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Auswahl der wissenschaftlichen Literatur zum Thema „Vestibular defect“
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Zeitschriftenartikel zum Thema "Vestibular defect"
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Samuel, Orit, Avi Shupak, Ayelet Eran und Dror Tal. „Vestibular Derangement and Motion Intolerance in VATER Association“. Case Reports in Otolaryngology 2017 (2017): 1–2. http://dx.doi.org/10.1155/2017/4507323.
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VATER association is a nonrandom occurrence of congenital malformations: vertebral defects, anal atresia, tracheoesophageal fistula, renal defects, and radial bone anomalies. We report the case of a 19-year-old man with a childhood diagnosis of VATER association, who presented to the motion sickness clinic with severe seasickness. We discuss the clinical and laboratory diagnosis of vestibular pathophysiology, which was confirmed by MRI of lateral semicircular canal and vestibule dysplasia. We suggest the possibility of vestibular involvement as part of the developmental field defect associated with VATER syndrome, which hitherto has rarely been reported.
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Loomba, Rohit S., Justin T. Tretter, Timothy J. Mohun, Robert H. Anderson, Scott Kramer und Diane E. Spicer. „Identification and Morphogenesis of Vestibular Atrial Septal Defects“. Journal of Cardiovascular Development and Disease 7, Nr. 3 (10.09.2020): 35. http://dx.doi.org/10.3390/jcdd7030035.
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Background: The vestibular atrial septal defect is an interatrial communication located in the antero-inferior portion of the atrial septum. Reflecting either inadequate muscularization of the vestibular spine and mesenchymal cap during development, or excessive apoptosis within the developing antero-inferior septal component, the vestibular defect represents an infrequently recognized true deficiency of the atrial septum. We reviewed necropsy specimens from three separate archives to establish the frequency of such vestibular defects and their associated cardiac findings, providing additional analysis from developing mouse hearts to illustrate their potential morphogenesis. Materials and methods: We analyzed the hearts in the Farouk S. Idriss Cardiac Registry at Ann and Robert H. Lurie Children’s Hospital in Chicago, IL, the Van Mierop Archive at the University of Florida in Gainesville, Florida, and the archive at Johns Hopkins All Children’s Heart Institute in St. Petersburg, Florida, identifying all those exhibiting a vestibular atrial septal defect, along with the associated intracardiac malformations. We then assessed potential mechanisms for the existence of such defects, based on the assessment of 450 datasets of developing mouse hearts prepared using the technique of episcopic microscopy. Results: We analyzed a total of 2100 specimens. Of these, 68 (3%) were found to have a vestibular atrial septal defect. Comparable defects were identified in 10 developing mouse embryos sacrificed at embryonic data 15.5, by which stage the antero-inferior component of the atrial septum is usually normally formed. Conclusion: The vestibular defect is a true septal defect located in the muscular antero-inferior rim of the oval fossa. Our retrospective review of autopsied hearts suggests that the defect may be more common than previously thought. Increased awareness of the location of the defect should optimize its future clinical identification. We suggest that the defect exists because of failure, during embryonic development, of union of the components that bind the leading edge of the primary atrial septum to the atrioventricular junctions, either because of inadequate muscularisation or excessive apoptosis.
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Fukuda, Toyoki, Ichiro Kashima und Shigeki Yoshiba. „Surgical treatment of an unusual atrial septal defect: the vestibular defect“. Cardiology in the Young 14, Nr. 2 (April 2004): 212–14. http://dx.doi.org/10.1017/s1047951104002197.
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A 14-year-old female patient underwent surgical treatment of multiple atrial septal defects associated with unroofed coronary sinus and pulmonary valvar stenosis. One of the defects was that of the superior oval fossa and the other a large ellipsoidal defect positioned inferior to the inferior rim of the oval fossa. The patient underwent primary closure of the defects with a favorable result. To the best of our knowledge, this is the first surgical experience of an unusual atrial septal defect or the vestibular defect.
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Hadrys, T., T. Braun, S. Rinkwitz-Brandt, H. H. Arnold und E. Bober. „Nkx5-1 controls semicircular canal formation in the mouse inner ear“. Development 125, Nr. 1 (01.01.1998): 33–39. http://dx.doi.org/10.1242/dev.125.1.33.
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The inner ear develops from the otic vesicle, a one-cell-thick epithelium, which eventually transforms into highly complex structures including the sensory organs for balance (vestibulum) and hearing (cochlea). Several mouse inner ear mutations with hearing and balance defects have been described but for most the underlying genes have not been identified, for example, the genes controlling the development of the vestibular organs. Here, we report the inactivation of the homeobox gene, Nkx5-1, by homologous recombination in mice. This gene is expressed in vestibular structures throughout inner ear development. Mice carrying the Nkx5-1 null mutation exhibit behavioural abnormalities that resemble the typical hyperactivity and circling movements of the shaker/waltzer type mutants. The balance defect correlates with severe malformations of the vestibular organ in Nkx5-1(−/−) mutants, which fail to develop the semicircular canals. Nkx5-1 is the first ear-specific molecule identified to play a crucial role in the formation of the mammalian vestibular system.
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Pardo-Zamora, Guillermo, José Antonio Moreno-Rodríguez und Antonio J. Ortiz-Ruíz. „Non-Incised Papilla Surgical Approach and Leukocyte Platelet-Rich Fibrin in Periodontal Reconstruction of Deep Intrabony Defects: A Case Series“. International Journal of Environmental Research and Public Health 18, Nr. 5 (03.03.2021): 2465. http://dx.doi.org/10.3390/ijerph18052465.
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We present the preliminary results of the treatment of teeth with a deep, non-contained periodontal residual defect, vestibular bone dehiscence, and soft tissue recession, by combining an apical non-incised papilla surgical approach (NIPSA) to the defect and leukocyte platelet-rich fibrin (L-PRF) in the vestibular aspect. Four patients (upper left first premolar, upper left central incisor, upper right central incisor and upper right lateral incisor) have been treated. At one year of follow up, all cases showed a considerable reduction in the periodontal pocket depth, a gain in clinical attachment and no bleeding on probing, as well as an improvement in the marginal soft tissue minimizing soft tissue contraction (recession and/or loss of papilla) and improving soft tissue architecture. NIPSA plus L-PRF seem to improve clinical outcomes in deep non-contained intrabony defects associated with soft tissue recession.
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Tsukada, Keita, Hisakuni Fukuoka und Shin-ichi Usami. „Vestibular Functions of Hereditary Hearing Loss Patients with GJB2 Mutations“. Audiology and Neurotology 20, Nr. 3 (2015): 147–52. http://dx.doi.org/10.1159/000368292.
