algorithm." Civil Engineering Journal 8, no. 2 (February 1, 2022): 209–24. http://dx.doi.org/10.28991/cej-2022-08-02-02.
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Landslides are natural disasters that have resulted in the loss of economies and lives over the years. The landslides caused by the 2005 Muzaffarabad earthquake heavily impacted the area, and slopes in the region have become unstable. This research was carried out to find out which areas, as in Muzaffarabad district, are sensitive to landslides and to define the relationship between landslides and geo-environmental factors using three tree-based classifiers, namely, Extreme Gradient Boosting (XGBoost), Random Forest (RF), and k-Nearest Neighbors (KNN). These machine learning models are innovative and can assess environmental problems and hazards for any given area on a regional scale. The research consists of three steps: Firstly, for training and validation, 94 historical landslides were randomly split into a proportion of 7/3. Secondly, topographical and geological data as well as satellite imagery were gathered, analyzed, and built into a spatial database using GIS Environment. Nine layers of landslide-conditioning factors were developed, including Aspect, Elevation, Slope, NDVI, Curvature, SPI, TWI, Lithology, and Landcover. Finally, the receiver operating characteristic (ROC) curve and the area under the ROC curve (AUC) value were used to estimate the model's efficiency. The area under the curve values for the RF, XGBoost, and KNN models are 0.895 (89.5%), 0.893 (89.3%), and 0.790 (79.0%), respectively. Based on the three machine learning techniques, the innovative outputs show that the performance of the Random Forest model has a maximum AUC value of 0.895, and it is more efficient than the other tree-based classifiers. Elevation and Slope were determined as the most important factors affecting landslides in this research area. The landslide susceptibility maps were classified into four classes: low, moderate, high, and very high susceptibility. The result maps are useful for future generalized construction operations, such as selecting and conserving new urban and infrastructural areas. Doi: 10.28991/CEJ-2022-08-02-02 Full Text: PDF
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Bhuiyan, Md Abul Ehsan, Chandi Witharana, Anna K. Liljedahl, Benjamin M. Jones, Ronald Daanen, Howard E. Epstein, Kelcy Kent, Claire G. Griffin, and Amber Agnew. "Understanding the Effects of Optimal Combination of Spectral Bands on Deep Learning Model Predictions: A Case Study Based on Permafrost Tundra Landform Mapping Using High Resolution Multispectral Satellite Imagery." Journal of Imaging 6, no. 9 (September 17, 2020): 97. http://dx.doi.org/10.3390/jimaging6090097.
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Deep learning (DL) convolutional neural networks (CNNs) have been rapidly adapted in very high spatial resolution (VHSR) satellite image analysis. DLCNN-based computer visions (CV) applications primarily aim for everyday object detection from standard red, green, blue (RGB) imagery, while earth science remote sensing applications focus on geo object detection and classification from multispectral (MS) imagery. MS imagery includes RGB and narrow spectral channels from near- and/or middle-infrared regions of reflectance spectra. The central objective of this exploratory study is to understand to what degree MS band statistics govern DLCNN model predictions. We scaffold our analysis on a case study that uses Arctic tundra permafrost landform features called ice-wedge polygons (IWPs) as candidate geo objects. We choose Mask RCNN as the DLCNN architecture to detect IWPs from eight-band Worldview-02 VHSR satellite imagery. A systematic experiment was designed to understand the impact on choosing the optimal three-band combination in model prediction. We tasked five cohorts of three-band combinations coupled with statistical measures to gauge the spectral variability of input MS bands. The candidate scenes produced high model detection accuracies for the F1 score, ranging between 0.89 to 0.95, for two different band combinations (coastal blue, blue, green (1,2,3) and green, yellow, red (3,4,5)). The mapping workflow discerned the IWPs by exhibiting low random and systematic error in the order of 0.17–0.19 and 0.20–0.21, respectively, for band combinations (1,2,3). Results suggest that the prediction accuracy of the Mask-RCNN model is significantly influenced by the input MS bands. Overall, our findings accentuate the importance of considering the image statistics of input MS bands and careful selection of optimal bands for DLCNN predictions when DLCNN architectures are restricted to three spectral channels.
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Onyelowe, Kennedy C., Ahmed M. Ebid, Hisham A. Mahdi, and Jair A. Baldovino. "Selecting the Safety and Cost Optimized Geo-Stabilization Technique for Soft Clay Slopes." Civil Engineering Journal 9, no. 2 (February 1, 2023): 453–64. http://dx.doi.org/10.28991/cej-2023-09-02-015.
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Slope failure poses a serious threat to the built environment as it is currently one of the fundamental contributors to climate change fears across the world, and this threatens the environmental goals of the United Nations Sustainable Development Goals (UNSDGs) for the year 2050. In this research paper, an optimized geo-stabilization numerical model has been developed with a Plaxis 2D code under safety and cost optimization considerations for a 37 m high slope embankment located on a soft clay watershed with an infinite extension. The site was prepared with four monitoring wells installed at 2.5 m, 7.5 m, 12.5 m, and 21.5 m from the foot of the slope to measure the water level conditions, and samples were collected and tested in the laboratory to determine the hydraulic and shear strength and modulus of the soil. Seven (7) different simulation alternatives were considered in terms of the model solutions to be deployed under dry and wet states, which were slope steep (angle) reduction (Alt-1), dewatering (Alt-2), jet grouting (Alt-3), jet grouting/dewatering (Alt-4), slope reduction/jet grouting (Alt-5), slope reduction/dewatering (Alt-6), and slope reduction/jet grouting/dewatering (Alt-7). The finite element model implementation of the alternatives showed that Alt-2, Alt-3, and Alt-4 had FOS of less than 1.5 and were omitted because their stability considerations did not meet the requirements for the normal operating conditions of a slope and also the short-term and long-term stability conditions according to the literature. Alternatives 1, 5, 6, and 7 with FOS above 1.5 were selected for further optimization considerations. Economic and sustainability factors were selected and considered based on the cost in line with current average market prices, constructability, reliability, and the environmental impact needed to achieve the required earthwork, jet grouting, dewatering, and selected combinations. Finally, the Alt-1 (FOS = 1.505), though not the cheapest, was selected as the optimal choice in terms of reliability, constructability, and environmental impact. However, Alt-6 (FOS = 1.520) and Alt-7 (FOS = 1.508) are the most economical but ranked low in reliability and environmental impact considerations. Doi: 10.28991/CEJ-2023-09-02-015 Full Text: PDF
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BENSCHOP, J., M. A. STEVENSON, J. DAHL, R. S. MORRIS, and N. P. FRENCH. "Informing surveillance programmes by investigating spatial dependency of subclinicalSalmonellainfection." Epidemiology and Infection 137, no. 9 (February 19, 2009): 1348–59. http://dx.doi.org/10.1017/s0950268809002106.
