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Journal articles on the topic "004.852, 004.023"
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Arnaut, Oleg, Ion Grabovschi, Serghei Sandru, Gheorghe Rojnoveanu, and Ruslan Baltaga. "Indirect lung injury predictive model in experimental trauma." Moldovan Medical Journal 64, no. 2 (May 2021): 21–25. http://dx.doi.org/10.52418/moldovan-med-j.64-2.21.04.
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Background: Trauma remains a medical-social problem, still having high lethality rate. Indirect lung injury (ILI) occurs in trauma due to systemic neutrophils activation and proteases release into primarily intact tissues. There are no data in the literature regarding ILI predictive models in trauma. Material and methods: In the experimental study (19 traumatized male rabbits), the proteases, antiproteases and the pulmonary morphological changes, assessed according to the SAMCRS score (Semiquantitative Reflected Qualitative Changes Assessment Scale) were followed. There were used two statistical instruments – correlational analysis and multivariate linear regression. Results: Initially, a correlational analysis between the values of the SAMCRS score and the proteases/ anti proteases was performed. The null hypothesis was rejected (F = 7.017, p = .002). The correlation coefficient of the predicted results and the real values of SAMCRSlungs was .854, the determination coefficient being .626. The final model included the following parameters: constant (B = 9.427; 95% CI 7.341, 11.513; p <.001); α2-macroglobulin0 (B = -4.053; 95% Cl -6.350, -1.757; p = .002); AEAMP0 (B = .002; 95% CI .000, .004; p = .075); AEAMP24 (B = -. 006; 95% CI -.010, -.002; p = .003); AECG2 (B = .081; 95% CI .040, .122; p = .001); AEE0 (B = -. 026; 95% CI -.040, -.011; p = .002). Conclusions: In this research, a predictive model for indirect lung injury in experimental trauma was developed, the predictors being some elements of the proteases/antiproteases system. This, in turn, allows the hypotheses emission regarding the pathophysiology, prophylaxis and treatment of ILI.
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Rumalla, Kavelin, Chester K. Yarbrough, Andrew J. Pugely, and Ian G. Dorward. "Spinal Fusion for Pediatric Spondylolisthesis: National Trends, Complications, and Short-Term Outcomes." Neurosurgery 82, no. 5 (July 7, 2017): 701–9. http://dx.doi.org/10.1093/neuros/nyx295.
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AbstractBACKGROUNDCurrent surgical management guidelines for pediatric spondylolisthesis (PS) are reliant on data from single-center cohorts.OBJECTIVETo analyze national trends and predictors of short-term outcomes in spinal fusion surgery for PS by performing a retrospective cross-sectional analysis of the Kids’ Inpatient Database (KID).METHODSThe KID (sampled every 3 yr) was queried from 2003 to 2012 to identify all cases (age 5-17) of spinal fusion for PS (n = 2646). We analyzed trends in patient characteristics, surgical management, and short-term outcomes. Both univariate and multivariable analyses were utilized.RESULTSThe 2646 spinal fusions for PS included posterior-only fusions (86.8%, PSF), anterior lumbar interbody fusions (4.8%, ALIF), and combined anterior and posterior fusions (8.4%, APLF) procedures. The utilization of APLF decreased over time (9.9%-6.4%, P = .023), whereas the number of total spinal fusions and the proportion of PSF and ALIF procedures have not changed significantly. Uptrends in Medicaid insured individuals (1.2%-18.9%), recombinant human bone morphogenetic protein-2 insertion (8.8%-16.6%), decompression (34.7%-42.8%), and mean inflation-adjusted hospital costs ($21 855-$32 085) were identified (all P < .001). In multivariable analysis, Medicaid status (odds ratio [OR] = 1.93, P = .004), teaching hospitals (OR = 1.94, P = .01), decompression (OR = 1.78, P = .004), and the APLF procedure (OR = 2.47, P = .001) increased the likelihood of complication occurrence (all P < .001).CONCLUSIONThe addition of decompression during fusion and the APLF procedure were associated with more in-hospital complications, though this may have been indicative of greater surgical complexity. The utilization of the APLF procedure has decreased significantly, while costs associated with the treatment of PS have increased over time.
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Marcucci, Guido, K. Mrózek, A. S. Ruppert, K. Maharry, J. E. Kolitz, R. J. Mayer, M. J. Pettenati, et al. "t(8;21) Acute Myeloid Leukemia (AML) Differs from inv(16) AML in Pretreatment Characteristics, Outcome and Prognostic Factors Predicting Outcome: A Cancer and Leukemia Group B (CALGB) Study." Blood 104, no. 11 (November 16, 2004): 2017. http://dx.doi.org/10.1182/blood.v104.11.2017.2017.
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Abstract Since t(8;21) and inv(16) disrupt core binding factor in AML and confer a favorable prognosis, these cytogenetic groups are often treated similarly, but hitherto have not been compared in a large study. We compared 144 adult AML patients (pts) with t(8;21) with 168 with inv(16) enrolled on the cytogenetic study CALGB 8461. t(8;21) pts were less frequently white (P=.01), had lower hemoglobin levels (P=.03), WBC (P<.001) and % blood (P<.001) and BM blasts (P=.005), and had more frequently secondary chromosome aberrations (P<.001) than inv(16) pts, who more often had extramedullary disease (P<.001). Pts were induced with cytarabine/daunorubicin (AD) or cytarabine/daunorubicin/etoposide ±PSC833(ADE±P). Complete remission (CR) was achieved by 89% of t(8;21) and 87% of inv(16) pts. Upon multivariable analysis (MVA), non-white race (P=.006), lower platelets (P=.01) and higher BM blasts (P=.004) predicted negatively for CR in t(8;21), and lower platelets (P=.009) and hepatomegaly (P=.04) in inv(16) pts. Non-whites with t(8;21) had 5.7 times the odds of not achieving CR as whites. For the entire group (median follow-up 6.4 yrs), the estimated 5-yr overall survival (OS) and cumulative incidence of relapse (CIR) were 51% and 53%, respectively. Pts with t(8;21) showed a trend for shorter OS (46% vs 54%; P=.17) but no difference in CIR compared with inv(16) pts. Upon MVA, t(8;21) pts had worse OS than inv(16) pts (HR 1.5; P=.04), once adjusting for age, platelets, and WBC. Following first relapse, the 5-yr survival of t(8;21) pts (n=58) was shorter than that of inv(16) pts (n=74) (14% vs 36%; P=.01); in an age-adjusted model, the risk of death was 1.8 times higher for t(8;21) pts (P=.005). In a subanalysis of pts <60 yrs, consolidation therapy with multi-course high-dose cytarabine (HDAC x3 or 4) significantly decreased CIR compared to single-course HDAC (x1) in t(8;21) (5-yr CIR, 35% vs 64%; P=.005) and inv(16) (5-yr CIR, 44% vs 70%; P =.03) pts. Upon MVA, consolidation with multi-course HDAC reduced CIR for both t(8;21) and inv(16), but other prognostic factors differed (see Table). For t(8;21), induction with ADE±P and higher platelets increased risk of relapse. However, relatively few pts received ADE±P so its prognostic impact requires confirmation. For inv(16), +22 and other secondary cytogenetic aberrations, and male sex were favorable prognostic factors. Multivariable analysis (MVA) for CIR in pts <60 yrs achieving CR on CALGB 8221, 8525, 9022, 9222, 9621 Variable t(8;21) HR (95% CI); P inv(16) HR (95% CI); P HR=Hazard Ratio, CI=confidence intervals —, not included in final model Consolidation:Single vs multi-course HDAC 4.5 (2.1-9.4); <.001 3.4 (1.7-6.6); <.001 Induction:ADE±P vs AD 2.6 (1.1-5.9); .02 1.4 (0.6-3.2); .41 log(platelets) 1.8 (1.2-2.9); .007 — Secondary cytogenetics — 0.2 (<0.1-0.5); .002 Male vs Female — 0.5 (0.3-0.9); .03 In summary, once pretreatment factors and therapy are considered, the outcome of t(8;21) AML appears inferior to that of inv(16). Although these data should be confirmed prospectively, our analysis suggests that future studies should report the outcomes of pts with t(8;21) and inv(16) separately, and seek to identify and target therapeutically leukemogenic mechanisms accountable for these clinical differences.
