Thematische Bibliographien / Western Presbyterian Church (Philadelphia, Pa.)

Auswahl der wissenschaftlichen Literatur zum Thema „Western Presbyterian Church (Philadelphia, Pa.)“

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Veröffentlicht am 25. Juli 2024

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Zeitschriftenartikel zum Thema "Western Presbyterian Church (Philadelphia, Pa.)"

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Marsden, George M. „Fighting the Good Fight: A Brief History of the Orthodox Presbyterian Church. By D. G. Hart and John Muether. Philadelphia, Pa.: Orthodox Presbyterian Church, 1995. 217 pp. $11.95.“ Church History 65, Nr. 4 (Dezember 1996): 771–73. http://dx.doi.org/10.2307/3170474.

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Wiley, Mark B., Jessica Bauer, Kunaal Mehrotra, David N. Church, Rachel S. Kerr, David J. Kerr, Paul Grippo und Barbara Jung. „Abstract B013: Activin’s influence on the tumor microenvironment in colon cancer“. Cancer Research 82, Nr. 23_Supplement_1 (01.12.2022): B013. http://dx.doi.org/10.1158/1538-7445.crc22-b013.

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Abstract Background and aims: Activin A (activin) is a key molecule that regulates cell specific and context dependent signaling in tumor growth and metastasis as well as local and systemic inflammatory responses. Understanding the link between tumor-promotive and inflammatory effects may provide a novel opportunity for targeted therapy in colorectal cancer (CRC). We have previously shown that activin signaling promotes epithelial to mesenchymal transition, tumor migration, and that serum activin correlates with advanced stage in CRC patients. Recently, activin has been implicated in enhancing CD4+ to CD8+ communications to promote cytotoxic elimination of tumor cells. We now hypothesize that activin exerts cell-specific effects in the tumor microenvironment (TME) to both promote anti-tumoral activity of immune cells and pro-metastatic behavior of tumor cells in a context-dependent manner. Methods: Western blot and transwell migration assays with and without activin were performed in human epithelial colon cancer cells with varying expression levels of ACVR2 and in human colonic fibroblasts. The influence of the canonical Smad4 pathway was elucidated in a Ts4-Cre;Apcflox;Smad4flox mouse model for CRC. We analyzed a TMA of 1055 stage II and III CRC patients from the QUASAR2 cohort to correlate activin and CD4+ expression with outcome. The TMAs were also analyzed via Digital Spatial Profiling (DSP, NanoString) to determine the immune cell heterogeneity and cell signaling patterns within the tumor microenvironment relative to activin. Results: The non-canonical pAkt pathway is activated in ACVR2-restored but not ACVR2-mutated HCT116+chr2 colon cancer cells, which leads to tumor cell migration in a PI3K-dependent manner. In vivo, ablation of downstream canonical SMAD signaling is associated with elevated activin, alpha-SMA and pAkt and increases in tissue dysplasia, intestinal stromal disorganization, and animal mortality. While there are direct pro-metastatic effects of activin on tumor cells, activin expression in the TME of stage II or III CRC patients is associated with elevated CD4 and survival benefit (High activin/high CD4: 1.665 hazard ratio, 95% Cl of ratio 1.379 to 2.010). DSP analysis confirmed co-localization of activin with immune cells in the TME which influences cell signaling patterns found in these regions. Conclusion: In colon cancer cells, activin leads to preferential prometastatic PI3K/Akt pathway activation. Within the TME, high levels of activin in the presence of CD4+ T-cells is associated with better outcomes in CRC patients. This work lays the foundation to further study context-dependent activin signaling as an adjunct or target in CRC. Citation Format: Mark B. Wiley, Jessica Bauer, Kunaal Mehrotra, David N. Church, Rachel S. Kerr, David J. Kerr, Paul Grippo, Barbara Jung. Activin’s influence on the tumor microenvironment in colon cancer [abstract]. In: Proceedings of the AACR Special Conference on Colorectal Cancer; 2022 Oct 1-4; Portland, OR. Philadelphia (PA): AACR; Cancer Res 2022;82(23 Suppl_1):Abstract nr B013.
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Smith, Thomas J., Louise M. Ryan, Harold O. Douglass, Daniel G. Haller, Yogeshwar Dayal, John Kirkwood, Douglas C. Tormey, Alan J. Schutt, Josephine Hinson und Benjamin Sischy. „Combined chemoradiotherapy vs. radiotherapy alone for early stage squamous cell carcinoma of the esophagus: a study of the eastern cooperative oncology group 11Other participating institutions: Albany Medical College, Albany, NY (CA 06594); Albert Einstein College of Medicine, Bronx, NY (CA 14958); University of California-Irvine, Orange, CA; Case Western Reserve University, Cleveland, OH (CA 14548); Chicago Medical School, Chicago, IL (CA 14144); Colorado Cancer Research Program, Denver, CO; Downstate Medical Center, Brooklyn, NY; University of Florida-Gainesville, Gainesville, FL; Fox Chase Cancer Center, Philadelphia, PA (CA 18281); Indiana University Medical Center, Indianapolis, IN (CA 49883); Medical College of Ohio, Toledo, OH; University of Medicine and Dentistry of New Jersey, Newark, NJ; University of Minnesota, Minneapolis, MN (CA 20365); New York University Medical Center, New York, NY (CA 16395); Newark Beth Israel Medical Center, Newark, NJ; Rush-Presbyterian-St. Luke’s Medical Center, Chicago, IL (CA 25988); University of Pretoria, Pretoria, South Africa (CA 21692); Natalie Warren Bryant Cancer Center, Tulsa, OK; Vermont Regional Cancer Center, Burlington, VT.“ International Journal of Radiation Oncology*Biology*Physics 42, Nr. 2 (September 1998): 269–76. http://dx.doi.org/10.1016/s0360-3016(98)00232-6.

