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Dissertations / Theses on the topic 'ΑVβ6 integrin'

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Published: 22 February 2025

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1

Marsh, D. J. "The αvβ6 integrin in cancer". Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1331896/.

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The epithelial restricted αvβ6 integrin is known to have minimal expression in healthy tissue and to be upregulated in cancer and healing wounds. This thesis explores the role of αvβ6 in cancer and tests the hypothesis that αvβ6 has a prognostic and therapeutic utility in cancer. Using immunohistochemistry, increased αvβ6 expression was found in nonmelanoma skin cancers (NMSC), particularly in morphoeic type basal cell carcinoma. In cell culture experiments, αvβ6 was found to activate TGF-β and promote myofibroblast differentiation, producing a tumour stroma rich in smooth muscle actin (SMA).
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2

Vallath, Sabarinath S. "Studying the role of integrin αVβ6 in pancreatic cancer". Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8663.

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Pancreatic cancer is often referred to as the “silent killer“ due to the asymptomatic nature of the disease in the early stages and the extremely poor prognosis overall. The average one-year survival rate for PDAC patients is 24% (American Cancer Society, facts and figures, 2010), decreasing to 5%-6% over 5 years (WHO report, Pancreatic cancer, 2010). Only 20% of patients are suitable for surgical resection at the time of diagnosis and treatment options available to PDAC patients have not improved significantly over the past few decades. Thus novel therapeutic approaches are essential to treat
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3

Hayward, Mary-Kate. "Mechanostimulation of integrin αvβ6 and fibronectin in DCIS myoepithelial cells". Thesis, Queen Mary, University of London, 2018. http://qmro.qmul.ac.uk/xmlui/handle/123456789/54057.

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Alterations to the tumour microenvironment is a common feature of many cancers, including breast cancer, and there is increasing evidence that alterations to the microenvironment, including; increased integrin expression, ECM deposition and protease activity, promote cancer progression. Most invasive breast cancers arise from a preinvasive stage, ductal carcinoma in situ (DCIS). Previous work in our laboratory has shown the microenvironment of DCIS is altered, such that myoepithelial cells (MECs) switch to a tumour-promoting phenotype, associated with upregulation of integrin αvβ6 and fibronec
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4

Ylipalosaari, M. (Merja). "Matrix metalloproteinases (MMPs) in oral carcinomas." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514277309.

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Abstract Matrix metalloproteinases, MMPs, are a family of enzymes capable of modulating connective tissue components. The expression of several MMPs is increased in oral squamous cell carcinomas (OSCCs). They are assumed to have an important role in the development and progression of OSCCs. However, the exact role and mechanism of the regulation of MMPs in malignant transformation are still largely unknown. In this study, tumour-associated trypsin-2 (TAT-2) was detected in OSCC tissue sections, and its role in MMP-2 and -9 regulation in carcinoma cells was evaluated. The TAT-2 gene was trans
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5

Dirheimer, Luca. "Ciblage de modèles cellulaires 3D par des agents de contrastes fluoresçant dans le proche infrarouge : application à la chirurgie guidée par la fluorescence des cancers de la tête et du cou." Electronic Thesis or Diss., Université de Lorraine, 2024. http://www.theses.fr/2024LORR0159.

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La résection chirurgicale constitue le traitement de première intention des cancers de la tête et du cou (HNSCC). La berge peropératoire est un facteur de pronostic majeur pour la survie globale des patients. Actuellement, il existe peu d’outils pour discriminer de manière fiable et en temps réel le tissu tumoral du tissu sain. La chirurgie guidée par la fluorescence (FGS) proche infrarouge (NIR) est une méthode d’imagerie utilisant le marquage fluorescent des tissus tumoraux afin de fournir une image de contraste augmentée. Le but de ces travaux est l’étude de la distribution de Quantum Dots
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Nieberler, Markus [Verfasser], Klaus-Dietrich Akademischer Betreuer] Wolff, Andreas [Akademischer Betreuer] Kolk та Henning [Akademischer Betreuer] [Bier. "Entwicklung und klinische Etablierung einer intraoperativen zytologischen Diagnostik der Knocheninfiltration bei Kopf-Hals-Karzinomen mit Charakterisierung von αvβ6 Integrin als Biomarker invasiver Karzinomzellen / Markus Peter Nieberler. Gutachter: Klaus-Dietrich Wolff ; Andreas Kolk ; Henning August Bier. Betreuer: Klaus-Dietrich Wolff". München : Universitätsbibliothek der TU München, 2014. http://d-nb.info/1058214454/34.