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Lim, Sung-Nam, Je-Hwan Lee, Jung-Hee Lee, Dae-Young Kim, Se-Hyung Kim, Young-Shin Lee, Young-A. Kang, et al. "Pre-Transplant Comorbidity as An Outcome Predictor in Hematopoietic Cell Transplantation for Severe Aplastic Anemia." Blood 112, no. 11 (November 16, 2008): 4295. http://dx.doi.org/10.1182/blood.v112.11.4295.4295.
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Abstract A new hematopoietic cell transplantation specific comorbidity index (HCT-CI), which was modeled to effectively capture comorbidity and predict post-transplant outcomes, has been evaluated in a cohort of patients with a variety of hematologic disorders. In this study, we applied the HCT-CI to 77 patients with severe aplastic anemia who underwent HCT at the Asan Medical Center, Seoul, Korea between February 1995 and September 2007. Pre-transplant HCT-CI score was calculated in each patient using the clinico-pathologic data, which were retrieved from Asan Medical Center Bone Marrow Transplantation Registry Database. HCT-CI score was 0 in 54 patients (70%), 1 in 16 (21%), 2 in four (5%), and 4 in one (1%). The most prevalent comorbidity captured by the HCT-CI was infection (n=11) followed by arrhythmia (n=6). During a median follow-up period of 54.4 months (range, 4.0 to 159.0 months), 19 patients died and 16 experienced primary or secondary graft failure. The 5-year probabilities of overall survival (OS) and event-free survival (EFS) were 73.4% and 63.3%, respectively. OS and EFS were significantly different according to HCT-CI score; OS 86.6% and EFS 74.3% in patients with score 0 versus 43.5% and 38.5% in those with score 1 or more (P<0.001 for OS and P=0.001 for EFS). Other significant prognostic factors for OS were age (<30 years vs. ≥30, 90.8% vs. 58.3%, P=.002), pre-transplant transfusion amount (<50 units vs. ≥50, 93.0% vs. 61.0%; P=.005) and time from diagnosis to HCT (<120 days vs. ≥120, 85.2% vs. 61.4%; P=.013), and prognostic factors for EFS were age (<30 years vs. ≥30, 81.0% vs. 48.4%, P=.003) and time from diagnosis to HCT (<120 days vs. ≥120, 77.4% vs. 48.3%; P=.007). Multivariate analysis after adjustment for other variables demonstrated that HCT-CI score (HR 10.022, P<.001 for OS; HR 4.644, P<.001 for EFS), age (HR 8.447, P=.002 for OS; HR 4.060, P=.003 for EFS), time from diagnosis to HCT (HR 5.783, P=.002 for OS; HR 3.956, P=.002 for EFS) were independently significant prognostic factors for both OS and EFS. In conclusion, our data indicate that the presence of pre-transplant comorbidity assessed by HCT-CI may predict worse outcomes after HCT in severe aplastic anemia.
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Kim, S., J. Nam, S. Park, D. Bae, C. Park, C. Cho, J. Lee, and Y. Yun. "Study of anxiety and depression in cervical cancer survivors." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): e20644-e20644. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e20644.
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e20644 Background: Cervical cancer is the second leading cause of cancer related deaths among women in Korea. However, few studies have been conducted to elucidate the psychological distress of this population. This study aimed to examine the prevalence of anxiety and depression among cervical cancer survivors, and to identify factors associated with such caseness. Methods: A total of 832 cervical cancer survivors recruited from six large hospitals in Korea completed a mailed survey, which included the Hospital Anxiety and Depression Scale (HADS), European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, and QLQ-CX24. Anxiety and depression were defined by a score of ≥ 8 on the HADS subscales. With a framework that included socio-demographic, clinical, and symptom characteristics, multivariate logistic regression models were used to identify factors associated with anxiety and depression. Results: Among cervical cancer survivors, 34.3% reported HADS-defined anxiety and 39.7% reported HADS-defined depression. Anxiety was associated with having a lower income (OR=1.95, p=.021), smoking (OR=2.42, p=.002), poor body image (OR=3.26, p<.001), peripheral neuropathy (OR=2.21, p=.002), menopausal symptoms (OR=2.02, p=.004), and sexual inactivity (OR=2.35, p=.001). Depression was associated with younger age (OR=1.75, p=.006), having a lower income (OR=2.14 p<.001), drinking (OR=1.56, p=.050), poor body image (OR=4.59, p<.001), peripheral neuropathy (OR=2.34, p<.001), and sexual inactivity (OR=2.68, p=.002). Both anxiety and depression were influenced by socio-demographic factors, health behaviors, and cervical cancer-specific symptom characteristics rather than cancer- or treatment-related factors. Conclusions: Anxiety and depression were highly prevalent among cervical cancer survivors in Korea. This examination of risk factors for anxiety and depression will be helpful for the development of clinical management strategies in cervical cancer survivors. No significant financial relationships to disclose.
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Bener, Abdulbari, Yaşar Özdenkaya, Cem Cahit Barışık, and Mustafa Öztürk. "The Impact of Metabolic Syndrome on Increased Risk of Thyroid Nodules and Size." Health Services Research and Managerial Epidemiology 5 (January 1, 2018): 233339281877551. http://dx.doi.org/10.1177/2333392818775517.
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Aim: The present research aimed to determine the relation between metabolic syndrome (MetS) and thyroid volume and nodule prevalence among Turkish population patients. Methods: This retrospective cohort study was carried on 850 patients between the ages of 20 and 65 who visited the diabetic, endocrinology, and general surgery outpatient clinics in the Mega Medipol and Medipol Hospital between January 2014 and December 2017. This study included sociodemographic information, body mass index (BMI), diabetes mellitus (DM), systolic (SBP) and diastolic (DBP) blood pressures, and clinical biochemistry results such as serum triglyceride, total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL) cholesterol, hemoglobin A1c (HbA1c), fasting blood glucose levels, thyroid-stimulating hormone (TSH), T3, T4, and other MetS parameters. Thyroid fine needle aspiration biopsy was suggested to patients whose thyroid nodules were greater than 1.00 cm. The definition and diagnostic of MetS used as proposed by the National Cholesterol Education Program—Third Adult Treatment Panel. Results: There were statistically significant differences between patients with thyroid nodules and those without regarding age, gender, BMI, physical activity, cigarette smoking, shisha smoking, family history of diabetes, hypertension, and thyroid. Meanwhile, statistically significant differences were found between with and without MetS for calcium ( P = .028), magnesium ( P < .001), potassium ( P < .001), fasting blood glucose ( P = .047), HbA1c ( P < .001), HDL ( P < .001), LDL ( P < .001), albumin ( P = .008), bilirubin ( P = .002), triglyceride ( P = .011), SBP ( P = .001) and DBP ( P = .011), TSH ( P = .005), T3 ( P < .001), and T4 ( P < .001). Furthermore, there were statistically significant differences between participants with and without thyroid nodules for calcium ( P < .001), magnesium ( P < .001), potassium ( P < .001), fasting blood glucose ( P = .010), HbA1c ( P = .019), HDL ( P < .001), LDL ( P = .012), albumin ( P = .002), bilirubin ( P < .001), triglyceride ( P < .001), SBP ( P < .001) and DBP ( P = .004), TSH ( P = .015), T3 ( P < .001), and T4 ( P < .001). Multivariate stepwise logistic regression analysis used for independent predictors for the presence of thyroid nodules which TSH ( P < .001), family history of thyroid and DM ( P < .001), age in years ( P = .025), DBP and SBP ( P < .001), BMI ( P = .014), HDL-C ( P = .034), and waist circumference (in cm; P = .044) were considered at higher risk as a predictors of thyroid with patients with MetS. Conclusion: The results of the current study confirm a strong positive association between MetS and thyroid nodules risk among patients with MetS. This study suggest that the patients with MetS can be considered as a marker to have moderately increased risk of future thyroid nodules and cancer. Meanwhile, MetS, obesity, and hyperglycemia could be a qualifiable and modifiable risk factor for thyroid nodules. The regularly glycemic control may be the most important treatment for the reduction of incidence or the prevention of thyroid.
