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Journal articles on the topic "004.021, 004.052.2"
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Burmistrova, A. L., M. N. Vavilov, D. S. Stashkevich, and T. A. Suslova. "Immunogenetic profile of MIC (A, B) HLA loci linked to MHC antigenic complex in Russians of the Chelyabinsk Region." Medical Immunology (Russia) 24, no. 1 (March 10, 2022): 41–52. http://dx.doi.org/10.15789/1563-0625-ipo-2324.
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The MIC genes are located on chromosome 6 in the class I major histocompatibility complex (MHC) region and encode a membrane-bound stress-inducible protein that acts as a ligand to stimulate the NKG2D activating receptor expressed on the surface of the most natural killer cells (NK). Currently, 7 MIC loci are known, of which only MICA and MICB encode proteins and show a significant allelic polymorphism. The MIC gene polymorphism and their location in the HLA region suggests presence of some ethnic and populational differences for the gene frequencies, linkage disequilibrium of distinct loci, and distribution of HLA-MIC haplotypes, thus making it possible to get information on genetic relationship of human populations. The aim of our study was to assess immunogenetic profile of Russian population in Chelyabinsk Region based on the non-classical HLA loci, i.e., MICA and MICB, in the context of worldwide population data. Methods of the study included immunogenetic typing of 100 donors identifying themselves as Russians, taken from the Registry of Stem Cell Donors at the Chelyabinsk Regional Blood Transfusion Station. The 2 loci (MICA and MICB) were typed at basic resolution, using PCR technique with sequence-specific primers (SSP-PCR). Gene frequencies (GF) were calculated using programs for immunogenetic research (Arlequin 3.5).Among Russian population from Chelyabinsk Region, the following characteristics of the MICA gene distributions were found: MICA *008, *002, *010, *009, frequency of > 7%; average frequencies, for MICA *004, *007, *018, *017; whereas MICA *027, *011, *006, *009:02, *049, *012, *016 was registered at a frequency of < 3.5%. MICB gene profile was as follows: MICB *005:02, *004, *002, *008 at a frequency of > 6%; at a frequency of 4% MICB *003, *005:03; MICB *005:01, * 005:04, * 009N, MICB *013, *014 at a frequency of0.5%. As based on calculated genetic distances (according to Ney) for the MICA locus, the dendrogram and scatter plot were designed by means of multidimensional scaling (MDS) method, presenting location of 30 world populations, including data on Russians in Chelyabinsk Region. The smallest genetic distances between the population of Russians from Chelyabinsk Region and other world populations were found between the population of Slovenia, as well as the USA population of European origin. As based on scatterplot obtained by the MDS approach for MICA gene frequencies, using the data of cluster analysis, we have found that the population of Russians from Chelyabinsk Region belongs to a cluster of typical European populations.The obtained patterns could be used for practical purposes to create a registry of stem cell donors in Russia. In addition, the data may be used as a control group for further research in the area of HLA-disease association, and could be also demanded by the specialists in population ethnogenesis.
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Lam, Patrick, Lisa Hackett, George AC Murrell, and Wai Weng Yeo. "Paper 04: The Effects of Glenohumeral Osteoarthritis on Early Clinical Outcomes Following Arthroscopic Rotator Cuff Repair." Orthopaedic Journal of Sports Medicine 10, no. 5_suppl3 (May 1, 2022): 2325967121S0054. http://dx.doi.org/10.1177/2325967121s00542.
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Objectives: It is unclear if concomitant glenohumeral osteoarthritis is protective or detrimental with respect to rotator cuff integrity after arthroscopic repair surgery. We hypothesized that the associated stiffness might protect the repaired tendon. In the alternate, arthritis might reflect a gradual degeneration of the joint including a degenerative tendon and therefore predispose the repair to re-tear. Therefore, the purpose of this study was to investigate whether concomitant osteoarthritic changes found intra-operatively during arthroscopic rotator cuff repairs (RCR) have a beneficial or detrimental effect on post-operative repair integrity. Methods: This study is a post-hoc analysis of prospectively collected data of patients who underwent primary arthroscopic RCR between 2005 and 2019 by a single surgeon. Patients were divided into an osteoarthritic group and a control group based on the presence or absence of intra- operative osteoarthritic changes respectively. The primary outcome measure was cuff integrity detected by post-operative ultrasound at 6-months. The secondary outcomes were patient-reported outcomes including shoulder pain, stiffness, level of activity at work and level of sport, and physician-reported outcomes including shoulder range of motion and strength. Results: A total of 2155 consecutive patients met the inclusion criteria with a mean age of 59 years (SD=0.2) and there were more males as compared to females (56% vs. 44%). 28% of patients undergoing RCR had osteoarthritic changes detected intra- operatively. Intra-operatively, the osteoarthritic group had more full-thickness tears (64% vs. 59%) (p<.001), a larger mean anteroposterior tear length [20mm (SD=0.5) vs. 17mm (SD=0.4)] (p<.001) and a larger mean mediolateral tear length [17mm (SD=0.5) vs. 15mm (SD=0.4)] (p<.001). Ultrasonographic evaluation at 6-months post-surgery demonstrated that the osteoarthritic group had a higher incidence of cuff re-tear rate as compared to the control group (15% vs. 11%) (p=.016) ( Figure 1). However, after performing a multiple logistic regression analysis, osteoarthritis was not found to be an independent predictor of re-tear. There were very marginal differences in patient-reported outcomes at 6-months after surgery between the two groups ( Table 1). The osteoarthritic group reported lesser post-operative frequency of activity pain [2.0 (SD=1.46) vs. 2.2 (SD=1.43)] (p=.005), frequency of extreme pain [0.8 (SD=1.35) vs. 1.0 (SD=1.41)] (p=.035) and level of pain during overhead activity [1.7 (SD=1.30) vs. 1.9 (SD=1.30)] (p=.021) as compared to controls. As compared to controls, the osteoarthritic group also experienced lesser post-operative stiffness [1.5 (SD=1.32) vs. 1.6 (SD=1.31)] (p=.019) and reported lower intensities of work-related activities [1.1 (SD=0.88) vs. 1.2 (SD=0.85)] (p=.038) and lower level of sport activity [0.4 (SD=0.62) vs. 0.5 (SD=0.70)] (p=.004). In terms of physical examination at 6-months following surgery ( Table 2), the osteoarthritic group were found to have lesser range of motion in forward flexion [146° (SD=33.1) vs. 151° (SD=31.2)] (p=.009), abduction [127° (SD=38.8) vs. 131° (SD=38.1)] (p=.034), external rotation [50° (SD=21.4) vs. 52° (SD=21.0)] (p=.024) and internal rotation (L1 vertebrae (SD=4.2) vs. T12 vertebrae (SD=4.2)] (p=.004) as compared to controls. The osteoarthritic group as weaker internal rotation strength [68N (SD=30.5) vs. 73N (SD=32.9)] (p=.004), external rotation strength [57N (SD=25.3) vs. 60N (SD=27.2)] (p=.026), supraspinatus flexion strength [45N (SD=26.8) vs. 50N (SD=27.9)] (p<.001), lift-off [40N (SD=24.3) vs. 44N (SD=25.3)] (p<.001) and adduction strength [76N (SD=36.5) vs. 81N (SD=39.3)] (p=.008) as compared to the control group. Conclusions: Patients with concomitant glenohumeral osteoarthritis who underwent arthroscopic RCR had higher re-tear rates at 6-months after surgery. However, osteoarthritis is not an independent predictor of rotator cuff re-tear at 6-months. Therefore, arthroscopic RCR is a viable surgical option for these patients. [Figure: see text][Table: see text][Table: see text]
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ARCHIMÈDE, H., C. PONCET, M. BOVAL, F. NIPEAU, L. PHILIBERT, A. XANDÉ, and G. AUMONT. "Comparison of fresh and dried Digitaria decumbens grass intake and digestion by Black-belly rams." Journal of Agricultural Science 133, no. 2 (September 1999): 235–40. http://dx.doi.org/10.1017/s0021859699006784.