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Objectives: Mutations in the GJB2 gene have been of particular interest as it is the most common causative gene for congenital deafness in all populations. Detailed audiological features, including genotype-phenotype correlations, have been well documented. However, in spite of abundant gene as well as protein expression in the vestibular end organs, neither vestibular symptoms nor vestibular functions have yet been elucidated. In the present study, vestibular functions were evaluated in patients diagnosed with GJB2-related deafness. Subjects and Methods: Vestibular functions were evaluated by caloric test and cervical vestibular evoked myogenic potential (cVEMP) testing in 24 patients with biallelic GJB2 mutations. Results and Discussion: Twenty-one of 23 patients (91.3%) had normal caloric responses and significantly lower cVEMP amplitudes than the control subjects. In the patients who were able to undergo vestibular testing, the mostly normal reactions to caloric testing indicated that the lateral semicircular canal was intact. However, the majority of GJB2 patients showed low cVEMP reactions, indicating a saccular defect.
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Lim, H. W., H. J. Park, J. H. Jung und J. W. Chung. „Surgical treatment of posterior semicircular canal dehiscence syndrome caused by jugular diverticulum“. Journal of Laryngology & Otology 126, Nr. 9 (17.07.2012): 928–31. http://dx.doi.org/10.1017/s0022215112001570.
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AbstractObjective:We report a rare case of posterior semicircular canal dehiscence caused by a jugular diverticulum, and we describe its surgical treatment using a dehiscence resurfacing manoeuvre.Method:The clinical findings, surgical procedure and outcomes are presented.Results:A 66-year-old man presented with disequilibrium, sound-induced vertigo, a reduced ocular vestibular evoked myogenic potential threshold, and pressure-induced vertical and torsional nystagmus. Computed tomography revealed a right posterior semicircular canal dehiscence caused by a diverticulum of the jugular bulb. The defect in the posterior semicircular canal was localised and resurfaced with bone paté, temporalis muscle fascia and conchal cartilage, under direct visualisation. Post-operatively, the patient's symptoms disappeared and his ocular vestibular evoked myogenic potential threshold normalised.Conclusion:This case illustrates that posterior semicircular canal dehiscence can be surgically managed by resurfacing the defect site via a transmastoid approach.
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Bath, Andrew P., Rory M. Walsh und Manohar L. Bance. „Presumed reduction of vestibular function in unilateral Menière's disease with aminoglycoside eardrops“. Journal of Laryngology & Otology 113, Nr. 10 (Oktober 1999): 916–18. http://dx.doi.org/10.1017/s002221510014558x.
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AbstractWe report the first case in the world literature of deliberate ablation of vestibular function in unilateral Meniere's disease with aminoglycoside eardrops (Garasone).These findings give conclusive proof that Garasone eardrops, and by implication, all topical aminoglycoside ear drops can be vestibulotoxic in the presence of a tympanic membrane defect. The lower concentration of gentamicin in Garasone, in comparison to the standard intratympanic preparations for chemical ablation of vestibular function, may also offer a reduction in the potential risk of cochleotoxocity.
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Saida, Hiroyuki, Shunsuke Fukuba, Takahiko Shiba, Keiji Komatsu, Takanori Iwata und Hiroshi Nitta. „Two-stage approach for class II mandibular furcation defect with insufficient keratinized mucosa: a case report with 3 years’ follow-up“. Journal of International Medical Research 49, Nr. 9 (September 2021): 030006052110445. http://dx.doi.org/10.1177/03000605211044595.
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Periodontal regenerative treatment is useful for intrabony defects and furcation involvement, but is difficult when there is insufficient keratinized mucosa to cover and maintain the regenerative material, particularly in the mandibular molar region. We report the case of a 27-year-old woman who underwent a two-stage surgical approach for a class II furcation defect with gingival recession and insufficient keratinized mucosal width (KMW) and vestibular depth at the mandibular left first molar. We first improved the KMW and keratinized mucosal thickness using an epithelial embossed connective tissue graft with enamel matrix derivative, and then focused on periodontal regeneration at the furcation defect using an enamel matrix derivative and a bovine-derived xenograft. Probing depth reduction, clinical attachment gain, horizontal probing depth reduction, KMW gain, and gingival recession reduction were observed 3 years postoperatively. This case report suggests that this novel staged approach may be effective for treating furcation defects with insufficient keratinized mucosa, thus providing useful insights into periodontal regeneration therapy.
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Bi, Wenya Linda, Ryan Brewster, Dennis Poe, David Vernick, Daniel J. Lee, C. Eduardo Corrales und Ian F. Dunn. „Superior semicircular canal dehiscence syndrome“. Journal of Neurosurgery 127, Nr. 6 (Dezember 2017): 1268–76. http://dx.doi.org/10.3171/2016.9.jns16503.
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Superior semicircular canal dehiscence (SSCD) syndrome is an increasingly recognized cause of vestibular and/or auditory symptoms in both adults and children. These symptoms are believed to result from the presence of a pathological mobile “third window” into the labyrinth due to deficiency in the osseous shell, leading to inadvertent hydroacoustic transmissions through the cochlea and labyrinth. The most common bony defect of the superior canal is found over the arcuate eminence, with rare cases involving the posteromedial limb of the superior canal associated with the superior petrosal sinus. Operative intervention is indicated for intractable or debilitating symptoms that persist despite conservative management and vestibular sedation. Surgical repair can be accomplished by reconstruction or plugging of the bony defect or reinforcement of the round window through a variety of operative approaches. The authors review the etiology, pathophysiology, presentation, diagnosis, surgical options, and outcomes in the treatment of this entity, with a focus on potential pitfalls that may be encountered during clinical management.
Dissertationen zum Thema "Vestibular defect"
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Calvet, Charlotte. „Synaptopathies auditives et vestibulaires : de la physiologie moléculaire à la thérapie génique“. Electronic Thesis or Diss., Sorbonne université, 2020. http://www.theses.fr/2020SORUS195.