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Heisel Kurth, Margaret A., Beverly Christie, Vicky Hanneman, Joni Osip, Kristen Appert, Christopher L. Moertel, Jan Watterson, and Maha Hag-Alshiekh. "Immune Tolerance Utilizing Intermediate Purity Factor VIII Concentrate in Hemophilia A Patients with High Factor VIII Titers." Blood 104, no. 11 (November 16, 2004): 3099. http://dx.doi.org/10.1182/blood.v104.11.3099.3099.
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Abstract Immune tolerance therapy (ITT) is a treatment that is used to eliminate factor VIII inhibitors associated with hemophilia A. However, standard ITT is not successful in approximately 20% of patients. In those who do not attain tolerance, the length of treatment with resultant cost of factor concentrate and family stress are major concerns. Utilization of intermediate purity products (IPP) has been suggested as a means to increase the success rate of ITT, shorten the duration of ITT, and decrease the quantity of factor concentrate used. We retrospectively analyzed outcomes for 8 patients who received IPP as part of an ITT regimen from 1993–2004. Four patients were switched from recombinant/monoclonal factor VIII to IPP during ITT because of poor response to initial therapy (Table 1). Four others were started on IPP at the initiation of ITT because they had already failed ITT or past history indicated a likelihood of failing standard ITT (Table 2). Tolerance was defined as having a Bethesda titer of <1 BU/ml, > 66% recovery of factor VIII, and/or a half-life of 6 hours or greater. In the first group, all four patients attained tolerance. In these patients the switch to IPP resulted in a faster drop in inhibitor titer than had been previously achieved. In the second group, one patient attained tolerance rapidly; one achieved partial tolerance and uses prophylactic IPP. A third patient is currently undergoing ITT and is responding well. The fourth patient has failed to achieve tolerance. These four patients had adverse risk factors that made them poor candidates for conventional ITT. Of the 6 patients who have achieved partial or complete tolerance, 4 have been switched back to recombinant factor VIII and have maintained tolerance. However, two patients have been maintained on IPP because attempts to switch to recombinant factor VIII resulted in a rise in their inhibitor titers. If tolerance can be achieved with IPP it can result in major cost savings for these patients. At our institution the cost of IPP is about 50–66% of the cost of recombinant factor VIII. These data are presented as further evidence that choice of factor may influence ITT success and that a subset of patients may benefit from an IPP regimen for ITT. Table 1: Recombinant/Monoclonal Use; Patients Switched to IPP ID Age at Inhibitor Dx (yrs) Peak Inhibitor (BU) Age at Start of ITT (yrs) Inhibitor at ITT Start (BU) Age at Switch to IPP (yrs) Reason for Switch Time to Tolerization 001 6.8 34 9.8 2 10.0 Poor response to ITT 12 months 002 8.2 100 11.8 1 12.1 Poor response to ITT by brother (001) 6 months 005 5.2 124 6.3 9 6.5–7.0 /8.2-present Poor response to initial therapy / inability to sustain tolerization 36 months 007 3.9 270 3.9 13 4.1 Poor response to ITT and bleeding complications 16 months Table 2: Patients Started on IPP Initially ID Age at Inhibitor Dx (yrs) Peak Inhibitor (BU) Age at Start of ITT (yrs) Inhibitor at ITT Start (BU) Time to Partial Tolerization Time to Tolerization 003 4.0 4833 21.4 6 Did not achieve NA 004 1.2 1000 12.4 10–20 29 months NA 006 1.3 600 12.4 0–1 6 months 8 months 008 0.8 277 5.8 1.1 6 months NA
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Supriyono, Supriyono, and Titiek Yulianti. "Tingkat Ketahanan 70 aksesi Plasma Nutfah Kenaf terhadap Fusarium oxysporum Schletch; Assessment of Kenaf Germplasm Against Fusarium oxysporum Schletch." Buletin Tanaman Tembakau, Serat & Minyak Industri 8, no. 2 (January 9, 2017): 65. http://dx.doi.org/10.21082/btsm.v8n2.2016.65-73.
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<p>Salah satu penyakit penting yang sangat merugikan tanaman kenaf adalah penyakit layu Fusarium yang disebabkan oleh <em>Fusarium oxysporum</em> Schlecht. Tujuan penelitian ini adalah untuk mengevaluasi tingkat ketahanan aksesi kenaf terhadap jamur <em>Fusarium oxysporum</em>. Penelitian dilakukan di laboratorium dan rumah kasa Balai Penelitian Tanaman Pemanis dan Serat, Malang menggunakan rancangan acak lengkap) yang diulang tiga kali. Dalam evaluasi ini digunakan 70 aksesi dan 1 aksesi tahan (BG-52-135) yang digunakan sebagai kontrol. Inokulasi dilakukan pada 7 hari setelah tanam (HST) menggunakan suspensi spora dengan kerapatan10<sup>5</sup>/ml sebanyak 100 ml setiap bak. Pengamatan intensitas serangan dilakukan mulai 10–40 hari setelah inokulasi (HSI) dengan interval pengamatan lima hari. Pengamatan persentase diskolorisasi batang dilakukan sekali pada 50 HSI. Hasil pengujian memperoleh 1 aksesi (FJ/017) sangat tahan dengan intensitas serangan terrendah (0,83%) dan 14 aksesi tahan dengan intensitas serangan <span style="text-decoration: underline;"><</span>10%, 28 aksesi dengan ketahanan moderat, dan 27 aksesi yang rentan terhadap infeksi <em>F. oxysporum</em>. Aksesisi FJ/017 (aksesi yang sangat tahan) dan 14 aksesi yang tahan: 1064(SUC/012), 1061(SRB/082), 1035(FJ/005), 839(PARC/2709), 955(FJ/003), 842(PARC/2712), 1095(SUC/003), 838(PARC/2708), 957(FJ/ 007), 1065(SUC/023), 1042(CHN/056), 145(BL/118), 1036(FJ/006), dan 778(PARC/2466) dapat digunakan sebagai sumber ketahanan pada perakitan varietas baru.</p><p> </p><p>One of the important disease that very detrimental to kenaf is Fusarium wilt caused by <em>Fusarium oxysporum</em> Schlecht. The purpose of this study was to evaluate the response of 70 kenaf germplasm<span style="text-decoration: line-through;">s</span> accessions against <em>F</em><em>.</em><em> oxysporum</em>. The study was conducted at the Phytopatology Laboratory and screen house of Indonesian Sweetener and Fiber Crops Research Institute, Malang using completely randomized design with three replicates. Seventy accessions and one resistant accession as control (1267 (BG-52-135) were used in this study. Inoculation of <em>Fusarium</em> was done 7 days after sowing (das) by sprinkling 100 ml of spore suspension into the soil. Observation of disease intensity started at 10–40 days after inoculation (dai) and repeated every five days. Percentage of stalk discolorization was estimated at 50 dai. The results showed that accession 1040 (FJ/017) had the lowest disease intensity (0.83%), hence was categorized as a highly resitant accession. Fourteen accessions were categorized as resistant with disease intensity below or equal to 10%; 28 accessions were moderate resistant; and 27 accessions were susceptible. FJ/017 (the highset resistant accession) and 14 resis-tant accessions (1064(SUC/012), 1061(SRB/082), 1035(FJ/005), 839(PARC/2709), 955(FJ/003), 842(PARC/ 2712), 1095(SUC/003), 838PARC/2708), 957(FJ/007), 1065(SUC/023), 1042(CHN/056), 145(BL/118), 1036 (FJ/006), dan 778(PARC/2466)) could be used as resistant genetic sources in developing new varieties.</p>
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O’Doherty, J. V., and U. Keady. "The effect of expander processing and extrusion on the nutritive value of peas for pigs." Animal Science 72, no. 1 (February 2001): 43–53. http://dx.doi.org/10.1017/s1357729800055545.