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7

Mathias, Lucas Solla. "Ativação da via MAPK/ERK e Integrina αvβ3 pela ação da triiodotironina (T3) na modulação da expressão gênica de adipocinas e modificação do perfil lipídico em adipócitos, 3T3-L1". Botucatu, 2019. http://hdl.handle.net/11449/181721.

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Orientador: Miriane de Oliveira<br>Resumo: Introdução: O hormônio triiodotironina (T3) influencia o metabolismo e desenvolvimento do tecido adiposo (TA), modulando a proliferação e diferenciação de adipócitos, podendo agir sobre os reguladores do processo de adipogênese, como o receptor ativado por proliferador de peroxissomo (PPARy). O TA está envolvido na regulação da energia corporal, sintetizando e secretando substâncias denominadas adipocinas, dentre elas a adiponectina e leptina. A adiponectina está relacionada ao aumento da sensibilidade à insulina, enquanto a leptina está envol
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8

Elsharif, Amal A. M. "Functional Investigation of Dual αvβ3 and αllbβ3 Integrin Inhibition in Haematological and Solid Tumour Models". Thesis, University of Bradford, 2018. http://hdl.handle.net/10454/16883.

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Invasion and metastasis of cancer is the leading cause of increased mortality. In addition, haematological malignancies (leukaemia and lymphoma) are a significant cause of morbidity and mortality in both children and adults. Therefore, new treatments which will inhibit cancer progression are required. Integrin adhesion receptors, particularly the RGD-binding integrin subfamily comprising αvβ3, αvβ5, αvβ6, αvβ8, αllbβ3, α5β1, α8β1 and αvβ1 are related to progress and spread of cancer and poor prognosis. Because of the importance of integrin biology in the regulation of cancer dissemination, the
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9

Ahmedah, Hanadi Talal A. "Correlation between the expression of integrins and their role in cancer progression : expression pattern of integrins αvβ3, αvβ5 and α5β1 in clinical and experimental tumour samples". Thesis, University of Bradford, 2015. http://hdl.handle.net/10454/14284.

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The integrins play a crucial role in cancer cell proliferation, migration, differentiation, survival and angiogenesis. It has been shown that integrin expression is positively correlated to cancer dissemination, this suggests targeting selected integrins as an anti-metastatic strategy. The aim of this study is to investigate the effect of novel antagonists of α5β1, αvβ3 and αvβ5 integrins on cancer cell migration, a key process in tumour cell dissemination. Immunohistochemistry was used to evaluate the expression of α5, αv, β3 and β5 integrin subunits in prostate cancer tissues. Furthermore th
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Ahmedah, Hanadi T. A. "Correlation between the expression of integrins and their role in cancer progression. Expression pattern of integrins αvβ3, αvβ5 and α5β1 in clinical and experimental tumour samples". Thesis, University of Bradford, 2015. http://hdl.handle.net/10454/14284.

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The integrins play a crucial role in cancer cell proliferation, migration, differentiation, survival and angiogenesis. It has been shown that integrin expression is positively correlated to cancer dissemination, this suggests targeting selected integrins as an anti-metastatic strategy. The aim of this study is to investigate the effect of novel antagonists of α5β1, αvβ3 and αvβ5 integrins on cancer cell migration, a key process in tumour cell dissemination. Immunohistochemistry was used to evaluate the expression of α5, αv, β3 and β5 integrin subunits in prostate cancer tissues. Further
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Alshammari, Fatemah O. F. O. "An immunohistopathological and functional investigation of β3 integrin antagonism as a therapeutic strategy in cancer : characterisation, development, and utilisation of preclinical cancer models to investigate novel β3 integrin anatgonists". Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/6327.

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Tumour cell dissemination is a major issue with the treatment of cancer, thus new therapeutic strategies which can control this process are needed. Antagonism of integrins highly expressed in tumours is one potential strategy. The integrins are transmembrane glycoprotein adhesive receptors. Two of the integrins, αVβ3 and αIIbβ3, are highly expressed in a number of tumours and induce bi-directional signalling through their interaction with extracellular matrix proteins, and growth factor receptors. Through this signalling they play an important role in a number of cellular processes that are in
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Antonow, Michelli Barcelos. "Desenvolvimento e caracterização físico-química de nanocápsulas multiparedes complexadas com zinco e funcionalizadas com RGD para reconhecimento por integrinas ανβ3 presentes em células tumorais". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/149502.