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SUMMARYThe aim of this paper is to investigate local spatial dependency with regard toSalmonellaseropositivity in data from the Danish swine salmonellosis control programme and its application in informing surveillance strategies. We applied inhomogeneous and observed-differenceK-function estimation, and geo-statistical modelling to data from the Danish swine salmonellosis control programme. Slaughter-pig farm density showed large variation at both the country-wide and local level in Denmark (median 0·23, range 0·02–0·47 farms/km2). The spatial distribution of pig farms followed a random inhomogeneous Poisson process but was not aggregated. We found evidence for aggregation ofSalmonellacase farms over that of all farms at distances of up to 6 km and semivariogram analyses ofSalmonellaseropositivity revealed spatial dependency between pairs of farms up to 4 km apart. The strength of the spatial dependency was positively associated with slaughter-pig farm density. We proposed sampling more intensively those farms within a 4 km radius of farms that were identified with a highSalmonellastatus, and reduced sampling of farms that are within this radius of ‘Salmonella-free’ farms. Our approach has the potential to optimize sampling strategies while maintaining consumer confidence in food safety and also has potential to be used for other zoonotic disease surveillance systems.
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Latifi, Fatima Ezzahraa, Khadija Baba, Ghizlan Ardouz, and Latifa EL Bouanani. "Evaluation of Liquefaction Potential based on Cone Penetration Test (CPT) and Semi-empirical Methods." Civil Engineering Journal 9, no. 2 (February 1, 2023): 423–36. http://dx.doi.org/10.28991/cej-2023-09-02-013.
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The phenomenon of soil liquefaction can be an induced effect of earthquake shaking where the saturated soil loses some or all of its bearing capacity and stiffness. Likewise, the increase of water pressure in the soil pores under the seismic wave causes a decrease of the shear strength. As a result, the soil becomes liquefied and susceptible to producing permanent deformations. The phenomenon of liquefaction is generally unpredictable, and neglecting it can influence the stability of structures and infrastructure foundations. Since the 1964 Alaska and Niigata earthquakes, more research works have been conducted to assess land liquefaction vulnerability. This study is undertaken in this field, whose objective, on the one hand, is to signal the phenomenon of liquefaction in the north of Morocco as a geo-technical part known for its instability and, on the other hand, to study the semi-empirical methods to adequately evaluate the liquefaction potential while specifying the most appropriate method for our case study. Similarly, the study is based on data derived from experimental results of in-situ tests applied to the embankment crossing the valley of "Oued Gharifa" on a high-speed rail line section from KP 228+400 to KP 229+375. Moreover, this research aims to show and discuss the evaluation of liquefaction potential of the experimental results of the CPT (cone penetration test) using three semi-empirical methods, namely the Juang method, the Olsen method, and the Robertson method. In doing so, we are going to compare the application results of the three semi-empirical methods in light of evaluating the liquefaction likelihood of the studied area, taking into account the nature of the soil, the variation of the safety coefficient, and the liquefaction potential for each method as well. Doi: 10.28991/CEJ-2023-09-02-013 Full Text: PDF
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Sequeira, R. V., A. Shields, A. Moore, and P. De Barro. "Inter-seasonal population dynamics and pest status of Bemisia tabaci (Gennadius) biotype B in an Australian cropping system." Bulletin of Entomological Research 99, no. 4 (December 9, 2008): 325–35. http://dx.doi.org/10.1017/s000748530800638x.
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AbstractBemisia tabaci, biotype B, commonly known as the silverleaf whitefly (SLW) is an alien species that invaded Australia in the mid-90s. This paper reports on the invasion ecology of SLW and the factors that are likely to have contributed to the first outbreak of this major pest in an Australian cotton cropping system. Population dynamics of SLW within whitefly-susceptible crop (cotton and cucurbit) and non-crop vegetation (sowthistle, Sonchus spp.) components of the cropping system were investigated over four consecutive growing seasons (September–June) 2001/02–2004/05 in the Emerald Irrigation Area (EIA) of Queensland, Australia. Based on fixed geo-referenced sampling sites, variation in spatial and temporal abundance of SLW within each system component was quantified to provide baseline data for the development of ecologically sustainable pest management strategies. Parasitism of large (3rd and 4th instars) SLW nymphs by native aphelinid wasps was quantified to determine the potential for natural control of SLW populations. Following the initial outbreak in 2001/02, SLW abundance declined and stabilised over the next three seasons. The population dynamics of SLW is characterised by inter-seasonal population cycling between the non-crop (weed) and cotton components of the EIA cropping system. Cotton was the largest sink for and source of SLW during the study period. Over-wintering populations dispersed from weed host plant sources to cotton in spring followed by a reverse dispersal in late summer and autumn to broad-leaved crops and weeds. A basic spatial source-sink analysis showed that SLW adult and nymph densities were higher in cotton fields that were closer to over-wintering weed sources throughout spring than in fields that were further away. Cucurbit fields were not significant sources of SLW and did not appear to contribute significantly to the regional population dynamics of the pest. Substantial parasitism of nymphal stages throughout the study period indicates that native parasitoid species and other natural enemies are important sources of SLW mortality in Australian cotton production systems. Weather conditions and use of broad-spectrum insecticides for pest control are implicated in the initial outbreak and on-going pest status of SLW in the region.
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Porciúncula, Rogério de Jesus, and Luiz Rogério Bastos Leal. "GEOELETRIC CARACTERIZATION FOR IMPLANTATION A LANDFILL IN SIMÕES FILHO, BAHIA, BRAZIL." Brazilian Journal of Geophysics 37, no. 4 (December 1, 2019): 481. http://dx.doi.org/10.22564/rbgf.v37i4.2028.
