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Journal articles on the topic "004.77 004.896"
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Agarwalla, Avinesh, Anirudh K. Gowd, Joseph N. Liu, Simon P. Lalehzarian, David R. Christian, Brian J. Cole, Brian Forsythe, and Nikhil N. Verma. "Predictive Factors and Duration to Return to Sport After Isolated Meniscectomy." Orthopaedic Journal of Sports Medicine 7, no. 4 (April 1, 2019): 232596711983794. http://dx.doi.org/10.1177/2325967119837940.
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Background: Return to sport (RTS) after meniscectomy is an important metric for young, active patients. However, the impact of the duration from surgery to RTS on clinical outcomes is not fully understood and is not reflected in outcome scores. Purpose: To establish when patients RTS after meniscectomy and to determine predictive measures for the ability to return to their preinjury activity. Study Design: Case-control study; Level of evidence, 3. Methods: All patients undergoing meniscectomy between 2016 and 2017 from a single institution were assessed for inclusion. RTS, type of activity, and level of function upon returning were obtained. The minimal clinically important difference (MCID), substantial clinical benefit, and patient acceptable symptom state (PASS) were calculated for the Knee injury and Osteoarthritis Outcome Score (KOOS) and International Knee Documentation Committee (IKDC) questionnaire using anchor-based and distribution-based approaches. Preoperative knee-specific and generic quality-of-life scores were analyzed to determine their predictive power of RTS. A multivariate logistical analysis was also performed to determine which demographic variables corresponded to RTS. Results: Overall, 94 patients (mean age, 51.0 ± 11.1 years) who underwent meniscectomy participated in sports within 6 months of surgery. Of these patients, 76.6% returned to sport without permanent restrictions at a mean of 8.6 ± 6.9 weeks postoperatively. RTS rates for low-, medium-, and high-intensity activities were 75.0%, 70.0%, and 82.5%, respectively. RTS was associated with achieving the PASS for the KOOS–Physical Function short form (PS), KOOS-Pain, and KOOS-Sports ( P = .004, P = .007, and P = .006, respectively) but not for the IKDC questionnaire ( P = .3). Achieving the MCID was associated with RTS for the KOOS-Sports, KOOS-Pain, and IKDC questionnaire ( P < .001, P = .03, and P = .001, respectively). There was no preoperative or intraoperative variable that was predictive of RTS. Preoperative KOOS-PS scores ≥37.8 (area under the curve = 76.3%) and KOOS-Pain scores ≥51.4 (area under the curve = 72.5%) were predictive of RTS. Conclusion: Approximately 77% of patients returned to sport after meniscectomy at a mean of 2 months postoperatively. The level of activity intensity did not significantly alter the rate of RTS. Higher preoperative scores on the KOOS-PS and KOOS-Pain were predictive of RTS. Identifying these factors allows physicians to counsel patients on expected outcomes after meniscectomy.
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Gómez-Seguí, Inés, Esperanza Such, Jose Cervera, Pascual Fernandez, Lurdes Zamora, Mara Andres, Irene Luna, et al. "Gene Microdeletions in Adult and Pediatric Acute Lymphoblastic Leukemia,." Blood 118, no. 21 (November 18, 2011): 3539. http://dx.doi.org/10.1182/blood.v118.21.3539.3539.