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A funcionalização de superfície nas nanocápsulas contendo doxorrubicina com o peptídeo RGD é uma estratégia promissora devido a ligação preferencial na integrina αvβ3 expressa em células tumorais. Este estudo objetivou o desenvolvimento, caracterização e estudos biológicos de nanocápsulas multiparedes com doxorrubicina e funcionalizadas com RGD. Para isso, na primeira etapa do trabalho foi realizada a síntese do peptídeo RGD. Os produtos obtidos foram caracterizados por análises de infravermelho e RMN de 1H. Na segunda etapa foram desenvolvidas formulações de nanocápsulas com doxorrubicina ou
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13

Acharya, Mridu. "Expression and function of the αVβ5 integrin during human B lymphopoiesis". Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/172/.

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The integrin αVβ5 is a receptor for sCD23 molecule and the αVβ5-CD23 interaction sustains proliferation of the pre-B cell line SMS-SB. This thesis describes further investigation into the role of αVβ5 integrin during human B cell development. B cell development in the bone marrow involves stepwise maturation of progenitor cells through different defined stages. A tight regulation of proliferation and differentiation mediates the progression of progenitor cells through this developmental pathway. A variety of signals from soluble molecules and adhesive interactions regulate this balance of prol
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14

Seelke, Sandra [Verfasser], Nina [Akademischer Betreuer] Kollmar, Sigrid [Akademischer Betreuer] Hoyer-Fender та Wilfried [Akademischer Betreuer] Kramer. "Untersuchung bispezifischer Intradiabodies gegen die Integrine αvβ3, αvβ5 und α5β1 auf ihre anti-angiogenen Eigenschaften / Sandra Seelke. Gutachter: Sigrid Hoyer-Fender ; Wilfried Kramer. Betreuer: Nina Kollmar". Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://d-nb.info/1044173068/34.

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15

Alkhedaiade, Adel Qlayel Hamdan. "Studies of αvβ integrin functions in human B cell precursors". Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/3044/.

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The αVβ5 integrin is a member of integrin family that binds to different ligands such as vitronectin, fibronectin and soluble CD23 in order to mediate different biological responses such as cell growth, adhesion and metastasis. It is expressed by B cell precursors and by different acute lymphocytic leukaemia cell lines such as SMS-SB cells. This thesis is an attempt to explain how the sCD23- αVβ5 integrin interaction stimulates SMS-SB cell growth and to study the role of the αVβ5 integrin and other receptors such as PDGF receptor and CXCR4 in B cell development in the bone marrow. The maturati
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Fenton, Thomas. "Integrin αvβ8 on human dendritic cells : a role in intestinal immune homeostasis". Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/integrin-alphav8-on-human-dendritic-cells-a-role-in-intestinal-immune-homeostasis(3820bc76-2c42-4db6-a344-b66e5b77769d).html.

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Intestinal inflammatory disorders such as Crohn’s disease contribute significantly to human mortality and morbidity. Although the cells and molecules involved in suppression of intestinal inflammation have been extensively documented in mouse models, a full understanding of how these work together in the healthy and diseased gut remains elusive. It is known, however, that tight regulation over TH17 cells and regulatory T cells (Treg) is required to maintain immune homeostasis in the intestine. Activation of the cytokine transforming growth factor-β (TGFβ), which is secreted by immune cells as
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Steri, Veronica. "Elucidating the role of endothelial αvβ3-integrin in tumour growth and angiogenesis". Thesis, University of East Anglia, 2015. https://ueaeprints.uea.ac.uk/56762/.

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Angiogenesis, the formation of new vessels from pre-existing ones, is essential for primary tumour growth as well as for metastasis, and endothelial cells play a central role in this process: they drive blood vessel formation in response to signals from the local environment by a mechanism that is integrin-dependent. αvβ3-integrin seemingly poses an ideal anti-angiogenic target. Its expression is vastly up-regulated in neo-angiogenic vessels, while its expression in quiescent vasculature is minimal. However, anti-angiogenic therapy targeting αvβ3-integrin has proven somewhat disappointing. In
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18

Schäfer, Markus [Verfasser], та M. [Akademischer Betreuer] Bastmeyer. "Mechanische Kräfte regulieren die Bindungspromiskuität von αVβ3-Integrin / Markus Schäfer ; Betreuer: M. Bastmeyer". Karlsruhe : KIT-Bibliothek, 2019. http://d-nb.info/1200471148/34.

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Andriu, Alexandra. "Evaluating the utility of αvβ3 integrin antagonists to detect and treat angiogenic tumour cells". Thesis, University of Aberdeen, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=240026.