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ABSTRACT. The present study brings the results from the integration of applying a geoelectrical method and direct investigation methods in the qualitative and quantitative characterization of the geological-geotechnical environment. The purpose was to establish a local hydrostratigraphic model, in order to survey information that would aid in the implementation of cells for the final destination of urban solid waste over the sediments of the São Sebastião Formation, in Simões Filho, Bahia, Brazil. Twelve vertical electrical soundings, two SPT soundings and one geological sounding composed the quantitative surveys and techniques used. Unidimensional inversions presented mean error of 4.1%. Bidimensional inversions presented 5.7% mean error. Lower-value geoelectrical facies (< 1,000 Ohm.m) were attributed to occurrences between the silt and clay fraction, while higher-value facies (> 1,000 Ohm.m) corresponded to occurrence between the silt and sand fraction. The hydrostratigraphic model included a confined aquifer, represented by a succession of alternating sandy and clay-rich layers with subhorizontal contact, often laterally truncated, with at least two thick layers of clay occupying the first 100 m in depth. Moreover, water occurred in permeable porous layers, between depths of 40 and 50 m, approximately. Regarding the degree of compactness, soils were classified as medium to hard.Keywords: final waste disposal cells, geoelectrical method, hydrostratigraphic model.RESUMO. O presente estudo traz os resultados da integração do método geo-elétrico a métodos diretos de investigação, utilizados para caracterização qualitativa e quantitativa do ambiente geológico-geotécnico. O propósito foi estabelecer o modelo hidro-estratigráfico local, de modo a levantar informações que auxiliem na implantação de células de destinação final de resíduos sólidos urbanos sobre os sedimentos da Formação São Sebastião, no município de Simões Filho, Bahia. 12 sondagens elétricas verticais, 02 sondagens SPTs e 01 sondagem geológica compuseram o quantitativo de ensaios e técnicas utilizados. As inversões unidimensionais apresentaram erro médio de 4,1%. As inversões bidimensionais, de 5,7%. Os fácies geo-elétricos de menores valores (<1000 Ohm.m) estão atribuídos à ocorrência entre a fração síltica a argilosa, e de maiores valores (>1000 Ohm.m), à ocorrência entre a fração síltica a arenosa. O modelo hidro-estratigráfico inclui um aquífero do tipo confinado, representado por uma sucessão de camadas arenosas e argilosas intercaladas em contato subhorizontal, por vezes truncadas lateralmente, com no mínimo duas camadas espessas de argila nos primeiros 100 m de profundidade, e ocorrência de água, quando em camadas permoporosas, entre as cotas de 40 a 50 m, aproximadamente. Quanto ao estado de compacidade, nos primeiros 10 m de profundidade, os solos são classificados como médio a rijo.Palavras-chave: células de disposição final de resíduos, método geoelétrico, modelo hidroestratigráfico.
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Zia, Sahar, Muhammad Nasar-u-Minallah, Nikhat Zahra, and Aysha Hanif. "The Effect Of Urban Green Spaces In Reducing Urban Flooding In Lahore, Pakistan, Using Geospatial Techniques." GEOGRAPHY, ENVIRONMENT, SUSTAINABILITY 15, no. 3 (October 4, 2022): 47–55. http://dx.doi.org/10.24057/2071-9388-2021-135.
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Urban Green Spaces (UGS) curtails all environmental issues and ensure an eco-friendly locale. Similarly, the emergence of UGS is very helpful to cope with emerging urban flooding in cities by setting up the world standard of green space ratio (20 to 25 percent of the area) and green per capita (9m2 ) in a geographical area. Therefore, the present study is conducted to evaluate the causal effect relation of UGS with the frequency of urban flooding. For this purpose, 69 selected union councils are taken as a study area in District Lahore, Pakistan. The relation between UGS and the occurrence of floods is evaluated using geo-statistical and geospatial analysis techniques during the monsoon rainfalls from 2013 to 2019. Furthermore, the data sets of sore points (inundated areas), occurrences of urban flooding (number of event occurrences), green per capita, and green ratio are used. Results revealed that selected union councils in Lahore don’t have enough urban green spaces. There is only a 51 sq km area with adequate UGS that accounts for only 18 percent of the study area. The rest of the area does not meet the world standards of green area. There are some areas including Ravi town, Gulberg town, and Samanabad town with green per capita more than 4 green per capita. On the other hand, there are only 02 union councils including Race Course and Model Town that are comprised of a 20 percent green area. The findings of the study will be helpful for proper urban planning and strategies i.e. with greener structures.
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Yésou, Hervé, Pierre Chastanet, Jérôme Maxant, Claire Huber, Stephen Clandillon, Stéphanie Battiston, Catherine Proy, and Paul De Fraipont. "Contribution de l'imagerie Pléiades à la cartographie rapide des dégâts suite à des catastrophes majeures: retours d'expériences après deux ans d'actions de cartographie rapide localisées en Asie, en Afrique, en Europe et aux Caraïbes." Revue Française de Photogrammétrie et de Télédétection, no. 209 (January 29, 2015): 81–87. http://dx.doi.org/10.52638/rfpt.2015.236.
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Le lancement des deux satellites Pléiades 1A et 1B fin 2011 et 2012 a permis à la France de se doter de nouvelles capacités d'acquisition d'images optiques à très haute résolution, dans le domaine particulier de la gestion des crises mais aussi plus largement dans différentes thématiques d'Observation de la Terre. Les capacités et spécificités techniques de la Constellation Pléiades ouvrent de réelles opportunités pour la cartographie des dégâts suite à une catastrophe. Depuis 2012, le CNES, Airbus Defence and Space Geo-Intelligence et le SERTIT, ont combiné leurs efforts à plusieurs reprises pour assister les acteurs internationaux de la gestion de crise, optimisant les programmations des satellites Pléiades et analysant les images acquises. Différentes actions de cartographie réactive ont ainsi été menées, exploitant le potentiel de la Constellation Pléiades: inondations à Krymsk en Russie (07-2012), tremblement de terre dans la province iranienne d'Azerbaïdjan oriental (08-2012), inondations au Niger (08-2012), cyclone Sandy en Haïti (11-2012), typhon Bopha aux Philippines (12-2012), cyclone Evan à Wallis et Futuna (12-2012), cyclone Haruna à Madagascar (02-2013), inondations au Sénégal (08-2013), le cyclone Bejisa sur l'île de la Réunion (01-2014). Les premiers retours d'expérience sont plus que positifs, démontrant que les le système Pléiades est particulièrement adapté à la gestion de crise dans sa phase d'urgence. La très haute résolution spatiale permet une cartographie précise essentielle dans les zones critiques telles que les paysages urbains ou les infrastructures sensibles, la possibilité d'acquisition journalière et la livraison rapide des données constituent des atouts majeurs pour les applications spatiales, notamment pour la gestion des risques.
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AlSultan, Dalal, Alex J. Eustace, Stephen F. Madden, and John Crown. "Abstract P5-02-10: In-silico approaches that detect immune contexture to trastuzumab response in neo-adjuvant studies." Cancer Research 83, no. 5_Supplement (March 1, 2023): P5–02–10—P5–02–10. http://dx.doi.org/10.1158/1538-7445.sabcs22-p5-02-10.