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AbstractTwo experiments were conducted to investigate the effect of expander processing of food for growing and finishing pigs. Experiment 1 examined the effects of expander processing on the nutritive value of a cereal-based diet and a pea-based diet for pigs while experiment 2 determined the effects of extrusion and expansion of the peas component of the diet on the nutritive value. In experiment 1, growth performance, carcass characteristics (no. = 12) and nutrient digestibility (no. = 4) were determined in pigs offered individually food containing a cereal diet (T1), a complete cereal diet that had been expander processed (T2), a 400 g/kg peas diet (T3) or a complete 400 g/kg peas diet that had been expander processed (T4). The expanded diets were processed at 105°C for 5 s at 35 bar pressure. In experiment 2, productive performance and nutrient digestibility were determined in pigs (no. = 12) offered individually diets including a control cereal diet (no peas) (TT1), a 400 g/kg raw peas diet (TT2), a 400 g/kg expander processed peas diet (TT3) or a 400 g/kg extruded peas diet (TT4). The pea portions of the diets were extruded at 130°C for 30 s and expanded at 130°C for 10 s at 42 bar pressure. In experiment 1, the inclusion of peas in the diet reduced (P < 0·001) the digestibility of the organic matter (OM) (0·871 v. 0·893, s.e. 0·003), protein (0·867 v. 0·907, s.e. 0·004) and energy (0·857 v. 0·880, s.e. 0·003). Expansion had no effect on the nutrient digestibility of the diets, however, it did increase (P < 0·05) the digestible energy content of the cereal diet. The inclusion of peas in the diet reduced (P < 0·05) daily gain (0·929 v. 0·999, s.e. 0·024 kg/day) and increased (P < 0·001) food conversion ratio (FCR) (2·31 v. 2·16, s.e. 0·029) from 34 kg to slaughter. Expansion had no effect on daily gain or FCR. In experiment 2, OM digestibilities of 0·891, 0·872, 0·882 and 0·885 (s.e. 0·0042) (P < 0·01), protein digestibilities of 0·905, 0·879, 0·874 and 0·877 (s.e. 0·0069) (P < 0·001) and gross energy digestibilities of 0·875, 0·861, 0·870 and 0·875 (s.e. 0·005) (P < 0·05) were recorded for TT1 to TT4 respectively. Gains (kg/day) of 0·981, 0·927, 0·940, and 1·016 (s.e. 0·036) (P < 0·05) and FCR of 2·17, 2·32, 2·28 and 2·18 (s.e. 0·037) (P < 0·05) were recorded for TT1 to TT4 respectively. In conclusion, expansion had no effect on the nutritive value of food for pigs.
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Homoud, Bareen, Alanoud Alhakami, Malak Almalki, Miselareem Shaheen, Alaa Althubaiti, Ali AlKhathaami, and Ismail A. Khatri. "The association of diabetes with ischemic stroke and transient ischemic attacks in a tertiary center in Saudi Arabia." Annals of Saudi Medicine 40, no. 6 (November 2020): 449–55. http://dx.doi.org/10.5144/0256-4947.2020.449.
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ABSTRACT BACKGROUND: Diabetes mellitus increases stroke risk 1.5 to 3 fold, particularly ischemic stroke. There is limited literature on the impact of diabetes on stroke patients in Saudi Arabia. OBJECTIVES: Determine the association of diabetes on the presentation, subtypes, in-hospital complications and outcomes of ischemic stroke and transient ischemic attacks (TIA). DESIGN: IRB approved, retrospective chart review. SETTING: Tertiary care center. PATIENTS AND METHODS: All adult patients with ischemic stroke or TIA aged 18 years or older admitted from January 2016 to December 2017 were included. MAIN OUTCOME MEASURES: Stroke severity at presentation, stroke-related complications, discharge disposition and discharge modified Rankin Scale (mRS) in relation to diabetes. SAMPLE SIZE: 802 patients. RESULTS: Among 802 cases, 584 (72.8%) had diabetes; the majority (63.1%) were males. The mean age was younger in the non-diabetic stroke group (54.6 [15.5] years vs. 63.3 [9.9], P <.001). Hypertension (83.6% vs 49.1%, P <.001), dyslipidemia (38.9% vs. 28.9%, P =.009), prior stroke (27.7% vs. 19.3% P =.014), and ischemic heart disease (20.4% vs. 7.8%, P <.001) were more common in diabetic patients whereas smoking was more common (19.3% vs. 11.1%, P =.003) in the non-diabetic patients. The commonest subtype of stroke was large artery disease followed by small vessel disease. Both were more common in diabetic vs. non-diabetic patients (55.8% vs. 44%, P =.003), and (16.6% vs. 11%, P =.05) respectively. Diabetic stroke patients were more likely to have lacunar stroke (16.4% versus 9.2%, P =.009). TIAs occurred more commonly in the non-diabetic group (26.1% vs. 13.7%, P <.001). Non-diabetic patients had a better outcome (mRS score of 0–2) at discharge (62.4% vs. 45.9%, P =.002). CONCLUSIONS: Almost three-fourth stroke patients were diabetic in our cohort. Diabetic stroke patients were older, had multiple vascular comorbid conditions, presented late to the hospital, and were likely to have more disability at the time of discharge. Large vessel atherosclerosis as well as lacunar infarctions were more common in diabetic stroke patients. LIMITATIONS: Missing data about time of presentation in few patients, missing modified Rankin Scale score at discharge. CONFLICT OF INTEREST: None.
Dissertations / Theses on the topic "004.852, 004.023"
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Torres, Castillo Alfredo Junior. "Informe sobre Expediente N° 003-2013-PI/TC, Nº 004-2013-PI/TC y Nº 023-2013-PI/TC." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2020. http://hdl.handle.net/20.500.12404/17865.
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El expediente jurídico versa sobre un tema actual, complejo y muy desafiante, cuya investigación
permitirá una visión panorámica y realista del derecho laboral peruano respecto al sector público.
De esta manera, la hipótesis del presente informe radica en que los trabajadores públicos tienen
el derecho a la negociación colectiva en materia económica, basados en un análisis de los principales instrumentos relacionados a los derechos fundamentales de la persona. La conclusión
del presente informe evidenció a raíz de una interpretación sistemática de los cuerpos jurídicos
nacionales e internacionales (entre ellos, los Tratados Internacionales de Derechos Humanos,
Convenios de la Organización Internacional de Trabajo, Comité Libertad Sindical, Comisión de
Expertos para la Aplicación de Convenios y Recomendaciones), que se debe regular a nivel legal la negociación colectiva en el sector público a través de un diálogo social que procure el respeto de otros principios constitucionales como el presupuestario.
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Vidal, Stefan Correia. "Otimização e controlo de um braço robótico com técnicas bio-inspiradas." Master's thesis, 2017. http://hdl.handle.net/10348/8152.
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Dissertação de Mestrado em Engenharia Eletrotécnica e de ComputadoresNa robótica industrial o transporte de cargas suspensas tem de ser feito com garantias de segurança da carga e do meio envolvente, o que normalmente se traduz em movimentos lentos para não haver oscilação da carga. Este trabalho tem como objetivo a implementação de algoritmos de controlo que possibilitem o transporte rápido de uma massa suspensa de um ponto para outro criando a mínima oscilação possível da massa no final do movimento. Neste trabalho foi utilizado o braço robótico UR5 da Universal Robots, ao qual foi acoplado um pêndulo na extremidade do mesmo, e foi definida uma trajetória linear a ser efetuada pela extremidade do braço de forma a poder criar as condições necessárias para o desenvolvimento do trabalho. Para diminuir a oscilação provocada pelo movimento rápido do braço robótico foi implementado um controlador Posicast que teve de ser adaptado tendo em conta a dinâmica do robô UR5. Para otimizar os parâmetros do controlador Posicast para o caso em estudo foi utilizado um algoritmo de otimização por enxame de partículas, adaptado a este problema, em conjunto com um simulador que permite prever o comportamento do braço robótico. Para validar a eficácia do algoritmo de otimização por enxame de partículas foi feito um conjunto de testes para diferentes condições de forma a poder comparar os resultados obtidos no simulador com os obtidos pelo robô e verificar se o parâmetro otimizado pelo algoritmo corresponde ao ideal a ser utilizado pelo UR5.
In industrial robotics the transport of suspended loads has to be performed with guarantees of safety for the load and the surrounding environment, which usually translates into slow movement so that there is no load oscillation. This work aim at the implementation of control algorithms that allow the rapid transport of a suspended mass from one point to another creating the minimum possible oscillation of the mass at the end of the movement. In this work the robotic arm UR5 of Universal Robots was used, to which a pendulum was attached to the tool center point (TCP), and a linear trajectory was defined to be executed by the robot arm TCP in order to create the necessary conditions to perform the work. To reduce the oscillation caused by the rapid movement of the robotic arm a Posicast controller adapted taking into account the dynamics of the robot UR5 was implemented. To optimize the Posicast controller parameters for the case under study, a particle swarm optimization algorithm, was used in conjunction with a simulator that enables predicting robotic arm behavior. To validate the effectiveness of the particle swarm optimization algorithm, a set of tests was executed for different conditions in order to compare the results obtained in the simulator with those obtained by the robot and to verify if the optimized parameter by the algorithm corresponds to the ideal one to be used by UR5.