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Abstract Abstract 3539 Background: Microdeletions of genes involved in B lymphopoiesis and cell-cycle regulation, such as CDKN2A/B, PAX5, IKZF1, ETV6, RB1, BTG1 and EBF1 have been reported as a frequent event in pediatric acute lymphoblastic leukemia (ALL). Whether these findings are found in adulthood and the possible differences with childhood ALL, as well as its prognostic implication, are still unknown. Aims: To assess the differences between two cohorts of children and adults diagnosed with ALL on the frequency of deletions in these genes and their relationship with clinical data and prognosis. Methods: We studied 70 children and 83 adults diagnosed with ALL with available DNA sample at diagnosis. In children, median age was 4y. (1 – 14), median leukocytes 10.3×109/L (0.7 – 675) and the cytogenetic risk distribution was 42(39%), 30(27%) and 12(11%) for favourable [t(12;21) and hyperdiploidy], intermediate (normal karyotype and miscellaneous) and high risk [t(9;22), t(4;11), hypodiploid and complex karyotype], respectively. In adults, median age was 38y. (15 – 85), median leukocytes 16.8×109/L (1 – 371) and 29(35%) patients belonged to the high risk cytogenetic group. We performed Multiplex Ligation Probe Amplification (MLPA) using SALSA kit P335-A1 (MRC-Holland). PCR products were separated on an ABIPRISM 310 DNA Analyzer and analyzed using GeneMapper v3.2 (Applied Biosystems). Results: Frequency of deletions in the studied genes was similar in children and adults, except for IKZF1 deletions that were more frequent in adults (P<.001) (Table 1). In children, ETV6 deletions occurred more frequently in patients with t(12;21) (67% of patients with deletion vs. 17% without, P <.001); CDKN2A/B deletions were found in patients assigned to the intermediate cytogenetic risk group (59% of patients with deletion vs. 23% without, P =.028); and the three cases with RB1 deletions were found in patients with hypodiploidy (P <.001). In adults, ETV6 and CDKN2A/B deletions occurred more frequently in women (67% vs. 39%, P =.022 and 77% vs. 42%, P =.021, for patients with and without deletions, respectively); PAX5 and IKZF1 deletions appeared more frequently in patients with >30×109/L leukocytes (60% vs. 27%, P =.032 and 52% vs. 21%, P =.007, for patients with and without deletions, respectively); besides, PAX5 deletions occurred in patients who belonged to the standard cytogenetic risk group (55% vs. 6% for patients with and without deletions, P <.001). In the pediatric cohort, the leukocytes >30×109/L and the cytogenetic risk group were the variables that reached statistical significance for both overall survival (OS) and relapse free survival (RFS) and also age >10y. for OS, but in the multivariate analyses, just the cytogenetic risk classification remained significant [HR: 4 (CI 95%: 1.6 – 10), P =. 004 for OS and HR: 3.5 (CI 95%: 1.7 – 7.2), P =. 001 for RFS]. In the adult cohort, multivariate analysis for OS including all significant variables in the univariate analysis (age >60y, karyotype, CDKN2A/B and ETV6 deletions) showed as independent variables: age >60y. [HR: 4.3 (CI 95%: 2.1 – 8.6), P<. 001] and CDKN2A/B deletions [HR: 2.6 (CI 95%: 1.4 – 5.3), P=. 004]. Similarly, taking into account karyotype, CDKN2A/B and ETV6 deletions for the RFS multivariate analyses, just ETV6 deletions arose as an independent factor [HR: 3.8 (CI 95%: 1.5 – 9.4), P=. 004]. In fact, having CDKN2A/B and/or ETV6 deletions conferred a worse prognosis to patients in both standard risk cytogenetic group (3y. RFS: 45% vs. 70% for patients with and without deletions, respectively; P =.049) and high risk cytogenetic group (3y. RFS: 14% vs. 66% for patients with and without deletions, respectively; P =.025). Conclusions: This study shows the high incidence of deletions in genes of cell-cycle and B-lymphopoiesis in adult and pediatric ALL. However, the biological and prognostic implications of these deletions seem to differ between both patient groups: while cytogenetics was the strongest variable for risk assessment in children, gene microdeletions in CDKN2A/B and ETV6 added a prognostic value to karyotype in our adult cohort. Fundings: AP-194/10, R06/0020/0031, BES2008–008053, CM10/00321, CM09/00038, and CA08/00141. Disclosures: No relevant conflicts of interest to declare.
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Castro, Elena, Chee Goh, David Olmos, Ed Saunders, Daniel Leongamornlert, Malgorzata Tymrakiewicz, Nadiya Mahmud, et al. "Germline BRCA Mutations Are Associated With Higher Risk of Nodal Involvement, Distant Metastasis, and Poor Survival Outcomes in Prostate Cancer." Journal of Clinical Oncology 31, no. 14 (May 10, 2013): 1748–57. http://dx.doi.org/10.1200/jco.2012.43.1882.