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Abstract Introduction: Computational approaches have aided in estimating cellular composition of the tumour microenvironment. The evaluation of immune composition in tumours before treatment may predict pathologic complete response (pCR). The aim of the study was to perform a meta-analysis of HER2-positive breast cancer subjects who received neoadjuvant trastuzumab to detect associations between immune cells measured by CIBERSORT and ESTIMATE and pCR. Methods: PubMed was used to identify transcriptomic data of HER2-positive breast cancer patients who received neoadjuvant trastuzumab. Baseline data from eight neoadjuvant studies (N=338) was downloaded from GEO. Data from each study was background corrected and quantile normalised using ‘limma’ or ‘oligo’ packages in R. Immune profiles per sample was generated using computational softwares CIBERSORT and ESTIMATE, and were then linked to pCR status. Correlations between immune contexture and pCR for each study were interpreted using statistical testing. Meta-analysis by a logistic regression model was conducted on studies which passed assumptions to identify CIBERSORT immune subsets robust to pCR. Results: CIBERSORT results showed that three studies had reduced T follicular helper cells (Tfh) (Brodsky p=0.38, CHER-LOB p=0.17, TransNOAH p=0.25) and two studies had reduced plasma cells (CHER-LOB p=0.15, Brodsky p=0.38) in the pCR group, but was not significant after multiple correction. ESTIMATE analysis showed that data from two studies had elevated immune infiltration in pCR (Brodsky p=0.19, CHER-LOB p=0.10) but was not significant. A meta-analysis of pooled data from four studies (TRIO-US B07, 03-311, TransNOAH, CHER-LOB) showed that low Tfh (p=0.053, OR=0.04, CI [0.0012-0.99]) and high memory B-cells (p=0.008, OR=2126.9, CI [8.12-7.65 × 10+5]) prior to trastuzumab treatment may be associated with a better chance of achieving pCR. Conclusion: Results from our meta-analysis proposed that memory B- and T follicular helper subsets may predict a role in achieving pCR. Incorporating studies with larger sample cohorts such as the CALGB-40601 (N=265) study can achieve statistical power of this analysis. Citation Format: Dalal AlSultan, Alex J. Eustace, Stephen F. Madden, John Crown. In-silico approaches that detect immune contexture to trastuzumab response in neo-adjuvant studies [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P5-02-10.
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Moon, Chang In, Byron Jia, and Bing Zhang. "Abstract P2-12-02: ClinicalomicsDB - Bridging the gap between clinical omics data and machine learning." Cancer Research 83, no. 5_Supplement (March 1, 2023): P2–12–02—P2–12–02. http://dx.doi.org/10.1158/1538-7445.sabcs22-p2-12-02.
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Abstract BACKGROUND: Clinical trials are controlled patient studies aiming to objectively assess the effectiveness of treatment interventions. However, the average effectiveness observed at the group level does not directly apply to individual patients. Cancer clinical trials that include molecular profiling on the baseline tumor samples enable the discovery of treatment response-associated molecular features and the development of prediction models that help discriminate responders from non-responders in each treatment arm. Despite potential opportunities, there are many challenges associated with the predictive modeling of such data, as exemplified by the small sample size and large feature space. Advances in machine learning and artificial intelligence (AI) may provide new solutions to address these challenges. However, for machine learning and AI to have an impact, data needs to be carefully curated, high-quality, standardized, and easily accessible and understood by data scientists, who may not have the domain knowledge. METHODS: Here, we created a python package “ClinicalOmicsDB” to address the challenges of data accessibility and promote development and application of machine learning methods to omics data from clinical trial samples with treatment response information. The package makes data readily analyzable by data scientists so that they can develop, utilize, and optimize their algorithms for predicting treatment responses and discovering novel biomarkers. To promote a two-way dialogue, we have also developed several Jupyter Notebook tutorials for biologists or clinicians who wish to gain expertise in machine learning. Omics data from clinical studies are downloaded from Gene Expression Omnibus (GEO) and responses were determined based on clinical trial primary endpoints. Currently, the package has datasets from 22 breast cancer clinical trials, including a total of 5050 patients (Table 1). It will be continuously expanded to include additional trials for breast cancer and other cancer types. RESULTS: To evaluate package utility, we built machine learning models to predict neoadjuvant chemotherapy with four cycles of 5-fluorouracil/epirubicin/cyclophosphamide (FEC) followed by four cycles of docetaxel/capecitabine on US Oncology clinical trial 02-103 [GSE42822]. The best performing model was the Random Forest Classifier model, which had an AUC of 0.817. To determine the generalizability of machine learning models established from the package, we trained a Random Forest Classifier model using the GSE25055 breast cancer dataset and apply the model to a different breast cancer dataset, GSE20194, which yielded an AUC of 0.648. These results suggest utilizing machine learning on clinical omics datasets can provide predictive and generalizable models that could be implemented in clinical settings for future breast cancer patients. CONCLUSION: We are expanding the database for data scientists, biologists, and clinicians to practice novel biotechnology-derived therapies to facilitate the implementation of precision medicine approaches for future patients. As more people add new data to the package, we will work towards improving pharmaceutical and private companies’ clinical trial data sharing policies and practices to promote data sharing. Table 1. Available breast cancer datasets in ClinicalOmicsDB The current database has 22 breast cancer clinical trials with 5050 total patients. Therapy shows various cytotoxic and/or targeted treatments utilized in a clinical trial. The database will be continuously expanded to include additional trials for breast cancer and other cancer types. Citation Format: Chang In Moon, Byron Jia, Bing Zhang. ClinicalomicsDB - Bridging the gap between clinical omics data and machine learning [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P2-12-02.
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Artalejo, J. R., and O. Hernández-Lerma. "Performance analysis and optimal control of the Geo/Geo/c queue." Performance Evaluation 52, no. 1 (March 2003): 15–39. http://dx.doi.org/10.1016/s0166-5316(02)00161-x.
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Marcucci, Guido, M. D. Radmacher, A. S. Ruppert, K. Mrózek, J. E. Kolitz, S. P. Whitman, C. G. Edwards, et al. "Independent Validation of Prognostic Relevance of a Previously Reported Gene-Expression Signature in Acute Myeloid Leukemia (AML) with Normal Cytogenetics (NC): A Cancer and Leukemia Group B (CALGB) Study." Blood 106, no. 11 (November 16, 2005): 755. http://dx.doi.org/10.1182/blood.v106.11.755.755.
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Abstract The heterogeneous clinical outcome of NC AML patients (pts), who constitute about 45% of AML pts and are assigned to an intermediate-risk category, likely reflects a biologic diversity. Although mutations in FLT3, MLL, CEBPA and NPM genes and overexpression of BAALC at diagnosis can stratify prognostically NC AML, novel approaches may improve the predictive value of these markers. cDNA microarrays were used recently to gain insight into the biologic and clinical heterogeneity of NC AML. Bullinger et al. (NEJM2004;350:1605) reported a set of 133 genes represented by 149 cDNAs (Suppl. Table 6, www.ncbi.nlm.nih.gov/geo/, accession #GSE425) that separated NC AML into 2 cluster-based groups with significant differences in overall survival (OS) (Bullinger et al. Fig. 4D), albeit the number of pts analyzed was small. Hence, we sought to validate this signature in a larger, independent set of adults (n=64), <60 years, with primary NC AML, treated on CALGB 9621. Pretreatment samples were analyzed using Affymetrix U133 plus 2.0 GeneChips (Affymetrix, Santa Clara, CA). Normalization to a baseline array with median overall brightness and probe-set level expression computation were performed with dChip version 1.3. The log (base 2) of expression values were exported to BRB-ArrayTools v3.2.3 for analysis. Of the 133 genes from Bullinger et al., 81, represented by 157 probe sets, were on the Affymetrix chip and were expressed in ≥ 25% of our specimens. Hierarchical clustering, using the 157 probe sets, resulted in cluster I, corresponding to the poor-, and cluster II, corresponding to the good-outcome group in Bullinger et al. With a 4.7-year median follow-up, cluster I pts had lower estimated 5-year DFS (24% vs. 60%; P=.001; Fig. 1A) and OS (28% vs. 64%; P=.001; Fig. 1B) rates than cluster II pts. The 2 groups had similar complete remission rates (81% vs. 89%). With regard to pretreatment features, cluster I pts were younger (P=.06), had lower % skin infiltrates (P=.03), higher % marrow blasts (P=.06), different distribution of FAB subtypes (P=.04) with a high % M4, and higher incidence (67% vs. 12%) of FLT3 internal tandem duplication (ITD) (P<.001). A multivariable model including gene-expression cluster membership, FLT3 ITD status by Genescan analysis, and their interaction was fit to determine if the gene-expression signature added any information once accounting for FLT3 ITD status. A significant interaction of the gene-expression signature and FLT3 status was observed for DFS (P=.009) and OS (P=.01), where the gene-expression signature predicted DFS (P=.02) and OS (P=.02) only in pts with wild-type (wt) FLT3 but not in those with FLT3 ITD, who had adverse outcome irrespective of the gene-expression signature. Cluster I pts with wtFLT3 had >3x the risk of relapse and death than the corresponding cluster II pts. In conclusion, we independently validated for the first time the prognostic value of a gene-expression signature in NC AML. This expression profiling appears particularly useful in predicting outcome of pts lacking the prognostically adverse FLT3 ITD. Fig. 1A, Fig. 1B Fig. 1A, Fig. 1B.
