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Zeitschriftenartikel zum Thema „Whirlin“

Autor: Grafiati

Veröffentlicht am 25. Mai 2024

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1

Zou, Junhuang, Ling Luo, Zuolian Shen, Vince A. Chiodo, Balamurali K. Ambati, William W. Hauswirth und Jun Yang. „Whirlin Replacement Restores the Formation of the USH2 Protein Complex in Whirlin Knockout Photoreceptors“. Investigative Opthalmology & Visual Science 52, Nr. 5 (12.04.2011): 2343. http://dx.doi.org/10.1167/iovs.10-6141.

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2

Hurtley, S. M. „CELL BIOLOGY: Whirlin to the Tip“. Science 307, Nr. 5709 (28.01.2005): 485c. http://dx.doi.org/10.1126/science.307.5709.485c.

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3

Ciardo, Maria Grazia, Amparo Andrés-Bordería, Natalia Cuesta, Pierluigi Valente, María Camprubí-Robles, Jun Yang, Rosa Planells-Cases und Antonio Ferrer-Montiel. „Whirlin increases TRPV1 channel expression and cellular stability“. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863, Nr. 1 (Januar 2016): 115–27. http://dx.doi.org/10.1016/j.bbamcr.2015.10.016.

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4

Oetke, Svenja, Axel J. Scheidig und Karin Krupinska. „WHIRLY1 of Barley and Maize Share a PRAPP Motif Conferring Nucleoid Compaction“. Plant and Cell Physiology 63, Nr. 2 (11.11.2021): 234–47. http://dx.doi.org/10.1093/pcp/pcab164.

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Abstract WHIRLY1 in barley was shown to be a major architect of plastid nucleoids. Its accumulation in cells of Escherichia coli coincided with an induction of nucleoid compaction and growth retardation. While WHIRLY1 of maize had similar effects on E. coli cells, WHIRLY1 proteins of Arabidopsis and potato as well as WHIRLY2 proteins had no impact on nucleoid compaction in E. coli. By mutagenesis of HvWHIRLY1 the PRAPP motif at the N-terminus preceding the highly conserved WHIRLY domain was identified to be responsible for the nucleoid compacting activity of HvWHIRLY1 in bacteria. This motif is found in WHIRLY1 proteins of most members of the Poaceae family, but neither in the WHIRLY2 proteins of the family nor in any WHIRLY protein of eudicot species such as Arabidopsis thaliana. This finding indicates that a subset of the monocot WHIRLY1 proteins has acquired a specific function as nucleoid compacters by sequence variation in the N-terminal part preceding the conserved WHIRLY domain and that in different groups of higher plants the compaction of nucleoids is mediated by other proteins.

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5

Prosser, Haydn M., Agnieszka K. Rzadzinska, Karen P. Steel und Allan Bradley. „Mosaic Complementation Demonstrates a Regulatory Role for Myosin VIIa in Actin Dynamics of Stereocilia“. Molecular and Cellular Biology 28, Nr. 5 (26.12.2007): 1702–12. http://dx.doi.org/10.1128/mcb.01282-07.

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ABSTRACT We have developed a bacterial artificial chromosome transgenesis approach that allowed the expression of myosin VIIa from the mouse X chromosome. We demonstrated the complementation of the Myo7a null mutant phenotype producing a fine mosaic of two types of sensory hair cells within inner ear epithelia of hemizygous transgenic females due to X inactivation. Direct comparisons between neighboring auditory hair cells that were different only with respect to myosin VIIa expression revealed that mutant stereocilia are significantly longer than those of their complemented counterparts. Myosin VIIa-deficient hair cells showed an abnormally persistent tip localization of whirlin, a protein directly linked to elongation of stereocilia, in stereocilia. Furthermore, myosin VIIa localized at the tips of all abnormally short stereocilia of mice deficient for either myosin XVa or whirlin. Our results strongly suggest that myosin VIIa regulates the establishment of a setpoint for stereocilium heights, and this novel role may influence their normal staircase-like arrangement within a bundle.

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6

Lin, Bisen, und K. Ravi-Chandar. „An Experimental Investigation of the Motion of Flexible Strings: Whirling“. Journal of Applied Mechanics 73, Nr. 5 (13.12.2005): 842–51. http://dx.doi.org/10.1115/1.2172270.