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The intake and digestion of fresh and dried Digitaria decumbens grass by rams was compared using a 2×2 factorial design. The experiment took place in Guadeloupe (French West Indies) in 1996. Eight rams (mean liveweight: 45·7±3·1 kg) were maintained in metabolism cages. Digitaria decumbens grass was cut daily and distributed to four of them, the other four were fed the following day with the equivalent forage which had meanwhile been dried for 20 h at 60°C. Chemical composition (g/kg of dry matter (DM)) of the two diets based on neutral detergent fibre (NDF, 713, S.E. 18), acid detergent fibre (ADF, 361, S.E. 13) and crude protein (CP, 90, S.E. 4) was similar. The DM intake (61·0 and 53·2 g/W0·75, S.E. 2·0, P<0·05), the NDF (0·753 and 0·727, S.E. 0·004, P<0·011) and CP (0·588 and 0·544, S.E. 0·014, P<0·09) total tract digestibility of fresh and dried herbage were different. Nylon bag estimates of effective DM degradability and fractional degradation rates (per h) in the rumen were 0·436, 0·414 (S.E. 0·005, P<0·004) and 0·048, 0·038 (S.E. 0·002, P<0·02) for fresh and dried grass, respectively. Rumen digestibility of organic matter and NDF were 0·516, 0·541 (S.E. 0·021) and 0·763, 0·692 (S.E. 0·019), respectively. The rumen turnover rates of particles (per h) were 0·024 and 0·015 (S.E. 0·001, P<0·05) for fresh and dried forage respectively. The efficiency of microbial protein synthesis (g microbial nitrogen/kg organic matter apparently degraded in the rumen) was similar with the two diets : 33·5 and 33·0 (S.E. 3·3, P<0·9) for fresh and dried forage respectively. In conclusion, fresh Digitaria decumbens was nutritionally superior to dried. This is probably due to a faster degradation rate and a lower rumen retention time of the fresh forage.
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Tsimberidou, A. M., C. Tam, W. Wierda, S. O' Brien, S. Lerner, and M. J. Keating. "Beta-2 microglobulin (B2M) is an independent prognostic factor for clinical outcomes in patients with CLL treated with frontline fludarabine, cyclophosphamide, and rituximab (FCR) regardless of age, creatinine clearance (CrCl)." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 7034. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.7034.
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7034 Introduction: High β2M levels are a risk factor in CLL. PCR therapy has been reported to be better tolerated than FCR in older or with decrease renal function pts (Shanafelt, Blood 108:15a). We assessed the association between age, CrCl, PS, β2M and outcomes in pts treated with FCR. Methods: From 7/99 to 1/04, 300 pts received rituximab 375 mg/m2 D1; fludarabine 25 mg/m2/d D2–3; and cyclophosphamide 250 mg/m2/d D2–3. Serum β2M levels were measured by radioimmunoassay. CrCl was calculated (Cockcroft-Gault equation). Results: The median age was 57 yrs (≥70, 14%). Age ≥70 was associated with fewer FCR courses (p<.0001); lower rates of CR (p=.001), overall response (OR; p=.04), survival (OS; p<.0001), and FFS (p=.008); and higher rates of G3–4 thrombopenia (p<.0001) or anemia (p=.002) compared with age<70. The median CrCl was 90 mL/min (CrCl <70, 27%). Pts with CrCl <70 had higher rates of G3–4 thrombopenia (p=.006) or anemia (p=.01) than others. There were no differences between the 2 groups in the other outcomes. PS was 0 in 40%, 1 in 57%, and 2 in 3% of pts. Better PS was associated with higher rates of CR (p=.007) and FFS (p=.02) but did not affect OR or OS. The median β2M level was 3.7 mg/L (β2M ≥ 4, 43%). The rates of CR, survival, and FFS were lower in pts with β2M ≥ 4 compared with others (p<.0001 each). High β2M levels were associated with older age, lower CrCl levels, poorer PS (p<.0001 each), higher rates of G3–4 neutropenia (p=.005), thrombocytopenia (p=.01), and infections (p=.03), and fewer FCR courses (p=.004). The median follow-up was 5 yrs. The rates of CR, 3-yr OS and 3-yr FFS were 72%, 87% and 76%, respectively. Independent factors predicting response were lower β2M (p=.0004) and lower WBC counts (p=.02). Independent factors predicting longer OS were younger age (p=.001), lower β2M (p=.003) and lower WBC (p=.03). Independent factors predicting longer FFS were lower β2M levels (p=.0006), and lower WBC counts (p=.005). Conclusion: Age ≥70 yrs and poor PS, but not CrCl level were associated with poor clinical outcomes. High β2M levels are an independent adverse prognostic factor for CR, OS, and FFS in the context of other prognostic factors. No significant financial relationships to disclose.
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Farinha, Pedro, Abdulwahab Al-Tourah, Karamjit Gill, Richard Klasa, Joseph M. Connors, and Randy D. Gascoyne. "The architectural pattern of FOXP3-positive T cells in follicular lymphoma is an independent predictor of survival and histologic transformation." Blood 115, no. 2 (January 14, 2010): 289–95. http://dx.doi.org/10.1182/blood-2009-07-235598.
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Abstract Previous studies of follicular lymphoma (FL) patients treated heterogeneously have suggested that decreased numbers of regulatory T cells correlates with improved survival. We studied advanced-stage FL patients from a single institution phase 2 trial. All patients were treated uniformly with multiagent chemotherapy and radiation. Tissue microarrays were constructed using diagnostic biopsies available in 105 patients and stained with CD4, CD8, CD25, and forkhead/winged helix transcription factor 3 (FOXP3) antibodies. Both cell content and cell distribution were evaluated. For all antibodies, there were cases with a predominant intrafollicular or perifollicular localization of cells (follicular pattern) while others displayed a diffuse pattern. The median follow-up of living patients was 17.1 years. The International Prognostic Index score predicted overall survival (OS; P = .004) but not risk of transformation (RT). Cell content did not impact survival, while immunoarchitectural patterns of CD4/CD8 were significant for progression-free survival (PFS; P = .056), CD25 for both PFS and OS (P = .002 and P = .024, respectively), and FOXP3+ predicted PFS, OS, and RT (P = .001, P < .001 and p = .002, respectively). A Cox multivariate model showed both International Prognostic Index score and FOXP3+ pattern were independent predictors of OS (P = .008 and P < .001, respectively), while only FOXP3+ pattern predicted RT (P = .004). We conclude that FOXP3+ cell distribution significantly predicts survival and RT in FL.
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Rentería-Mexía, Ana, Sonia Vega-López, Micah L. Olson, Pamela D. Swan, Chong D. Lee, Allison N. Williams, and Gabriel Q. Shaibi. "Effects of a lifestyle intervention on markers of cardiometabolic risk and oxidized lipoproteins among obese adolescents with prediabetes." Public Health Nutrition 22, no. 4 (December 27, 2018): 706–13. http://dx.doi.org/10.1017/s1368980018003476.
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AbstractObjectiveObesity and hyperglycaemia contribute to the atherosclerotic process in part through oxidative modifications to lipoprotein particles. The present study aimed to evaluate the effects of a lifestyle intervention on markers of oxidized lipoproteins in obese Latino adolescents with prediabetes.DesignPre–post design.SettingParticipants were enrolled into a 12-week lifestyle intervention. Measurements pre- and post-intervention included anthropometrics and body composition, lipid panel, oxidized LDL (oxLDL), oxidized HDL (oxHDL), intake of fresh fruits and vegetables, and cardiorespiratory fitness.ParticipantsThirty-five obese Latino adolescents (seventeen females, eighteen males; mean age 15·5 (sd1·0) years; mean BMI percentile 98·5 (sd1·2)) with prediabetes.ResultsIntervention participation resulted in significant reductions in weight (−1·2 %,P= 0·042), BMI and BMI percentile (−2·0 and −0·4 %, respectively,P< 0·001), body fat (−7·0 %,P= 0·025), TAG (−11·8 %,P= 0·032), total cholesterol (−5·0 %,P= 0·002), VLDL-cholesterol (−12·5 %,P= 0·029), and non-HDL-cholesterol (−6·7 %,P= 0·007). Additionally, fitness (6·4 %,P< 0·001) and intake of fruits and vegetables (42·4 %,P= 0·025) increased significantly. OxLDL decreased significantly after the intervention (51·0 (sd14·0)v. 48·7 (sd12·8) U/l,P= 0·022), while oxHDL trended towards a significant increase (395·2 (sd94·6)v. 416·1 (sd98·4) ng/ml,P= 0·056).ConclusionsThese data support the utility of lifestyle intervention to improve the atherogenic phenotype of Latino adolescents who are at high risk for developing premature CVD and type 2 diabetes.