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Durr, P. A., and A. E. A. Froggatt. "How best to geo-reference farms?" Preventive Veterinary Medicine 56, no. 1 (November 2002): 51–62. http://dx.doi.org/10.1016/s0167-5877(02)00123-x.
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Seitz, Robert S., Tyler J. Nielsen, Brian Ring, Catherine T. Cronister, Matthew G. Varga, Daniel Bailey, Matteo Dugo, Giampaolo Bianchini, and Douglas T. Ross. "Abstract P5-02-26: The 27-gene IO score is associated with pathologic complete response (pCR) in HR+/HER2- breast cancer patients treated with pembrolizumab in the I-SPY2 Trial." Cancer Research 83, no. 5_Supplement (March 1, 2023): P5–02–26—P5–02–26. http://dx.doi.org/10.1158/1538-7445.sabcs22-p5-02-26.
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Abstract Introduction Immune checkpoint inhibitor (ICI) therapy is efficacious for many tumor types and has been approved in both early-stage and metastatic triple negative breast cancer. However, no such approval exists for hormone receptor positive (HR+) breast cancer (BC) which typically has a lower TMB, lower PD-L1 expression, and lower numbers of tumor infiltrating lymphocytes, leaving an unmet need for a biomarker to determine ICI response. The 27-gene IO score has previously demonstrated association with response to ICI therapy in NSCLC, mUC, and TNBC but has not yet tested a cohort of HR+/HER2- breast cancer. Methods To determine the ability of the IO score to identify responders with HR+/HER- BC clinical and expression data from publicly available RNA expression data from the I-SPY2 trial were retrieved from Gene Expression Omnibus (GEO) under accession number GSE194040. Expression data were normalized, combined, batch corrected, and log-transformed by the submitting institution. This left an expression matrix of 19134 genes and 988 samples for analysis as well as corresponding clinical data. Within this sample set, 40 patients were HR+/HER- and received pembrolizumab and cytotoxic chemotherapy while 64 patients comprised the control arm (chemotherapy only). Results In the I-SPY2 trial, within the 40 patients who received pembrolizumab, 12 patients achieved pCR (30%) and 19 patients were IO+ (47.5%). Of the 12 pCR patients, 9 were IO+ (75%) and of the 28 RD patients, 18 were IO- (64%), resulting in an odds ratio of 5.4 (95% CI 1.2-24.7, p< 0.03). Considering the 64 HR+/HER- patients in the paclitaxel arm, 10 achieved pCR (15.6%) and 21 were IO+ (32.8%). Of the 10 pCR patients, 5 were IO+ (50%) and of the 54 RD patients, 38 were IO- (70%), resulting in an odds ratio of 2.4 (95% CI 0.6-9.3, p>0.2). Conclusions Despite a generally low inflammatory tumor microenvironment characteristic of the HR+ BC phenotype, the IO+ group was 3x more likely to achieve pCR with the addition of pembrolizumab to chemotherapy. These data extend on previous findings in neoadjuvant treatment of TNBC and advanced colon cancer that IO score is associated with response only in the presence of ICI therapy, not in the presence of chemotherapy alone. This is the first study to demonstrate the association of IO score with pathologic complete response to immune therapy in hormone receptor positive BC. Citation Format: Robert S. Seitz, Tyler J. Nielsen, Brian Ring, Catherine T. Cronister, Matthew G. Varga, Daniel Bailey, Matteo Dugo, Giampaolo Bianchini, Douglas T. Ross. The 27-gene IO score is associated with pathologic complete response (pCR) in HR+/HER2- breast cancer patients treated with pembrolizumab in the I-SPY2 Trial. [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P5-02-26.
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Patil, A. A., A. P. Annachhatre, and N. K. Tripathi. "Comparison of conventional and geo-spatial EIA." Environmental Impact Assessment Review 22, no. 4 (August 2002): 361–75. http://dx.doi.org/10.1016/s0195-9255(02)00013-6.
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Boselli, Chris, Jason Danis, Sandra McQueen, Alex Breger, Tao Jiang, Douglas Looze, and Daiheng Ni. "Geo-fencing to secure airport perimeter against sUAS." International Journal of Intelligent Unmanned Systems 5, no. 4 (October 9, 2017): 102–16. http://dx.doi.org/10.1108/ijius-02-2017-0002.
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Purpose Small unmanned aircraft systems (sUAS) are becoming increasingly popular among hobbyists, and with this popularity there comes the risk of runway incursion between a commercial aircraft and sUAS around airports. To keep airports safe and secure, the purpose of this paper is to propose a module, called the Airport Secure Perimeter Control System, that can be attached to every hobbyist’s sUAS for the purpose of notification and prevention. Design/methodology/approach Upon startup, the module connects to a database containing the central coordinates of every airport in the USA. A five-mile critical radius plus an additional one-mile buffer region is established around each point. The buffer region is created in order to inform the user that he/she is approaching a safe airspace and needs to take corrective action. Once the five-mile zone has been breached, autopilot software takes over the manual controls, and the sUAS is landed in a controlled manner, while the user still has lateral control of the vehicle in order to avoid any potential hazards below it. Then, both operator and airport receive messages about the event. Findings To demonstrate the proposed design, a prototype was developed that successfully implemented this system, and was formally tested within a controlled environment. Originality/value This solution would drastically reduce the security threat of sUAS breaching the critical regions surrounding airports, and its implementation is relatively simple.