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Whirling of strings has been studied both theoretically and experimentally for many decades. According to linear theory, a heavy string can exhibit steady-state whirl only at its natural frequencies which form a discrete spectrum. The nonlinear theory, however, suggests that a string can undergo steady whirl at any frequency larger than the fundamental frequency and further that for each frequency between the nth and the (n+1)th eigenvalue, there exist n distinct whirling modes. Quantitative experimental observations on such whirling have never been reported, although anecdotal evidence suggests the possibility of such whirl. In this paper, we examine the whirling of a string with negligible bending stiffness through experiments utilizing a stereo-vision imaging system. It is shown that steady motion exists only when the string whirls at its natural frequencies and that whirling motions for other frequencies exhibit rich dynamics that needs further exploration.

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7

Mogensen, Mette M., Agnieszka Rzadzinska und Karen P. Steel. „The deaf mouse mutant whirler suggests a role for whirlin in actin filament dynamics and stereocilia development“. Cell Motility and the Cytoskeleton 64, Nr. 7 (2007): 496–508. http://dx.doi.org/10.1002/cm.20199.

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8

Delhommel, Florent, Florence Cordier, Frederick Saul, Lucas Chataigner, Ahmed Haouz und Nicolas Wolff. „Structural plasticity of the HHD 2 domain of whirlin“. FEBS Journal 285, Nr. 20 (05.09.2018): 3738–52. http://dx.doi.org/10.1111/febs.14614.

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9

Gautier, Candice, Francesca Troilo, Florence Cordier, Francesca Malagrinò, Angelo Toto, Lorenzo Visconti, Yanlei Zhu, Maurizio Brunori, Nicolas Wolff und Stefano Gianni. „Hidden kinetic traps in multidomain folding highlight the presence of a misfolded but functionally competent intermediate“. Proceedings of the National Academy of Sciences 117, Nr. 33 (03.08.2020): 19963–69. http://dx.doi.org/10.1073/pnas.2004138117.

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Although more than 75% of the proteome is composed of multidomain proteins, current knowledge of protein folding is based primarily on studies of isolated domains. In this work, we describe the folding mechanism of a multidomain tandem construct comprising two distinct covalently bound PDZ domains belonging to a protein called Whirlin, a scaffolding protein of the hearing apparatus. In particular, via a synergy between NMR and kinetic experiments, we demonstrate the presence of a misfolded intermediate that competes with productive folding. In agreement with the view that tandem domain swapping is a potential source of transient misfolding, we demonstrate that such a kinetic trap retains native-like functional activity, as shown by the preserved ability to bind its physiological ligand. Thus, despite the general knowledge that protein misfolding is intimately associated with dysfunction and diseases, we provide a direct example of a functionally competent misfolded state. Remarkably, a bioinformatics analysis of the amino acidic sequence of Whirlin from different species suggests that the tendency to perform tandem domain swapping between PDZ1 and PDZ2 is highly conserved, as demonstrated by their unexpectedly high sequence identity. On the basis of these observations, we discuss on a possible physiological role of such misfolded intermediate.

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10

Lin, Lin, Yingdong Shi, Mengli Wang, Chao Wang, Qing Lu, Jinwei Zhu und Rongguang Zhang. „Phase separation-mediated condensation of Whirlin-Myo15-Eps8 stereocilia tip complex“. Cell Reports 34, Nr. 8 (Februar 2021): 108770. http://dx.doi.org/10.1016/j.celrep.2021.108770.

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11

Zou, Junhuang, Amy Lee und Jun Yang. „The expression of whirlin and Cav1.3α1 is mutually independent in photoreceptors“. Vision Research 75 (Dezember 2012): 53–59. http://dx.doi.org/10.1016/j.visres.2012.07.020.

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12

de Nooij, J. C., C. M. Simon, A. Simon, S. Doobar, K. P. Steel, R. W. Banks, G. Z. Mentis, G. S. Bewick und T. M. Jessell. „The PDZ-Domain Protein Whirlin Facilitates Mechanosensory Signaling in Mammalian Proprioceptors“. Journal of Neuroscience 35, Nr. 7 (18.02.2015): 3073–84. http://dx.doi.org/10.1523/jneurosci.3699-14.2015.

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13

Kanemori, Yuji, und Takuzo Iwatsubo. „Forces and Moments Due to Combined Motion of Conical and Cylindrical Whirls for a Long Seal“. Journal of Tribology 116, Nr. 3 (01.07.1994): 489–98. http://dx.doi.org/10.1115/1.2928871.

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The mutual interaction effects of cylindrical and conical whirl on the dynamic fluid forces and moments, which act on a long annular seal, were studied experimentally. A whirling motion composed of cylindrical and conical whirls is actuated by intentionally giving the phase difference between the seal exit and inlet whirling movements. This whirling motion is believed to generate during actual pump running. The experiment was conducted by changing the phase difference, at various rotor speeds and with a pressure difference between the seal inlet and exit. The result of this study revealed that fluid forces and moments are greatly dependent on the phase difference of the whirl, namely the long seal has a significant coupling between displacements and rotations. Furthermore, dynamic fluid forces and moments were derived theoretically, assuming that total fluid force acting on the rotor could be determined by superposing fluid forces due to conical and cylindrical whirling movements. It was confirmed that the experimental results moderately agree with the theoretical values, if the rotor and seal are set in concentric alignment, the principle of superposition becomes applicable.