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Papasideris, Mia, Scott T. Leatherdale, Kate Battista, and Peter A. Hall. "An examination of the prospective association between physical activity and academic achievement in youth at the population level." PLOS ONE 16, no. 6 (June 11, 2021): e0253142. http://dx.doi.org/10.1371/journal.pone.0253142.
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Exercise has significant benefits for brain health and this may have downstream learning benefits for youth. However existing studies looking at links between physical activity and academic achievement are limited by relatively small sample sizes and/or cross-sectional designs. The objective of this study is to determine the direction and magnitude of the association between physical activity and academic achievement in a large prospective sample of adolescents. Linear mixed models with random intercepts and multinomial ordinal generalized estimating equations were employed to analyze the prospective relationship between measures of physical activity and academic achievement from the COMPASS study (N = 9,898 linked participant data cases from year 2 (2013–2014) to year 4 (2015–2016)). The linear relationships between minutes of moderate to vigorous physical activity and academic achievement (English: r = -.047, p < .000; Math: r = -.026, p = .008) as well as meeting the national physical activity guidelines and academic achievement (English: est = -.052, p = .004; Math: est = -.052, p = .028) were negative and trivial in magnitude. Organized sport participation showed slight positive associations with academic achievement indices, but these were also of trivial magnitude. In conclusion, the relationship between physical activity and academic achievement was effectively null in this population sample. Advocacy for physical activity programming for adolescent populations may best be undertaken with reference to lack of net academic achievement cost, rather than presence of benefit, or simply with reference to the many other physical and mental health benefits for youth.
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Loughlin, Howard H., Nancy E. Clapp-Channing, Stephen H. Gehlbach, John C. Pollard, and Thomas M. McCutchen. "Early Termination of Breast-Feeding: Identifying Those at Risk." Pediatrics 75, no. 3 (March 1, 1985): 508–13. http://dx.doi.org/10.1542/peds.75.3.508.
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In a private pediatric practice, 94 infants who were breast-feeding were followed for the first 2 months of life in order to define the frequency of cessation of breast-feeding and to identify factors that would predict mothers and infants at risk for early cessation. At 8 weeks, 30% of the mothers had stopped nursing. Factors associated with cessation were: maternal lack of confidence in breast-feeding (P < .001); anticipated duration of nursing less than 6 months (P = .002); ratings by the nursery staff of infant's excessive crying (P = .007), infant's demanding personality (P = .007), trouble with féeding (P = .001), and future trouble with feeding (P = .004). Together, these factors predicted 77% of the mothers who terminated breast-feeding. Supplementing with formula before the 2-week office visit also led to termination of breast-feeding by 8 weeks (P = .006). This decision was frequently made without medical advice. Nearly 64% (14/22) of the mothers who added formula within the first 2 weeks did so without contacting the pediatric practice.
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Andrews, Natalie, Abraham Ettaher, Robert Scissons, and David Paolini. "Prevalence of Hemodynamically Significant Internal Carotid Artery Disease Based on the Signs of the Zodiac." Journal for Vascular Ultrasound 42, no. 3 (August 24, 2018): 120–22. http://dx.doi.org/10.1177/1544316718795264.
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Vascular sonography requires a basic understanding of statistical concepts used to evaluate exam efficacy. Statistical analysis, however, is often viewed as intimidating and dull. To make this subject less threatening and more interesting, our vascular ultrasound class investigated the prevalence of hemodynamically significant internal carotid artery (ICA) disease based on signs of the zodiac. Randomly selected carotid ultrasound patients were obtained from an accredited vascular laboratory database based on month and day of birth. Each sign of the zodiac was assigned 60 patients. Exam results were defined as (1) normal: bilateral < 50% ICA stenoses, or (2) abnormal: unilateral or bilateral ⩾ 50% ICA stenosis. The Fisher exact test was used to compare normal and abnormal patient groups within each sign of the zodiac. The P value of < .05 was used to define statistical significance. A total of 720 patients were included in this analysis. Patients born under the sign of Gemini had significantly fewer numbers of abnormal stenoses than 6 astrological groups: Capricorn ( P = .004), Virgo ( P = .014), Libra ( P = .007), Pisces ( P = .026), Aries ( P = .000), and Sagittarius ( P = .007). Patients born under the sign of Aries had significantly greater numbers of abnormal results than 7 zodiacal groups: Taurus ( P = .001), Aquarius ( P = .002), Gemini ( P = .000), Pisces ( P = .040), Cancer ( P = .015), Scorpio ( P = .002), and Leo ( P = .022). Hemodynamically significant (⩾50%) ICA stenoses were statistically more prevalent for carotid duplex patients born under the zodiac sign of Aries and significantly less prevalent under the sign of Gemini. While these results may be medically unimportant, this vascular ultrasound assignment helps students understand the value of statistical reporting and, in general, made statistical analysis more relatable and enjoyable.
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Bivoltsis, Alexia, Gina Trapp, Matthew Knuiman, Paula Hooper, and Gina Leslie Ambrosini. "The influence of the local food environment on diet following residential relocation: longitudinal results from RESIDential Environments (RESIDE)." Public Health Nutrition 23, no. 12 (May 7, 2020): 2132–44. http://dx.doi.org/10.1017/s1368980019005111.
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AbstractObjective:To examine the associations of changes in the local food environment, individual behaviours and perceptions with changes in dietary intake, following relocation from an established neighbourhood to a new residential development.Design:Spatial food environment exposure measures were generated relative to each participant’s home address using the locations of food outlets at baseline (before moving house) and follow-up (1–2 years after relocation). Self-reported data on socio-demographics, self-selection, usual dietary intake, individual behaviours and perceptions of the local food environment were sourced from the RESIDential Environments (RESIDE) Project. Changes in spatial exposure measures, individual behaviours and perceptions with changes in dietary outcomes were examined using mixed linear models.Setting:Perth, Western Australia, 2003–2007.Participants:Adults (n 1200) from the RESIDE Project.Results:Moving to a new residential development with more convenience stores and café restaurants around the home was significantly associated with an increase in unhealthy food intake (β = 0·049, 95 % CI 0·010, 0·089; β = 0·020, 95 % CI 0·007, 0·033) and was partially mediated by individual behaviours and perceptions. A greater percentage of healthy food outlets around the home following relocation was significantly associated with an increase in healthy food (β = 0·003, 95 % CI 0·001, 0·005) and fruit/vegetable intake (β = 0·002, 95 % CI 0·001, 0·004).Conclusions:Policy and planning may influence dietary intakes by restricting the number of convenience stores and other unhealthy food outlets and increasing the relative percentage of healthy food outlets.
Dissertations / Theses on the topic "004.021, 004.052.2"
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Marlow, Gregory. "Week 00, Video 02: Maya Download and Install." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/digital-animation-videos-oer/2.
Full textBooks on the topic "004.021, 004.052.2"
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Marquart, Mike J. Tining versus carpet dragging for texturing PCC pavements: IM-1-094(012)100, IM-5-094(018)059, IM-2-094(049)248, IM-2-094(043)289, & IM-8-029(016)044 : construction report. Bismarck, N.D: North Dakota Dept. of Transportation, Materials and Research Division, 2000.
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Agung, Indonesia Mahkamah. Keputusan bersama Ketua Mahkamah Agung RI dan Menteri Agama RI nomor KMA/001/SK/I/1983 dan nomor 1 tahun 1983, nomor KMA/002/SK/I/1983 dan nomor 2 tahun 1983, nomor KMA/003/SK/I/1983 dan nomor 3 tahun 1983, nomor KMA/004/SK/I/1983 dan nomor 4 tahun 1983, dan Peraturan Menteri Agama RI nomor 1 tahun 1983 Tentang Pemberi Bantuan Hukum pada Peradilan Agama. [Jakarta]: Departemen Agama RI, Ditjen Binbaga Islam, Ditbinbapera Islam, 1989.
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Never Have I Ever. New York: Harperteen an imprint of HarperCollinsPublishers, 2012.
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050-001-00326-1, S/N. Highway Statistics, 1989/Stk No. 050-001-00311-2 (Highway Statistics). United States Government Printing, 1990.
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United States Government Structure: An English as a Second Language Text (027-002-00380-2). United States Government Printing, 1989.