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Duret, François. "Staging or upper stage reignition for GEO missions." Acta Astronautica 51, no. 1-9 (July 2002): 33–38. http://dx.doi.org/10.1016/s0094-5765(02)00086-3.
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Mori, Hirotoshi, Hiroshi Miki, and Nobuyuki Tsuneoka. "The geo-tube method for dioxin-contaminated soil." Geotextiles and Geomembranes 20, no. 5 (October 2002): 281–88. http://dx.doi.org/10.1016/s0266-1144(02)00027-4.
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Zahid, Anwar, Sumaira, and Riaz Sadia. "Geo-Strategic Significance of Kandahar for Mughal Empire." Global Social Sciences Review I, no. II (December 30, 2016): 18–29. http://dx.doi.org/10.31703/gssr.2016(i-ii).02.
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Kandahar is one of the most significant and important region of Afghanistan. It had been ruled by the great dynasties like Greece, Muryans, Kushans, Hindu Shahis, Mongols and the Mughals etc. Because of its significant location, Kandahar remained the bone of contention between different Empires and dynasties. When the Mughal occupied India, it became necessary for them to make a strong hold on Kandahar because of its strategic location that connects Persia with India. Kandahar was a gateway to India from Persia and for the safety of India and Kabul the Mughals were struggling to have strong control over the area. It connects South Asian subcontinent with Central Asia, Middle East and the Persian Gulf. On the other side Persia considered Kandahar as her integral part particularly from the reign of Shah Tahmasp and always remained busy in taking its control from the Mughals. It was necessary for them to take control of Kandahar for accomplishing the Safavid expansion policy. Thus, Kandahar remained a sandwich between two great Empires.
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Susanti, D. "The Impact of Rendezvous Proximity Operation Mission on Space Debris Toward Sustainable Space Activities." Bulletin of Science and Practice 7, no. 3 (March 15, 2021): 17–32. http://dx.doi.org/10.33619/2414-2948/64/02.
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Abstract. In the last thirty years, the encounter and approach of Rendezvous Proximity Operations (RPO) of human made space objects have developed. This development indicated by the developments in field of technology. The focus of this study is regarding RPO as a mission that has potential to increase the amount of space debris. This study aims to analyze the RPO activity as a potential hazardous mission in increasing the space debris population. Moreover, this research aims to analyze RPO activity as a potentially vulnerable mission to increase the space debris population. In this study, the method was carried out descriptively, by exploring data and information about RPO. The results of this study indicated that RPO activity still limited to LEO due to the high difficulty level for the GEO orbit. The results of this study indicate that RPO activity is still limited to LEO due to the high difficulty level for the GEO orbit. This is actually because in LEO orbit have more space debris (75%) than GEO orbit and it has a higher risk of falling to Earth. Based on the results obtained, it can be concluded that RPO activities are double-edged and therefore greater supervision needs to be carried out especially to safeguard Indonesia’s interests in space.
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Serenko, Irina. "CHANGING GEO-POLITICAL DYNAMICS AND RUSSIA-PAKISTAN RELATIONS." Eastern Analytics, no. 2 (2020): 143–51. http://dx.doi.org/10.31696/2227-5568-2020-02-143-151.
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The article examines the common tendency of the regional integration in the foreign policies of Russia and Pakistan marked by the enhancement of their bilateral relations in the rapidly changing global and regional environment. Their cooperation has been gradually reaching a new level of mutually beneficial partnership as a reflection of Moscow and Islamabad recent involvement in the undertaken formation of the joint economic and security structure of the emerging Greater Eurasia.
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Priscoli, Francesco Delli, and Antonio Pietrabissa. "Closed-loop congestion control in a GEO satellite system." Control Engineering Practice 11, no. 4 (April 2003): 387–401. http://dx.doi.org/10.1016/s0967-0661(02)00115-6.
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Wang, C., S. X. Zhang, S. Song, J. Qiao, R. Zhao, M. J. Chang, Y. Zhang, G. Y. Liu, P. F. He, and X. Li. "POS0743 GENE EXPRESSION MICROARRAY IN LUPUS NEPHRITIS BY BIOINFORMATIC ANALYSIS." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 623.1–623. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2062.
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Background:Nephritis is one of the predominant causes of morbidity and mortality in patients with lupus1 2.The lack of understanding regarding the molecular mechanisms of lupus nephritis(LN) hinders the development of specific targeted therapy for this progressive disease3.Objectives:In this study, we use bioinformatics method to analyze the genes involved in regulating the potential pathogenesis of LN.Methods:The expression profile of LN(GSE104948 and GSE32591) was obtained from the GEO database.GSE104948 was a memory chip, which included 32 LN glomerular biopsy tissues and 3 glomerular tissues from living donors.GSE32591 dataset included 32 LN glomerular biopsy tissues and 15 glomerular tissues from living donors. The Oligo package was used to process the data to obtain the expression matrix files of all the related genes.P<0.05 and |log2(FC)|>2 were setted as cut-off criteria for the DEGs.Ggplot2, heatmap packages were used to DEGs visualization. Metascape online tool was used to annotating DEGs for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis performed.We used STRING online database to construct protein-protein interaction (PPI) network. Hub genes were identified by Cytoscape.Results:In differential expression analysis,357 DEGs were identified,including 248 up-regulated genes and 109 down-regulated genes (Figure 1A,B).GO enrichment showed that these DEGs were primarily enriched in biological pathways, cell localization and molecular function and revealed that LN-related genes mainly involved in immune response.KEGG pathway annotation enrichment analysis revealed these DEGs were closely associated with Staphylococcus aureus infection,Complement and coagulation cascades (Figure 1D). Fourteen hub genes(IFT3,IRF7,OAS3,GBP2,RSAD2,MX1,IFIT2,IFI6,MX2,ISF15,IFIT1,QAS2,OASL,OAS1) were identified from PPI network (Figure 1C,E).Conclusion:Illuminating the molecular mechanisms of LN was help for deep understanding of LN.References:[1]Song J, Zhao L, Li Y. Comprehensive bioinformatics analysis of mRNA expression profiles and identification of a miRNA-mRNA network associated with lupus nephritis. Lupus 2020;29(8):854-61. doi: 10.1177/0961203320925155 [published Online First: 2020/05/22].[2]Yao F, Sun L, Fang W, et al. HsamiR3715p inhibits human mesangial cell proliferation and promotes apoptosis in lupus nephritis by directly targeting hypoxiainducible factor 1alpha. Mol Med Rep 2016;14(6):5693-98. doi: 10.3892/mmr.2016.5939 [published Online First: 2016/11/24].[3]Dall’Era M. Treatment of lupus nephritis: current paradigms and emerging strategies. Curr Opin Rheumatol 2017;29(3):241-47. doi: 10.1097/BOR.0000000000000381 [published Online First: 2017/02/17].Acknowledgements:This project was supported by National Science Foundation of China (82001740), Open Fund from the Key Laboratory of Cellular Physiology (Shanxi Medical University) (KLCP2019) and Innovation Plan for Postgraduate Education in Shanxi Province (2020BY078).Disclosure of Interests:None declared
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LI, Y., S. X. Zhang, J. Qiao, Q. Wang, S. Song, R. Zhao, Y. Zhang, et al. "POS1211 IDENTIFICATION OF COMMON FUNCTIONAL PATHWAYS IN PATIENTS WITH LUPUS AND COVID-19 BY TIME-SERIES ANALYSIS." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 888.2–889. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2384.