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14

Mburu, Philomena, Mirna Mustapha, Anabel Varela, Dominique Weil, Aziz El-Amraoui, Ralph H. Holme, Andreas Rump et al. „Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31“. Nature Genetics 34, Nr. 4 (29.06.2003): 421–28. http://dx.doi.org/10.1038/ng1208.

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15

Mburu, P., Y. Kikkawa, S. Townsend, R. Romero, H. Yonekawa und S. D. M. Brown. „Whirlin complexes with p55 at the stereocilia tip during hair cell development“. Proceedings of the National Academy of Sciences 103, Nr. 29 (07.07.2006): 10973–78. http://dx.doi.org/10.1073/pnas.0600923103.

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16

Ebrahim, Seham, Neil J. Ingham, Morag A. Lewis, Michael J. C. Rogers, Runjia Cui, Bechara Kachar, Johanna C. Pass und Karen P. Steel. „Alternative Splice Forms Influence Functions of Whirlin in Mechanosensory Hair Cell Stereocilia“. Cell Reports 15, Nr. 5 (Mai 2016): 935–43. http://dx.doi.org/10.1016/j.celrep.2016.03.081.

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17

Ding, Chao, Lingfeng He, Zijian Yan, Yuyao Li, Shuangyang Ma und Yan Jiao. „Experimental Investigation on the Impact of Varying Air-Inlet Widths and Fuel Pan Diameters on Fire Whirls’ Combustion Characteristics“. Fire 6, Nr. 8 (10.08.2023): 309. http://dx.doi.org/10.3390/fire6080309.

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A fire whirl, a unique fire behavior, occurs when a vertical vortex of flames skyrockets due to specific surrounding temperatures and thermal gradient conditions during a fire. Compared with conventional fire plumes, fire whirls exhibit a higher air entrainment rate, tangential velocity, and axial velocity, thus presenting greater risks and destructive capabilities. Thus, studying the combustion characteristics of fire whirls becomes necessary. This experiment employed a small-scale, fixed-frame fire whirl generator. We investigated how varying air-inlet widths and fuel pan diameters influence the fire whirl’s combustion characteristics. Experimental images indicated a negative correlation between the fire whirl’s flame height and the air-inlet width, and a positive correlation with the fuel pan diameter. Our findings showed that the burning rate of the fire whirl during the quasi-steady-state combustion phase initially increased and then decreased as the air-inlet width expanded, peaking at a width of 7 cm. The data demonstrated a corresponding power-law relationship between the fire whirl’s dimensionless flame height and excess temperature. Ultimately, our results indicated a positive correlation between the 2/5 power of the fire whirl’s dimensionless heat release rate and the dimensionless flame height. The ratios of maximum to mean flame height and mean to continuous flame height are 1.35 and 1.5, respectively. Significantly, these ratios remain unaffected by the air-inlet width, fuel pan diameter, environmental temperature, and heat release rate.

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18

Wright, Rachel N., Dong-Hyun Hong und Brian Perkins. „RpgrORF15Connects to the Usher Protein Network through Direct Interactions with Multiple Whirlin Isoforms“. Investigative Opthalmology & Visual Science 53, Nr. 3 (21.03.2012): 1519. http://dx.doi.org/10.1167/iovs.11-8845.

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19

Schellens, R. T. W., R. W. N. Slijkerman, L. Hetterschijt, T. A. Peters, S. Broekman, A. Clemént, M. Westerfield et al. „Affinity purification of in vivo assembled whirlin-associated protein complexes from the zebrafish retina“. Journal of Proteomics 266 (August 2022): 104666. http://dx.doi.org/10.1016/j.jprot.2022.104666.

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20

Kikkawa, Yoshiaki, Philomena Mburu, Sue Morse, Ryo Kominami, Stuart Townsend und Steve D. M. Brown. „Mutant analysis reveals whirlin as a dynamic organizer in the growing hair cell stereocilium“. Human Molecular Genetics 14, Nr. 3 (08.12.2004): 391–400. http://dx.doi.org/10.1093/hmg/ddi035.

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21

Tuppini, Tommaso. „La sensazione e il vortice del sonno“. Chiasmi International 22 (2020): 385–97. http://dx.doi.org/10.5840/chiasmi20202234.