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La surdité est le déficit sensoriel le plus fréquent chez l'Homme et touche plus de 466 millions de personnes dans le monde. En France, un enfant sur 1000 naît avec une surdité sévère ou profonde. La surdité peut être associée à des troubles de l'équilibre. Face à l'absence de traitement curatif, la thérapie génique apparaît comme une alternative prometteuse pour le traitement des surdités et des troubles vestibulaires d’origine génétique. Les études de thérapie génique chez les modèles murins reposent notamment sur l’utilisation des virus adéno-associés (AAV) comme vecteurs de gènes. Dans le cadre de cette thèse, nous avons utilisé les AAV pour la thérapie génique des surdités et troubles vestibulaires et pour l’étude physiologique de la fonction des gènes. Plus précisément, nous nous sommes intéressés à trois protéines dont le dysfonctionnement entraine une atteinte neurosensorielle : l’OTOFERLINE, la SNAP-25 et SANS. Les résultats obtenus chez la souris montrent qu’il est possible de restaurer la structure et la fonction des cellules ciliées sensorielles de l'oreille interne, au niveau synaptique et stéréociliaire grâce au transfert in vivo de gènes thérapeutiques contenus dans un AAV. L’utilisation d’AAV exprimant Snap-25 a également permis de mettre en évidence le rôle de cette protéine dans la survie et l’exocytose de la cellule ciliée interne. Ainsi, nous avons restauré l'audition et l’équilibre dans différents modèles de synaptopathies auditives et vestibulaires. Ce projet ouvre la voie à de nouvelles approches thérapeutiques des formes génétiques de surdités et troubles vestibulaires chez l’HommeHearing loss is the most common sensory deficit, affecting more than 466 million people worldwide. In France, one in 1,000 children is born with severe to profound deafness, Hearing loss is often associated with balance impairments. Currently, there is no curative treatment available, however the possibility of gene therapy is a promising alternative treatment for deafness and vestibular disorders of genetic origin. Gene therapy studies in mouse models particularly rely on the use of adeno-associated viruses (AAVs) for gene delivery. In this thesis, we used AAVs for both gene therapy of hearing loss and vestibular disorders and to study physiological gene function. Specifically, we looked at three proteins whose dysfunction leads to neurosensory impairment: OTOFERLINE, SNAP-25 and SANS.Our results obtained in mice show that it is possible to restore the structure and function of inner ear sensory hair cells, at the synaptic and stereociliary levels, by in vivo transfer of therapeutic genes contained in an AAV. The use of AAV expressing Snap-25 demonstrated the role of this protein in both the survival and exocytosis of inner hair cells. Thus, we restored hearing and balance in different models of auditory and vestibular synaptopathies. This project opens up new perspectives for the treatment of genetic forms of deafness and vestibular disorders in humans
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Segnini, Bruno [UNESP]. „Preservação da arquitetura tecidual de alvéolos com defeito ósseo vestibular: análise clínica e tomográfica de uma série de casos“. Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/148024.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
O objetivo deste estudo foi avaliar em humanos a preservação do contorno do tecido ósseo e gengival após a exodontia e enxertia com matriz de colágeno suíno (mucograft), membrana de colágeno (suíno) e osso bovino desproteinizado associado a colágeno suíno (collagen). Foram selecionados 6 pacientes provenientes da clínica da Faculdade de Odontologia de Araraquara que possuíam um pré-molar, canino ou incisivo superior indicado para exodontia e que apresentaram defeito ósseo vestibular. Todos os alvéolos receberam enxerto com matriz de colágeno suíno, membrana de colágeno e osso bovino desproteinizado acrescido de colágeno. Os dados clínicos e fotográficos foram coletados ao início do estudo, aos 7, 15, 30 e 120 dias após o procedimento cirúrgico. Foram realizados exames clínicos referentes ao aspecto da área operada, altura e espessura de gengiva queratinizada, nível gengival, biotipo gengival, assim como mensurações digitais da altura de margem gengival, e das papilas mesial e distal. Para verificação da estrutura óssea e gengival inicial e após os enxertos foram realizados exames tomográficos no início do estudo e após quatro meses do procedimento cirúrgico inicial. Os resultados mostraram que a técnica promoveu um ganho de osso vestibular, dessa forma foi concluído que a manutenção do alvéolo com a associação da matriz de colágeno suíno, membrana de colágeno e osso bovino desproteinizado promoveu boa estabilidade do volume do alvéolo com aumento do osso associado a parede vestibular, entretanto, serão necessários estudos clínicos controlados e randomizados para entender o real benefício dessa técnica em comparação a outras técnicas de manutenção do volume alveolar anteriormente propostas.
The purpose of this case-series trial was to evaluate the maintenance of the soft and hard tissues margins after tooth-extraction and grafting with a combination of the following materials: demineralized bovine bone associated with pig-collagen; pig-collagen membrane; and pig-collagen matrix. For this study six patients were selected among those who attended to the Araraquara Dental School Clinics throughout the last six months of 2015; they all had a pre-molar, canine or incisive tooth with buccal bone loss, which needed to be extracted. All the sockets were grafted with a combination of the same biomaterials: demineralized bovine bone associated with pig-collagen; pig-collagen membrane; and pig-collagen matrix. Clinical and photographic data were collected at base line, 7, 15, 30 and 120 days after surgery. Clinical assessments of the surgical site included keratinized mucosa height and thickness; gingival level; gingival biotype; as well as digital measurements of the gingival margin and both proximal papillae heights. In order to assess changes at the gingival and bone structures, cone-beam tomographic examinations were carried out at baseline and 4 months after surgery. Results showed buccal bone gain as this reconstructive technique was employed, so it was concluded that the treatment with demineralized bovine bone associated with pig-collagen, combined with pig-collagen membrane and pig-collagen matrix promoted satisfactory socket volume maintenance with associated buccal wall bone gain. Further randomized-clinical-controlled studies, however, need to be carried out in order to investigate the actual advantages of this approach when compared to other socket-volume-maintenance techniques previously described in the literature.
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Segnini, Bruno. „Preservação da arquitetura tecidual de alvéolos com defeito ósseo vestibular : análise clínica e tomográfica de uma série de casos /“. Araraquara, 2016. http://hdl.handle.net/11449/148024.
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Orientador: Elcio Junior MarcantonioCo-orientador: Fausto Frizzera Borges Filho
Resumo: O objetivo deste estudo foi avaliar em humanos a preservação do contorno do tecido ósseo e gengival após a exodontia e enxertia com matriz de colágeno suíno (mucograft), membrana de colágeno (suíno) e osso bovino desproteinizado associado a colágeno suíno (collagen). Foram selecionados 6 pacientes provenientes da clínica da Faculdade de Odontologia de Araraquara que possuíam um pré-molar, canino ou incisivo superior indicado para exodontia e que apresentaram defeito ósseo vestibular. Todos os alvéolos receberam enxerto com matriz de colágeno suíno, membrana de colágeno e osso bovino desproteinizado acrescido de colágeno. Os dados clínicos e fotográficos foram coletados ao início do estudo, aos 7, 15, 30 e 120 dias após o procedimento cirúrgico. Foram realizados exames clínicos referentes ao aspecto da área operada, altura e espessura de gengiva queratinizada, nível gengival, biotipo gengival, assim como mensurações digitais da altura de margem gengival, e das papilas mesial e distal. Para verificação da estrutura óssea e gengival inicial e após os enxertos foram realizados exames tomográficos no início do estudo e após quatro meses do procedimento cirúrgico inicial. Os resultados mostraram que a técnica promoveu um ganho de osso vestibular, dessa forma foi concluído que a manutenção do alvéolo com a associação da matriz de colágeno suíno, membrana de colágeno e osso bovino desproteinizado promoveu boa estabilidade do volume do alvéolo com aumento do osso associado a parede ve... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: To evaluate in vitro the primary stability of short and conventional sized implants with different platform types and bone densities. Material and methods: 120 implants were installed in polyurethane blocks wich simulate different bone densities (bone type I and IV). The implants were divided into 10 groups according to the type of prosthetic connections (external hexagon, and morse taper) and size of the implants (conventional, short, and short-modified). Insertion torque and resonance frequency analyzes were performed. The Kruskal- Wallis test complemented by Dunn test and the Mann-Whitney test were used for statistical analysis and were applied at the confidence level of 95 % (p < 0.05). Results: The implants inserted in the blocks with density type IV had lower insertion torque than the implants placed in the blocks with density type I. Implants with conventional external hexagon had lower insertion torque than the short, and short- modified implants with cone morse taper. Additionally, when the implants with conventional external hexagon and modified morse taper were used, the resonance frequency was higher in the block with bone density I. It was also showed that the short implants with morse taper had higher resonance frequency values than the short- modified implants with morse taper implants when the implants were placed in the blocks with bone density type IV. Conclusion: Short implants have primary stability equivalent to conventional implants regardless of platform type and density of the surgical site. Activities to be undertaken it still runs the analize of short implants with 6mm in length (IC6HE groups, IC6CM, ICM6HE and ICM6CM). It will increase...(Complete abstract electronic access below)
Mestre
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Alvira, González Joaquín. „Utilización de células madre adiposas en procesos de regeneración ósea guiada en defectos de tamaño crítico de la cortical vestibular“. Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/404301.