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Qureshi, Norman, and Kim Rajappan. Sudden cardiac death. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0120.
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Sudden cardiac death (SCD) is defined as unexpected death due to a cardiac disease, in a patient with or without known cardiac disease and which occurs within 1 hour from the appearance of the first clinical symptoms. The sudden cessation of cardiac activity leads to haemodynamic collapse, typically due to sustained ventricular tachyarrhythmias. The event is described as an aborted SCD (or sudden cardiac arrest) when an intervention (e.g. defibrillation) or spontaneous reversion restores circulation. The lack of uniformity with this definition complicates SCD statistics. By convention, the use of SCD to describe both fatal and non-fatal cardiac arrests persists. SCD continues to be a leading cause of death in Western countries, and accounts for 15%–20% of all natural deaths in adults in the US and Western Europe, and up to 50% of all cardiovascular deaths. In the US, estimates of SCDs from retrospective death certificate analyses range from 300 000 to 350 000 annually, giving an incidence of 0.1%–0.2% per year amongst the population above the age of 35 years. Event rates are said to be similar in Europe, although worldwide incidence is difficult to estimate and varies in accordance to the prevalence of CHD. The incidence of SCD increases with age and underlying cardiac disease. There is also a male preponderance, with men 2–3 times more likely to experience SCD than women, and this reflects the higher incidence of CHD in men.
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Lopez de Ramos, Aura L., and Erick Ramos Sanchez. UNICyTios UNICyT incubator of startup - Vol. 2. Universidad Internacional de Ciencia y Tecnología, 2022. http://dx.doi.org/10.47300/978-9962-738-02-2.
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Esta publicación electrónica recoge los proyectos realizados por estudiantes de Licenciatura que ofrece la Universidad Internacional de Ciencia y Tecnología (UNICyT) durante el periodo académico 03-2020. Estos modelos de negocio son el producto de las ideas innovadoras propuestas por los estudiantes en el curso Design Thinking, Startup y Lean Canvas, y tienen como principal objetivo, la inserción de nuestros estudiantes al mundo del emprendimiento y la innovación. Todos estos trabajos fueron presentados previamente por los estudiantes en Ferias de Emprendimiento que la UNICyT organiza y que forman parte de las actividades de extensión orientadas al fortalecimiento de capacidades para el emprendimiento de los estudiantes de licenciatura de la UNICyT. Se estimula a los estudiantes desde el curso de Design Thinking, Startup y Lean Canvas a desarrollar ideas innovadoras. El proceso culmina con las presentaciones de los estudiantes a los miembros de la comunidad universitaria en un formato de ferias que la universidad ha denominado UNICyT Incubator of Startups - UNICyTios. Adicionalmente a la presentación oral en modo PechaKucha, todos los participantes presentan un manuscrito que cumple la normativa exigida en el curso, 30 de ellos están publicados en este e-book. La necesidad de diseñar y desarrollar modelos de negocios que respondan a una dinámica de mercado en la que convergen productos, servicios, experiencias y significados, y a una dinámica social que privilegia a la persona por sobre las organizaciones, ha dado lugar a nuevos enfoques teóricos y metodológicos. En este sentido, el programa se ha propuesto la aplicación de la metodología de Design Thinking, Startup y Lean Canvas para la creación de una empresa novedosa en un espacio de capacitación, reflexión y aprendizaje a través de la combinación de conocimiento, práctica y exploración en un proceso participativo. El programa combina la documentación y formación conceptual con talleres y workshops que tienen como objetivo dominar la praxis de las técnicas de Design Thinking, Startup y Lean Canvas aplicadas a la Innovación. Los 30 modelos de negocio publicados en esta edición recogen los resultados del curso Design Thinking, Startup y Lean Canvas realizado por 30 estudiantes que aplicaron los conocimientos adquiridos durante su formación en la carrera y en el curso CE 011 001 Design Thinking, Startup y Lean Canvas sobre la metodología basada en una comunicación interactiva multilateral y participativa, como parte de la solución de los problemas de las comunidades.
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Сверхтвердые материалы. Получение и применение. Vol. 4, Инструменты и технологические процессы в прецизионной финишной обработке / В.В. Рогов, Ю.Д. Филатов, Г.Г. Добровольский [и др.] ; под ред. В.В. Рогова. Киев: [б. и.], 2006.
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Oliveira, Mário Cézar Amorim de, Nilson de Souza Cardoso, and Jaqueline Rabelo de Lima. Itinerários de resistência: pluralidade e laicidade no Ensino de Ciências e Biologia. Editora Realize, 2021. http://dx.doi.org/10.46943/viii.enebio.2021.01.000.
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Você tem em mãos o e-book com os Anais do ENEBIOnLine, a edição totalmente à distância (ou remota, ou virtual, ou on-line, como queira! rs) do VIII Encontro Nacional de Ensino de Biologia (VIII ENEBIO), do VIII Encontro de Ensino de Biologia da Regional Nordeste (VIII EREBIO-NE) e do II Simpósio Cearense de Ensino de Biologia (II SCEB). Uma edição histórica, em vários sentidos: 1. A primeira edição completamente não presencial dos nossos encontros de Ensino de Biologia; 2. A primeira edição organizada e realizada durante uma pandemia de grandes proporções que causa (ainda, infelizmente) uma crise sanitária sem precedentes na história mundial; e 3. Uma edição que tem “história pra contar”, exatamente em virtude desses contextos. Em 2018, no VII Encontro Nacional de Ensino de Biologia (VII ENEBIO) e I Encontro Regional de Ensino de Biologia (I EREBIO-NORTE), estávamos muito animados em trazer de volta para o Nordeste esse evento que bianualmente congrega nossa comunidade sbenbiana e tem o papel fundamental de dar continuidade e ampliar as ações da SBEnBio, promovendo interações de profissionais que atuam em diversos níveis e ambientes educativos no ensino de Ciências e de Biologia. Além disso, pensávamos em consolidar o EREBIO-NE como um importante espaço acadêmico-científico de troca e aprendizados entre professores e pesquisadores da região. Esses encontros congregam pesquisadores dos campos do Ensino de Ciências e Biologia, professores do ensino superior e da educação básica, além de estudantes das Licenciaturas em Ciências Biológicas e afins, alcançando quatro importantes segmentos de investimento na educação científica de qualidade. Empolgados com a expressiva participação numérica alcançada nos encontros nacionais anteriores e com a possibilidade de mitigar a carência de eventos dessa natureza e magnitude na região nordeste, em 2019 submetemos três propostas de tema gerador a uma enquete pública nas redes sociais. O tema gerador escolhido para o VIII ENEBIO, VIII EREBIO-NE e II SCEB, foi Itinerários de Resistência: Pluralidade e Laicidade no Ensino de Ciências e Biologia. Um tema que nos possibilitaria propor debates sobre questões pertinentes ao contexto social, político e educacional que o país atravessava e que acreditávamos que impactariam a formação inicial e continuada tanto quanto o trabalho de professores de Ciências e Biologia, tais como: as novas Diretrizes Curriculares Nacionais para a Formação Inicial de Professores, as recém aprovadas Base Nacional Comum Curricular para o Ensino Fundamental e para o Ensino Médio, além de questões sócio ambientais e culturais, educação para as relações étnico-raciais, educação no campo, educação indígena, relação entre conhecimento científico e conhecimentos de outras naturezas (religiosos, senso comum etc.), dentre tantas outras importantes questões. Nem imaginávamos que um vírus, que ironia, nos imporia mudanças... ainda no final de 2019 vimos nos noticiários o surto do SARS-CoV-2 na China... graças à nossa formação específica (em Ciências Biológicas) e à lembrança de situações anteriores, como a do surto da Síndrome Aguda Respiratória Grave (SARS) em 2002-2003, sabíamos que poderíamos estar diante não apenas de uma mera “gripezinha”, mas mantivemos os planos do