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Ventuzelos, Maria Cândida de Sousa Moreira. "Animação sociocultural e abordagem literária da tradição: o exemplo de Miguel Torga." Master's thesis, 2014. http://hdl.handle.net/10348/3023.
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Dissertação de Mestrado em Ciências da Educação, Especialização em Animação SocioculturalA animação sociocultural ganha sentido inserida no conteúdo cultural de um grupo social, comunidade regional ou mesmo país. Com ela é possível disponibilizar modelos de perceção e de ação que marcaram o modo de interpretar o mundo e a sociedade e o modo das pessoas se relacionarem; e com esses modelos é mais fácil desenvolver o sentido crítico sobre paradigmas concetuais e sociológicos e fundamentar alterações no sentido da maior dignificação humana. A abordagem da cultura ao nível educativo, essencialmente como educação escolar e como educação não formal, tem na animação sociocultural um veículo privilegiado. Juntando essa possibilidade de dinamização à interdisciplinaridade, pode reconhecer-se de grande valor o estudo da visão cultural de um poeta como Miguel Torga. Este trabalho parte das tradições narradas e valorizadas por esse autor e procura manifestar modos de tratamento dessa forma cultural pela animação sociocultural. Mas procura também tomar consciência do modelo axiológico presente na tradição narrada sem esquecer alguma da dimensão literária que uma professora (de letras) deve trabalhar.
Sociocultural Animation makes sense when integrated in the culture of a social group, community, regional or even country. It provides models of perception and action that marked the way of interpreting the world and society and the way people relate. These models make it easier to develop a critical sense about conceptual and sociological paradigms and support changes towards greater human dignity. At educational level, essentially as part of formal and non-formal education, this cul-tural approach is a fundamental tool for socio-cultural activities. As an example of the inter-disciplinary project, this paper presents the study of the cultural vision of a poet as Miguel Torga. This paper stems from the traditions Torga valued and wrote about in his books. It intends to show how this cultural form can be approached by socio-cultural activities. It also takes on the axiological model within narratology. Besides, it takes into consideration the lit-erary dimension that a teacher must work upon.
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Teixeira, Eurídice Dalila Alves. "Os e-books como elo de ligação entre a matemática e a literatura infantil no 1º e 2º ciclos do Ensino Básico." Master's thesis, 2014. http://hdl.handle.net/10348/6861.
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Dissertação de Mestrado em Ensino do 1º e 2º Ciclos do Ensino BásicoA conexão entre a Matemática e a Literatura Infantil e a utilização do e-book como ponte entre estas duas áreas fundamentais do Ensino Básico, constitui o tema abordado ao longo do presente Relatório Final de Estágio. A Prática de Ensino Supervisionada subdividiu-se em dois Estágios: I e II. O Estágio I realizou-se no 1.º Ciclo do Ensino Básico, onde a professora cooperante tinha como metodologia a interdisciplinaridade, daí cresceu primeiro a necessidade, depois a motivação e por fim o entusiasmo, de criar um meio diferente de conexão entre as diferentes áreas curriculares. A conexão entre a Matemática e a Literatura Infantil é um tema recorrente de diversos estudos, porém a utilização do e-book como elo de ligação entre a duas e o seu aproveitamento em contexto de sala de aula, é algo ainda muito recente no nosso país, ou, pelo menos, a bibliografia encontrada, sobre a sua utilização em contexto educativo, é escassa. Neste trabalho descrevem-se algumas experiências implementadas no Estágio I, relativas à conexão entre a Matemática e a Literatura Infantil, cujo êxito motivou a escolha da parte inicial do tema deste relatório. Apresenta-se, também, como se desencadeou o aparecimento do e-book na sala de aula e todo o processo de criação, por parte dos alunos, dos livros digitais. Em virtude da falta de tempo e dos obstáculos que foram surgindo ao longo do Estágio I, foi difícil implementar o e-book como elo de ligação entre a Matemática e a Literatura Infantil. Contudo, apresentamos uma proposta de intervenção com dois conjuntos de atividades: as primeiras consistem na aplicação de histórias Infantis no processo de ensino e aprendizagem da Matemática e, as segundas, no uso do e-book como elo de ligação entre a Matemática e a Literatura Infantil. No Estágio II, realizado no 2.º Ciclo do Ensino Básico, também são apresentadas detalhadamente, propostas de atividades que futuramente pretendemos implementar neste Ciclo do Ensino Básico.
The connection between Mathematics and Children's Literature and the use of ebook as a bridge between these two key areas of basic education is the topic discussed throughout this Final Internship Report. The Supervised Teaching Practice was divided into two internship: I and II. Internship I was conducted in the 1st cycle of basic education, where the cooperating teacher had interdisciplinary as methodology, from there the need grew first, then the motivation and finally the enthusiasm of creating a different way of connection between the different curriculum areas. The connection between Mathematics and Children's Literature is a recurring theme in many studies, but the use of the e-book as a link between the two and his advantage in the context of the classroom is something still very new in our country, or at least, the bibliography found on its use in an educational context, is scarce. This paper describes some experiments implemented in Stage I, on the connection between Mathematics and Children's Literature, whose success has motivated the choice of the initial part of the matter of this report. It also shows how get triggered the emergence of the e-book in the classroom and the whole process of creation by the students of digital books. Because of lack of time and the obstacles that have arisen over Stage I, it was difficult to implement the e-book as a link between Mathematics and Children's Literature. However, we present a proposal for intervention with two sets of activities: the first consists in applying children stories in the teaching and learning process of mathematics and, second, the use of e-book as a link between Mathematics and Children's Literature. In internship II, held on the 2nd cycle of basic education are also presented detailed proposals for future activities that we intend to implement in this cycle of basic education.
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Albuquerque, José Marques. "Tradição clássica e judaico-cristã em Miguel Torga." Doctoral thesis, 2014. http://hdl.handle.net/10348/3356.
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Tese de Doutoramento em Língua e Cultura PortuguesasA cultura ocidental provém, sobretudo, de duas tradições: da judaico-cristã e da greco-latina. Os mitos, que as corporizam, são e sempre foram motivos de sedução nas sociedades e têm-se manifestado em diversas formas artísticas. A literatura não é exceção. No panorama literário português, destaque especial para o escritor que será objeto de estudo desta dissertação: Miguel Torga. Nas suas obras em geral, mas sobretudo no Diário e na poesia propriamente dita, há um fundo de referências e alusões aos mitos do mundo clássico e da tradição judaico-cristã. Aí, Torga reatualiza toda uma diversidade de mitos gregos, tirando partido do seu significado e aplicando-os quer a si mesmo quer à sua terra. Através deles, o poeta, enquanto artista, exprime os problemas que acompanham o Homem desde sempre: as angústias, as inquietações, as dúvidas, as expetativas. De igual modo, se manifesta evidente a presença sistemática de registos de carácter religioso que remetem para a tradição bíblica. O Outro Livro de Job é uma das obras de Torga mais densas, no que diz respeito à recriação desses elementos matriciais. Grande parte da sua profundidade de sentido e da beleza de expressão poética são devidos justamente ao jogo de alusões e citações que sublinham o carácter intertextual do texto. A linha de força que orienta esta investigação consiste, assim, em analisar a presença na obra de Torga de temas da tradição clássica e judaico-cristã, evidenciando o aproveitamento simbólico que faz de cada um deles.
Western Culture has stemmed mainly from two traditions: The Judeo- Christian and the Greco-Roman. The myths that embody them are and always have been reasons of seduction in societies and they have manifested themselves in different forms of art. Literature is no exception. In the Portuguese literary scene, we‟ll emphasize the writer who will be the subject of this dissertation: Miguel Torga. In his work in general, but especially in Diário and in poetry itself, there are lots of references and allusions to the myths of the classical world and to the Judeo-Christian tradition. Then Torga re-updates a whole range of Greek myths taking advantage from its meanings and applying them either to himself or to his land. Through them, the poet, as an artist, expresses the problems that accompany the man forever: anxieties, worries, doubts, expectations. Likewise it is evident the presence of systematic religious references to the biblical tradition. O Outro Livro de Job is one of the densest and profound works regarding the creation of these matrix elements. Much of its depth of meaning and beauty of poetic expression are precisely due to the play of allusions and quotations that underscore the inter textual character of the text. The power line that guides this research is therefore to analyze the presence of themes of classical and Judeo-Christian tradition in the work of Torga highlighting the symbolic use he makes of each.