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Tumour angiogenesis, the formation of new blood vessels within a tumour, is a hallmark of cancers, that allows them to grow beyond a critical size and to metastasize to other organs. As the key driver of tumour angiogenesis, αvβ3 integrin is both an established therapeutic target for anti-angiogenic drugs and a biomarker for imaging agents. Accurate detection of αvβ3 integrin in angiogenic tumours impacts patient prognosis and could report on therapy response. Over the last twenty years, novel αvβ3 integrin-targeted radiotracers have been developed for PET imaging of tumour angiogenesis. While
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van, Wieringen Tijs. "Intra- and Extracellular Modulation of Integrin-directed Connective Tissue Cell Contraction." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-102349.

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All blood vessels in the microvasculature are embedded in loose connective tissue, which regulates the transport of fluid to and from tissues. The intersti-tial fluid pressure (IFP) is one of the forces that control this transport. A lowering of IFP in vivo results in an increased transport of fluid from the circulation into the underhydrated connective tissues, resulting in edema formation. During homeostasis, contractile connective tissue cells exert a tension on the connective tissue fibrous network by binding with β1 in-tegrins, thereby actively controlling IFP. During inflammation, the IF
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Casals, Soler Gemma. "Investigación de la osteopontina y la integrina αvβ3 como marcadores de receptividad endometrial para la implantación embrionaria". Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/301774.

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El estudio del endometrio y de su estado de receptividad para la implantación embrionaria es crucial en la evaluación de la fertilidad de la mujer. No obstante, se ha demostrado que el estudio histológico clásico carece de utilidad clínica práctica para valorar la adecuada capacidad del endometrio para implantar embriones. Por tanto, la búsqueda de nuevos marcadores de receptividad endometrial constituye una línea de investigación de gran interés. Se ha descrito que tanto la integrina αvβ3 como la osteopontina presentan unos patrones de expresión temporales y espaciales específicos en los dife
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Shuttleworth, Elinor. "The role of integrin αvβ8 on human monocytes and macrophages in intestinal immune homeostasis". Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-integrin-alpha-v-beta-8-on-human-monocytes-and-macrophages-in-intestinal-immune-homeostasis(b1f62522-19ba-49d7-8b09-b9d8e1bbbf6b).html.

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Intestinal immune cells remain tolerant to the trillions of commensal bacteria present in the gut, with perturbations of this process implicated in development of inflammatory bowel disease (IBD). The cytokine TGF-β is a key factor promoting intestinal immune tolerance, but is secreted in a latent state that requires activation to function. Binding of TGF-β to the integrin αvβ8 is a principal mechanism of TGF-β activation, with mouse models demonstrating a crucial role for αvβ8 expression by dendritic cells and regulatory T cells in intestinal immune regulation. Despite this evidence, very lit
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Burgett, Monica E. "Direct contact with perivascular tumor cells enhances integrin αvβ3 signaling and migration of endothelial cells". Kent State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=kent1466174564.

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FIRMO, MORAIS EDUARDO MANUEL. "Role of αVβ3 integrin in cortical synaptic transmission: relevance for Autism Spectrum Disorder and Epilepsy". Doctoral thesis, Università degli studi di Genova, 2019. http://hdl.handle.net/11567/942181.

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Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders characterized by social communication impairments and restricted interests. Epilepsy is a brain disorder diagnosed after the occurrence of at least one epileptic seizure. ASD and epilepsy are often comorbid. The integrin αVβ3 is a synaptic cell adhesion molecule that binds to counter-receptors and extracellular matrix proteins. Itgb3, the gene encoding the β3 subunit of integrin αVβ3, has been associated to ASD in humans, and constitutive knockout (KO) mice for this gene exhibit ASD-like behaviors, while brain-specific
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Raj, April. "Mechanistic studies to evaluate the targeting specificity of novel RGD Micelles to the αVβ3 integrin receptor". Scholarly Commons, 2012. https://scholarlycommons.pacific.edu/uop_etds/830.

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Current chemotherapeutics pose many di sadvantages due to their lack of specificity and low therapeutic index. To overcome these challenges, research has focused its attention on the development of nano-based delivery systems that can penetrate the leaky vasculature of tumor endothelium, use site-directed ligands that can bind with high affinity and specific ity to tumor cells, physically entrap poorly soluble drugs, and deliver these cytotoxic agents directly to the tumor site. One approach to nanosystem drug delivery is with the use of peptide amphiphiles (PAs) that are conjugated with the A
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Massaro, Raffaele <1988&gt. "Interaction of Glycoproteins H/L from human α-herpesviruses with αvβ integrins". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amsdottorato.unibo.it/7967/1/raffaele_massaro_tesi.pdf.