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La colocación de implantes se ve limitada en ocasiones por defectos del reborde alveolar debidos principalmente a extracciones traumáticas, procesos infecciosos de los dientes o bien a la reabsorción ósea que tiene lugar tras su extracción. La asociación de los procedimientos de regeneración ósea guiada con técnicas de ingeniería tisular que utilizan células madre en combinación con proteínas que contienen moléculas bioactivas, tiene como objetivo regenerar los defectos óseos con un resultado similar al conseguido por los injertos de hueso autólogo.
OBJETIVOS: Determinar el porcentaje de tejido óseo neoformado en defectos críticos de la cortical vestibular mandibular regenerados con un material fosfocálcico (β Fosfato tricálcico, β-TCP) recubierto de fibronectina (Fn) y células madre autólogas de origen adiposo (ADSCs) (β-TCP-Fn-ADSCs) de forma previa o simultánea a la colocación de implantes dentales y compararlo con el obtenido usando un material fosfocálcico sólo (β-TCP) o bien recubierto con fibronectina (β-TCP-Fn), a los tres meses de cicatrización. Asimismo se determinó el porcentaje de hueso en contacto con la superficie de un implante dental en defectos críticos de la cortical vestibular regenerados con los mismos sustitutos óseos a los tres meses de cicatrización.
MATERIAL Y MÉTODO: Se efectuaron dos estudios experimentales en 18 perros Beagle, que fueron aprobados por el Comitè Ètic D ́ Experimentació Animal (CEEA 227-109) de la Universitat de Barcelona. Los procedimientos se dividieron en dos fases. En un primer acto quirúrgico se realizaron las exodoncias de ambas hemimandíbulas así como la obtención de la grasa abdominal a partir de la cual se extraerían las células madre adiposas. En la segunda fase quirúrgica se llevó a cabo la creación de cuatro defectos críticos de tipo dehiscencia en cada hemimandíbula que serían regenerados de forma aleatoria con un material fosfocálcico con diferentes tipos de recubrimiento (β-TCP-Fn-ADSCs, β-TCP-Fn, β-TCP), dejando un defecto vació a modo de control. En una hemimandíbula de cada perro se colocó un implante dental en cada defecto de forma simultánea a los procedimientos regenerativos. Los perros se dividieron en tres grupos de estudio que se sacrificaron a 1, 2 o 3 meses del postoperatorio (T1, T2 y T3). Se comprobó la normalidad de las distribuciones mediante la prueba de Kolmogorov-Smirnov. Se calcularon las medias y las desviaciones estándar de los parámetros analizados en el estudio histomorfométrico de las muestras. Las diferencias de las variables histomorfométricas entre el grupo control y los tres grupos de estudio (β-TCP, β-TCP-Fn y β-TCP-Fn-ADSC) en T1, T2 y T3 fueron evaluados con el análisis de la varianza (ANOVA) y las diferencias entre los datos en T1, T2 y T3 con la prueba t-Student para muestras apareadas. Se estableció un valor de significación estadística de p< 0,05.
Resultados: El porcentaje de tejido óseo neoformado en defectos críticos de la cortical vestibular tratado con β-TCP-Fn-ADSCs no fue superior al registrado con β-TCP sólo o recubierto con fibronectina (β-TCP-Fn). Asimismo, ninguno de los tres grupos estudio se mostraron superiores frente a los defectos control en los tres tiempos analizados. Los implantes regenerados con β-TCP-Fn-ADSCs no sólo no mejoró los índices de BIC a lo largo de los tres meses de cicatrización frente al resto de defectos sino que incluso registró valores estadísticamente inferiores a los defectos tratados con β-TCP-Fn o al defecto control a los dos meses de cicatrización (p=0,041 y p=0,012). Sin embargo, la utilización de células madre adiposas y fibronectina recubriendo un material fosfocálcico mantuvo el espacio regenerado de forma más eficiente a los tres meses de cicatrización.
Conclusiones: La combinación de células madre adiposas con fibronectina como recubrimiento de un biomaterial fosfocálcico en procedimientos regenerativos de defectos de tipo dehiscencia no parece incrementar el porcentaje de tejido óseo neoformado así como de aposición ósea en la superficie de implantes. No obstante, mantiene el espacio regenerado de forma más eficiente a los tres meses de cicatrización con respecto al resto de grupos.The aim of both experimental studies was to assess bone regeneration potential as well as percentage of BIC (bone implant contact) in three-wall critical size defects of vestibular cortical bone after tooth extraction and implant placement, using a ceramic biomaterial (β-tricalcium phosphate β-TCP) alone or coated with fibronectin (β-TCP-Fn), or the combination of fibronectin and ADSCs (β-TCP -Fn-ADSCs) as compared with a control defect (without biomaterial filling) after three months of healing. MATERIAL AND METHOD: Both studies were carried out on 18 Beagle dogs. They were approved by the Committee of Animal Experimentation (CEEA 227-109) of the University of Barcelona. Four critical dehiscence defects were created in both hemiarches that were randomly regenerated with a different phosphocalic material (β-TCP-Fn-ADSCs, β-TCP-Fn, β-TCP). One defect was left empty as a control. A dental implant was placed simultaneously to the regenerative procedures in each defect of one hemiarch. The animals were divided into three groups according to the time of euthanasia (1, 2, or 3 months of healing). The differences in the histomorphometric variables between the control group and the three study groups (β-TCP, β-TCP-Fn and β-TCP-Fn-ADSC) at T1, T2 and T3 were evaluated with the analysis of variance (ANOVA) and the differences between data at T1, T2 and T3 with the Student's t-test for paired samples. RESULTS: The percentage of neoformed bone as well as BIC in critical size defects of vestibular cortical bone treated with β-TCP-Fn-ADSCs was not statistically superior than that registered with β-TCP alone or coated with fibronectin (β-TCP-Fn). Likewise, none of the three study groups were superior to the control defects in the three evaluated times. However, the use of adipose stem cells and fibronectin coating a phosphocalcium material maintained the regenerated space more efficiently after three months of healing. CONCLUSIONS: The combination of adipose stem cells with fibronectin as a coating of a phosphocalcium biomaterial in regenerative procedures of dehiscence type defects does not seem to increase the percentage of neoformed bone tissue as well as bone apposition on the implant surface. However, it maintains the regenerated space more efficiently after three months of healing compared to the other groups.