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Purpose To analyze the baseline clinicopathologic characteristics of prostate tumors with germline BRCA1 and BRCA2 (BRCA1/2) mutations and the prognostic value of those mutations on prostate cancer (PCa) outcomes. Patients and Methods This study analyzed the tumor features and outcomes of 2,019 patients with PCa (18 BRCA1 carriers, 61 BRCA2 carriers, and 1,940 noncarriers). The Kaplan-Meier method and Cox regression analysis were used to evaluate the associations between BRCA1/2 status and other PCa prognostic factors with overall survival (OS), cause-specific OS (CSS), CSS in localized PCa (CSS_M0), metastasis-free survival (MFS), and CSS from metastasis (CSS_M1). Results PCa with germline BRCA1/2 mutations were more frequently associated with Gleason ≥ 8 (P = .00003), T3/T4 stage (P = .003), nodal involvement (P = .00005), and metastases at diagnosis (P = .005) than PCa in noncarriers. CSS was significantly longer in noncarriers than in carriers (15.7 v 8.6 years, multivariable analyses [MVA] P = .015; hazard ratio [HR] = 1.8). For localized PCa, 5-year CSS and MFS were significantly higher in noncarriers (96% v 82%; MVA P = .01; HR = 2.6%; and 93% v 77%; MVA P = .009; HR = 2.7, respectively). Subgroup analyses confirmed the poor outcomes in BRCA2 patients, whereas the role of BRCA1 was not well defined due to the limited size and follow-up in this subgroup. Conclusion Our results confirm that BRCA1/2 mutations confer a more aggressive PCa phenotype with a higher probability of nodal involvement and distant metastasis. BRCA mutations are associated with poor survival outcomes and this should be considered for tailoring clinical management of these patients.
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Goekbuget, Nicola, Anja Baumann, Joachim Beck, Monika Brueggemann, Helmut Diedrich, Andreas Huettmann, Lothar Leimer, et al. "PEG-Asparaginase Intensification In Adult Acute Lymphoblastic Leukemia (ALL): Significant Improvement of Outcome with Moderate Increase of Liver Toxicity In the German Multicenter Study Group for Adult ALL (GMALL) Study 07/2003." Blood 116, no. 21 (November 19, 2010): 494. http://dx.doi.org/10.1182/blood.v116.21.494.494.
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Abstract Abstract 494 Several randomised pediatric trials have demonstrated that intensification of Asparaginase (ASP) treatment in ALL can contribute to improved outcome. In adult ALL few data are availabe and optimal ASP preparation, schedule and intensity with respect to efficacy and tolerability have to be defined. The optimisation of ASP treatment is therefore an essential aim of the GMALL. Treatment: Induction treatment of the ongoing study 07/2003 consists of dexamethasone, vincristine, daunorubicine, pegylated asparaginase (PEG-ASP) (phase I), mercaptopurine, cyclophosphamide and cytarabine (phase II) as previously described (Brueggemann et al, Blood 2006: 107; 1116). During the study the dose for PEG-ASP was increased from 1000 to 2000 U/m2 in induction and from 500 to 2000 U/m2 in consolidation (combined with HDMTX and MP) for pts aged between 15 and 55 years. 1 application for high risk and 7 applications for standard risk (SR) were scheduled during the first year and the aim was improvement of overall survival (OS) and remission duration (RD). Patients: From more than 100 centers in Germany 1226 pts with a median age of 35 (15-55) yrs were evaluable. 826 pts were treated with 1000 U/m2 (cohort 1) and 400 pts with 2000 U/m2 (cohort 2) and both groups were comparable regarding major entry criteria. The analysis was restricted to pts who received one of the scheduled PEG-ASP doses during induction. Outcome: CR rate after induction was 91% vs 91% in cohort 1 and 2 resp., with comparable rates for early death (4% vs 5%) and failure (5% vs 4%). Data on molecular response (MRD below 10−4) after induction are available in a subset and showed no difference between both cohorts after induction (79% vs 82%). OS after 3 years was improved in cohort 2 (60% vs 67%; p>.05). The positive effect was specifically evident in SR patients (N=407 vs 190) with respect to OS (68% vs 80%; p=.02) and RD (61% vs 74%; p=.02). It was demonstrated in younger pts (15-45 yrs) (71% vs 82%; p=.02) and older pt (45-55 yrs) (56% vs 74%; p>.05). Excellent results were achieved in young adults (15-25 years) with respect to OS (77% vs 86%; p>.05) and RD (60% vs 78%; p>.05). Toxicity: The analysis of toxicity was