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We typically conceive of sensation as a residue of empiricism and idealism, both of which claim to reduce our experience to a sum of elementary data that the subject encounters. For Merleau-Ponty, sensation is none of these things: it defines our ability to let ourselves be solicited by the relief and questions of the world. What is sensed is not an inert datum but a gesture of existence that concerns me, invites me to correspond to it and follow it. When I respond to the invitations of what I sense, the connection between me and the world functions as the immobile axis around which the whirls of a whirlwind are formed. Whirlwind of sensation or whirlwind of sleep, because sensing is also made of a night time-space in which the connection with things seem to be broken. The inertia of sleep is whirling in its own way, just as the dynamism of sensation has its own condition of possibility in an immeasurable measure of apathy and indifference.

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22

Chung, Joseph D., Xiao Zhang, Carolyn R. Kaplan und Elaine S. Oran. „The structure of the blue whirl revealed“. Science Advances 6, Nr. 33 (August 2020): eaba0827. http://dx.doi.org/10.1126/sciadv.aba0827.

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The blue whirl is a small, stable, spinning blue flame that evolved spontaneously in recent laboratory experiments while studying turbulent, sooty fire whirls. It burns a range of different liquid hydrocarbon fuels cleanly with no soot production, presenting a previously unknown potential way for low-emission combustion. Here, we use numerical simulations to present the flame and flow structure of the blue whirl. These simulations show that the blue whirl is composed of three different flames—a diffusion flame and premixed rich and lean flames—all of which meet in a fourth structure, a triple flame that appears as a whirling blue ring. The results also show that the flow structure emerges as the result of vortex breakdown, a fluid instability that occurs in swirling flows. These simulations are a critical step forward in understanding how to use this previously unknown form of clean combustion.

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23

Delhommel, Florent, Florence Cordier, Benjamin Bardiaux, Guillaume Bouvier, Baptiste Colcombet-Cazenave, Sébastien Brier, Bertrand Raynal et al. „Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem“. Structure 25, Nr. 11 (November 2017): 1645–56. http://dx.doi.org/10.1016/j.str.2017.08.013.

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24

Green, James A., Jun Yang, M’hamed Grati, Bechara Kachar und Manzoor A. Bhat. „Whirlin, a cytoskeletal scaffolding protein, stabilizes the paranodal region and axonal cytoskeleton in myelinated axons“. BMC Neuroscience 14, Nr. 1 (2013): 96. http://dx.doi.org/10.1186/1471-2202-14-96.

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25

Belyantseva, Inna A., Erich T. Boger, Sadaf Naz, Gregory I. Frolenkov, James R. Sellers, Zubair M. Ahmed, Andrew J. Griffith und Thomas B. Friedman. „Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia“. Nature Cell Biology 7, Nr. 2 (16.01.2005): 148–56. http://dx.doi.org/10.1038/ncb1219.

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26

Yang, Jun, Xiaoqing Liu, Yun Zhao, Michael Adamian, Basil Pawlyk, Xun Sun, D. Randy McMillan, M. Charles Liberman und Tiansen Li. „Ablation of Whirlin Long Isoform Disrupts the USH2 Protein Complex and Causes Vision and Hearing Loss“. PLoS Genetics 6, Nr. 5 (20.05.2010): e1000955. http://dx.doi.org/10.1371/journal.pgen.1000955.

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27

Manor, Uri, Andrea Disanza, M'Hamed Grati, Leonardo Andrade, Harrison Lin, Pier Paolo Di Fiore, Giorgio Scita und Bechara Kachar. „Regulation of Stereocilia Length by Myosin XVa and Whirlin Depends on the Actin-Regulatory Protein Eps8“. Current Biology 21, Nr. 2 (Januar 2011): 167–72. http://dx.doi.org/10.1016/j.cub.2010.12.046.

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28

Delhommel, Florent, Nicolas Wolff und Florence Cordier. „1H, 13C and 15N backbone resonance assignments and dynamic properties of the PDZ tandem of Whirlin“. Biomolecular NMR Assignments 10, Nr. 2 (09.07.2016): 361–65. http://dx.doi.org/10.1007/s12104-016-9701-z.

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29

Jiang, Yuting, Qi Sun, Meihua Fan, Xiaolin Zhang, Wang Shen, Huanzhi Xu und Zhi Liao. „Molecular characterization of a whirlin-like protein with biomineralization-related functions from the shell of Mytilus coruscus“. PLOS ONE 15, Nr. 4 (08.04.2020): e0231414. http://dx.doi.org/10.1371/journal.pone.0231414.