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Gil, López-Areal Alfonso. „Three-dimensional volumetric analysis of root coverage and gingival volume gain of multiple recession-type defects treated by Vestibular Incision Subperiosteal Tunnel Access (VISTA)“. Doctoral thesis, Universitat Internacional de Catalunya, 2019. http://hdl.handle.net/10803/668029.
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Objective: To examine the outcome of root coverage and gingival volume changes, following the treatment of multiple recession-type defects treated with Vestibular Incision Subperiosteal Tunnel Access (VISTA) in combination with various graft materials.
Materials and Methods: Pre-therapy and post-therapy study models of 21 patients (154 teeth) with multiple gingival recession defects, treated with Vestibular Incision Subperiosteal Tunnel Access (VISTA), were optically scanned. Three-dimensional analysis of superimposed preoperative and postoperative images (more than 12-month follow-up) was performed. Linear and surface root coverage were calculated together with linear gingival thickness and volumetric gain. These outcomes were correlated to various clinical and/or anatomical parameters. A stringent nonparametric regression analysis was run, adjusting for the correlation among multiple observations on the same patient.
Results: The mean percentages of linear root coverage were 96.2 ± 13.1% and 84.3 ± 14.4% for Miller Class I/II (Cairo RT1) and Class III (Cairo RT2) recessions, respectively. The mean percentages of root surface area coverage were 92.1 ± 12.0% and 78.6 ± 15.7% for Miller Class I/II (RT1) and III (RT2) defects, respectively. Linear gingival thickness gain of approximately 1 mm and volumetric gain of 5.47mm3 was achieved. Root prominence, initial recession width and posterior tooth type were negatively correlated with linear and root surface area coverage. A strong negative correlation was found between linear thickness gain and root prominence. The thickness gained achieved was not significantly different with various graft materials.
Conclusion: Three-dimensional analysis provides a useful method for evaluating the outcome of periodontal plastic surgery. The results of the present study showed root coverage, gingival thickness and volumetric gain achieved with VISTA in combination with different graft materials. Certain site-specific factors, in particular root prominence, exerted an influence of the outcomes of root coverage and gingival volume gain.
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Wilkes, Margaret. „Clinical and morphological investigations into inner ear disease in the dog with special reference to deafness and vestibular deficit in the Doberman“. Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385502.
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Santos, Andreza Souza. „Inclus?o de estudantes com defici?ncia nas institu???es de ensino superior da cidade do Natal/RN:an?lise das condi??es oferecidas no processo seletivo vestibular“. Universidade Federal do Rio Grande do Norte, 2012. http://repositorio.ufrn.br:8080/jspui/handle/123456789/14561.
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Previous issue date: 2012-07-05The number of disabled students, who have entered the university, in Brazil, since the beginning of this century, is undergoing a speed growth. It is a change that follows a global trend that spreads an inclusive education policy and that has had a profound impact on Brazil, with import results in field researches. This subject has been highlighted due to the significant amount of disabled students enrolled in college institutions (IES), although it is still modest the number of studies about it, especially in what matters the assistance given to the candidates to a university entrance examination. The aim of this paper is to investigate how effectively Natal s IES apply the rules established in Brazilian law concerning disabled students, especially MEC/GM Circular Warning n. 277/96, in what respects the conditions given to disabled students preparing to enter a college. The investigation followed a qualitative methodological approach with support on an exploratory study. The data recollection employed questionnaire, semi-structured interview and documental analyses, and the data have been organized and assessed following Minayo s (1996) stages. What concerns the results, it was observed that none of the ten colleges inquired confirmed to possess places exclusively to disabled candidates; six of them, however, offer Special Examining Board in the selection process of disabled candidates. Among eighteen college bills, only two of them offered specific information related to services and resources offered by IES to the candidates who ask for especial assistance concerning examination. During the interviews, four managers avowed the preoccupation in offering an equal selection process, but two of them proved not dominate the subject. In conclusion, the investigated institutions managers do not still seem to respect the rule that guarantees to disabled candidates equal conditions during all the process of the university entrance examination. With this work, we hope do help changing this focus and contribute to new studies on disabled persons studying for a degree
O n?mero de pessoas com defici?ncia que tem ingressado no Ensino Superior, no Brasil, aumentou significativamente no in?cio do s?culo XXI. Essa mudan?a resulta das discuss?es em torno da implanta??o da pol?tica de educa??o inclusiva no contexto internacional, inclusive em nosso pa?s, refletindo no campo da pesquisa. A tem?tica come?a a se destacar impulsionada pelo aumento do n?mero de matr?culas de estudantes com defici?ncia nas Institui??es de Ensino Superior (IES). No entanto, a quantidade de estudos ainda ? escassa, principalmente no que se refere ao atendimento oferecido pelos candidatos com defici?ncia no vestibular das IES. Nesse sentido, o objetivo deste trabalho foi investigar em que medida as IES da cidade do Natal-RN est?o seguindo as recomenda??es contidas na legisla??o brasileira, especificamente a do Aviso Circular N? 277/96-MEC/GM, no que tange ?s condi??es oferecidas aos estudantes com defici?ncia para o processo seletivo vestibular. A investiga??o caracteriza-se por uma abordagem metodol?gica qualitativa do tipo Estudo Explorat?rio. A constru??o dos dados se deu atrav?s da aplica??o de question?rio, entrevista semiestruturada e an?lise documental, sendo os dados coletados organizados e interpretados segundo as etapas indicadas por Minayo (1998). Em rela??o aos resultados, constatou-se que das dez institui??es de ensino superior que devolveram o question?rio, nenhuma delas possu?a reserva de vagas para candidatos com defici?ncia e, apenas seis afirmaram oferecer Banca Especial no processo seletivo para ingresso na gradua??o. Dos dezoito editais analisados, somente dois apresentavam informa??es claras aos candidatos sobre os servi?os e recursos oferecidos pela IES a quem solicita atendimento especial para realiza??o das provas. Dos quatro gestores que participaram da entrevista semiestruturada, constatou-se que todos revelaram preocupa??o em oferecer um processo seletivo igualit?rio, mas parte deles n?o demonstrou possuir muito conhecimento acerca da legisla??o espec?fica. Conclui-se que h? necessidade de os gestores das institui??es investigadas cumprirem com a legisla??o em vigor assegurando aos candidatos com defici?ncia o direito de concorrer no processo seletivo vestibular, em igualdade de oportunidades, em todas as etapas, desde a inscri??o at? a corre??o final das provas. Espera-se, com esta investiga??o, tamb?m contribuir para o avan?o das discuss?es e novos estudos em torno do acesso das pessoas com defici?ncia ao ensino superior
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Blini, Elvio A. „Biases in Visuo-Spatial Attention: from Assessment to Experimental Induction“. Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424480.