focused on grade III-IV events during induction with potential correlation to PEG-ASP (764/382 pts in cohort 1/cohort 2)). Incidences are as follows: GOT or GPT (30%/30%), bilirubine (10%/16%), thrombosis (5%/5%) and hypersensitivity (<1%/<1%). In a subset of pts additional AEs were assessed as amylase (5%/13%), lipase (23%/15%) and glucose (10%/12%). Significantly less toxicity was observed during consolidation cycles. Bilirubine °III/IV occurred median 16d after PEG-ASP during phase II of induction. In univariate analysis it was correlated to dose (10% vs 16%; p=.004), age <> 45 yrs (11% vs 17%; p=.005), BMI <> 30 (12% vs 18%; p=.04) and rituximab application (11% vs 18%; p=.009). Hepatomegaly, infections or imatinib application had no significant effect. In multivariate analysis dose and age remained independent significant prognostic factors. Bilirubine increase during induction was associated with treatment delays and inferior prognosis. Conclusions: This is the largest cohort of adult ALL treated with PEG-ASP. Due to prolonged activity fewer applications are required which is a pre-requisite for realisation of ASP intensification in the context of an intensive multidrug chemotherapy for adult ALL. Although CR rate and molecular CR were not significantly improved PEG-ASP intensification was associated with an improved OS and RD. The improvement was specifically evident in SR pts treated with up to 7 doses of PEG-ASP. Overall intensified PEG-ASP was feasible. The rate of grade III-IV bilirubine elevation increased after dose escalation and led to treatment delays in individual pts which were prognostically relevant. It would be an important goal to identify parameters to predict severe ASP related toxicity. Further intensification of ASP by additional applications would be of interest. Supported by Deutsche Krebshilfe 70–2657-Ho2 and partly BMBF 01GI 9971 and Medac GmbH. Disclosures: Goekbuget: Medac: Consultancy, Research Funding, Speakers Bureau. Hoelzer: Medac: Speakers Bureau.
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Kireeva, Irina V., Yuriy I. Chumlyakov, Zinaida V. Pobedennaya, Anna V. Vyrodova, and Anastasia A. Saraeva. "High-Strength Behavior of the Al0.3CoCrFeNi High-Entropy Alloy Single Crystals." Metals 10, no. 9 (August 26, 2020): 1149. http://dx.doi.org/10.3390/met10091149.
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The main disadvantage of fcc (face-centred cubic lattice) high-entropy alloys is the low stress level at the yield point (σ0.1) at a test temperature above room temperature. This restricts their practical application at high test temperatures from 773 K to 973 K. In this study, we found that a high stress level was reached at the yield point σ0.1 ≈ G/100–G/160 (G is the shear modulus) of the [001]- and [1¯44]-oriented crystals of the Co23.36Cr23.29Fe23.80Ni21.88Al7.67 (Al0.3CoCrFeNi) high-entropy alloy (HEA) within a wide temperature range of 77–973 K under tension, due to the occurrence, of nanotwins, multipoles, dislocations under plastic deformation at 77 K and the subsequent precipitation of ordered L12 and B2 particles. It was shown that grain boundaries are not formed and the samples remain in a single-crystal state after low-temperature deformation and subsequent ageing at 893 K for 50 h. Achieving a high-strength state in the Al0.3CoCrFeNi HEA single crystals induces the orientation dependence of the critical resolved shear stresses (τcr) at T ≥ 200 K (τcr[1¯44] > τcr[001]), which is absent in the initial single-phase crystals, weakens the temperature dependence of σ0.1 above 573 K, and reduces plasticity to 5–13% in the [1¯44] orientation and 15–20% in the [001] orientation.
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Symons, Martyn CR, and Raymond E. March. "Possible structures for H-Cu-CH3 molecules." Canadian Journal of Chemistry 79, no. 2 (February 1, 2001): 124–26. http://dx.doi.org/10.1139/v01-004.
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EPR spectra for H-Cu-CH3 molecules in glasses at 77 K show 63Cu hyperfine splitting that accords with a d1x2 y2 orbital for the semi-occupied molecular orbital (SOMO) rather than a d1z2 SOMO. The g-values also strongly imply a d1x2 y2 configuration. The estimated spin densities on the H- and -CH3 ligands are small. It is argued that the molecule must be strongly bent in order to favour this SOMO and that this bending may be induced by weak solvation.Key words : H-Cu-CH3, EPR spectra, molecular structure, hyperfine splitting.