Books on the topic "004.852, 004.023"
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United States. Environmental Protection Agency., ed. A PLAIN ENGLISH GUIDE TO THE EPA PART 503 BIOSOLIDS RULE... EPA/832/R-93/003... U.S. ENVIRONMENTAL PROTECTION AGENCY... SEPTEMBER 1994. [S.l: s.n., 2001.
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Analytical results and sample locality map of stream-sediment, heavy-mineral-concentrate, and rock samples from the Disaster Peak Wilderness Study Area (OR-003-153/NV-020-859), Harney and Malheur Counties, Oregon, and Humboldt County, Nevada. Denver, CO: U.S. Dept. of the Interior, Geological Survey, 1989.
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Analytical results and sample locality map of stream-sediment, heavy-mineral-concentrate, and rock samples from the Disaster Peak Wilderness Study Area (OR-003-153/NV-020-859), Harney and Malheur Counties, Oregon, and Humboldt County, Nevada. Denver, CO: U.S. Dept. of the Interior, Geological Survey, 1989.
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Конституционное (государственное) право зарубежных стран. Vol. 1, Часть общая: конституционное право, человек, общество. Москва: БЕК, 1993.
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Simão, Alessandra dos Santos, Aline Marques Marino, Ana Gabriela Moura Baqueiro, Ana Lúcia Magalhães, Anderson Ricardo Silvestro, Andreia Lucila da Costa Schlosser, Andressa Hennig Silva, et al. Gestão e tecnologia em educação: volume 1. 10.5935, 2018. http://dx.doi.org/10.5935/978-85-7042-003-9.2018b001.
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Bardi, Karina Maria Costa, Ana Paula Duarte, João Luiz Rissardi, Vanessa do Rocio Nahhas Scandelari, Manuel Duarte Pinheiro, Marcela Dutra Tenorio Campany, Maria Christina Barbosa da Costa, et al. Tópicos em Administração - Volume 15. 10.5935, 2018. http://dx.doi.org/10.5935/978-85-7042-024-4.
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SILVA, R. M., ed. Leituras e releituras: estudos literários e seus relatos. Mares Editores, 2016. http://dx.doi.org/10.35417/978-85-5927-003-7.
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BORGES, K. J. S., and C. P. S. BOURGUIGNON, eds. Sobre as mulheres e seus escritos: perspectivas femininas e feministas. Mares Editores, 2016. http://dx.doi.org/10.35417/978-85-5927-024-2.
Full textBook chapters on the topic "004.852, 004.023"
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Curran, Stephanie, and Graeme I. Murray. "An Introduction to Laser-Based Tissue Microdissection Techniques." In Laser Capture Microdissection, 3–7. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-853-6:003.
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Tarazi, Frank I., and Marc J. Kaufman. "Neural Principles of Neurological and Psychiatric Disorders." In Neurological and Psychiatric Disorders, 3–27. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-856-0:003.
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Singh, Sadmeet, and Gurmit Singh. "Overview." In Bone Metastasis, 3–12. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-892-7:003.
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Madea, Burkhard. "Death as a Result of Starvation." In Forensic Pathology Reviews, 3–23. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-872-2:003.
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Brody, Aaron J. "Memories from Tell en-Naṣbeh." In "As for me, I will dwell at Mizpah …": The Tell en-Nasbeh Excavations after 85 Years, edited by Jeffrey R. Zorn, Aaron J. Brody, Alexis T. Boutin, Stephanie H. Brown, Catherine P. Foster, Mary Larkum, Whitney R. McClellan, et al., 23–30. Piscataway, NJ, USA: Gorgias Press, 2014. http://dx.doi.org/10.31826/9781463234980-003.
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"Anthropometry and Physiognomy of 832 Criminals." In Criminal Man, 50–57. Duke University Press, 2006. http://dx.doi.org/10.1215/9780822387800-003.
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"Preface." In The Iberian Peninsula between 300 and 850, 21–22. Amsterdam University Press, 2017. http://dx.doi.org/10.1515/9789048525744-003.
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"Preface." In The Kingship of the Scots, 842-1292, ix—x. Edinburgh University Press, 2016. http://dx.doi.org/10.1515/9781474415453-003.
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TURKOVÁ, A., and L. DONZE. "THE EFFECT OF FIRMS REPORTING TO THE CARBON DISCLOSURE PROJECT ON THEIR CO2 EMISSIONS: APPLICATION ON INDUSTRIAL SECTOR." In WIT Transactions on State-of-the-art in Science and Engineering, 19–26. WIT Press, 2016. http://dx.doi.org/10.2495/sdp-v11-n6-845-852/003.
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Kolditz, Lothar. "Über die Rolle der Gasatmosphäre bei Festkörperreaktionen." In Peter A. Thiessen zum 85. Geburtstag, 23–28. De Gruyter, 1985. http://dx.doi.org/10.1515/9783112548165-003.
Full textConference papers on the topic "004.852, 004.023"
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Cavalli, Jessica, and Anita Cservenka. "Emotion Dysregulation Moderates the Association Between Stress and Problematic Marijuana Use." In 2020 Virtual Scientific Meeting of the Research Society on Marijuana. Research Society on Marijuana, 2021. http://dx.doi.org/10.26828/cannabis.2021.01.000.8.
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Objective. Marijuana is the most widely used illicit substance in the United States and in 2018 alone, an estimated 40.3 million adults reported using marijuana in the past year. This is concerning since growing research suggests that marijuana use is associated with adverse health and life outcomes, such as mental health issues, and cognitive impairment. Thus, determining factors that influence marijuana use-related problems is critical for understanding how to effectively implement prevention, intervention, and treatment efforts. Because research has proposed that emotion dysregulation is a transdiagnostic risk factor for substance use and addiction, the investigation of emotion regulation capabilities in marijuana users is warranted. Furthermore, since prior studies suggest that stress may lead to greater marijuana use-related problems, additional research into how emotion dysregulation may affect these relationships is needed. Thus, the current study examines how emotion dysregulation moderates the association between stress and problematic marijuana use in adults through an online survey. Methods. 852 adults reporting any lifetime marijuana use completed an online survey through Qualtrics. Participants completed a brief demographic questionnaire and were asked to report their past 30-day use of marijuana, alcohol, nicotine, and illicit substances. To assess past month problematic marijuana use, participants completed the Marijuana Problem Scale (MPS). To assess emotion dysregulation, participants completed the Difficulties in Emotion Regulation Scale (DERS). Participants completed the Perceived Stress Scale (PSS) and the Holmes-Rahe Life Stress Inventory (H-RLSI) to assess past month perceived stress and past year stressful life events, respectively. We investigated the association between scores on the DERS, PSS, and H-RLSI with scores on the MPS. Additionally, we conducted hierarchical multiple linear regression models to test whether emotion dysregulation, stress, and their interaction predicted problematic marijuana use. Results. Scores on the DERS (r = .53, p < .001), PSS (r = .13, p < .001), and H-RLSI (r = .32, p < .001) were significantly correlated with scores on the MPS. Additionally, emotion dysregulation (B = .32, p < .001), stressful life events (B = .21, p < .001), and their interaction (B = .07, p = .003) were significant predictors of problematic marijuana use. Finally, emotion dysregulation (B = .44, p < .001), perceived stress (B = -.18, p < .001), and their interaction (B = -.06, p = .04) were significant predictors of problematic marijuana use. Conclusion. These findings indicate that when examined separately, greater emotion dysregulation, experiencing more stressful life events in the past year, and experiencing more perceived stress in the past month were associated with greater problematic marijuana use in the past month. However, when examining the moderating role of emotion dysregulation, more stressful life events and less perceived stress predicted greater problematic marijuana use, and these associations were stronger at higher levels of emotion dysregulation. Overall, these results suggest that emotion dysregulation and greater stress may be risk factors for developing problematic marijuana use, and could be possible targets for prevention, intervention, and treatment efforts.