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In this work I present several studies, which might appear rather heterogeneous for both experimental questions and methodological approaches, and yet are linked by a common leitmotiv: spatial attention. I will address issues related to the assessment of attentional asymmetries, in the healthy individual as in patients with neurological disorders, their role in various aspects of human cognition, and their neural underpinning, driven by the deep belief that spatial attention plays an important role in various mental processes that are not necessarily confined to perception.
What follows is organized into two distinct sections. In the first I will focus on the evaluation of visuospatial asymmetries, starting from the description of a new paradigm particularly suitable for this purpose. In the first chapter I will describe the effects of multitasking in a spatial monitoring test; the main result shows a striking decreasing in detection performance as a function of the introduced memory load. In the second chapter I will apply the same paradigm to a clinical population characterized by a brain lesion affecting the left hemisphere. Despite a standard neuropsychological battery failed to highlight any lateralized attentional deficit, I will show that exploiting concurrent demands might lead to enhanced sensitivity of diagnostic tests and consequently positive effects on patients’ diagnostic and therapeutic management. Finally, in the third chapter I will suggest, in light of preliminary data, that attentional asymmetries also occur along the sagittal axis; I will argue, in particular, that more attentional resources appear to be allocated around peripersonal space, the resulting benefits extending to various tasks (i.e., discrimination tasks).
Then, in the second section, I will follow a complementary approach: I will seek to induce attentional shifts in order to evaluate their role in different cognitive tasks. In the fourth and fifth chapters this will be pursued exploiting sensory stimulations: visual optokinetic stimulation and galvanic vestibular stimulation, respectively. In the fourth chapter I will show that spatial attention is highly involved in numerical cognition, this relationship being bidirectional. Specifically, I will show that optokinetic stimulation modulates the occurrence of procedural errors during mental arithmetics, and that calculation itself affects oculomotor behaviour in turn. In the fifth chapter I will examine the effects of galvanic vestibular stimulation, a particularly promising technique for the rehabilitation of lateralized attention disorders, on spatial representations. I will discuss critically a recent account for unilateral spatial neglect, suggesting that vestibular stimulations or disorders might indeed affect the metric representation of space, but not necessarily resulting in spatial unawareness. Finally, in the sixth chapter I will describe an attentional capture phenomenon by intrinsically rewarding distracters. I will seek, in particular, to predict the degree of attentional capture from resting-state functional magnetic resonance imaging data and the related brain connectivity pattern; I will report preliminary data focused on the importance of the cingulate-opercular network, and discuss the results through a parallel with clinical populations characterized by behavioural addictions.In questo lavoro presenterò una serie di ricerche che possono sembrare piuttosto eterogenee per quesiti sperimentali e approcci metodologici, ma sono tuttavia legate da un filo conduttore comune: i costrutti di ragionamento e attenzione spaziale. Affronterò in particolare aspetti legati alla valutazione delle asimmetrie attenzionali, nell'individuo sano come nel paziente con disturbi neurologici, il loro ruolo in vari aspetti della cognizione umana, e i loro substrati neurali, guidato dalla convinzione che l’attenzione spaziale giochi un ruolo importante in svariati processi mentali non necessariamente limitati alla percezione. Quanto segue è stato dunque organizzato in due sezioni distinte. Nella prima mi soffermerò sulla valutazione delle asimmetrie visuospaziali, iniziando dalla descrizione di un nuovo paradigma particolarmente adatto a questo scopo. Nel primo capitolo descriverò gli effetti del doppio compito e del carico attenzionale su un test di monitoraggio spaziale; il risultato principale mostra un netto peggioramento nella prestazione al compito di detezione spaziale in funzione del carico di memoria introdotto. Nel secondo capitolo applicherò lo stesso paradigma ad una popolazione clinica contraddistinta da lesione cerebrale dell’emisfero sinistro. Nonostante una valutazione neuropsicologica standard non evidenziasse alcun deficit lateralizzato dell’attenzione, mostrerò che sfruttare un compito accessorio può portare ad una spiccata maggiore sensibilità dei test diagnostici, con evidenti ricadute benefiche sull'iter clinico e terapeutico dei pazienti. Infine, nel terzo capitolo suggerirò, tramite dati preliminari, che asimmetrie attenzionali possono essere individuate, nell'individuo sano, anche lungo l’asse sagittale; argomenterò, in particolare, che attorno allo spazio peripersonale sembrano essere generalmente concentrate più risorse attentive, e che i benefici conseguenti si estendono a compiti di varia natura (ad esempio compiti di discriminazione). Passerò dunque alla seconda sezione, in cui, seguendo una logica inversa, indurrò degli spostamenti nel focus attentivo in modo da valutarne il ruolo in compiti di varia natura. Nei capitoli quarto e quinto sfrutterò delle stimolazioni sensoriali: la stimolazione visiva optocinetica e la stimolazione galvanico vestibolare, rispettivamente. Nel quarto capitolo mostrerò che l’attenzione spaziale è coinvolta nella cognizione numerica, con cui intrattiene rapporti bidirezionali. Nello specifico mostrerò da un lato che la stimolazione optocinetica può modulare l’occorrenza di errori procedurali nel calcolo mentale, dall'altro che il calcolo stesso ha degli effetti sull'attenzione spaziale e in particolare sul comportamento oculomotorio. Nel quinto capitolo esaminerò gli effetti della stimolazione galvanica vestibolare, una tecnica particolarmente promettente per la riabilitazione dei disturbi attentivi lateralizzati, sulle rappresentazioni mentali dello spazio. Discuterò in modo critico un recente modello della negligenza spaziale unilaterale, suggerendo che stimolazioni e disturbi vestibolari possano sì avere ripercussioni sulle rappresentazioni metriche dello spazio, ma senza comportare necessariamente inattenzione per lo spazio stesso. Infine, nel sesto capitolo descriverò gli effetti di cattura dell’attenzione visuospaziale che stimoli distrattori intrinsecamente motivanti possono esercitare nell'adulto sano. Cercherò, in particolare, di predire l’entità di questa cattura attenzionale partendo da immagini di risonanza magnetica funzionale a riposo: riporterò dati preliminari focalizzati sull'importanza del circuito cingolo-opercolare, effettuando un parallelismo con popolazioni cliniche caratterizzate da comportamenti di dipendenza.