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Nham, Benjamin, Nicole Reid, Emma Argaet, Allison Young, Kendall Bein, Gabor M. Halmagyi, and Miriam S. Welgampola. "004 Vestibular event monitoring in the emergency department." Journal of Neurology, Neurosurgery & Psychiatry 90, e7 (July 2019): A2.1—A2. http://dx.doi.org/10.1136/jnnp-2019-anzan.4.
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IntroductionAcute vertigo is often accompanied by ictal-nystagmus which may assist with diagnosis. We examine the merits of a structured assessment combined with vestibular event-monitoring in the Emergency Department (ED).MethodsWe undertook a structured clinical assessment and video-nystagmography in 220 non-consecutive patients presenting to a public-hospital ED with acute vertigo, during a 10-month period. The records of 115 consecutive vertiginous patients who underwent standard-assessment were compared.ResultsFor the structured assessment group: 54% presented with acute vestibular syndrome (AVS), 24% with episodic spontaneous vertigo (EVS), and 20% with recurrent positional-vertigo (RPV).For AVS (n=119), most common diagnoses were vestibular neuritis (34%), stroke (34%) and vestibular migraine (13%). Nystagmus slow-phase velocity (SPV) for VN, stroke and VM were 11±5.5o/s, 5.6±2.5o/s, 5.4±5.9o/s; Mean ipsilesional video-head impulse gains were 0.51±0.29, 0.89±0.20 and 0.96±0.13. For EVS(n=53), diagnoses included vestibular migraine (63%), Meniere’s Disease (11%) and others (26%). Nystagmus SPV was 5.4±3.6o/s, 7.6±6.3o/s, 4.1±1.5o/s. In RPV (n=43), common diagnoses were posterior-canal BPPV (66%), horizontal-canal BPPV (23%), migraine (7%). Positional nystagmus SPV profile showed Peak SPV of 42.5o/s, 77.6o/s, 20.64o/s and Time-constants of 6.52s, 22.51s, 34.56s for Posterior-canal BPPV, Horizontal-canal BPPV and Atypical Positional-Vertigo. A final diagnosis was reached in 96% of patients.In the ED control group, only 77% were separated into spontaneous or positional-vertigo. A diagnosis was provided in 57% and was concordant with the history and examination in 34%.ConclusionVestibular event-monitoring and structured clinical assessment secured a diagnosis in 96% of cases compared with 34% for the control group, reinforcing its merit.
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Sanabria Rojas, Hernán, Carolina Tarqui-Mamani, Juan Arias Pachas, and Nelly Lam Figueroa. "Impacto de la fortificación de la harina de trigo con ácido fólico en los defectos del tubo neural, en Lima, Perú." Anales de la Facultad de Medicina 74, no. 3 (October 15, 2013): 175. http://dx.doi.org/10.15381/anales.v74i3.2631.
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En los últimos años, estudios observacionales en algunos países de América Latina y el mundo demostraron una asociación favorable entre la fortificación de la harina con ácido fólico y la reducción de casos con defectos del tubo neural (DTN). Objetivos: Determinar la tasa de incidencia global (TIG) de DTN y su reducción en el periodo posfortificación (2006-2010) de la harina de trigo con ácido fólico. Diseño: Observacional, descriptivo y retrospectivo. Lugar: Instituto Nacional Materno Perinatal INMP, Lima, Perú. Participantes: Recién nacidos entre los años 2006-2010. Intervenciones: Se revisó 88 236 historias clínicas de recién nacidos. Se obtuvo promedios, desviación estándar, frecuencias absolutas y relativas; la tendencia de las incidencias fue medida con Prais Winsten. Se calculó el IC 95% para la TIG con la prueba de Poissón. Principales medidas de resultados: Tasa de Incidencia global de DTN. Resultados: Hubo 77 historias de RN con DTN, que representaron una TIG de 8,73 por 10 000 (IC 95%: 6,9 a 10,9), siendo la incidencia más alta 15,6 x 10 000 (IC 95%: 10,2 a 22,9) el año 2006 y la más baja 7,6 por 10 000 (IC95%: 4,1 a 13,0) el año 2010. Las incidencias de los tipos DTN fueron: espina bífida 6,7 por 10 000 (IC 95%: 5,1 a 8,6), anencefalia 1,9 por 10 000 (IC 95%: 1,1 a 3,1) y encefalocele 1 por 10 000 (IC 95%: 0,1 a 0,6). Conclusiones: La incidencia de los DTN en el INMP disminuyó a 8,7 por 10 000 RN en el periodo posfortificación (2006-2010) de la harina de trigo con ácido fólico, evidenciando impacto positivo de la intervención.