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Kim, Min-Soo, and Sang-Hee Kang. "A CT Saturation Detection Algorithm Based on the Analysis of the Saturated Current Using Wavelet Transformation." In Modelling, Simulation and Identification / 854: Intelligent Systems and Control. Calgary,AB,Canada: ACTAPRESS, 2017. http://dx.doi.org/10.2316/p.2017.853-024.
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Shahbaz, Muhammad, Sajida Parveen, Aziz Guergachi, and Karim Keshavjee. "Performance Analysis of Clinical Abbreviation Disambiguation Using Machine Learning Techniques." In Modelling, Simulation and Identification / 854: Intelligent Systems and Control. Calgary,AB,Canada: ACTAPRESS, 2017. http://dx.doi.org/10.2316/p.2017.854-003.
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Zhou, Yuanxin, Peixuan Wu, Zhongyang Cheng, Biddut Kanti Dey, and Shaik Jeelani. "Effect of Carbon Nanotube on Electrical, Thermal and Mechanical Properties of Epoxy." In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-41503.
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In this study, electrical, thermal and mechanical properties of multi-walled carbon nanotubes (CNTs) reinforced Epon 862 epoxy have been evaluated. Firstly, 0.1 wt%, 0.2 wt%, 0.3 wt%, and 0.4 wt% CNT were infused into epoxy through a high intensity ultrasonic liquid processor and then mixed with EpiCure curing agent W using a high speed mechanical agitator. The trapped air and reaction volatiles were removed from the mixture using a high vacuum. Neat epoxy sample also was made as reference. Electrical conductivity, dynamic mechanical analysis (DMA, three point bending tests and fracture tests were performed on unfilled, CNT-filled epoxy to identify the loading effect on the properties of composites. Experimental results show significant improvement in electric conductivity. The resistivity of epoxy decreased to 15Ωm with 0.4% CNT. DMA studies revealed that filling the carbon nanotube into epoxy can produce a 90% enhancement in storage modulus and a 17° C increase in Tg, but CNT has little effect on decomposing temperature. Mechanical test results showed that modulus increased with higher CNT loading percentages, but the 0.3 wt% CNT-infusion system showed the maximum strength and fracture toughness enhancement. The decrease in strength and fracture toughness in 0.4% CNT/epoxy was attributed to poor dispersions of nanotubes in the composite.
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Silva Júnior, Mário Luciano de Mélo da, Marcos Vinícius de Souza Vilanova, and Matheus Franco Andrade Oliveira. "Different names for stroke: same concept?" In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.285.
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Background: In Brazil, a number of names are used to refer to a stroke event, such as “spill”, “thrombosis”, and “beginning of stroke”. Objective: To analyze the attitudes (call to the emergency service and refer a hospital as the best treatment site) of individuals who identify a “stroke setting” in comparison to other terms.Design and setting: Cross-sectional study involving 1,477 individuals (36,4±14.8years, 52.5% female, 13,0±4,4 schooling years) from Brazil’s northeastern.Methods: We applied a survey to volunteers who were on public areas. The researcher exposed the volunteers to a typical case of stroke and asked “what is happening with this person?”, “what should you do in this situation” and “what is the best place to medically treat this person?”Results: 825/1477 (55.9%) answered “stroke”, 26.4% “spill”, 7.7% “infarction” and 2.6% “thrombosis”; 16.9% did not define what happened. Calling to the emergency service was the attitude of 592 (40.1%). A hospital was the best place for 75.4%. Individuals who answered “spill” were more often men (p<.001), nonwhite (p=.050), from Bahia state (p<.001) and had fewer years of education (p=.001). Individuals who answered “thrombosis” and “beginning of stroke” were older (p=.046) and of poorer education (p=.026). The answer to “what to do” and “best place for treatment” was not different among any of these groups. Conclusion: Despite demographic and regional differences in how to name a stroke event, the idea related to them is the same. Awareness campaigns should use other terms than stroke to improve the comprehension of lay population.
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Collins, R. "RANDOMIZED FACTORIAL TRIAL OF HIGH-DOSE INTRAVENOUS STREPTOKINASE, OF ORAL ASPIRIN, AND OF INTRAVENOUS HEPARIN IN ACUTE MYOCARDIAL INFARCTION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643623.
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619 patients with suspected acute myocardial infarction (MI) were randomized to receive either a high-dose short-term intravenous infusion of streptokinase (1.5 MU over one hour) or placebo. In addition, using a “2x2x2 factorial” design, patients were also randomized to receive either oral aspirin (325 mg on alternate days for 28 days) or placebo, and separately randomized to receive either intravenous heparin (1,000 IU/hour for 48 hours) or no heparin. Streptokinase (SK) was associated with a non-significant decrease in hospital mortality (7.7% allocated SI< vs 9.2% allocated placebo) and increase in non-fatal reinfarction (3.6% vs 2.9%). There were significantly more minor adverse events after SK (e.g. hypotension, allergies, bruises or minor bleeds), but no excess of strokes or of anaphylactic shock.Aspirin was associated with fewer reinfarctions (2.9% allocated aspirin vs 3.9% allocated placebo; NS), deaths (6.1% vs 10.5%; 2P<0.04) and strokes (0.3% vs 2.0%; 2P<0.1).Heparin was associated with a decrease in reinfarction (1.9% allocated heparin vs 4.9% allocated no heparin; 2P<0.04), though not in mortality (8.3% vs 8.2%; NS), and with a trend towards more strokes (1.6% vs 0.7%; NS) and more bruising and bleeding (14% vs 11%; NS). To assess reliably the effects of SK and aspirin on major endpoints, several hundred hospitals are now collaborating in a large (about 20,000 patients planned) randomized trial (ISIS-2).
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Jiménez, Rafael, Elena Gervilla, Clarisse Guimarães, Neus Nicolau, and Albert Sesé. "Tasa de alcohol por aire espirado y perfiles de los consumidores de alcohol y policonsumidores en botellones." In 22° Congreso de la Sociedad Española de Patología Dual (SEPD) 2020. SEPD, 2020. http://dx.doi.org/10.17579/sepd2020p077.
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Se perfilan las características diferenciales de los consumidores de alcohol en botellones frente a policonsumidores que adicionalmente consumían cannabis y/o tabaco. La muestra está formada por 1387 jóvenes entre 14 y 35 años (M=21.73, SD=3.69, 8.2% menores de edad), y un 51.8% de hombres. Los participantes fueron seleccionados en botellones celebrados en la ciudad de Palma y se registró la tasa de alcohol por aire espirado (Zaphir CDP 3500), e información adicional mediante encuesta sobre consumo in situ de otras drogas, y sobre otras variables relacionadas con el uso de alcohol. El 80.1% de los participantes presentaron una tasa de alcohol por aire espirado superior a 0 mg/l (seleccionados para delimitar los clústeres), y el 34.9% superior a 0.25 mg/l. Los resultados indican que el perfil del clúster de consumidores de alcohol (sin policonsumo, n=524) presenta diferencias en determinadas variables respecto a otros clústeres en los que sí existe policonsumo (alcohol + tabaco: n=306; alcohol + cannabis: n=142 ; alcohol + tabaco + cannabis: n=87). En concreto, se observa una tasa media de alcohol inferior en el clúster sin policonsumo (M=0.263, SD=0.237), siendo significativa la diferencia respecto al clúster de alcohol + tabaco (M=0.313, SD=0.260, p =.03). El porcentaje de casos con tasa de alcohol superior a 0.25 mg/l se incrementa significativamente en los tres clústeres de policonsumo (Ji-cuadrado(3,N=1059)=18.12, p<.001). El patrón porcentual respecto al sexo también varia de manera significativa por clústeres (Ji-cuadrado(3,N=1059)=39.97, p<.001), disminuyendo notablemente el porcentaje de mujeres cuando aparece el cannabis asociado al alcohol, e incrementándose cuando se asocia exclusivamente con tabaco. La variable edad no varía de manera significativa entre clústeres. Por consiguiente, los resultados sugieren que la perspectiva de género y el policonsumo deben ser tenidos en cuenta a la hora de diseñar actuaciones preventivas eficaces en el consumo de alcohol en botellones.
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Conceição, Jamille Karoyne da, and Ana Paula de Mello. "Malnutrition associated with Wallenberg Syndrome: Case report." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.599.