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30

Delhommel, Florent, Florence Cordier, Bertrand Raynal, Amel El Bahloul-Jaziri, Christine Petit, Muriel Delepierre und Nicolas Wolff. „Structural Study of Whirlin, A Crucial PDZ Containing Protein Involved in the Mechanotransduction of Auditory Hair Cells“. Biophysical Journal 110, Nr. 3 (Februar 2016): 319a. http://dx.doi.org/10.1016/j.bpj.2015.11.1713.

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31

Kersten, Ferry F. J., Erwin van Wijk, Jeroen van Reeuwijk, Bert van der Zwaag, Tina Märker, Theo A. Peters, Nicholas Katsanis et al. „Association of Whirlin with Cav1.3 (α1D) Channels in Photoreceptors, Defining a Novel Member of the Usher Protein Network“. Investigative Opthalmology & Visual Science 51, Nr. 5 (01.05.2010): 2338. http://dx.doi.org/10.1167/iovs.09-4650.

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32

Zhu, Yanlei, Florent Delhommel, Florence Cordier, Susanne Lüchow, Ariel Mechaly, Baptiste Colcombet-Cazenave, Virginie Girault et al. „Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners“. Journal of Molecular Biology 432, Nr. 22 (November 2020): 5920–37. http://dx.doi.org/10.1016/j.jmb.2020.09.012.

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33

Mathur, Pranav Dinesh, und Jun Yang. „Usher syndrome and non-syndromic deafness: Functions of different whirlin isoforms in the cochlea, vestibular organs, and retina“. Hearing Research 375 (April 2019): 14–24. http://dx.doi.org/10.1016/j.heares.2019.02.007.

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34

Saifetiarova, Julia, und Manzoor A. Bhat. „Ablation of cytoskeletal scaffolding proteins, Band 4.1B and Whirlin, leads to cerebellar purkinje axon pathology and motor dysfunction“. Journal of Neuroscience Research 97, Nr. 3 (17.11.2018): 313–31. http://dx.doi.org/10.1002/jnr.24352.

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35

Ohashi, H., und H. Shoji. „Lateral Fluid Forces on Whirling Centrifugal Impeller (2nd Report: Experiment in Vaneless Diffuser)“. Journal of Fluids Engineering 109, Nr. 2 (01.06.1987): 100–106. http://dx.doi.org/10.1115/1.3242628.

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Fluid forces acting on a rotating centrifugal impeller in whirling motion are studied experimentally. A two-dimensional impeller installed in a parallel walled vaneless diffuser was forced on a circular orbital motion at various positive and negative whirl speeds. The measurements show that the fluid forces exert a damping effect on the rotor at most operating conditions, but excite positive whirl when the impeller operates at a partial discharge and rotates at speeds more than twice the whirl speed. The test results were compared with those calculated by the theory described in the 1st Report. The characteristics of whirling fluid forces are examined from both the measurements and calculations. The measured fluid forces are expressed in terms of mass, damping, and stiffness matrices.

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36

Huo, Yan, Ye Gao und De Xiang Huang. „Numerical Simulation of Internal Fire Whirls in an Inclined Shaft“. Advanced Materials Research 732-733 (August 2013): 254–57. http://dx.doi.org/10.4028/www.scientific.net/amr.732-733.254.

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In order to understand the characteristics of fire whirls in the inclined shaft with corner gap, large eddy simulations (LES) of thermal flow field in a 9-meter-high inclined shaft were employed. In the inclined shaft, the conrner gap is 0.3m and 0.7m in width, and the inclination angle is 5°, 30°, 45°, 50° and 55° from the vertical orientation axes respectively. It is found that a whirling flow field could be formed under proper inclination angles and corner gap width. Rotational axis of fire whirls in the inclined shaft would have same inclination angles with the shaft. Similar to the case of fire whirls in a vertical shaft, the width of corner gap of inclined shaft also influences the whirling motion of the flame. In this paper, for the same fire and inclination angle, the 0.3-meter-wide corner gap is easier to form stable fire whirls than the 0.7-meter-wide corner gap. By comparison with buoyancy, the slightly greater Coriolis force was found above a height 3m for inclined fire whirls when the width of croner gap is 0.3m, however, the Coriolis force acts only on the lower part of the shaft when the width of croner gap is 0.7m.

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37

Wang, L., J. Zou, Z. Shen, E. Song und J. Yang. „Whirlin interacts with espin and modulates its actin-regulatory function: an insight into the mechanism of Usher syndrome type II“. Human Molecular Genetics 21, Nr. 3 (02.11.2011): 692–710. http://dx.doi.org/10.1093/hmg/ddr503.