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Herpes Simplex Virus (HSV) and Varicella-Zoster Virus (VZV) belong to the viral subfamily Alphaherpesvirinae, and are important neurotropic human pathogens. HSV and VZV fuse their envelope with the membrane of the host cell, a process termed cell entry, accomplished by a conserved trio of viral glycoproteins (gB, gH and gL). Host cell receptors mediate viral entry, i.e. nectin1 is recognized by the viral tropism factor gD in HSV, while the host receptor is still elusive in VZV. Integrins are widely distributed adhesion membrane proteins, and give critical contribution to the entry of most huma
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Ellison, Timothy. "Elucidating how αvβ3-integrin regulates neuropilin-1's role in tumour angiogenesis in order to improve anti-angiogenic therapy". Thesis, University of East Anglia, 2015. https://ueaeprints.uea.ac.uk/57412/.

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αvβ3-integrin expression is vastly upregulated in tumour vasculature, and has long been considered a key molecule in promoting tumour angiogenesis. However, its initial promise as a target in anti-angiogenic therapy has wavered since the αvβ3-integrin antagonist cilengitide did not meet its end point in Phase III clinical trials for the treatment of glioblastoma. This failure corresponds with the enhanced tumour growth and angiogenesis observed in β3-integrin-knockout mice, which potentially occurs via a compensatory upregulation of VEGFR2 and enhancement in VEGFR2-neuropilin-1 interactions. H
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Lidén, Åsa. "Integrin αVβ3-Directed Contraction by Connective Tissue Cells : Role in Control of Interstitial Fluid Pressure and Modulation by Bacterial Proteins". Doctoral thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6601.

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<p>This thesis aimed at studying mechanisms involved in control of tissue fluid homeostasis during inflammation.</p><p>The interstitial fluid pressure (P<sub>IF</sub>) is of importance for control of tissue fluid balance. A lowering of P<sub>IF</sub> <i>in vivo</i> will result in a transport of fluid from the circulation into the tissue, leading to edema. Loose connective tissues that surround blood vessels have an intrinsic ability to take up fluid and swell. The connective tissue cells exert a tension on the fibrous network of the tissues, thereby preventing the tissues from swelling. Under
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Broich, Kerstin [Verfasser]. "Importance of αvβ3 [alpha-v-beta-3] integrin in arteriogenesis in the peripheral circulation of the rabbit / eingereicht von Kerstin Broich". Gießen : DVG-Service, 2004. http://d-nb.info/972754466/34.

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Ribeiro, Lívia Carolina de Abreu. "Efeito da desintegrina recombinante DisBa-01 incorporada em micelas ou livre em células portando ou não a integrina αvβ3 /". Araraquara, 2013. http://hdl.handle.net/11449/108420.

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Orientador :Iracilda Zeppone Carlos<br>Banca: Danielle Cardoso Geraldo Maia<br>Banca: Márcia Antoniazi Michelin<br>Banca: Dagmar Ruth Stach-Machado<br>Banca: Leila Aparecida Chiavacci<br>Resumo: Introdução: a integrina αvβ3 causa adesão celular à vitronectina e está expressa em diversos tumores humanos, mas está em níveis muito reduzidos nos tecidos normais, sendo mais notável em células derivadas da medula óssea. A desintegrina recombinante DisBa-01 se liga à integrina αvβ3, inibindo a adesão celular à vitronectina. Apresenta também uma capacidade antimetastática in vivo e antitrombótica in v
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Ribeiro, Lívia Carolina de Abreu [UNESP]. "Efeito da desintegrina recombinante DisBa-01 incorporada em micelas ou livre em células portando ou não a integrina αvβ3". Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/108420.

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Made available in DSpace on 2014-08-13T14:50:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-10-10Bitstream added on 2014-08-13T18:01:11Z : No. of bitstreams: 1 000736177_20181010.pdf: 393728 bytes, checksum: e7efdc1d70357c8accce55f226b8cee1 (MD5) Bitstreams deleted on 2018-10-19T12:50:41Z: 000736177_20181010.pdf,. Added 1 bitstream(s) on 2018-10-19T12:51:40Z : No. of bitstreams: 1 000736177.pdf: 1699234 bytes, checksum: 7c74f9ca1ff900faa29c2fee3b7096f2 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Bolsa de estudos<br>Introdução: a integrina αvβ3 causa
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Müller, Martina Verfasser], Horst [Akademischer Betreuer] [Kessler, Ute [Akademischer Betreuer] Reuning та Steffen Johannes [Akademischer Betreuer] Glaser. "Impact of the Integrin αvβ3 Transmembrane Domain Sequence and the Cytoplasmic Contacts on Cell/Matrix Adhesiveness and Integrin-mediated Cell Signalling / Martina Müller. Gutachter: Ute Reuning ; Steffen Johannes Glaser. Betreuer: Horst Kessler". München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1019853611/34.