Buchteile zum Thema "Vestibular defect"
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Boyette, Jennings R. „Nasal Vestibular Lining Defect: Ipsilateral Septal Mucoperichondrial Hinge Flap“. In Matrix Head and Neck Reconstruction, 273–76. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-24981-5_58.
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Allum, J. H. J., M. Yamane und C. R. Pfaltz. „Vestibulo-Ocular Reflex Compensation in the Vertical and Horizontal Planes Following Unilateral Peripheral Vestibular Deficit in Man“. In Post-Lesion Neural Plasticity, 293–304. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73849-4_26.
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Allum, J. H. J., F. Honegger und E. A. Keshner. „Postural Responses of the Elderly: Comparisons with Vestibular-Deficit Subjects“. In Sensorimotor Impairment in the Elderly, 193–208. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1976-4_14.
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Hawkes, Christopher H., Kapil D. Sethi und Thomas R. Swift. „Cranial Nerves“. In Instant Neurological Diagnosis, 23–82. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199361953.003.0002.
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This chapter describes each cranial nerve and their associated Handles and Red Flags. In relation to the olfactory nerve various features accompanying anosmia are discussed. Visual acuity, field defects, congruity, transient painless monocular visual loss, disorders affecting the pupil and iris, fundoscopy, papilledema, and swollen optic disk are the main categories addressed concerning the optic nerve and visible parts of the eye. Disorders involving the oculomotor, trochlear, and abducens nerves include diplopia, supranuclear gaze paly, nystagmus, and proptosis. Diagnosis of conditions concerning the trigeminal and facial nerves are described. Those affecting the vestibulo-cochlear nerve include tinnitus, Fabry’s disease, deafness, and vestibular disorders. Palatal tremor/myoclonus and Trotter’s triad, disorders affecting the glossopharyngeal and vagus nerves, are included. Finally, Handles and Flags are provided for complaints involving the accessory nerve and hypoglossal nerves.
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Xie, Wen, und Maoli Duan. „Advances in Hearing Loss and Vestibular Disorders in Children“. In Advances in the Auditory and Vestibular Systems [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.106079.
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Pediatric hearing loss is a common sensory deficit, affecting nearly 9% of children worldwide. Compared with pediatric hearing loss, vestibular disorders are still not known among the child population. However, vestibular disorders are more and more generally known with time when the measurement of vestibular function is developing. Genetic causes and virus infection are the main causes of pediatric hearing loss, and vestibular migraine is the most common etiological disease of childhood vertigo. This narrative review of the literature discusses the brief etiopathology, the clinical manifestations of hearing loss and vestibular disorders in children, as well as available test protocols to diagnose childhood hearing loss and vestibular dysfunction.
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Rindler, Rima S., Christopher S. Graffeo, Colin L. W. Driscoll und Michael J. Link. „Small vestibular schwannoma with hearing deficit – upfront radiosurgery“. In Radiosurgery of the Skull Base: A Case-Based Approach, 169–74. Elsevier, 2024. http://dx.doi.org/10.1016/b978-0-323-87437-3.00049-3.
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Rindler, Rima S., Christopher S. Graffeo, Colin L. W. Driscoll und Michael J. Link. „Medium vestibular schwannoma with hearing deficit – upfront radiosurgery“. In Radiosurgery of the Skull Base: A Case-Based Approach, 157–60. Elsevier, 2024. http://dx.doi.org/10.1016/b978-0-323-87437-3.00046-8.
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Rindler, Rima S., Christopher S. Graffeo, Colin L. W. Driscoll und Michael J. Link. „Medium vestibular schwannoma without hearing deficit – upfront radiosurgery“. In Radiosurgery of the Skull Base: A Case-Based Approach, 151–56. Elsevier, 2024. http://dx.doi.org/10.1016/b978-0-323-87437-3.00045-6.
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Masetto, Sergio, Paolo Spaiardi und Stuart J. Johnson. „Signal Transmission by Auditory and Vestibular Hair Cells“. In Recent Advances in Audiological and Vestibular Research [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.107944.
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We interact with the world around us by sensing a vast array of inputs and translating them into signals that can be interpreted by the brain. We have evolved many sensory receptors, each uniquely specialised to detect diverse stimuli. The hair cells are sensory receptors, initially developed to provide a sense of body position and movement, but later adapted to sense minute pressure waves in the environment that are perceived as sounds. As such, hair cells bestow a sense of hearing and balance, which are major advantages for survival. Mammals have four different types of hair cell, two of which are dedicated to hearing, the inner and outer hair cells, and the other two to balance, the type-I and type-II hair cells. While all hair cells employ common mechanisms to detect and relay signals from sound or motion, they also have unique attributes that specialise them for a specific functional role. In this chapter we describe the process of signal transmission in mammalian auditory and vestibular hair cells. Since mammalian hair cells do not regenerate, their loss results in permanent auditory or vestibular deficit. Efforts to regenerate or repair malfunctioning hair cells have recently intensified, mainly through gene, stem-cell and molecular therapy.
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Mathiesen, Tiit, Petter Förander und David Pettersson. „Schwannomas“. In Oxford Textbook of Neurological Surgery, herausgegeben von Ramez W. Kirollos, Adel Helmy, Simon Thomson und Peter J. A. Hutchinson, 255–70. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780198746706.003.0022.
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Sporadic vestibular schwannoma (VS) is the commonest tumour of the cerebellopontine angle and comprise 6–8% of all intracranial tumours. The incidence varies between 12 and 20 cases per million inhabitants and years in different reports; a large minority of these tumours grow during follow-up. Treatment options include wait and scan, microsurgery, radiosurgery, and radiotherapy. Micro- and radiosurgery are well validated to offer long-term tumour control, but patients may suffer from hearing deficit and facial nerve paresis. Unexpectedly, long-term life quality is more affected by vertigo and headaches. Other cranial nerve schwannomas cause symptoms depending on the affected nerves and respond to the same therapies when treatment is indicated.
Konferenzberichte zum Thema "Vestibular defect"
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Kim, John, Molly Monsour, Davide Croci, Rachel Eakins und Siviero Agazzi. „Radiographic Factors Predicting Postoperative Facial Nerve Deficit in Vestibular Schwannomas“. In 32nd Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2023. http://dx.doi.org/10.1055/s-0043-1762142.