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38

Mathur, Pranav Dinesh, Junhuang Zou, Tihua Zheng, Ali Almishaal, Yong Wang, Qian Chen, Le Wang et al. „Distinct expression and function of whirlin isoforms in the inner ear and retina: an insight into pathogenesis of USH2D andDFNB31“. Human Molecular Genetics 24, Nr. 21 (24.08.2015): 6213–28. http://dx.doi.org/10.1093/hmg/ddv339.

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39

Du, Haibo, Rui Ren, Panpan Chen, Zhigang Xu und Yanfei Wang. „Identification of Binding Partners of Deafness-Related Protein PDZD7“. Neural Plasticity 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/2062346.

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PDZD7 is an important deafness gene, whose mutations are associated with syndromic and nonsyndromic hearing loss. PDZD7 contains multiple PDZ domains that are essential for organizing various proteins into protein complex. Several PDZD7-binding proteins have been identified, including usherin, ADGRV1, whirlin, harmonin, SANS, and MYO7A, all belonging to USH proteins. Here, we report the identification of novel PDZD7-binding partners through yeast two-hybrid screening using the first two PDZ domains of PDZD7 as bait. Eleven proteins were identified, most of which have not been reported as PDZD7-binding partners before. Among the identified proteins, ADGRV1, gelsolin, and β-catenin have been shown to play important roles in hearing, whereas the functions of other proteins in the inner ear remain elusive. We confirmed the expression of one candidate PDZD7-binding protein, CADM1, in the mouse inner ear and evaluated the auditory function of Cadm1 knockout mice by performing auditory brainstem response (ABR) measurement. Unexpectedly, Cadm1 knockout mice show normal hearing threshold, which might be explained by the possible compensation by its homologs that are also expressed in the inner ear. Taken together, our work identified several novel PDZD7-binding proteins, which will help us to further understand the role of PDZD7 in hearing transduction.

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40

Li, Jianchao, Yunyun He, Meredith L. Weck, Qing Lu, Matthew J. Tyska und Mingjie Zhang. „Structure of Myo7b/USH1C complex suggests a general PDZ domain binding mode by MyTH4-FERM myosins“. Proceedings of the National Academy of Sciences 114, Nr. 19 (24.04.2017): E3776—E3785. http://dx.doi.org/10.1073/pnas.1702251114.

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Unconventional myosin 7a (Myo7a), myosin 7b (Myo7b), and myosin 15a (Myo15a) all contain MyTH4-FERM domains (myosin tail homology 4-band 4.1, ezrin, radixin, moesin; MF) in their cargo binding tails and are essential for the growth and function of microvilli and stereocilia. Numerous mutations have been identified in the MyTH4-FERM tandems of these myosins in patients suffering visual and hearing impairment. Although a number of MF domain binding partners have been identified, the molecular basis of interactions with the C-terminal MF domain (CMF) of these myosins remains poorly understood. Here we report the high-resolution crystal structure of Myo7b CMF in complex with the extended PDZ3 domain of USH1C (a.k.a., Harmonin), revealing a previously uncharacterized interaction mode both for MyTH4-FERM tandems and for PDZ domains. We predicted, based on the structure of the Myo7b CMF/USH1C PDZ3 complex, and verified that Myo7a CMF also binds to USH1C PDZ3 using a similar mode. The structure of the Myo7b CMF/USH1C PDZ complex provides mechanistic explanations for >20 deafness-causing mutations in Myo7a CMF. Taken together, these findings suggest that binding to PDZ domains, such as those from USH1C, PDZD7, and Whirlin, is a common property of CMFs of Myo7a, Myo7b, and Myo15a.

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Merticaru, Vasile, Gheorghe Nagîț, Oana Dodun, Eugen Merticaru, Marius Ionuț Rîpanu, Andrei Marius Mihalache und Laurențiu Slătineanu. „Influence of Machining Conditions on Micro-Geometric Accuracy Elements of Complex Helical Surfaces Generated by Thread Whirling“. Micromachines 13, Nr. 9 (14.09.2022): 1520. http://dx.doi.org/10.3390/mi13091520.

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Complex surfaces such as helical ones are commonly used in machinery. Such surfaces can be obtained by various machining processes, one of these processes being thread whirling. The influence of machining conditions needs to be better understood to develop a more precise prediction of the specific resulting errors involved in thread whirling. This paper firstly presents the theoretical conditions which generate micro-deviations on whirled surfaces. A theoretical model which considers the geometrical parameters describing the whirling head and cutters and the process’s whole kinematics was developed. The threaded surface was described as a complex compound surface resulting from intersecting successive ruled helical surfaces corresponding to the cutting edges of the set of cutters from the whirling head. Numerical simulation results were exemplified and validation experiments were both designed and performed. Empirical mathematical models were established to highlight the influence of the input factors such as thread pitch and external diameter, the ratio between the diameter of cutters’ top edge disposal and the thread’s external diameter, the rotary speed of the whirling head, and the rotary speed of the workpiece on some accuracy elements and roughness parameters of the threaded surface.