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Brunie, Leonora Verfasser], Ute [Akademischer Betreuer] Reuning, Ernst J. [Akademischer Betreuer] Rummeny та Barbara [Akademischer Betreuer] [Schmalfeldt. "Generation of integrin αvβ3 cytoplasmic and transmembrane domain mutants: characterisation of the impact of integrin conformation on human ovarian cancer cell proliferation / Leonora Brunie. Gutachter: Ute Reuning ; Ernst J. Rummeny ; Barbara Schmalfeldt. Betreuer: Ute Reuning". München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1031513906/34.

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Leoni, Valerio <1985&gt. "Role of αvβ3 – Integrin and TLR2 in the innate response to Herpes Simplex Virus infection and Delivery of retargeted oncolytic Herpes Simplex via carrier cells". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6464/1/Leoni_Valerio_tesi.pdf.

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In the first part of my thesis I studied the mechanism of initiation of the innate response to HSV-1. Innate immune response is the first line of defense set up by the cell to counteract pathogens infection and it is elicited by the activation of a number of membrane or intracellular receptors and sensors, collectively indicated as PRRs, Patter Recognition Receptors. We reported that the HSV pathogen-associated molecular patterns (PAMP) that activate Toll-like receptor 2 (TLR2) and lead to the initiation of innate response are the virion glycoproteins gH/gL and gB, which constitute the conserv
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Leoni, Valerio <1985&gt. "Role of αvβ3 – Integrin and TLR2 in the innate response to Herpes Simplex Virus infection and Delivery of retargeted oncolytic Herpes Simplex via carrier cells". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6464/.

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In the first part of my thesis I studied the mechanism of initiation of the innate response to HSV-1. Innate immune response is the first line of defense set up by the cell to counteract pathogens infection and it is elicited by the activation of a number of membrane or intracellular receptors and sensors, collectively indicated as PRRs, Patter Recognition Receptors. We reported that the HSV pathogen-associated molecular patterns (PAMP) that activate Toll-like receptor 2 (TLR2) and lead to the initiation of innate response are the virion glycoproteins gH/gL and gB, which constitute the conserv
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This, Sébastien. "Régulation des réponses immunitaires adaptives par l'intégrine αvβ8 - Implications pour l'immunité des muqueuses et la réponse humorale". Thesis, Lyon, 2020. http://www.theses.fr/2020LYSEN011.

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A la suite d’une infection, la capacité de l’hôte à produire une réponse immunitaire efficace et adaptée est cruciale pour se défendre et générer une réponse mémoire permettant de se protéger contre une future réinfection. En revanche, il est absolument nécessaire que cette réponse soit correctement régulée afin d’éviter sa persistante ou son activation incontrôlée pouvant mener au développement de maladies immunitaires. Le système immunitaire comprend un ensemble complexe de cellules et de molécules immunitaires. En particulier, la capacité des cellules immunitaires à produire et à répondre a
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Schmitz, Carla Regina. "Avaliação da Milk Fat Globule Epidermal Growth Factor 8 (MFG-E8), da integrina αvβ3 e da Leukemia Inhibitory Factor (LIF) na implantação embrionária humana : estudo em modelo in vitro e no endométrio de mulheres com e sem endometriose". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/131165.

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Base teórica: O processo de implantação do embrião no ser humano é extremamente complexo e, ao mesmo tempo, essencial para que a mulher possa engravidar. Neste processo, em que o endométrio precisa sofrer uma série de mudanças para tornar-se receptivo, a adequada expressão de MFG-E8 (milk fat globule epidermal growth factor 8), seu receptor a integrina αvβ3 e LIF (leukemia inhibitory factor) parecem ter um papel importante. Além do mais, mulheres com infertilidade e endometriose podem apresentar a falha de implantação como uma grande barreira para obter seu sucesso terapêutico. Objetivos: Aval
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Braeuer, Miriam [Verfasser], та Heidrun [Akademischer Betreuer] Potschka. "Komparative Evaluation der Tracer Avebetrin und Aquibeprin zur Detektion der Integrine α5β1 und αvβ3 als Prädiktionsmarker der Revaskularisierung nach akutem Herzinfarkt im Rattenmodell / Miriam Braeuer ; Betreuer: Heidrun Potschka". München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/116957212X/34.