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Background:Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by abnormal activity of the immune system, producing the autoantibodies directed against nuclear and cytoplasmic antigens1. Infection is known as one of the common trigger factors for SLE. Coronavirus disease in 2019 (COVID-19), a severe acute respiratory syndrome, is now spreading rapidly throughout the world2.Though previous studies have addressed the susceptibility of lupus patients to the virus but how patients with SLE deal with COVID-19 is unclear up until now.Objectives:To clarify the common pathogenesis of SLE and COVID-19, and find the appropriate treatment for Lupus and prevent COVID-19.Methods:The transcription profile of SLE (GSE38351) and COVID-19 (GSE161778) were obtained from the Gene Expression Omnibus database (GEO). R package was used to find differentially expressed genes (DEGs) between lupus patients and HCs. After background adjustment and other pre-procession, DEGs were extracted from the peripheral blood of patients with COVID-19 at three different disease progression(moderate, severe and remission status). The Short Time-series Expression Miner (STEM) was used to cluster and compare average DEGs with coherent changes. The different expression patterns of time-series genes (TSGs) were also compared among these patients. GO and KEGG pathway enrichment analysis of TSGs and DEGs were performed by Metascape.Results:Compared with HC, patients with SLE expressed 977 DEGs, which were mainly associated with defense response to virus, Epstein-Barr virus infection and response to interferon-γ(INF-γ) (Figure 1a). As for COVID-19 patients, there were 1584 DEGs obtained when compared with those of HCs (P < 0.05) (Figure 1b). Gene landscapes suggested the signatures of COVID-19 patients gradually changed during the disease progression, and gradually converge to HCs signatures. Time-series genes in the three stage of disease had different expression patterns and functions. A total of 959 TSGs in profile 3 showed a stable-stable-decreasing expression trend and significantly associated with INF signaling pathway (Figure 1c,1d). Interestingly, patients with SLE and COVID-19 shared common pathways such as INF-γ related functional pathway.Conclusion:INF-γ is an important common node of SLE and COVID-19. Controlling the production of INF-γ not only has therapeutic effect on SLE patients, but also may prevent COVID-19.References:[1]Tsokos GC. Systemic lupus erythematosus. N Engl J Med 2011;365(22):2110-21. doi: 10.1056/NEJMra1100359 [published Online First: 2011/12/02][2]Wan DY, Luo XY, Dong W, et al. Current practice and potential strategy in diagnosing COVID-19. Eur Rev Med Pharmacol Sci 2020;24(8):4548-53. doi: 10.26355/eurrev_202004_21039 [published Online First: 2020/05/07]Acknowledgements:This project was supported by National Science Foundation of China (82001740), Open Fund from the Key Laboratory of Cellular Physiology (Shanxi Medical University) (KLCP2019) and Innovation Plan for Postgraduate Education in Shanxi Province (2020BY078).Disclosure of Interests:None declared.
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Косьянчук, Нина. "ВЛИЯНИЕ ОТХОДОВ ЖИВОТНОВОДСТВА НА ОКРУЖАЮЩУЮ СРЕДУ." Modern engineering and innovative technologies, no. 08-02 (June 29, 2018): 4–7. http://dx.doi.org/10.30890/2567-5273.2019-08-02-008.
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Livestock facilities pose an environmental threat to the environment, mainly due to the need to recycle waste, that if poorly managed, can get into the geo -, hydro - and air environment. To solve environmental problems, it is necessary to introduce low-w
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Lin, Yu-Hsien, and Hsin-Chung Chen. "Critical factors for enhancing green service innovation." Journal of Hospitality and Tourism Technology 9, no. 2 (June 11, 2018): 188–203. http://dx.doi.org/10.1108/jhtt-02-2017-0014.
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PurposeThe purpose of this study is to examine the influences of green entrepreneurial orientation (GEO) and green relationship quality (GRQ) on green service innovation (GSI).Design/methodology/approachThe authors mailed 1,898 questionnaires to the sampled companies. Ultimately, 207 companies participated in the authors’ study. This resulted in a valid sample of 542 hotel managers.FindingsThe research results indicate that GEO improves GRQ and GSI. Furthermore, GRQ positively affects GSI and mediates the relationship between GEO and GSI.Research limitations/implicationsThe authors’ study enhances the quality of nature and highlights the mediation role of GRQ.Practical implicationsFirms can create and establish GRQ to enhance their GSI.Social implicationsThe authors’ study shows that environmentally friendly firms can enhance natural locations and conditions of natural resources.Originality/valueThis study aims to develop a context-specific model of GEO for hospitality managers.研究目的本论文旨在研究绿色创业倾向和绿色关系质量对于绿色服务创新的影响。研究设计/方法/途径本论文采用邮寄问卷采样形式, 向采样公司共寄出1898份问卷。最终, 207家公司参与本研究项目。有效样本数量为542份来自酒店经理人的问卷。研究结果绿色创业倾向对于绿色关系质量和绿色服务创新有着促进作用。此外, 绿色关系质量积极地影响绿色服务创新, 并且对于绿色创业倾向和绿色服务创新有着中间变量的作用。研究理论限制/意义本论文对提高自然质量有着促进作用, 并且着重说明了绿色关系质量的中间调解作用。研究实践意义公司能够通过创造和建立绿色关系质量的手段来提高他们的绿色服务创新。研究原创性/价值本论文以特定背景为基础, 建立了一个针对酒店经理人的绿色创业倾向的模型.
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Rajamanickam, N., R. Shanmugavel, N. Prithivikumaran, T. Palaniselvam, and S. P. Bagare. "Transition probability parameters for certain band systems of astrophysical molecule GeO." Astroparticle Physics 19, no. 2 (May 2003): 299–302. http://dx.doi.org/10.1016/s0927-6505(02)00220-7.
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Vinokurov, V. "Reasons, background and stages of the second world war." Diplomatic Service, no. 4 (August 1, 2020): 12–17. http://dx.doi.org/10.33920/vne-01-2004-02.
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The article considers the geo-historical, socio-economic, demographic, military-political and other conditions of the second world war, as well as its stages, from the perspective of the requirements of objective history. Special attention is drawn to those international events and facts that became the trigger for the appearance of casus belli (the reason for war).
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Khamaisi, Rassem. "Shared space, separate geo-politically: Al-Quds Jerusalem capital for two states." Geoforum 33, no. 3 (August 2002): 278–83. http://dx.doi.org/10.1016/s0016-7185(02)00012-x.