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Tsujimoto, Y., A. J. Acosta und C. E. Brennen. „Theoretical Study of Fluid Forces on a Centrifugal Impeller Rotating and Whirling in a Volute“. Journal of Vibration and Acoustics 110, Nr. 3 (01.07.1988): 263–69. http://dx.doi.org/10.1115/1.3269512.

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Fluid forces on a rotating and whirling centrifugal impeller in a volute are analyzed with the assumption of a two-dimensional rotational, inviscid flow. For simplicity, the flow is assumed to be perfectly guided by the impeller vanes. The theory predicts the tangential and the radial force on the whirling impeller as functions of impeller geometry, volute spacing, and whirl ratio. A good qualitative agreement with experiment is found.

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Xie, Jingsong, Jinglong Chen, Yizhen Peng und Yanyang Zi. „A New Concept of Instantaneous Whirling Speed for Cracked Rotor’s Axis Orbit“. Applied Sciences 9, Nr. 19 (02.10.2019): 4120. http://dx.doi.org/10.3390/app9194120.

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At present, the axis orbit (whirling) and the instantaneous angular speed (spinning) are important symptoms in the condition monitoring of rotor systems. However, because of the lack of research of the transient characteristics of axis orbit within a whirl cycle, the axis orbit cannot reflect the instantaneous characteristics of the rotation during one whirling cycle like the instantaneous angular speed. Therefore, in this paper, a new concept of instantaneous whirling speed of axis orbit within a whirling cycle is proposed and defined. In addition, the transient characteristics of instantaneous whirling speed are studied. Meanwhile, the response mechanisms are qualitative analyzed through the study of the work of the additional stiffness excitation and the conversion relationship between the kinetic energy and the potential energy. Then, the minimum of the relative instantaneous whirling speed (RWS) is proposed as a potential monitoring index for crack severity. The instantaneous whirling speed is a new attribute of axis orbit and a new perspective for the vibration analysis of cracked rotors. The addition of this new attribute significantly increases the effect of axis orbit for distinguishing normal and cracked rotors. The new analysis perspective and the new diagnosis index are potential supplements for crack diagnosis.

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Shoji, H., und H. Ohashi. „Lateral Fluid Forces on Whirling Centrifugal Impeller (1st Report: Theory)“. Journal of Fluids Engineering 109, Nr. 2 (01.06.1987): 94–99. http://dx.doi.org/10.1115/1.3242647.

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Lateral fluid forces acting on a rotating centrifugal impeller in whirling motion are analyzed using unsteady potential flow theory. Impellers operating in diffusers with and without vanes are modeled and the fluid forces calculated for different whirl speeds and flow rates. The influences of these parameters are clarified by parametric calculations. The results for whirling impellers operating in vaneless diffusers show that the fluid forces exert a damping effect on the rotor whirling motion at all operating conditions. The results for impellers operating in vaned diffusers or guide vanes show that the time averaged values of fluid forces remain almost unchanged, while there are significant instantaneous fluctuations due to the impeller/guide vane interactions.

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Yoshida, Yoshiki, Yoshinobu Tsujimoto, Nobuhiro Ishii, Hideo Ohashi und Fumitaka Kano. „The Rotordynamic Forces on an Open-Type Centrifugal Compressor Impeller in Whirling Motion“. Journal of Fluids Engineering 121, Nr. 2 (01.06.1999): 259–65. http://dx.doi.org/10.1115/1.2822200.

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In recent years, increasing interest has been given to the rotordynamic forces on impellers, from the view point of the shaft vibration analysis. Previous experimental and analytical results have shown that the fluid-induced forces on closed-type (with shroud) centrifugal impellers in whirling motion contribute substantially to the potential destabilization of subsynchronous shaft vibrations. However, to date nothing is known of the rotordynamic forces on open-type (without shroud) centrifugal impellers. This paper examines the rotordynamic fluid forces on an open-type centrifugal compressor impeller in whirling motion. For an open-type impeller, the variation of the tip clearance due to the whirling motion is the main contribute to the rotordynamic forces. Experiments were performed to investigate the rotordynamic forces by direct measurements using a force balance device, and indirectly from the unsteady pressure on the casing wall over a range of whirl speed ratio (Ω/ω) for several flow rates. In this paper, the following results were obtained: (1) Destabilizing forces occur at small positive whirl speed ratio (0 ≤ Ω/ω ≤ 0.3) throughout the flow range of normal operation; (2) At smaller flow rate with inlet backflow, the magnitude of the fluid force changes dramatically at a whirl speed ratio close to Ω/ω = 0.8, resulting in destabilizing rotordynamic forces. From the measurement of unsteady inlet pressure, it was shown that the drastic changes in the fluid force are related to the coupling of the whirling motion with a rotating flow instability, similar to “rotating stall”; (3) The forces estimated from the unsteady pressure distribution on the casing wall and those estimated from the pressure difference across the impeller blades were compared with the results from the direct fluid force measurements. The direct fluid forces correlate better with the forces due to the pressure distribution on the casing wall.