evento que estava agendado para acontecer no período de 29 de Abril a 02 de Maio de 2020. Tínhamos um enorme interesse em promover o debate acerca das experiências dos professores e pesquisadores que atuam em diferentes espaços e níveis de escolaridade e refletir sobre como as características da pluralidade e laicidade necessárias a uma educação básica democrática e inclusiva, especialmente a educação científica, estavam, e ainda estão hoje, vulneráveis no contexto dos atuais projetos e políticas educacionais. Nesse contexto, debater conflitos, propor ações e compartilhar experiências eram os desafios que nos moviam a pensar itinerários de resistência que caminhassem na direção do fortalecimento da profissão docente e do ensino de Ciências e de Biologia. Com o aumento do número de casos de infecções na China e com sua disseminação pela Europa, nos acendeu o alerta para um eventual adiamento. Em março, o primeiro caso no Brasil é noticiado, mais tensão e mais apreensão. Tivemos uma primeira onda, da qual, para alguns especialistas, nunca saímos, decidimos, portanto, após as primeiras medidas de isolamento social, adiar a realização do Encontro para acontecer, ainda presencialmente, de 02 a 04 de setembro de 2020. Em 31 de maio, já somávamos mais de 29 mil vidas ceifadas no país pela COVID-19, em meio a negacionismos de todas as ordens que indicavam que o quadro provavelmente pioraria. Em junho de 2020, a Coordenação Organizadora Local, em concordância com a Diretoria Executiva Nacional (DEN) da SBEnBio e seu Conselho Deliberativo Nacional (CDN), comunicava o adiamento do evento por tempo indeterminado. Nesse momento, tínhamos indicativos de que poderíamos contar em breve com uma vacina, mas não havia prazo para que isso acontecesse. O Ceará e outros estados nordestinos estavam em lockdown, o país estava atônito frente à disseminação do vírus e ao negacionismo dos que deveriam estar lutando para combatê-lo. Final do ano de 2020, apesar de uma pequena queda do número de mortes no país e do anúncio de vacinas por laboratórios e institutos como o Butantan e a Fiocruz, as exitosas experiências de nossa parceira, Realize Eventos Científicos, na organização de eventos nacionais on-line, nos estimulou a retomar a organização do evento e considerar a possibilidade de sua realização nesse modelo. Seria uma aventura! Mas será que a vacinação não possibilitaria nos encontrarmos presencialmente, já em 2021? As estimativas não eram nada animadoras. Tudo indicava que o foco do governo federal seria o “tratamento precoce”, sabidamente ineficiente. Enfim, nos apegamos a experiência de nossa parceira e, em novembro de 2020, anunciamos o novo formato do evento, nascia o ENEBIOnLine! E foi contando com expressiva compreensão e apoio da comunidade sbenbiana que, mesmo que registrado descontentamentos, prevaleceu a decisão consciente ante a crise sanitária que ainda enfrentávamos no final de 2020 e início de 2021; e de 25 a 29 de janeiro aconteceu o VIII ENEBIO, VIII EREBIO-NE e o II SCEB, no formato totalmente on-line. Mantivemos praticamente a mesma programação, apesar do contexto da pandemia de COVID-19 e de suas implicações para a nossa área, como o impacto do ensino remoto na educação científica e formação docente, terem permeado inevitavelmente os debates nas palestras, mesas redondas e sessões de apresentação de trabalho. Podemos dizer que foi um “sucesso de público e de crítica”, com 909 credenciados participando das seis mesas redondas, palestras de abertura e encerramento, reunião ampliada da SBEnBio, painel temático reunindo as ex-presidentas e os ex-presidentes da associação... e tudo no conforto e na segurança de nossos lares. Uma decisão que já durante o evento se mostrava acertada, tendo em vista o recrudescimento da crise sanitária, com aumento alarmante do número de mortos (hoje, já somamos mais de 265.500 vidas perdidas para a COVID-19, segundo o último balanço do consórcio de veículos de imprensa), colapso da rede de atendimento hospitalar e que, possivelmente, será agravada em função da morosidade da vacinação no país associada ao “jeitinho brasileiro” de desobedecer as normas básicas de (auto)proteção contra a infecção. Apesar dos tempos terríveis que aparentemente ainda haveremos de enfrentar, esperamos que o reconhecimento pelo STF da perseguição jurídica sofrida pelo nosso ex-presidente da República... ops (desculpem-nos o ato falho! rs)... esperamos que a publicação desse e-book com os Anais do ENEBIOnLine, contendo a íntegra dos 632 trabalhos apresentados durante o evento, chegue como um sopro de esperança de que dias melhores virão! De que depois da peste e da tempestade, virá a bonança... de que, no segundo semestre de 2022, todes vocês poderão estar conosco em Fortaleza, Ceará, para o IX ENEBIO, IX EREBIO-NE e III SCEB... para sentir o calor da ‘Terra da Luz’ e do abraço que não pôde ser dado, para debater sobre o Ensino de Biologia, cada dia mais necessário no enfrentamento do negacionismo científico e das fake news que adoecem de morte o Brasil.
Book chapters on the topic "004.021, 004.052.2"
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Ziccardi Capaldo, Giuliana. "IV.2 Legal Maxims: Summaries and Extracts from Selected Case Law." In The Global Community Yearbook of International Law and Jurisprudence 2020, 641–66. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780197618721.003.0033.
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IV.2.1Situation in Darfur IV.2.1.1The Prosecutor v. Omar Hassan Ahmad Al-Bashir, Case No. ICC-02/05-01/09 OA2, Appeals Chamber, Judgment, 6 May 2019 IV.2.2Situation in the Democratic Republic of the Congo IV.2.2.1The Prosecutor v. Bosco Ntaganda, Case No. ICC-01/04-02/06, Trial Chamber VI, Judgment, 7 November 2019...
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"012 Checkliste Manipulation." In Manuelle Medizin 2, edited by Ulrich W. Böhni, Markus Lauper, and Hermann A. Locher. Stuttgart: Georg Thieme Verlag, 2012. http://dx.doi.org/10.1055/b-0034-33488.
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Taylor, Rachael W., Adell Cox, Lee Knight, Deirdre A. Brown, Kim Meredith-Jones, Jillian J. Haszard, Anna M. Dawson, Barry J. Taylor, and Sheila M. Williams. "A Tailored Family-Based Obesity Intervention: A Randomized Trial." In Obesity: Stigma, Trends, and Interventions, 127–35. American Academy of Pediatrics, 2018. http://dx.doi.org/10.1542/9781610022781-a_tailored.
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OBJECTIVE To determine whether a 2-year family-based intervention using frequent contact and limited expert involvement was effective in reducing excessive weight compared with usual care. METHODS Two hundred and six overweight and obese (BMI ≥85th percentile) children aged 4 to 8 years were randomized to usual care (UC) or tailored package (TP) sessions at university research rooms. UC families received personalized feedback and generalized advice regarding healthy lifestyles at baseline and 6 months. TP families attended a single multidisciplinary session to develop specific goals suitable for each family, then met with a mentor each month for 12 months, and every third month for another 12 months to discuss progress and provide support. Outcome measurements (anthropometry, questionnaires, dietary intake, accelerometry) were obtained at 0, 12, and 24 months. RESULTS BMI at 24 months was significantly lower in TP compared with UC children (difference, 95% confidence interval: −0.34, −0.65 to −0.02), as was BMI z score (−0.12, −0.20 to −0.04) and waist circumference (−1.5, −2.5 to −0.5 cm). TP children consumed more fruit and vegetables (P = .038) and fewer noncore foods (P = .020) than UC children, and fewer noncore foods were available in the home (P = .002). TP children were also more physically active (P = .035). No differences in parental feeding practices, parenting, quality of life, child sleep, or behavior were observed. CONCLUSIONS Frequent, low-dose support was effective for reducing excessive weight in predominantly mild to moderately overweight children over a 2-year period. Such initiatives could feasibly be incorporated into primary care.
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"012 Mobilisation mit Impuls MMI (Manipulation)." In Manuelle Medizin 2, edited by Ulrich W. Böhni, Markus Lauper, and Hermann A. Locher. Stuttgart: Georg Thieme Verlag, 2012. http://dx.doi.org/10.1055/b-0034-33487.