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Comeau, Perry, Alanna Wall, Kris Ellis und Arthur Gubbels. „Integrated Reality In-flight Simulation (IRIS): The Developmental Challenges“. In Vertical Flight Society 79th Annual Forum & Technology Display. The Vertical Flight Society, 2023. http://dx.doi.org/10.4050/f-0079-2023-18119.
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The National Research Council Canada (NRC) and Defence Research and Development Canada (DRDC) have developed modelling and simulation tools intended to de-risk, increase efficiency and standardize Ship Helicopter Operating Limitations (SHOL) testing through the use of modelling and simulation. The Integrated Reality In-Flight Simulation (IRIS) tool is a novel simulator platform where an evaluation pilot (EP) flies a variable stability aircraft while wearing a virtual reality (VR) headset with many elements of the shipboard environment carefully reproduced including the injection of real time turbulence models established from wind tunnel trials. The turbulence and other environmental effects on the aircraft motion are coupled directly into the aircraft in real time, thereby retaining accurate critical proprioceptive and vestibular cueing for the pilot. NRC has recently completed flight test evaluations of the prototype concept. Pilot comments from initial testing indicated that the system required little adaptation, presented no noticeable lag, no attributable propensity to cause motion sickness, and that the turbulence felt realistic.The testing indicated that typical VR deficiencies such as resolution and field of view are not as impactful during close-in shipboard operations, making this application very effective.
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Balan, Valeria, Magda Cernea und Madalina Georgescu. „EVALUATION OF THE BALANCE DEVELOPMENT OF THE DOWN'S SYNDROME CHILDREN WITH COMPUTER EQUIPMENT“. In eLSE 2016. Carol I National Defence University Publishing House, 2016. http://dx.doi.org/10.12753/2066-026x-16-223.
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The motor development of Down's syndrome children is slow. The different components of the motor capacity are developed gradually using practice. The education is more difficult, the progress is observed very difficulty and the decreasing of the level at which the Down's syndrome children reached is very quick. The deficit of the balance is associated with the Down syndrome too. The balance influences positively both the manner in which the children step and the possibility of changing the different directions during the movement without the children being injured. All these are possible if the balance is developed early in their life. Our research wished to evaluate the balance development at the tree Down's syndrome children using the computer equipment - SMART Balance Master. This stressed the progress obtained from the initial testing to the final testing. At the same time, it showed us the analyzer / analyzers where the development appeared after we had applied the stimulation programs (swimimng lessons) during a year. The children learnd to swim the fundamental techinque skills, freestyle and breaststroke during the stimulation programs (swimming lessons). Finally, we concluded: the family and social environment where the children grew up influnced all the activities that they practiced during the swimming lessons; the balance evaluation could achieve using the computer equipment. Which offered objective data about the level of the balance development of the children; SMART Balance Master stressed the improvement of the balance and indicated the level where the improvement appeared (proprioceptor level and vestibular level). The research was a part of a post-PhD thesis which was achieved and published under the aegis of the National University of Physical Education and Sports of Bucharest, as a partner of the programme co-funded by the European Social Fund within the Operational Sectorial Programme for Human Resources Development 2007-2013 through the project Pluri- and interdisciplinary in doctoral and post-doctoral programmes Project Code: POSDRU/159/1.5/S/141086, its main beneficiary being the Research Institute for Quality of Life, Romanian Academy.
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Balzana, Mariana Fortes, Giulia Bastos Buscema, Carolina Horstmann de Carvalho, Beatriz Ramiro Garcia Carneiro und Carolina Carvalho Mocarzel. „Gestante com complexo de limb body wall: relato de caso“. In 46º Congresso da SGORJ e Trocando Ideias XXV. Zeppelini Editorial e Comunicação, 2022. http://dx.doi.org/10.5327/jbg-0368-1416-2022132s1072.
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Introdução: O complexo de limb body wall (LBWC) é uma malformação rara, de etiologia desconhecida, com fenótipos variáveis e critério diagnóstico com duas das três manifestações anômalas entre as seguintes: exencefalia/encefalocele com fendas faciais, toraco e/ou abdominosquise e defeitos nos membros. Relato de caso: V.E.S.A.V., 19 anos, negra, solteira, estudante, natural do Rio de Janeiro, com múltiplas malformações congênitas caracterizando LBWC, incluindo mielocistocele, onfalocele rota, anomalia anorretal com fístula reto-vestibular, rim único à direita com ectasia de pelve renal e agenesia de membro inferior esquerdo. Paciente primigesta, com idade gestacional de 27 semanas e um dia. No período neonatal, foi realizada correção cirúrgica da mielocistocele e onfalocele, além de diagnóstico de bexiga neurogênica com necessidade de cateterismo intermitente. Em uso de anlodipino por hipertensão arterial crônica, oxibutinina e nitrofurantoína após infecções de trato urinário (ITU) de repetição. A paciente foi admitida em 23 de fevereiro de 2021 com relato de disúria, lombalgia e febre havia dois dias. Ao exame, pressão arterial de 160x100 mmHg, sem outras alterações de sinais vitais, útero desviado para a direita com fundo uterino de 24 cm, tônus uterino normal, sem metrossístoles e com batimento cardíaco fetal presente. Após a internação, houve otimização da medicação anti-hipertensiva, realização de hidratação e analgesia venosas, avaliação fetal sem alterações e início de antibioticoterapia venosa. A paciente relatou dor abdominal difusa desde o início do 2º trimestre, com piora progressiva conforme crescimento uterino, necessitando analgesia venosa. O ultrassom de vias urinárias revelou aumento importante de rim direito (27x14 cm), com aumento da ecogenicidade cortical e prejuízo da diferenciação, além de uretero-hidronefrose acentuada, com calibre de 4 cm e bexiga com parede espessada. Foi feito o diagnóstico de pré-eclâmpsia sobreposta após descontrole pressórico progressivo e alteração da proteinúria de 24 horas. Após a dificuldade no manejo da dor abdominal e lombar e a piora da função renal, foi prescrita corticoterapia para a maturação pulmonar fetal e foi feito o planejamento de parto com equipe multidisciplinar. A cesariana foi realizada em 1º de abril de 2021, sob raquianestesia, com 32 semanas e quatro dias, sem intercorrências; o RN nasceu sem malformações. Conclusão: A incidência de LBWC é de 0,32 em 100 mil nascimentos, já que a maioria dos fetos afetados sofre morte intrauterina. A paciente em questão possuía, ao nascimento, defeito da parede abdominal e em membro inferior, que são dois dos três critérios diagnósticos para LBWC. Apesar da gravidade, poucos estudos avaliaram a sobrevida de pacientes com LBWC após o nascimento, sendo difícil a comparação de casos. Não foram encontrados estudos ou relatos de gestantes que tenham nascido com essa síndrome, podendo este ser o primeiro caso descrito na literatura, sendo necessários mais estudos sobre esse complexo de malformações congênitas.