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Geiger, Pamina Xenia Charlotte [Verfasser], Ute [Akademischer Betreuer] Reuning, Manfred [Akademischer Betreuer] Schmitt та Ernst J. [Akademischer Betreuer] Rummeny. "Einfluss des Metastasierungssuppressors KAI1 CD 82 auf das Integrin αvβ3-vermittelte Migrations- und spreading-Verhalten humaner Ovarialkarzinomzellen / Pamina Xenia Charlotte Geiger. Gutachter: Ute Reuning ; Manfred Schmitt ; Ernst J. Rummeny. Betreuer: Ute Reuning". München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1031512500/34.

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Upheber, Sina [Verfasser], Ute [Akademischer Betreuer] Reuning, Manfred [Akademischer Betreuer] Schmitt та Barbara [Akademischer Betreuer] Schmalfeldt. "Die Integrin αvβ3-vermittelte Migration humaner Ovarialkarzinomzellen als Funktion des Metastasierungssuppressors KAI1 (CD82) und seiner Splice-Variante sowie deren Interaktion mit dem Zell/Zell-Adhäsionsmolekül E-Cadherin / Sina Upheber. Gutachter: Barbara Schmalfeldt ; Manfred Schmitt. Betreuer: Ute Reuning ; Manfred Schmitt". München : Universitätsbibliothek der TU München, 2015. http://d-nb.info/1075595924/34.

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Héroux, Julie. "Des lapins watanabe au syndrome hyper IgE humain : caractérisation précoce de l'athérosclérose utilisant une probe optique ciblant l'integrin aVb3." Thesis, Grenoble, 2012. http://www.theses.fr/2012GRENS041/document.

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La détection précoce de l’athérosclérose, avant le développement de ses séquellespathologiques, comme l’infarctus du myocarde, l’angine ou l’accident cérébrauxvasculaire(ACV), représente un important défi au niveau de la médecine diagnostiqueactuelle. Malgré les récentes avances technologiques, les maladies cardiovasculairesdemeurent la principale cause de décès dans les pays occidentaux et la détection à unstage plus précoce s’avère nécessaire pour permettre une intervention thérapeutiqueadéquate. Notre étude se concentre sur la détection de l’athérosclérose, plusspécifiquement la vulnérabili
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Garcia, Fulle Maria Isabel. "Expression of αvβ6 integrin in the junctional epithelium". Thesis, 2005. http://hdl.handle.net/2429/16745.

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Cell-cell binding and cell-extracellular matrix adhesion is mediated by cell surface receptors known as integrins, which play important roles during wound healing. Junctional epithelium (JE) that links gingiva to tooth enamel mimics wound epithelium. The αvβ6 integrin is an epithelial integrin that is not normally expressed by oral gingival epithelium but is induced during wound healing, and has also been shown to be expressed in squamous cell carcinomas and in leukoplakia specimens. Furthermore, αvβ6 integrin can bind and activate transforming growth factor-β (TGF-β), suggesting a centr
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Al-Dahlawi, Salwa. "The role of αvβ6 integrin in epidermal wound healing". Thesis, 2004. http://hdl.handle.net/2429/15613.

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The αvβ6 integrin is an exclusively epithelial integrin that is highly expressed during fetal development. In adult tissue αvβ6 integrin is re-expressed during inflammation, carcinogenesis and in wound healing. The objective of this study was to investigate whether compromised wound healing by hydrocortisone treatment is altered in mice deficient or overexpressing the β6 subunit in comparison to wild type littermates. Three groups of age and sex matched mice were used; wild type (WT), β6 integrin deficient (β6√-), and human β6 integrin overexpressing transgenic mice (hβ6Fl). Each group
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Ching-HaoTsai та 蔡景皓. "Design of Integrin αvβ6 or αIIbβ3-specific Antagonists using Disintegrin Scaffolds". Thesis, 2018. http://ndltd.ncl.edu.tw/handle/t5nny9.

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碩士<br>國立成功大學<br>生物化學暨分子生物學研究所<br>106<br>Integrins are a family of heterodimeric receptors that are expressed on the surface of most cells, where they mediate cell-cell and cell-extracellular matrix interactions. Integrin αvβ6 is epithelial-specific and strongly induced during wound healing, inflammation and carcinogenesis. Integrin αIIbβ3 plays a critical role in platelet aggregation that is essential for hemostasis and thrombosis. It was reported that proteins with ARGDLXXL and KGD motifs can selectively bind to integrins αvβ6 and αIIbβ3, respectively. In this study, we propose to use rhodost
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Turaga, Ravi C. "PROAGIO (A PROTEIN DESIGNED TO TARGET INTEGRIN αVβ3)". 2017. http://scholarworks.gsu.edu/biology_diss/189.