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"Régions Francophones réels Francophones occasionnels Population Nombre % Nombre % AFRIQUE 30 001 000 4,7 40 617 000 6,3 645 000 000 Afrique du Nord-Est 219 000 0,31 700 000 2 83 400 000 Maghreb 14 455 000 24,7 17 030 000 29 58 400 000 Afrique subsaharienne 13 477 000 3,3 19 745 000 4,8 489 140 000 OCÉAN INDIEN 1 850 000 13,2 2 142 000 15,2 14 060 000 AMÉRIQUE 8 682 000 1,23 565 000 0,5 714 000 000 Amérique du Nord 7 286 000 2,93 2000 000 1,3 247 806 000 Amérique centrale, Caraïbes 1 216 000 0,7 365 000 0,2 176 794 000 Amérique du Sud 180 000 0,06 289 4000 000 ASIE 1 627 000 0,05 810 000 0,03 3 060 000 000 Proche et Moyen-Orient 1 491 000 0,8 800 000 0,4 186 000 000 Extrême-Orient 136 000 0,005 10 000 0,0004 2 874 000 000 EUROPE 63 952 000 8,19 200 000 0,1 789 000 000 Europe de l’Ouest 62 872 000 17,5 5 200 000 1,4 360 000 000 Europe de l’Est et URSS 1 080 000 0,34 000 000 0,9 429 000 000 OCÉANIE 350 000 1,3 33 000 0,1 26 000 000 MONDE 104 612 2 54 225 000 1 5 234 000 000." In Francotheque: A resource for French studies, 219. Routledge, 2014. http://dx.doi.org/10.4324/978020378416-36.
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Palamar, Joseph J., Monica J. Barratt, Leigh Coney, and Silvia S. Martins. "Synthetic Cannabinoid Use Among High School Seniors." In Medical Risks of Marijuana, 24–32. American Academy of Pediatrics, 2017. http://dx.doi.org/10.1542/9781610022767-synthetic_cannabinoid.
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OBJECTIVES In this study, we examined the prevalence and correlates of current synthetic cannabinoid (SC) use among high school seniors in the United States. METHODS Monitoring the Future, an annual nationally representative survey of high school seniors, began querying current (30-day) SC use in 2014. Data were examined from the 2 most recent cohorts (2014–2015; N = 7805). Prevalence of self-reported use was examined and differences in demographics and recency and frequency of other drug use was compared between current marijuana-only users and current SC (plus marijuana) users using χ2 and generalized linear model using Poisson. RESULTS We found that 2.9% of students reported current SC use; 1.4% of students (49.7% of users) reported using SCs on ≥3 days in the past month. SC users were more likely to report more recent (and often more frequent) use of lysergic acid diethylamide, cocaine, heroin, and/or nonmedical use of opioids compared with marijuana-only users. Compared with current marijuana-only users, SC users were more likely to report lower parent education (P < .05) and current use of a higher number of illegal drugs other than marijuana (Ps < .001). Students using SCs ≥10 times in the past month were more likely to be boys, frequent marijuana users (Ps < .01), African American, and users of multiple other illegal drugs (Ps < .001). CONCLUSIONS SC use is typically part of a repertoire of polydrug use, and polydrug use is less prevalent among marijuana-only users. Current SC users are at risk for poisoning from use of the newest generation of SCs and from concurrent drug use.
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"Partie I : Chaleur, mouvement, énergie." In Vers la voiture sans pétrole ?, 13–14. EDP Sciences, 2020. http://dx.doi.org/10.1051/978-2-7598-0219-7-002.
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"Remerciements." In Les joints de grains, vii—viii. EDP Sciences, 2020. http://dx.doi.org/10.1051/978-2-7598-0241-8-002.
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"Préface." In Pionniers de la radiothérapie, vii—x. EDP Sciences, 2020. http://dx.doi.org/10.1051/978-2-7598-0210-4-002.
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"Résumé." In Contamination des sols, 3–4. EDP Sciences, 2020. http://dx.doi.org/10.1051/978-2-7598-0261-6-002.
Full textConference papers on the topic "004.021, 004.052.2"
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Ward, M., T. Pavlina, R. Butchin, R. Johnson, and R. Cotter. "RAPID ONSET INHIBITION OF AFRICAN GREEN MONKEY PLATELETS AFTER INTRAVENOUS ADMINISTRATION OF A MARINE OIL LIPID EMULSION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643386.
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To evaluate how rapidly and to what extent a lipid emulsion rich in n-3 fatty acids could alter platelet function, six male juvenile African Green Monkeys (4-6 kg) were given a 6-hour IV continuous infusion of a 10% marine oil (MO) lipid emulsion (5 ml /kg/hr). Following a 21-day washout period, the same monkeys were given a similar infusion of a 10% soybean oil (SO) lipid emulsion (TRAVAMULSION®, Travenol Labs). Blood samples were collected pre-infusion, and at 6, 12, and 24 hours following initiation of infusion, upon which the following were measured: whole blood platelet aggregation and thromboxane B2 release following collagen activation, platelet count, and platelet total fatty acid composition (pre-infusion and 24 hrs only). Lipid Emulsion Fatty Acid Composition: mg/ml(% total F.A.) Both emulsions elicited comparable reductions in both platelet aggregation and thromboxane B2 release immediately following infusion (6 hr). Platelet aggregation response after MO was significantly less than that after SO at both 12 (pc.001) and 24 hrs (p<.001), and thromboxane B2 release was significantly less after MO vs SO at 24 hrs (p<.03). Platelet counts remained unchanged after both treatments. Platelet total fatty acid analyses revealed significant increases in % total F.A. for C20:5 [1.87(pre) vs 4.79(24hr); p<.005] and for C22:6 [1.09(pre) vs 3.15(24hr); p<.001] and significant decreases in % total F.A. for C18:2 [8.94(pre) vs 7.77(24hr); p<.05] and C20:4 [22.6(pre) vs 19.6(24hr) p<.05], following infusion of M0. Following infusion of SO, the % total F.A. change in C22:6 was the only one of significance [0.85(pre) vs 1.25(24hr); p<.05]. This was attributed to the C18:3 in the SO lipid emulsion. Whereas the IV infusion of an n-6 rich lipid emulsion has little effect upon platelet fatty acid composition and function, similar administration of an n-3 rich lipid emulsion markedly reduces platelet function and effects a significant increase in the n-3/n-6 fatty acid ratio of the platelets.
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Humm, Hans J., Christoph R. Gossweiler, and George Gyarmathy. "On Fast-Response Probes: Part 2 — Aerodynamic Probe Design Studies." In ASME 1994 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1994. http://dx.doi.org/10.1115/94-gt-027.
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The influence of the probe size and geometry on the quality of fast-response measurements in turbomachines has been experimentally investigated. For investigations in the static domain (time independent flows) probes were calibrated in two continuously operating wind tunnels in the range 0.2< Ma < 1.2. For dynamic calibrations in time variant flows model experiments in water (0.025 < k < 0.4, reduced frequency) were performed. Aerodynamic characteristics were determined for a great number of probe geometries such as circular cylinders and wedge-type probes with varied apex angles, locations of the sensing holes and leading edge shapes. The experiments comprised investigations in tolerance ranges for prismatic total pressure probes, yaw angle sensitivity, yaw angle and Mach number effects on calibration and influence of dynamic yaw angle fluctuation on probe characteristics. As a result of the experiments errors due to static and dynamic aerodynamic effects could be quantified. The majority of the errors arising during measurements in turbomachines can be directly related to the probe size. An important number of these errors are systematic and can be analytically modelled and hence their influence corrected. In fluctuating flows the most severe measurement errors, which often may exceed the quantity of interest, are due to dynamic stall effects. This phenomenon, which is of transient nature and cannot be corrected, is typical for sharp wedge probes but is not present with circular cylinders or the effects being much smaller with very blunt wedges.
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Iacovides, H., and B. E. Launder. "Parametric and Numerical Study of Fully-Developed Flow and Heat Transfer in Rotating Rectangular Ducts." In ASME 1990 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1990. http://dx.doi.org/10.1115/90-gt-024.
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This work is concerned with fully-developed constant-density turbulent flow through rectangular straight ducts rotating in an orthogonal mode. Ducts of both square and 2:1 aspect ratio cross-sections have been examined. For the square duct, predictions have been performed for Reynolds numbers of 33,500 and 97,000 and for the 2:1 aspect ratio duct the computations were carried out for a Reynolds number of 33,500. Values of the inverse Rossby number (Ro = ΩD/Wb) ranged from 0.005 to 0.2. Except in the immediate vicinity of the wall, the standard high-Reynolds-number version of the k-ε model is used to account for the effects of turbulence. Across the near-wall sublayer the damping of turbulence is modelled through a low-Reynolds-number one-equation model. Low rotational speeds cause the formation of a pair of symmetric streamwise vortices. At higher rotational speeds, flow instabilities on the pressure side lead to transition to a more complex four-vortex structure. The transition point depends on both the cross-sectional geometry and the flow Reynolds number. Moreover, over a range of Rossby number, either two- or four-vortex solutions are possible depending upon initial conditions. The rotation leads to significant differences between the values of friction factor and Nusselt number on the suction and pressure surfaces of the duct. The degree of heat transfer augmentation on the pressure side is found to depend on the Reynolds number as well as on Rossby number. In contrast, heat-transfer attenuation on the suction side is only Rossby-number dependent.