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A.P., Ilin, Kochetkov S.P., Bryl S.V., and Rukhlin G.V. "Problems and prospects of usage of secondary products of processing of natural phosphates for construction materials." Ekologiya i stroitelstvo 4 (2016): 21–29. http://dx.doi.org/10.35688/2413-8452-2016-04-004.
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In the article the problems and prospects of using of secondary products of processing of natural phosphates for obtaining building materials. This technology for production of complex fertilizers is carried out on a Chemical enterprises in Russia: Veliky Novgorod, Dorogouge and Kirovo-Chepetsk. It is noted that from 1 ton of P2O5 of apatite it is produced of CaCO3 about 80 kg. Total output of manmade chalk if you use apatite concentrate represented 896 thousand ton and does not solve the problem of the shortfall of cement in Russia technogenic raw materials, in addition, all obtained in this process, liquid wastes and solid by-products are utilized within these companies without reference to the construction industry. To use the maximum amount of phosphogypsum waste produced by the best Perera-motivate on the spot in sulphuric acid, the who-rotated in the manufacturing associated with obtaining cement, sinter for road construction or lime (depending on the needs of the market). According to classical method on 1 ton of 100% sulfuric acid and 1 ton port lancement spent 2.05 ton hosphogypsum (in terms of dry dihydrate).
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Pollock, Bruce E., Michael J. Link, Scott L. Stafford, Yolanda I. Garces, and Robert L. Foote. "Stereotactic Radiosurgery for Arteriovenous Malformations." Neurosurgery 78, no. 4 (October 30, 2015): 499–509. http://dx.doi.org/10.1227/neu.0000000000001085.
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Abstract BACKGROUND: Stereotactic radiosurgery (SRS) has been performed on patients with cerebral arteriovenous malformations (AVMs) for over 40 years. OBJECTIVE: To evaluate the impact of treatment period on obliteration, intracranial hemorrhage (ICH), and radiation-induced complications (RICs). METHODS: Retrospective comparison of 381 AVM patients having SRS during a 20-year period (group 1, January 1990 through March 1997, n = 160; group 2, April 1997 through December 2009, n = 221). The median radiological and clinical follow-up after initial SRS was 77 months and 93 months, respectively. RESULTS: Obliteration was 59.1% at 4 years and 85.1% at 8 years. Obliteration was more common in patients with hemispheric or cerebellar AVMs (P = .001), smaller prescription isodose volume (PIV) (P < .001), and group 1 patients (P < .001). The ICH rate was 7.7% at 4 years and 10.6% at 8 years. ICH was more common in older patients (P = .02), patients with deep AVM (P = .01), and larger PIV (P < .001). There was no difference in the ICH rate between the treatment groups (P = .18). The rate of permanent RICs was 4.4% at 4 years and 8.6% at 8 years. RICs were more common with larger PIVs (P < .001) and group 1 patients (P = .02). There was no difference in the number of patients having obliteration without new deficits between the 2 treatment periods (68.8% vs 73.3%, P = .33). CONCLUSION: Advances in SRS procedures over the past 20 years have resulted in a lower risk of RIC, but fewer patients had AVM obliteration. Increasing the prescription dose for patients with medium- and large-volume AVMs by using current conformal dose-planning techniques may improve the obliteration rate while maintaining a low risk of RICs.
Book chapters on the topic "004.77 004.896"
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Visscher, K. J., H. Bergström, V. Sundström, C. N. Hunter, and R. Van Grondelle. "Temperature Dependence of energy transfer from the long wavelength antenna BChl-896 to the reaction center in Rhodospirillum Rubrum, Rhodobacter Sphaeroides (w.t. and M21 mutant) from 77 to 177 K, studied by picosecond absorption spectroscopy." In Current Research in Photosynthesis, 1113–16. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0511-5_258.
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"Sonic Experiments." In Cornell '77, 35–60. Cornell University Press, 2017. http://dx.doi.org/10.7591/9781501712579-004.