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Peters, Marion G., H. W. Hann, Paul Martin, E. Jenny Heathcote, P. Buggisch, R. Rubin, M. Bourliere et al. „Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B 1 1The Adefovir Dipivoxil International 461 Study Group includes the following: N. Afdhal (Beth Israel Deaconess Medical Center, Boston, MA); P. Angus (Austin and Repatriation Medical Centre, Melbourne, Australia); Y. Benhamou (Hopital La Pitie Salpetriere, Paris, France); M. Bourliere (Hopital Saint Joseph, Marseille, France); P. Buggisch (Universitaetsklinikum Eppendorf, Department of Medicine, Hamburg, Germany); P. Couzigou (Hopital Haut Leveque, Pessac, France); P. Ducrotte and G. Riachi (Hopital Charles Nicolle, Rouen, France); E. Jenny Heathcote (Toronto Western Hospital, Toronto, Ontario, Canada); H. W. Hann (Jefferson Medical College, Philadelphia, PA); I. Jacobson (New York Presbyterian Hospital, New York, NY); K. Kowdley (University of Washington Hepatology Center, Seattle, WA); P. Marcellin (Hopital Beaujon, Clichy, France); P. Martin (Cedars-Sinai Medical Center, Los Angeles, CA); J. M. Metreau (Centre Hospitalier Universitaire Henri Mondor, Creteil, France); M. G. Peters (University of California, San Francisco, San Francisco, CA); R. Rubin (Piedmont Hospital, Atlanta, GA); S. Sacks (Viridae Clinical Sciences, Inc., Vancouver, Canada); H. Thomas (St. Mary’s Hospital, London, England); C. Trepo (Hopital Hôtel Dieu, Lyon, France); D. Vetter (Hopital Civil, Strasbourg, France); C. L. Brosgart, R. Ebrahimi, J. Fry, C. Gibbs, K. Kleber, J. Rooney, M. Sullivan, P. Vig, C. Westland, M. Wulfsohn, and S. Xiong (Gilead Sciences, Inc., Foster City, CA); D. F. Gray (GlaxoSmithKline, Greenford, Middlesex, England); R. Schilling and V. Ferry (Parexel International, Waltham, MA); and D. Hunt (Covance Laboratories, Princeton, NJ).“ Gastroenterology 126, Nr. 1 (Januar 2004): 91–101. http://dx.doi.org/10.1053/j.gastro.2003.10.051.

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Dissertationen zum Thema "Western Presbyterian Church (Philadelphia, Pa.)"

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Kim, Paul D. „Mentoring preachers, an individualized approach based on the strengths of the mentee“. Theological Research Exchange Network (TREN) Theological Research Exchange Network (TREN) Access this title online, 2007. http://www.tren.com.

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Bücher zum Thema "Western Presbyterian Church (Philadelphia, Pa.)"

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Kocher, Donald Roth. The mother of us all: First Presbyterian Church in Philadelphia, 1698-1998. Philadelphia, Pa. (201 S. 21st St., Philadelphia 19103): The Church, 1998.

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2

Green, Ashbel. Memoirs of the Rev. Joseph Eastburn, stated preacher in the Mariner's Church, Philadelphia: Who departed this life, January 30th, 1828. [S.l: D.R. Eastburn, 1997.

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3

Birkett, Oda Katherine Jacoby. Records of the Tioga Presbyterian Church, January 16, 1859-April 2, 1905. Apollo, PA: Closson Press, 1992.

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4

Heffner, John H. Germantown Market Square Church, Germantown, Philadelphia: Weddings and burials. Topton, [Pa: J.H. Heffner, 1995.

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5

Heffner, John H. Burial records of the Roxborough Presbyterian Churchyard, January 1986. [Topton, Pa: J.H. Heffner, 1997.

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6

Zulker, William Allen. John Wanamaker: King of merchants. Wayne, Pa: Eaglecrest Press, 1993.

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7

Stewart, Reid W. History of Scottish dissenting Presbyterianism in the Philadelphia area, PA: An account of the Associate Presbyterian, Bullion's Associate, Independent Associate, Websterite Associate, Reformed Presbyterian with Synod and General Synod, Gailey's Safety League, Steelite Reformed Presbytery, Associate Reformed, Independent Associate Reformed, and United Presbyterian Church of North America clergy and congregations. Lower Burrell, PA: Point Pleasant, 2004.

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8

Robbins, John W. A companion to "The current justification controversy". Unicoi, Tenn: Trinity Foundation, 2003.

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9

(Foreword), Linda M. Boice, Philip Graham Ryken (Editor), Allen C. Guelzo (Editor), William S. Barker (Editor) und Paul S. Jones (Editor), Hrsg. Tenth Presbyterian Church of Philadelphia: 175 Years of Thinking and Acting Biblically. P & R Publishing, 2004.

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10

The Current Justification Controversy - Westminster Theological Seminary (Trinity Paper No. 63). The Trinity Foundation, 2003.

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