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Ji, Yulong, Jiantong Xu, Weichen Gao, Huilong Yan, Fengmin Su, and Hongbin Ma. "Experimental and Theoretical Study on the Effect of Pressure and Surface Roughness on Thermal Contact Resistance With LMA As TIM." In ASME 2019 6th International Conference on Micro/Nanoscale Heat and Mass Transfer. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/mnhmt2019-4083.
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Abstract The recent research show that low melting temperature alloys (LMA) is a prospective thermal interface material (TIM). However, the effect of surface roughness and interface contact pressure on the thermal contact resistance with LMA as TIM is unclear. In the current research, copper plates with surface roughness of 0.28 μm, 0.54 μm, 0.96 μm and 2.59 μm were fabricated to make different test samples. Low melting temperature alloys Ga62.5In21.5Sn16 was used as TIM to make the Cu-LMA-Cu three-layer structure samples. The thermal contact resistance of these samples under different pressure of 0.05 MPa, 0.1 MPa, 0.15 MPa, 0.2 MPa, 0.4 MPa and 0.6 MPa were measured based on the steady state method. The results show that when the pressure of 0.05 MPa, 0.1 MPa, 0.15 MPa, 0.2 MPa, 0.4 MPa, 0.6MPa is applied to the samples, the thermal contact resistance of sample with surface roughness of 0.28 μm decreased by 74.3%, 71.1%, 70.1%, 71.5%, 70.8%, 70.1% compared with that of the sample with surface roughness of 2.59 μm. In order to further study the influence of the factors on the thermal contact resistance, a theoretical model of solid-liquid-solid thermal contact resistance with contact pressure and surface roughness as factors was developed. Based on theoretical model, it is concluded that (1) the thermal contact resistance decreases as the pressure increases, and gradually stabilizes; (2) as the surface roughness increases, the thermal contact resistance increases; (3) As the surface roughness decreases, the influence of contact pressure on thermal contact resistance decreases. The above conclusions were verified by test results.
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Nakka, Thejeswar, Prasanth Ganesan, Luxitaa Goenka, Biswajit Dubashi, Smita Kayal, Latha Chaturvedula, Dasari Papa, Prasanth Penumadu, Narendran Krishnamoorthy, and Divya B. Thumaty. "Epithelial Ovarian Cancer: Real-World Outcomes." In Annual Conference of Indian Society of Medical and Paediatric Oncology (ISMPO). Thieme Medical and Scientific Publishers Pvt. Ltd., 2021. http://dx.doi.org/10.1055/s-0041-1735369.
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Abstract Introduction Ovarian cancer is the third most common cancer and the second most common cause of death among gynecological cancers in Indian women. Ovarian cancer is heterogeneous, among them, epithelial ovarian cancer (EOC) is the most common. Primary cytoreductive surgery along with six to eight cycles of a combination of platinum and taxanes chemotherapy is the cornerstone of first-line treatment in EOC. This study was done to find clinicopathological factors affecting survival outcomes with first-line therapy in EOC in a real-world setting. Objectives This study was aimed to find factors affecting progression-free survival (PFS) and overall survival (OS) with first-line treatment in EOC. Materials and Methods We conducted a single-center retrospective study. We screened all the patients diagnosed with ovarian cancer from January 2015 till December 2019. We locked data in August 2019. Eligible patients were histologically confirmed EOC who underwent primary cytoreduction or received more than or equal to two cycles of chemotherapy or both. Patients who had received first-line treatment at another hospital were excluded. Results Patients demographics and clinical characteristics: between January 5, 2015 to August 31, 2019, 435 patients with a diagnosis of ovarian malignancy were registered at our center. Among them, 406 (82%) had EOC, 290 (64%) newly diagnosed, and fulfilling eligibility criteria were included in the final analysis. The median age of the cohort was 53 years (range: 21–89 years) and 157 patients (54%) were >50 years of age (the Eastern Oncology Cooperative Group Performance status was ≥ 2 in 124 patients [43%]; median duration of symptoms was 3 months; and stage III/IV: 240 [83%]). Grading of the tumor was available in 240 patients of which 219 (91%) were of high grade. Subtyping was available in 272 patients (94%) of which the serous subtype was the most common constituting 228 patients (79%).Treatment Most patients received chemotherapy (n = 283 [98%]) as the first modality of treatment (neoadjuvant/adjuvant and palliative). As neoadjuvant (NACT) in 130 patients (45%) and as adjuvant following surgery in 81 patients (29%). The most common chemotherapy regimen was a combination of carboplatin and paclitaxel in 256 patients (88%). Among 290 patients 218 (75%) underwent cytoreductive surgery. Among them, optimal cytoreduction was achieved in 108 patients (52%). Optimal cytoreduction rate (OCR) with upfront surgery and after NACT was 44 and 53%, respectively (Chi-square test: 0.86; p = 0.35).Survival The median follow-up of the study was 17 months (range: 10–28 months) and it was 20 months (range: 12–35 months) for patients who were alive. At last, follow-up, 149 patients (51%) had progressed and 109 (38%) died. The estimated median PFS and OS were 19 months (95% CI: 16.1–21.0) and 39 months (95% CI: 29.0–48.8), respectively. On multivariate analysis, primary surgery (HR: 0.1, 95% CI: 0.06–0.21; p-value: <0.001) and early-stage disease (HR: 0.2, 95% CI: 0.1–0.6; p-value 0.04) were associated with superior PFS and primary surgery (HR: 0.1, 95% CI: 0.09–0.2; p-value: <0.001) was associated with superior OS. Conclusion Primary surgery (upfront or interval) was associated with improved survival. Newer agents like bevacizumab, poly-ADP (adenosine diphosphate)-ribose polymerase inhibitors and HIPEC should be incorporated precisely into first line of therapy to improve outcomes.
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Coller, B. S., J. D. Folts, S. R. Smith, and L. E. Scudder. "ABOLITION OF IN VIVO PLATELET THROMBUS FORMATION WITH MONOCLONAL ANTIBODIES TO THE PLATELET GPIIb/IIla RECEPTOR: CORRELATION WITH PLATELET AGGREGATION AND BLEEDING TIME." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643703.
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We previously reported that 0.8 mg/kgof the F(ab’)2 fragment of antibody 7E3, directed at theplatelet GPIIb/IIIa receptor, can abolish periodic platelet thrombus formation on partially stenosed carotid arteries in monkeys (Mnks). The present study was designed to: 1) test another antibody to GPIIb/IIIa (10E5), 2)find the minimum effective dose, and 3) correlate this effect with changesin the template bleeding time (BT) and platelet aggregation (PA). Periodicplatelet thrombi were established in the carotid arteries of 7 anesthetized Mnks after mechanical stenosis (∽70%) and intimal damage. 4 Mnks were treated with 7E3. Mnks 1 and 2 were given 0.2 mg/kg, and this dose: abolished thrombus formation and prevented its return in response to epinephrine infusion and increased intimal damage; abolished PA in response to ADP (10 μM); and increased the BT from 8.5 to 16 min and from 5 to 11 min. Mnk 3 was given 0.1 mg/kg, and this dose abolished the thrombi, inhibited PA by ∽41% and increased the BT only to 10 minfrom 8 min. Mnk 4 was givenincremental doses of 7E3. After 0.1 mg/kg, thrombi were reduced but not abolished, PA was minimally inhibited and the BTwas unchanged (7.5 vs 8 min pre). Afteranother 0.1 mg/kg, thrombi were abolished but could be partially restoredwith extreme provocation, PA was abolished and BT remained 7.5min. Afteranother 0.2 mg/kg, thrombicould not berestored, PA was abolished and the BTincreased to 21 min. After a final0.2mg/kg, the BT increased to 33 min. 3 Mnks were treated with 10E5. Mnk1received 0.4 mg/kg: thrombi and PA werebothabolished, and the BT increased from 5.5 to 14.5 min.Mnk 2 received 0.2mg/kg: thrombi and PA were again abolished while the BT increased to8.5from4.5 min. Mnk 3 received 0.1 mg/kg, and this abolished thrombus formation,butinhibitedPA by only ∽50%and increasedthe BT minimally (7.5 to 8.5 min). Increasedoozing from the neckwounds wasonly observed in animals with significant BT prolongations.We conclude that ∽0.1-0.2 mg/kg of eitherantibody can abolish in vivo thrombusformation, and that it is not necessary to abolish PA or cause marked prolongation ofthe BT in order toabolishthrombus formation in this model.