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Introduction: Wallenberg Syndrome (SW) is characterized by the condition of swallowing impairment, and nutritional assessment is essential to prevent weight loss. Objective: To report a case of malnutrition associated with SW. Methods: Report of malnutrition in a patient diagnosed with SW in a public hospital in Santa Catarina-Brazil. Results: Elderly, 67 years old, male, retiring, systemic arterial hypertension story and ischemic stroke (without sequelae). He sought assistance on 03/17/2020 in a public hospital in Joinville/SC reporting dysphagia and vertigo, being admitted for investigation of a new vascular event. During hospitalization, he presented: constipation, vertigo, hoarseness, odynophagia, hiccups, regurgitation, emesis, heartburn and drooling. He underwent cranial magnetic resonance imaging confirming infarction in a left posterior-lateral bulb, with a vertebral lesion in the V4 portion, characterizing the SW. He underwent a videodeglutogram, showing a risk of silent bronchoaspiration and with prolonged rehabilitation time, making it necessary to choose an alternative feeding route, initially a nasoenteral tube. Initial anthropometric assessment (03/17/2020): BMI 27.47 kg/m² (height: 163 cm, weight: 73 kg). During hospitalization there was a reduction of -7.9 kg (final weight 65.1 kg; BMI 24.3 kg/m², totaling 10.82% loss (04/23/2020) in 1 month (considered severe). Brachial circumference decreased from 31 (03/24) to 28 cm (04/10). On physical examination: distended abdomen, loss of muscle mass at the temples and subcutaneous fat (biceps). This abrupt nutritional loss was associated with low diet tolerance gastrointestinal night infusion and volumes above 85 ml/h, making it impossible to reach a nutritional goal, he was discharged with gastrostomy, continued to undergo rehabilitation with a speech therapist at home and after 3 months he returned to exclusive oral feeding. Conclusion: Patients diagnosed with SW should be monitored about diet tolerance and to avoid risk of complications associated with weight loss and risk of bronchoaspiration.
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Fernandes, Priscilla Neves, JORGE ANTONIO FILHO, ALINE DE AMORIM DA SILVA, FERNANDA WERNECK DE MATTOS MOURA, and RUBIA CANTARIN DE SOUZA. "RELATO DE CASO: LEPTOSPIROSE GRAVE SEM ICTERÍCIA." In II Congresso Nacional de Microbiologia Clínica On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conamic/02.
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Introdução: A leptospirose é uma doença infecciosa febril de início abrupto, cujo espectro clínico pode variar desde um processo inaparente, até as formas graves. Objetivo: Enfatizar sobre importância do médico em suspeitar de leptospirose, mesmo sem a presença de icterícia. Material e métodos: Foi realizado a coleta de dados de um paciente atendido na Unidade de Pronto Atendimento de Sepetiba, em maio de 2017. Resultados: Paciente, J.S.S, masculino, 38 anos, trabalha como gari há 13 anos, dá entrada relatando que há 03 dias iniciou quadro de febre aferida (38,5 oC), mialgia, lombalgia e cefaleia de início súbito, há 1 dia vem apresentando tosse seca e dispneia aos médios esforços, evoluindo com um quadro de tosse com expectoração hemoptoicas e piora progressiva da dispneia. Ao exame: acordado, confuso, obedecendo aos comandos, taquidispneico com cianose de extremidades (FR 40 irpm e SatO2 85%), taquicárdico (FC 130 bpm), hipotenso (PA 80 x 50 mmhg), desidratado +/+4, hipocorado (++/4+), anictérico, febril (39 oC). Apresenta murmúrio vesicular universalmente audível com presença de crepitação na base esquerda. Impressões diagnósticas: IRA / H1N1, Dengue hemorrágica e Leptospirose. Foi encaminhado imediatamente para sala vermelha, para cuidados intensivos. Exame laboratorial demostrou hematócrito: 28% com hemoglobina de 10 g/l, leucocitose com neutrofilia e desvio à esquerda, plaquetas 80.000. Bilirrubina total: 2,1 mg/dL; bilirrubina direta: 0,4 mg/dL; Gasometria arterial: alcalose respiratória; Radiografia de tórax apresenta condensação à esquerda. Após 3 horas de internação o paciente apresentou piora do quadro respiratório, evoluindo com síndrome da angústia respiratória aguda, sendo realizado intubação orotraqueal com presença de hemorragia pulmonar maciça, logo em seguida evolui para parada cardiorrespiratória sem reversão e óbito. Após 48 horas foi confirmado sorologia para leptospirose. Conclusão: É importante observar que manifestações graves da leptospirose, como hemorragia pulmonar, podem ocorrer em pacientes anictéricos, portanto, não se deve basear apenas na presença de icterícia para identificar pacientes com leptospirose ou com risco de complicações graves da doença, aumentando as chances de letalidade, pois os casos com comprometimento pulmonar podem evoluir para insuficiência respiratória aguda, hemorragia maciça ou síndrome de angústia respiratória e muitas vezes, esse quadro precede o quadro de icterícia.
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Woodward, Kelsey, Annalee Ellis, Jenni Teeters, and Matthew Woodward. "Examining Associations Between Trauma Exposure and Cannabis Use Frequency, Quantity, Duration, and Age of Onset." In 2020 Virtual Scientific Meeting of the Research Society on Marijuana. Research Society on Marijuana, 2021. http://dx.doi.org/10.26828/cannabis.2021.01.000.39.
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Prior research has identified an association between trauma exposure and cannabis use, such that a history of trauma exposure is associated with greater likelihood of lifetime cannabis use. However, little research has expanded upon this association, making it unclear whether trauma exposure is associated with cannabis use outcomes beyond lifetime history of use. Given that heavy cannabis use and trauma exposure are risk factors for a number of deleterious outcomes, it is important to further examine the influence of trauma exposure on cannabis use. The purpose of the current study was to further explore this relationship by examining associations between trauma exposure and various indices of cannabis use. Participants included a sample of 722 female undergraduates at least 18 years or older (M = 19.0) who were recruited through a campus-wide online study pool. Participants completed measures on trauma exposure (calculated as number of traumas experienced), cannabis use (i.e., Daily Sessions, Frequency, Age of Onset, and Quantity of Cannabis Use [DFAQ-CU]; Cutler & Spradlin, 2017), and mental health symptoms. Specific indices of cannabis use were lifetime history of cannabis use, age of onset of cannabis use, current frequency of use, current quantity of use (in grams), and length of use. Logistic regression analyses and correlations were used to explore the associations between trauma and cannabis use variables. Subsequent analyses were conducted controlling for posttraumatic stress disorder (PTSD) symptoms to determine whether relationships between trauma exposure and cannabis use remained after accounting for PTSD symptoms. Thirty-seven percent (n = 266) of the sample indicated a lifetime history of cannabis use. Similar to previous research, greater trauma exposure was significantly associated with a greater likelihood of a lifetime history of cannabis use (OR = 1.14, p < .001). Additionally, number of traumas experienced and age of onset of cannabis use were significantly negatively correlated, r(262) = -.16, p < .01, indicating that greater trauma exposure was associated with earlier onset of use. Number of traumas experienced was positively correlated with duration of cannabis use, r(236)=.14, p = .03, indicating greater trauma exposure was associated with greater duration of use. Number of traumas experienced was also positively correlated with quantity of cannabis use, r(175)=.20, p < .01, showing that greater trauma exposure was associated with higher amounts of cannabis used. These associations remained significant even after controlling for PTSD symptoms. Frequency of cannabis use was not significantly correlated with trauma exposure, r(266) = -.01, p = .82. The results of the present study indicate that trauma exposure is associated with a range of indices of cannabis use beyond lifetime history of use, even after accounting for the influence of PTSD. These findings highlight the importance of extending examination of trauma and cannabis beyond frequency of use. Although trauma exposure may serve as a risk factor for elevated cannabis use, it is also possible that cannabis use may increase the risk of trauma exposure. Future studies should explore these associations longitudinally as well as examine the mechanisms that link these outcomes together.
Reports on the topic "004.852, 004.023"
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Health hazard evaluation report: HETA-85-003-1834, B. F. Goodrich, Woodburn, Indiana. U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, September 1987. http://dx.doi.org/10.26616/nioshheta850031834.
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