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"Titel 2. Streitgenossenschaft." In §§ 50-77, 145–89. De Gruyter, 2017. http://dx.doi.org/10.1515/9783110248371-004.
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Becker, Richard C., and Frederick A. Spencer. "Facilitated Percutaneous Coronary Intervention." In Fibrinolytic and Antithrombotic Therapy. Oxford University Press, 2006. http://dx.doi.org/10.1093/oso/9780195155648.003.0018.
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The failure of fibrinolytic therapy to restore physiologic myocardial perfusion in upward of 40% of patients supports the development of strategies to improve response rates to percutaneous coronary intervention (PCI) in those requiring early procedures. The construct of facilitated PCI (pharmacoinvasive therapy) provides a platform for utilizing the strengths of existing therapies and treatment modalities. The Heparin in Early Patency (HEAP) trial (Zijlstra et al., 2002) included 1,702 patients treated with primary PCI for myocardial infarction (MI); 860 patients received aspirin (500 mg IV) and UFH (≥5,000 U IV) before being transported to the hospital and 842 patients received the same antithrombotic therapy in the hospital. TIMI 2 or 3 flow rates were higher in the pretreated group (31% vs. 20%; p = .001), and patients with TIMI 2 or 3 flow initially had a higher PCI success rate (94% vs. 89%; p <.001) and a lower 30-day mortality (1.6% vs. 3.4%; p = .04). The Plasminogen Activator Angioplasty Compatibility Trial (PACT) randomized 606 patients to receive a 50-mg bolus of alteplase or placebo, followed by immediate angiography and angioplasty if needed (Ross et al., 1999). TIMI flow rates on arrival to the catheterization laboratory were 33% and 15%, respectively. Facilitated PCI and primary PCI restored TIMI 3 flow in occluded vessels equally (77% and 79%, respectively). There were no differences in major bleeding. Left ventricular ejection fraction was highest in those with TIMI 3 flow on arrival to the catheterization laboratory or following PCI within 1 hour of alteplase administration. Full-dose fibrinolytic therapy with alteplase or reteplase followed by coronary angiography and PCI (if no clinical evidence of reperfusion) was evaluated retrospectively in the Global Use of Strategies to Open Occluded Arteries (GUSTO) III trial (Miller et al., 1999). Among those undergoing PCI (n = 392), 87 patients received in-laboratory abciximab. A trend toward reduced mortality was observed in abciximab-treated patients, but at a higher cost of hemorrhagic complications. In the Strategies for Patency Enhancement in the Emergency Department (SPEED) trial (Herrmann et al., 2000), 323 patients who underwent PCI had an 88% procedural success rate and a 30-day composite of death, reinfarction, or revascularization of 5.6%.
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"2. Being and Time, Sections 72-77." In Historical Destiny and National Socialism in Heidegger’s Being and Time, 29–67. University of California Press, 1999. http://dx.doi.org/10.1525/9780520919594-004.
Full textConference papers on the topic "004.77 004.896"
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Gillmer, Thomas C. "The Design and Construction of the Second Pride of Baltimore." In SNAME 9th Chesapeake Sailing Yacht Symposium. SNAME, 1989. http://dx.doi.org/10.5957/csys-1989-004.
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The PRIDE of Baltimore II was ordered to be built as a result of the tragic loss of her predecessor. She is not, however, a simple replacement. The purpose is, of course, to continue and extend the mission so successfully advanced during the more than nine years of nearly continuous sailing commission of "PRIDE I". This program is at the core of her design. She is, in configuration, sailplan, and material, a traditional fore-topsail schooner, typical of those built in Baltimore early in the 19th Century. She is very much in appearance like the first vessel, built 1976-77, which she replaces. Her design and structure, however, are considerably more advanced. Using contemporary techniques and tools in both design and construction she is, we believe, one of the finest wooden schooners of this size to be built. It is the purpose of this paper to describe some of the design and construction features that make this vessel unique.
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Пожарська, А. О. Ю. "Конфліктність як принцип музичної драматургії у фільмі «Володар перснів»." In CULTURAL STUDIES AND ART CRITICISM: THINGS IN COMMON AND DEVELOPMENT PROSPECTS. Baltija Publishing, 2020. http://dx.doi.org/10.30525/978-9934-26-004-9-77.
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