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Blair, S. D., K. K. Tan, C. N. McCollum, and R. M. Greenhalgh. "THE EFFECT OF COAGULATIOU CHANGES ON THE OUTCOME OF GASTROINTESTINAL HAEMORRHAGE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644799.
Full textAbstract:
Blood is hypercoagulable following GI haemorrhage [1], and vascular thrombosis has been reported to be the main cause of death [2]. To study the relationship between coagulation and clinical outcome, Impedance Clotting Time (ICT) wac measured daily using the Biobridge [1] and clinical outcome prospectively recorded in 125 patients with acute severe GI haemorrhage.Mean (±se mean) ICT on admission was markedly shortened at 4.8±0.2 mins (normal range 8-12 mins) (p<0.001, t-Cest). Sixty patients received blood transfusion within 24 hours resulting in significantly prolonged ICT of 6.2±0.4 mins compared to 4.0±0.3 mins in the 56 not transfused (p<0.01). In 23 patients who rebled, the ICT at 24 hours of 6.7±0.4 mins demonstrated reduced hypercoagulability. Twenty of these 23 patients had bee:: transfused prior to rebleeding, a significantly greater proportion than in those who did not rebleed (p<0.00l). Six patients died, 3 of myocardial infarction, 1 of stroke, and 2 of continued haemorrhage. Mean ICT in the 4 patients dying from thrombotic vascular disease was 2.3±0.1 mins although 2 had also rebled.Clinical outcome in GI haemorrhage is strongly related to coagulation changes. The main cause of death was thrombotic vascular disease.1. Blair SD, Janvrin SB, McCollum CN, Greenhalgh RM. The effect of early blood transfusion on gastrointectinal haemorrhage. Br J Surg 1986; 73: 792-4.2. Allan R, Dykes P. A study of the factors influencing mortality rates fron gastrointestinal haenorrhage. Quart JMed 1976; 180: 533-50.
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Heang, Sorphea, Ramunė Albrektienė, and Dainius Paliulis. "Investigation of Lead and Iron Removal from Groundwater Using Sapropel and Quartz Sand." In 11th International Conference “Environmental Engineering”. VGTU Technika, 2020. http://dx.doi.org/10.3846/enviro.2020.737.
Full textAbstract:
In Prey Nop district of Cambodia, a district in coastal area, it was observed that concentration of iron and lead in groundwater was higher than permissible values. Lead is a highly toxic heavy metal, while iron is an element causing several problems related to the deterioration of taste and aesthetic appearance of water and the capacity reduction of water supply pipelines. Therefore, this article investigates the effectiveness of the technology for removing lead and iron from groundwater using the cheapest materials like sapropel and sand. In this study, different doses of sapropel (0.1, 0.2, 0.4, 0.5, 0.6, 0.8, 1, 2, 3, 4, 5 and 6 g/L), different durations of sorption processes (30, 60, 90, 120 and 150 min) and a laboratory bench for iron filtration filled with quartz sand were used for lead and iron ions removal. Results from the bench tests showed that both iron and lead were removed at efficiencies of 70 and 97%, and their concentrations did not exceed the permissible levels by using the lowest dose of 0.1 g/L of sapropel for sorption of lead and filtration through quartz sand filters for iron removal.
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Bunker, R. S., D. E. Metzger, and S. Wittig. "Local Heat Transfer in Turbine Disk-Cavities: Part II — Rotor Cooling With Radial Location Injection of Coolant." In ASME 1990 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1990. http://dx.doi.org/10.1115/90-gt-026.
Full textAbstract:
Detailed radial distributions of rotor heat transfer coefficients are presented for three basic disk-cavity geometries applicable to gas turbines. The experimental apparatus has been designed to obtain local heat transfer data on a number of easily interchangeable rotor surfaces. The method employs thin thermochromic liquid crystal coatings upon the rotor surfaces together with video system data acquisition and computer-assisted image analysis to detect surface color display and to extract heat transfer information. A thermally transient, aerodynamically steady technique is used which attains consistent thermal boundary conditions over the entire disk-cavity. Cooling air is introduced into the disk-cavity via a single circular jet mounted perpendicularly into the stator at one of three radial locations; 0.4, 0.6 or 0.8 times the rotor radius. Rotor heat transfer coefficients have been obtained over a range of parameters including disk rotational Reynolds numbers of 2 to 5 · 105, rotor/stator hub spacing-to-disk radius ratios of .025 to .15, and jet mass flow rates between .10 and .40 times the turbulent pumped flow rate of a free disk. The rotor surfaces include a parallel rotor-stator system, a rotor with 5 percent diverging taper, and a similarly tapered rotor with a rim sealing lip at its extreme radius. Results are presented showing the effects of the parallel rotor, which indicate strong variations in local Nusselt numbers for all but rotational speed. These results are compared to associated hub injection data of Part I of this study, demonstrating that overall rotor heat transfer is optimized by either hub injection or radial location injection of coolant dependent upon the configuration. Results with the use of the tapered rotor show significant local Nusselt number radial variation changes over those of the parallel rotor, while the addition of a rim sealing lip appears to increase the level of the radial distribution.
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Finnicum, David J. "Regulatory Guide 1.200 PRA Peer Reviews: A Peer Reviewer Perspective." In 16th International Conference on Nuclear Engineering. ASMEDC, 2008. http://dx.doi.org/10.1115/icone16-48152.
Full textAbstract:
In January 2007, the NRC issued Revision 1 to Regulatory Guide (RG) 1.200 endorsing Addendum B of the ASME PRA Standard, RA-Sb-2005. Effective January 1, 2008, the probabilistic risk assessment (PRA) supporting any risk-informed application must comply with the requirements of RG 1.200 and the ASME PRA Standard, as explained in NRC’s Regulatory Issue Summary (RIS) 2007-06. Per Section 6 of the ASME PRA Standard, a peer review must be performed to demonstrate compliance with the ASME PRA Standard. In the late 1990s, all nuclear plants in the U. S. had a peer review performed in accordance with NEI 00-02. However, the ASME PRA Standard requirements are more extensive than the review elements in NEI 00-02. Appendix D of NEI 00-02, endorsed by Appendix B of RG 1.200, includes a self-assessment process for using the NEI 00-02 results to, in part; assess a PRA’s compliance with the ASME PRA Standard. The ASME PRA Standard requires a peer review for any PRA element that has been upgraded since the original peer review. There is also the consideration that if the PRA updates have resulted in enough changes to the model that the current model no longer is adequately represented by the model that was originally peer reviewed, then, at their discretion, the utility may request a new peer review. Both the Boiling Water Reactor Owners Group (BWROG) and the Pressurized Water Reactor Owners Group (PWROG) have authorized projects to conduct the peer reviews against RG 1.200, Revision 1 to support risk-informed applications after January, 2008. Two key elements have changed since the original NEI 00-02 peer reviews. These are: (1) the number of specific requirements that need to be reviewed and (2) the need for the utility undergoing a peer review to complete a self-assessment and a roadmap to the documentation supporting their assessment to enable the peer review team to complete their review within a reasonable timeframe. Since the original approval of the ASME PRA Standard in 2003, many plants have performed self-assessments either internally or with the assistance of contractors to ascertain their compliance with the ASME PRA Standard. A number of lessons have been learned as a result of these self-assessments that should be carried forward to the next round of formal peer reviews against Addendum B of the ASME PRA, RA-Sb-2005. This paper examines some of the lessons learned while performing these self-assessments, and provides some guidance for a pre-review self-assessment and as well as some guidelines on compiling a roadmap to support the self-assessment and the peer review.