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Large efforts have been made to target integrin αVβ3 of endothelial cells. We have successfully developed a new class of protein (Ref to as ProAgio) by rational protein design using a stable host protein, domain 1 of cell adhesion protein CD2. ProAgio is designed to target integrin αVβ3 at a novel site and induces angiogenic endothelial cell apoptosis by recruiting and activating caspase 8 to the cytoplasmic domain of the targeted integrins. Tests with tumor xenograft models show that ProAgio strongly inhibits tumor growth. Histology analyses indicate that tumor vessels are reduced, while the
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Lössner, Daniela [Verfasser]. "Tumorbiologische Rolle des Integrins αvβ3 [Alpha-v-Beta-3] beim humanen Ovarialkarzinom : differentielle Genexpression des Epidermal-growth-factor-Receptors (EGF-R) und der Integrin-linked-Kinase (ILK) als Funktion des Integrins αvβ3 ; Evaluierung der Bindung spezifischer Integrin-Antagonisten mittels Oberflächenplasmonenspektroskopie / Daniela Lössner". 2007. http://d-nb.info/988098326/34.

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Hsieh, I.-Shan, та 謝宜珊. "Role of αvβ3 integrin in the action of osteopontin in cancer cells". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/c3z7nn.

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博士<br>國立臺灣大學<br>藥理學研究所<br>103<br>Osteopontin, known as a secreted phosphoprotein, has a functional RGD domain and acts as a regulator of cytoskeleton dynamics and gene expression. Extracellular osteopontin functions through its interaction with cell surface receptors, including various integrins (αvβ1, αvβ3, αvβ5, α4β1, and α9β1) and CD44. Binding of osteopontin to these receptors can elicit a wild range of functions, such as cell adhesion, survival, and migration. Osteopontin is overexpressed in various cancers and has a crucial role in all stages of cancer. Elevated ostoepontin has been corr
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chen, Tsai-kun, та 陳蔡昆. "The Role of the RXDDL Motif of Rhodostomin in Recognizing Integrin αVβ3". Thesis, 2007. http://ndltd.ncl.edu.tw/handle/98544917370609495610.

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碩士<br>國立成功大學<br>生物化學研究所<br>95<br>Integrins are heterodimeric cell surface receptors required for cell trafficking and for adhesion to other cell types and to constituents of the extracellular matrix. The ligands of integrins utilize RGD, ILDV, or short sequences as a key structural component for their integrin-binding site. Disintegrins are a family of RGD-containing and cysteine-rich proteins isolated from snake venoms. Many reports show that the RGD motif and the amino acid residues flanking the RGD sequence of disintgrins play an important role in recognizing integrins. They mainly interact
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Τσιουπινάκη, Κωνσταντία. "Molecular imaging of spatio-temporal distribution of angiogenesis in hindlimb ischemia model and diabetic milieu." Thesis, 2013. http://hdl.handle.net/10889/7944.

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In the current thesis, spatio-temporal evaluation of the endogenous angiogenic response to ischemia was perfomed. After vascular occlusion, ischemic angiogenesis is an important reparative mechanism and can ameliorate the outcome of ischemic disease. Diabetic foot ulcers affect almost 15% of diabetic patients and are the leading cause of amputations worldwide (Yoon et al., 2005). Diminished blood flow because of atherosclerotic occlusive disease of the peripheral arteries of diabetic patients, in conjunction with anatomic and functional microcirculatory impairments contribute to development of
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Kym, Eugene Yongshik (Gene). "Engineered Discoidin Domain from Factor VIII Binds αvβ3 Integrin with Antibody-like Affinity". Thesis, 2014. https://thesis.library.caltech.edu/8449/1/Gene_Kym_Thesis.pdf.

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Alternative scaffolds are non-antibody proteins that can be engineered to bind new targets. They have found useful niches in the therapeutic space due to their smaller size and the ease with which they can be engineered to be bispecific. We sought a new scaffold that could be used for therapeutic ends and chose the C2 discoidin domain of factor VIII, which is well studied and of human origin. Using yeast surface display, we engineered the C2 domain to bind to αvβ3 integrin with a 16 nM affinity while retaining its thermal stability and monomeric nature. We obtained a crystal structure of the e
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