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Delprat, Benjamin, Vincent Michel, Richard Goodyear, Yasuhiro Yamasaki, Nicolas Michalski, Aziz El-Amraoui, Isabelle Perfettini et al. „Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly“. Human Molecular Genetics 14, Nr. 3 (08.12.2004): 401–10. http://dx.doi.org/10.1093/hmg/ddi036.

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Colding-Jorgensen, J. „Prediction of Rotor Dynamic Destabilizing Forces in Axial Flow Compressors“. Journal of Fluids Engineering 114, Nr. 4 (01.12.1992): 621–25. http://dx.doi.org/10.1115/1.2910076.

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It has been shown by Thomas (1958) and Alford (1965), that axial flow turbo-machinery is subject to rotor dynamic destabilizing gas forces produced by the circumferential variation of blade-tip clearance when the rotor is whirling. However, the magnitude and direction of these forces have yet to be clarified. For example, it is still uncertain, under which circumstances the rotor whirl direction will be forward, and when it will be backward, with respect to the rotation. In the present paper, a simple analysis of the perturbed flow in an axial compressor stage with whirling rotor is presented, based on the actuator disc analysis of Horlock and Greitzer (1983), and the gas force on the rotor is calculated on this basis. It appears that in the normal operation range of an axial compressor, the whirl direction is predicted to be forward always. Backward whirl is predicted to take place only at very low flow rates, well below the normally expected stall limit. Experimentally, forces were indeed found in direction of backward whirl for low flow rates, and in direction of forward whirl for high flow rates, in the results reported by Vance and Laudadio (1984), as analyzed by Ehrich (1989). While this experimental evidence supports the present theory qualitatively, a direct comparison of the measured and predicted destabilizing force has yet to be carried out.

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Yoshida, Yoshiki, Yoshinobu Tsujimoto, Goh Morimoto, Hiroki Nishida und Shigeki Morii. „Effects of Seal Geometry on Dynamic Impeller Fluid Forces and Moments“. Journal of Fluids Engineering 125, Nr. 5 (01.09.2003): 786–95. http://dx.doi.org/10.1115/1.1598988.

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This paper reports an experimental investigation of the rotordynamic fluid force and moment on a centrifugal impeller with three types of wear-ring seals; i.e., a face seal and two types of toothed seals. The impeller is equipped with a vaneless diffuser. Rotordynamic fluid forces and moments on the impeller in whirling motion were measured directly by using four-axis force sensor. Unsteady pressures were measured at several locations in the diffuser. It was found that, (1) at low flow rate, the fluid force and fluid force moment become maximum at a certain whirling speed caused by a coupling between the whirl motion and vaneless diffuser rotating stall and (2) the seal geometry with axial seal affects the direction of the coupled fluid force relative to the direction of eccentricity through the change in the unsteady leakage flow due to the whirl.

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Jiang, Jun. „The Analytical Solution and The Existence Condition of Dry Friction Backward Whirl in Rotor-to-Stator Contact Systems“. Journal of Vibration and Acoustics 129, Nr. 2 (20.04.2006): 260–64. http://dx.doi.org/10.1115/1.2345677.

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Dry friction backward whirl is a self-excited vibration state in rotor-to-stator contact systems, by which the rotor is in continuous contact with the stator, slipping continuously on the contact surface and whirling backward at a supersynchronous frequency. To correctly cope the response of dry friction backward whirl, the effect of dry friction must be taken into account in rotor/stator models. From the knowledge on the characteristics of dry friction backward whirl, the whirl frequency, the existence condition and the solution of this response are derived analytically in this paper. The analytical results are verified by simulations and shown in good correspondence to the experimental observations.

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Chen, Qian, Junhuang Zou, Zuolian Shen, Weiping Zhang und Jun Yang. „Whirlin and PDZ Domain-containing 7 (PDZD7) Proteins Are Both Required to Form the Quaternary Protein Complex Associated with Usher Syndrome Type 2“. Journal of Biological Chemistry 289, Nr. 52 (18.11.2014): 36070–88. http://dx.doi.org/10.1074/jbc.m114.610535.

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