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Ferrari, Giovanni M., Franco G. Bo, and Marcel Babin. "Geo-chemical and optical characterizations of suspended matter in European coastal waters." Estuarine, Coastal and Shelf Science 57, no. 1-2 (May 2003): 17–24. http://dx.doi.org/10.1016/s0272-7714(02)00314-1.
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Draim, John E., Richard Inciardi, Ron Proulx, Paul J. Cefola, David Carter, and Duane E. Larsen. "Beyond GEO — using elliptical orbit constellations to multiply the space real estate." Acta Astronautica 51, no. 1-9 (July 2002): 467–89. http://dx.doi.org/10.1016/s0094-5765(02)00036-x.
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Conti, Pier Luigi. "Bootstrap approximations for Bayesian analysis of Geo/G/1 discrete-time queueing models." Journal of Statistical Planning and Inference 120, no. 1-2 (February 2004): 65–84. http://dx.doi.org/10.1016/s0378-3758(02)00499-8.
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Lecluze, Estelle, Antoine D. Rolland, Panagiotis Filis, Bertrand Evrard, Sabrina Leverrier-Penna, Millissia Ben Maamar, Isabelle Coiffec, et al. "Dynamics of the transcriptional landscape during human fetal testis and ovary development." Human Reproduction 35, no. 5 (May 1, 2020): 1099–119. http://dx.doi.org/10.1093/humrep/deaa041.
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Abstract STUDY QUESTION Which transcriptional program triggers sex differentiation in bipotential gonads and downstream cellular events governing fetal testis and ovary development in humans? SUMMARY ANSWER The characterization of a dynamically regulated protein-coding and non-coding transcriptional landscape in developing human gonads of both sexes highlights a large number of potential key regulators that show an early sexually dimorphic expression pattern. WHAT IS KNOWN ALREADY Gonadal sex differentiation is orchestrated by a sexually dimorphic gene expression program in XX and XY developing fetal gonads. A comprehensive characterization of its non-coding counterpart offers promising perspectives for deciphering the molecular events underpinning gonad development and for a complete understanding of the etiology of disorders of sex development in humans. STUDY DESIGN, SIZE, DURATION To further investigate the protein-coding and non-coding transcriptional landscape during gonad differentiation, we used RNA-sequencing (RNA-seq) and characterized the RNA content of human fetal testis (N = 24) and ovaries (N = 24) from 6 to 17 postconceptional week (PCW), a key period in sex determination and gonad development. PARTICIPANTS/MATERIALS, SETTING, METHODS First trimester fetuses (6–12 PCW) and second trimester fetuses (13–14 and 17 PCW) were obtained from legally induced normally progressing terminations of pregnancy. Total RNA was extracted from whole human fetal gonads and sequenced as paired-end 2 × 50 base reads. Resulting sequences were mapped to the human genome, allowing for the assembly and quantification of corresponding transcripts. MAIN RESULTS AND THE ROLE OF CHANCE This RNA-seq analysis of human fetal testes and ovaries at seven key developmental stages led to the reconstruction of 22 080 transcripts differentially expressed during testicular and/or ovarian development. In addition to 8935 transcripts displaying sex-independent differential expression during gonad development, the comparison of testes and ovaries enabled the discrimination of 13 145 transcripts that show a sexually dimorphic expression profile. The latter include 1479 transcripts differentially expressed as early as 6 PCW, including 39 transcription factors, 40 long non-coding RNAs and 20 novel genes. Despite the use of stringent filtration criteria (expression cut-off of at least 1 fragment per kilobase of exon model per million reads mapped, fold change of at least 2 and false discovery rate adjusted P values of less than <1%), the possibility of assembly artifacts and of false-positive differentially expressed transcripts cannot be fully ruled out. LARGE-SCALE DATA Raw data files (fastq) and a searchable table (.xlss) containing information on genomic features and expression data for all refined transcripts have been submitted to the NCBI GEO under accession number GSE116278. LIMITATIONS, REASONS FOR CAUTION The intrinsic nature of this bulk analysis, i.e. the sequencing of transcripts from whole gonads, does not allow direct identification of the cellular origin(s) of the transcripts characterized. Potential cellular dilution effects (e.g. as a result of distinct proliferation rates in XX and XY gonads) may account for a few of the expression profiles identified as being sexually dimorphic. Finally, transcriptome alterations that would result from exposure to pre-abortive drugs cannot be completely excluded. Although we demonstrated the high quality of the sorted cell populations used for experimental validations using quantitative RT-PCR, it cannot be totally excluded that some germline expression may correspond to cell contamination by, for example, macrophages. WIDER IMPLICATIONS OF THE FINDINGS For the first time, this study has led to the identification of 1000 protein-coding and non-coding candidate genes showing an early, sexually dimorphic, expression pattern that have not previously been associated with sex differentiation. Collectively, these results increase our understanding of gonad development in humans, and contribute significantly to the identification of new candidate genes involved in fetal gonad differentiation. The results also provide a unique resource that may improve our understanding of the fetal origin of testicular and ovarian dysgenesis syndromes, including cryptorchidism and testicular cancers. STUDY FUNDING/COMPETING INTEREST(S) This work was supported by the French National Institute of Health and Medical Research (Inserm), the University of Rennes 1, the French School of Public Health (EHESP), the Swiss National Science Foundation [SNF n° CRS115_171007 to B.J.], the French National Research Agency [ANR n° 16-CE14-0017-02 and n° 18-CE14-0038-02 to F.C.], the Medical Research Council [MR/L010011/1 to P.A.F.] and the European Community’s Seventh Framework Programme (FP7/2007-2013) [under grant agreement no 212885 to P.A.F.] and from the European Union’s Horizon 2020 Research and Innovation Programme [under grant agreement no 825100 to P.A.F. and S.M.G.]. There are no competing interests related to this study.
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Kovalchuk, Svitlana. "Applying the Concept of Public Utility in Petrol Stations Placing: Geo-Marketing Approach." Economic journal of Lesia Ukrainka Eastern European National University 6, no. 2 (2016): 36–41. http://dx.doi.org/10.29038/2411-4014-2016-02-36-41.
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Boehmer-Christiansen, Sonja. "The geo-politics of sustainable development: bureaucracies and politicians in search of the holy grail." Geoforum 33, no. 3 (August 2002): 351–65. http://dx.doi.org/10.1016/s0016-7185(02)00018-0.
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van Leeuwen, Willem J. D., and Jean-Louis Roujean. "Land surface albedo from the synergistic use of polar (EPS) and geo-stationary (MSG) observing systems." Remote Sensing of Environment 81, no. 2-3 (August 2002): 273–89. http://dx.doi.org/10.1016/s0034-4257(02)00005-6.
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Smith, A. "Imagining geographies of the ‘new Europe’: geo-economic power and the new European architecture of integration." Political Geography 21, no. 5 (June 2002): 647–70. http://dx.doi.org/10.1016/s0962-6298(02)00011-2.
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